melatonin has been researched along with Hepatolenticular Degeneration in 2 studies
Hepatolenticular Degeneration: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is an endogenously-produced molecule that functions as a copper chelator, a potent antioxidant, and as a suppressor of endoplasmic reticulum stress and the unfolded protein response in both the liver and the brain, while also reducing fibrosis/cirrhosis in the liver." | 1.51 | Melatonin: A hypothesis regarding its use to treat Wilson disease. ( Ma, Q; Reiter, RJ; Sharma, R, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, R | 1 |
| Reiter, RJ | 1 |
| Ma, Q | 1 |
| Huang, Z | 1 |
| Deng, J | 1 |
| Borjigin, J | 1 |
2 other studies available for melatonin and Hepatolenticular Degeneration
| Article | Year |
|---|---|
Melatonin: A hypothesis regarding its use to treat Wilson disease.
Topics: Animals; Antioxidants; Bile; Brain; Butyrates; Chelating Agents; Chelation Therapy; Copper; Copper-T | 2019 |
A novel H28Y mutation in LEC rats leads to decreased NAT protein stability in vivo and in vitro.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Animals; Arylalkylamine N-Acetyltransferase; Cat | 2005 |