melatonin has been researched along with Ischemic Attack, Transient in 24 studies
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin treatment significantly improved tGCI-induced cognitive impairment." | 5.48 | Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. ( Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, DW; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Lee, YL; Park, JH; Won, MH; Yan, BC, 2018) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 5.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| "The effect of nimodipine, mexidol, melatonin, afobazole, 5-hydroxy-adanamtan-2-one, and GABA conjugates with arachidonic acid and docosahexaenoyl dopamine on the cerebral circulation has been studied in intact rats and those with global transient cerebral ischemia, experimental myocardial infarction, and combined vascular pathology of brain and heart." | 3.80 | [Cerebrovascular pharmacology of separate and combined vascular pathology of brain and heart]. ( Gan'shina, TS; Gnezdilova, AV; Gorbunov, AA; Khaĭlov, NA; Kurdiumov, IN; Lebedeva, MA; Maslennikov, DV; Mirzoian, RS, 2014) |
| "Melatonin treatment significantly improved tGCI-induced cognitive impairment." | 1.48 | Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. ( Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, DW; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Lee, YL; Park, JH; Won, MH; Yan, BC, 2018) |
| "Melatonin (30 mg/kg) was administered 30 min before and 2h after ischemia as well as once daily until sacrifice." | 1.40 | Protective effect of melatonin against transient global cerebral ischemia-induced neuronal cell damage via inhibition of matrix metalloproteinase-9. ( Kim, SJ; Lee, SR, 2014) |
| " When combined at a dosage either positively or negatively skewed from each optimal dosage, however, co-treatment caused synergistic neuroprotection." | 1.37 | Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response. ( Chen, HY; Chen, TY; Huang, SY; Hung, YC; Lee, AC; Lee, EJ; Lee, MY; Shen, CC; Tai, SH; Wu, TS, 2011) |
| "Melatonin treatment also maintained AANAT immunoreactivity and its protein levels in the CA1 region after ischemia/reperfusion." | 1.36 | Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia. ( Choi, JH; Hwang, IK; Kim, YM; Kwon, YG; Lee, CH; Park, JH; Park, OK; Won, MH; Yoo, KY, 2010) |
| "Melatonin is a potent free radical scavenger and antioxidant and has protective effects against ischemic damage." | 1.36 | Melatonin's protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor. ( Choi, JH; Hwang, IK; Kim, YM; Kwon, YG; Lee, CH; Park, OK; Won, MH; Yoo, KY, 2010) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 1.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| "Melatonin has been reported to reduce infarct volumes induced by transient middle cerebral artery (MCA) occlusion." | 1.32 | Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats. ( Chang, GL; Chen, TY; Chuang, JI; Lee, EJ; Lee, MY; Tsai, YY; Wu, TS, 2004) |
| "Melatonin treatment diminished the loss of neurons and decreased the infarct volume as compared with untreated MCAO rats." | 1.32 | Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. ( Andrabi, SA; Horn, TF; Sayeed, I; Siemen, D; Wolf, G, 2004) |
| "Melatonin was administered twice (6." | 1.31 | Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. ( Kondoh, T; Nishino, H; Torii, K; Uneyama, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 12 (50.00) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, BH | 1 |
| Park, JH | 2 |
| Lee, YL | 1 |
| Kang, IJ | 1 |
| Kim, DW | 1 |
| Hwang, IK | 3 |
| Lee, CH | 3 |
| Yan, BC | 1 |
| Kim, YM | 3 |
| Lee, TK | 1 |
| Lee, JC | 1 |
| Won, MH | 3 |
| Ahn, JH | 1 |
| Kim, SJ | 1 |
| Lee, SR | 1 |
| Zheng, Y | 1 |
| Hou, J | 1 |
| Liu, J | 1 |
| Yao, M | 1 |
| Li, L | 1 |
| Zhang, B | 1 |
| Zhu, H | 1 |
| Wang, Z | 1 |
| Mirzoian, RS | 1 |
| Gan'shina, TS | 1 |
| Khaĭlov, NA | 1 |
| Gnezdilova, AV | 1 |
| Maslennikov, DV | 1 |
| Kurdiumov, IN | 1 |
| Lebedeva, MA | 1 |
| Gorbunov, AA | 1 |
| Hung, YC | 4 |
| Chen, TY | 8 |
| Lee, EJ | 8 |
| Chen, WL | 1 |
| Huang, SY | 4 |
| Lee, WT | 3 |
| Lee, MY | 6 |
| Chen, HY | 7 |
| Wu, TS | 8 |
| Cam, E | 1 |
| Yulug, B | 1 |
| Cengiz, N | 1 |
| Poelkin, E | 1 |
| Isýk, D | 1 |
| Bakar, M | 1 |
| Ozan, E | 1 |
| Kilic, E | 2 |
| Wang, YH | 1 |
| Ahmad, A | 1 |
| Khan, MM | 1 |
| Ishrat, T | 1 |
| Khan, MB | 1 |
| Khuwaja, G | 1 |
| Raza, SS | 1 |
| Shrivastava, P | 1 |
| Islam, F | 1 |
| Park, OK | 2 |
| Yoo, KY | 2 |
| Choi, JH | 2 |
| Kwon, YG | 2 |
| Tai, SH | 2 |
| Lin, HW | 1 |
| Chen, YH | 1 |
| Lee, AC | 1 |
| Shen, CC | 1 |
| El-Abhar, HS | 1 |
| Shaalan, M | 1 |
| Barakat, M | 1 |
| El-Denshary, ES | 1 |
| Kondoh, T | 1 |
| Uneyama, H | 1 |
| Nishino, H | 1 |
| Torii, K | 1 |
| Pei, Z | 1 |
| Pang, SF | 1 |
| Cheung, RT | 1 |
| Tsai, YY | 1 |
| Chuang, JI | 2 |
| Chang, GL | 2 |
| Andrabi, SA | 1 |
| Sayeed, I | 1 |
| Siemen, D | 1 |
| Wolf, G | 1 |
| Horn, TF | 1 |
| Kuo, YL | 2 |
| Lin, SC | 1 |
| Chen, ST | 2 |
| Hsu, YS | 2 |
| Ondrejicková, O | 1 |
| Rapková, M | 1 |
| Snirc, V | 1 |
| Dubovický, M | 1 |
| Jariabka, P | 1 |
| Zacharová, S | 1 |
| Stolc, S | 1 |
| Kuan, YH | 1 |
| Huang, CC | 1 |
| Yang, IP | 1 |
| Cho, S | 1 |
| Joh, TH | 1 |
| Baik, HH | 1 |
| Dibinis, C | 1 |
| Volpe, BT | 1 |
| Guerrero, JM | 1 |
| Reiter, RJ | 1 |
| Ortiz, GG | 1 |
| Pablos, MI | 1 |
| Sewerynek, E | 1 |
| Ozdemir, YG | 1 |
| Bolay, H | 1 |
| Keleştimur, H | 1 |
| Dalkara, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Center, Open Label Prospective Observational Pilot Study to Evaluate the Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)[NCT05922995] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for melatonin and Ischemic Attack, Transient
| Article | Year |
|---|---|
Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cell Death; Cognitive Dysfuncti | 2018 |
Protective effect of melatonin against transient global cerebral ischemia-induced neuronal cell damage via inhibition of matrix metalloproteinase-9.
Topics: Animals; Antioxidants; Gelatinases; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transie | 2014 |
Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Disease Models, Animal; Gene Expression | 2014 |
[Cerebrovascular pharmacology of separate and combined vascular pathology of brain and heart].
Topics: Adamantane; Animals; Animals, Outbred Strains; Benzimidazoles; Bicuculline; Cerebral Cortex; Dopamin | 2014 |
Melatonin decreases matrix metalloproteinase-9 activation and expression and attenuates reperfusion-induced hemorrhage following transient focal cerebral ischemia in rats.
Topics: Animals; Blotting, Western; Brain; Brain Infarction; Cerebral Hemorrhage; Enzyme Activation; Gene Ex | 2008 |
Melatonin: a suitable agent for depression associated with stroke?
Topics: Animals; Antioxidants; Cerebral Infarction; Depressive Disorder; Humans; Ischemic Attack, Transient; | 2008 |
Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats.
Topics: Animals; Blotting, Western; Body Weight; Dendritic Spines; Gene Expression Regulation; Ischemic Atta | 2009 |
Synergistic effect of selenium and melatonin on neuroprotection in cerebral ischemia in rats.
Topics: Animals; Antioxidants; Glutathione; Ischemic Attack, Transient; Male; Melatonin; Neuroprotective Age | 2011 |
Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Astrocytes; CA1 Region, Hippocampal; Cell Death; Gerbil | 2010 |
Melatonin's protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Disease Models, Animal; Gerbillinae; Ischemic Attack, | 2010 |
Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia.
Topics: Animals; Behavior, Animal; Brain; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fib | 2010 |
Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response.
Topics: Animals; Animals, Newborn; Body Weight; Cell Line; Cells, Cultured; Estrogens; Female; Interleukin-6 | 2011 |
Effect of melatonin and nifedipine on some antioxidant enzymes and different energy fuels in the blood and brain of global ischemic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Blood; Brain; Calcium Channel Blockers; Disease Models | 2002 |
Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain Edema; Coloring Agents; Ischemic Attac | 2002 |
Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats.
Topics: Animals; Behavior, Animal; Body Weight; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatu | 2004 |
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.
Topics: Animals; Apoptosis; Calcium Signaling; Cell Hypoxia; Corpus Striatum; Infarction, Middle Cerebral Ar | 2004 |
Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Infarction, Middle Cerebral Artery; Intracranial Hemor | 2006 |
Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood-brain barrier permeability after transient focal cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Attack | 2006 |
Content of protein carbonyl groups in gerbil brain after reversible bilateral carotid occlusion: effect of 2,3-dihydromelatonin.
Topics: Animals; Arterial Occlusive Diseases; Brain Chemistry; Carotid Arteries; Gerbillinae; Glutathione; I | 2006 |
Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats.
Topics: Animals; Inflammation; Injections, Intravenous; Ischemic Attack, Transient; Leukocytes; Male; Melato | 2007 |
Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats.
Topics: Analysis of Variance; Animals; Free Radical Scavengers; Hippocampus; Ischemic Attack, Transient; Mal | 1997 |
Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus).
Topics: Animals; Brain; Carotid Arteries; Cerebellum; Cerebral Cortex; Constriction; Cyclic GMP; Frontal Lob | 1997 |
Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia.
Topics: Animals; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationshi | 1999 |