melatonin and Injury, Myocardial Reperfusion studies

Research Excerpts

Excerpt	Relevance	Reference
"The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial is an unicenter, prospective, randomized, double-blind, placebo-controlled, phase 2 study of the intravenous administration of melatonin."	9.12	A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An ( Abreu-Gonzalez, P; Dominguez-Rodriguez, A; Garcia-Gonzalez, MJ; Jimenez-Sosa, A; Kaski, JC; Reiter, RJ, 2007)
" Here, we explored the effects of nicotinamide mononucleotide (NMN)/melatonin combination therapy on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury."	8.31	The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury. ( Badalzadeh, R; Hosseini, L; Høilund-Carlsen, PF; Mokhtari, B; Rajabi, M; Salehinasab, R, 2023)
"Healthy rats were selected as the samples and divided into blank group, sepsis group and sepsis + melatonin group."	8.12	Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway. ( Jia, H; Liang, W; Zhen, G; Zheng, X, 2022)
"To investigate the protective effect of melatonin against myocardial ischemia reperfusion (IR) injury in isolated rat hearts and explore the underlying mechanisms."	7.96	[Melatonin protects against myocardial ischemia-reperfusion injury by inhibiting contracture in isolated rat hearts]. ( Chang, L; Chen, Y; Kong, L; Su, X; Sun, N; Wei, L; Zhang, L, 2020)
"Recently, we demonstrated that melatonin reduced protein kinase RNA (PKR)-like ER kinase (PERK)-eukaryotic initiation factor 2 alpha (eIF2α)-activating transcription factor-4 (ATF4)-mediated myocardial endoplasmic reticulum (ER) stress and apoptosis during myocardial ischemia-reperfusion (MI/R) injury."	7.83	Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. ( Chen, W; Duan, W; Jin, Z; Li, B; Liu, J; Liu, Z; Wang, S; Yang, J; Yang, Y; Yi, D; Yu, L; Yu, S; Zhang, M; Zhao, G, 2016)
"Melatonin has cardioprotective properties via its direct free radical scavenging and its indirect antioxidant activity."	6.48	The role of melatonin in acute myocardial infarction. ( Abreu-Gonzalez, P; Avanzas, P; Dominguez-Rodriguez, A, 2012)
"Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed."	5.91	Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023)
" A total of 20 landrace pigs were randomized to a dosage of 200 mg (0."	5.43	Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction. ( Aarøe, J; Ekeløf, SV; Gögenur, I; Halladin, NL; Jensen, SE; Kjærgaard, B; Rosenberg, J; Simonsen, CW; Zaremba, T, 2016)
"Melatonin treatment reduced the BW gain, visceral adiposity, blood TRIG, serum insulin, homeostatic model assessment index and thiobarbituric acid reactive substances in the DIO group."	5.37	Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. ( Blackhurst, D; Du Toit, EF; Lochner, A; Marais, D; Nduhirabandi, F, 2011)
"Melatonin is a well-known antioxidant and free-radical scavenger."	5.34	Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats. ( Atessahin, A; Olmez, E; Sahna, E; Türk, G; Yilmaz, S, 2007)
"Cardiac arrhythmias during ischemia-reperfusion (I/R) are believed to be related to free radicals generated in the heart especially during the period of reperfusion."	5.31	Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? ( Acet, A; Olmez, E; Sahna, E, 2002)
"Pretreatment with melatonin dramatically improved survival rate of rats when compared with the I/R-only group."	5.31	Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. ( Chen, HR; Hsiao, G; Lee, YM; Sheu, JR; Wang, JJ; Yen, MH, 2002)
"The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial is an unicenter, prospective, randomized, double-blind, placebo-controlled, phase 2 study of the intravenous administration of melatonin."	5.12	A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An ( Abreu-Gonzalez, P; Dominguez-Rodriguez, A; Garcia-Gonzalez, MJ; Jimenez-Sosa, A; Kaski, JC; Reiter, RJ, 2007)
" Here, we explored the effects of nicotinamide mononucleotide (NMN)/melatonin combination therapy on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury."	4.31	The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury. ( Badalzadeh, R; Hosseini, L; Høilund-Carlsen, PF; Mokhtari, B; Rajabi, M; Salehinasab, R, 2023)
"Healthy rats were selected as the samples and divided into blank group, sepsis group and sepsis + melatonin group."	4.12	Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway. ( Jia, H; Liang, W; Zhen, G; Zheng, X, 2022)
"Treatment with melatonin at all time points alleviated cardiac I/R injury to a similar extent, quantified by reduction in infarct size, arrhythmia score, LV dysfunction, cardiac mitochondrial dysfunction, imbalance of mitochondrial dynamics, excessive mitophagy, and a decreased Bax/Bcl2 ratio."	4.02	Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Jaiwongkam, T; Kerdphoo, S; Singhanat, K, 2021)
"Pharmacological concentrations of melatonin reduce reperfusion arrhythmias, but less is known about the antiarrhythmic protection of the physiological circadian rhythm of melatonin."	3.96	Reperfusion Arrhythmias Increase after Superior Cervical Ganglionectomy Due to Conduction Disorders and Changes in Repolarization. ( Aguiar, F; Diez, ER; Farias Altamirano, LE; Miatello, RM; Muñoz, EM; Ponce Zumino, AZ; Prado, NJ; Pueyo, E; Sánchez, FJ, 2020)
"To investigate the protective effect of melatonin against myocardial ischemia reperfusion (IR) injury in isolated rat hearts and explore the underlying mechanisms."	3.96	[Melatonin protects against myocardial ischemia-reperfusion injury by inhibiting contracture in isolated rat hearts]. ( Chang, L; Chen, Y; Kong, L; Su, X; Sun, N; Wei, L; Zhang, L, 2020)
"Melatonin pre-treatment protected the heart from MI/R by reducing myocardial oedema and inflammation, attenuating oxidative stress, and decreasing myocardial apoptosis."	3.91	Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway. ( Chen, T; Deng, C; Jules, KED; Lan, H; Li, H; Liu, Y; Masau, JF; Su, Y; Wang, J; Wei, X, 2019)
"Recently, we demonstrated that melatonin reduced protein kinase RNA (PKR)-like ER kinase (PERK)-eukaryotic initiation factor 2 alpha (eIF2α)-activating transcription factor-4 (ATF4)-mediated myocardial endoplasmic reticulum (ER) stress and apoptosis during myocardial ischemia-reperfusion (MI/R) injury."	3.83	Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. ( Chen, W; Duan, W; Jin, Z; Li, B; Liu, J; Liu, Z; Wang, S; Yang, J; Yang, Y; Yi, D; Yu, L; Yu, S; Zhang, M; Zhao, G, 2016)
"To investigate the mechanism of melatonin (MT) protection of adult rate myocardial ischemia-reperfusion injury and its influence on rat's hemodynamic recovery."	3.80	Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats. ( Deng, QC; Liu, LF; Liu, Y; Qian, ZH; Qin, Q; Shi, M; Tao, XM; Zhang, H; Zhu, WP, 2014)
"Pretreatment with melatonin (10 mg/kg) effectively reduced cardiac I/R injury by reducing infarct size, arrhythmia, and LV dysfunction."	3.11	Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats. ( Apaijai, N; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Maneechote, C; Singhanat, K; Sumneang, N, 2022)
"Melatonin has emerged as an anti-inflammatory agent, potent direct free-radical scavenger, and an indirect antioxidant in preventing ischemia-reperfusion injury."	3.11	The effect of melatonin on cardiac biomarkers after coronary artery bypass graft surgery: A double-blind, randomized pilot study. ( Farzam, S; Khezri, MB; Nasseh, N; Shafikhani, AA; Shiravandi, S, 2022)
"The current study revealed that ML and NAC are potent antioxidants with similar efficacy in terms of reducing CABG related cardiac injury and oxidative stress with the dosage employed for the intervention."	2.87	Effects of N-acetyl cysteine and melatonin on early reperfusion injury in patients undergoing coronary artery bypass grafting: A randomized, open-labeled, placebo-controlled trial. ( Akbarzadeh, S; Anvaripour, A; Bahtoei, M; Iranpour, D; Movahed, A; Netticadan, T; Ostovar, A; Raj, P; Shafiei, E; Shahryari, H; Tahmasebi, R, 2018)
"A total of 146 patients presenting with STEMI within 6 hours of chest pain onset were randomized to receive intravenous and intracoronary melatonin (n=73) or placebo (n=73) during primary percutaneous coronary intervention (PPCI)."	2.84	Effect of intravenous and intracoronary melatonin as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: Results of the Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty trial. ( Abreu-Gonzalez, P; Aldea-Perona, A; Azpeitia, A; Consuegra-Sanchez, L; de la Torre-Hernandez, JM; Dominguez-Rodriguez, A; Garcia-Camarero, T; Garcia-Saiz, MD; Gonzalez-Gonzalez, J; Reiter, RJ; Virgos-Aller, T, 2017)
"Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies."	2.84	Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. ( Aarøe, J; Ekeloef, S; Fonnes, S; Gasbjerg, LS; Gögenur, I; Halladin, N; Jensen, SE; Jonsson, G; Rosenberg, J; Rosenkilde, MM; Zaremba, T, 2017)
"Melatonin was identified to exert protective effects for alleviating the myocardial I/R injury."	2.66	Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. ( Chen, YH; Huang, ZQ; Lin, H; Mao, ZJ; Xiao, FY, 2020)
"Melatonin is a hormone that is produced by the pineal gland, and it plays an important role in regulating many physiological functions in human body."	2.58	Roles of melatonin and its receptors in cardiac ischemia-reperfusion injury. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Singhanat, K, 2018)
"Melatonin is a pleiotropic hormone with several functions."	2.58	Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review. ( Huisamen, B; Lochner, A; Marais, E, 2018)
"Melatonin has been effectively used to combat oxidative stress, inflammation and cellular apoptosis and to restore tissue function in a number of human trials; its efficacy supports its more extensive use in a wider variety of human studies."	2.53	Melatonin as an antioxidant: under promises but over delivers. ( Alatorre-Jimenez, M; Mayo, JC; Qin, L; Reiter, RJ; Sainz, RM; Tan, DX, 2016)
"Melatonin has cardioprotective properties via its direct free radical scavenging and its indirect antioxidant activity."	2.48	The role of melatonin in acute myocardial infarction. ( Abreu-Gonzalez, P; Avanzas, P; Dominguez-Rodriguez, A, 2012)
"Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed."	1.91	Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023)
"Melatonin posttreatment (t = -15, 0, 5, 10, 15, and 30 min) significantly inhibited excessive mitophagy after A/R injury, reduced cellular apoptosis and oxidative stress, restored mitochondrial function and MMP, and restrained mPTP opening."	1.72	Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells. ( Bai, Y; Cui, B; Lin, D; Ma, J; Wang, Z; Yang, Y, 2022)
"Melatonin has been implicated in attenuating I/R-induced injury of cardiomyocytes."	1.72	Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis. ( Chen, R; Yang, M, 2022)
"Melatonin was added to the perfusion solution five minutes prior to and until 15 min after the start of reperfusion."	1.62	Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. ( Badalzadeh, R; Feyzizadeh, S; Hosseini, L; Høilund-Carlsen, PF; Jafari-Azad, A; Rajabi, M; Vafaee, MS, 2021)
"The mechanism of reentrant ventricular tachyarrhythmias complicating acute myocardial ischemia is largely based on the interaction between an arrhythmogenic substrate and triggers."	1.62	Melatonin pretreatment does not modify extrasystolic burden in the rat ischemia-reperfusion model. ( Azarov, JE; Bernikova, OG; Durkina, AV; Gonotkov, MA; Kuzmin, VS; Mikhaleva, NJ; Paderin, NM; Sedova, KA, 2021)
"Melatonin treatment caused a significant reduction in infarct size in hearts from both control and diet groups."	1.56	Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. ( Dhanabalan, K; Huisamen, B; Lochner, A; Mzezewa, S, 2020)
"Melatonin was given before ischemia (UI80 + M1, HTK80 + M1) or before and after ischemia (UI80 + M2, HTK80 + M2)."	1.51	The effect of melatonin on hearts in ischemia/reperfusion experiments without and with HTK cardioplegia. ( Gebhard, MM; Gross, W; Schaefer, M, 2019)
"Pretreatment with melatonin partially reversed these alterations and promoted Nrf2 nuclear translocation."	1.48	Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. ( Gao, F; Miao, S; Qiao, B; Wang, H; Zhang, Y; Zhao, H, 2018)
"Melatonin has been demonstrated to protect cardiac microvascular endothelial cells (CMECs) against ischemia/reperfusion injury (IRI)."	1.48	Melatonin Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy Via an AMPK/mTOR Signaling Pathway. ( Chen, WR; Chen, YD; Liu, HB; Ma, Q; Mu, Y; Sha, Y; Zhu, PJ, 2018)
"Melatonin induced lower IP3R and higher SERCA2a expression in myocardium that were reversed by PD98059."	1.48	Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1. ( Chen, Y; Hu, S; Zhang, Y; Zhou, H; Zhu, P, 2018)
"Melatonin treatment significantly increased myocardial Sirt3 expression, and alleviated MI/R-induced cardiac morphology changes and cardiac dysfunction, as well as myocardial apoptosis level."	1.48	Melatonin protects against myocardial ischemia-reperfusion injury by elevating Sirtuin3 expression and manganese superoxide dismutase activity. ( Cao, C; Chen, X; Feng, J; Liu, R; Nie, S; Zhang, W; Zhao, Y, 2018)
"Stress hyperglycemia is commonly observed in patients suffering from ischemic heart disease."	1.46	Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner. ( Fan, C; Li, Z; Wang, H; Xu, Y; Xue, X; Yang, Y; Yu, L; Zhang, J; Zhao, G, 2017)
"Melatonin was administered intraperitoneally (20 mg/kg) 10 minutes before reperfusion."	1.46	Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. ( Duan, W; Gao, E; Jin, Z; Jing, L; Li, B; Liang, H; Liu, Z; Ren, K; Yang, Y; Yu, B; Yu, L; Yu, S; Zhai, M; Zhang, B; Zhang, M, 2017)
" A total of 20 landrace pigs were randomized to a dosage of 200 mg (0."	1.43	Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction. ( Aarøe, J; Ekeløf, SV; Gögenur, I; Halladin, NL; Jensen, SE; Kjærgaard, B; Rosenberg, J; Simonsen, CW; Zaremba, T, 2016)
"Melatonin treatment up-regulated SIRT1 expression, reduced oxidative damage, and suppressed PERK/eIF2α/ATF4 signaling."	1.42	Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. ( Chen, W; Dong, X; Duan, W; Jin, Z; Liang, H; Liu, J; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, L; Yu, S; Zhai, M; Zhao, G, 2015)
"Melatonin treatment also resulted in reduced myocardium superoxide generation, gp91(phox) expression, malondialdehyde level, and increased myocardium superoxide dismutase (SOD) level, which indicate that the MI/R-induced oxidative stress was significantly attenuated."	1.40	Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1. ( Cheng, L; Duan, W; Jin, Z; Meng, Q; Pei, H; Sun, Y; Wang, X; Yang, Y; Yu, L; Yu, S; Zhai, M; Zhang, H; Zhang, Y, 2014)
" In isolated neonatal coronary arteries, endothelium-dependent nitric oxide (NO) bioavailability was reduced in IUGR, and was rescued by modest melatonin treatment."	1.40	Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs. ( Coleman, HA; Jenkin, G; Lim, R; Miller, SL; Parkington, HC; Sutherland, AE; Tare, M; Wallace, EM; Yawno, T, 2014)
"Melatonin has potent activity against IRI and may regulate JAK2/STAT3 signaling."	1.39	JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. ( Chen, W; Duan, W; Jin, Z; Li, Y; Liang, Z; Wang, N; Yan, J; Yang, Y; Yi, D; Yi, W; Yu, S; Zhang, S, 2013)
"Melatonin treatment reduced the BW gain, visceral adiposity, blood TRIG, serum insulin, homeostatic model assessment index and thiobarbituric acid reactive substances in the DIO group."	1.37	Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. ( Blackhurst, D; Du Toit, EF; Lochner, A; Marais, D; Nduhirabandi, F, 2011)
"Melatonin has potent cardioprotective properties."	1.35	Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. ( Genade, S; Genis, A; Huisamen, B; Lochner, A; Ytrehus, K, 2008)
"Melatonin is an efficient free-radical scavenger and induces the expression of antioxidant enzymes."	1.35	Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. ( Chen, Z; Chua, BH; Chua, CC; Chua, KW; Gao, J; Hamdy, RC; Ho, YS, 2009)
"Melatonin is a potent scavenger of free radicals and an antioxidant."	1.35	Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? ( Aka, SA; Bilgen, F; Deniz, H; Kurç, E; Sanioğlu, S; Sargin, M; Sokullu, O; Tartan, Z, 2009)
"Melatonin treatment significantly improves the functional recovery of Langerdoff hearts on reperfusion, reduces the infarct size, and decreases necrotic damage as shown by the reduced release of lactate dehydrogenase."	1.35	Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. ( Colantuono, G; Di Venosa, N; Fiore, T; Moro, N; Paradies, G; Petrosillo, G; Ruggiero, FM; Tiravanti, E, 2009)
"Malondialdehyde levels were also increased in the heart of hypoxic rats and were lowered by the treatment of melatonin."	1.35	Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. ( Fung, ML; Hung, MW; Yeung, HM, 2008)
"Melatonin is a well-known antioxidant and free-radical scavenger."	1.34	Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats. ( Atessahin, A; Olmez, E; Sahna, E; Türk, G; Yilmaz, S, 2007)
"Melatonin or vehicle was given 10 min before ischemia."	1.34	Investigating the protective effect of melatonin on liver injury related to myocardial ischemia-reperfusion. ( Acet, A; Cigremis, Y; Colak, C; Ozer, MK; Parlakpinar, H; Sahna, E, 2007)
"Melatonin was more efficient in reducing MDA levels than CAPE (P < 0."	1.33	Effects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in rats. ( Acet, A; Eşrefoğlu, M; Gül, M; Parlakpinar, H, 2005)
" Long-term administration of melatonin (i."	1.33	Short- and long-term effects of melatonin on myocardial post-ischemic recovery. ( Davids, A; Genade, S; Lochner, A; Moolman, JA; Ytrehus, K, 2006)
"Melatonin has been shown to effectively protect against ischemic-reperfusion myocardial damage."	1.33	Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin. ( Casanova, G; Colantuono, G; Di Venosa, N; Federici, A; Paradies, G; Petrosillo, G; Pistolese, M; Ruggiero, FM; Tiravanti, E, 2006)
"Reduction in the synthesis or bioavailability of nitric oxide plays a significant role in the development of myocardial infarction and hypertension."	1.33	Nitric oxide synthase inhibition in rats: melatonin reduces blood pressure and ischemia/reperfusion-induced infarct size. ( Aksulu, HE; Deniz, E; Sahna, E, 2006)
"As melatonin levels have been reported to decrease with age, melatonin replacement therapy may attenuate I/R-induced myocardial injury, especially in older patients."	1.31	Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. ( Acet, A; Olmez, E; Ozer, MK; Sahna, E, 2002)
"Melatonin has been found to be effective in protecting against pathological states due to reactive oxygen species release."	1.31	Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. ( Demenge, P; Godin-Ribuot, D; Joyeux, M; Lagneux, C; Ribuot, C, 2000)
"Melatonin was added to the perfusion medium 5 min before ischemia at concentrations of 10 micromol/l or 10 nmol/l and was present throughout the experiment."	1.31	Effects of melatonin on ischemia and reperfusion injury of the rat heart. ( Asemu, G; Kolár, F; Ost'ádal, B; Szárszoi, O; Vanecek, J, 2001)
"Cardiac arrhythmias during ischemia-reperfusion (I/R) are believed to be related to free radicals generated in the heart especially during the period of reperfusion."	1.31	Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? ( Acet, A; Olmez, E; Sahna, E, 2002)
"Pretreatment with melatonin dramatically improved survival rate of rats when compared with the I/R-only group."	1.31	Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. ( Chen, HR; Hsiao, G; Lee, YM; Sheu, JR; Wang, JJ; Yen, MH, 2002)

Research

Studies (109)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Number of Participants With Delayed Recovery of Liver Function

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	34 (31.19)	29.6817
2010's	47 (43.12)	24.3611
2020's	28 (25.69)	2.80

Authors	Studies
Kong, L	2
Xu, C	1
Sun, N	2
Liang, F	1
Wei, M	1
Su, X	2
Bai, Y	1
Yang, Y	13
Cui, B	1
Lin, D	1
Wang, Z	1
Ma, J	1
Lv, T	1
Yan, J	2
Lou, Y	1
Zhang, Z	1
Ye, M	1
Zhou, J	1
Luo, F	1
Bi, C	1
Lin, H	2
Zhang, J	3
Guo, H	1
Liu, Z	3
Chen, R	1
Yang, M	1
Singhanat, K	3
Apaijai, N	3
Sumneang, N	1
Maneechote, C	1
Arunsak, B	1
Chunchai, T	1
Chattipakorn, SC	3
Chattipakorn, N	3
Nasseh, N	1
Khezri, MB	1
Farzam, S	1
Shiravandi, S	1
Shafikhani, AA	1
Chen, JY	1
Li, T	1
Wang, JL	1
Wang, ZL	1
Zhang, Y	8
Zang, LQ	1
Wang, Y	5
Wang, SJ	3
Fang, SH	3
Yu, B	4
Mokhtari, B	2
Høilund-Carlsen, PF	3
Chodari, L	1
Yasami, M	1
Badalzadeh, R	4
Ghaffari, S	1
Hosseini, L	3
Salehinasab, R	1
Rajabi, M	2
Zhang, H	4
Li, S	1
Jin, Y	1
Vafaee, MS	2
Aslan, G	1
Gül, HF	1
Tektemur, A	1
Sahna, E	9
Prado, NJ	1
Muñoz, EM	1
Farias Altamirano, LE	1
Aguiar, F	1
Ponce Zumino, AZ	1
Sánchez, FJ	1
Miatello, RM	2
Pueyo, E	1
Diez, ER	2
Qi, X	1
Wang, J	3
Zhi, W	1
Li, K	1
Wang, H	5
Lei, M	1
Guo, Y	2
Zhang, C	2
Yang, JB	2
Quan, W	1
Feng, YD	1
Feng, JY	1
Cheng, LS	1
Li, XQ	1
Zhang, HN	1
Chen, WS	2
Dhanabalan, K	1
Mzezewa, S	1
Huisamen, B	3
Lochner, A	5
Zhen, G	1
Liang, W	1
Jia, H	1
Zheng, X	1
Mao, ZJ	1
Xiao, FY	1
Huang, ZQ	1
Chen, YH	1
Bernikova, OG	2
Vaykshnorayte, MA	1
Ovechkin, AO	1
Sedova, KA	2
Kharin, SN	1
Azarov, JE	2
Randhawa, PK	1
Gupta, MK	1
Wei, L	1
Zhang, L	2
Chen, Y	7
Chang, L	1
Yu, LM	1
Dong, X	2
Xue, XD	1
Xu, S	1
Zhang, X	1
Xu, YL	1
Wang, ZS	1
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Liang, YX	1
Wang, HS	1
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Durkina, AV	1
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Wang, L	1
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Yang, X	1
Zheng, J	1
Zhou, H	5
Hu, S	5
Shi, C	1
Zhu, P	5
Ma, Q	4
Jin, Q	1
Cao, F	2
Tian, F	2
Zhai, M	4
Li, B	3
Duan, W	7
Jing, L	1
Zhang, B	1
Zhang, M	4
Yu, L	7
Ren, K	1
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Liang, H	3
Jin, Z	7
Yu, S	7
Li, D	2
Hu, N	1
Ma, S	2
Han, T	1
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Ekeloef, S	1
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Zhang, W	1
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Xu, J	1
Fu, Z	1
Lan, H	1
Su, Y	2
Liu, Y	2
Deng, C	1
Chen, T	1
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Gross, W	1
Wang, S	2
Bian, W	1
Zhen, J	1
Zhao, L	1
Chen, W	5
Kang, YM	1
Yu, XJ	1
Yi, W	3
Zhang, S	1
Wang, N	1
Liang, Z	1
Li, Y	2
Yi, D	5
Tare, M	1
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Wallace, EM	1
Sutherland, AE	1
Lim, R	1
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Cheng, L	1
Pei, H	1
Wang, X	2
Meng, Q	1
Fan, C	3
Xin, Z	1
Jiang, S	1
Di, S	1
Qu, Y	1
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Halladin, NL	2
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Zhu, WP	2
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Yang, J	3
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Melatonin on Reperfusion Injury in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention[NCT03303378]		190 participants (Anticipated)	Interventional	2017-11-01	Recruiting
The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435]		160 participants (Actual)	Interventional	2016-08-22	Completed
The Intervention Effect Of Melatonin On The Risk Of Cardiovascular Events And Malignant Tumors In The Elderly: A Prospective, Randomized Parallel Controlled Study Based On Large Cohorts[NCT04631341]		10,000 participants (Anticipated)	Interventional	2021-01-01	Not yet recruiting
Randomized, Double-blind, Parallel-group, Placebo-controlled Study of Melatonin as an Adjunct in Patients With Acute myocaRdial Infarction Undergoing Primary Angioplasty[NCT00640094]	Phase 2	272 participants (Actual)	Interventional	2013-05-31	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days

Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days

Intervention	Participants (Count of Participants)
RIPC	5
Control	0

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation

Postoperative Liver Regeneration

Intervention	IU/L (Mean)
RIPC	145
Control	152

The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month

The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days

Intervention	percentage of liver volume (Mean)
RIPC	83.3
Control	94.9

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation

Article	Year
Evaluation of Melatonin Therapy in Patients with Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis. Oxidative medicine and cellular longevity, 2022, Volume: 2022 Topics: Antioxidants; Female; Humans; Male; Melatonin; Middle Aged; Myocardial Reperfusion Injury	2022
Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Animals; Disease Models, Animal; Melatonin; Mice; Myocardial Reperfusion Injury; Rats	2020
Melatonin as a protective agent in cardiac ischemia-reperfusion injury: Vision/Illusion? European journal of pharmacology, 2020, Oct-15, Volume: 885 Topics: Animals; Antioxidants; Free Radical Scavengers; Humans; Melatonin; Myocardial Reperfusion Injury; Re	2020
Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy. Journal of pineal research, 2018, Volume: 64, Issue:3 Topics: Animals; Antioxidants; Humans; Melatonin; Myocardial Reperfusion Injury	2018
Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review. Journal of pineal research, 2018, Volume: 65, Issue:1 Topics: Animals; Humans; Melatonin; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial P	2018
Roles of melatonin and its receptors in cardiac ischemia-reperfusion injury. Cellular and molecular life sciences : CMLS, 2018, Volume: 75, Issue:22 Topics: Animals; Humans; Melatonin; Myocardial Infarction; Myocardial Reperfusion Injury; Protein Kinases; R	2018
A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. Journal of pineal research, 2014, Volume: 57, Issue:4 Topics: Animals; Antioxidants; Humans; Melatonin; Myocardial Reperfusion Injury	2014
Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries. Danish medical journal, 2015, Volume: 62, Issue:4 Topics: Angioplasty, Balloon, Coronary; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Infla	2015
Melatonin as an antioxidant: under promises but over delivers. Journal of pineal research, 2016, Volume: 61, Issue:3 Topics: Animals; Antioxidants; Apoptosis; Humans; Melatonin; Myocardial Reperfusion Injury; Oxidative Stress	2016
Clinical aspects of melatonin in the acute coronary syndrome. Current vascular pharmacology, 2009, Volume: 7, Issue:3 Topics: Acute Coronary Syndrome; Animals; Cardiovascular System; Coronary Artery Disease; Humans; Melatonin;	2009
The role of melatonin in acute myocardial infarction. Frontiers in bioscience (Landmark edition), 2012, 06-01, Volume: 17, Issue:7 Topics: Animals; Cardiotonic Agents; Circadian Rhythm; Coronary Artery Disease; Humans; Melatonin; Models, C	2012
Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovascular research, 2003, Apr-01, Volume: 58, Issue:1 Topics: Aged; Animals; Antioxidants; Humans; Melatonin; Models, Animal; Myocardial Reperfusion Injury; Myoca	2003
[Myocardial ischemia-reperfusion injury and melatonin]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2006, Volume: 6, Issue:2 Topics: Free Radical Scavengers; Humans; Melatonin; Myocardial Reperfusion Injury	2006
Melatonin in cardiac ischemia/reperfusion-induced mitochondrial adaptive changes. Cardiovascular & hematological disorders drug targets, 2007, Volume: 7, Issue:3 Topics: Adaptation, Physiological; Animals; Antioxidants; Humans; Melatonin; Mitochondria, Heart; Myocardial	2007

Article	Year
Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats. Cellular and molecular life sciences : CMLS, 2022, May-19, Volume: 79, Issue:6 Topics: Animals; Melatonin; Myocardial Reperfusion Injury; Obesity; Prediabetic State; Rats; Rats, Wistar	2022
The effect of melatonin on cardiac biomarkers after coronary artery bypass graft surgery: A double-blind, randomized pilot study. Journal of cardiothoracic and vascular anesthesia, 2022, Volume: 36, Issue:10 Topics: Biomarkers; C-Reactive Protein; Coronary Artery Bypass; Double-Blind Method; Humans; Melatonin; Myoc	2022
Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. Journal of cardiovascular translational research, 2017, Volume: 10, Issue:5-6 Topics: Aged; Biomarkers; Cardiovascular Agents; Denmark; Double-Blind Method; Female; Humans; Infusions, In	2017
Effects of N-acetyl cysteine and melatonin on early reperfusion injury in patients undergoing coronary artery bypass grafting: A randomized, open-labeled, placebo-controlled trial. Medicine, 2018, Volume: 97, Issue:30 Topics: Acetylcysteine; Adult; Aged; Antioxidants; Cardiotonic Agents; Coronary Artery Bypass; Coronary Dise	2018
Melatonin effects on myocardial ischemia-reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery. International journal of cardiology, 2016, Oct-15, Volume: 221 Topics: Antioxidants; Coronary Artery Bypass; Coronary Disease; Drug Monitoring; Female; Heart Rate; Humans;	2016
Effect of intravenous and intracoronary melatonin as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: Results of the Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty trial. Journal of pineal research, 2017, Volume: 62, Issue:1 Topics: Angioplasty, Balloon, Coronary; Female; Humans; Male; Melatonin; Middle Aged; Myocardial Reperfusion	2017
A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An Contemporary clinical trials, 2007, Volume: 28, Issue:4 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Antioxidants; Area Under Curve; Cause of Death; Combine	2007
A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An Contemporary clinical trials, 2007, Volume: 28, Issue:4 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Antioxidants; Area Under Curve; Cause of Death; Combine	2007
A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An Contemporary clinical trials, 2007, Volume: 28, Issue:4 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Antioxidants; Area Under Curve; Cause of Death; Combine	2007
A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with An Contemporary clinical trials, 2007, Volume: 28, Issue:4 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Antioxidants; Area Under Curve; Cause of Death; Combine	2007

Article	Year
[Melatonin alleviates myocardial ischemia-reperfusion injury in mice by inhibiting inflammatory response Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021, Aug-20, Volume: 41, Issue:8 Topics: Animals; Melatonin; Mice; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; Signal	2021
Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells. Cell biology international, 2022, Volume: 46, Issue:4 Topics: Apoptosis; Humans; Hypoxia; Melatonin; Mitophagy; Myocardial Reperfusion Injury; Myocytes, Cardiac	2022
Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis. International heart journal, 2022, Volume: 63, Issue:2 Topics: Glucose; Humans; Melatonin; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxygen; Pyr	2022
Protective Effects and Mechanisms of Melatonin on Stress Myocardial Injury in Rats. Journal of cardiovascular pharmacology, 2022, 09-01, Volume: 80, Issue:3 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Glucose; Body Weight; Caspase 3; Creatine Kina	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
[Research progress on improving mitochondrial quality control and attenuating myocardial ischemia-reperfusion injury by melatonin]. Zhonghua xin xue guan bing za zhi, 2022, Nov-24, Volume: 50, Issue:11 Topics: Humans; Melatonin; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury	2022
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. Molecular biology reports, 2023, Volume: 50, Issue:4 Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Infarction; Ischemia; Male; Mel	2023
The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:8 Topics: Animals; Autophagy; Male; Melatonin; MicroRNAs; Myocardial Reperfusion Injury; Nicotinamide Mononucl	2023
Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway. Acta cirurgica brasileira, 2023, Volume: 38 Topics: Animals; Ischemia; Ischemic Preconditioning; Ischemic Preconditioning, Myocardial; KATP Channels; Me	2023
Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats. Journal of cardiovascular pharmacology and therapeutics, 2020, Volume: 25, Issue:3 Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Isolated Hea	2020
Ischemic postconditioning reduced myocardial ischemia-reperfusion injury: The roles of melatonin and uncoupling protein 3. Anatolian journal of cardiology, 2020, Volume: 23, Issue:1 Topics: Animals; Disease Models, Animal; Ischemic Postconditioning; Male; Melatonin; Myocardial Reperfusion	2020
Reperfusion Arrhythmias Increase after Superior Cervical Ganglionectomy Due to Conduction Disorders and Changes in Repolarization. International journal of molecular sciences, 2020, Mar-06, Volume: 21, Issue:5 Topics: Animals; Arrhythmias, Cardiac; Circadian Rhythm; Connexin 43; Ganglionectomy; Heart; Male; Melatonin	2020
Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage. Aging, 2020, 04-19, Volume: 12, Issue:8 Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Disease Models, Animal; Gene Expression Regula	2020
Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC‑1α/Nrf2 signaling. International journal of molecular medicine, 2020, Volume: 45, Issue:5 Topics: Animals; Antioxidants; Apoptosis; Cell Line; Glucose; Melatonin; Membrane Potential, Mitochondrial;	2020
Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury. Journal of cardiovascular pharmacology, 2020, Volume: 76, Issue:2 Topics: Animals; Astrocytes; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Glucose; Heart; Male; Me	2020
Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. Cardiovascular drugs and therapy, 2020, Volume: 34, Issue:6 Topics: Animals; Antioxidants; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Male; Melatonin; Mit	2020
Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway. Minerva medica, 2022, Volume: 113, Issue:6 Topics: Animals; Apoptosis; Heart Injuries; Janus Kinase 2; Melatonin; Myocardial Reperfusion Injury; Rats;	2022
Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia. Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:3 Topics: Animals; Cardiac Electrophysiology; Heart; Male; Melatonin; Myocardial Ischemia; Myocardial Reperfus	2020
[Melatonin protects against myocardial ischemia-reperfusion injury by inhibiting contracture in isolated rat hearts]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020, Jul-30, Volume: 40, Issue:7 Topics: Animals; Contracture; Male; Melatonin; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardiu	2020
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6. Journal of pineal research, 2021, Volume: 70, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2;	2021
Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection. Journal of advanced research, 2021, Volume: 29 Topics: Animals; Apoptosis; Arrhythmias, Cardiac; Autophagy; Cardiotonic Agents; Cell Line; Cell Survival; M	2021
Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. Molecular biology reports, 2021, Volume: 48, Issue:4 Topics: Aging; Animals; Apoptosis; Drug Combinations; Forkhead Box Protein O1; Heart; Male; Melatonin; Myoca	2021
Melatonin pretreatment does not modify extrasystolic burden in the rat ischemia-reperfusion model. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2021, Volume: 72, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Electrocardiography; Heart Rate; Male; Mela	2021
Melatonin Attenuates Cardiac Ischemia-Reperfusion Injury through Modulation of IP3R-Mediated Mitochondria-ER Contact. Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Animals; Antioxidants; Endoplasmic Reticulum Stress; Hypoxia; Inositol 1,4,5-Trisphosphate Receptors	2021
Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis. Journal of pineal research, 2017, Volume: 63, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Heart; Hexokinase; Immunohistochemistry;	2017
Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. Journal of pineal research, 2017, Volume: 63, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Male; Melatonin; Mice; Myocardial Reperfu	2017
Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways. Journal of pineal research, 2017, Volume: 63, Issue:4 Topics: Animals; Melatonin; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Mitophagy; Myoc	2017
Future strategies for acute cardioprotection: 'melatonin as promising therapy'. Cardiovascular research, 2017, 09-01, Volume: 113, Issue:11 Topics: Cardiology; Heart; Humans; Melatonin; Myocardial Reperfusion Injury	2017
Cardioprotective Effects of Melatonin in Reperfusion Injury. Arquivos brasileiros de cardiologia, 2018, Volume: 110, Issue:1 Topics: Antioxidants; Humans; Melatonin; Myocardial Reperfusion Injury; Reperfusion Injury	2018
Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1. Arquivos brasileiros de cardiologia, 2018, Volume: 110, Issue:1 Topics: Animals; Disease Models, Animal; Inositol 1,4,5-Trisphosphate Receptors; Male; MAP Kinase Signaling	2018
Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury. Journal of pineal research, 2018, Volume: 65, Issue:3 Topics: Animals; Coronary Vessels; Cyclophilins; Melatonin; Mice; Mice, Knockout; Microvessels; Mitochondria	2018
Melatonin Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy Via an AMPK/mTOR Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 47, Issue:5 Topics: AMP-Activated Protein Kinases; Animals; Melatonin; Myocardial Reperfusion Injury; Myocardium; Rats;	2018
Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Molecular medicine reports, 2018, Volume: 18, Issue:3 Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cell Line; Cell Survival; Cells, Cultured; Melatonin; M	2018
Melatonin protects against myocardial ischemia-reperfusion injury by elevating Sirtuin3 expression and manganese superoxide dismutase activity. Free radical research, 2018, Volume: 52, Issue:8 Topics: Animals; Echocardiography; Humans; Melatonin; Mice; Myocardial Reperfusion Injury; Oxidative Stress;	2018
Melatonin Attenuates Cardiac Reperfusion Stress by Improving OPA1-Related Mitochondrial Fusion in a Yap-Hippo Pathway-Dependent Manner. Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Cell Cycle Proteins; Cells, Cultured; Dise	2019
Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways. Journal of pineal research, 2019, Volume: 66, Issue:2 Topics: Adenylate Kinase; Animals; GTP Phosphohydrolases; Melatonin; Mice; Mice, Knockout; Mitochondrial Dyn	2019
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway. Life sciences, 2019, Jul-01, Volume: 228 Topics: Animals; Antioxidants; Heart; Heart Transplantation; Inflammation; Janus Kinase 2; Male; Melatonin;	2019
Physiological and pharmacological effects of melatonin on remote ischemic perconditioning after myocardial ischemia-reperfusion injury in rats: Role of Cybb, Fas, NfκB, Irisin signaling pathway. Journal of pineal research, 2019, Volume: 67, Issue:2 Topics: Animals; fas Receptor; Fibronectins; Ischemic Preconditioning; Male; Melatonin; Myocardial Reperfusi	2019
The effect of melatonin on hearts in ischemia/reperfusion experiments without and with HTK cardioplegia. Bioelectrochemistry (Amsterdam, Netherlands), 2019, Volume: 129 Topics: Animals; Cardioplegic Solutions; Female; Free Radical Scavengers; Guinea Pigs; Heart; Heart Arrest,	2019
Melatonin-Mediated Pak2 Activation Reduces Cardiomyocyte Death Through Suppressing Hypoxia Reoxygenation Injury-Induced Endoplasmic Reticulum Stress. Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Calcium Signaling; Cell Hypoxia; Cells, Cultured;	2019
Infusion of Melatonin Into the Paraventricular Nucleus Ameliorates Myocardial Ischemia-Reperfusion Injury by Regulating Oxidative Stress and Inflammatory Cytokines. Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Inflammation Med	2019
JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. Journal of pineal research, 2013, Volume: 55, Issue:3 Topics: Animals; Antioxidants; Apoptosis; Enzyme Inhibitors; Janus Kinase 2; Male; Melatonin; Mitochondria,	2013
Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs. The Journal of physiology, 2014, Jun-15, Volume: 592, Issue:12 Topics: Animals; Cardiotonic Agents; Coronary Circulation; Endothelium, Vascular; Female; Fetal Growth Retar	2014
Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1. Journal of pineal research, 2014, Volume: 57, Issue:2 Topics: Animals; Apoptosis; Carbazoles; Caspase 3; L-Lactate Dehydrogenase; Male; Melatonin; Myocardial Repe	2014
Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction. Heart and vessels, 2016, Volume: 31, Issue:1 Topics: Angioplasty, Balloon, Coronary; Animals; Antioxidants; Disease Models, Animal; Female; Magnetic Reso	2016
Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats. European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:23 Topics: Animals; Apoptosis; Cardiotonic Agents; Hemodynamics; Melatonin; Myocardial Ischemia; Myocardial Rep	2014
Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore. Genetics and molecular research : GMR, 2015, Jul-06, Volume: 14, Issue:3 Topics: Animals; Male; Melatonin; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Tran	2015
Membrane receptor-dependent Notch1/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studies. Journal of pineal research, 2015, Volume: 59, Issue:4 Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Caspase 3; Cell Line; Homeodomain	2015
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. Journal of pineal research, 2015, Volume: 59, Issue:3 Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Male; Melatonin; Myocardial Reperfusion Injury	2015
Role of toll-like receptor 4 in melatonin-induced cardioprotection. Journal of pineal research, 2016, Volume: 60, Issue:1 Topics: Animals; Cardiotonic Agents; Male; Melatonin; Mice; Mice, Knockout; Myocardial Reperfusion Injury; M	2016
The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury. Journal of pineal research, 2016, Volume: 60, Issue:3 Topics: Animals; Apoptosis; Melatonin; Mice; Mice, Transgenic; Myocardial Reperfusion Injury; Myocardium; Nu	2016
Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. Apoptosis : an international journal on programmed cell death, 2016, Volume: 21, Issue:7 Topics: Activating Transcription Factor 4; Animals; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic I	2016
Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1. Journal of pineal research, 2017, Volume: 62, Issue:1 Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; In Situ Nick-End Labeling; Melatonin;	2017
Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression. Journal of pineal research, 2017, Volume: 62, Issue:1 Topics: Animals; Apoptosis; Disease Models, Animal; Gene Knockdown Techniques; Male; Melatonin; Mice; Mice,	2017
Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner. Journal of pineal research, 2017, Volume: 62, Issue:1 Topics: Animals; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Hyperglycemia; M	2017
Melatonin as an Agent for Cardioprotection in Patients with ST-Elevation Myocardial Infarction and Short Ischaemic Time. Cardiovascular drugs and therapy, 2017, Volume: 31, Issue:2 Topics: Cardiovascular Diseases; Electrocardiography; Humans; Melatonin; Myocardial Infarction; Myocardial R	2017
Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling. Scientific reports, 2017, 01-25, Volume: 7 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cytochromes c; Cytosol; Diabe	2017
Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. Journal of pineal research, 2008, Volume: 45, Issue:4 Topics: Adrenergic Antagonists; Animals; Colforsin; Cyclic AMP; Guanylate Cyclase; Heart; Indoles; Isoproter	2008
Melatonin protects myocardium from ischemia-reperfusion injury in hypertensive rats: role of myeloperoxidase activity. Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:7 Topics: Animals; Blood Pressure; Enzyme Inhibitors; Glutathione; Hypertension; Lipid Peroxidation; Male; Mal	2008
The effect of high dose melatonin on cardiac ischemia- reperfusion Injury. Yonsei medical journal, 2008, Oct-31, Volume: 49, Issue:5 Topics: Animals; Antioxidants; Male; Malondialdehyde; Melatonin; Myocardial Reperfusion Injury; Peroxidase;	2008
Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. Journal of pineal research, 2009, Volume: 46, Issue:2 Topics: Animals; Antioxidants; Apoptosis; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Melatonin; Mi	2009
A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. Journal of pineal research, 2009, Volume: 46, Issue:2 Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrophysiologic Te	2009
Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? The heart surgery forum, 2009, Volume: 12, Issue:2 Topics: Circadian Rhythm; Coronary Artery Bypass; Female; Humans; Male; Melatonin; Metabolic Clearance Rate;	2009
Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:4 Topics: Animals; Antioxidants; Calcium; Cardiolipins; Cardiovascular Agents; Cyclosporine; Cytochromes c; He	2009
Role of melatonin in preventing mitochondrial dysfunction in myocardial ischemia-reperfusion injury. The American journal of cardiology, 2010, Nov-15, Volume: 106, Issue:10 Topics: Humans; Melatonin; Mitochondria; Myocardial Reperfusion Injury	2010
Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. Journal of pineal research, 2011, Volume: 50, Issue:2 Topics: Animals; Antioxidants; Male; Melatonin; Myocardial Reperfusion Injury; Obesity; Prediabetic State; R	2011
Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia. Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:3 Topics: Animals; Antioxidants; Arterial Pressure; Cyclic N-Oxides; Ethidium; Hypoxia; Male; Melatonin; Myoca	2013
Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. Journal of pineal research, 2002, Volume: 33, Issue:2 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemod	2002
Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. Journal of pineal research, 2002, Volume: 33, Issue:4 Topics: Animals; Antioxidants; Free Radical Scavengers; Male; Melatonin; Myocardial Infarction; Myocardial R	2002
Reactions of indole derivatives with cardioprotective activity with reactive oxygen species. Comparison with melatonin. Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:10 Topics: Animals; Antioxidants; Cardiotonic Agents; Free Radicals; Indoles; Melatonin; Myocardial Ischemia; M	2003
Cardioprotective effects of melatonin on recovery of rat donor hearts after 12-hour preservation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2003, Volume: 23, Issue:4 Topics: Animals; Cardiotonic Agents; Creatine Kinase; Free Radical Scavengers; Heart Transplantation; Humans	2003
Effects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in rats. Fundamental & clinical pharmacology, 2005, Volume: 19, Issue:3 Topics: Animals; Antioxidants; Atrophy; Blood Pressure; Caffeic Acids; Free Radicals; Male; Malondialdehyde;	2005
Short- and long-term effects of melatonin on myocardial post-ischemic recovery. Journal of pineal research, 2006, Volume: 40, Issue:1 Topics: Animals; Cardiotonic Agents; In Vitro Techniques; Male; Melatonin; Myocardial Contraction; Myocardia	2006
Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:2 Topics: Animals; Cardiolipins; Heart; Male; Melatonin; Mitochondria, Heart; Myocardial Reperfusion Injury; O	2006
[Melatonin recovers ischemic tolerance and decreases the sensitivity of mitochondrial permeability transition pore opening in the heart of aging rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2006, Volume: 52, Issue:3 Topics: Aging; Animals; bcl-2-Associated X Protein; Coronary Circulation; Free Radicals; Injections, Intrape	2006
Nitric oxide synthase inhibition in rats: melatonin reduces blood pressure and ischemia/reperfusion-induced infarct size. Scandinavian cardiovascular journal : SCJ, 2006, Volume: 40, Issue:4 Topics: Animals; Antioxidants; Blood Pressure; Hypertension; Male; Melatonin; Models, Animal; Myocardial Inf	2006
[Use of melatonin for cardiovascular diseases/Myocardial ischemia-reperfusion injury and melatonin]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2006, Volume: 6, Issue:3 Topics: Free Radical Scavengers; Humans; Melatonin; Myocardial Ischemia; Myocardial Reperfusion Injury	2006
Application of NMR-based metabonomics in the investigation of myocardial ischemia-reperfusion, ischemic preconditioning and antioxidant intervention in rabbits. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 30, Issue:3-4 Topics: Acetates; Alanine; Animals; Antioxidants; Blood Glucose; Discriminant Analysis; Indoles; Ischemic Pr	2007
Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats. Fertility and sterility, 2007, Volume: 88, Issue:1 Topics: Animals; Genitalia, Male; Male; Melatonin; Myocardial Ischemia; Myocardial Reperfusion Injury; Prote	2007
Effects of pharmacological concentration of melatonin on reperfusion injury in rats. Saudi medical journal, 2007, Volume: 28, Issue:9 Topics: Animals; Antioxidants; Melatonin; Myocardial Reperfusion Injury; Rats	2007
Investigating the protective effect of melatonin on liver injury related to myocardial ischemia-reperfusion. Medical science monitor : international medical journal of experimental and clinical research, 2007, Volume: 13, Issue:11 Topics: Animals; Antioxidants; Free Radical Scavengers; Glutathione; Liver; Male; Malondialdehyde; Melatonin	2007
Association of ischemia-modified albumin and melatonin in patients with ST-elevation myocardial infarction. Atherosclerosis, 2008, Volume: 199, Issue:1 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Circadian Rhythm; Electrocardiography; Female; Free Rad	2008
Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. Journal of pineal research, 2008, Volume: 45, Issue:4 Topics: Animals; Antioxidants; Blotting, Western; Calcium; Cardiomegaly; Cells, Cultured; Hematocrit; Homeos	2008
Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life sciences, 2000, Volume: 66, Issue:6 Topics: Animals; Male; Melatonin; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury;	2000
Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury. Life sciences, 2000, Volume: 67, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Free Radical Scavengers; Hydroxyl Radical; In Vitro Techniques; Lipid	2000
Amperometric ultramicrosensors for peroxynitrite detection and its application toward single myocardial cells. Analytical chemistry, 2000, Nov-01, Volume: 72, Issue:21 Topics: Animals; Animals, Newborn; Calibration; Cells, Cultured; Electrochemistry; Melatonin; Microchemistry	2000
Has melatonin a future as a cardioprotective agent? Cardiovascular drugs and therapy, 2001, Volume: 15, Issue:3 Topics: Animals; Antioxidants; Cardiotonic Agents; Cricetinae; Melatonin; Myocardial Reperfusion Injury; Rat	2001
Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovascular drugs and therapy, 2001, Volume: 15, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Free Radical Scavengers; Male; Melatonin; Myocardial Ischemia; Myocar	2001
Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? Journal of pineal research, 2002, Volume: 32, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Body Weight; Death, Sudden, Cardiac; Dose-Response Re	2002

melatonin and Injury, Myocardial Reperfusion