Page last updated: 2024-10-19

melatonin and Hip Fractures

melatonin has been researched along with Hip Fractures in 11 studies

Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).

Research Excerpts

ExcerptRelevanceReference
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium."9.19Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014)
"To assess if high morning plasma melatonin concentrations were associated with delirium."7.85Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."7.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."6.76The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011)
"Patients enrolled in a randomized controlled clinical trial of melatonin versus placebo on occurrence of delirium in hip-fracture patients."5.20In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration. ( Blom, MT; de Boer, A; de Jonghe, A; de Rooij, SE; Jansen, S; Tan, HL; van der Velde, N; van Munster, BC, 2015)
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium."5.19Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014)
"To assess if high morning plasma melatonin concentrations were associated with delirium."3.85Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."3.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"Delirium is a common neuropsychiatric syndrome with considerable heterogeneity in clinical profile."2.82Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium. ( Adamis, D; de Jonghe, A; de Rooij, SE; Meagher, DJ; Scholtens, RM; van Munster, BC, 2016)
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."2.76The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (63.64)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Sigaut, S1
Couffignal, C1
Esposito-Farèse, M1
Degos, V1
Molliex, S1
Boddaert, J1
Raynaud-Simon, A1
Durand-Zaleski, I1
Marcault, E1
Jacota, M1
Dahmani, S1
Paugam-Burtz, C1
Weiss, E1
Yang, T1
Wu, J1
Ding, X1
Zhou, B1
Xiong, Y1
Yuan, Y2
Song, Y2
Wang, G2
Jia, Y2
Zhou, Y2
Mi, X2
Jia, X2
Wang, X2
Liu, C2
Li, Y2
Shi, C2
Han, Y2
Guo, X2
Zhang, W2
Li, Z2
Liu, Y1
Liu, L1
Li, W1
Li, X1
Cai, N1
Wang, JQ1
Vuylsteke, A1
Scholtens, RM3
van Munster, BC7
van Faassen, M1
van Kempen, MF1
Kema, IP1
de Rooij, SE7
van de Glind, EM1
Vural, EM1
Scholten, E1
Hooft, L1
Portegijs, E1
de Jonghe, A4
Goslings, JC2
Kloen, P2
van Rees, C2
Wolvius, R2
van Velde, R2
Levi, M1
de Haan, RJ1
Blom, MT1
Jansen, S1
de Boer, A1
Tan, HL1
van der Velde, N1
Adamis, D1
Meagher, DJ1
Vellekoop, AE1
Vrouenraets, BC1
van Oosten, HE1
Levi, MM1
Korevaar, JC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients: a Randomized Controlled Trial[NCT04335968]Phase 3790 participants (Anticipated)Interventional2021-01-23Recruiting
Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314]Phase 3277 participants (Actual)Interventional2016-07-31Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.)
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]Phase 260 participants (Actual)Interventional2014-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Days Utilizing Restraints

Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventiondays (Median)
Melatonin0
Cellulose Microcrystylline0

Delirium

Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

InterventionParticipants (Count of Participants)
Melatonin2
Cellulose Microcrystylline8

Length of Hospital Stay

Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days

Interventiondays (Mean)
Melatonin4.58
Cellulose Microcrystylline4.71

Number of Delirium Anti-psychotic Drug Doses Utilized for Delirium During the First 14 Days of Hospitalization.

Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventionnumber of doses per days of hospitalizat (Median)
Melatonin0
Cellulose Microcrystylline0

Trials

6 trials available for melatonin and Hip Fractures

ArticleYear
Melatonin for prevention of postoperative delirium after lower limb fracture surgery in elderly patients (DELIRLESS): study protocol for a multicentre randomised controlled trial.
    BMJ open, 2021, 12-24, Volume: 11, Issue:12

    Topics: Aged; Delirium; Double-Blind Method; Hip Fractures; Humans; Lower Extremity; Melatonin; Multicenter

2021
Barriers to and facilitators of participation of older adults in a placebo-controlled randomized clinical trial.
    Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8

    Topics: Aged; Aged, 80 and over; Attitude to Health; Caregivers; Chronobiology Disorders; Comprehension; Del

2013
Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Oct-07, Volume: 186, Issue:14

    Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Delirium; Double-Blind Method; Female; Frac

2014
In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration.
    The journal of nutrition, health & aging, 2015, Volume: 19, Issue:5

    Topics: Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Delirium; Electrocardiography; Female; Halo

2015
Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium.
    International psychogeriatrics, 2016, Volume: 28, Issue:7

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Cognition; Delirium; Double-Blind Metho

2016
The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial.
    BMC geriatrics, 2011, Jul-05, Volume: 11

    Topics: Aged; Delirium; Double-Blind Method; Female; Follow-Up Studies; Hip Fractures; Humans; Male; Melaton

2011

Other Studies

5 other studies available for melatonin and Hip Fractures

ArticleYear
The association of melatonin use and hip fracture: a matched cohort study.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023, Volume: 34, Issue:6

    Topics: Adult; Benzodiazepines; Cohort Studies; Hip Fractures; Humans; Hypnotics and Sedatives; Melatonin

2023
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial.
    BMJ open, 2021, 02-12, Volume: 11, Issue:2

    Topics: Aged; Anesthesia, Conduction; Circadian Rhythm; Delirium; Hip Fractures; Humans; Melatonin; Postoper

2021
Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial.
    EBioMedicine, 2021, Volume: 70

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Spinal; Circadian Rhythm; Emergence Deliri

2021
Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
    Mechanisms of ageing and development, 2017, Volume: 167

    Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Circadian Rhythm; Cognition Disorders; Delirium; Fe

2017
Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Aged; Aged, 80 and over; Circadian Rhythm; Delirium; Female; Hip Fractures; Humans; Male; Melatonin;

2016