melatonin has been researched along with Hypotension, Orthostatic in 3 studies
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin concentration was 14 +/- 11 pg ml(-1) before ingestion and was significantly increased at each time point (peaking at 75 min; 1830 +/- 848 pg ml(-1))." | 2.71 | Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans. ( Ray, CA, 2003) |
| "Two patients with sympathotonic orthostatic hypotension excreted greater amounts of 6-hydroxymelatonin than any of the control subjects." | 1.26 | Urinary 6-hydroxymelatonin excretion in patients with orthostatic hypotension. ( Kopin, IJ; Markey, SP; Polinsky, RJ; Tetsuo, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lewis, NC | 1 |
| Jones, H | 1 |
| Ainslie, PN | 1 |
| Thompson, A | 1 |
| Marrin, K | 1 |
| Atkinson, G | 1 |
| Ray, CA | 1 |
| Tetsuo, M | 1 |
| Polinsky, RJ | 1 |
| Markey, SP | 1 |
| Kopin, IJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for melatonin and Hypotension, Orthostatic
| Article | Year |
|---|---|
Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans.
Topics: Adult; Anticonvulsants; Blood Pressure; Cold Temperature; Female; Hand Strength; Heart Rate; Humans; | 2003 |
2 other studies available for melatonin and Hypotension, Orthostatic
| Article | Year |
|---|---|
Influence of nocturnal and daytime sleep on initial orthostatic hypotension.
Topics: Adult; Blood Pressure; Body Temperature; Cerebrovascular Circulation; Heart Rate; Humans; Hypotensio | 2015 |
Urinary 6-hydroxymelatonin excretion in patients with orthostatic hypotension.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Hypotension, Orthostatic; Male; Melatonin; Nerv | 1981 |