melatonin has been researched along with Hemorrhagic Shock in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models." | 7.88 | Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. ( Beilman, GJ; Mulier, KE; Suryanarayanan, R; Thakral, S; Wolf, A, 2018) |
| "Melatonin improves hepatic perfusion after hemorrhagic shock and may reduce stress-induced gastric lesions." | 7.85 | Melatonin pretreatment improves gastric mucosal blood flow and maintains intestinal barrier function during hemorrhagic shock in dogs. ( Bauer, I; Hoffmann, T; Mathes, AM; Mettler-Altmann, T; Picker, O; Truse, R; Vollmer, C; Wallenfang, M; Weber, APM, 2017) |
| "Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models." | 7.85 | D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study. ( Beilman, GJ; Mulier, KE; Muratore, SL; Wolf, A, 2017) |
| "D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock." | 7.81 | Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015) |
| " Compared with vehicle controls, melatonin therapy after hemorrhagic shock significantly improved plasma disappearance rate of indocyanine green, hepatic redox state, hepatocellular injury, and hepatic perfusion index." | 7.74 | Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Rensing, H; Waibel, L; Weiler, J; Wolf, B, 2008) |
| "Melatonin (MT) is an indoleamine hormone that can counteract ischemia‑induced organ injury through its antioxidant effects." | 5.62 | Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway. ( Cai, QQ; Li, HW; Wu, XL; Yang, ZH; Ying, P, 2021) |
| "Previous studies in rat models of hemorrhagic shock have suggested a benefit." | 5.38 | Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock. ( Beilman, GJ; Greenberg, JJ; Lexcen, DR; Luzcek, E; Mulier, KE, 2012) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 5.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "In a model of hemorrhagic shock (MAP 35 +/- 5 mmHg for 90 min) and reperfusion (2 h), we measured nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) autofluorescence, hepatic microcirculation, and hepatocellular injury by intravital microscopy, as well as plasma disappearance rate of indocyanine green (PDRICG) as a sensitive maker of liver function in rat." | 5.35 | Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Pradarutti, S; Rensing, H; Weiler, J; Wolf, B; Ziegeler, S, 2008) |
| "Although hemorrhagic shock leads to significant alterations of several hormones, e." | 5.29 | Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN mice. ( Ayala, A; Chaudry, IH; DeMaso, CM; Wichmann, MW; Zellweger, R, 1996) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 5.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| "d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models." | 3.88 | Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. ( Beilman, GJ; Mulier, KE; Suryanarayanan, R; Thakral, S; Wolf, A, 2018) |
| "Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models." | 3.85 | D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study. ( Beilman, GJ; Mulier, KE; Muratore, SL; Wolf, A, 2017) |
| "D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock." | 3.81 | Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015) |
| "A small-volume therapeutic approach based on the biochemistry of hibernating mammals was evaluated to test the hypothesis that passive hypothermia and systemic administration of d-β-hydroxybutyrate (d-BHB) plus melatonin will increase survival of animals subjected to hemorrhagic shock ([HS] 60% blood loss)." | 3.76 | Small-volume d-β-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats. ( Andrews, MT; Drewes, LR; Klein, AH; Wendroth, SM, 2010) |
| " Compared with vehicle controls, melatonin therapy after hemorrhagic shock significantly improved plasma disappearance rate of indocyanine green, hepatic redox state, hepatocellular injury, and hepatic perfusion index." | 3.74 | Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Rensing, H; Waibel, L; Weiler, J; Wolf, B, 2008) |
| "While we focus on hemorrhagic shock, many of the described treatments may be used in other situations of hypoxia or ischemia/reperfusion injury." | 2.58 | Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock. ( Beilman, GJ; Lusczek, ER; Wolf, A, 2018) |
| "Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity." | 2.46 | Hepatoprotective actions of melatonin: possible mediation by melatonin receptors. ( Mathes, AM, 2010) |
| "Melatonin (MT) is an indoleamine hormone that can counteract ischemia‑induced organ injury through its antioxidant effects." | 1.62 | Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway. ( Cai, QQ; Li, HW; Wu, XL; Yang, ZH; Ying, P, 2021) |
| "Melatonin has been demonstrated to reduce liver damage in different models of stress." | 1.42 | Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis. ( Abend, M; Fink, T; Glas, M; Kleber, A; Mathes, AM; Ruf, CG; Volk, T; Wolf, A; Wolf, B, 2015) |
| "Previous studies in rat models of hemorrhagic shock have suggested a benefit." | 1.38 | Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock. ( Beilman, GJ; Greenberg, JJ; Lexcen, DR; Luzcek, E; Mulier, KE, 2012) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 1.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "In a model of hemorrhagic shock (MAP 35 +/- 5 mmHg for 90 min) and reperfusion (2 h), we measured nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) autofluorescence, hepatic microcirculation, and hepatocellular injury by intravital microscopy, as well as plasma disappearance rate of indocyanine green (PDRICG) as a sensitive maker of liver function in rat." | 1.35 | Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Pradarutti, S; Rensing, H; Weiler, J; Wolf, B; Ziegeler, S, 2008) |
| "To study this, soft-tissue trauma (2." | 1.29 | Melatonin administration attenuates depressed immune functions trauma-hemorrhage. ( Ayala, A; Chaudry, IH; Wichmann, MW; Zellweger, R, 1996) |
| "Melatonin-treated mice (50 mg/kg) had lower serum IL-6 levels (368 +/- 154 vs 1078 +/- 146 pg/ml) and lazaroid-treated mice had lower gamma-IFN levels (7 +/- 6 vs 52 +/- 15 pg/ml) compared to those of the untreated group (P < 0." | 1.29 | Melatonin and a 21-aminosteroid attenuate shock after hemorrhage but differentially affect serum cytokines. ( Affleck, DG; Barton, RG; Hinson, DM; Shao, Y; Shelby, J; Sullivan, DJ, 1996) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 1.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 15 (65.22) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Li, HW | 1 |
| Ying, P | 1 |
| Cai, QQ | 1 |
| Yang, ZH | 1 |
| Wu, XL | 1 |
| Vollmer, C | 1 |
| Weber, APM | 1 |
| Wallenfang, M | 1 |
| Hoffmann, T | 1 |
| Mettler-Altmann, T | 1 |
| Truse, R | 1 |
| Bauer, I | 3 |
| Picker, O | 1 |
| Mathes, AM | 5 |
| Perez de Lara Rodriguez, CE | 1 |
| Drewes, LR | 2 |
| Andrews, MT | 2 |
| Wolf, A | 6 |
| Mulier, KE | 4 |
| Muratore, SL | 1 |
| Beilman, GJ | 6 |
| Thakral, S | 2 |
| Suryanarayanan, R | 2 |
| Lusczek, ER | 1 |
| Iyegha, UP | 1 |
| Asghar, JI | 1 |
| Kleber, A | 1 |
| Ruf, CG | 1 |
| Fink, T | 1 |
| Glas, M | 1 |
| Wolf, B | 3 |
| Volk, T | 1 |
| Abend, M | 1 |
| Chang, M | 1 |
| Tang, H | 1 |
| Liu, D | 1 |
| Li, Y | 1 |
| Zhang, L | 1 |
| Hsu, JT | 2 |
| Le, PH | 1 |
| Lin, CJ | 2 |
| Chen, TH | 2 |
| Kuo, CJ | 2 |
| Chiang, KC | 1 |
| Yeh, TS | 2 |
| Yang, FL | 1 |
| Subeq, YM | 1 |
| Lee, CJ | 1 |
| Lee, RP | 1 |
| Peng, TC | 1 |
| Hsu, BG | 1 |
| Klein, AH | 1 |
| Wendroth, SM | 1 |
| Lexcen, DR | 1 |
| Luzcek, E | 1 |
| Greenberg, JJ | 1 |
| Wang, F | 1 |
| Hwang, TL | 1 |
| Jan, YY | 1 |
| Kubulus, D | 2 |
| Pradarutti, S | 1 |
| Bentley, A | 2 |
| Weiler, J | 2 |
| Ziegeler, S | 1 |
| Rensing, H | 2 |
| Waibel, L | 1 |
| Miskovitz, P | 1 |
| Wichmann, MW | 3 |
| Zellweger, R | 2 |
| Ayala, A | 3 |
| Chaudry, IH | 3 |
| DeMaso, CM | 1 |
| Sullivan, DJ | 1 |
| Shelby, J | 1 |
| Shao, Y | 1 |
| Affleck, DG | 1 |
| Hinson, DM | 1 |
| Barton, RG | 1 |
| Haisken, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prognostic Value of Indocyanine Clearance Rate for Sepsis Patients in ICU[NCT01447836] | 100 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Hemorrhagic Shock
| Article | Year |
|---|---|
Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock.
Topics: Animals; Hibernation; Humans; Hydrogen Sulfide; Melatonin; Reperfusion Injury; Shock, Hemorrhagic | 2018 |
Hepatoprotective actions of melatonin: possible mediation by melatonin receptors.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Humans; Liver; Melatonin; Oxidative Stress | 2010 |
21 other studies available for melatonin and Hemorrhagic Shock
| Article | Year |
|---|---|
Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway.
Topics: Animals; Disease Models, Animal; Humans; Liver; Male; Melatonin; NF-kappa B; NF-KappaB Inhibitor alp | 2021 |
Melatonin pretreatment improves gastric mucosal blood flow and maintains intestinal barrier function during hemorrhagic shock in dogs.
Topics: Animals; Cross-Over Studies; Dogs; Female; Gastric Mucosa; Intestines; Melatonin; Microcirculation; | 2017 |
Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Dimethyl Sulfoxide; Fluid Therapy; Hibernation; Male; Melatonin; Rat | 2017 |
D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Development and in vivo evaluation of a novel lyophilized formulation for the treatment of hemorrhagic shock.
Topics: 3-Hydroxybutyric Acid; Animals; Chemistry, Pharmaceutical; Dimethyl Sulfoxide; Disease Models, Anima | 2018 |
Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; 3-Hydroxybutyric Acid; Animals; Dimethyl Sulfoxide; Disease Model | 2018 |
Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma.
Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Arterial Pressure; Aspartate Aminotransferases | 2015 |
Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Disease Models, Animal; Gene Expression Profiling; Gene Ex | 2015 |
Comparison of Melatonin, Hypertonic Saline, and Hydroxyethyl Starch for Resuscitation of Secondary Intra-Abdominal Hypertension in an Animal Model.
Topics: Abdomen; Animals; Disease Models, Animal; Female; Hydroxyethyl Starch Derivatives; Hypertension, Por | 2016 |
Mechanism of salutary effects of melatonin-mediated liver protection after trauma-hemorrhage: p38 MAPK-dependent iNOS/HIF-1α pathway.
Topics: Animals; Antioxidants; Cytokines; Enzyme Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Imid | 2017 |
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Heart Rate; Interleukin-6; Intestine, | 2011 |
Small-volume d-β-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Fluid Therapy; Male; Melatonin; Rats; Rats, Sprague-Dawley; Shock, H | 2010 |
Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Mal | 2012 |
Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway.
Topics: Adenosine Triphosphate; Alanine Transaminase; Androstadienes; Animals; Aspartate Aminotransferases; | 2012 |
Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Indocyanine Green; Liver; Liver Circulation; Male; Melatonin; NADP; | 2008 |
Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats.
Topics: Animals; Antioxidants; Coloring Agents; Disease Models, Animal; Indocyanine Green; Liver; Liver Func | 2008 |
Melatonin, shedding new light on darkness.
Topics: Animals; Antioxidants; Coloring Agents; Disease Models, Animal; Humans; Indocyanine Green; Liver; Me | 2008 |
Melatonin administration attenuates depressed immune functions trauma-hemorrhage.
Topics: Acquired Immunodeficiency Syndrome; Analysis of Variance; Animals; Corticosterone; Humans; Interleuk | 1996 |
Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN mice.
Topics: Animals; Female; Kinetics; Male; Melatonin; Mice; Mice, Inbred C3H; Pineal Gland; Proestrus; Sex Cha | 1996 |
Melatonin and a 21-aminosteroid attenuate shock after hemorrhage but differentially affect serum cytokines.
Topics: Animals; Blood Pressure; Cells, Cultured; Crystalloid Solutions; Fluid Therapy; Interferon-gamma; In | 1996 |
Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.
Topics: Animals; Body Weight; Cecum; Hemorrhage; Ligation; Male; Melatonin; Mice; Mice, Inbred C3H; Sepsis; | 1996 |