melatonin has been researched along with Hypotension in 8 studies
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Hypotension is a frequent side-effect of cancer biotherapies with cytokines." | 6.68 | Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin. ( Ardizzoia, A; Barni, S; Braczkowski, R; Brivio, F; Lissoni, P; Maestroni, GJ; Pelizzoni, F; Pittalis, S; Tancini, G; Zubelewicz, B, 1996) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility." | 3.72 | Impact of treatment with melatonin on cerebral circulation in old rats. ( Atkinson, J; Chillon, JM; Delagrange, P; Dupuis, F; Limiñana, P; Régrigny, O; Scalbert, E, 2004) |
| "Hypotension is a frequent side-effect of cancer biotherapies with cytokines." | 2.68 | Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin. ( Ardizzoia, A; Barni, S; Braczkowski, R; Brivio, F; Lissoni, P; Maestroni, GJ; Pelizzoni, F; Pittalis, S; Tancini, G; Zubelewicz, B, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cvikova, D | 1 |
| Sutovska, H | 1 |
| Babarikova, K | 1 |
| Molcan, L | 1 |
| Johnson, HE | 1 |
| Dotson, JM | 1 |
| Ellis, CS | 1 |
| Hill, KK | 1 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chao, CM | 1 |
| Chang, CK | 1 |
| Lin, MT | 1 |
| Chang, CP | 1 |
| Dupuis, F | 2 |
| Régrigny, O | 3 |
| Atkinson, J | 3 |
| Limiñana, P | 2 |
| Delagrange, P | 3 |
| Scalbert, E | 3 |
| Chillon, JM | 2 |
| Lissoni, P | 1 |
| Pittalis, S | 1 |
| Ardizzoia, A | 1 |
| Brivio, F | 1 |
| Barni, S | 1 |
| Tancini, G | 1 |
| Pelizzoni, F | 1 |
| Maestroni, GJ | 1 |
| Zubelewicz, B | 1 |
| Braczkowski, R | 1 |
| Lartaud-Idjouadiene, I | 1 |
| van de Luit, L | 1 |
| van der Meulen, J | 1 |
| Cleophas, TJ | 1 |
| Zwinderman, AH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for melatonin and Hypotension
| Article | Year |
|---|---|
Hypotensive effects of melatonin in rats: Focus on the model, measurement, application, and main mechanisms.
Topics: Animals; Blood Pressure; Cardiovascular System; Humans; Hypertension; Hypotension; Melatonin; Mice; | 2022 |
1 trial available for melatonin and Hypotension
| Article | Year |
|---|---|
Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin.
Topics: Administration, Oral; Adult; Aged; Cytokines; Drug Therapy, Combination; Female; Humans; Hypotension | 1996 |
6 other studies available for melatonin and Hypotension
| Article | Year |
|---|---|
Severe Hypotension in an Adolescent After a Melatonin Overdose.
Topics: Adolescent; Drug Overdose; Female; Fluid Therapy; Humans; Hypotension; Melatonin; Sleep Initiation a | 2019 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Impact of treatment with melatonin on cerebral circulation in old rats.
Topics: Aging; Animals; Arterioles; Brain; Cerebrovascular Circulation; Hypotension; Male; Melatonin; Rats; | 2004 |
Melatonin improves cerebral circulation security margin in rats.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Frontal Lobe; Heart Rate; Hemo | 1998 |
Amplified amplitudes of circadian rhythms and nighttime hypotension in patients with chronic fatigue syndrome: improvement by inopamil but not by melatonin.
Topics: Adult; Blood Pressure; Circadian Rhythm; Deoxyepinephrine; Fatigue Syndrome, Chronic; Female; Heart | 1998 |
Cerebral arteriolar structure and function in pinealectomized rats.
Topics: Animals; Arterioles; Cerebrovascular Circulation; Homeostasis; Hypotension; Male; Melatonin; Pineal | 2001 |