melatonin has been researched along with Injuries, Radiation in 40 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article reviews the usefulness of this indoleamine for specific aspects of breast cancer management, particularly in reference to melatonin's antiestrogenic and antioxidant properties: i) treatments oriented to breast cancer prevention, especially when the risk factors are obesity, steroid hormone treatment or chronodisruption by exposure to light at night (LAN); ii) treatment of the side effects associated with chemo- or radiotherapy." | 8.88 | Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation. ( Alonso-Gonzalez, C; Mediavilla, MD; Reiter, RJ; Sanchez-Barcelo, EJ, 2012) |
| "This article reviews the usefulness of this indoleamine for specific aspects of breast cancer management, particularly in reference to melatonin's antiestrogenic and antioxidant properties: i) treatments oriented to breast cancer prevention, especially when the risk factors are obesity, steroid hormone treatment or chronodisruption by exposure to light at night (LAN); ii) treatment of the side effects associated with chemo- or radiotherapy." | 4.88 | Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation. ( Alonso-Gonzalez, C; Mediavilla, MD; Reiter, RJ; Sanchez-Barcelo, EJ, 2012) |
| "The effects of melatonin and a related 5-methoxy-indole, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) were investigated in rats on the development of retinal degeneration in presence of high intensity illumination (HII)." | 3.67 | Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method. ( Aho, IM; Gynther, J; Kari, E; Leino, M; Markkanen, S, 1984) |
| "92." | 2.94 | Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial. ( Abdelrahman, H; Elsabagh, HH; Elsaka, RO; Mahmoud, SA; Moussa, E, 2020) |
| "Melatonin is a natural body product that has shown potent antioxidant property against various toxic agents." | 2.61 | Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure? ( Amini, P; Cheki, M; Farhood, B; Goushbolagh, NA; Mirtavoos-Mahyari, H; Motevaseli, E; Musa, AE; Najafi, M; Shabeeb, D; Shirazi, A; Yahyapour, R, 2019) |
| "It is estimated that more than half of cancer patients undergo radiotherapy during the course of their treatment." | 2.61 | Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization. ( Farhood, B; Goradel, NH; Khanlarkhani, N; Mirtavoos-Mahyari, H; Mortezaee, K; Motevaseli, E; Musa, AE; Najafi, M; Nashtaei, MS; Salehi, E; Shabeeb, D, 2019) |
| "Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy." | 2.55 | Melatonin as an anti-inflammatory agent in radiotherapy. ( Motevaseli, E; Najafi, M; Rezaeyan, AH; Rezapoor, S; Salajegheh, A; Shirazi, A, 2017) |
| " No severe adverse events were reported." | 2.48 | The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. ( Ai, F; Dong, TF; Duan, CH; Fu, QL; Jin, BZ; Lu, YZ; Wang, YM, 2012) |
| "The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses." | 2.41 | Apoptosis: biphasic dose responses. ( Calabrese, EJ, 2001) |
| "Melatonin (MLT) is a natural protector of neural cells against toxicity." | 1.46 | Radio-Protective Effects of Melatonin on Subventricular Zone in Irradiated Rat: Decrease in Apoptosis and Upregulation of Nestin. ( Malek, F; Moghahi, SMHN; Mokhtari, T; Naseri, S; Rastegar, T; Roghani, M; Shirazi, AR, 2017) |
| "The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group." | 1.40 | Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin. ( Aliasgharzadeh, A; Mahdavi, SR; Mihandoost, E; Shirazi, A, 2014) |
| "Pretreatment with melatonin also preserved villous height (p = 0." | 1.37 | Protective effects of melatonin and octreotide against radiation-induced intestinal injury. ( Bacanli, D; Kayaselcuk, F; Onal, C; Topkan, E; Yavuz, A; Yavuz, M, 2011) |
| "Melatonin (Mel) is a hormone synthesized mainly by the pineal gland." | 1.35 | [The protective role of melatonin in the course of UV exposure]. ( Cegielski, M; Dziegiel, P; Izykowska, I; Piotrowska, A; Podhorska-Okołów, M; Zabel, M, 2008) |
| "Melatonin is judged to be a potential protector against intestinal damage associated with radiotherapy." | 1.33 | Protective effects of melatonin on gamma-ray induced intestinal damage. ( Ando, K; Hino, M; Hirayama, R; Kojima, S; Monobe, M; Sumi, M; Uzawa, A, 2005) |
| "Melatonin is a free-radical scavenger and antioxidant." | 1.33 | Melatonin and roentgen irradiation of the testis. ( Abdelraheem, MH; Abou El-Ghait, AT; Abu-Dief, EE; Adly, MA; Hussein, MR, 2006) |
| "Melatonin is a hormone with multiple functions in humans, produced by the pineal gland and stimulated by beta-adrenergic receptors." | 1.31 | Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. ( Kim, BC; Kim, SP; Lee, KS; Ryoo, YW; Shon, BS, 2001) |
| "Melatonin is a hormone with multiple functions in humans, produced by the pineal gland and stimulated by beta-adrenergic receptors." | 1.31 | The effects of the melatonin on ultraviolet-B irradiated cultured dermal fibroblasts. ( Kim, BC; Lee, KS; Mun, KC; Ryoo, YW; Suh, SI, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 13 (32.50) | 29.6817 |
| 2010's | 17 (42.50) | 24.3611 |
| 2020's | 8 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirayama, J | 1 |
| Hattori, A | 1 |
| Takahashi, A | 1 |
| Furusawa, Y | 1 |
| Tabuchi, Y | 1 |
| Shibata, M | 1 |
| Nagamatsu, A | 1 |
| Yano, S | 1 |
| Maruyama, Y | 1 |
| Matsubara, H | 1 |
| Sekiguchi, T | 1 |
| Suzuki, N | 1 |
| Najafi, M | 6 |
| Cheki, M | 3 |
| Hassanzadeh, G | 1 |
| Amini, P | 3 |
| Shabeeb, D | 4 |
| Musa, AE | 4 |
| Elsabagh, HH | 1 |
| Moussa, E | 1 |
| Mahmoud, SA | 1 |
| Elsaka, RO | 1 |
| Abdelrahman, H | 1 |
| Ashrafizadeh, M | 1 |
| Motevaseli, E | 4 |
| Shirazi, A | 6 |
| El-Benhawy, SA | 1 |
| El-Tahan, RA | 1 |
| Nakhla, SF | 1 |
| Esmaely, F | 1 |
| Mahmoudzadeh, A | 1 |
| Chen, T | 1 |
| Luo, Y | 1 |
| Li, Q | 1 |
| Yang, C | 1 |
| Yuan, Y | 1 |
| Peng, J | 1 |
| Ban, M | 1 |
| Liang, Y | 1 |
| Zhang, W | 1 |
| Sheikholeslami, S | 1 |
| Aryafar, T | 1 |
| Abedi-Firouzjah, R | 1 |
| Banaei, A | 1 |
| Dorri-Giv, M | 1 |
| Zamani, H | 1 |
| Ataei, G | 1 |
| Majdaeen, M | 1 |
| Farhood, B | 3 |
| Naseri, S | 1 |
| Moghahi, SMHN | 1 |
| Mokhtari, T | 1 |
| Roghani, M | 1 |
| Shirazi, AR | 1 |
| Malek, F | 1 |
| Rastegar, T | 1 |
| Yılmaz, ES | 1 |
| Sapmaz, T | 1 |
| Kazgan, H | 1 |
| Yildiz, ŞM | 1 |
| Kocamaz, D | 1 |
| Akpolat, N | 1 |
| Sapmaz, E | 1 |
| Mirtavoos-Mahyari, H | 2 |
| Yahyapour, R | 1 |
| Goushbolagh, NA | 1 |
| Goradel, NH | 1 |
| Mortezaee, K | 1 |
| Khanlarkhani, N | 1 |
| Salehi, E | 1 |
| Nashtaei, MS | 1 |
| Abadi, SHMH | 1 |
| Alizadeh, AM | 1 |
| Changizi, V | 1 |
| Khalighfard, S | 1 |
| Nosrati, H | 1 |
| Mihandoost, E | 1 |
| Mahdavi, SR | 1 |
| Aliasgharzadeh, A | 1 |
| Karaaslan, C | 1 |
| Suzen, S | 1 |
| Karaer, I | 1 |
| Simsek, G | 1 |
| Gul, M | 1 |
| Bahar, L | 1 |
| Gürocak, S | 1 |
| Parlakpinar, H | 1 |
| Nuransoy, A | 1 |
| Zetner, D | 1 |
| Andersen, LP | 1 |
| Rosenberg, J | 1 |
| Rezaeyan, AH | 1 |
| Salajegheh, A | 1 |
| Rezapoor, S | 1 |
| Mainster, MA | 1 |
| Turner, PL | 1 |
| Onal, C | 1 |
| Kayaselcuk, F | 1 |
| Topkan, E | 1 |
| Yavuz, M | 1 |
| Bacanli, D | 1 |
| Yavuz, A | 1 |
| Das, B | 1 |
| Bennett, PV | 1 |
| Cutter, NC | 1 |
| Sutherland, JC | 1 |
| Sutherland, BM | 1 |
| Reiter, RJ | 3 |
| Tan, DX | 2 |
| Korkmaz, A | 1 |
| Manchester, LC | 1 |
| Wang, YM | 1 |
| Jin, BZ | 1 |
| Ai, F | 1 |
| Duan, CH | 1 |
| Lu, YZ | 1 |
| Dong, TF | 1 |
| Fu, QL | 1 |
| Sanchez-Barcelo, EJ | 1 |
| Mediavilla, MD | 1 |
| Alonso-Gonzalez, C | 1 |
| Kucuktulu, E | 1 |
| Gökcimen, A | 1 |
| Ozgüner, F | 1 |
| Karaöz, E | 1 |
| Ozen, S | 1 |
| Aydin, G | 1 |
| Herman, TS | 1 |
| Thomas, CR | 1 |
| Hussein, MR | 2 |
| Abu-Dief, EE | 2 |
| Abd El-Reheem, MH | 1 |
| Abd-Elrahman, A | 1 |
| Karslioglu, I | 1 |
| Ertekin, MV | 1 |
| Taysi, S | 1 |
| Koçer, I | 1 |
| Sezen, O | 1 |
| Gepdiremen, A | 1 |
| Koç, M | 1 |
| Bakan, N | 1 |
| Monobe, M | 1 |
| Hino, M | 1 |
| Sumi, M | 1 |
| Uzawa, A | 1 |
| Hirayama, R | 1 |
| Ando, K | 1 |
| Kojima, S | 1 |
| Sisodia, R | 1 |
| Kumari, S | 1 |
| Verma, RK | 1 |
| Bhatia, AL | 1 |
| Abou El-Ghait, AT | 1 |
| Adly, MA | 1 |
| Abdelraheem, MH | 1 |
| Marozik, P | 1 |
| Mothersill, C | 1 |
| Seymour, CB | 1 |
| Mosse, I | 1 |
| Melnov, S | 1 |
| Izykowska, I | 1 |
| Piotrowska, A | 1 |
| Podhorska-Okołów, M | 1 |
| Cegielski, M | 1 |
| Zabel, M | 1 |
| Dziegiel, P | 1 |
| Leino, M | 1 |
| Aho, IM | 1 |
| Kari, E | 1 |
| Gynther, J | 1 |
| Markkanen, S | 1 |
| Dreher, F | 1 |
| Gabard, B | 1 |
| Schwindt, DA | 1 |
| Maibach, HI | 1 |
| Kim, BC | 2 |
| Shon, BS | 1 |
| Ryoo, YW | 2 |
| Kim, SP | 1 |
| Lee, KS | 2 |
| Calabrese, EJ | 1 |
| Suh, SI | 1 |
| Mun, KC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis[NCT03833570] | Phase 2 | 40 participants (Actual) | Interventional | 2018-01-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for melatonin and Injuries, Radiation
| Article | Year |
|---|---|
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure.
Topics: Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Humans; Melatonin; Radiation Injuries; | 2023 |
The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.
Topics: Animals; Humans; Lung; Lung Neoplasms; Melatonin; Pneumonia; Pulmonary Fibrosis; Radiation Injuries; | 2021 |
Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?
Topics: Animals; Antioxidants; DNA Repair Enzymes; Humans; Melatonin; Mitochondria; NADPH Oxidases; Radiatio | 2019 |
Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization.
Topics: Animals; Antioxidants; Humans; Melatonin; Neoplasms; Radiation Injuries; Radiation Tolerance; Radiat | 2019 |
Radiation-Induced Heart Diseases: Protective Effects of Natural Products.
Topics: Biological Products; Caffeic Acids; Curcumin; Drug Combinations; Drugs, Chinese Herbal; Guaiacol; He | 2019 |
Antioxidant properties of melatonin and its potential action in diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Clinical Trials as Topic; Diabetes Mellitus; Humans | 2015 |
Melatonin as Protection Against Radiation Injury: A Systematic Review.
Topics: Animals; Antioxidants; Melatonin; Radiation Injuries | 2016 |
Melatonin as an anti-inflammatory agent in radiotherapy.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Humans; Inflammation; Melatonin; Mucositis; Neoplasms | 2017 |
The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials.
Topics: Antineoplastic Agents; Antioxidants; Combined Modality Therapy; Humans; Melatonin; Neoplasms; Radiat | 2012 |
Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation.
Topics: Animals; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Estrogen Antagonists; Female; Humans | 2012 |
Melatonin as a radioprotective agent: a review.
Topics: Animals; Antioxidants; DNA; DNA Damage; Free Radical Scavengers; Humans; Melatonin; Mice; Radiation | 2004 |
Apoptosis: biphasic dose responses.
Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relation | 2001 |
3 trials available for melatonin and Injuries, Radiation
| Article | Year |
|---|---|
Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial.
Topics: Antioxidants; Head and Neck Neoplasms; Humans; Melatonin; Radiation Injuries; Saliva; Stomatitis | 2020 |
The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology.
Topics: Administration, Oral; Adult; Carcinogenesis; DNA Breaks, Double-Stranded; Healthy Volunteers; Histon | 2020 |
Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo.
Topics: Administration, Cutaneous; Adult; Antioxidants; Ascorbic Acid; Double-Blind Method; Drug Therapy, Co | 1998 |
25 other studies available for melatonin and Injuries, Radiation
| Article | Year |
|---|---|
Protection from Radiation-induced Damage in Rat's Ileum and Colon by Combined Regimens of Melatonin and Metformin: A Histopathological Study.
Topics: Animals; Colon; Drug Therapy, Combination; Enteritis; Humans; Ileum; Male; Melatonin; Metformin; Mod | 2020 |
Mitigation of radiation-induced hematopoietic system injury by melatonin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Male; Melatonin; Mice; Mice, Inbred C57BL; Radiation Injuri | 2020 |
Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers.
Topics: Adult; Antioxidants; Biomarkers; Case-Control Studies; Egypt; Female; Humans; Hydrocortisone; Inflam | 2021 |
Melatonin reduces radiation damage in inner ear.
Topics: Animals; Auditory Threshold; Ear, Inner; Evoked Potentials, Auditory, Brain Stem; Gene Expression Re | 2021 |
Radio-Protective Effects of Melatonin on Subventricular Zone in Irradiated Rat: Decrease in Apoptosis and Upregulation of Nestin.
Topics: Animals; Apoptosis; Lateral Ventricles; Male; Melatonin; Nestin; Radiation Injuries; Radiation-Prote | 2017 |
Examination of the antioxidant effects of pre-HSG melatonin use on ovarian surface epithelium in rats: An experimental study.
Topics: Animals; Antioxidants; Contrast Media; Epithelium; Ethiodized Oil; Female; Hysterosalpingography; Me | 2018 |
The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer.
Topics: Animals; Antioxidants; Colonic Neoplasms; Glutathione Peroxidase; Heart; Humans; Lung; Male; Malondi | 2018 |
Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Caspase 3; Catalase; Gamma Rays; Gene Expression; Glu | 2014 |
Melatonin protects inner ear against radiation damage in rats.
Topics: Animals; Ear, Inner; Male; Melatonin; Radiation Injuries; Radiotherapy; Random Allocation; Rats; Rat | 2015 |
Article on intraocular lenses (IOLs).
Topics: Eye Injuries; Humans; Lenses, Intraocular; Melatonin; Photoreceptor Cells, Vertebrate; Prosthesis De | 2009 |
Protective effects of melatonin and octreotide against radiation-induced intestinal injury.
Topics: Animals; Intestinal Diseases; Male; Melatonin; Mice; Octreotide; Radiation Injuries; Radiation-Prote | 2011 |
Melatonin protects human cells from clustered DNA damages, killing and acquisition of soft agar growth induced by X-rays or 970 MeV/n Fe ions.
Topics: Agar; Cell Proliferation; Cell Survival; DNA; DNA Damage; DNA, Superhelical; Energy Transfer; Escher | 2011 |
The disaster in Japan: utility of melatonin in providing protection against ionizing radiation.
Topics: Humans; Japan; Melatonin; Radiation Injuries; Radiation, Ionizing | 2011 |
Protective effect of melatonin against radiation induced nephrotoxicity in rats.
Topics: Animals; Antioxidants; Gamma Rays; Male; Melatonin; Nephrosclerosis; Radiation Injuries; Radiation-P | 2012 |
The effect of melatonin on morphological changes in liver induced by magnetic field exposure in rats.
Topics: Animals; Electromagnetic Fields; Injections, Intraperitoneal; Liver; Male; Melatonin; Radiation; Rad | 2002 |
Ultrastructural evaluation of the radioprotective effects of melatonin against X-ray-induced skin damage in Albino rats.
Topics: Albinism; Animals; Melatonin; Microscopy, Electron; Radiation Injuries; Radiation-Protective Agents; | 2005 |
Radioprotective effects of melatonin on radiation-induced cataract.
Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Female; Free Radical Scavengers; Heavy Ions | 2005 |
Protective effects of melatonin on gamma-ray induced intestinal damage.
Topics: Animals; Gamma Rays; Jejunum; Male; Melatonin; Mice; Mice, Inbred ICR; Radiation Injuries; Radiation | 2005 |
Prophylactic role of melatonin against radiation induced damage in mouse cerebellum with special reference to Purkinje cells.
Topics: Animals; Brain Injuries; Cell Survival; Cells, Cultured; Cerebellum; Male; Melatonin; Mice; Purkinje | 2006 |
Melatonin and roentgen irradiation of the testis.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Radiation; Male; Melatonin; Radiation Injuries | 2006 |
Bystander effects induced by serum from survivors of the Chernobyl accident.
Topics: Bystander Effect; Cell Line, Transformed; Cell Survival; Chernobyl Nuclear Accident; Free Radical Sc | 2007 |
[The protective role of melatonin in the course of UV exposure].
Topics: Animals; Humans; Keratinocytes; Melatonin; Pineal Gland; Radiation Injuries; Radiation-Protective Ag | 2008 |
Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method.
Topics: Animals; Anticonvulsants; Carbolines; Indoles; Light; Male; Melatonin; Radiation Injuries; Rats; Rat | 1984 |
Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts.
Topics: Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; Fibroblasts; Fl | 2001 |
The effects of the melatonin on ultraviolet-B irradiated cultured dermal fibroblasts.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Child, Preschool; DNA; Fibroblasts; Flow Cytometry; Free | 2001 |