Page last updated: 2024-10-19

melatonin and Lesion of Sciatic Nerve

melatonin has been researched along with Lesion of Sciatic Nerve in 12 studies

Research Excerpts

ExcerptRelevanceReference
"Melatonin caused the increase in the pain threshold of the mechanical allodynia and the slight increase in the threshold of the thermal hyperalgesia."5.38Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012)
") melatonin on mechanical allodynia and thermal hyperalgesia in mice with partial tight ligation of the sciatic nerve, and how the nitric oxide (NO) precursor l-arginine and the opiate antagonist naloxone influence this effect."3.73Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system. ( Dokmeci, D; Guray, G; Ozyigit, F; Sapolyo, N; Tamer, M; Ulugol, A, 2006)
"Melatonin treatment was unable to influence on the recovery of the cut sciatic nerve in dark period."1.39Does circadian rhythm disruption induced by light-at-night has beneficial effect of melatonin on sciatic nerve injury? ( Aslan, M; Demir, N; Kaya, Y; Sarikcioglu, L; Yildirim, FB, 2013)
"Melatonin caused the increase in the pain threshold of the mechanical allodynia and the slight increase in the threshold of the thermal hyperalgesia."1.38Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012)
"Melatonin treatments increased the SFI values in the injured sciatic nerves."1.36Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury. ( Bilgin, MD; Yaraneri, H; Zencirci, SG, 2010)
"Melatonin (MT) plays an important role in the regulation of physiological and neuroendocrine functions, such as control of circadian rhythms and synchronization of seasonal reproductive rhythms in mammals."1.35[Effects of melatonin on nociception processes in experimentally model of neurophatic pain]. ( Ciesielczyk, K; Machowska, A; Nowak, Ł; Thor, PJ; Zurowski, D, 2008)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaya, Y2
Sarikcioglu, L2
Yildirim, FB1
Aslan, M1
Demir, N1
Savas, K1
Yaras, N1
Angelov, DN1
Ayaz, M1
Okudan, N1
Atik, B1
Erkutlu, I1
Tercan, M1
Buyukhatipoglu, H1
Bekerecioglu, M1
Pence, S1
Zurowski, D2
Nowak, Ł1
Ciesielczyk, K1
Machowska, A2
Thor, PJ2
Zencirci, SG1
Bilgin, MD1
Yaraneri, H1
Spaeth, CS1
Robison, T1
Fan, JD1
Bittner, GD1
Nowak, L1
Wordliczek, J1
Rogério, F2
Teixeira, SA1
de Rezende, AC1
de Sá, RC1
de Souza Queiroz, L1
De Nucci, G1
Muscará, MN1
Langone, F2
Ulugol, A1
Dokmeci, D1
Guray, G1
Sapolyo, N1
Ozyigit, F1
Tamer, M1
Jordão, H1
Vieira, AS1
Maria, CC1
Santos de Rezende, AC1
Pereira, GA1
Shokouhi, G1
Tubbs, RS1
Shoja, MM1
Hadidchi, S1
Ghorbanihaghjo, A1
Roshangar, L1
Farahani, RM1
Mesgari, M1
Oakes, WJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432]Phase 240 participants (Anticipated)Interventional2016-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

12 other studies available for melatonin and Lesion of Sciatic Nerve

ArticleYear
Does circadian rhythm disruption induced by light-at-night has beneficial effect of melatonin on sciatic nerve injury?
    Journal of chemical neuroanatomy, 2013, Volume: 53

    Topics: Animals; Antioxidants; Circadian Rhythm; Female; Melatonin; Nerve Regeneration; Rats; Rats, Wistar;

2013
Melatonin leads to axonal regeneration, reduction in oxidative stress, and improved functional recovery following sciatic nerve injury.
    Current neurovascular research, 2015, Volume: 12, Issue:1

    Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Electromyography; Female; Glutathione Perox

2015
Effects of melatonin supplementation on exercise-induced changes in conduction velocity distributions.
    Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:3

    Topics: Animals; Antioxidants; Melatonin; Neural Conduction; Physical Conditioning, Animal; Rats; Rats, Spra

2009
The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats.
    The Journal of surgical research, 2011, Volume: 166, Issue:2

    Topics: Action Potentials; Animals; Antioxidants; Collagen; Disease Models, Animal; Female; Melatonin; Motor

2011
[Effects of melatonin on nociception processes in experimentally model of neurophatic pain].
    Folia medica Cracoviensia, 2008, Volume: 49, Issue:3-4

    Topics: Animals; Disease Models, Animal; Male; Melatonin; Nociceptors; Pain Threshold; Rats; Rats, Wistar; R

2008
Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury.
    Journal of neuroscience methods, 2010, Aug-30, Volume: 191, Issue:2

    Topics: Animals; Disease Models, Animal; Male; Melatonin; Nerve Regeneration; Neuroprotective Agents; Periph

2010
Cellular mechanisms of plasmalemmal sealing and axonal repair by polyethylene glycol and methylene blue.
    Journal of neuroscience research, 2012, Volume: 90, Issue:5

    Topics: Animals; Antioxidants; Axons; Axotomy; Calcium; Cell Line, Tumor; Cell Membrane; Disease Models, Ani

2012
Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:6

    Topics: Analgesics; Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; GABA-A Receptor Ant

2012
Superoxide dismutase isoforms 1 and 2 in lumbar spinal cord of neonatal rats after sciatic nerve transection and melatonin treatment.
    Brain research. Developmental brain research, 2005, Feb-08, Volume: 154, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Blotting, Western; Cell Count; Immunohistochem

2005
Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system.
    Life sciences, 2006, Feb-28, Volume: 78, Issue:14

    Topics: Analgesics; Animals; Arginine; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricul

2006
Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment.
    Brain research, 2006, Sep-27, Volume: 1112, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Axotomy; bcl-2-Associated X Protein;

2006
Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2008, Volume: 24, Issue:1

    Topics: Analysis of Variance; Animals; Antioxidants; Dose-Response Relationship, Drug; Injections, Intraperi

2008