melatonin has been researched along with Heatstroke in 4 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin may protect against HS-induced myocardial injury in male rats by mitigating oxidative stress and inflammation." | 7.88 | Melatonin provides protection against heat stroke-induced myocardial injury in male rats. ( Chang, CP; Chao, CM; Lin, CH; Lin, MT; Lin, S; Lin, X; Liu, L; Wen, S; Ye, Z; Zhao, T; Zuo, D, 2018) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 7.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 7.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
| "Melatonin may protect against HS-induced myocardial injury in male rats by mitigating oxidative stress and inflammation." | 3.88 | Melatonin provides protection against heat stroke-induced myocardial injury in male rats. ( Chang, CP; Chao, CM; Lin, CH; Lin, MT; Lin, S; Lin, X; Liu, L; Wen, S; Ye, Z; Zhao, T; Zuo, D, 2018) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 3.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 3.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, X | 1 |
| Zhao, T | 1 |
| Lin, CH | 2 |
| Zuo, D | 2 |
| Ye, Z | 1 |
| Lin, S | 1 |
| Wen, S | 1 |
| Liu, L | 1 |
| Lin, MT | 4 |
| Chang, CP | 2 |
| Chao, CM | 2 |
| Tian, YF | 1 |
| Hsu, SF | 1 |
| Lin, XJ | 1 |
| Mei, GP | 1 |
| Liu, J | 1 |
| Li, YL | 1 |
| Liu, SJ | 1 |
| Zhao, TB | 1 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chang, CK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for melatonin and Heatstroke
| Article | Year |
|---|---|
Melatonin provides protection against heat stroke-induced myocardial injury in male rats.
Topics: Animals; Cardiotonic Agents; Heat Stroke; Inflammation; Male; Melatonin; Myocardial Infarction; Oxid | 2018 |
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi | 2013 |
Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Heat Stroke; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1 | 2011 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |