melatonin has been researched along with Headache in 28 studies
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The occurrence of headache and its change after treatment with melatonin 5 mg were studied in 30 patients with delayed sleep phase syndrome." | 9.08 | Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; van der Meer, YG, 1998) |
| " Incidence of delirium was not significantly lower in patients who received melatonin, with an odd ratio, OR (95%Cl) of 0." | 9.05 | The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. ( Khor, AJ; Ng, KT; Teoh, WY, 2020) |
| "Headache is a well-documented side effect of indomethacin in the older medical literature; however, it has rarely been commented on in indomethacin-responsive hemicrania continua." | 7.80 | Melatonin responsive hemicrania continua in which indomethacin was associated with contralateral headache. ( Hollingworth, M; Young, TM, 2014) |
| "The cyclic nature of some of headache disorders is closely related to melatonin, which is secreted by the pineal gland." | 7.78 | Nocturnal headache associated with melatonin deficiency due to a pineal gland cyst. ( Ipekdal, IH; Karadaş, O; Odabaşi, Z; Ulaş, UH, 2012) |
| "This was a randomized, double-blind trial of melatonin (3 mg or 6 mg) versus placebo for migraine prevention in 10-17 year-olds with 4-28/28 headache days at baseline." | 5.69 | Melatonin for migraine prevention in children and adolescents: A randomized, double-blind, placebo-controlled trial after single-blind placebo lead-in. ( Allen, IE; Gelfand, AA; Greene, K; Grimes, B; Irwin, S; Powers, SW; Qubty, W; Szperka, CL; Waung, M, 2023) |
| "A pineal cyst is a benign affection of the human pineal gland on the borderline between pathology and normality." | 5.46 | Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection. ( Beneš, V; Bradáč, O; Májovský, M; Netuka, D; Pospíšilová, L; Řezáčová, L; Sumová, A, 2017) |
| "The occurrence of headache and its change after treatment with melatonin 5 mg were studied in 30 patients with delayed sleep phase syndrome." | 5.08 | Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; van der Meer, YG, 1998) |
| " Incidence of delirium was not significantly lower in patients who received melatonin, with an odd ratio, OR (95%Cl) of 0." | 5.05 | The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. ( Khor, AJ; Ng, KT; Teoh, WY, 2020) |
| "Melatonin, the main pineal secreting hormone, has been extensively studied in primary and secondary headache disorders." | 5.01 | Current understanding of pineal gland structure and function in headache. ( Amaral, FG; Cipolla-Neto, J; Peres, MF; Valença, MM, 2019) |
| " This article focuses on the following specific neurologic diseases: nocturnal frontal lobe epilepsy and abnormal motor behaviors of epileptic origin, evaluating differential diagnosis with parasomnias; achondroplasia, confirming the crucial role of craniofacial deformity in determining sleep-disordered breathing; neuromuscular diseases, mainly Duchenne's muscular dystrophy and myotonic dystrophy; cerebral palsy, evaluating either the features of sleep architecture and the importance of the respiratory problems associated; headaches, confirming the strict relationships with sleep in terms of neurochemical and neurobehavioral substrates; and finally a review on the effectiveness of melatonin for sleep problems in children with neurologic syndromes and mental retardation, blindness, and epilepsy." | 4.81 | Sleep disorders in children with neurologic diseases. ( Bruni, O; Zucconi, M, 2001) |
| "Headache is a well-documented side effect of indomethacin in the older medical literature; however, it has rarely been commented on in indomethacin-responsive hemicrania continua." | 3.80 | Melatonin responsive hemicrania continua in which indomethacin was associated with contralateral headache. ( Hollingworth, M; Young, TM, 2014) |
| "The cyclic nature of some of headache disorders is closely related to melatonin, which is secreted by the pineal gland." | 3.78 | Nocturnal headache associated with melatonin deficiency due to a pineal gland cyst. ( Ipekdal, IH; Karadaş, O; Odabaşi, Z; Ulaş, UH, 2012) |
| "Migraine is a chronic disease of global concern, regardless of socio-economic and cultural background." | 2.82 | The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research. ( Cegielska, J; Domitrz, I; Zduńska, A, 2022) |
| "The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes all marked by unilateral headache and ipsilateral cranial autonomic features." | 2.61 | Trigeminal Autonomic Cephalalgias. ( Burish, MJ; Rozen, TD, 2019) |
| " The aim of this review was to present and evaluate the literature concerning the possible adverse effects and safety of exogenous melatonin in humans." | 2.53 | The Safety of Melatonin in Humans. ( Andersen, LP; Gögenur, I; Reiter, RJ; Rosenberg, J, 2016) |
| "Headache is greatly influenced by the circadian circle." | 2.46 | Headache endocrinological aspects. ( Prieto Peres, MF; Valença, MM, 2010) |
| "Melatonin plays a role in maintaining sleep-wake rhythms; supplementation may help to regulate sleep disturbance that occur with jet lag, rotating shift-work and depression." | 2.44 | Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007) |
| "Headaches due to endocrine diseases in childhood are rare, but any child with chronic headaches should be given serious consideration." | 2.42 | Endocrine aspects of headaches in children and adolescents. ( Weitz, R, 2004) |
| "A pineal cyst is a benign affection of the human pineal gland on the borderline between pathology and normality." | 1.46 | Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection. ( Beneš, V; Bradáč, O; Májovský, M; Netuka, D; Pospíšilová, L; Řezáčová, L; Sumová, A, 2017) |
| "This paper reports a case of hemicrania continua in which attacks were successfully eliminated while taking melatonin 7 mg at bedtime after the patient was no longer able to tolerate indomethacin due to gastrointestinal side effects." | 1.33 | Hemicrania continua: a case in which a patient experienced complete relief on melatonin. ( Spears, RC, 2006) |
| "Hyponic headache syndrome is an unusual chronic headache that usually begins after age 60 years and occurs exclusively during sleep." | 1.31 | Polysomnography in hypnic headache syndrome. ( Dodick, DW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Zduńska, A | 1 |
| Cegielska, J | 1 |
| Domitrz, I | 1 |
| Gelfand, AA | 1 |
| Allen, IE | 1 |
| Grimes, B | 1 |
| Irwin, S | 1 |
| Qubty, W | 1 |
| Greene, K | 1 |
| Waung, M | 1 |
| Powers, SW | 1 |
| Szperka, CL | 1 |
| Burish, MJ | 1 |
| Rozen, TD | 2 |
| Ng, KT | 1 |
| Teoh, WY | 1 |
| Khor, AJ | 1 |
| Peres, MF | 2 |
| Valença, MM | 2 |
| Amaral, FG | 1 |
| Cipolla-Neto, J | 2 |
| Hollingworth, M | 1 |
| Young, TM | 1 |
| Rovers, J | 1 |
| Smits, M | 1 |
| Duffy, JF | 1 |
| Freedom, T | 1 |
| Andersen, LP | 1 |
| Gögenur, I | 1 |
| Rosenberg, J | 1 |
| Reiter, RJ | 1 |
| Májovský, M | 1 |
| Řezáčová, L | 1 |
| Sumová, A | 1 |
| Pospíšilová, L | 1 |
| Netuka, D | 1 |
| Bradáč, O | 1 |
| Beneš, V | 1 |
| Tanuri, FC | 1 |
| de Lima, E | 1 |
| Cabral, FR | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| Zukerman, E | 1 |
| Amado, D | 1 |
| Prieto Peres, MF | 1 |
| Karadaş, O | 1 |
| Ipekdal, IH | 1 |
| Ulaş, UH | 1 |
| Odabaşi, Z | 1 |
| Meyer, S | 1 |
| Oberkircher, N | 1 |
| Böing, A | 1 |
| Larsen, A | 1 |
| Eymann, R | 1 |
| Kutschke, G | 1 |
| Mandera, M | 1 |
| Marcol, W | 1 |
| Bierzyńska-Macyszyn, G | 1 |
| Kluczewska, E | 1 |
| Weitz, R | 1 |
| Spears, RC | 1 |
| Markantonis, SL | 1 |
| Tsakalozou, E | 1 |
| Paraskeva, A | 1 |
| Staikou, C | 1 |
| Fassoulaki, A | 1 |
| Hoang, BX | 1 |
| Shaw, DG | 1 |
| Pham, PT | 1 |
| Levine, SA | 1 |
| Leone, M | 1 |
| Porter, LM | 1 |
| Nagtegaal, JE | 1 |
| Smits, MG | 1 |
| Swart, AC | 1 |
| Kerkhof, GA | 1 |
| van der Meer, YG | 1 |
| Pepping, J | 1 |
| Dodick, DW | 1 |
| Zucconi, M | 1 |
| Bruni, O | 1 |
| Claustrat, B | 1 |
| Brun, J | 1 |
| Chazot, G | 1 |
| Daramola, GF | 1 |
| Olowu, AO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Melatonin and Essential Arterial Hypertension[NCT05257291] | Phase 2 | 23 participants (Actual) | Interventional | 2018-02-02 | Active, not recruiting | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| Innovative Technology for Assessing the Periodontal Disease and New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin[NCT03656484] | Phase 2 | 50 participants (Actual) | Interventional | 2019-01-15 | Completed | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for melatonin and Headache
| Article | Year |
|---|---|
The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research.
Topics: Female; Headache; Humans; Melatonin; Menstrual Cycle; Migraine Disorders; Pineal Gland | 2022 |
Trigeminal Autonomic Cephalalgias.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Headache; Humans; Hypothalamus; In | 2019 |
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.
Topics: Delirium; Dizziness; Headache; Hospital Mortality; Humans; Hypnotics and Sedatives; Incidence; Inden | 2020 |
Current understanding of pineal gland structure and function in headache.
Topics: Adult; Animals; Calcitonin Gene-Related Peptide; Case-Control Studies; Child; Circadian Rhythm; Clin | 2019 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
The Safety of Melatonin in Humans.
Topics: Adolescent; Animals; Child; Dizziness; Headache; Humans; Melatonin; Nausea; Randomized Controlled Tr | 2016 |
Headache endocrinological aspects.
Topics: Animals; Circadian Rhythm; Headache; Headache Disorders; Headache Disorders, Primary; Humans; Melato | 2010 |
Endocrine aspects of headaches in children and adolescents.
Topics: Adolescent; Biomarkers; Child; Endocrine System Diseases; Headache; Humans; Melatonin | 2004 |
Neurobiological effects of melatonin as related to cancer.
Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini | 2007 |
Sleep disorders in children with neurologic diseases.
Topics: Anticonvulsants; Blindness; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Headache; Hu | 2001 |
Melatonin in humans, neuroendocrinological and pharmacological aspects.
Topics: Animals; Circadian Rhythm; Headache; Humans; Light; Melatonin; Mental Disorders; Pineal Gland | 1990 |
3 trials available for melatonin and Headache
| Article | Year |
|---|---|
Melatonin for migraine prevention in children and adolescents: A randomized, double-blind, placebo-controlled trial after single-blind placebo lead-in.
Topics: Adolescent; Adult; Child; Double-Blind Method; Headache; Humans; Melatonin; Migraine Disorders; Sing | 2023 |
Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteers.
Topics: Administration, Oral; Adult; Age Factors; Analysis of Variance; Area Under Curve; Body Mass Index; C | 2008 |
Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations.
Topics: Adolescent; Biological Clocks; Double-Blind Method; Female; Headache; Humans; Male; Melatonin; Middl | 1998 |
15 other studies available for melatonin and Headache
| Article | Year |
|---|---|
Melatonin responsive hemicrania continua in which indomethacin was associated with contralateral headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Female; Headache; Human | 2014 |
Headache and sleep: also assess circadian rhythm sleep disorders.
Topics: Biomarkers; Headache; Humans; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm | 2014 |
Headache and sleep: also assess circadian rhythm sleep disorders: a response.
Topics: Headache; Humans; Melatonin; Saliva; Sleep Disorders, Circadian Rhythm | 2014 |
Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection.
Topics: Adult; Animals; Biomarkers; Brain Neoplasms; Circadian Rhythm; Cysts; Female; Headache; Humans; Hydr | 2017 |
Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Headache; Immunohistochemistry; In | 2009 |
Nocturnal headache associated with melatonin deficiency due to a pineal gland cyst.
Topics: Adult; Circadian Rhythm; Cysts; Headache; Humans; Male; Melatonin; Pineal Gland | 2012 |
Disturbance in melatonin metabolism as a causative factor for recurrent headaches in a girl with a pineal cyst?
Topics: Adolescent; Biomarkers; Brain Diseases; Cysts; Female; Headache; Humans; Melatonin; Pineal Gland | 2013 |
Pineal cysts in childhood.
Topics: Adolescent; alpha-Fetoproteins; Bradycardia; Child; Child, Preschool; Chorionic Gonadotropin, beta S | 2003 |
Melatonin as treatment for idiopathic stabbing headache.
Topics: Adult; Drug Interactions; Female; Headache; Humans; Indomethacin; Melatonin; Middle Aged; Molecular | 2003 |
Hemicrania continua: a case in which a patient experienced complete relief on melatonin.
Topics: Adult; Headache; Humans; Male; Melatonin | 2006 |
Melatonin and primary headache.
Topics: Headache; Humans; Melatonin; Muscle, Smooth, Vascular; Nociceptors; Pineal Gland; Suprachiasmatic Nu | 1994 |
Can melatonin cause severe headaches?
Topics: Adult; Headache; Humans; Male; Melatonin; Self Medication; Sleep Wake Disorders | 1996 |
Melatonin.
Topics: Drug Interactions; Headache; Humans; Jet Lag Syndrome; Melatonin; Neoplasms; Sleep Wake Disorders | 1999 |
Polysomnography in hypnic headache syndrome.
Topics: Aged; Female; Headache; Humans; Indomethacin; Male; Melatonin; Middle Aged; Polysomnography; Recurre | 2000 |
Physiological and radiological implications of a low incidence of pineal calcification in Nigeria.
Topics: Adolescent; Adult; Age Factors; Aged; Calcinosis; Calcium; Child; Child, Preschool; Congenital Abnor | 1972 |