melatonin has been researched along with Headache Disorders in 10 studies
Headache Disorders: Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is increasing evidence that headache disorders are connected with melatonin secretion and pineal function." | 8.83 | Potential therapeutic use of melatonin in migraine and other headache disorders. ( Cavalheiro, EA; Masruha, MR; Moreira-Filho, CA; Peres, MF; Zukerman, E, 2006) |
| "Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment." | 6.43 | Melatonin, the pineal gland and their implications for headache disorders. ( Peres, MF, 2005) |
| "Melatonin intervention has no significant influence on well-being, sleepiness, sleep quality, pain intensity after 1 and 3 hours, headache, depression, and dizziness for laparoscopic cholecystectomy." | 5.01 | The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. ( Wang, Y; Xu, H; Yang, J; Zhang, J, 2019) |
| "There is increasing evidence that headache disorders are connected with melatonin secretion and pineal function." | 4.83 | Potential therapeutic use of melatonin in migraine and other headache disorders. ( Cavalheiro, EA; Masruha, MR; Moreira-Filho, CA; Peres, MF; Zukerman, E, 2006) |
| "Models of sleep physiology and insomnia are discussed, along with the potential implications for the chronification of migraine and tension-type headache." | 2.48 | Chronic headaches and insomnia: working toward a biobehavioral model. ( Ong, JC; Park, M, 2012) |
| "Melatonin is believed to be a significant element in migraine and in other headache disorders, which has implications for treatment." | 2.46 | Headache endocrinological aspects. ( Prieto Peres, MF; Valença, MM, 2010) |
| "Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment." | 2.43 | Melatonin, the pineal gland and their implications for headache disorders. ( Peres, MF, 2005) |
| "Several theories attempt to explain migraine etiology." | 2.41 | The therapeutic potential of melatonin in migraines and other headache types. ( Gagnier, JJ, 2001) |
| "Frequent and recurrent migraine headaches can, over time, pose the additional risks of stroke, brain damage, heart failure and attention deficit." | 1.33 | A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients. ( Eli, R; Fasciano, JA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Wang, Y | 1 |
| Xu, H | 1 |
| Yang, J | 1 |
| Rozen, TD | 2 |
| Beams, JL | 1 |
| Ulas, UH | 1 |
| Korkmaz, A | 1 |
| Karadas, O | 1 |
| Odabasi, Z | 1 |
| Reiter, RJ | 1 |
| Prieto Peres, MF | 1 |
| Valença, MM | 1 |
| Ong, JC | 1 |
| Park, M | 1 |
| Peres, MF | 3 |
| Eli, R | 1 |
| Fasciano, JA | 1 |
| Masruha, MR | 1 |
| Zukerman, E | 1 |
| Moreira-Filho, CA | 1 |
| Cavalheiro, EA | 1 |
| Stiles, MA | 1 |
| Oshinsky, M | 1 |
| Gagnier, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches[NCT00391755] | Phase 4 | 4 participants (Actual) | Interventional | 2006-10-31 | Terminated (stopped due to Failure to recruit necessary number of patients.) | ||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
6 reviews available for melatonin and Headache Disorders
| Article | Year |
|---|---|
The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
Topics: Central Nervous System Depressants; Cholecystectomy, Laparoscopic; Depression; Dizziness; Headache D | 2019 |
Headache endocrinological aspects.
Topics: Animals; Circadian Rhythm; Headache; Headache Disorders; Headache Disorders, Primary; Humans; Melato | 2010 |
Chronic headaches and insomnia: working toward a biobehavioral model.
Topics: Actigraphy; Adaptation, Psychological; Caffeine; Chronobiology Phenomena; Comorbidity; Headache Diso | 2012 |
Melatonin, the pineal gland and their implications for headache disorders.
Topics: Circadian Rhythm; Headache Disorders; Humans; Melatonin; Pineal Gland; Randomized Controlled Trials | 2005 |
Potential therapeutic use of melatonin in migraine and other headache disorders.
Topics: Animals; Headache Disorders; Humans; Melatonin; Migraine Disorders | 2006 |
The therapeutic potential of melatonin in migraines and other headache types.
Topics: Female; Headache Disorders; Humans; Male; Melatonin; Migraine Disorders; Pineal Gland | 2001 |
4 other studies available for melatonin and Headache Disorders
| Article | Year |
|---|---|
A case of post-traumatic LASH syndrome responsive to indomethacin and melatonin (a man with a unique triad of indomethacin-responsive trigeminal autonomic cephalalgias).
Topics: Accidents, Traffic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressan | 2015 |
Sunrise-related headache: case report.
Topics: Adult; Cerebral Infarction; Circadian Rhythm; Cysts; Headache Disorders; Humans; Hypothalamus; Magne | 2010 |
A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients.
Topics: Antioxidants; Headache Disorders; Humans; Hydrocortisone; Melatonin; Migraine Disorders; Moclobemide | 2006 |
Remitting form of hemicrania continua with seasonal pattern.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Headache Disorders; Humans; Indomethacin; Melatonin | 2001 |