Page last updated: 2024-10-19

melatonin and Jet Lag

melatonin has been researched along with Jet Lag in 147 studies

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to compare the effectiveness and tolerability of a chronobiotic (melatonin) with a hypnotic (zolpidem) and the combination of both substances to alleviate jet lag symptoms associated with eastward travel."9.09Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. ( Höfer, I; Johnson, R; Schlagenhauf, P; Steffen, R; Suhner, A; Tschopp, A, 2001)
"Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle."7.96Design of multi-particulate "Dome matrix" with sustained-release melatonin and delayed-release caffeine for jet lag treatment. ( Benetti, C; Bose, A; Chong, PW; Colombo, P; Razali, S; Wong, TW, 2020)
"What is the effect of melatonin on jet lag syndrome? Jet lag desynchronizes the internal sleep-wakefulness cycle with the environmental light/dark cycle."7.72Melatonin and jet lag syndrome: experimental model and clinical implications. ( Oxenkrug, GF; Requintina, PJ, 2003)
"In order to assess the effect of melatonin on jet lag a field study was undertaken."7.70Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight. ( Hayshida, K; Itoh, H; Matsunaga, N; Obuchi, K; Ozone, M; Sano, H; Sasaki, M; Takahashi, T; Ushijima, S; Yamadera, W, 2000)
"Jet lag syndrome is an exogenous circadian rhythm sleep disorder, frequently reported in travelers who cross multiple time zones in a short period of time."6.52Is melatonin useful for jet lag? ( Farren, F; Rada, G; Tortorolo, F, 2015)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."6.46Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Jet lag is a disorder in which body rhythms are out of phase with the environment because of rapid travel across time zones."6.45Melatonin and its relevance to jet lag. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Trakht, I, 2009)
": To assess the effectiveness of oral melatonin taken in different dosage regimens for alleviating jet-lag after air travel across several time zones."6.41Melatonin for the prevention and treatment of jet lag. ( Herxheimer, A; Petrie, KJ, 2002)
"Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world."6.41Melatonin for preventing and treating jet lag. ( Herxheimer, A; Petrie, KJ, 2001)
"The symptoms of jet lag cause distress to an increasing number of travelers."6.41Jet lag: minimizing it's effects with critically timed bright light and melatonin administration. ( Parry, BL, 2002)
"The circadian rhythm disorder "jet lag" disturbs hippocampal neurogenesis and spatial cognition, which represent morphological and functional adult brain plasticity."5.46Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. ( Iggena, D; Steiner, B; Winter, Y, 2017)
"Athletes ingest melatonin in an attempt to improve sleep quality or alleviate symptoms of jet lag after transmeridian travel."5.09Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep? ( Atkinson, G; Buckley, P; Edwards, B; Reilly, T; Waterhouse, J, 2001)
"We investigated the management of travel fatigue and jet lag in athlete populations by evaluating studies that have applied non-pharmacological interventions (exercise, sleep, light and nutrition), and pharmacological interventions (melatonin, sedatives, stimulants, melatonin analogues, glucocorticoids and antihistamines) following long-haul transmeridian travel-based, or laboratory-based circadian system phase-shifts."5.05How to manage travel fatigue and jet lag in athletes? A systematic review of interventions. ( Bender, A; Claassen-Smithers, A; Cronje, T; Dunican, I; Fowler, P; Fullagar, H; Halson, S; Janse van Rensburg, DCC; Jansen van Rensburg, A; Lastella, M; Roach, GD; Sargent, C; Stevens, D; Vincent, G, 2020)
" We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag."4.88Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012)
"Bright light treatment is the most potent melatonin suppressor and circadian phase shifter and is a safe nonpharmacologic antidepressant for seasonal depression."4.82Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. ( Oren, DA; Postolache, TT, 2005)
" The main goal of this work was to prepare and characterize, elastic liposomes bearing melatonin, an anti-jet lag agent for its efficient transdermal delivery."3.74Elastic liposomes mediated transdermal delivery of an anti-jet lag agent: preparation, characterization and in vitro human skin transport study. ( Dubey, V; Jain, NK; Mishra, D; Nahar, M, 2008)
"What is the effect of melatonin on jet lag syndrome? Jet lag desynchronizes the internal sleep-wakefulness cycle with the environmental light/dark cycle."3.72Melatonin and jet lag syndrome: experimental model and clinical implications. ( Oxenkrug, GF; Requintina, PJ, 2003)
"Melatonin and light treatment are recommended for hastening adaptation to time zone change."2.76Phase advance with separate and combined melatonin and light treatment. ( Arendt, J; Gray, GW; Lieberman, HR; Love, RJ; Miller, JC; Paul, MA; Trouborst, M, 2011)
"Melatonin (or placebo) was administered at 1600 hours (phase advance) Wednesday, with DLMO assessment on Tuesday and Thursday and at 0600 hours (phase delay) Wednesday, with DLMO assessment Tuesday, Wednesday, and MelOff Thursday morning."2.75Melatonin treatment for eastward and westward travel preparation. ( Arendt, J; Gray, GW; Lieberman, HR; Love, RJ; Miller, JC; Paul, MA, 2010)
"Previous strategies to reduce jet lag have focused on shaping the perceived light-dark cycle after arrival, in order to facilitate a phase shift in the appropriate direction."2.71Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light. ( Burgess, HJ; Crowley, SJ; Eastman, CI; Fogg, LF; Gazda, CJ, 2003)
"Subjective ratings of jet lag, alertness, tenseness, and daytime fatigue were assessed using visual analog scales (VAS) and standardized questionnaires."2.70Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9h time shift: results of a placebo-controlled trial. ( Gerzer, R; Nickelsen, T; Samel, A; Smith, B; Vejvoda, M; Wenzel, J, 2002)
"Jet lag is a challenge for transmeridian travelers, while fatigue and alterations to gastrointestinal comfort are associated with many types of long-haul travel."2.61Nutrition for Travel: From Jet lag To Catering. ( Burke, LM; Halson, SL; Pearce, J, 2019)
"CME: Jet Lag Jetlag Abstract."2.58[CME: Jet Lag Jetlag]. ( Ensslin, A; Stutz, A, 2018)
"Jet lag is a syndrome caused by disruption of the 'body clock', and affects most air travellers crossing five or more time zones; it is worse on eastward than on westward flights."2.50Jet lag. ( Herxheimer, A, 2014)
"Jet lag has potentially serious deleterious effects on performance in athletes following transmeridian travel, where time zones are crossed eastwards or westwards; as such, travel causes specific effects related to desynchronization of the athlete's internal body clock or circadian clock."2.48Circadian disruption and remedial interventions: effects and interventions for jet lag for athletic peak performance. ( Cook, C; Drawer, S; Dudley, E; Forbes-Robertson, S; Kilduff, L; Vadgama, P, 2012)
"The classical symptoms of jet lag, such as tiredness during the day, mood swings and cognitive malfunction occur during this adjustment period."2.47[Rheumatism, jet lag and the body clock]. ( Pongratz, G; Straub, RH, 2011)
"Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle."2.46Circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D, 2010)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."2.46Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Circadian rhythm sleep disorders are categorized into six subtypes: Delayed sleep-phase disorder, advanced sleep-phase disorder, irregular sleep-wake rhythm, free-running disorder, jet-lag and shift work disorder."2.45[Circadian rhythm sleep disorders]. ( Bjorvatn, B; Pallesen, S, 2009)
"Jet lag is due to the misalignment of the internal circadian clock(s) with external time cues."2.45Managing jet lag: Some of the problems and possible new solutions. ( Arendt, J, 2009)
"Circadian rhythm sleep disorders are common in clinical practice."2.45A practical approach to circadian rhythm sleep disorders. ( Bjorvatn, B; Pallesen, S, 2009)
"Jet lag affects most air travellers crossing five or more time zones; it tends to be worse on eastward than on westward flights."2.44Jet lag. ( Herxheimer, A, 2008)
"Difficulties with jet lag because of sleep loss and decreased performance are emphasised."2.44Jet lag: trends and coping strategies. ( Atkinson, G; Edwards, B; Reilly, T; Waterhouse, J, 2007)
"There are consequences of jet lag that affect exercise performance and health."2.43Jet lag and air travel: implications for performance. ( Edwards, B; Reilly, T; Waterhouse, J, 2005)
"They demonstrate how jet lag could be prevented entirely if rhythms are shifted before the flight using their preflight plan and discuss the combination of interventions that they now recommend for night shift workers."2.43How to trick mother nature into letting you fly around or stay up all night. ( Eastman, CI; Revell, VL, 2005)
"Circadian rhythm sleep disorders, such as jet lag syndrome and shift work sleep disorder, are those specifically attributed to dysfunctions or insufficiencies in the circadian system."2.43The human circadian system in normal and disordered sleep. ( Richardson, GS, 2005)
"Melatonin has been successfully used to alleviate jet lag symptoms of travellers and there is also a smaller amount of evidence that the hormone helps shiftworkers adjust to nocturnal regimens."2.42The relevance of melatonin to sports medicine and science. ( Atkinson, G; Drust, B; Reilly, T; Waterhouse, J, 2003)
"Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle."2.41[Melatonin. II. Physiological and therapeutic effects]. ( Bruls, E; Crasson, M; Legros, JJ; Van Reeth, O, 2000)
"Melatonin profiles are a diagnostic tool to distinguish between several forms of depression, like major depression, winter depression (SAD), unipolar depression, delayed sleep phase syndrome (DSPS)."2.41Melatonin deficiencies in women. ( Herold, J; Rohr, UD, 2002)
"In elderly insomniacs, melatonin treatment decreased sleep latency and increased sleep efficiency."2.41Melatonin in sleep disorders and jet-lag. ( Brusco, LI; Cardinali, DP; Furio, AM; Pérez Lloret, S, 2002)
" Unequivocal estimations of the dosage of melatonin for best efficacy are not yet performed, although a range of different dosages have been tested."2.40Melatonin and jet-lag. ( Samel, A, 1999)
"Melatonin treatment has also been evaluated in the circadian sleep disorders: delayed sleep phase syndrome (DSPS) and non-24-hour sleep wake disorder."2.40Use of melatonin in the treatment of phase shift and sleep disorders. ( Arendt, J; Lockley, SW; Skene, DJ, 1999)
"Subjective jet lag was also measured at both time points."1.91To what extent is circadian phase predictive of subjective jet lag in long-haul cabin crew pre- and post-trip? ( Ellis, JG; Ogden, J; Ruscitto, C, 2023)
"CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment."1.62Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities. ( Abbott, SM; Burgess, HJ; Crowley, SJ; Duffy, JF; Emens, JS; Epstein, LJ; Gamble, KL; Hasler, BP; Klerman, EB; Kristo, DA; Malkani, RG; Rahman, SA; Thomas, SJ; Wyatt, JK; Zee, PC, 2021)
"Melatonin samples were taken at days 1, 7, 14 (baseline), day 23 (effect treatment), and day 30 (posttreatment)."1.43Short Blue Light Pulses (30 Min) in the Morning Support a Sleep-Advancing Protocol in a Home Setting. ( Beersma, DG; Geerdink, M; Gordijn, MC; Hommes, V; Walbeek, TJ, 2016)
"Jet lag and travel fatigue have been identified by athletes, athletic trainers, coaches, and physicians as important but challenging problems that could benefit from practical solutions."1.38Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams. ( Samuels, CH, 2012)
"This condition is termed jet lag that is characterized by sleep disturbances (insomnia, sleepiness), somatic symptoms, and decrease in mental and physical outputs."1.37[Clinical picture and treatment of jet lag]. ( Igaz, P; Tulassay, Z, 2011)
"After the 12-h experimental jet lag through extending the light period, BEC feeding markedly facilitated the re-entrainment of all examined clock genes (Bmal1, Cry1, Per1, and Per2) in the pineal gland."1.37Effect of BRAND's essence of chicken on the resetting process of circadian clocks in rats subjected to experimental jet lag. ( Abe, K; Fu, Z; Hong, LK; Ni, Y; Watanabe, H; Wu, T, 2011)
"Jet lag is often cited as a cause of poor sporting performance."1.34Beating jet lag. ( Fuard, MH; Milne, CJ, 2007)

Research

Studies (147)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (4.76)18.2507
2000's78 (53.06)29.6817
2010's53 (36.05)24.3611
2020's9 (6.12)2.80

Authors

AuthorsStudies
Ruscitto, C1
Ogden, J1
Ellis, JG1
Garbellotto, L1
Petit, E1
Brunet, E1
Guirronnet, S1
Clolus, Y1
Gillet, V1
Bourdin, H1
Mougin, F1
Youngstedt, SD3
Elliott, J3
Patel, S3
Zi-Ching Mak, N3
Raiewski, E3
Malek, E3
Strong, M3
Mun, CJ3
Peters, T3
Madlol, R3
Tasevska, N3
Rasoul, M3
Nguyen, C3
Vargas Negrete, KM3
Adaralegbe, AO3
Sudalaimuthu, S3
Granholm, D3
Finch, A3
Eksambe, A3
Malready, A3
Parthasarathy, S3
Vetter, C1
Phillips, AJK1
Silva, A1
Lockley, SW2
Glickman, G1
Janse van Rensburg, DCC1
Jansen van Rensburg, A1
Fowler, P1
Fullagar, H1
Stevens, D1
Halson, S1
Bender, A1
Vincent, G1
Claassen-Smithers, A1
Dunican, I1
Roach, GD1
Sargent, C1
Lastella, M1
Cronje, T1
Razali, S1
Bose, A1
Chong, PW1
Benetti, C1
Colombo, P1
Wong, TW1
Duffy, JF2
Abbott, SM1
Burgess, HJ4
Crowley, SJ3
Emens, JS1
Epstein, LJ1
Gamble, KL1
Hasler, BP1
Kristo, DA1
Malkani, RG1
Rahman, SA1
Thomas, SJ1
Wyatt, JK1
Zee, PC4
Klerman, EB1
Vieira, RPO1
Nehme, PXSA1
Marqueze, EC1
Amaral, FG1
Cipolla-Neto, J1
Moreno, CRC1
Joly, E1
Woelders, T1
Beersma, DGM1
Gordijn, MCM1
Hut, RA1
Wams, EJ1
Pfeffer, M2
Korf, HW2
Wicht, H1
Groß, JV1
Fritschi, L1
Kim, JH1
Ni, Y2
Ma, L1
Wu, T2
Lim, AL1
Zhang, W1
Yang, L1
Nakao, Y1
Fu, Z2
Stutz, A1
Ensslin, A1
Arendt, J8
Zerbini, G1
Kantermann, T1
Merrow, M1
Halson, SL1
Burke, LM2
Pearce, J1
Bin, YS1
Postnova, S1
Cistulli, PA1
Golombek, DA2
Casiraghi, LP1
Agostino, PV1
Paladino, N1
Duhart, JM1
Plano, SA1
Chiesa, JJ1
Kommedal, S1
Csernus, V1
Nagy, AD1
Czeisler, CA1
Anisimov, VN2
Vinogradova, IA2
Bukalev, AV2
Borisenkov, MF1
Popovich, IG2
Zabezhinskiĭ, MA2
Panchenko, AV2
Tyndyk, ML2
Iurova, MH1
Kovacic, P1
Somanathan, R1
Iwamoto, A1
Kawai, M1
Furuse, M1
Yasuo, S1
Rawashdeh, O1
Dubocovich, ML1
Herxheimer, A8
Iurova, MN1
Atkinson, G5
Batterham, AM1
Dowdall, N1
Thompson, A1
van Drongelen, A1
Cuesta, M1
Cermakian, N1
Boivin, DB1
Tortorolo, F1
Farren, F1
Rada, G1
Wieczorek, J1
Blazejczyk, K1
Morita, T1
Noyek, S1
Yaremchuk, K1
Rotenberg, B1
Geerdink, M1
Walbeek, TJ1
Beersma, DG1
Hommes, V1
Gordijn, MC1
Iggena, D1
Winter, Y1
Steiner, B1
Zulley, J1
Hajak, G1
Dubey, V1
Mishra, D1
Nahar, M1
Jain, NK1
Bjorvatn, B2
Pallesen, S2
Brown, GM2
Pandi-Perumal, SR3
Trakht, I1
Cardinali, DP7
Coste, O4
Lagarde, D4
Reilly, T6
Waterhouse, J7
Edwards, B4
Sack, RL2
Paul, MA3
Miller, JC4
Love, RJ3
Lieberman, H1
Blazeski, S1
Van Beers, P2
Touitou, Y1
Gray, GW2
Lieberman, HR2
Jackson, G1
Michalik, A1
Bobiński, R1
Martinez, D1
Lenz, Mdo C1
Wang-Weigand, S1
Wright, KP1
Peng, X1
Roth, T1
Rios, ER1
Venâncio, ET1
Rocha, NF1
Woods, DJ1
Vasconcelos, S1
Macedo, D1
Sousa, FC1
Fonteles, MM1
Srinivasan, V2
Singh, J1
Spence, DW1
Watanabe, H1
Hong, LK1
Abe, K1
Barlach, M1
Goto, K2
Racinais, S1
Trouborst, M1
Reid, KJ2
McGee-Koch, LL1
Pongratz, G1
Straub, RH1
Lundy, B1
Jackson, K1
Senchina, DS1
Stear, SJ1
Castell, LM1
Kolla, BP1
Auger, RR1
Perrier, E1
Manen, O1
Igaz, P1
Tulassay, Z1
Forbes-Robertson, S1
Dudley, E1
Vadgama, P1
Cook, C1
Drawer, S1
Kilduff, L1
Samuels, CH1
Rauch, A1
von Gall, C1
Carter, MD1
Juurlink, DN1
Eastman, CI7
Molina, TA1
Dziepak, ME1
Smith, MR2
Adan, A1
Archer, SN1
Hidalgo, MP1
Di Milia, L1
Natale, V1
Randler, C1
Robb-Nicholson, C1
Leatherwood, WE1
Dragoo, JL1
Lemmer, B1
Kern, RI1
Nold, G1
Lohrer, H1
Boulos, Z1
Macchi, MM1
Stürchler, MP1
Stewart, KT1
Brainard, GC1
Suhner, A2
Wallace, G1
Steffen, R2
Nickelsen, T1
Samel, A2
Vejvoda, M1
Wenzel, J1
Smith, B1
Gerzer, R1
Parry, BL1
Smucny, J1
Oxenkrug, GF1
Requintina, PJ1
Okawa, M1
Uchiyama, M1
Miike, T1
Gazda, CJ3
Fogg, LF3
Drust, B1
Beaumont, M2
Batéjat, D1
Piérard, C2
Denis, JB1
Doireau, P1
Chauffard, F3
French, J3
Nir, I1
Chang, AM1
Rüdiger, HW1
Postolache, TT2
Hung, TM1
Rosenthal, RN1
Soriano, JJ1
Montes, F1
Stiller, JW1
Oren, DA1
Revell, VL2
Leproult, R1
Van Onderbergen, A1
L'hermite-Balériaux, M1
Van Cauter, E1
Copinschi, G1
Cajochen, Ch1
Richardson, GS1
Garau, C1
Aparicio, S1
Rial, RV1
Nicolau, MC1
Esteban, S1
Furio, AM2
Reyes, MP1
Brusco, LI2
Johnsson, A1
Moan, J1
Smits, M1
Spence, W1
Lowe, AD1
Kayumov, L1
Nicholson, AN1
Trufakin, VA1
Shurlygina, AV1
Milne, CJ1
Fuard, MH1
Altun, A1
Ugur-Altun, B1
Vollenweider, S1
Wirz-Justice, A1
Flammer, J1
Orgül, S1
Kräuchi, K1
Pepping, J1
Katz, G2
Durst, R2
Barel, YC1
Knobler, HY2
Skene, DJ1
Edwards, BJ1
Godfrey, R1
Budgett, R1
Bruls, E1
Crasson, M1
Van Reeth, O1
Legros, JJ1
Martin, SK1
Hebert, M1
Takahashi, T3
Sasaki, M3
Itoh, H3
Ozone, M3
Yamadera, W3
Hayshida, K1
Ushijima, S1
Matsunaga, N3
Obuchi, K3
Sano, H3
Barattini, P1
Dolci, C1
Montaruli, A1
Roveda, E1
Carandente, F1
Petrie, KJ2
Chappuis, B1
Billaud, PF1
Ramont, L1
Buckley, P1
Christiansen, AL1
Madsbad, S1
Hayashida, KI1
Zisapel, N1
Schlagenhauf, P1
Höfer, I1
Johnson, R1
Tschopp, A1
Tresguerres, JA1
Ariznavarreta, C1
Granados, B1
Martín, M1
Villanúa, MA1
Enslen, M1
Tan, DX1
Reiter, RJ1
Fontan, A1
Sharkey, KM1
Laitinen, JT1
Porkka-Heiskanen, T1
Bortman, GP1
Liotta, G1
Pérez Lloret, S2
Albornoz, LE1
Cutrera, RA1
Batista, J1
Ortega Gallo, P1
Rohr, UD1
Herold, J1
Hayashida, K1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms[NCT03758768]34 participants (Actual)Interventional2018-09-25Completed
Does CBT Improve the Effect of Light Therapy in Delayed Sleep Phase Syndrome Compared to Only Light Therapy - Short and Long Term Follow up[NCT01419938]57 participants (Actual)Interventional2011-08-31Completed
A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Ability of Ramelteon 1 mg, 4 mg, and 8 mg to Alleviate the Insomnia Symptoms Associated With Eastward Bound Jet Lag Across 5 Time Zones in Healthy Adult Volunteers[NCT00492011]Phase 4110 participants (Actual)Interventional2007-02-28Completed
Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398]71 participants (Actual)Interventional2018-01-23Completed
Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder[NCT00502320]Phase 450 participants (Actual)Interventional2006-09-30Completed
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]Phase 325 participants (Actual)Interventional2016-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Structured Interview Guide for the Hamilton Depression Rating - Seasonal Affective Disorder (SIGH-SAD)

Clinician-rated measure of mood; evaluates classical 21 Hamilton Depression items, and 8-item subscale measuring atypical depression symptoms which commonly occur during SAD episodes. Score ranges from 0-89, higher scores indicate higher levels of depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo19.9915.9719.4720.6523.68
Ramelteon22.6816.1614.8111.699.15

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Zung Depression Scale (ZDS)

Self-rated scale to measure severity of depressive symptoms. Score ranges from 25-100, higher scores reflect more depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo58.6356.4058.5958.6261.65
Ramelteon63.0654.3553.5149.2646.14

Sleep Satisfaction at Baseline and Measured Monthly, as Measured by the Pittsburgh Sleep Quality Index (PSQI)

Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Score ranges from 0-21, higher scores represent more significant sleep disturbance. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo11.458.678.629.889.61
Ramelteon11.569.527.578.077.05

Reviews

69 reviews available for melatonin and Jet Lag

ArticleYear
Melatonin for jet lag.
    Drug and therapeutics bulletin, 2020, Volume: 58, Issue:2

    Topics: Humans; Jet Lag Syndrome; Melatonin; Meta-Analysis as Topic

2020
How to manage travel fatigue and jet lag in athletes? A systematic review of interventions.
    British journal of sports medicine, 2020, Volume: 54, Issue:16

    Topics: Benzodiazepines; Circadian Rhythm; Exercise Therapy; Glucocorticoids; Histamine Antagonists; Humans;

2020
Synchronizing effects of melatonin on diurnal and circadian rhythms.
    General and comparative endocrinology, 2018, 03-01, Volume: 258

    Topics: Animals; Circadian Clocks; Circadian Rhythm; Humans; Hypothalamus; Jet Lag Syndrome; Locomotion; Mal

2018
Circadian Rhythm Sleep-Wake Disorders in Older Adults.
    Sleep medicine clinics, 2018, Volume: 13, Issue:1

    Topics: Aged; Central Nervous System Depressants; Circadian Clocks; Circadian Rhythm; Humans; Jet Lag Syndro

2018
[CME: Jet Lag Jetlag].
    Praxis, 2018, Volume: 107, Issue:15

    Topics: Circadian Rhythm; Diagnosis, Differential; Dyssomnias; Humans; Individuality; Jet Lag Syndrome; Male

2018
Approaches to the Pharmacological Management of Jet Lag.
    Drugs, 2018, Volume: 78, Issue:14

    Topics: Animals; Circadian Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Sleep; Trav

2018
Nutrition for Travel: From Jet lag To Catering.
    International journal of sport nutrition and exercise metabolism, 2019, Mar-01, Volume: 29, Issue:2

    Topics: Athletes; Caffeine; Humans; Jet Lag Syndrome; Light; Meals; Melatonin; Sports Nutritional Physiologi

2019
What works for jetlag? A systematic review of non-pharmacological interventions.
    Sleep medicine reviews, 2019, Volume: 43

    Topics: Circadian Rhythm; Fatigue; Humans; Jet Lag Syndrome; Melatonin; Photoperiod; Sleep; Travel

2019
The times they're a-changing: effects of circadian desynchronization on physiology and disease.
    Journal of physiology, Paris, 2013, Volume: 107, Issue:4

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Phototherap

2013
[Light desynchronization and the risk of cancer in humans: the state of the problem].
    Voprosy onkologii, 2013, Volume: 59, Issue:3

    Topics: Circadian Rhythm; DNA Damage; Humans; Jet Lag Syndrome; Light; Melatonin; Neoplasms; Photoperiod; Wo

2013
Cell signaling, receptors, electrical effects and therapy in circadian rhythm.
    Journal of receptor and signal transduction research, 2013, Volume: 33, Issue:5

    Topics: Animals; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Electroconvulsive Therapy; Humans; Jet

2013
Jet lag.
    BMJ clinical evidence, 2014, Apr-29, Volume: 2014

    Topics: Antioxidants; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Life Style; Melatonin; Safety

2014
[Light-induced disruption of the circadian clock and risk of malignant tumors in laboratory animals: state of the problem].
    Voprosy onkologii, 2014, Volume: 60, Issue:2

    Topics: Animals; Animals, Laboratory; Antioxidants; Biological Clocks; Carcinogens; Central Nervous System D

2014
From animal cage to aircraft cabin: an overview of evidence translation in jet lag research.
    European journal of applied physiology, 2014, Volume: 114, Issue:12

    Topics: Animals; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Translational Research, Biomedical

2014
Is melatonin useful for jet lag?
    Medwave, 2015, Dec-21, Volume: 15 Suppl 3

    Topics: Antioxidants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Randomized Controlled Trials as

2015
Does melatonin have a meaningful role as a sleep aid for jet lag recovery?
    The Laryngoscope, 2016, Volume: 126, Issue:8

    Topics: Central Nervous System Depressants; Humans; Jet Lag Syndrome; Melatonin; Sleep

2016
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
Managing jet lag: Some of the problems and possible new solutions.
    Sleep medicine reviews, 2009, Volume: 13, Issue:4

    Topics: Adaptation, Physiological; Circadian Rhythm; Combined Modality Therapy; Genetic Predisposition to Di

2009
Melatonin and its relevance to jet lag.
    Travel medicine and infectious disease, 2009, Volume: 7, Issue:2

    Topics: Aircraft; Chronotherapy; Circadian Rhythm; Exercise; Humans; Hypnotics and Sedatives; Jet Lag Syndro

2009
Clinical management of jet lag: what can be proposed when performance is critical?
    Travel medicine and infectious disease, 2009, Volume: 7, Issue:2

    Topics: Aircraft; Caffeine; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian Rhythm; Hu

2009
Some chronobiological and physiological problems associated with long-distance journeys.
    Travel medicine and infectious disease, 2009, Volume: 7, Issue:2

    Topics: Aircraft; Biological Clocks; Body Temperature; Central Nervous System Depressants; Eating; Environme

2009
The pathophysiology of jet lag.
    Travel medicine and infectious disease, 2009, Volume: 7, Issue:2

    Topics: Aircraft; Central Nervous System Depressants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin;

2009
Jet lag.
    BMJ clinical evidence, 2008, Dec-04, Volume: 2008

    Topics: Air Travel; Azabicyclo Compounds; Caffeine; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melat

2008
[Circadian rhythm sleep disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009, Sep-24, Volume: 129, Issue:18

    Topics: Central Nervous System Depressants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Dis

2009
["Jet-lag"--pathophysiology and methods of prevention and treatment].
    Przeglad epidemiologiczny, 2009, Volume: 63, Issue:4

    Topics: Central Nervous System Stimulants; Chronobiology Phenomena; Circadian Rhythm; Humans; Jet Lag Syndro

2009
Clinical practice. Jet lag.
    The New England journal of medicine, 2010, Feb-04, Volume: 362, Issue:5

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged; Phototherapy; Practice Gui

2010
Circadian rhythm sleep disorders.
    The Indian journal of medical research, 2010, Volume: 131

    Topics: Biological Clocks; Circadian Rhythm; Guidelines as Topic; Humans; Jet Lag Syndrome; Melatonin; Polys

2010
Melatonin: pharmacological aspects and clinical trends.
    The International journal of neuroscience, 2010, Volume: 120, Issue:9

    Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Free Radical Scavengers; Humans; Indenes;

2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.
    Advances in therapy, 2010, Volume: 27, Issue:11

    Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Hum

2010
Different effects of heat exposure upon exercise performance in the morning and afternoon.
    Scandinavian journal of medicine & science in sports, 2010, Volume: 20 Suppl 3

    Topics: Adaptation, Physiological; Body Temperature; Body Temperature Regulation; Circadian Rhythm; Environm

2010
Cognition in circadian rhythm sleep disorders.
    Progress in brain research, 2011, Volume: 190

    Topics: Biological Clocks; Circadian Rhythm; Cognition; Humans; Jet Lag Syndrome; Light; Melatonin; Psychomo

2011
[Rheumatism, jet lag and the body clock].
    Zeitschrift fur Rheumatologie, 2011, Volume: 70, Issue:4

    Topics: Adaptation, Physiological; Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Bio

2011
A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance - part 25.
    British journal of sports medicine, 2011, Volume: 45, Issue:13

    Topics: Anti-Inflammatory Agents; Athletic Performance; Dietary Supplements; Dimethyl Sulfoxide; Humans; Jet

2011
Jet lag and shift work sleep disorders: how to help reset the internal clock.
    Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:10

    Topics: Actigraphy; Age Factors; Benzodiazepines; Caffeine; Central Nervous System Depressants; Central Nerv

2011
[Jet lag disorders].
    La Revue de medecine interne, 2011, Volume: 32 Suppl 2

    Topics: Aircraft; Central Nervous System Stimulants; Chronobiology Phenomena; Humans; Hypnotics and Sedative

2011
Circadian disruption and remedial interventions: effects and interventions for jet lag for athletic peak performance.
    Sports medicine (Auckland, N.Z.), 2012, Mar-01, Volume: 42, Issue:3

    Topics: Adaptation, Physiological; Adolescent; Adult; Animals; Athletic Performance; Circadian Rhythm; Diet;

2012
Circadian typology: a comprehensive review.
    Chronobiology international, 2012, Volume: 29, Issue:9

    Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di

2012
Effect of airline travel on performance: a review of the literature.
    British journal of sports medicine, 2013, Volume: 47, Issue:9

    Topics: Air Travel; Altitude; Athletic Performance; Benzodiazepines; Central Nervous System Depressants; Cir

2013
Jet lag: minimizing it's effects with critically timed bright light and melatonin administration.
    Journal of molecular microbiology and biotechnology, 2002, Volume: 4, Issue:5

    Topics: Acclimatization; Aircraft; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Phototherap

2002
The relevance of melatonin to sports medicine and science.
    Sports medicine (Auckland, N.Z.), 2003, Volume: 33, Issue:11

    Topics: Aging; Body Temperature; Circadian Rhythm; Exercise; Humans; Hypothermia; Jet Lag Syndrome; Melatoni

2003
Melatonin for the treatment of disorders in circadian rhythm and sleep: could it form a basis for medication?
    Receptors & channels, 2003, Volume: 9, Issue:6

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Deprivation; Sleep Disorders, Ci

2003
Circadian rhythm sleep disorders.
    The Medical clinics of North America, 2004, Volume: 88, Issue:3

    Topics: Body Temperature; Chronobiology Disorders; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Photo

2004
Jet lag.
    Clinical evidence, 2004, Issue:11

    Topics: Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin

2004
Jet lag.
    Clinical evidence, 2004, Issue:12

    Topics: Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin

2004
Jet lag and air travel: implications for performance.
    Clinics in sports medicine, 2005, Volume: 24, Issue:2

    Topics: Aircraft; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Female; Humans; Hypnotics a

2005
Sports chronobiology consultation: from the lab to the arena.
    Clinics in sports medicine, 2005, Volume: 24, Issue:2

    Topics: Altitude; Biological Clocks; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian R

2005
Circadian phase shifting, alerting, and antidepressant effects of bright light treatment.
    Clinics in sports medicine, 2005, Volume: 24, Issue:2

    Topics: Adaptation, Physiological; Adult; Bipolar Disorder; Circadian Rhythm; Depression; Eye Diseases; Fema

2005
How to trick mother nature into letting you fly around or stay up all night.
    Journal of biological rhythms, 2005, Volume: 20, Issue:4

    Topics: Animals; Aviation; Circadian Rhythm; Darkness; Humans; Jet Lag Syndrome; Light; Melatonin; Work Sche

2005
Jet lag.
    Clinical evidence, 2005, Issue:13

    Topics: Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin

2005
[Melatonin].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8

    Topics: Aging; Biomarkers; Breast Neoplasms; Chromatography, High Pressure Liquid; Circadian Rhythm; Depress

2005
[Sleep disruption in shift work and jet lag: the role of the circadian timing system].
    Praxis, 2005, Sep-21, Volume: 94, Issue:38

    Topics: Adult; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hypnotic

2005
The human circadian system in normal and disordered sleep.
    The Journal of clinical psychiatry, 2005, Volume: 66 Suppl 9

    Topics: Biological Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Receptors, Melatoni

2005
The use of chronobiotics in the resynchronization of the sleep-wake cycle.
    Cancer causes & control : CCC, 2006, Volume: 17, Issue:4

    Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Light; Melatonin; Sleep; Sleep Disorders, Circadia

2006
[Rhythms, depressions and light].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2006, Apr-06, Volume: 126, Issue:8

    Topics: Animals; Biological Clocks; Bipolar Disorder; Brain; Circadian Rhythm; Humans; Jet Lag Syndrome; Lig

2006
Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Jan-30, Volume: 31, Issue:1

    Topics: Animals; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Periodicity; Sleep; Suprachia

2007
[The problems of the central regulation of immune system biorhythms: the role of exogenous and endogenous melatonin].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2006, Issue:9-10

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Asthma; Circ

2006
Melatonin: therapeutic and clinical utilization.
    International journal of clinical practice, 2007, Volume: 61, Issue:5

    Topics: Cardiovascular Diseases; Circadian Rhythm; Humans; Immune System; Immune System Diseases; Jet Lag Sy

2007
Jet lag: trends and coping strategies.
    Lancet (London, England), 2007, Mar-31, Volume: 369, Issue:9567

    Topics: Adaptation, Psychological; Humans; Jet Lag Syndrome; Melatonin; Sleep Disorders, Circadian Rhythm; S

2007
Melatonin and jet-lag.
    European journal of medical research, 1999, Sep-09, Volume: 4, Issue:9

    Topics: Aircraft; Humans; Jet Lag Syndrome; Melatonin; Occupational Diseases

1999
Jet-lag and shift work: (2). Therapeutic use of melatonin.
    Journal of the Royal Society of Medicine, 1999, Volume: 92, Issue:8

    Topics: Antioxidants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Work Schedule Tolerance

1999
Use of melatonin in the treatment of phase shift and sleep disorders.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Blindness; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Wake Disorders; Work Schedul

1999
[Melatonin. II. Physiological and therapeutic effects].
    Revue medicale de Liege, 2000, Volume: 55, Issue:9

    Topics: Anticarcinogenic Agents; Antioxidants; Chronobiology Phenomena; Circadian Rhythm; Humans; Jet Lag Sy

2000
Melatonin for preventing and treating jet lag.
    The Cochrane database of systematic reviews, 2001, Issue:1

    Topics: Antioxidants; Humans; Jet Lag Syndrome; Melatonin; Randomized Controlled Trials as Topic

2001
[Jet leg].
    Ugeskrift for laeger, 2001, Jan-08, Volume: 163, Issue:2

    Topics: Animals; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Practice Guidelines as

2001
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.
    CNS drugs, 2001, Volume: 15, Issue:4

    Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Sleep; Sleep Disorders, C

2001
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses].
    Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:5

    Topics: Animals; Biological Clocks; Blindness; Chronobiology Disorders; Humans; Jet Lag Syndrome; Light; Mel

1999
Melatonin deficiencies in women.
    Maturitas, 2002, Apr-15, Volume: 41 Suppl 1

    Topics: Breast Neoplasms; Circadian Rhythm; Depression; Female; Humans; Jet Lag Syndrome; Melatonin; Menopau

2002
Melatonin in sleep disorders and jet-lag.
    Neuro endocrinology letters, 2002, Volume: 23 Suppl 1

    Topics: Aged; Animals; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Initiation and Maintenance Disorder

2002
Melatonin for the prevention and treatment of jet lag.
    The Cochrane database of systematic reviews, 2002, Issue:2

    Topics: Antioxidants; Humans; Jet Lag Syndrome; Melatonin; Randomized Controlled Trials as Topic

2002

Trials

17 trials available for melatonin and Jet Lag

ArticleYear
Circadian acclimatization of performance, sleep, and 6-sulfatoxymelatonin using multiple phase shifting stimuli.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Acclimatization; Adult; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleepiness

2022
Circadian acclimatization of performance, sleep, and 6-sulfatoxymelatonin using multiple phase shifting stimuli.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Acclimatization; Adult; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleepiness

2022
Circadian acclimatization of performance, sleep, and 6-sulfatoxymelatonin using multiple phase shifting stimuli.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Acclimatization; Adult; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleepiness

2022
Circadian acclimatization of performance, sleep, and 6-sulfatoxymelatonin using multiple phase shifting stimuli.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Acclimatization; Adult; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleepiness

2022
Glucocorticoids entrain molecular clock components in human peripheral cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:4

    Topics: Adult; ARNTL Transcription Factors; Circadian Rhythm; Double-Blind Method; Drug Administration Sched

2015
Melatonin treatment for eastward and westward travel preparation.
    Psychopharmacology, 2010, Volume: 208, Issue:3

    Topics: Adult; Biological Clocks; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Drug A

2010
Effects of ramelteon on insomnia symptoms induced by rapid, eastward travel.
    Sleep medicine, 2010, Volume: 11, Issue:6

    Topics: Actigraphy; Adult; Case-Control Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fema

2010
Phase advance with separate and combined melatonin and light treatment.
    Psychopharmacology, 2011, Volume: 214, Issue:2

    Topics: Actigraphy; Adaptation, Physiological; Administration, Oral; Adult; Analysis of Variance; Biological

2011
Light visor treatment for jet lag after westward travel across six time zones.
    Aviation, space, and environmental medicine, 2002, Volume: 73, Issue:10

    Topics: Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Phototherapy; Psychomoto

2002
Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9h time shift: results of a placebo-controlled trial.
    Chronobiology international, 2002, Volume: 19, Issue:5

    Topics: Adaptation, Physiological; Adult; Body Temperature; Circadian Rhythm; Cross-Over Studies; Double-Bli

2002
Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light.
    Journal of biological rhythms, 2003, Volume: 18, Issue:4

    Topics: Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Lighting; Male; Melatonin; Phototherapy;

2003
Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:1

    Topics: Adult; Anticonvulsants; Body Temperature; Caffeine; Central Nervous System Stimulants; Female; Human

2004
Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.
    Clinical endocrinology, 2005, Volume: 63, Issue:3

    Topics: Acetamides; Aged; Body Temperature; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Growt

2005
Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:1

    Topics: Adult; Antioxidants; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Light; Male; Melatonin; Mid

2006
Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones.
    Ergonomics, 2000, Volume: 43, Issue:10

    Topics: Adult; Antioxidants; Body Temperature; Circadian Rhythm; Female; Hand Strength; Humans; Jet Lag Synd

2000
Evaluation of pharmacological aids on physical performance after a transmeridian flight.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:4

    Topics: Adult; Analysis of Variance; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rh

2001
Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep?
    International journal of sports medicine, 2001, Volume: 22, Issue:3

    Topics: Adult; Analysis of Variance; Body Temperature; Chronotherapy; Double-Blind Method; Drug Administrati

2001
Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag.
    Aviation, space, and environmental medicine, 2001, Volume: 72, Issue:7

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Circadian Rhythm; Double-Blind Method; Female; Hormon

2001
Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin.
    European journal of applied physiology, 2001, Volume: 85, Issue:1-2

    Topics: Adjuvants, Immunologic; Adult; Caffeine; Central Nervous System Stimulants; Delayed-Action Preparati

2001
Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:2

    Topics: Adjuvants, Immunologic; Adult; Affect; Body Temperature; Circadian Rhythm; Female; Humans; Jet Lag S

2002

Other Studies

61 other studies available for melatonin and Jet Lag

ArticleYear
To what extent is circadian phase predictive of subjective jet lag in long-haul cabin crew pre- and post-trip?
    Applied ergonomics, 2023, Volume: 106

    Topics: Actigraphy; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep

2023
Gradual Advance of Sleep-Wake Schedules Before an Eastward Flight and Phase Adjustment After Flight in Elite Cross-Country Mountain Bikers: Effects on Sleep and Performance.
    Journal of strength and conditioning research, 2023, Apr-01, Volume: 37, Issue:4

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Polysomnography; Sleep

2023
Light Me up? Why, When, and How Much Light We Need.
    Journal of biological rhythms, 2019, Volume: 34, Issue:6

    Topics: Animals; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Photoperiod; Sleep

2019
Design of multi-particulate "Dome matrix" with sustained-release melatonin and delayed-release caffeine for jet lag treatment.
    International journal of pharmaceutics, 2020, Sep-25, Volume: 587

    Topics: Animals; Caffeine; Delayed-Action Preparations; Jet Lag Syndrome; Melatonin; Polymers; Rats; Solubil

2020
Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
    Sleep, 2021, 05-14, Volume: 44, Issue:5

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sle

2021
High social jetlag is correlated with nocturnal inhibition of melatonin production among night workers.
    Chronobiology international, 2021, Volume: 38, Issue:8

    Topics: Brazil; Circadian Rhythm; Female; Humans; Hydrocortisone; Jet Lag Syndrome; Melatonin; Pregnancy; Sl

2021
Baseball and jet lag: Correlation does not imply causation.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-18, Volume: 114, Issue:16

    Topics: Baseball; Circadian Rhythm; Jet Lag Syndrome; Melatonin; Travel

2017
Daily Light Exposure Patterns Reveal Phase and Period of the Human Circadian Clock.
    Journal of biological rhythms, 2017, Volume: 32, Issue:3

    Topics: Adult; Body Temperature; Circadian Clocks; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Light

2017
Complementing the Social Jet Lag by considering pristine internal time.
    Chronobiology international, 2017, Volume: 34, Issue:9

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep

2017
The involvement of sympathetic nervous system in essence of chicken-facilitated physiological adaption and circadian resetting.
    Life sciences, 2018, May-15, Volume: 201

    Topics: Adaptation, Physiological; Animals; Chickens; Circadian Rhythm; CLOCK Proteins; Corticosterone; Diet

2018
Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin.
    The European journal of neuroscience, 2020, Volume: 51, Issue:12

    Topics: Circadian Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Sleep

2020
The embryonic pineal gland of the chicken as a model for experimental jet lag.
    General and comparative endocrinology, 2013, Jul-01, Volume: 188

    Topics: Animals; Chick Embryo; Chickens; Circadian Rhythm; CLOCK Proteins; Jet Lag Syndrome; Light; Melatoni

2013
Perspective: casting light on sleep deficiency.
    Nature, 2013, May-23, Volume: 497, Issue:7450

    Topics: Circadian Rhythm; Electricity; Humans; Jet Lag Syndrome; Lighting; Melatonin; Phototherapy; Sleep De

2013
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice.
    Chronobiology international, 2014, Volume: 31, Issue:2

    Topics: Animals; Behavior, Animal; Chronic Disease; Circadian Rhythm; Circadian Rhythm Signaling Peptides an

2014
Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta).
    Journal of pineal research, 2014, Volume: 56, Issue:3

    Topics: Animals; Circadian Rhythm; Female; Jet Lag Syndrome; Macaca mulatta; Male; Maternal Deprivation; Mel

2014
Changes in melatonin secretion in tourists after rapid movement to another lighting zone without transition of time zone.
    Chronobiology international, 2016, Volume: 33, Issue:2

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Male; Melatonin; Movement; Photoperiod; Travel

2016
Short Blue Light Pulses (30 Min) in the Morning Support a Sleep-Advancing Protocol in a Home Setting.
    Journal of biological rhythms, 2016, Volume: 31, Issue:5

    Topics: Actigraphy; Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Light; Male; Mela

2016
Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice.
    Journal of pineal research, 2017, Volume: 62, Issue:4

    Topics: Animals; Cell Proliferation; Cell Survival; Central Nervous System Depressants; Circadian Rhythm; Co

2017
[Jetlag--prevention and therapy].
    MMW Fortschritte der Medizin, 2008, Apr-10, Volume: 150, Issue:15

    Topics: Acclimatization; Benzodiazepines; Biological Clocks; Humans; Hypnotics and Sedatives; Jet Lag Syndro

2008
Elastic liposomes mediated transdermal delivery of an anti-jet lag agent: preparation, characterization and in vitro human skin transport study.
    Current drug delivery, 2008, Volume: 5, Issue:3

    Topics: Administration, Cutaneous; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Com

2008
Timing light treatment for eastward and westward travel preparation.
    Chronobiology international, 2009, Volume: 26, Issue:5

    Topics: Adult; Biological Clocks; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Light; Male; Melatonin

2009
Hypoxia-induced changes in recovery sleep, core body temperature, urinary 6-sulphatoxymelatonin and free cortisol after a simulated long-duration flight.
    Journal of sleep research, 2009, Volume: 18, Issue:4

    Topics: Adult; Aircraft; Altitude; Body Temperature Regulation; Circadian Rhythm; Humans; Hydrocortisone; Hy

2009
Come fly with me: jet lag and melatonin.
    International journal of clinical practice, 2010, Volume: 64, Issue:2

    Topics: Central Nervous System Depressants; Humans; Jet Lag Syndrome; Melatonin

2010
Effect of BRAND's essence of chicken on the resetting process of circadian clocks in rats subjected to experimental jet lag.
    Molecular biology reports, 2011, Volume: 38, Issue:3

    Topics: Animals; Chickens; Circadian Clocks; CLOCK Proteins; Darkness; Feeding Behavior; Jet Lag Syndrome; L

2011
[How do I adjust the internal clock?].
    MMW Fortschritte der Medizin, 2010, Jul-22, Volume: 152, Issue:28-30

    Topics: Humans; Jet Lag Syndrome; Light; Melatonin; Photoperiod; Travel

2010
[Melatonin].
    Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68 Suppl 7

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Jet Lag Syndrome; Male; Melatoni

2010
[Clinical picture and treatment of jet lag].
    Orvosi hetilap, 2011, Dec-11, Volume: 152, Issue:50

    Topics: Benzhydryl Compounds; Biological Clocks; Caffeine; Central Nervous System Depressants; Central Nervo

2011
Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2012, Volume: 22, Issue:3

    Topics: Athletes; Athletic Performance; Caffeine; Circadian Rhythm; Fatigue; Humans; Hypnotics and Sedatives

2012
The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors.
    Chronobiology international, 2012, Volume: 29, Issue:4

    Topics: Animals; Behavior, Animal; Biological Clocks; Circadian Rhythm; Cryptochromes; Disease Models, Anima

2012
Melatonin.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2012, Nov-20, Volume: 184, Issue:17

    Topics: Humans; Jet Lag Syndrome; Melatonin; Sleep

2012
Blacks (African Americans) have shorter free-running circadian periods than whites (Caucasian Americans).
    Chronobiology international, 2012, Volume: 29, Issue:8

    Topics: Adult; Black or African American; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Light; Male; M

2012
Ask the doctor. I often fly on business from Chicago to Europe. Do you have any tips for managing jet lag?
    Harvard women's health watch, 2012, Volume: 20, Issue:1

    Topics: Circadian Rhythm; Europe; Health Behavior; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melato

2012
Jet lag in athletes after eastward and westward time-zone transition.
    Chronobiology international, 2002, Volume: 19, Issue:4

    Topics: Adult; Blood Pressure; Body Temperature; Hand Strength; Heart Rate; Humans; Hydrocortisone; Jet Lag

2002
Can melatonin prevent or treat jet lag?
    American family physician, 2002, Dec-01, Volume: 66, Issue:11

    Topics: Drug Administration Schedule; Evidence-Based Medicine; Female; Humans; Jet Lag Syndrome; Melatonin;

2002
Information from your family doctor. Jet lag.
    American family physician, 2002, Dec-01, Volume: 66, Issue:11

    Topics: Fluid Therapy; Humans; Jet Lag Syndrome; Melatonin; Sunlight

2002
The prevention and treatment of jet lag.
    BMJ (Clinical research ed.), 2003, Feb-08, Volume: 326, Issue:7384

    Topics: Beverages; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin; Sunlight

2003
Melatonin and jet lag syndrome: experimental model and clinical implications.
    CNS spectrums, 2003, Volume: 8, Issue:2

    Topics: Animals; Circadian Rhythm; Humans; Hypertension; Jet Lag Syndrome; Melatonin; Rats; Rats, Inbred SHR

2003
[Sleep-wake rhythm disorders].
    No to shinkei = Brain and nerve, 2003, Volume: 55, Issue:1

    Topics: Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Sleep; Sleep Disorders, Circadian Rhythm; Sleep S

2003
[Brain and education].
    No to hattatsu = Brain and development, 2003, Volume: 35, Issue:2

    Topics: Adolescent; Body Temperature Regulation; Brain; Child; Child, Preschool; Circadian Rhythm; Humans; J

2003
Melatonin and jet lag.
    Health news (Waltham, Mass.), 2003, Volume: 9, Issue:4

    Topics: Anticoagulants; Drug Interactions; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Time Factors

2003
[Strategies against jet lag].
    Praxis, 2004, Apr-21, Volume: 93, Issue:17

    Topics: Anti-Anxiety Agents; Caffeine; Central Nervous System Stimulants; Complementary Therapies; Homeopath

2004
[Health problems due to night shift work and jetlag].
    Der Internist, 2004, Volume: 45, Issue:9

    Topics: Accidents, Occupational; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Cross-Section

2004
Advancing circadian rhythms before eastward flight: a strategy to prevent or reduce jet lag.
    Sleep, 2005, Volume: 28, Issue:1

    Topics: Adult; Aviation; Body Mass Index; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatoni

2005
Does melatonin improve sleep? Efficacy of melatonin.
    BMJ (Clinical research ed.), 2006, Mar-04, Volume: 332, Issue:7540

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Wake Disorders; Treatment Outcome; Work

2006
Age related changes in the activity-rest circadian rhythms and c-fos expression of ring doves with aging. Effects of tryptophan intake.
    Experimental gerontology, 2006, Volume: 41, Issue:4

    Topics: Activity Cycles; Aging; Animals; Body Temperature Regulation; Circadian Rhythm; Columbidae; Gene Exp

2006
Sleep and intercontinental flights.
    Travel medicine and infectious disease, 2006, Volume: 4, Issue:6

    Topics: Aircraft; Central Nervous System Stimulants; Geography; Humans; Hypnotics and Sedatives; Jet Lag Syn

2006
Jet lag. Getting back in sync.
    Mayo Clinic health letter (English ed.), 2006, Volume: 24, Issue:8

    Topics: Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin

2006
Beating jet lag.
    British journal of sports medicine, 2007, Volume: 41, Issue:6

    Topics: Football; GABA Modulators; Humans; Jet Lag Syndrome; Male; Melatonin; Task Performance and Analysis;

2007
Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:2

    Topics: Adult; Body Temperature; Body Temperature Regulation; Circadian Rhythm; Female; Humans; Jet Lag Synd

2008
Melatonin no panacea for jet lag.
    Health news (Waltham, Mass.), 1999, Oct-25, Volume: 5, Issue:13

    Topics: Humans; Jet Lag Syndrome; Melatonin

1999
Melatonin.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Dec-15, Volume: 56, Issue:24

    Topics: Drug Interactions; Headache; Humans; Jet Lag Syndrome; Melatonin; Neoplasms; Sleep Wake Disorders

1999
De novo jet-lag psychosis.
    The British journal of psychiatry : the journal of mental science, 1999, Volume: 174

    Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Clopenthixol; Female; Humans; Jet Lag Syndrome; Ma

1999
Failure of extraocular light to facilitate circadian rhythm reentrainment in humans.
    Chronobiology international, 2000, Volume: 17, Issue:6

    Topics: Adult; Body Temperature; Circadian Rhythm; Eye; Female; Humans; Jet Lag Syndrome; Light; Male; Melat

2000
Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight.
    Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:3

    Topics: Adult; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Middle Aged; Polysomnography; Sleep St

2000
Resynchronization of blood pressure circadian rhythm after westward trans-7-meridian flight with and without melatonin treatment.
    Aviation, space, and environmental medicine, 2001, Volume: 72, Issue:3

    Topics: Adaptation, Physiological; Adult; Aerospace Medicine; Biomarkers; Blood Pressure; Circadian Rhythm;

2001
Exogenous melatonin, jet lag, and psychosis: preliminary case results.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:3

    Topics: Adult; Antioxidants; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged; Psychotic Disor

2001
Re-entrainment of the circadian rhythms of plasma melatonin in an 11-h eastward bound flight.
    Psychiatry and clinical neurosciences, 2001, Volume: 55, Issue:3

    Topics: Adaptation, Physiological; Adult; Aerospace Medicine; Aviation; Circadian Rhythm; Humans; Jet Lag Sy

2001
Circadian urinary 6-sulphatoxymelatonin, cortisol excretion and locomotor activity in airline pilots during transmeridian flights.
    Journal of pineal research, 2001, Volume: 31, Issue:1

    Topics: Adult; Aircraft; Circadian Rhythm; Humans; Hydrocortisone; Jet Lag Syndrome; Male; Melatonin; Mexico

2001
A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes.
    Journal of pineal research, 2002, Volume: 32, Issue:1

    Topics: Adult; Exercise; Humans; Jet Lag Syndrome; Light; Male; Melatonin; Sleep; Soccer; Sports

2002
Melatonin alleviates jet lag symptoms caused by an 11-hour eastward flight.
    Psychiatry and clinical neurosciences, 2002, Volume: 56, Issue:3

    Topics: Adult; Aviation; Humans; Japan; Jet Lag Syndrome; Male; Melatonin; Middle Aged; New York; Time Facto

2002
Hormonal resynchronisation--an occupational hazard.
    The Lancet. Oncology, 2002, Volume: 3, Issue:6

    Topics: Animals; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Mice; Neoplasms; Occup

2002