melatonin has been researched along with Inflammation in 376 studies
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aimed to investigate the effects of propolis and melatonin supplementation on inflammation, clinical outcomes, and oxidative stress markers in patients with primary pneumosepsis." | 9.51 | Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial. ( Abdelbasset, WK; Alkadir, OKA; Bagheri Moghaddam, A; Beigmohammadi, MT; Fathi Najafi, M; Firouzi, S; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Malekahmadi, M; Mir, M; Pahlavani, N; Ranjbar, G; Rostami, A; Sadeghi, O; Safarian, M; Sahebkar, A; Sedaghat, A; Tabesh, H; Taifi, A, 2022) |
| "In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks." | 9.41 | The Effect of Melatonin on Periodontitis. ( Bábíčková, J; Baňasová, L; Celec, P; Chobodová, P; Janko, J; Konečná, B; Tóthová, Ľ, 2021) |
| "We describe the protocol for a clinical trial design evaluating the effects of simultaneous administration of propolis and melatonin in patients with primary sepsis." | 9.30 | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. ( Bagheri Moghaddam, A; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Jarahi, L; Mazloumi Kiapey, SS; Nematy, M; Norouzy, A; Pahlavani, N; Reazvani, R; Safarian, M; Sedaghat, A, 2019) |
| " The tight connection between adipose tissue and the immune system has been demonstrated to play a crucial role in inflammation, and melatonin is important for circadian rhythm regulation and metabolic homeostasis, in which it orchestrates several molecular mechanisms involved in obesity and associated inflammation." | 9.22 | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review. ( Amatrudo, F; Colao, A; Graziadio, C; Liccardi, A; Montò, T; Muscogiuri, G; Negri, M; Patalano, R; Pivonello, C; Pivonello, R, 2022) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 9.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity." | 9.01 | Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. ( Hardeland, R, 2019) |
| " A wide array of biochemical processes underlie MDD presentations and their shift to a recurrent, neuroprogressive course, including: increased immune-inflammation, tryptophan catabolites (TRYCATs), mitochondrial dysfunction, aryl hydrocarbonn receptor activation, and oxidative and nitrosative stress (O&NS), as well as decreased sirtuins and melatonergic pathway activity." | 8.98 | Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. ( Anderson, G, 2018) |
| "Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent." | 8.98 | Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension. ( Diez, ER; Ferder, L; Manucha, W; Prado, NJ, 2018) |
| "This systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to determine the effect of melatonin supplementation on the inflammatory markers among individuals with metabolic syndrome (MetS) and related disorders." | 8.98 | The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials. ( Akbari, M; Amirani, E; Asemi, Z; Heydari, ST; Lankarani, KB; Ostadmohammadi, V; Reiter, RJ; Tabrizi, R, 2018) |
| " Since there is a direct relationship between chronic inflammation and many emerging disorders like cancer, oral diseases, kidney diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of this review is to describe the use and role of melatonin, a hormone secreted by the pineal gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant." | 8.91 | Evaluating the Oxidative Stress in Inflammation: Role of Melatonin. ( Calpena, AC; Clares, B; Sánchez, A, 2015) |
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 8.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "Electrochemical arrays were used to measure the overflow of serotonin (5-HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical-induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function." | 8.31 | Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation. ( Kotecha, N; Lavoie, B; Mawe, GM; Patel, BA; Perez, F, 2023) |
| "To investigate, in the liver of adult offspring, the possible effects of melatonin supplementation in the obese mother during pregnancy and lactation." | 8.31 | Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress. ( Aguila, MB; Ajackson, M; Mandarim-de-Lacerda, CA; Marcondes-de-Castro, IA; Nagagata, BA, 2023) |
| " Although several pharmacological interventions, including melatonin and metformin, have been reported to protect against various cardiovascular diseases, their potential roles in trastuzumab-induced cardiotoxicity remain elusive." | 8.31 | Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Nawara, W; Prathumsap, N; Shinlapawittayatorn, K, 2023) |
| "In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model." | 8.31 | Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway. ( Ateş, Ş; Doğanyiğit, Z; Oflamaz, AO; Söylemez, ESA; Uçar, S; Yilmaz, S, 2023) |
| "This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic acid (vitamin C, ASA) in treating sepsis-induced lung injury in rats." | 8.31 | Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study. ( Çiçek, B; Demir, Ö; Huyut, MT; Tavacı, T; Üstündağ, H; Yüce, N, 2023) |
| "This study suggests that maternal melatonin supplementation can shape the gut microbiota and metabolism of offspring under normal physiological conditions and protect them against LPS-induced inflammation in early life." | 8.31 | Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life. ( Cai, Y; Feng, Z; Hao, H; Ke, Q; Lai, J; Li, F; Li, S; Liu, X; Lu, Z; Ma, F; Xiao, X, 2023) |
| "To investigate the combined therapeutic potential of melatonin and ascorbic acid in mitigating sepsis-induced heart and kidney injury in male rats and assess the combination therapy's effects on inflammation, cellular damage, oxidative stress, and vascular function-related markers." | 8.31 | A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats. ( Akbaba, Ö; Demir, Ö; Doğanay, S; Huyut, MT; Kalındemirtaş, FD; Kurt, N; Özgeriş, FB; Üstündağ, H, 2023) |
| "In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process." | 8.31 | Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus). ( Gao, WT; Liu, JX; Sun, HJ; Wang, DH; Zhang, XY, 2023) |
| "Melatonin confers protection against myocardial injury by reducing inflammation and inhibiting apoptosis." | 8.31 | Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis. ( Huo, JL; Liu, ZH; Ren, K; Wu, F, 2023) |
| "The aim of this study was to investigate the effects of melatonin on the serum asymmetric dimethylarginine (ADMA) levels and the expressions of vaspin, visfatin, dimethylarginine dimethylaminohydrolase (DDAH), and signal transducer and activator of transcription-3 (STAT-3) for evaluation of endothelial function and inflammation in the hypercholesterolemic rats." | 8.31 | The effects of melatonin against atherosclerosis-induced endothelial dysfunction and inflammation in hypercholesterolemic rats. ( Aslan, G; İlhan, N; Sahin, K; Sahna, E; Sezgin, D; Tuzcu, M, 2023) |
| "Melatonin may inhibit inflammation and associated oxidative stress on the surface of knee cartilage." | 8.12 | Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage. ( Ke, C; Li, H; Wang, J; Wang, L; Xu, J; Yang, D; Ying, H; Zhu, H, 2022) |
| "Melatonin limited the negative effects associated with alcohol consumption and low-intensity inflammation." | 8.02 | Melatonin maintains the function of the blood redox system at combined ethanol-induced toxicity and subclinical inflammation in mice. ( Kurhaluk, N; Lukash, O; Tkachenko, H; Winklewski, PJ; Wszedybyl-Winklewska, M, 2021) |
| "Melatonin (MEL) shows an anti-inflammatory effect and regulates intestinal microbiota communities in animals and humans; Ochratoxin A (OTA) induces liver inflammation through intestinal microbiota." | 8.02 | Melatonin alleviates Ochratoxin A-induced liver inflammation involved intestinal microbiota homeostasis and microbiota-independent manner. ( Chen, J; Fu, Y; Huang, L; Jiang, X; Li, Y; Ma, W; Meca, G; Wang, H; Wang, S; Wang, W; Xia, D; Yang, L; Ye, H; Zhai, S; Zhang, X; Zhu, S; Zhu, Y, 2021) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 8.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 8.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation." | 8.02 | A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement. ( Alizadeh, Z; Dashti-Khavidaki, S; Ghaderkhani, S; Keyhanian, N; Pourpak, Z; Shokouhi Shoormasti, R, 2021) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 7.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| " To address this, we investigated the effect of melatonin on ischemia-induced fibrosis." | 7.96 | Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020) |
| " Melatonin is a strong anti-inflammatory hormone, mediating the cytoprotective effect of a variety of retinal cells against hyperglycemia." | 7.96 | Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. ( Chen, L; Liu, W; Liu, X; Shi, Q; Song, E; Sun, Y; Tu, Y; Wang, K; Wang, X; Wang, Z; Zhao, Q; Zhu, M, 2020) |
| "We have previously shown an inverse correlation between testicular melatonin concentration and inflammation/oxidative stress-related markers levels in infertile men showing unexplained azoospermia." | 7.96 | Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology. ( Calandra, RS; Frungieri, MB; Levalle, O; Martinez, G; Matzkin, ME; Muñoz de Toro, MM; Ponzio, R; Puigdomenech, E; Riviere, E; Rossi, SP; Tavalieri, YE; Terradas, C, 2020) |
| "Inflammation is associated with injury to immature lungs, and melatonin administration to preterm newborns with acute respiratory distress improves pulmonary outcomes." | 7.96 | Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation. ( Burd, I; Chudnovets, A; Kang, Y; Lee, JY; Lei, J; Na, Q; Shin, HE; Shin, NE; Song, H, 2020) |
| " This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury." | 7.96 | Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. ( Chao, LM; Guo, A; Guo, SN; Li, Y; Liu, C; Lv, WJ; Qu, Q; Tang, XG; Wei, GW; Xiong, Y; Yin, YL; Yu, LZ; Zhou, JH, 2020) |
| "Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism has not been identified." | 7.96 | Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury. ( Cui, JW; Ma, X; Wei, LL; Yang, B; Zang, LE; Zhang, MY, 2020) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 7.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| "Both CpG oligodeoxynucleotide (CpG-ODN) and melatonin have been reported to induce Th1 response and contribute to allergic asthma resistance." | 7.91 | Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome. ( Fan, XY; Fei, GH; Wu, HM; Xie, QM; Xu, J; Zhao, CC, 2019) |
| " N-acetyl-5-methoxytryptamine (melatonin) is a natural hormone secreted by the pineal gland which has been shown to participate in several physiological and pathological progresses, such as aging, anti-inflammation, anti-apoptosis and autophagy regulation." | 7.91 | Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. ( Chen, Z; Han, Y; He, F; Qian, L; Su, Q; Tan, J; Yan, M; Zhang, Q; Zhang, Y, 2019) |
| "The anti-catabolic bisphosphonate alendronate is considered as the first-line medical treatment in post-menopausal osteoporosis; but several side effects, including gastric mucosal injury, are associated with its use." | 7.91 | Melatonin supports alendronate in preserving bone matrix and prevents gastric inflammation in ovariectomized rats. ( Akkiprik, M; Çilingir-Kaya, ÖT; Ercan, F; Gürler, EB; Peker Eyüboglu, I; Reiter, RJ; Yegen, BÇ, 2019) |
| "Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury." | 7.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| " The aim of the present study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of antibiotics and/or melatonin treatments on diet-induced hepato-intestinal dysfunction and inflammation." | 7.91 | The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats. ( Akdeniz, E; Aksu, B; Arabacı Tamer, S; Bagriacik, F; Cayirli, YB; Çetinel, Ş; Cilingir Kaya, ÖT; Kahraman, MM; Onur, ND; Sahin, D; Yeğen, BÇ; Yildirim, A; Yuksel, M, 2019) |
| "To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis." | 7.88 | Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018) |
| "This study demonstrated that melatonin pretreatment attenuated lung ischaemia-reperfusion injury via inhibition of oxidative stress, inflammation and apoptosis." | 7.88 | Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. ( Wang, JJ; Wang, JS; Wang, ML; Wang, WD; Wei, CH; Zhang, J, 2018) |
| "Melatonin may protect against HS-induced myocardial injury in male rats by mitigating oxidative stress and inflammation." | 7.88 | Melatonin provides protection against heat stroke-induced myocardial injury in male rats. ( Chang, CP; Chao, CM; Lin, CH; Lin, MT; Lin, S; Lin, X; Liu, L; Wen, S; Ye, Z; Zhao, T; Zuo, D, 2018) |
| " Melatonin can improve peripheral nerve recovery by inhibiting oxidative stress and inflammation after traumatic insults." | 7.88 | 3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration. ( Cheng, Y; Fan, C; Fang, Z; Han, Q; Ouyang, Y; Qian, Y; Song, J; Yuan, WE; Zhao, X, 2018) |
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 7.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| "Increased levels of AANAT, melatonin, and MT1 in the inflamed oral mucosal tissue of OLP patients imply that chronic inflammation may induce the local biosynthesis of melatonin via AANAT, and may enhance the action of melatonin via MT1." | 7.85 | Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation. ( Chaiyarit, P; Hormdee, D; Klanrit, P; Luengtrakoon, K; Noisombut, R; Vichitrananda, V; Wannakasemsuk, W, 2017) |
| "Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood." | 7.83 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. ( Chao, H; Hou, L; Ji, J; Li, Z; Lin, C; Liu, N; Liu, Y; Xu, X, 2016) |
| "To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation." | 7.83 | Melatonin modulates adiponectin expression on murine colitis with sleep deprivation. ( Baik, HW; Choi, JW; Chung, SH; Gye, MC; Jun, JH; Kim, EK; Kim, JB; Kim, SH; Kim, TK; Lim, JY; Park, YS; Sull, JW; Sung, HJ, 2016) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 7.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| "In this study, the relationship between the plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several intercellular interactions including inflammatory and immune responses, and early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined." | 7.81 | The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery. ( Akçalı, A; Ali Elçi, M; Deniz, H; Geyik, S; Hafız, E; Murat Geyik, A; Yiğiter, R, 2015) |
| "The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats." | 7.80 | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats. ( Cano Barquilla, P; Cardinali, DP; Esquifino, AI; Fernández-Mateos, P; Jiménez-Ortega, V; Pagano, ES, 2014) |
| "The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi." | 7.80 | Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. ( Kireev, RA; Tresguerres, JA; Vara, E; Viña, J, 2014) |
| " We tested the hypothesis that melatonin ameliorates the CIH-induced lipid peroxidation, local inflammation and cellular injury in rat adrenal medulla." | 7.80 | Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla. ( Fung, ML; Liu, Y; Tipoe, GL, 2014) |
| "We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats." | 7.79 | Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013) |
| "Thirty rats were divided into five groups: a control group, an acetic acid-induced colitis group, a group treated with melatonin before colitis induction, a group treated short-term after colitis induction, and a group treated long-term after colitis induction." | 7.79 | The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. ( Blann, A; El Sers, DA; Idriss, NK; Jaumdally, RJ; Sayyed, HG, 2013) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 7.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model." | 7.79 | Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway. ( Chen, G; Ji, C; Wang, Z; Wu, L; You, W, 2013) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 7.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "The aim of this study was to investigate the effects of melatonin on low-grade inflammation and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 7.79 | Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. ( Adem, A; Agil, A; Fernández-Vázquez, G; Ibán-Arias, R; Jiménez-Aranda, A; Marchal, JA; Navarro-Alarcón, M; Reiter, RJ, 2013) |
| "Human endothelial cells were treated with lipopolysaccharide (LPS) plus peptidoglycan G (PepG) to simulate sepsis, in the presence of melatonin, 6-hydroxymelatonin, tryptamine, or indole-3-carboxylic acid." | 7.77 | Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. ( Almawash, AM; Galley, HF; Lowes, DA; Reid, VL; Webster, NR, 2011) |
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 7.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "Our aim was to determine 24-hour patterns of serum melatonin and their relationship to overnight decline in physiology in subjects with nocturnal asthma, non-nocturnal asthma, and in healthy controls." | 7.72 | Elevated serum melatonin is associated with the nocturnal worsening of asthma. ( Ellison, MC; Kraft, M; Martin, RJ; Sutherland, ER, 2003) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 7.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "The aim of the present study was to investigate the effect of melatonin on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role." | 7.70 | Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. ( Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E, 1999) |
| "Melatonin is a natural molecule present throughout both the plant and animal kingdoms." | 7.01 | Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective. ( Asemi, R; Asemi, Z; Badehnoosh, B; Rajabpoor Nikoo, N; Reiter, RJ; Shafabakhsh, R; Sharifi, M, 2023) |
| "Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies." | 6.82 | Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved. ( Chuffa, LGA; Manucha, W; Martín Giménez, VM; Reiter, RJ; Simão, VA, 2022) |
| "Melatonin is a neuroendocrine hormone that is synthesized and released primarily at night from the mammalian pineal gland." | 6.82 | Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight. ( Chung, JP; Fang, L; Hung, SW; Li, Y; Man, GC; Wang, CC; Zhang, R; Zhang, T, 2022) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 6.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| "Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it." | 6.72 | Ischemic stroke, obesity, and the anti-inflammatory role of melatonin. ( Govitrapong, P; Tocharus, C; Tocharus, J; Yawoot, N, 2021) |
| "Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few." | 6.72 | Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021) |
| " Breast cancer risk factors include smoking, alcohol consumption, personal and family history, hypertension, and hormone therapy, long-term use of nonsteroidal anti-inflammatory drugs and tobacco usage." | 6.61 | Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms. ( Amin, N; Asemi, Z; Reiter, RJ; Shafabakhsh, R, 2019) |
| "Melatonin (MLT) is an amine hormone secreted mainly by the pineal gland." | 6.61 | [Advances in the role of melatonin in infectious diseases: A review]. ( Jin, B; Ma, Y; Tang, K; Zhang, C; Zhang, Y, 2019) |
| "Melatonin also acts as a cell survival agent by modulating autophagy in various cell types and under different conditions through amelioration of oxidative stress, ER stress and inflammation." | 6.58 | Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress. ( Dehdashtian, E; Ghaznavi, H; Hosseinzadeh, A; Mehrzadi, S; Naseripour, M; Reiter, RJ; Safa, M; Yousefi, B, 2018) |
| "Melatonin is an immune modulator that displays both pro- and anti-inflammatory properties." | 6.58 | Melatonin and inflammation-Story of a double-edged blade. ( Hardeland, R, 2018) |
| "5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model." | 6.50 | 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014) |
| "Treatment with melatonin is useful in a diverse range of medical conditions, including bipolar disorder, Alzheimer's disease, depression and fibromyalgia." | 6.50 | Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders. ( Anderson, G; Maes, M, 2014) |
| "Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis." | 6.49 | Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. ( Chang, DM; Chen, SJ; Huang, SH; Lin, GJ; Sytwu, HK; Wang, CH, 2013) |
| "Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions." | 6.46 | Melatonin: a pleiotropic molecule regulating inflammation. ( Diederich, M; Ghibelli, L; Radogna, F, 2010) |
| "Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence." | 6.42 | Retardation of brain aging by chronic treatment with melatonin. ( Bondy, SC; Campbell, A; Lahiri, DK; Perreau, VM; Sharman, EH; Sharman, KZ; Zhou, J, 2004) |
| "Melatonin has been shown to possess anti-inflammatory effects, among a number of actions." | 6.41 | Melatonin and its relation to the immune system and inflammation. ( Calvo, JR; Karbownik, M; Qi, W; Reiter, RJ; Tan, DX, 2000) |
| "Treatment with melatonin has been shown to prevent in vivo the delayed vascular decompensation and the cellular energetic failure associated with shock, inflammation and ischemia/reperfusion injury." | 6.41 | Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. ( Cuzzocrea, S; Reiter, RJ, 2001) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 6.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 5.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Obesity is well-established as a common comorbidity in ischemic stroke." | 5.91 | Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats. ( Govitrapong, P; Sengking, J; Tocharus, C; Tocharus, J; Yawoot, N, 2023) |
| "Periodontitis is a chronic infectious disease caused by bacterial irritation." | 5.91 | Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy. ( Cui, Y; He, X; Hong, S; Hu, X; Li, X; Li, Y; Lin, K; Mao, L; Wang, X; Xia, Y, 2023) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 5.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Melatonin (Mel) has been reported for the protection against liver injury." | 5.91 | Melatonin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat's liver from the hazardous effects of CCL4. ( Farid, A; Michael, V; Safwat, G, 2023) |
| "Melatonin plays a protective role against Aβ-induced inflammation via an inflammasome-associated mechanism that is essential in inducing the active forms of cytokines and pyroptosis." | 5.91 | The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines. ( Boontor, A; Govitrapong, P; Kutpruek, S; Nopparat, C, 2023) |
| "Melatonin (MLT) is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage." | 5.72 | Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis. ( Altinoz, E; Ballur, AFH; Bicer, Y; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yigitturk, G, 2022) |
| "Melatonin was administered at 20 mg/kg during the last 2 weeks." | 5.72 | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. ( Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG, 2022) |
| "Melatonin treatment or its co-administration with HRT upregulated the expressions of IL-10 and SIRT1, reduced the expressions of IL-6 and TNF-α, and reduced DNA damage in the hearts and thoracic aortae of non-exercised rats." | 5.72 | Melatonin Alleviates Ovariectomy-Induced Cardiovascular Inflammation in Sedentary or Exercised Rats by Upregulating SIRT1. ( Altınoluk, T; Arabacı Tamer, S; Baykal, Z; Çevik, Ö; Dur, ZS; Emran, M; Ercan, F; Korkmaz, S; Levent, HN; Ural, MA; Yeğen, BÇ; Yıldırım, A; Yüksel, M; Yüksel, RG, 2022) |
| "Melatonin has known anti-inflammatory effects." | 5.72 | Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. ( Duan, H; Ge, W; Hu, J; Li, J; Zeng, J; Zhao, X, 2022) |
| "pneumoniae-induced inflammation is necessary for the survival of patients." | 5.72 | Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase. ( Jiang, W; Liu, J; Yang, W; Zhao, X, 2022) |
| "In melatonin-treated fishes, significant amelioration of oxidative stress was observed with reduced levels of MDA and pro-inflammatory cytokines." | 5.72 | Melatonin ameliorates lipopolysaccharide induced brain inflammation through modulation of oxidative status and diminution of cytokine rush in Danio rerio. ( Chakraborty, SB; Maiti, AK; Moniruzzaman, M; Saha, I; Saha, NC, 2022) |
| " Chronic use of METH is associated with cognitive impairments in both human and animal studies, but the underlying mechanism remains unclear." | 5.62 | Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus. ( Chancharoen, P; Govitrapong, P; Lwin, T; Mukda, S; Ngampramuan, S; Pinyomahakul, J; Veschsanit, N; Viwatpinyo, K; Yang, JL, 2021) |
| "Melatonin was administered i." | 5.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Sarcopenia is one of the most common features of cirrhosis, contributing to morbidity and mortality in this population." | 5.62 | Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise. ( Colares, JR; da Fonseca, SRB; Dias, AS; Lehmann, M; Marroni, CA; Marroni, NAP; Martins, GDS; Miguel, FM; Picada, JN; Rosa, CGS, 2021) |
| "Melatonin has been confirmed to be useful in various diseases, including Alzheimer's disease, liver injuries and diseases, and cancers, while its role in IBDs remains unclear." | 5.62 | Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants. ( Yuan, XQ; Zhang, XM, 2021) |
| "Mice treated with Luzindole, LPS, and Luzindole+LPS showed villus height shortening." | 5.62 | Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice. ( Bruin, PFC; Bruin, VMS; Duarte, ASG; Matos, RS; Oriá, RB; Pinto, DV; Santos, FA; Viana, AFSC, 2021) |
| "Melatonin treatment significantly abolished the effects of LPS, as demonstrated by improved depressive-like behaviors, normalized autophagy-related gene expression, and reduced levels of cytokines." | 5.56 | Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation. ( Ali Shah, F; Ali, T; Hao, Q; Li, S; Li, W; Liu, G; Liu, Z; Murtaza, I; Rahman, SU; Yang, X; Zhang, Z, 2020) |
| "The present study aimed to investigate the effects of propolis and melatonin supplementation on inflammation, clinical outcomes, and oxidative stress markers in patients with primary pneumosepsis." | 5.51 | Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial. ( Abdelbasset, WK; Alkadir, OKA; Bagheri Moghaddam, A; Beigmohammadi, MT; Fathi Najafi, M; Firouzi, S; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Malekahmadi, M; Mir, M; Pahlavani, N; Ranjbar, G; Rostami, A; Sadeghi, O; Safarian, M; Sahebkar, A; Sedaghat, A; Tabesh, H; Taifi, A, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD) is the hepatic side of the metabolic syndrome." | 5.51 | Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. ( De Petro, G; García-Gómez, R; Grossi, I; Lavazza, A; Monsalve, M; Patel, GA; Rezzani, R; Salvi, A; Stacchiotti, A, 2019) |
| "Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties." | 5.51 | Melatonin improves the structure and function of autografted mice ovaries through reducing inflammation: A stereological and biochemical analysis. ( Noori Hassanvand, M; Shojafar, E; Soleimani Mehranjani, M, 2019) |
| "Melatonin has been shown to reduce oxidative stress and mitigate hypercoagulability." | 5.51 | Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model. ( Burd, I; Dong, J; Jia, B; Jones-Beatty, K; Lee, JY; Lei, J; Li, S; McLane, MW; Na, Q; Ozen, M; Shin, NE, 2019) |
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 5.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease." | 5.48 | Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 5.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "Systemic inflammation is known to impair the microcirculation in intestine and other organs as a result of multifactorial events." | 5.46 | Melatonin reduces changes to small intestinal microvasculature during systemic inflammation. ( de Groot, H; Effenberger-Neidnicht, K; Lansink, MO; Patyk, V, 2017) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 5.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 5.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| "Melatonin has been shown to have anti-inflammatory and anti-allodynia effects in both preclinical and clinical studies." | 5.46 | Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain. ( Cui, W; Li, LB; Li, YY; Tian, BP; Wang, YS; Zhang, GS; Zhang, ZC, 2017) |
| "Melatonin (MLT) has been reported with an effective antioxidant activity." | 5.46 | Protective effect of melatonin on the development of abdominal aortic aneurysm in a rat model. ( Cong, Z; Hao, S; Huang, H; Jing, H; Li, K; Li, P; Shen, Y; Tang, L, 2017) |
| "Excess weight and obesity are severe public health threats worldwide." | 5.46 | Melatonin prevents obesity through modulation of gut microbiota in mice. ( Hong, F; Jia, L; Jin, X; Wang, J; Wang, S; Xu, P; Xue, T; Zhai, Y, 2017) |
| "Colitis was induced by intracolonic (i." | 5.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Melatonin (5 mg/kg) was administered i." | 5.43 | Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Chalon, S; Favrais, G; Gressens, P; Longini, M; Saliba, E, 2016) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 5.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Melatonin was administrated intraperitoneally (30 mg/kg)." | 5.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Melatonin is a strong antioxidant that has beneficial effects against SAH in rats, including reduced mortality and reduced neurological deficits." | 5.42 | Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. ( Cao, S; Chen, G; Chen, J; Duan, H; Gu, C; Li, J; Qian, C; Wang, L; Yan, F; Yu, X, 2015) |
| "The present study aimed to investigate the effects of melatonin (MEL) intake on systemic inflammation and immune responses during intradialytic exercise." | 5.41 | Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients. ( Agrebi, I; Ayadi, F; Ben Dhia, I; Ben Hmida, M; Chaker, H; Driss, T; Hachicha, H; Hammouda, O; Kallel, C; Kammoun, K; Maaloul, R; Marzougui, H; Masmoudi, H; Turki, M, 2021) |
| "In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks." | 5.41 | The Effect of Melatonin on Periodontitis. ( Bábíčková, J; Baňasová, L; Celec, P; Chobodová, P; Janko, J; Konečná, B; Tóthová, Ľ, 2021) |
| "Melatonin was applied directly before and 2 h after LPS administration (3 mg/kg, each)." | 5.40 | Immune stimulation by exogenous melatonin during experimental endotoxemia. ( Brencher, L; Broecker-Preuss, M; de Groot, H; Effenberger-Neidnicht, K; Hamburger, T; Petrat, F, 2014) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 5.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Melatonin has been known to affect a variety of astrocytes functions in many neurological disorders but its mechanism of action on neuroinflammatory cascade and alpha-7 nicotinic acetylcholine receptor (α7-nAChR) expression are still not properly understood." | 5.38 | Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2012) |
| "Melatonin, which plays an important role in circadian rhythm regulation, is highly potent endogenous free radical scavenger and antioxidant." | 5.36 | Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain. ( Agrawal, R; Nath, C; Shukla, R; Tyagi, E, 2010) |
| "Treatment of melatonin with MPTP reversed all these MPTP-induced changes." | 5.36 | The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2010) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 5.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Melatonin treatment in the morning (P < 0." | 5.34 | Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine. ( Bilgihan, A; Caglar, G; Erdogan, D; Guney, HZ; Guney, Y; Hicsonmez, A; Kurtman, C; Nalca Andrieu, M; Ozel Turkcu, U; Take, G; Uluoglu, C; Yucel, B; Zengil, H, 2007) |
| "Melatonin was administered as an antioxidant." | 5.32 | Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. ( Nava, M; Quiroz, Y; Rodriguez-Iturbe, B; Vaziri, N, 2003) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 5.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| "We describe the protocol for a clinical trial design evaluating the effects of simultaneous administration of propolis and melatonin in patients with primary sepsis." | 5.30 | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. ( Bagheri Moghaddam, A; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Jarahi, L; Mazloumi Kiapey, SS; Nematy, M; Norouzy, A; Pahlavani, N; Reazvani, R; Safarian, M; Sedaghat, A, 2019) |
| " The tight connection between adipose tissue and the immune system has been demonstrated to play a crucial role in inflammation, and melatonin is important for circadian rhythm regulation and metabolic homeostasis, in which it orchestrates several molecular mechanisms involved in obesity and associated inflammation." | 5.22 | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review. ( Amatrudo, F; Colao, A; Graziadio, C; Liccardi, A; Montò, T; Muscogiuri, G; Negri, M; Patalano, R; Pivonello, C; Pivonello, R, 2022) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 5.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| " Exercise was associated with a significant increase in TNF-α, IL-6, IL-1ra (in blood), and also an increase in 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane levels (in urine), and indicated the degree of oxidative stress and inflammation induced." | 5.15 | Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. ( De Teresa, C; Díaz-Castro, J; García, C; Guisado, IM; Guisado, R; Kajarabille, N; Ochoa, JJ, 2011) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| " It has been suggested that melatonin reduces inflammation by its radical scavenging properties; however, the results of the previous studies are inconclusive." | 5.05 | Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials. ( Alizadeh, S; Emami, M; Janmohammadi, P; Khorshidi, M; Kord-Varkaneh, H; Mohammed, SH; Mousavi, SM; Saedisomeolia, A; Zarezadeh, M, 2020) |
| "Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity." | 5.01 | Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. ( Hardeland, R, 2019) |
| " A wide array of biochemical processes underlie MDD presentations and their shift to a recurrent, neuroprogressive course, including: increased immune-inflammation, tryptophan catabolites (TRYCATs), mitochondrial dysfunction, aryl hydrocarbonn receptor activation, and oxidative and nitrosative stress (O&NS), as well as decreased sirtuins and melatonergic pathway activity." | 4.98 | Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. ( Anderson, G, 2018) |
| "Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity." | 4.98 | The multiple functions of melatonin in regenerative medicine. ( Darband, SG; Jahanban-Esfahlan, R; Kaviani, M; Majidinia, M; Mohebbi, I; Nabavi, SM; Rastegar, M; Reiter, RJ; Shakouri, SK; Yousefi, B, 2018) |
| "Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent." | 4.98 | Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension. ( Diez, ER; Ferder, L; Manucha, W; Prado, NJ, 2018) |
| "This systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to determine the effect of melatonin supplementation on the inflammatory markers among individuals with metabolic syndrome (MetS) and related disorders." | 4.98 | The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials. ( Akbari, M; Amirani, E; Asemi, Z; Heydari, ST; Lankarani, KB; Ostadmohammadi, V; Reiter, RJ; Tabrizi, R, 2018) |
| " Since there is a direct relationship between chronic inflammation and many emerging disorders like cancer, oral diseases, kidney diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of this review is to describe the use and role of melatonin, a hormone secreted by the pineal gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant." | 4.91 | Evaluating the Oxidative Stress in Inflammation: Role of Melatonin. ( Calpena, AC; Clares, B; Sánchez, A, 2015) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 4.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "Electrochemical arrays were used to measure the overflow of serotonin (5-HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical-induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function." | 4.31 | Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation. ( Kotecha, N; Lavoie, B; Mawe, GM; Patel, BA; Perez, F, 2023) |
| "To investigate, in the liver of adult offspring, the possible effects of melatonin supplementation in the obese mother during pregnancy and lactation." | 4.31 | Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress. ( Aguila, MB; Ajackson, M; Mandarim-de-Lacerda, CA; Marcondes-de-Castro, IA; Nagagata, BA, 2023) |
| " Although several pharmacological interventions, including melatonin and metformin, have been reported to protect against various cardiovascular diseases, their potential roles in trastuzumab-induced cardiotoxicity remain elusive." | 4.31 | Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Nawara, W; Prathumsap, N; Shinlapawittayatorn, K, 2023) |
| "In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model." | 4.31 | Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway. ( Ateş, Ş; Doğanyiğit, Z; Oflamaz, AO; Söylemez, ESA; Uçar, S; Yilmaz, S, 2023) |
| " The purpose of the current study was to reveal the possible protective effects of melatonin against AA-induced hepatic oxidative stress, hepatic inflammation, and hepatocellular proliferation in pinealectomized rats." | 4.31 | Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. ( Altinoz, E; Bicer, Y; Elbe, H; Karayakali, M; Onal, MO; Ozturk, I, 2023) |
| "Melatonin protects HNEpCs from damage in inflammation and reduces IL-33 and TSLP expression of HNEpCs." | 4.31 | Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly. ( Gong, MJ; Hu, ZZ; Lou, M; Ma, RP; Wang, YS; Zhang, HB; Zhang, Y; Zheng, GX, 2023) |
| "This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic acid (vitamin C, ASA) in treating sepsis-induced lung injury in rats." | 4.31 | Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study. ( Çiçek, B; Demir, Ö; Huyut, MT; Tavacı, T; Üstündağ, H; Yüce, N, 2023) |
| "This study suggests that maternal melatonin supplementation can shape the gut microbiota and metabolism of offspring under normal physiological conditions and protect them against LPS-induced inflammation in early life." | 4.31 | Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life. ( Cai, Y; Feng, Z; Hao, H; Ke, Q; Lai, J; Li, F; Li, S; Liu, X; Lu, Z; Ma, F; Xiao, X, 2023) |
| "To investigate the combined therapeutic potential of melatonin and ascorbic acid in mitigating sepsis-induced heart and kidney injury in male rats and assess the combination therapy's effects on inflammation, cellular damage, oxidative stress, and vascular function-related markers." | 4.31 | A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats. ( Akbaba, Ö; Demir, Ö; Doğanay, S; Huyut, MT; Kalındemirtaş, FD; Kurt, N; Özgeriş, FB; Üstündağ, H, 2023) |
| "In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process." | 4.31 | Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus). ( Gao, WT; Liu, JX; Sun, HJ; Wang, DH; Zhang, XY, 2023) |
| "Melatonin confers protection against myocardial injury by reducing inflammation and inhibiting apoptosis." | 4.31 | Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis. ( Huo, JL; Liu, ZH; Ren, K; Wu, F, 2023) |
| "The aim of this study was to investigate the effects of melatonin on the serum asymmetric dimethylarginine (ADMA) levels and the expressions of vaspin, visfatin, dimethylarginine dimethylaminohydrolase (DDAH), and signal transducer and activator of transcription-3 (STAT-3) for evaluation of endothelial function and inflammation in the hypercholesterolemic rats." | 4.31 | The effects of melatonin against atherosclerosis-induced endothelial dysfunction and inflammation in hypercholesterolemic rats. ( Aslan, G; İlhan, N; Sahin, K; Sahna, E; Sezgin, D; Tuzcu, M, 2023) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
| " Melatonin (MT) has been shown to alleviate inflammation in organs and remodel gut microbiota in animals and humans." | 4.12 | Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice. ( Du, H; Ge, L; Hou, L; Huang, K; Kang, W; Li, J; Liu, D; Liu, S; Liu, Y; Mao, X; Yin, Y, 2022) |
| "Melatonin may inhibit inflammation and associated oxidative stress on the surface of knee cartilage." | 4.12 | Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage. ( Ke, C; Li, H; Wang, J; Wang, L; Xu, J; Yang, D; Ying, H; Zhu, H, 2022) |
| "By inhibiting neuroinflammation and reducing neuronal death, melatonin promotes the recovery of neuromotor function." | 4.12 | Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. ( Dang, X; Dong, Q; Huang, H; Ma, D; Qu, Z; Wang, H, 2022) |
| "Melatonin limited the negative effects associated with alcohol consumption and low-intensity inflammation." | 4.02 | Melatonin maintains the function of the blood redox system at combined ethanol-induced toxicity and subclinical inflammation in mice. ( Kurhaluk, N; Lukash, O; Tkachenko, H; Winklewski, PJ; Wszedybyl-Winklewska, M, 2021) |
| "In this study, the combined effects of four-week swimming training and melatonin were examined on the oxidative response, inflammation, apoptosis, and angiogenesis capacity of cardiac tissue in the mouse model of diabetes." | 4.02 | Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue. ( Ahmadi, M; Bolboli, L; Haghighi, L; Hassanpour, M; Keyhanmanesh, R; Mahdipour, M; Rahbarghazi, A; Rahbarghazi, R; Siahkouhian, M; Sokouti Nasimi, F, 2021) |
| "Melatonin (MEL) shows an anti-inflammatory effect and regulates intestinal microbiota communities in animals and humans; Ochratoxin A (OTA) induces liver inflammation through intestinal microbiota." | 4.02 | Melatonin alleviates Ochratoxin A-induced liver inflammation involved intestinal microbiota homeostasis and microbiota-independent manner. ( Chen, J; Fu, Y; Huang, L; Jiang, X; Li, Y; Ma, W; Meca, G; Wang, H; Wang, S; Wang, W; Xia, D; Yang, L; Ye, H; Zhai, S; Zhang, X; Zhu, S; Zhu, Y, 2021) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 4.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 4.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation." | 4.02 | A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement. ( Alizadeh, Z; Dashti-Khavidaki, S; Ghaderkhani, S; Keyhanian, N; Pourpak, Z; Shokouhi Shoormasti, R, 2021) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 3.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| " To address this, we investigated the effect of melatonin on ischemia-induced fibrosis." | 3.96 | Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020) |
| " Liver damage, markers of glucose metabolism, inflammation, intestinal barrier function and melatonin metabolism were determined." | 3.96 | Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis. ( Baumann, A; Bergheim, I; Brandt, A; Burkard, M; Jin, CJ; Nier, A; Sellmann, C; Venturelli, S, 2020) |
| " Melatonin is a strong anti-inflammatory hormone, mediating the cytoprotective effect of a variety of retinal cells against hyperglycemia." | 3.96 | Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. ( Chen, L; Liu, W; Liu, X; Shi, Q; Song, E; Sun, Y; Tu, Y; Wang, K; Wang, X; Wang, Z; Zhao, Q; Zhu, M, 2020) |
| "We have previously shown an inverse correlation between testicular melatonin concentration and inflammation/oxidative stress-related markers levels in infertile men showing unexplained azoospermia." | 3.96 | Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology. ( Calandra, RS; Frungieri, MB; Levalle, O; Martinez, G; Matzkin, ME; Muñoz de Toro, MM; Ponzio, R; Puigdomenech, E; Riviere, E; Rossi, SP; Tavalieri, YE; Terradas, C, 2020) |
| "Inflammation is associated with injury to immature lungs, and melatonin administration to preterm newborns with acute respiratory distress improves pulmonary outcomes." | 3.96 | Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation. ( Burd, I; Chudnovets, A; Kang, Y; Lee, JY; Lei, J; Na, Q; Shin, HE; Shin, NE; Song, H, 2020) |
| " This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury." | 3.96 | Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. ( Chao, LM; Guo, A; Guo, SN; Li, Y; Liu, C; Lv, WJ; Qu, Q; Tang, XG; Wei, GW; Xiong, Y; Yin, YL; Yu, LZ; Zhou, JH, 2020) |
| "Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism has not been identified." | 3.96 | Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury. ( Cui, JW; Ma, X; Wei, LL; Yang, B; Zang, LE; Zhang, MY, 2020) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 3.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| "Both CpG oligodeoxynucleotide (CpG-ODN) and melatonin have been reported to induce Th1 response and contribute to allergic asthma resistance." | 3.91 | Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome. ( Fan, XY; Fei, GH; Wu, HM; Xie, QM; Xu, J; Zhao, CC, 2019) |
| " N-acetyl-5-methoxytryptamine (melatonin) is a natural hormone secreted by the pineal gland which has been shown to participate in several physiological and pathological progresses, such as aging, anti-inflammation, anti-apoptosis and autophagy regulation." | 3.91 | Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. ( Chen, Z; Han, Y; He, F; Qian, L; Su, Q; Tan, J; Yan, M; Zhang, Q; Zhang, Y, 2019) |
| "The anti-catabolic bisphosphonate alendronate is considered as the first-line medical treatment in post-menopausal osteoporosis; but several side effects, including gastric mucosal injury, are associated with its use." | 3.91 | Melatonin supports alendronate in preserving bone matrix and prevents gastric inflammation in ovariectomized rats. ( Akkiprik, M; Çilingir-Kaya, ÖT; Ercan, F; Gürler, EB; Peker Eyüboglu, I; Reiter, RJ; Yegen, BÇ, 2019) |
| "Melatonin pre-treatment protected the heart from MI/R by reducing myocardial oedema and inflammation, attenuating oxidative stress, and decreasing myocardial apoptosis." | 3.91 | Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway. ( Chen, T; Deng, C; Jules, KED; Lan, H; Li, H; Liu, Y; Masau, JF; Su, Y; Wang, J; Wei, X, 2019) |
| "Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury." | 3.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| " The aim of the present study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of antibiotics and/or melatonin treatments on diet-induced hepato-intestinal dysfunction and inflammation." | 3.91 | The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats. ( Akdeniz, E; Aksu, B; Arabacı Tamer, S; Bagriacik, F; Cayirli, YB; Çetinel, Ş; Cilingir Kaya, ÖT; Kahraman, MM; Onur, ND; Sahin, D; Yeğen, BÇ; Yildirim, A; Yuksel, M, 2019) |
| "To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis." | 3.88 | Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018) |
| "This study demonstrated that melatonin pretreatment attenuated lung ischaemia-reperfusion injury via inhibition of oxidative stress, inflammation and apoptosis." | 3.88 | Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. ( Wang, JJ; Wang, JS; Wang, ML; Wang, WD; Wei, CH; Zhang, J, 2018) |
| "Melatonin may protect against HS-induced myocardial injury in male rats by mitigating oxidative stress and inflammation." | 3.88 | Melatonin provides protection against heat stroke-induced myocardial injury in male rats. ( Chang, CP; Chao, CM; Lin, CH; Lin, MT; Lin, S; Lin, X; Liu, L; Wen, S; Ye, Z; Zhao, T; Zuo, D, 2018) |
| " Melatonin can improve peripheral nerve recovery by inhibiting oxidative stress and inflammation after traumatic insults." | 3.88 | 3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration. ( Cheng, Y; Fan, C; Fang, Z; Han, Q; Ouyang, Y; Qian, Y; Song, J; Yuan, WE; Zhao, X, 2018) |
| " Melatonin, a potent free radical scavenger and broad spectrum antioxidant, has been shown to counteract inflammation and apoptosis in brain injury." | 3.88 | Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. ( Calvo-Soto, M; García, C; González, P; Hyacinthe, B; Paredes, SD; Rancan, L; Rodríguez-Bobada, C; Tresguerres, JAF; Vara, E, 2018) |
| " Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase-1, -3, and -9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation." | 3.88 | Melatonin improves quality and longevity of chronic neural recording. ( Carlisle, DL; Cui, XT; Friedlander, RM; Golabchi, A; Kozai, TDY; Li, X; Wu, B, 2018) |
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 3.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| " The altered proteins are related to the development of liver pathology, such as cirrhosis (α1-antiproteinase), thrombosis (fibrinogen, plasminogen), and inflammation (mannose-binding protein A, complement C4, complement factor B), contributing to liver steatosis or hepatic cell death." | 3.85 | High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation. ( Govitrapong, P; Isarankura-Na-Ayudhya, C; Kitidee, K; Klosen, P; Pannengpetch, S; Wongchitrat, P, 2017) |
| "Increased levels of AANAT, melatonin, and MT1 in the inflamed oral mucosal tissue of OLP patients imply that chronic inflammation may induce the local biosynthesis of melatonin via AANAT, and may enhance the action of melatonin via MT1." | 3.85 | Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation. ( Chaiyarit, P; Hormdee, D; Klanrit, P; Luengtrakoon, K; Noisombut, R; Vichitrananda, V; Wannakasemsuk, W, 2017) |
| "The objectives of this study were to determine the effectiveness of melatonin in cell viability and expression of proteins involved in angiogenesis and inflammation in triplenegative mammary tumor cell line (MDA-MB-231) and in co-culture with CAFs." | 3.83 | Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts. ( Bordin, NA; Borin, TF; Cardoso, JP; Corrêa, LA; Gelaleti, GB; Jardim-Perassi, BV; Lacerda, JZ; Lopes, JR; Maschio-Signorini, LB; Moschetta, MG; Roela, RA; Zuccari, DA, 2016) |
| "Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood." | 3.83 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. ( Chao, H; Hou, L; Ji, J; Li, Z; Lin, C; Liu, N; Liu, Y; Xu, X, 2016) |
| "To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation." | 3.83 | Melatonin modulates adiponectin expression on murine colitis with sleep deprivation. ( Baik, HW; Choi, JW; Chung, SH; Gye, MC; Jun, JH; Kim, EK; Kim, JB; Kim, SH; Kim, TK; Lim, JY; Park, YS; Sull, JW; Sung, HJ, 2016) |
| " We aimed to investigate the proteins related to oxidative stress, inflammation and apoptosis in liver tissue subjected to IH as a simulation of sleep apnea in conjunction with the administration of either melatonin (MEL, 200 μL/kg) or N-acetylcysteine (NAC, 10 mg/kg)." | 3.81 | Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea. ( Andrade, CF; da Rosa, DP; e Silva, MB; Fiori, CZ; Forgiarini, LF; Marroni, NP; Martinez, D, 2015) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 3.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| "In this study, the relationship between the plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several intercellular interactions including inflammatory and immune responses, and early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined." | 3.81 | The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery. ( Akçalı, A; Ali Elçi, M; Deniz, H; Geyik, S; Hafız, E; Murat Geyik, A; Yiğiter, R, 2015) |
| "Melatonin seems to exert a protective effect on arteries from both ob/ob and CLM, counteracting the adverse effect of hypoxia and iberiotoxin." | 3.80 | Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin. ( Agabiti-Rosei, C; Agabiti-Rosei, E; De Ciuceis, C; Favero, G; Heagerty, AM; Porteri, E; Rezzani, R; Rizzoni, D; Rodella, LF; Rossini, C; Withers, SB, 2014) |
| "We aimed to evaluate the effects of two immune regulatory factors, interleukin-4 (IL-4) and melatonin, on several inflammatory mediators that are involved in inflammation and angiogenesis in diabetic retinopathy (DR), in high glucose or interleukin-1β (IL-1β) induced primary human retinal endothelial cells (RECs) and human retinal pigment epithelial (RPE) cells." | 3.80 | Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells. ( Hu, A; Hu, X; Luo, Y; Sun, W; Tang, S; Xie, M, 2014) |
| "The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats." | 3.80 | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats. ( Cano Barquilla, P; Cardinali, DP; Esquifino, AI; Fernández-Mateos, P; Jiménez-Ortega, V; Pagano, ES, 2014) |
| "The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi." | 3.80 | Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. ( Kireev, RA; Tresguerres, JA; Vara, E; Viña, J, 2014) |
| " We tested the hypothesis that melatonin ameliorates the CIH-induced lipid peroxidation, local inflammation and cellular injury in rat adrenal medulla." | 3.80 | Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla. ( Fung, ML; Liu, Y; Tipoe, GL, 2014) |
| "We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats." | 3.79 | Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013) |
| "Thirty rats were divided into five groups: a control group, an acetic acid-induced colitis group, a group treated with melatonin before colitis induction, a group treated short-term after colitis induction, and a group treated long-term after colitis induction." | 3.79 | The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. ( Blann, A; El Sers, DA; Idriss, NK; Jaumdally, RJ; Sayyed, HG, 2013) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 3.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model." | 3.79 | Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway. ( Chen, G; Ji, C; Wang, Z; Wu, L; You, W, 2013) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 3.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "The aim of this study was to investigate the effects of melatonin on low-grade inflammation and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 3.79 | Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. ( Adem, A; Agil, A; Fernández-Vázquez, G; Ibán-Arias, R; Jiménez-Aranda, A; Marchal, JA; Navarro-Alarcón, M; Reiter, RJ, 2013) |
| "This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties." | 3.79 | Endothelial and vascular smooth muscle cell dysfunction mediated by cyclophylin A and the atheroprotective effects of melatonin. ( Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A, 2013) |
| "Human endothelial cells were treated with lipopolysaccharide (LPS) plus peptidoglycan G (PepG) to simulate sepsis, in the presence of melatonin, 6-hydroxymelatonin, tryptamine, or indole-3-carboxylic acid." | 3.77 | Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. ( Almawash, AM; Galley, HF; Lowes, DA; Reid, VL; Webster, NR, 2011) |
| "Previous reports suggest that melatonin may play an important role in visceral nociception and neurogenic inflammation." | 3.76 | Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. ( Mickle, A; Miranda, A; Sengupta, JN; Shahmohammadi, G; Sood, M; Zhang, Z, 2010) |
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 3.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "In summary, a daily oscillation of circadian clock genes and inflammatory cytokines as well as the ability of melatonin to function as a daily mediator of inflammation provides valuable information to aid in deciphering how the circadian timing system regulates immune function at the molecular level." | 3.76 | Inflammation in the avian spleen: timing is everything. ( Bailey, MJ; Morgan, LW; Naidu, KS, 2010) |
| "The aim of this study was to investigate the effect of aging and ovariectomy on various physiological parameters related to inflammation and oxidative stress in livers obtained from old female rats, and the influence of chronic administration of melatonin on these animals." | 3.74 | Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage. ( Ariznavarreta, C; Garcia, C; Kireev, RA; Tresguerres, AC; Tresguerres, JA; Vara, E, 2008) |
| " Here we report the beneficial effects of melatonin on inflammation associated with A beta vaccination in the central and peripheral nervous system of mice." | 3.74 | Anti-inflammatory effect of melatonin on A beta vaccination in mice. ( Ashok, BS; Baben, B; Jayakumar, R; Jebaraj, WC; Jesudason, EP; Kirubagaran, R; Masilamoni, JG, 2007) |
| "All inflammation parameters were increased by acetic acid-induced colitis or ethanol-induced gastric ulcer compared with the control group." | 3.73 | Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes. ( Cevík, H; Ercan, F; Erkanli, G; Işman, CA; Yeğen, BC, 2005) |
| "Our aim was to determine 24-hour patterns of serum melatonin and their relationship to overnight decline in physiology in subjects with nocturnal asthma, non-nocturnal asthma, and in healthy controls." | 3.72 | Elevated serum melatonin is associated with the nocturnal worsening of asthma. ( Ellison, MC; Kraft, M; Martin, RJ; Sutherland, ER, 2003) |
| "The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat." | 3.72 | Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 3.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "Adrenal cortical hormones are important for the maintenance of the diurnal rhythm of chronic inflammation (paw swelling and vascular permeability), probably by promoting a nocturnal surge of melatonin, which is the hormone that modulates the diurnal variation of chronic inflammation." | 3.71 | Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice. ( Lopes, C; Mariano, M; Markus, RP, 2001) |
| "The aim of the present study was to investigate the effect of melatonin on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role." | 3.70 | Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. ( Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E, 1999) |
| "Melatonin can enhance the intestinal mucosal barrier, alter the composition of intestinal bacteria in favor of bacteria with anti-inflammatory properties, regulate the immune response, alleviate inflammation and attenuate oxidative stress." | 3.01 | Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application. ( Alemi, F; Alipourian, A; Khazaie, S; Malakoti, F; Moein, S; Qujeq, D; Vaghari-Tabari, M; Yousefi, B, 2023) |
| "Melatonin is a natural molecule present throughout both the plant and animal kingdoms." | 3.01 | Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective. ( Asemi, R; Asemi, Z; Badehnoosh, B; Rajabpoor Nikoo, N; Reiter, RJ; Shafabakhsh, R; Sharifi, M, 2023) |
| "Cancer cachexia is a multi-organ syndrome with unintentional weight loss, sarcopenia, and systemic inflammation." | 3.01 | Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia. ( Grundmann, O; Yoon, SL, 2023) |
| "Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies." | 2.82 | Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved. ( Chuffa, LGA; Manucha, W; Martín Giménez, VM; Reiter, RJ; Simão, VA, 2022) |
| "Melatonin is a neuroendocrine hormone that is synthesized and released primarily at night from the mammalian pineal gland." | 2.82 | Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight. ( Chung, JP; Fang, L; Hung, SW; Li, Y; Man, GC; Wang, CC; Zhang, R; Zhang, T, 2022) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 2.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| "Melatonin treatment in the perioperative period did not reduce the oxidative and inflammatory parameters measured in this study." | 2.75 | No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial. ( Gögenur, I; Kücükakin, B; Lykkesfeldt, J; Reiter, RJ; Rosenberg, J; Wilhelmsen, M, 2010) |
| " Treatment of patients undergoing major aortic surgery with melatonin intravenously up to 60 mg in the intraoperative phase was safe and without complications." | 2.73 | Utility of melatonin to treat surgical stress after major vascular surgery--a safety study. ( Gögenur, I; Kücükakin, B; Lykkesfeldt, J; Nielsen, HJ; Reiter, RJ; Rosenberg, J, 2008) |
| "Melatonin is a highly conserved molecule found in prokaryotes and eukaryotes that acts as the darkness hormone, translating environmental lighting to the whole body, and as a moderator of innate and acquired defense, migration, and cell proliferation processes." | 2.72 | Possible Role of Pineal and Extra-Pineal Melatonin in Surveillance, Immunity, and First-Line Defense. ( da Silveira Cruz-Machado, S; Fernandes, PA; Ferreira, ZS; Markus, RP; Sousa, KS, 2021) |
| "Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it." | 2.72 | Ischemic stroke, obesity, and the anti-inflammatory role of melatonin. ( Govitrapong, P; Tocharus, C; Tocharus, J; Yawoot, N, 2021) |
| "Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few." | 2.72 | Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021) |
| " An amount of 1 to 2 g per day of vitamin C demonstrated efficacy both in CRP and endothelial function, and a dosage of melatonin ranging from 5 to 25 mg /day showed good evidence of efficacy in CRP, TNF and IL6." | 2.72 | Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. ( Argano, C; Cavezzi, A; Corrao, S; Lo Monaco, M; Mallaci Bocchio, R; Natoli, G; Troiani, E, 2021) |
| "Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders." | 2.61 | Melatonin, a toll-like receptor inhibitor: Current status and future perspectives. ( Asemi, Z; Azami, A; Gholami, MS; Mobini, M; Reiter, RJ; Tamtaji, OR, 2019) |
| " Breast cancer risk factors include smoking, alcohol consumption, personal and family history, hypertension, and hormone therapy, long-term use of nonsteroidal anti-inflammatory drugs and tobacco usage." | 2.61 | Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms. ( Amin, N; Asemi, Z; Reiter, RJ; Shafabakhsh, R, 2019) |
| "Melatonin (MLT) is an amine hormone secreted mainly by the pineal gland." | 2.61 | [Advances in the role of melatonin in infectious diseases: A review]. ( Jin, B; Ma, Y; Tang, K; Zhang, C; Zhang, Y, 2019) |
| "Melatonin also acts as a cell survival agent by modulating autophagy in various cell types and under different conditions through amelioration of oxidative stress, ER stress and inflammation." | 2.58 | Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress. ( Dehdashtian, E; Ghaznavi, H; Hosseinzadeh, A; Mehrzadi, S; Naseripour, M; Reiter, RJ; Safa, M; Yousefi, B, 2018) |
| "Melatonin is an indolamine synthesized and secreted by the pineal gland along with other extrapineal sources including immune system cells, the brain, skin and the gastrointestinal tract." | 2.58 | Role of Melatonin in the Inflammatory Process and its Therapeutic Potential. ( Ayala, A; Cano, M; Carrascal, L; Nunez-Abades, P, 2018) |
| "Melatonin is an immune modulator that displays both pro- and anti-inflammatory properties." | 2.58 | Melatonin and inflammation-Story of a double-edged blade. ( Hardeland, R, 2018) |
| "Melatonin (MLT) has been implicated in several pathophysiological states, including pain." | 2.58 | Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain. ( Comai, S; De Gregorio, D; Gobbi, G; Posa, L, 2018) |
| "Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality." | 2.55 | Geroprotectors as a therapeutic strategy for COPD - where are we now? ( Białas, AJ; Górski, P; Makowska, J; Miłkowska-Dymanowska, J; Piotrowski, WJ; Wardzynska, A, 2017) |
| "Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy." | 2.55 | Melatonin as an anti-inflammatory agent in radiotherapy. ( Motevaseli, E; Najafi, M; Rezaeyan, AH; Rezapoor, S; Salajegheh, A; Shirazi, A, 2017) |
| "The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism." | 2.50 | Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014) |
| "Melatonin has atheroprotective effects by acting on different pathogenic signaling processes; these result from its direct free radical scavenger activity, its indirect antioxidant properties and its anti-inflammatory actions." | 2.50 | Melatonin and its atheroprotective effects: a review. ( Favero, G; Reiter, RJ; Rezzani, R; Rodella, LF, 2014) |
| "5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model." | 2.50 | 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014) |
| "Treatment with melatonin is useful in a diverse range of medical conditions, including bipolar disorder, Alzheimer's disease, depression and fibromyalgia." | 2.50 | Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders. ( Anderson, G; Maes, M, 2014) |
| "Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis." | 2.49 | Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. ( Chang, DM; Chen, SJ; Huang, SH; Lin, GJ; Sytwu, HK; Wang, CH, 2013) |
| "Melatonin is a multifunctional indoleamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity." | 2.48 | Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. ( Korkmaz, A; Ma, S; Reiter, RJ; Rosales-Corral, S; Tan, DX; Topal, T, 2012) |
| "Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood." | 2.46 | Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010) |
| "Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions." | 2.46 | Melatonin: a pleiotropic molecule regulating inflammation. ( Diederich, M; Ghibelli, L; Radogna, F, 2010) |
| "Melatonin is an ancient molecule present in unicellular organisms at the very early moment of life." | 2.44 | Melatonin role in the mitochondrial function. ( Acuna-Castroviejo, D; Escames, G; Lopez, LC; Rodriguez, MI, 2007) |
| "Melatonin is believed to be an important regulator of circadian and seasonal rhythms." | 2.44 | Melatonin and its influence on immune system. ( Szczepanik, M, 2007) |
| "Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence." | 2.42 | Retardation of brain aging by chronic treatment with melatonin. ( Bondy, SC; Campbell, A; Lahiri, DK; Perreau, VM; Sharman, EH; Sharman, KZ; Zhou, J, 2004) |
| "Melatonin has been shown to possess anti-inflammatory effects, among a number of actions." | 2.41 | Melatonin and its relation to the immune system and inflammation. ( Calvo, JR; Karbownik, M; Qi, W; Reiter, RJ; Tan, DX, 2000) |
| "Treatment with melatonin has been shown to prevent in vivo the delayed vascular decompensation and the cellular energetic failure associated with shock, inflammation and ischemia/reperfusion injury." | 2.41 | Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. ( Cuzzocrea, S; Reiter, RJ, 2001) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 2.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "However, its effects against pulmonary injury promoted by copper are not explored and remain unclear so far." | 1.91 | Melatonin ameliorates chronic copper-induced lung injury. ( Ali, SA; Datusalia, AK; Flora, SJS; Gaun, S; Patwa, J; Singh, P, 2023) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 1.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Obesity is well-established as a common comorbidity in ischemic stroke." | 1.91 | Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats. ( Govitrapong, P; Sengking, J; Tocharus, C; Tocharus, J; Yawoot, N, 2023) |
| "Periodontitis is a chronic infectious disease caused by bacterial irritation." | 1.91 | Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy. ( Cui, Y; He, X; Hong, S; Hu, X; Li, X; Li, Y; Lin, K; Mao, L; Wang, X; Xia, Y, 2023) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 1.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Melatonin (Mel) has been reported for the protection against liver injury." | 1.91 | Melatonin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat's liver from the hazardous effects of CCL4. ( Farid, A; Michael, V; Safwat, G, 2023) |
| "Melatonin plays a protective role against Aβ-induced inflammation via an inflammasome-associated mechanism that is essential in inducing the active forms of cytokines and pyroptosis." | 1.91 | The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines. ( Boontor, A; Govitrapong, P; Kutpruek, S; Nopparat, C, 2023) |
| "Melatonin (MLT) is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage." | 1.72 | Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis. ( Altinoz, E; Ballur, AFH; Bicer, Y; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yigitturk, G, 2022) |
| "Melatonin was administered at 20 mg/kg during the last 2 weeks." | 1.72 | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. ( Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG, 2022) |
| " Due to extreme energy requirements and high lipid levels, the brain is more susceptible to oxidative damage during aging especially under exposure to toxic elements such as arsenic." | 1.72 | Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains. ( Abdollahzade, N; Majidinia, M; Mihanfar, A, 2022) |
| "Melatonin treatment or its co-administration with HRT upregulated the expressions of IL-10 and SIRT1, reduced the expressions of IL-6 and TNF-α, and reduced DNA damage in the hearts and thoracic aortae of non-exercised rats." | 1.72 | Melatonin Alleviates Ovariectomy-Induced Cardiovascular Inflammation in Sedentary or Exercised Rats by Upregulating SIRT1. ( Altınoluk, T; Arabacı Tamer, S; Baykal, Z; Çevik, Ö; Dur, ZS; Emran, M; Ercan, F; Korkmaz, S; Levent, HN; Ural, MA; Yeğen, BÇ; Yıldırım, A; Yüksel, M; Yüksel, RG, 2022) |
| "Melatonin has known anti-inflammatory effects." | 1.72 | Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. ( Duan, H; Ge, W; Hu, J; Li, J; Zeng, J; Zhao, X, 2022) |
| "pneumoniae-induced inflammation is necessary for the survival of patients." | 1.72 | Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase. ( Jiang, W; Liu, J; Yang, W; Zhao, X, 2022) |
| "In melatonin-treated fishes, significant amelioration of oxidative stress was observed with reduced levels of MDA and pro-inflammatory cytokines." | 1.72 | Melatonin ameliorates lipopolysaccharide induced brain inflammation through modulation of oxidative status and diminution of cytokine rush in Danio rerio. ( Chakraborty, SB; Maiti, AK; Moniruzzaman, M; Saha, I; Saha, NC, 2022) |
| " Chronic use of METH is associated with cognitive impairments in both human and animal studies, but the underlying mechanism remains unclear." | 1.62 | Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus. ( Chancharoen, P; Govitrapong, P; Lwin, T; Mukda, S; Ngampramuan, S; Pinyomahakul, J; Veschsanit, N; Viwatpinyo, K; Yang, JL, 2021) |
| "Melatonin was administered i." | 1.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Sarcopenia is one of the most common features of cirrhosis, contributing to morbidity and mortality in this population." | 1.62 | Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise. ( Colares, JR; da Fonseca, SRB; Dias, AS; Lehmann, M; Marroni, CA; Marroni, NAP; Martins, GDS; Miguel, FM; Picada, JN; Rosa, CGS, 2021) |
| "Melatonin (ML) is a potent antioxidant that reduces oxidative stress." | 1.62 | Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats. ( Ahmed-Farid, OA; Al-Tamimi, J; Alhazza, IM; Bashandy, SAE; Ebaid, H; Omara, EA, 2021) |
| "Melatonin has been confirmed to be useful in various diseases, including Alzheimer's disease, liver injuries and diseases, and cancers, while its role in IBDs remains unclear." | 1.62 | Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants. ( Yuan, XQ; Zhang, XM, 2021) |
| "Mice treated with Luzindole, LPS, and Luzindole+LPS showed villus height shortening." | 1.62 | Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice. ( Bruin, PFC; Bruin, VMS; Duarte, ASG; Matos, RS; Oriá, RB; Pinto, DV; Santos, FA; Viana, AFSC, 2021) |
| "Melatonin-treated mice exhibited an enhancement in SIRT1 expression with the reduction in p65 acetylation, which decreased the level of inflammatory mediators induced by CS." | 1.56 | Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. ( Kim, JC; Kim, JS; Kim, MS; Kim, SH; Ko, JW; Park, G; Shin, IS; Shin, NR, 2020) |
| "Melatonin was expressed in healthy pulpal tissue within the odontoblastic zone, cell-rich zone, and in the pulpal connective tissue." | 1.56 | Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses. ( Arayatrakoollikit, U; Jit-Armart, P; Kantrong, N, 2020) |
| "Melatonin treatment significantly abolished the effects of LPS, as demonstrated by improved depressive-like behaviors, normalized autophagy-related gene expression, and reduced levels of cytokines." | 1.56 | Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation. ( Ali Shah, F; Ali, T; Hao, Q; Li, S; Li, W; Liu, G; Liu, Z; Murtaza, I; Rahman, SU; Yang, X; Zhang, Z, 2020) |
| "Our study demonstrated that sleep deprivation resulted in homeostasis disorder of colon." | 1.56 | Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2020) |
| "Treatment with melatonin after whole-body irradiation led to significant mitigation of radiation toxicity in both small and large intestines." | 1.56 | Mitigation of Radiation-Induced Gastrointestinal System Injury by Melatonin: A Histopathological Study. ( Bagheri, H; Javadi, A; Najafi, M; Sadeghi, H; Shekarchi, B, 2020) |
| "Non-alcoholic fatty liver disease (NAFLD) is the hepatic side of the metabolic syndrome." | 1.51 | Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. ( De Petro, G; García-Gómez, R; Grossi, I; Lavazza, A; Monsalve, M; Patel, GA; Rezzani, R; Salvi, A; Stacchiotti, A, 2019) |
| "By day 28 after IS, the brain infarct area (BIA) was lowest in group 1, highest in group 2, significantly higher in groups 3 and 4 than in group 5, but not different between groups 3 and 4." | 1.51 | Combined Therapy With Hyperbaric Oxygen and Melatonin Effectively Reduce Brain Infarct Volume and Preserve Neurological Function After Acute Ischemic Infarct in Rat. ( Chen, KH; Chen, YL; Ko, SF; Lee, MS; Lin, KC; Wallace, CG; Yip, HK, 2019) |
| "Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties." | 1.51 | Melatonin improves the structure and function of autografted mice ovaries through reducing inflammation: A stereological and biochemical analysis. ( Noori Hassanvand, M; Shojafar, E; Soleimani Mehranjani, M, 2019) |
| "Melatonin has been shown to reduce oxidative stress and mitigate hypercoagulability." | 1.51 | Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model. ( Burd, I; Dong, J; Jia, B; Jones-Beatty, K; Lee, JY; Lei, J; Li, S; McLane, MW; Na, Q; Ozen, M; Shin, NE, 2019) |
| "Melatonin was administered 1, 24, 48 and 72 h after TBI through i." | 1.48 | Does the administration of melatonin during post-traumatic brain injury affect cytokine levels? ( Asadikorom, G; Dehghan, F; Khaksari, M; Najafi, A; Shahrokhi, N; Soltani, Z, 2018) |
| "The degree of complexity of a cancer system could be vast involving multiple endogenous and exogenous agents interacting with the over 10 trillion cells comprising the body." | 1.48 | A complex systems approach to cancer prevention. ( Jupp, PW, 2018) |
| "As melatonin is a natural antioxidant molecule, detailed pharmacokinetic and pharmacodynamic studies are expected to establish it as an effective nephro-protective agent in future." | 1.48 | Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice. ( Dutta, S; Mahalanobish, S; Sadhukhan, P; Saha, S; Sil, PC, 2018) |
| "Melatonin has been shown to exert pleiotropic protective actions, such as anti-inflammation and anti-oxidative stress on many cell- and organ-types." | 1.48 | Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. ( Jang, M; Kleber, A; Manz, A; Volk, T, 2018) |
| "Melatonin (MTG) plays critical roles in circadian rhythm disorders, Alzheimer's disease, and other neurological disorders." | 1.48 | Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder. ( Hahm, DH; Lee, B; Lee, H; Shim, I, 2018) |
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 1.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease." | 1.48 | Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 1.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "Melatonin was injected intraperitoneally 1 h before lipopolysaccharide injection and then once a day for 1 week to evaluate the long-term effects." | 1.46 | Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats. ( Fang, M; Gao, Z; Hu, Y; Jiang, H; Li, Z; Lin, Z; Pan, S; Wang, Z; Xiao, J; Xu, K; Zhang, H, 2017) |
| "Systemic inflammation is known to impair the microcirculation in intestine and other organs as a result of multifactorial events." | 1.46 | Melatonin reduces changes to small intestinal microvasculature during systemic inflammation. ( de Groot, H; Effenberger-Neidnicht, K; Lansink, MO; Patyk, V, 2017) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 1.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 1.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| "Preterm birth is a major contributor to early and delayed physical and cognitive impairment." | 1.46 | Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice. ( Aisemberg, J; Bariani, MV; Correa, F; Domínguez Rubio, AP; Dorfman, D; Franchi, AM; Rosenstein, RE; Zorrilla Zubilete, M, 2017) |
| "Melatonin has been shown to have anti-inflammatory and anti-allodynia effects in both preclinical and clinical studies." | 1.46 | Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain. ( Cui, W; Li, LB; Li, YY; Tian, BP; Wang, YS; Zhang, GS; Zhang, ZC, 2017) |
| "Melatonin (MLT) has been reported with an effective antioxidant activity." | 1.46 | Protective effect of melatonin on the development of abdominal aortic aneurysm in a rat model. ( Cong, Z; Hao, S; Huang, H; Jing, H; Li, K; Li, P; Shen, Y; Tang, L, 2017) |
| "Excess weight and obesity are severe public health threats worldwide." | 1.46 | Melatonin prevents obesity through modulation of gut microbiota in mice. ( Hong, F; Jia, L; Jin, X; Wang, J; Wang, S; Xu, P; Xue, T; Zhai, Y, 2017) |
| "Colitis was induced by intracolonic (i." | 1.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Melatonin (5 mg/kg) was administered i." | 1.43 | Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Chalon, S; Favrais, G; Gressens, P; Longini, M; Saliba, E, 2016) |
| "Peritoneal dialysis (PD)-associated peritoneal fibrosis is a serious complication in patients with chronic renal failure on dialysis maintenance." | 1.43 | Molecular mechanisms of melatonin in the reversal of LPS-induced EMT in peritoneal mesothelial cells. ( Shi, S; Sun, L; Wen, W; Zhang, Y; Zhao, Y, 2016) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 1.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Melatonin treatment reversed the increase of serum TNF-α levels and histopathological injury in renal tissue after renal IR." | 1.42 | Effects of melatonin on the serum levels of pro-inflammatory cytokines and tissue injury after renal ischemia reperfusion in rats. ( Baba, F; Hekimoglu, A; Oguz, E; Ozbilge, H; Tabur, S; Yerer, MB; Yilmaz, Z, 2015) |
| "Melatonin (mel) acts as an anti-inflammatory factor and has been reported to modulate TLRs in some aggressive tumor cell types." | 1.42 | Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer. ( Chuffa, LG; Delazari Dos Santos, L; Domeniconi, RF; Fávaro, WJ; Ferreira Seiva, FR; Fioruci-Fontanelli, BA; Martinez, FE; Martinez, M; Mendes, LO; Pinheiro, PF, 2015) |
| "Melatonin was administrated intraperitoneally (30 mg/kg)." | 1.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Melatonin was tested for its effect on Th1, Th17 and T regulatory (Treg) cells in the lymph nodes and CNS of immunodominant peptide of myelin oligodendrocyte glycoprotein (pMOG)-immunized and EAE mice, respectively." | 1.42 | Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance. ( Álvarez-Sánchez, N; Carrillo-Vico, A; Cruz-Chamorro, I; Fernández-Santos, JM; Guerrero, JM; Lardone, PJ; López-González, A; Martínez-López, A; Utrilla, JC, 2015) |
| "Melatonin is a strong antioxidant that has beneficial effects against SAH in rats, including reduced mortality and reduced neurological deficits." | 1.42 | Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. ( Cao, S; Chen, G; Chen, J; Duan, H; Gu, C; Li, J; Qian, C; Wang, L; Yan, F; Yu, X, 2015) |
| "Melatonin was applied directly before and 2 h after LPS administration (3 mg/kg, each)." | 1.40 | Immune stimulation by exogenous melatonin during experimental endotoxemia. ( Brencher, L; Broecker-Preuss, M; de Groot, H; Effenberger-Neidnicht, K; Hamburger, T; Petrat, F, 2014) |
| "Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined." | 1.40 | Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin. ( Jiao, M; Liu, C; Liu, X; Ma, P; Wu, J; Wu, Y; Yan, B; Yang, X; Zeng, Q, 2014) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 1.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Pretreatment with melatonin further enhanced the expression of HO-1 and significantly reduced iNOS expression." | 1.39 | Melatonin improves bladder symptoms and may ameliorate bladder damage via increasing HO-1 in rats. ( Guo, JX; Lu, GS; Song, B; Zhang, QH; Zhou, ZS, 2013) |
| "Melatonin has been known to affect a variety of astrocytes functions in many neurological disorders but its mechanism of action on neuroinflammatory cascade and alpha-7 nicotinic acetylcholine receptor (α7-nAChR) expression are still not properly understood." | 1.38 | Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2012) |
| "Treatment with melatonin significantly reduced hepatic damage, being oral administration more effective." | 1.37 | [Effect of pretreatment with melatonin on the oxidative and inflammatory damage induced by hepatic ischemia/reperfusion in Zucker rats]. ( Hernández, JA, 2011) |
| "Melatonin, which plays an important role in circadian rhythm regulation, is highly potent endogenous free radical scavenger and antioxidant." | 1.36 | Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain. ( Agrawal, R; Nath, C; Shukla, R; Tyagi, E, 2010) |
| "Treatment of melatonin with MPTP reversed all these MPTP-induced changes." | 1.36 | The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2010) |
| "Treatment with melatonin improved oxygenation and decreased histological lung injury but significantly increased oxidative stress quantified by malondialdehyde levels." | 1.35 | Effects of melatonin in an experimental model of ventilator-induced lung injury. ( Albaiceta, GM; Astudillo, A; Diaz, E; García-Prieto, E; Parra, D; Pedreira, PR; Taboada, F, 2008) |
| "Melatonin pretreatment significantly reduced the haemorrhagic lesions and decreased esophageal lipid peroxidation aggravated by RE." | 1.35 | Melatonin protects against experimental reflux esophagitis. ( Lahiri, S; Palit, G; Pant, KK; Rasheed, N; Singh, P; Singh, S, 2009) |
| "Melatonin is a mammalian hormone that has a great variety of effects." | 1.35 | [Determination of melatonin receptors in human blood mononuclear cells: clinical and experimental rationale]. ( Gorchakova, MV; Rezvan, TA; Semenov, DIu; Shapkina, LG; Sokolov, AV; Stepnov, IA; Tonoian, AG; Vasil'ev, VB; Zyeva, EE, 2009) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 1.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Treatment with melatonin significantly attenuated the increased level of serum aminotransferase, reduced the severe extent of hepatic cell damage, steatosis and the immigration of inflammatory cells, but had no effects on hepatic expression of lipogenic genes." | 1.35 | Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. ( Hu, S; Huang, D; Jiang, X; Shen, G; Yin, S, 2009) |
| "Melatonin tended to enhance the reaction of younger animals to LPS but suppressed the inflammatory response of older mice." | 1.35 | Melatonin causes gene expression in aged animals to respond to inflammatory stimuli in a manner differing from that of young animals. ( Bondy, SC; Sharman, EH; Sharman, KG, 2008) |
| "Melatonin treatment significantly improved the quality of scarring, both in terms of maturity and orientation of collagen fibres." | 1.35 | Melatonin accelerates the process of wound repair in full-thickness incisional wounds. ( Appleton, I; Clarkson, AN; Hall, I; Kapoor, M; Pugazhenthi, K, 2008) |
| "Melatonin treatment in the morning (P < 0." | 1.34 | Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine. ( Bilgihan, A; Caglar, G; Erdogan, D; Guney, HZ; Guney, Y; Hicsonmez, A; Kurtman, C; Nalca Andrieu, M; Ozel Turkcu, U; Take, G; Uluoglu, C; Yucel, B; Zengil, H, 2007) |
| "Melatonin was administered as an antioxidant." | 1.32 | Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. ( Nava, M; Quiroz, Y; Rodriguez-Iturbe, B; Vaziri, N, 2003) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 1.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.27) | 18.7374 |
| 1990's | 4 (1.06) | 18.2507 |
| 2000's | 41 (10.90) | 29.6817 |
| 2010's | 195 (51.86) | 24.3611 |
| 2020's | 135 (35.90) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, W | 1 |
| Bi, Y | 2 |
| Xue, P | 1 |
| Zhang, Y | 14 |
| Gao, X | 4 |
| Wang, Z | 16 |
| Li, M | 1 |
| Baudy-Floc'h, M | 1 |
| Ngerebara, N | 1 |
| Gibson, KM | 1 |
| Bi, L | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Galijasevic, S | 1 |
| Ma, S | 3 |
| Zhu, L | 5 |
| Fan, X | 1 |
| Luo, T | 1 |
| Liu, D | 5 |
| Liang, Z | 1 |
| Hu, X | 4 |
| Shi, T | 1 |
| Tan, W | 2 |
| Kilic, U | 1 |
| Elibol, B | 1 |
| Beker, M | 1 |
| Altug-Tasa, B | 1 |
| Caglayan, AB | 1 |
| Beker, MC | 1 |
| Yilmaz, B | 1 |
| Kilic, E | 1 |
| Yang, J | 4 |
| Wang, T | 3 |
| Jin, X | 3 |
| Wang, G | 2 |
| Zhao, F | 2 |
| Jin, Y | 2 |
| Kanova, M | 1 |
| Kohout, P | 1 |
| Yawoot, N | 3 |
| Sengking, J | 2 |
| Wicha, P | 1 |
| Govitrapong, P | 9 |
| Tocharus, C | 4 |
| Tocharus, J | 4 |
| Markus, RP | 6 |
| Sousa, KS | 1 |
| da Silveira Cruz-Machado, S | 3 |
| Fernandes, PA | 3 |
| Ferreira, ZS | 2 |
| Martín Giménez, VM | 4 |
| Chuffa, LGA | 1 |
| Simão, VA | 1 |
| Reiter, RJ | 33 |
| Manucha, W | 5 |
| Pivonello, C | 1 |
| Negri, M | 1 |
| Patalano, R | 1 |
| Amatrudo, F | 1 |
| Montò, T | 1 |
| Liccardi, A | 1 |
| Graziadio, C | 1 |
| Muscogiuri, G | 1 |
| Pivonello, R | 1 |
| Colao, A | 1 |
| Ajoolabady, A | 1 |
| McClements, DJ | 1 |
| Lip, GYH | 1 |
| Richardson, DR | 1 |
| Klionsky, DJ | 1 |
| Ren, J | 2 |
| Guan, Q | 1 |
| Cao, J | 3 |
| Dong, Y | 4 |
| Chen, Y | 8 |
| Hemati, K | 1 |
| Pourhanifeh, MH | 1 |
| Fatemi, I | 1 |
| Hosseinzadeh, A | 2 |
| Mehrzadi, S | 2 |
| Ballur, AFH | 1 |
| Altinoz, E | 2 |
| Yigitturk, G | 1 |
| Onal, MO | 2 |
| Elbe, H | 3 |
| Bicer, Y | 2 |
| Karayakali, M | 2 |
| Demir, M | 1 |
| Shen, S | 2 |
| Liao, Q | 1 |
| Wong, YK | 1 |
| Chen, X | 4 |
| Yang, C | 1 |
| Xu, C | 1 |
| Sun, J | 3 |
| Wang, J | 14 |
| Pahlavani, N | 2 |
| Malekahmadi, M | 1 |
| Sedaghat, A | 2 |
| Rostami, A | 1 |
| Alkadir, OKA | 1 |
| Taifi, A | 1 |
| Ranjbar, G | 1 |
| Sahebkar, A | 1 |
| Abdelbasset, WK | 1 |
| Beigmohammadi, MT | 1 |
| Mir, M | 1 |
| Bagheri Moghaddam, A | 2 |
| Tabesh, H | 1 |
| Sadeghi, O | 1 |
| Gholizadeh Navashenaq, J | 2 |
| Firouzi, S | 1 |
| Fathi Najafi, M | 1 |
| Safarian, M | 2 |
| Ghayour-Mobarhan, M | 2 |
| Gaun, S | 1 |
| Ali, SA | 1 |
| Singh, P | 2 |
| Patwa, J | 1 |
| Flora, SJS | 1 |
| Datusalia, AK | 1 |
| Miguel, FM | 2 |
| Picada, JN | 2 |
| da Silva, JB | 1 |
| Schemitt, EG | 1 |
| Colares, JR | 2 |
| Hartmann, RM | 1 |
| Marroni, CA | 2 |
| Marroni, NP | 2 |
| Kholghi, G | 1 |
| Eskandari, M | 1 |
| Shokouhi Qare Saadlou, MS | 1 |
| Zarrindast, MR | 1 |
| Vaseghi, S | 1 |
| Abdollahzade, N | 2 |
| Mihanfar, A | 1 |
| Majidinia, M | 3 |
| Zhang, B | 3 |
| Chen, T | 3 |
| Cao, M | 1 |
| Yuan, C | 1 |
| Zhao, Z | 2 |
| Zhao, Y | 6 |
| Chen, L | 5 |
| Fan, W | 1 |
| Wang, X | 7 |
| Zhou, X | 2 |
| Li, C | 4 |
| Liu, S | 4 |
| Kang, W | 1 |
| Mao, X | 1 |
| Ge, L | 1 |
| Du, H | 1 |
| Li, J | 7 |
| Hou, L | 2 |
| Yin, Y | 1 |
| Liu, Y | 9 |
| Huang, K | 1 |
| Chattree, V | 1 |
| Singh, K | 2 |
| Goel, A | 1 |
| Maity, A | 1 |
| Lone, A | 1 |
| Arabacı Tamer, S | 2 |
| Altınoluk, T | 1 |
| Emran, M | 1 |
| Korkmaz, S | 1 |
| Yüksel, RG | 1 |
| Baykal, Z | 1 |
| Dur, ZS | 1 |
| Levent, HN | 1 |
| Ural, MA | 1 |
| Yüksel, M | 2 |
| Çevik, Ö | 1 |
| Ercan, F | 3 |
| Yıldırım, A | 2 |
| Yeğen, BÇ | 5 |
| Tarakcioglu, E | 1 |
| Tastan, B | 1 |
| Arioz, BI | 1 |
| Tufekci, KU | 1 |
| Genc, S | 1 |
| Ke, C | 1 |
| Li, H | 7 |
| Yang, D | 2 |
| Ying, H | 1 |
| Zhu, H | 4 |
| Xu, J | 4 |
| Wang, L | 9 |
| Tang, H | 3 |
| Yang, M | 5 |
| Zhu, X | 2 |
| Liu, H | 7 |
| Sun, L | 2 |
| Song, P | 1 |
| Dündar, G | 1 |
| Günaydın, Ö | 1 |
| Yazıcı, G | 1 |
| Kurtulan, O | 1 |
| Öğüş, E | 1 |
| Şahin, İ | 1 |
| Al-Shawadfy, MG | 1 |
| Kamel, GAM | 1 |
| Abd-Allah, ARA | 1 |
| Ge, W | 1 |
| Duan, H | 2 |
| Zeng, J | 2 |
| Zhao, X | 6 |
| Hu, J | 2 |
| Jiang, W | 2 |
| Liu, J | 4 |
| Yang, W | 3 |
| Wang, H | 11 |
| Huang, H | 2 |
| Qu, Z | 1 |
| Ma, D | 1 |
| Dang, X | 1 |
| Dong, Q | 1 |
| Moniruzzaman, M | 1 |
| Maiti, AK | 1 |
| Chakraborty, SB | 1 |
| Saha, I | 1 |
| Saha, NC | 1 |
| Li, Y | 16 |
| Hung, SW | 1 |
| Zhang, R | 4 |
| Man, GC | 1 |
| Zhang, T | 3 |
| Chung, JP | 1 |
| Fang, L | 1 |
| Wang, CC | 2 |
| Xu, L | 1 |
| Zhang, O | 1 |
| Zhang, F | 1 |
| Song, M | 1 |
| Ma, M | 1 |
| Ding, R | 1 |
| Li, D | 1 |
| Dong, Z | 1 |
| Jin, S | 2 |
| Han, W | 1 |
| Ding, C | 1 |
| Chowdhury, O | 1 |
| Ghosh, S | 2 |
| Das, A | 3 |
| Shang, P | 1 |
| Stepicheva, NA | 1 |
| Hose, S | 1 |
| Sinha, D | 1 |
| Chattopadhyay, S | 2 |
| Perez, F | 3 |
| Kotecha, N | 3 |
| Lavoie, B | 3 |
| Mawe, GM | 3 |
| Patel, BA | 3 |
| Ajackson, M | 2 |
| Nagagata, BA | 2 |
| Marcondes-de-Castro, IA | 2 |
| Mandarim-de-Lacerda, CA | 2 |
| Aguila, MB | 2 |
| Arinno, A | 2 |
| Maneechote, C | 2 |
| Khuanjing, T | 2 |
| Prathumsap, N | 2 |
| Chunchai, T | 2 |
| Arunsak, B | 2 |
| Nawara, W | 2 |
| Kerdphoo, S | 2 |
| Shinlapawittayatorn, K | 2 |
| Chattipakorn, SC | 2 |
| Chattipakorn, N | 2 |
| Vaghari-Tabari, M | 1 |
| Moein, S | 1 |
| Alipourian, A | 1 |
| Qujeq, D | 1 |
| Malakoti, F | 1 |
| Alemi, F | 1 |
| Yousefi, B | 3 |
| Khazaie, S | 1 |
| Yilmaz, S | 2 |
| Doğanyiğit, Z | 1 |
| Oflamaz, AO | 1 |
| Ateş, Ş | 1 |
| Uçar, S | 1 |
| Söylemez, ESA | 1 |
| Gao, Z | 2 |
| Zheng, Y | 1 |
| Kou, J | 1 |
| Song, D | 1 |
| Yu, X | 4 |
| Dong, B | 1 |
| Yang, Y | 6 |
| Wang, Q | 1 |
| Ye, T | 1 |
| Zhang, X | 7 |
| Yang, L | 3 |
| Sharifi, M | 1 |
| Rajabpoor Nikoo, N | 1 |
| Badehnoosh, B | 1 |
| Shafabakhsh, R | 3 |
| Asemi, R | 1 |
| Asemi, Z | 5 |
| Ozturk, I | 1 |
| Gao, Y | 3 |
| Cheng, Y | 3 |
| Wu, Y | 5 |
| Gu, Z | 1 |
| Cai, L | 2 |
| Gao, C | 1 |
| Li, L | 5 |
| Li, Q | 2 |
| Wang, Y | 12 |
| Wang, F | 3 |
| Luo, C | 1 |
| Tao, L | 1 |
| Gong, MJ | 1 |
| Zhang, HB | 1 |
| Lou, M | 1 |
| Wang, YS | 2 |
| Ma, RP | 1 |
| Hu, ZZ | 1 |
| Zheng, GX | 1 |
| Nabih, HK | 1 |
| Hamed, AR | 1 |
| Yahya, SMM | 1 |
| Kaur, T | 1 |
| Huang, AC | 1 |
| Shyu, BC | 1 |
| Thangwong, P | 1 |
| Jearjaroen, P | 1 |
| Zhang, L | 6 |
| Xiao, F | 1 |
| Wu, L | 2 |
| Guo, Y | 1 |
| Zhang, Z | 3 |
| Xiao, Y | 1 |
| Sun, G | 3 |
| Yang, Q | 2 |
| Guo, H | 1 |
| Lou, Q | 1 |
| Pan, L | 2 |
| Xiang, S | 1 |
| Jin, J | 1 |
| Tan, J | 2 |
| Huang, B | 1 |
| Nan, K | 1 |
| Lin, S | 3 |
| Üstündağ, H | 2 |
| Demir, Ö | 2 |
| Çiçek, B | 1 |
| Huyut, MT | 2 |
| Yüce, N | 1 |
| Tavacı, T | 1 |
| Sarkar, S | 1 |
| Mitra, A | 1 |
| Bandyopadhyay, D | 1 |
| Li, F | 1 |
| Lai, J | 1 |
| Ma, F | 1 |
| Cai, Y | 1 |
| Li, S | 4 |
| Feng, Z | 2 |
| Lu, Z | 1 |
| Liu, X | 7 |
| Ke, Q | 1 |
| Hao, H | 1 |
| Xiao, X | 1 |
| Doğanay, S | 1 |
| Kalındemirtaş, FD | 1 |
| Kurt, N | 2 |
| Özgeriş, FB | 1 |
| Akbaba, Ö | 1 |
| Cui, Y | 2 |
| Hong, S | 2 |
| Xia, Y | 2 |
| Li, X | 9 |
| He, X | 1 |
| Lin, K | 1 |
| Mao, L | 1 |
| Yi, X | 2 |
| Cai, R | 1 |
| Shaoyong, W | 1 |
| Yan, W | 1 |
| He, Z | 1 |
| Li, R | 1 |
| Chao, M | 2 |
| Zhao, T | 3 |
| Deng, L | 2 |
| Yang, G | 1 |
| Pang, W | 1 |
| Yoon, SL | 1 |
| Grundmann, O | 1 |
| Gao, WT | 1 |
| Liu, JX | 1 |
| Wang, DH | 1 |
| Sun, HJ | 1 |
| Zhang, XY | 1 |
| Liu, C | 9 |
| Deng, P | 1 |
| Cheng, J | 3 |
| Yu, Z | 3 |
| Pi, H | 1 |
| Zhou, Z | 3 |
| Hu, H | 3 |
| Ling, J | 1 |
| Yu, S | 2 |
| Xiong, F | 1 |
| Xu, T | 2 |
| Farid, A | 1 |
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| Safwat, G | 1 |
| Yang, Z | 2 |
| He, Y | 2 |
| Ma, Q | 2 |
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| Nematy, M | 1 |
| Stacchiotti, A | 5 |
| Grossi, I | 1 |
| García-Gómez, R | 1 |
| Patel, GA | 1 |
| Salvi, A | 1 |
| Lavazza, A | 2 |
| De Petro, G | 1 |
| Monsalve, M | 1 |
| Rezzani, R | 8 |
| Lin, KC | 1 |
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| Chen, YL | 2 |
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| Mirkovic, MV | 1 |
| Toskic, DR | 1 |
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| Zarezadeh, M | 1 |
| Khorshidi, M | 1 |
| Emami, M | 1 |
| Janmohammadi, P | 1 |
| Kord-Varkaneh, H | 1 |
| Mousavi, SM | 1 |
| Mohammed, SH | 1 |
| Saedisomeolia, A | 1 |
| Alizadeh, S | 1 |
| Anderson, G | 6 |
| Rodriguez, M | 1 |
| Wu, HM | 2 |
| Xie, QM | 2 |
| Zhao, CC | 2 |
| Fan, XY | 1 |
| Fei, GH | 2 |
| Shin, NR | 3 |
| Ko, JW | 1 |
| Kim, JC | 3 |
| Park, G | 1 |
| Kim, SH | 2 |
| Kim, MS | 1 |
| Kim, JS | 3 |
| Shin, IS | 3 |
| He, F | 3 |
| Chen, Z | 2 |
| Su, Q | 1 |
| Yan, M | 1 |
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| Han, Y | 1 |
| Sundberg, I | 1 |
| Rasmusson, AJ | 1 |
| Ramklint, M | 1 |
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| Cunningham, JL | 1 |
| Cheikh, M | 1 |
| Makhlouf, K | 1 |
| Ghattassi, K | 1 |
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| Kallel, C | 2 |
| Houda, M | 1 |
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| Hammouda, O | 2 |
| Vašíček, O | 1 |
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| Číž, M | 1 |
| Bao, Y | 2 |
| Chen, W | 1 |
| Maes, M | 3 |
| Vallée, A | 1 |
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| Guillevin, R | 1 |
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| Maher, AM | 1 |
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| Mukda, S | 3 |
| Chetsawang, B | 1 |
| Tu, Y | 1 |
| Zhu, M | 1 |
| Wang, K | 3 |
| Liu, W | 3 |
| Shi, Q | 2 |
| Zhao, Q | 4 |
| Sun, Y | 4 |
| Song, E | 2 |
| Ali, T | 2 |
| Rahman, SU | 1 |
| Hao, Q | 1 |
| Li, W | 1 |
| Liu, Z | 4 |
| Ali Shah, F | 1 |
| Murtaza, I | 1 |
| Yang, X | 4 |
| Liu, G | 3 |
| Inserra, F | 1 |
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| Sadeghi, H | 1 |
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| Shekarchi, B | 1 |
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| Riviere, E | 1 |
| Rossi, SP | 1 |
| Tavalieri, YE | 1 |
| Muñoz de Toro, MM | 1 |
| Ponzio, R | 1 |
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| Levalle, O | 1 |
| Martinez, G | 1 |
| Terradas, C | 1 |
| Calandra, RS | 1 |
| Matzkin, ME | 1 |
| Frungieri, MB | 1 |
| Zhang, H | 7 |
| Wu, J | 3 |
| Lv, X | 1 |
| Han, S | 1 |
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| Lee, JY | 4 |
| Na, Q | 2 |
| Shin, NE | 3 |
| Shin, HE | 1 |
| Kang, Y | 1 |
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| Lei, J | 3 |
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| Yan, X | 3 |
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| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
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| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts.[NCT04353128] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2020-04-20 | Completed | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| Randomized Controlled Trial of High Dose of Vitamin D as Compared With Placebo to Prevent Complications Among COVID-19 Patients[NCT04411446] | Phase 4 | 218 participants (Actual) | Interventional | 2020-08-11 | Completed | ||
| Association of Anesthesia Technique With Morbidity and Mortality in Patients With COVID-19 and Surgery for Hip Fracture: a Retrospective Population Cohort Study[NCT05133648] | 1,000 participants (Anticipated) | Observational | 2023-01-05 | Active, not recruiting | |||
| Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit[NCT03659760] | 40 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | |||
| Effects of Melatonin on Progression of Coronary Artery Calcification[NCT03966235] | Phase 4 | 74 participants (Anticipated) | Interventional | 2019-06-01 | Recruiting | ||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| Melatonin and Essential Arterial Hypertension[NCT05257291] | Phase 2 | 23 participants (Actual) | Interventional | 2018-02-02 | Active, not recruiting | ||
| A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP)[NCT03764020] | Phase 3 | 320 participants (Anticipated) | Interventional | 2019-06-01 | Not yet recruiting | ||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199] | 14 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478] | Phase 2 | 3 participants (Actual) | Interventional | 2009-01-31 | Terminated | ||
| The Problem of Insulin Resistance in Patients After Carotid Revascularization[NCT03419767] | Phase 4 | 60 participants (Anticipated) | Interventional | 2017-08-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
86 reviews available for melatonin and Inflammation
| Article | Year |
|---|---|
The development of myeloperoxidase inhibitors.
Topics: Animals; Enzyme Inhibitors; Humans; Inflammation; Molecular Structure; Monocytes; Neutrophils; Perox | 2019 |
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Possible Role of Pineal and Extra-Pineal Melatonin in Surveillance, Immunity, and First-Line Defense.
Topics: Animals; Humans; Immunity, Innate; Inflammation; Macrophages; Melatonin; Pineal Gland | 2021 |
Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved.
Topics: Animals; Antioxidants; Arachidonic Acids; Calcium Channel Blockers; Cardiovascular Diseases; Endocan | 2022 |
The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.
Topics: Adipokines; Adipose Tissue, Brown; Humans; Inflammation; Melatonin; Obesity | 2022 |
Melatonin-based therapeutics for atherosclerotic lesions and beyond: Focusing on macrophage mitophagy.
Topics: Animals; Atherosclerosis; Drug Therapy, Combination; Humans; Inflammation; Macrophages; Melatonin; M | 2022 |
Mechanisms of Melatonin in Obesity: A Review.
Topics: Adipose Tissue; Animals; Circadian Rhythm; Gastrointestinal Microbiome; Humans; Inflammation; Lipid | 2021 |
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Type 2; Humans; Inflam | 2022 |
Night shift hormone: How does melatonin affect depression?
Topics: Animals; Antidepressive Agents; Depression; Humans; Inflammation; Melatonin; Serotonin | 2022 |
A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID-19 patients by phytotherapeutic melatonin and epigallocatechin-3-gallate.
Topics: Antioxidants; Antiviral Agents; COVID-19; Humans; Immune System; Inflammation; Melatonin; SARS-CoV-2 | 2022 |
Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight.
Topics: Animals; Endometriosis; Female; Humans; Inflammation; Mammals; Melatonin; Pineal Gland; Receptors, M | 2022 |
Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application.
Topics: Animals; Bacteria; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Melaton | 2023 |
Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Endometriosis; Female; Humans; Inflammation; Melato | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia.
Topics: Cachexia; Dietary Supplements; Fatty Acids, Omega-3; Fish Oils; Gastrointestinal Neoplasms; Humans; | 2023 |
Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation.
Topics: Animals; Bacteria; Circadian Rhythm; Humans; Immunity, Mucosal; Inflammation; Intestines; Melatonin; | 2020 |
Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials.
Topics: Biomarkers; C-Reactive Protein; Dietary Supplements; Humans; Inflammation; Inflammation Mediators; I | 2020 |
Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells.
Topics: Animals; Butyrates; Ceramides; Chronobiology Disorders; Gastrointestinal Microbiome; Humans; Immunit | 2019 |
Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications.
Topics: Butyric Acid; Cell Line; Dysbiosis; Gastrointestinal Microbiome; Homeostasis; Humans; Immune System; | 2020 |
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease.
Topics: Brain; Circadian Rhythm; Humans; Inflammation; Melatonin; Oxidative Stress; Parkinson Disease | 2020 |
Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases.
Topics: Animals; Cannabinoids; Humans; Inflammation; Melatonin; Mitochondria; Neurodegenerative Diseases | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment.
Topics: Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; In | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Ischemic stroke, obesity, and the anti-inflammatory role of melatonin.
Topics: Animals; Anti-Inflammatory Agents; Encephalitis; Humans; Inflammation; Ischemic Stroke; Melatonin; M | 2021 |
Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials.
Topics: Aged; Animals; Anti-Inflammatory Agents; C-Reactive Protein; Dietary Supplements; Humans; Inflammati | 2021 |
Melatonin for the prevention of fetal injury associated with intrauterine inflammation.
Topics: Animals; Anti-Inflammatory Agents; Brain Injuries; Bronchopulmonary Dysplasia; Female; Fetal Disease | 2021 |
Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc.
Topics: Ascorbic Acid; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Humans; I | 2021 |
Possible benefits of exogenous melatonin for individuals on dialysis: a narrative review on potential mechanisms and clinical implications.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Humans; Inflammation; Melatonin; Oxidative Stress; | 2021 |
Melatonin and Microglia.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Humans; Inflammation; Melatonin; Microglia; Recover | 2021 |
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition.
Topics: Cognition; Cognitive Dysfunction; Depressive Disorder, Major; DNA Repair; Humans; Inflammation; Mela | 2018 |
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Circadian Clocks; Dopamine; Dopaminergic Neurons; Genetic Predisposition t | 2017 |
Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes.
Topics: Animals; Humans; Immunity, Innate; Inflammation; Melatonin; Neoplasms; Phagocytes; Pineal Gland | 2018 |
Geroprotectors as a therapeutic strategy for COPD - where are we now?
Topics: Aging; Disease Progression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Me | 2017 |
Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress.
Topics: Apoptosis; Autophagy; Cell Survival; Diabetes Complications; Diabetic Retinopathy; Humans; Inflammat | 2018 |
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases.
Topics: Alzheimer Disease; Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug | 2018 |
The multiple functions of melatonin in regenerative medicine.
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Humans; Inflammation; Melatonin; Regeneration; Regen | 2018 |
Role of Melatonin in the Inflammatory Process and its Therapeutic Potential.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Melatonin; Molecular Structure | 2018 |
Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Pressure; Humans; Hypertension; Inflammation; | 2018 |
Anti-inflammatory effects of Melatonin: A mechanistic review.
Topics: Animals; Anti-Inflammatory Agents; Cardiovascular System; Chronic Disease; Clinical Trials as Topic; | 2019 |
The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.
Topics: Biomarkers; C-Reactive Protein; Dietary Supplements; Humans; Inflammation; Interleukin-6; Melatonin; | 2018 |
The protective role of melatonin in chemotherapy-induced nephrotoxicity: a systematic review of non-clinical studies.
Topics: Animals; Antineoplastic Agents; Apoptosis; Humans; Inflammation; Kidney Diseases; Melatonin; Neoplas | 2018 |
Melatonin and inflammation-Story of a double-edged blade.
Topics: Animals; Humans; Inflammation; Melatonin; NF-E2-Related Factor 2; Signal Transduction; Sirtuin 1 | 2018 |
Melatonin, a toll-like receptor inhibitor: Current status and future perspectives.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immune System Diseases; Inflammation; Melatonin; Myeloid | 2019 |
Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks.
Topics: Aging; Animals; Biomarkers; Cytokines; Disease Susceptibility; Gene Expression Regulation; Gene Regu | 2019 |
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.
Topics: Autophagy; Blood-Brain Barrier; Cell Death; Female; Free Radical Scavengers; Humans; Infant, Newborn | 2019 |
Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms.
Topics: Breast Neoplasms; Female; Humans; Inflammation; Melatonin; Oxidative Stress; Signal Transduction | 2019 |
Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; Humans; Inflammation; Melatoni | 2019 |
NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants.
Topics: Animals; Ecotoxicology; Environmental Pollutants; Humans; Inflammasomes; Inflammation; Interleukin-1 | 2019 |
[Advances in the role of melatonin in infectious diseases: A review].
Topics: Communicable Diseases; Cytokines; Humans; Immune System; Inflammation; Melatonin | 2019 |
Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Clinical Trials as Topic; Disease Models, Animal; Humans; Inflammation | 2013 |
Management of the aging risk factor for Parkinson's disease.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb | 2014 |
Melatonin and its atheroprotective effects: a review.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Gene Expression Regulation; Humans | 2014 |
[Anti-inflammatory potential of melatonin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Synergism; Humans; Inflammation; Melatonin | 2013 |
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
Topics: Carcinogenesis; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Indoles; Inflammat | 2014 |
Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Circadian Clocks; Circadian Rhythm; Circadian Rhythm Signaling Pepti | 2014 |
Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders.
Topics: Humans; Inflammation; Melatonin; Mental Disorders; Neurodegenerative Diseases; Serotonin | 2014 |
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Topics: Aging; Animals; Autophagy; Brain; Caloric Restriction; Circadian Rhythm; Diabetes Mellitus; Energy M | 2014 |
Protective actions of melatonin and growth hormone on the aged cardiovascular system.
Topics: Aging; Animals; Antioxidants; Apoptosis; Cardiovascular Diseases; Cardiovascular System; Growth Horm | 2014 |
Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases.
Topics: Animals; Antioxidants; Caloric Restriction; Humans; Inflammation; Longevity; Melatonin; Resveratrol; | 2015 |
Evaluating the Oxidative Stress in Inflammation: Role of Melatonin.
Topics: Animals; Chronic Disease; Humans; Inflammation; Melatonin; Neoplasms; Oral Health; Oxidative Stress | 2015 |
The potential physiological crosstalk and interrelationship between two sovereign endogenous amines, melatonin and homocysteine.
Topics: Amines; Animals; Antioxidants; Biosynthetic Pathways; Homocysteine; Humans; Hyperhomocysteinemia; In | 2015 |
Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.
Topics: Animals; Chromosomes, Human, Pair 4; Epigenesis, Genetic; Glioma; Humans; Inflammation; Melatonin; M | 2016 |
Avian biological clock - Immune system relationship.
Topics: Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Avian Proteins; Biological | 2017 |
Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways.
Topics: Depression; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Intestines; Melato | 2016 |
Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells.
Topics: Animals; Cytokines; Humans; Immune System; Inflammation; Melatonin; Monocytes; Neutrophils; Pineal G | 2016 |
Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain.
Topics: Acetamides; Analgesics; Aniline Compounds; Animals; Brain; Clinical Studies as Topic; Humans; Inflam | 2018 |
Melatonin as an anti-inflammatory agent in radiotherapy.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Humans; Inflammation; Melatonin; Mucositis; Neoplasms | 2017 |
Topical non-barrier agents for postoperative adhesion prevention in animal models.
Topics: Acetamides; Antioxidants; Collagen Type I; Female; Fibrin; Glucans; Glucose; Honey; Humans; Hydroxym | 2010 |
Melatonin in septic shock: some recent concepts.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni | 2010 |
Melatonin: a pleiotropic molecule regulating inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Arachidonic Acid; Cell Survival; Humans; | 2010 |
Neuroinflammation and ageing: current theories and an overview of the data.
Topics: Aging; Alzheimer Disease; Apoptosis; Atherosclerosis; Biological Evolution; Brain; Cellular Senescen | 2011 |
Mitochondrial DNA and inflammatory diseases.
Topics: Autoimmune Diseases; Carrier Proteins; DNA, Mitochondrial; Humans; Immunity, Innate; Inflammation; M | 2012 |
Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Diabetes Mellitus, Type | 2012 |
Gene regulation by melatonin linked to epigenetic phenomena.
Topics: Animals; Anti-Inflammatory Agents; Cricetinae; Epigenesis, Genetic; Humans; Inflammation; Melatonin; | 2012 |
Potential therapeutic effect of antioxidant therapy in shock and inflammation.
Topics: Animals; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Inflammation; Melatonin; Oxidat | 2004 |
Retardation of brain aging by chronic treatment with melatonin.
Topics: Aging; Animals; Brain; Cytokines; Gene Expression Regulation; Humans; Inflammation; Melatonin; Neuro | 2004 |
Melatonin and Parkinson's disease.
Topics: Animals; Apoptosis; Free Radical Scavengers; Free Radicals; Humans; Inflammation; Melatonin; Mitocho | 2005 |
The modulatory role of melatonin on immune responsiveness.
Topics: Adjuvants, Immunologic; Animals; Autoimmune Diseases; B-Lymphocytes; Clinical Trials as Topic; Cytok | 2006 |
Melatonin role in the mitochondrial function.
Topics: Animals; Humans; Inflammation; Melatonin; Mitochondria; Mitochondrial Diseases; Neurodegenerative Di | 2007 |
Melatonin and its role in oxidative stress related diseases of oral cavity.
Topics: Antioxidants; Humans; Inflammation; Melatonin; Mouth Diseases; Oxidative Stress; Periodontal Disease | 2007 |
Melatonin and its influence on immune system.
Topics: Gastrointestinal Tract; Humans; Immune System; Inflammation; Melatonin; Pineal Gland; Retina | 2007 |
Influence of melatonin and its precursor L-tryptophan on Th1 dependent contact hypersensitivity.
Topics: Animals; Dermatitis, Contact; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-12; Interl | 2007 |
Melatonin and its relation to the immune system and inflammation.
Topics: Animals; Humans; Immunity; Inflammation; Melatonin; Neuroimmunomodulation | 2000 |
Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.
Topics: Animals; Free Radical Scavengers; Humans; Inflammation; Melatonin; Models, Biological; Poly(ADP-ribo | 2001 |
Pharmacological actions of melatonin in acute and chronic inflammation.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Inflammation; Melatonin; Oxidants; Oxidative Stress | 2002 |
16 trials available for melatonin and Inflammation
| Article | Year |
|---|---|
Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial.
Topics: Biomarkers; Dietary Supplements; Double-Blind Method; Humans; Inflammation; Melatonin; Oxidative Str | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies.
Topics: Adolescent; Adult; Aged; Biomarkers; Dose-Response Relationship, Drug; Female; Humans; Inflammation; | 2019 |
Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes.
Topics: Adolescent; Athletes; Circadian Rhythm; Double-Blind Method; Eating; Humans; Inflammation; Male; Mel | 2020 |
Prospective Randomized Study on the Effects of Improved Sleep Quality After Craniotomy on Melatonin Concentrations and Inflammatory Response in Neurosurgical Intensive Care Patients.
Topics: Adult; Aged; C-Reactive Protein; Craniotomy; Critical Care; Ear Protective Devices; Eye Protective D | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.
Topics: Adult; Antioxidants; Cross-Over Studies; Double-Blind Method; Exercise; Female; Humans; Immunity; In | 2021 |
The Effect of Melatonin on Periodontitis.
Topics: Animals; Antioxidants; Biomarkers; Disease Models, Animal; Humans; Inflammation; Male; Melatonin; Mi | 2021 |
Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adolescent; Adult; Biomarkers; Dietary Supplements; Double-Blind Method; Female; Humans; Inflammatio | 2022 |
Melatonin Improves Erythropoietin Hyporesponsiveness via Suppression of Inflammation.
Topics: Anemia; Antioxidants; Biomarkers; Erythropoietin; Female; Hematinics; Humans; Inflammation; Male; Me | 2019 |
A double-blind, placebo-controlled trial related to the effects of melatonin on oxidative stress and inflammatory parameters of obese women.
Topics: Adult; C-Reactive Protein; Double-Blind Method; Female; Humans; Inflammation; Insulin Resistance; In | 2015 |
Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain.
Topics: Analysis of Variance; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Central Nervous Syst | 2015 |
Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Cross-Over Studies; Dose-Response Relatio | 2015 |
No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ascorbic Aci | 2010 |
Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; Dietary Supplements; Exercise; Humans; Inflammation; In | 2011 |
Utility of melatonin to treat surgical stress after major vascular surgery--a safety study.
Topics: Aged; Antioxidants; Aortic Aneurysm, Abdominal; Biomarkers; Female; Hemodynamics; Humans; Inflammati | 2008 |
276 other studies available for melatonin and Inflammation
| Article | Year |
|---|---|
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capillary Permeability; Free Radical | 2010 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Melatonin derivatives combat with inflammation-related cancer by targeting the Main Culprit STAT3.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relation | 2021 |
Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cytokines; Inflammation; Melatonin; Mice; Neurona | 2021 |
Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Polarity; Citrates; Ethylene Dich | 2021 |
Melatonin attenuates reactive astrogliosis and glial scar formation following cerebral ischemia and reperfusion injury mediated by GSK-3β and RIP1K.
Topics: Animals; Brain Ischemia; Gliosis; Glycogen Synthase Kinase 3 beta; Inflammation; Male; Melatonin; Ne | 2022 |
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy.
Topics: Apoptosis; Autophagy; Humans; Inflammation; Intervertebral Disc; Intervertebral Disc Degeneration; M | 2022 |
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Gout; Inflammation; Melatonin; Ox | 2022 |
Melatonin ameliorates chronic copper-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Copper; Female; Inflammation; Lung; Lung Injury; Me | 2023 |
Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2022 |
Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains.
Topics: Animals; Arsenic; Brain; Inflammation; Melatonin; Rats; Rats, Wistar; Rodent Diseases | 2022 |
Gut Microbiota Dysbiosis Induced by Decreasing Endogenous Melatonin Mediates the Pathogenesis of Alzheimer's Disease and Obesity.
Topics: Alzheimer Disease; Animals; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Melatonin; Mice; O | 2022 |
Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice.
Topics: Aflatoxin B1; Animals; Chemical and Drug Induced Liver Injury, Chronic; Gastrointestinal Microbiome; | 2022 |
Melatonin Alleviates Ovariectomy-Induced Cardiovascular Inflammation in Sedentary or Exercised Rats by Upregulating SIRT1.
Topics: Animals; Cardiovascular System; Female; Hormone Replacement Therapy; Inflammation; Melatonin; Ovarie | 2022 |
Melatonin Alters the miRNA Transcriptome of Inflammasome Activation in Murine Microglial Cells.
Topics: Adenosine Triphosphate; Animals; Inflammasomes; Inflammation; Lipopolysaccharides; Melatonin; Mice; | 2022 |
Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage.
Topics: Animals; Cartilage, Articular; Cyclooxygenase 2; Inflammation; Interleukin-6; Knee Joint; Male; Mela | 2022 |
Melatonin alleviates renal injury by activating mitophagy in diabetic nephropathy.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus; Diabetic Nephropathies; Inflammation; Kid | 2022 |
Investigation of the protective effects of intraperitoneal melatonin in rats receiving laryngeal radiotherapy.
Topics: Animals; Antioxidants; Inflammation; Melatonin; Oxidative Stress; Rats; Rats, Wistar | 2023 |
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Biomarkers; Contrast Media; Inflammasomes; Infla | 2022 |
Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro.
Topics: Animals; Epithelial Cells; Female; Inflammation; Lipopolysaccharides; Melatonin; Phosphatidylinosito | 2022 |
Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Apoptosis; Humans; Inflammation; Klebsiella Infections; Klebsiella pn | 2022 |
Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome.
Topics: Animals; Antioxidants; DNA Nucleotidylexotransferase; Glutathione Peroxidase; Inflammasomes; Inflamm | 2022 |
Melatonin ameliorates lipopolysaccharide induced brain inflammation through modulation of oxidative status and diminution of cytokine rush in Danio rerio.
Topics: Animals; Cytokines; Encephalitis; Inflammation; Lipopolysaccharides; Melatonin; NF-E2-Related Factor | 2022 |
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis | 2023 |
Sustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin.
Topics: Animals; Autophagy; Epithelial-Mesenchymal Transition; Hepatocytes; Inflammation; Liver; Liver Cirrh | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Topics: Animals; Epithelium; Inflammation; Intestinal Mucosa; Melatonin; Mice; Serotonin | 2023 |
Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Endoplasmic Reticulum S | 2023 |
Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Endoplasmic Reticulum S | 2023 |
Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Endoplasmic Reticulum S | 2023 |
Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Endoplasmic Reticulum S | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway.
Topics: Animals; Inflammation; Interleukin-6; Lipopolysaccharides; Melatonin; NF-kappa B; Nuclear Proteins; | 2023 |
Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Autophagy; Down-Regulation; Galectin 3; Inflammation; M | 2023 |
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation.
Topics: Acrylamide; Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury | 2023 |
Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Ferritins; Humans; Inflammation; Interleukin-33; Me | 2023 |
Multidrug nanoformulations of vitamin D, anandamide and melatonin as a synergistic treatment for vascular inflammation.
Topics: Antioxidants; Arachidonic Acids; Humans; Inflammation; Melatonin; Vitamin D | 2023 |
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Topics: Cytokines; Epithelial Cells; Humans; Inflammation; Interleukin-33; Melatonin; Nasal Polyps; Reactive | 2023 |
Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro | 2023 |
Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Interleukin-6; Melatonin; Neuralgia; Ne | 2023 |
Melatonin suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway.
Topics: Animals; Blood-Brain Barrier; Dementia, Vascular; Inflammation; Male; Melatonin; PPAR gamma; Rats; R | 2023 |
Melatonin-Driven NLRP3 Inflammation Inhibition Via Regulation of NF-κB Nucleocytoplasmic Transport: Implications for Postoperative Cognitive Dysfunction.
Topics: Active Transport, Cell Nucleus; Animals; Inflammasomes; Inflammation; Melatonin; Mice; NF-kappa B; N | 2023 |
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Topics: Animals; Benzalkonium Compounds; Caspase 1; Dry Eye Syndromes; Epithelium, Corneal; Inflammation; Li | 2023 |
Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study.
Topics: Animals; Antioxidants; Ascorbic Acid; Glutathione; Inflammation; Lung; Lung Injury; Melatonin; Oxida | 2023 |
An integrated strategy to explore the potential role of melatonin against copper-induced adrenaline toxicity in rat cardiomyocytes: Insights into oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Copper; Epinephrine; Hydrogen Peroxide; Inflammation; Melatonin; M | 2023 |
Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life.
Topics: Animals; Butyric Acid; Dietary Supplements; Fatty Acids, Volatile; Female; Gastrointestinal Microbio | 2023 |
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats.
Topics: Animals; Brain Ischemia; Inflammation; Male; Melatonin; Necroptosis; Neuroinflammatory Diseases; Obe | 2023 |
A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats.
Topics: Animals; Ascorbic Acid; Inflammation; Kidney; Male; Melatonin; Rats; Rats, Sprague-Dawley; Sepsis; S | 2023 |
Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy.
Topics: Animals; Endoplasmic Reticulum Stress; Exosomes; Humans; Inflammation; Macrophages; Melatonin; Perio | 2023 |
Melatonin promotes gut anti-oxidative status in perinatal rat by remodeling the gut microbiome.
Topics: Animals; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Inflammation; Mammal | 2023 |
Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus).
Topics: Aging; Animals; Coleoptera; Colon; Energy Metabolism; Gerbillinae; Inflammation; Melatonin; Mice; Ra | 2023 |
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Inflammation; Melatonin; Mice; NF-kappa B | 2023 |
Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy.
Topics: Acute Lung Injury; Animals; Inflammation; Melatonin; Mice; Mice, Inbred C57BL; Mitophagy; Sepsis | 2023 |
Melatonin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat's liver from the hazardous effects of CCL4.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Drug Carriers; Inflammation; Liver; Male | 2023 |
Alleviative effect of melatonin against the nephrotoxicity induced by cadmium exposure through regulating renal oxidative stress, inflammatory reaction, and fibrosis in a mouse model.
Topics: Animals; Cadmium; Drug-Related Side Effects and Adverse Reactions; Fibrosis; Humans; Inflammation; K | 2023 |
The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Caspase 1; Cell Line; Cytokines; Humans; Inflammasomes; In | 2023 |
Melatonin Protects Injured Spinal Cord Neurons From Apoptosis by Inhibiting Mitochondrial Damage via the SIRT1/Drp1 Signaling Pathway.
Topics: Animals; Apoptosis; Dynamins; Inflammation; Melatonin; Mice; Neurons; Rats; Rats, Sprague-Dawley; Si | 2023 |
Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis.
Topics: Animals; Apoptosis; HMGB1 Protein; Hypoxia; Inflammation; Melatonin; MicroRNAs; Myocardial Infarctio | 2023 |
Melatonin alleviates particulate matter-induced liver fibrosis by inhibiting ROS-mediated mitophagy and inflammation via Nrf2 activation.
Topics: Animals; Inflammation; Liver Cirrhosis; Melatonin; Mice; Mitophagy; NF-E2-Related Factor 2; Particul | 2023 |
Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase.
Topics: Animals; Brain Ischemia; Inflammation; Ischemia; Male; Melatonin; Microglia; Neuroimmunomodulation; | 2019 |
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy.
Topics: Animals; Autophagy; Diet, High-Fat; Inflammation; Insulin Resistance; Liver; Male; Melatonin; Mice; | 2019 |
Combined Therapy With Hyperbaric Oxygen and Melatonin Effectively Reduce Brain Infarct Volume and Preserve Neurological Function After Acute Ischemic Infarct in Rat.
Topics: Animals; Apoptosis; Brain; Brain Infarction; Brain Ischemia; Disease Models, Animal; Hyperbaric Oxyg | 2019 |
Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response.
Topics: Acute Lung Injury; Animals; Antioxidants; Arginine; Carbon Tetrachloride; Inflammation; Melatonin; N | 2019 |
Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Female; Hypersensitivity; Inflammasomes; I | 2019 |
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke.
Topics: Acetylation; Animals; Antioxidants; Gene Expression Regulation; Inflammation; Inflammation Mediators | 2020 |
Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.
Topics: Animals; Extracellular Matrix; Female; Humans; Inflammation; Interleukin-1beta; Intervertebral Disc | 2019 |
Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Anxiety Disorders; CD5 Antigens; Chemokine | 2020 |
Serotonin and its metabolites reduce oxidative stress in murine RAW264.7 macrophages and prevent inflammation.
Topics: Animals; Antioxidants; Cytokines; Inflammation; Macrophages; Melatonin; Mice; Nitric Oxide; Oxidativ | 2020 |
Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Inflammation; Male; Melatonin; Mice, Inbred C57BL; Micr | 2020 |
Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Diabetes Mellitus, | 2020 |
Melatonin suppresses ischemia-induced fibrosis by regulating miR-149.
Topics: Animals; Fibrosis; Inflammation; Ischemia; Melatonin; Mice; MicroRNAs; Myoblasts; Peroxisome Prolife | 2020 |
TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation.
Topics: Animals; Asthma; Feedback, Physiological; Female; Inflammasomes; Inflammation; Melatonin; Mice; Mice | 2020 |
Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses.
Topics: Fibroblasts; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; Melatonin; Prostaglandin- | 2020 |
Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis.
Topics: Animals; Butyric Acid; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Disease Models, An | 2020 |
The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin.
Topics: Animals; Antigens; Brain; Central Nervous System Stimulants; Inflammation; Lipopolysaccharides; Male | 2020 |
Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy.
Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus; Diabetic Retinopathy; Ependymoglial Cells; Hypergl | 2020 |
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation.
Topics: Animals; Astrocytes; Autophagy; Depressive Disorder, Major; Forkhead Box Protein O3; Gene Expression | 2020 |
Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice.
Topics: Aeromonadaceae; Animals; Antioxidants; Bacteroidaceae; Dysbiosis; Firmicutes; Gastrointestinal Micro | 2020 |
Mitigation of Radiation-Induced Gastrointestinal System Injury by Melatonin: A Histopathological Study.
Topics: Animals; Apoptosis; Cobalt Radioisotopes; Gastrointestinal Tract; Inflammation; Intestine, Small; Ma | 2020 |
Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology.
Topics: Adult; Antioxidants; Dietary Supplements; Humans; Inflammation; Male; Melatonin; Oxidative Stress; S | 2020 |
Melatonin inhibits the endoplasmic reticulum stress‑induced, C/EBP homologous protein‑mediated pathway in acute pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Inflam | 2020 |
Melatonin pretreatment alleviates renal ischemia-reperfusion injury by promoting autophagic flux via TLR4/MyD88/MEK/ERK/mTORC1 signaling.
Topics: Animals; Autophagy; Extracellular Signal-Regulated MAP Kinases; Female; Inflammation; Kidney; Mechan | 2020 |
Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation.
Topics: Animals; Female; Fetal Diseases; Fetus; Inflammation; Lung; Lung Injury; Melatonin; Mice; Pregnancy | 2020 |
Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway.
Topics: Actins; Animals; Bone Marrow Cells; Catalase; Cathepsin K; Cell Differentiation; Cells, Cultured; In | 2020 |
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats.
Topics: Animals; Central Nervous System Depressants; Dextran Sulfate; Inflammation; Male; Melatonin; Metabol | 2020 |
Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Inflammation; Injections, Intravenous; Janus | 2020 |
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System Stimulants; Cognitive Dysfunction; Hippoca | 2021 |
Topics: Acute Coronary Syndrome; Adolescent; Adsorption; Adult; Aged; Animals; Aspergillus; Aspergillus oryz | 2021 |
Melatonin maintains the function of the blood redox system at combined ethanol-induced toxicity and subclinical inflammation in mice.
Topics: Animals; Ethanol; Inflammation; Lipopolysaccharides; Male; Melatonin; Mice; Mice, Inbred BALB C; Oxi | 2021 |
Melatonin alleviates LPS-induced endoplasmic reticulum stress and inflammation in spermatogonial stem cells.
Topics: Adult Germline Stem Cells; Animals; Apoptosis; Cell Survival; Endoplasmic Reticulum Stress; Inflamma | 2021 |
Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers.
Topics: Adult; Antioxidants; Biomarkers; Case-Control Studies; Egypt; Female; Humans; Hydrocortisone; Inflam | 2021 |
The protective role of melatonin against the effects of different doses of caffeine on the fetus.
Topics: Animals; Antioxidants; Biomarkers; Bone and Bones; Caffeine; Female; Fetus; Inflammation; Liver; Mal | 2020 |
The effects of melatonin against atherosclerosis-induced endothelial dysfunction and inflammation in hypercholesterolemic rats.
Topics: Animals; Atherosclerosis; Atorvastatin; Hypercholesterolemia; Hyperlipidemias; Inflammation; Melaton | 2023 |
Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation.
Topics: Acetylcholinesterase; Animals; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Diabetes Mel | 2021 |
Exosome and Melatonin Additively Attenuates Inflammation by Transferring miR-34a, miR-124, and miR-135b.
Topics: Cell Proliferation; Exosomes; Fibroblasts; Gene Expression Regulation; Humans; Inflammation; Inflamm | 2020 |
Attenuation of chronic arsenic neurotoxicity via melatonin in male offspring of maternal rats exposed to arsenic during conception: Involvement of oxidative DNA damage and inflammatory signaling cascades.
Topics: Animals; Antioxidants; Apoptosis; Arsenic; Female; Inflammation; Male; Melatonin; Neuroprotective Ag | 2021 |
Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function.
Topics: Animals; Antioxidants; Gastrointestinal Microbiome; Inflammation; Liver; Melatonin; Mice; Mitophagy; | 2021 |
Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Connexin 43; Diabetes Mellitus, Experimental; Glutathio | 2021 |
Melatonin alleviates Ochratoxin A-induced liver inflammation involved intestinal microbiota homeostasis and microbiota-independent manner.
Topics: Animals; Antioxidants; Gastrointestinal Microbiome; Homeostasis; Humans; Inflammation; Liver; Melato | 2021 |
Role of melatonin in murine "restraint stress"-induced dysfunction of colonic microbiota.
Topics: Animals; Antioxidants; Bacteria; Colon; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Intest | 2021 |
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Inflammat | 2021 |
Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway.
Topics: Adult; Animals; Antioxidants; Autophagy; Case-Control Studies; Female; Gene Expression Regulation; H | 2021 |
LPS-induced immunomodulation and hormonal variation over time in toads.
Topics: Animals; Blood Bactericidal Activity; Bufonidae; Corticosterone; Immunomodulation; Inflammation; Lip | 2021 |
Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro.
Topics: Acute Disease; Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Interl | 2021 |
Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise.
Topics: Animals; Antioxidants; Inflammation; Liver Cirrhosis; Male; Melatonin; Oxidative Stress; Physical Co | 2021 |
Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats.
Topics: Animals; Antioxidants; Body Weight; Catalase; Chromatography, High Pressure Liquid; Glutathione; Gon | 2021 |
Melatonin protects cochlear hair cells from nicotine-induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Survival; Endoplasmic Reticulum S | 2021 |
A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement.
Topics: Adult; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Female; Humans; I | 2021 |
Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants.
Topics: Caco-2 Cells; Cytokines; Gene Silencing; Humans; Inflammation; Inflammatory Bowel Diseases; Intestin | 2021 |
Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice.
Topics: Animals; Inflammation; Jejunum; Lipopolysaccharides; Melatonin; Mice; Tryptamines | 2021 |
Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats.
Topics: Adherens Junctions; Animals; Animals, Newborn; Blood-Brain Barrier; Brain Injuries; Disease Models, | 2017 |
Melatonin reduces changes to small intestinal microvasculature during systemic inflammation.
Topics: Animals; Inflammation; Injections, Intravenous; Intestine, Small; Lipopolysaccharides; Male; Melaton | 2017 |
Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats.
Topics: Animals; Antioxidants; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Inflammation; Lung; Melato | 2017 |
The effect of melatonin on gene expression of calcitonin gene-related peptide and some proinflammatory mediators in patients with pure menstrual migraine.
Topics: Adult; Anti-Inflammatory Agents; Calcitonin Gene-Related Peptide; Cells, Cultured; Female; Gene Expr | 2017 |
Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial.
Topics: Animals; Endotoxemia; Inflammation; Lipopolysaccharides; Male; Melatonin; Rats; Rats, Wistar; Sepsis | 2017 |
High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation.
Topics: alpha 1-Antitrypsin; Animals; Biomarkers; Blood Glucose; Blood Proteins; Body Weight; Complement C4; | 2017 |
Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Body Weight; Disease Models, Anim | 2017 |
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi | 2017 |
Biological functions of melatonin in relation to pathogenesis of oral lichen planus.
Topics: Animals; Circadian Rhythm; Female; Hormones; Humans; Immune System; Inflammation; Lichen Planus, Ora | 2017 |
Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury.
Topics: Animals; Annexin A5; Antioxidants; Apoptosis; Benzimidazoles; Brain Edema; Brain Injuries; Carbocyan | 2018 |
Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice.
Topics: Animals; Birth Injuries; Brain Injuries; Female; Inflammation; Lipopolysaccharides; Melatonin; Mice; | 2017 |
Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients.
Topics: Adult; Antioxidants; Cells, Cultured; Female; Humans; Inflammation; Male; Melatonin; Multiple Sclero | 2017 |
Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain.
Topics: Animals; Astrocytes; Inflammation; Inflammation Mediators; Melatonin; Pain Measurement; Rats; Spinal | 2017 |
Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Inflammation; Male; MAP Kinase Si | 2017 |
Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca
Topics: Adenylate Kinase; Apoptosis; Calcium; Caspase 9; Human Umbilical Vein Endothelial Cells; Humans; Inf | 2018 |
Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit.
Topics: Adolescent; Adult; Aged; C-Reactive Protein; Female; Humans; Inflammation; Inflammation Mediators; I | 2017 |
Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model.
Topics: Animals; Apoptosis; Autoantibodies; Cytokines; Disease Models, Animal; Female; Fibrosis; Inflammatio | 2018 |
Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.
Topics: Adipose Tissue; Adiposity; Animals; Exosomes; Inflammation; Ketoglutaric Acids; Macrophages; Melaton | 2018 |
Does the administration of melatonin during post-traumatic brain injury affect cytokine levels?
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Anim | 2018 |
Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Disease Models, Animal; I-kappa B Kinase; Inflammation; | 2018 |
A complex systems approach to cancer prevention.
Topics: beta-Glucans; Decision Support Techniques; Diet; Drug Synergism; Energy Metabolism; Exercise; Glucos | 2018 |
Melatonin provides protection against heat stroke-induced myocardial injury in male rats.
Topics: Animals; Cardiotonic Agents; Heat Stroke; Inflammation; Male; Melatonin; Myocardial Infarction; Oxid | 2018 |
Attenuating effect of melatonin on lipopolysaccharide-induced chicken small intestine inflammation.
Topics: Animal Feed; Animals; Animals, Newborn; Apoptosis; Avian Proteins; Cell Proliferation; Chickens; Die | 2018 |
Histomorphological changes in the pancreas and kidney and histopathological changes in the liver in male Wistar rats on antiretroviral therapy and melatonin treatment.
Topics: Animals; Anti-Retroviral Agents; Disease Models, Animal; Drug Therapy, Combination; HIV; Immunohisto | 2018 |
Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice.
Topics: Animals; Arsenic; Inflammation; Kidney Diseases; Melatonin; Mice; Oxidative Stress; Signal Transduct | 2018 |
3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration.
Topics: Actins; Animals; Autophagy; Cell Proliferation; Cell Survival; Electrophysiology; Inflammation; Ki-6 | 2018 |
Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform.
Topics: Anti-Inflammatory Agents; Antioxidants; C-Reactive Protein; Cyclic AMP Response Element-Binding Prot | 2018 |
Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder.
Topics: Animals; Anti-Inflammatory Agents; Cognition; Cognitive Dysfunction; Cyclic AMP Response Element-Bin | 2018 |
Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels.
Topics: Animals; Animals, Genetically Modified; Animals, Newborn; Arylalkylamine N-Acetyltransferase; Autoph | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Gene Expression Regulation; G | 2018 |
Melatonin improves quality and longevity of chronic neural recording.
Topics: Animals; Antioxidants; Apoptosis; Gliosis; Inflammation; Male; Melatonin; Mice; Mice, Inbred C57BL; | 2018 |
Responses of Transgenic Melatonin-Enriched Goats on LPS Stimulation and the Proteogenomic Profiles of Their PBMCs.
Topics: Animals; Animals, Genetically Modified; Female; Goats; Inflammation; Leukocytes, Mononuclear; Lipopo | 2018 |
Melatonin: A hypothesis for Kawasaki disease treatment.
Topics: Anti-Inflammatory Agents; Aspirin; Child; Child, Preschool; Communicable Diseases; Genetic Predispos | 2018 |
Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Mel | 2018 |
Effects of nicotine on rat adrenal gland: crosstalk between oxidative and inflammatory markers, and amelioration by melatonin.
Topics: Adrenal Glands; Animals; Antioxidants; Biomarkers; Cytokines; Inflammation; Male; Melatonin; Nicotin | 2019 |
Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions.
Topics: Adult; Antioxidants; Athletes; Humans; Inflammation; Male; Melatonin; Young Adult | 2019 |
Melatonin supports alendronate in preserving bone matrix and prevents gastric inflammation in ovariectomized rats.
Topics: Alendronate; Animals; Bone Matrix; Female; Gastritis; Inflammation; Melatonin; Osteoporosis; Ovariec | 2019 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Melatonin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Cultured Mouse Mammary Tissue.
Topics: Animals; Anti-Inflammatory Agents; Female; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mam | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Measurement of melatonin, indole-dioxygenase, IL-6, IL-18, ferritin, CRP, and total homocysteine levels during herpes zoster.
Topics: Aged; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Ferritins; Herpes Zoster; Herpes | 2020 |
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.
Topics: Animals; Antioxidants; Heart; Heart Transplantation; Inflammation; Janus Kinase 2; Male; Melatonin; | 2019 |
Prophylactic administration of carnosine and melatonin abates the incidence of apoptosis, inflammation, and DNA damage induced by titanium dioxide nanoparticles in rat livers.
Topics: Animals; Antioxidants; Apoptosis; Carnosine; DNA Damage; Glutathione; Incidence; Inflammation; Liver | 2020 |
Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Fetal Diseases; Hemodynamics; Humans; Immun | 2019 |
Oxidative stress, DNA stability and evoked inflammatory signaling in young celiac patients consuming a gluten-free diet.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Antioxidants; Celiac Disease; Child; Diet, Gluten-Free; Din | 2020 |
Melatonin improves the structure and function of autografted mice ovaries through reducing inflammation: A stereological and biochemical analysis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cytokines; Estradiol; Female; Inflammation; Inflammati | 2019 |
Wnt4 signaling mediates protective effects of melatonin on new bone formation in an inflammatory environment.
Topics: Animals; Calcium; Cell Line; Frizzled Receptors; Gene Expression Regulation; Humans; Inflammation; M | 2019 |
The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Colon; Diet, High-Fat; Disease Models, Animal; Dysbios | 2019 |
Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model.
Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Inflammation; Lipopolysaccharides; Melatonin; | 2019 |
Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Hemorrhage; Deubiquitinating Enzymes; Disease Models, A | 2019 |
Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin-1β.
Topics: Caco-2 Cells; Cell Differentiation; Cyclooxygenase 2; DNA Methylation; Epithelial Cells; Humans; Inf | 2019 |
The expression of inflammatory cytokines on the aorta endothelia are up-regulated in pinealectomized rats.
Topics: Animals; Aorta; C-Reactive Protein; Cell Line; Chemokine CCL2; Endothelium, Vascular; Glucose; Infla | 2013 |
Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Circadian Rhythm; Dexamethasone; Freund's Adjuvant; H | 2013 |
The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat.
Topics: Acetic Acid; Animals; Biomarkers; Colitis; Gene Expression Regulation; Inflammation; Male; Melatonin | 2013 |
Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.
Topics: Animals; Antioxidants; Apoptosis; Cell Cycle; Disease Models, Animal; Gene Expression Regulation; In | 2013 |
Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin.
Topics: Acute-Phase Reaction; Animals; Antioxidants; Ascorbic Acid; Circadian Rhythm; Darkness; Disease Mode | 2013 |
Neuropeptide downregulation in sepsis.
Topics: alpha-MSH; Cohort Studies; Down-Regulation; Humans; Hydrocortisone; Inflammation; Melatonin; Neurope | 2014 |
Melatonin ameliorates vascular endothelial dysfunction, inflammation, and atherosclerosis by suppressing the TLR4/NF-κB system in high-fat-fed rabbits.
Topics: Animals; Atherosclerosis; Diet, High-Fat; Inflammation; Male; Melatonin; NF-kappa B; Rabbits; Toll-L | 2013 |
Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway.
Topics: Animals; Blotting, Western; Brain Injuries; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immu | 2013 |
JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells.
Topics: Acetophenones; Animals; Anthracenes; Antioxidants; Cell Line; Cell Survival; Enzyme Inhibitors; Enzy | 2013 |
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi | 2013 |
Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases.
Topics: Cell Survival; Chondrogenesis; Free Radical Scavengers; Gene Expression Regulation, Developmental; H | 2014 |
Immune stimulation by exogenous melatonin during experimental endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Endotoxemia; Inflammation; Lipopolysaccharides; Male; | 2014 |
Protective effect of melatonin on infrarenal aortic occlusion: this effect is related to anti-inflammatory effect and antioxidant effect.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Arterial Occlusive Diseases; Blood Urea Nitr | 2014 |
Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin.
Topics: Administration, Oral; Animals; DNA Damage; Dose-Response Relationship, Drug; Inflammation; Interleuk | 2014 |
Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin.
Topics: Adiponectin; Adipose Tissue; Animals; Antioxidants; Body Weight; Hypoxia; Inflammation; Male; Melato | 2014 |
Anti-inflammatory activities of melatonin derivatives in lipopolysaccharide-stimulated RAW 264.7 cells and antinociceptive effects in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Rela | 2014 |
Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells.
Topics: Diabetes Mellitus; Down-Regulation; Endothelial Cells; Epithelial Cells; Glucose; Humans; Inflammati | 2014 |
Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Injuries; Enzyme-Linked Immunosorbent Assay; Flu | 2014 |
Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis.
Topics: Allografts; Animals; Apoptosis; bcl-2-Associated X Protein; Cyclosporine; Drug Synergism; Graft Surv | 2014 |
Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats.
Topics: Animals; Inflammation; Male; Melatonin; Metabolic Syndrome; Rats; Rats, Wistar | 2014 |
Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats.
Topics: Animals; Apoptosis; Blotting, Western; Cytokines; Dentate Gyrus; Disease Models, Animal; Enzyme-Link | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Cell Proliferation; Hypertension | 2014 |
Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Antioxidants; Cyclooxygenase 2; Hypoxia; Inflammation; Lipid Peroxidation; | 2014 |
Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.
Topics: Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme-Linked Immunosorbent Assay; Extracellular | 2014 |
Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspases; Disease Models, Animal; Hypoxia; Hypoxia | 2015 |
Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2015 |
Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Galactose; Inflammat | 2015 |
Effects of melatonin on the serum levels of pro-inflammatory cytokines and tissue injury after renal ischemia reperfusion in rats.
Topics: Animals; Antioxidants; Biological Factors; Inflammation; Interleukin-6; Kidney; Kidney Diseases; Lip | 2015 |
Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis.
Topics: Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; Inflammation; Lipid Peroxidati | 2015 |
Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cytokines; Disease Models, Animal; Female; Gene Expr | 2015 |
A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Topics: Acute Lung Injury; Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Li | 2015 |
The protective effect of melatonin on neural stem cell against LPS-induced inflammation.
Topics: Cell Differentiation; Gene Expression; Humans; Inflammation; Lipopolysaccharides; Melatonin; Neural | 2015 |
Melatonin Modulates the Immune System Response and Inflammation in Diabetic Rats Experimentally-Induced by Alloxan.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Interleukin-1beta; Male; Melatonin; Rats; Ra | 2016 |
The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery.
Topics: Circadian Rhythm; Cognition Disorders; Coronary Artery Bypass; Female; Humans; Inflammation; Interce | 2015 |
Protective effect of melatonin-supported adipose-derived mesenchymal stem cells against small bowel ischemia-reperfusion injury in rat.
Topics: Adipose Tissue; Allografts; Animals; Gene Expression Regulation; Inflammation; Intestine, Small; Mal | 2015 |
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Topics: Animals; Apoptosis; Brain Injuries; Cytokines; Gene Expression Regulation; Inflammation; Male; Melat | 2015 |
Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance.
Topics: Animals; Cell Proliferation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Inflamm | 2015 |
A role for melatonin in maintaining the pro- and anti-inflammatory balance by influencing leukocyte migration and apoptosis in carp.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carps; Chemokines, CXC; Chemotaxis; Inflammation; Inte | 2015 |
Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob/ob) mice.
Topics: Adipokines; Adipose Tissue; Animals; Diet; Dietary Supplements; Fluorescent Antibody Technique; Infl | 2015 |
Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line.
Topics: Antioxidants; Cell Line, Tumor; Central Nervous System Stimulants; Culture Media, Serum-Free; Gene E | 2015 |
Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats.
Topics: Animals; Antioxidants; Apoptosis; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 9; Melat | 2015 |
Interleukin-17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection.
Topics: Animals; Antioxidants; Flow Cytometry; Inflammation; Interleukin-17; Lymphocyte Function-Associated | 2015 |
Melatonin attenuates hypertension-induced renal injury partially through inhibiting oxidative stress in rats.
Topics: Animals; Blood Pressure; Creatinine; Edema; Gene Expression Regulation; Heme Oxygenase-1; Hypertensi | 2016 |
Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise.
Topics: Animals; Biomarkers; Disease Models, Animal; Inflammation; Melatonin; Mice; Muscle, Skeletal; Perfor | 2015 |
Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chemotaxis; Disease Progression; Encephalomyelitis, Au | 2016 |
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Disease Models, Animal; Heme Oxygenase-1; Inflammatio | 2016 |
The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages.
Topics: Animals; Blotting, Western; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Immuno | 2016 |
Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis.
Topics: Adrenergic beta-Agonists; Animals; Catecholamines; Corticosterone; Inflammation; Isoproterenol; Lipo | 2017 |
Photoperiod- and Triiodothyronine-dependent Regulation of Reproductive Neuropeptides, Proinflammatory Cytokines, and Peripheral Physiology in Siberian Hamsters (Phodopus sungorus).
Topics: Animals; Body Weight; Circadian Rhythm; Cricetinae; Cytokines; Gonads; Hypothalamus; Inflammation; M | 2016 |
Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Interl | 2016 |
Melatonin can Ameliorate Radiation-Induced Oxidative Stress and Inflammation-Related Deterioration of Bone Quality in Rat Femur.
Topics: Animals; Bone and Bones; Bone Density; Diaphyses; Dose-Response Relationship, Radiation; Femur; Gamm | 2016 |
Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts.
Topics: Cancer-Associated Fibroblasts; Cell Survival; Coculture Techniques; Humans; Inflammation; Melatonin; | 2016 |
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.
Topics: Aging; Animals; Antioxidants; Cell Proliferation; Chronic Disease; Cytokines; Drugs, Chinese Herbal; | 2016 |
Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy.
Topics: Animals; Brain Injuries, Traumatic; Inflammation; Interleukin-1beta; Male; Melatonin; Mitophagy; Rat | 2016 |
Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway.
Topics: Animals; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Intra-Abdominal Hypertension; | 2016 |
Protective effect of melatonin on the development of abdominal aortic aneurysm in a rat model.
Topics: Animals; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Inflammation; Male; | 2017 |
Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway.
Topics: Animals; Animals, Newborn; Autophagy; Brain; Endoplasmic Reticulum Stress; Female; Inflammation; Lip | 2016 |
Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice.
Topics: Aging; Animals; Aorta; Biomarkers; Inflammation; Intra-Abdominal Fat; Male; Melatonin; Mice; Oxidati | 2017 |
Comparison of Melatonin, Hypertonic Saline, and Hydroxyethyl Starch for Resuscitation of Secondary Intra-Abdominal Hypertension in an Animal Model.
Topics: Abdomen; Animals; Disease Models, Animal; Female; Hydroxyethyl Starch Derivatives; Hypertension, Por | 2016 |
Molecular mechanisms of melatonin in the reversal of LPS-induced EMT in peritoneal mesothelial cells.
Topics: Antioxidants; Cell Line; Epithelial-Mesenchymal Transition; Epithelium; Gene Expression Regulation; | 2016 |
Melatonin modulates adiponectin expression on murine colitis with sleep deprivation.
Topics: Adiponectin; Animals; Antibodies; Body Weight; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay | 2016 |
PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Inflammation; Melatonin; Mice, | 2017 |
Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.
Topics: Animals; Cadmium; Carrier Proteins; Cell Death; Chemical and Drug Induced Liver Injury; Gene Express | 2017 |
Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.
Topics: Adult; Aged; Aged, 80 and over; Arylalkylamine N-Acetyltransferase; Female; Humans; Immunohistochemi | 2017 |
Melatonin prevents obesity through modulation of gut microbiota in mice.
Topics: Animals; Bacteroidetes; Blotting, Western; Central Nervous System Depressants; Diet, High-Fat; Fatty | 2017 |
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Topics: Animals; Anti-Inflammatory Agents; Chloranil; Disease Models, Animal; Extracellular Signal-Regulated | 2017 |
Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage.
Topics: Aging; Animals; Blotting, Western; Female; Heme Oxygenase-1; Inflammation; Interleukins; Lipid Perox | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Photoperiod-related changes in hormonal and immune status of male Siberian hamsters, Phodopus sungorus.
Topics: Acetylserotonin O-Methyltransferase; Animals; Cricetinae; Hydrocortisone; Immune System; Immunity, C | 2009 |
Melatonin protects against experimental reflux esophagitis.
Topics: Animals; Antioxidants; Cytokines; Drug Antagonism; Esophagitis, Peptic; Hemorrhage; Humans; Inflamma | 2009 |
[Determination of melatonin receptors in human blood mononuclear cells: clinical and experimental rationale].
Topics: Adult; Aged; Antibodies; Erythrocytes; Fluorescent Antibody Technique, Indirect; Gastrointestinal Di | 2009 |
Protective effects of melatonin against the damages of neuroendocrine-immune induced by lipopolysaccharide in diabetic rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antioxidants; Corticosterone; Corticotro | 2009 |
Protective effect of melatonin against the inflammatory response elicited by crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa).
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Chymases; Cnidarian Venoms; Edema; Histocytochemistry; | 2009 |
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri | 2009 |
Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis.
Topics: Alcohols; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytokines; Gene Expression Reg | 2009 |
Melatonin reduces cardiac inflammatory injury induced by acute exercise.
Topics: Animals; Cardiomyopathies; Cyclooxygenase 2; Disease Models, Animal; Inflammation; Intercellular Adh | 2009 |
Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation.
Topics: Animals; Antioxidants; Cell Line; Cell Survival; Gene Expression; Immunologic Factors; Inflammation; | 2010 |
Melatonin causes gene expression in aged animals to respond to inflammatory stimuli in a manner differing from that of young animals.
Topics: Aging; Animals; Brain; Gene Expression; Inflammation; Lipopolysaccharides; Male; Melatonin; Mice; Mi | 2008 |
Modeling the influence of circadian rhythms on the acute inflammatory response.
Topics: Algorithms; Animals; Circadian Rhythm; Computer Simulation; Cytokines; Endotoxemia; Humans; Hydrocor | 2010 |
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Topics: Analgesics; Animals; Colitis; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Melatonin; N | 2010 |
Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain.
Topics: Acetylcholinesterase; Animals; Biomarkers; Brain; Cytokines; Inflammation; Lipopolysaccharides; Male | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; | 2010 |
Antioxidant defence and inflammatory response in professional road cyclists during a 4-day competition.
Topics: Adaptation, Physiological; Adult; Antioxidants; Athletes; Bicycling; Creatine Kinase; Cytokines; Ery | 2010 |
The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Astrocytoma; Blotting, Western; C | 2010 |
Inflammation in the avian spleen: timing is everything.
Topics: Animals; Birds; Circadian Clocks; Cytokines; Inflammation; Interleukin-1beta; Lipopolysaccharides; M | 2010 |
Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis.
Topics: Antioxidants; Cells, Cultured; Endothelium, Vascular; Glutathione; Humans; Inflammation; Interleukin | 2011 |
High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.
Topics: Animals; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Cytokines; Free Radical Scav | 2012 |
Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity.
Topics: Animals; Chemical Warfare Agents; Disease Models, Animal; Inflammation; Isothiuronium; Kidney Diseas | 2012 |
Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase | 2012 |
Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Astrocytoma; Cytokines; | 2012 |
Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Male; Melatonin; Oxidative Stress; Rats; Rat | 2013 |
Endothelial and vascular smooth muscle cell dysfunction mediated by cyclophylin A and the atheroprotective effects of melatonin.
Topics: Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Cell Adhesion; Cell Movement; Cyclophilin | 2013 |
Melatonin improves bladder symptoms and may ameliorate bladder damage via increasing HO-1 in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Proliferation; Cystitis, Interstitial; Female; | 2013 |
[Effect of pretreatment with melatonin on the oxidative and inflammatory damage induced by hepatic ischemia/reperfusion in Zucker rats].
Topics: Age Factors; Animals; Inflammation; Liver; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Rats, Zu | 2011 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
A possible link between melatonin levels, stress and coronary heart disease.
Topics: Causality; Circadian Rhythm; Coronary Disease; Disease Progression; Humans; Inflammation; Interleuki | 2002 |
Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Pressure; Body Weight; Disease Models, Animal; Dr | 2003 |
Elevated serum melatonin is associated with the nocturnal worsening of asthma.
Topics: Adult; Asthma; Case-Control Studies; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Inf | 2003 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc | 2004 |
Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils.
Topics: Animals; Antioxidants; Bile Ducts; Cholestasis; Female; Glutathione; Inflammation; Kidney; Liver; Lu | 2004 |
Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes.
Topics: Acetic Acid; Animals; Colitis; Darkness; Ethanol; Female; Gastric Mucosa; Inflammation; Intestinal M | 2005 |
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Down-Regulation; Female; I-kappa B Proteins; Inflammatio | 2005 |
Anti-inflammatory effect of melatonin on A beta vaccination in mice.
Topics: Adenosine Triphosphatases; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Cell Membrane; | 2007 |
Melatonin-induced gene expression changes and its preventive effects on adriamycin-induced lipid peroxidation in rat liver.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Doxorubicin; Electron Transport; Fatty Acids; Ge | 2007 |
Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice.
Topics: Aging; Animals; Cytokines; Female; Inflammation; Male; Melatonin; Mice; Nitric Oxide | 2007 |
Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats.
Topics: Animals; Inflammation; Injections, Intravenous; Ischemic Attack, Transient; Leukocytes; Male; Melato | 2007 |
Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine.
Topics: Animals; Antioxidants; Circadian Rhythm; Inflammation; Intestine, Small; Male; Melatonin; Oxidative | 2007 |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
Topics: Actins; Animals; Blood Pressure; Cell Movement; Collagen Type IV; Creatinine; Disease Models, Animal | 2008 |
Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats.
Topics: Animals; Apoptosis; Axons; Calcium; Calpain; Caspase 3; Central Nervous System Depressants; Gene Exp | 2008 |
Melatonin accelerates the process of wound repair in full-thickness incisional wounds.
Topics: Animals; Antioxidants; Arginase; Cicatrix; Dermis; Inflammation; Male; Melatonin; Neovascularization | 2008 |
The regulation of prostaglandin biosynthesis: negative feedback mechanisms and the selective control of formation of I and 2 series prostaglandins: relevance to inflammation and immunity.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Blood Platelets; Colchicine; Feedback; Humans; Immun | 1980 |
Pineal-opioid system interactions in the control of immunoinflammatory responses.
Topics: Adult; Aged; Eosinophils; Female; Humans; Immunotherapy; Inflammation; Interleukin-2; Killer Cells, | 1994 |
Circadian rhythm in experimental granulomatous inflammation is modulated by melatonin.
Topics: Animals; Antioxidants; Capillary Permeability; Circadian Rhythm; Ganglionectomy; Granuloma; Inflamma | 1997 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 1997 |
Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Immunohistoc | 1999 |
Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice.
Topics: Adrenal Glands; Adrenalectomy; Animals; Capillary Permeability; Circadian Rhythm; Inflammation; Male | 2001 |
Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation.
Topics: Acute Disease; Animals; Carrageenan; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme A | 2001 |