melatonin has been researched along with Hip Fractures in 11 studies
Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
Excerpt | Relevance | Reference |
---|---|---|
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium." | 9.19 | Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014) |
"To assess if high morning plasma melatonin concentrations were associated with delirium." | 7.85 | Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017) |
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium." | 7.83 | Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016) |
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium." | 6.76 | The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011) |
"Patients enrolled in a randomized controlled clinical trial of melatonin versus placebo on occurrence of delirium in hip-fracture patients." | 5.20 | In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration. ( Blom, MT; de Boer, A; de Jonghe, A; de Rooij, SE; Jansen, S; Tan, HL; van der Velde, N; van Munster, BC, 2015) |
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium." | 5.19 | Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014) |
"To assess if high morning plasma melatonin concentrations were associated with delirium." | 3.85 | Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017) |
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium." | 3.83 | Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016) |
"Delirium is a common neuropsychiatric syndrome with considerable heterogeneity in clinical profile." | 2.82 | Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium. ( Adamis, D; de Jonghe, A; de Rooij, SE; Meagher, DJ; Scholtens, RM; van Munster, BC, 2016) |
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium." | 2.76 | The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 7 (63.64) | 24.3611 |
2020's | 4 (36.36) | 2.80 |
Authors | Studies |
---|---|
Sigaut, S | 1 |
Couffignal, C | 1 |
Esposito-Farèse, M | 1 |
Degos, V | 1 |
Molliex, S | 1 |
Boddaert, J | 1 |
Raynaud-Simon, A | 1 |
Durand-Zaleski, I | 1 |
Marcault, E | 1 |
Jacota, M | 1 |
Dahmani, S | 1 |
Paugam-Burtz, C | 1 |
Weiss, E | 1 |
Yang, T | 1 |
Wu, J | 1 |
Ding, X | 1 |
Zhou, B | 1 |
Xiong, Y | 1 |
Yuan, Y | 2 |
Song, Y | 2 |
Wang, G | 2 |
Jia, Y | 2 |
Zhou, Y | 2 |
Mi, X | 2 |
Jia, X | 2 |
Wang, X | 2 |
Liu, C | 2 |
Li, Y | 2 |
Shi, C | 2 |
Han, Y | 2 |
Guo, X | 2 |
Zhang, W | 2 |
Li, Z | 2 |
Liu, Y | 1 |
Liu, L | 1 |
Li, W | 1 |
Li, X | 1 |
Cai, N | 1 |
Wang, JQ | 1 |
Vuylsteke, A | 1 |
Scholtens, RM | 3 |
van Munster, BC | 7 |
van Faassen, M | 1 |
van Kempen, MF | 1 |
Kema, IP | 1 |
de Rooij, SE | 7 |
van de Glind, EM | 1 |
Vural, EM | 1 |
Scholten, E | 1 |
Hooft, L | 1 |
Portegijs, E | 1 |
de Jonghe, A | 4 |
Goslings, JC | 2 |
Kloen, P | 2 |
van Rees, C | 2 |
Wolvius, R | 2 |
van Velde, R | 2 |
Levi, M | 1 |
de Haan, RJ | 1 |
Blom, MT | 1 |
Jansen, S | 1 |
de Boer, A | 1 |
Tan, HL | 1 |
van der Velde, N | 1 |
Adamis, D | 1 |
Meagher, DJ | 1 |
Vellekoop, AE | 1 |
Vrouenraets, BC | 1 |
van Oosten, HE | 1 |
Levi, MM | 1 |
Korevaar, JC | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients: a Randomized Controlled Trial[NCT04335968] | Phase 3 | 790 participants (Anticipated) | Interventional | 2021-01-23 | Recruiting | ||
Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314] | Phase 3 | 277 participants (Actual) | Interventional | 2016-07-31 | Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.) | ||
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172] | Phase 2 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
Intervention | days (Median) |
---|---|
Melatonin | 0 |
Cellulose Microcrystylline | 0 |
Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
Intervention | Participants (Count of Participants) |
---|---|
Melatonin | 2 |
Cellulose Microcrystylline | 8 |
Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days
Intervention | days (Mean) |
---|---|
Melatonin | 4.58 |
Cellulose Microcrystylline | 4.71 |
Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
Intervention | number of doses per days of hospitalizat (Median) |
---|---|
Melatonin | 0 |
Cellulose Microcrystylline | 0 |
6 trials available for melatonin and Hip Fractures
Article | Year |
---|---|
Melatonin for prevention of postoperative delirium after lower limb fracture surgery in elderly patients (DELIRLESS): study protocol for a multicentre randomised controlled trial.
Topics: Aged; Delirium; Double-Blind Method; Hip Fractures; Humans; Lower Extremity; Melatonin; Multicenter | 2021 |
Barriers to and facilitators of participation of older adults in a placebo-controlled randomized clinical trial.
Topics: Aged; Aged, 80 and over; Attitude to Health; Caregivers; Chronobiology Disorders; Comprehension; Del | 2013 |
Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Delirium; Double-Blind Method; Female; Frac | 2014 |
In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration.
Topics: Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Delirium; Electrocardiography; Female; Halo | 2015 |
Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium.
Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Cognition; Delirium; Double-Blind Metho | 2016 |
The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial.
Topics: Aged; Delirium; Double-Blind Method; Female; Follow-Up Studies; Hip Fractures; Humans; Male; Melaton | 2011 |
5 other studies available for melatonin and Hip Fractures
Article | Year |
---|---|
The association of melatonin use and hip fracture: a matched cohort study.
Topics: Adult; Benzodiazepines; Cohort Studies; Hip Fractures; Humans; Hypnotics and Sedatives; Melatonin | 2023 |
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial.
Topics: Aged; Anesthesia, Conduction; Circadian Rhythm; Delirium; Hip Fractures; Humans; Melatonin; Postoper | 2021 |
Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Spinal; Circadian Rhythm; Emergence Deliri | 2021 |
Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Circadian Rhythm; Cognition Disorders; Delirium; Fe | 2017 |
Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Delirium; Female; Hip Fractures; Humans; Male; Melatonin; | 2016 |