melatonin and Genetic Predisposition studies

Research Excerpts

Excerpt	Relevance	Reference
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	7.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"Previous studies suggest that melatonin may act on cancer growth through a variety of mechanisms, most notably by direct anti-proliferative effects on breast cancer cells and via interactions with the estrogen pathway."	7.78	Melatonin pathway genes and breast cancer risk among Chinese women. ( Beeghly-Fadiel, A; Cai, Q; Deming, SL; Gao, YT; Long, J; Lu, W; Shu, XO; Zheng, W; Zheng, Y, 2012)
"In this study we investigated the relationship between melatonin pathway and multiple sclerosis (MS) in a high-risk Finnish population by studying the single nucleotide polymorphisms (SNPs) in the genes coding for critical enzymes and receptors involved in the melatonin pathway."	7.78	Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. ( Einarsdottir, E; Elovaara, I; Hagman, S; Lehtimäki, T; Mononen, N; Natarajan, R; Raunio, M; Riutta, A, 2012)
"Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS)."	7.77	Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. ( Nelson, LM; Ogilvie, JW; Ward, K, 2011)
"Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration."	7.76	Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. ( Bartosz, G; Bieńkiewicz, M; Florkowski, A; Gałecka, E; Gałecki, P; Karbownik-Lewińska, M; Lewiński, A; Szemraj, J, 2010)
"Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease."	5.48	Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018)
"We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms."	4.91	[Circadian markers and genes in bipolar disorder]. ( Belliviera, F; Boudebesse, C; Etain, B; Yeim, S, 2015)
"PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep."	4.90	The relationship between bipolar disorder and biological rhythms. ( Gonzalez, R, 2014)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."	4.40	Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."	4.21	( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; 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"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	3.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"Previous studies suggest that melatonin may act on cancer growth through a variety of mechanisms, most notably by direct anti-proliferative effects on breast cancer cells and via interactions with the estrogen pathway."	3.78	Melatonin pathway genes and breast cancer risk among Chinese women. ( Beeghly-Fadiel, A; Cai, Q; Deming, SL; Gao, YT; Long, J; Lu, W; Shu, XO; Zheng, W; Zheng, Y, 2012)
"In this study we investigated the relationship between melatonin pathway and multiple sclerosis (MS) in a high-risk Finnish population by studying the single nucleotide polymorphisms (SNPs) in the genes coding for critical enzymes and receptors involved in the melatonin pathway."	3.78	Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. ( Einarsdottir, E; Elovaara, I; Hagman, S; Lehtimäki, T; Mononen, N; Natarajan, R; Raunio, M; Riutta, A, 2012)
"Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS)."	3.77	Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. ( Nelson, LM; Ogilvie, JW; Ward, K, 2011)
"Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration."	3.76	Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. ( Bartosz, G; Bieńkiewicz, M; Florkowski, A; Gałecka, E; Gałecki, P; Karbownik-Lewińska, M; Lewiński, A; Szemraj, J, 2010)
"Idiopathic scoliosis is a three-dimensional deformation of the spine."	2.48	Pathogenesis of idiopathic scoliosis: a review. ( Cugy, E; de Sèze, M, 2012)
"The maximum efficacy for jet lag avoidance is by pre-flight adaptation, however, this requires time and commitment."	2.45	Managing jet lag: Some of the problems and possible new solutions. ( Arendt, J, 2009)
"Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity."	1.56	Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism. ( Abel, EA; Mannin, OR; Marceau, K; Schwichtenberg, AJ, 2020)
"The Asian women with TT-genotype and insomnia had a lower levels of melatonin as compared to control at daytime, evening and night."	1.48	Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia. ( Bairova, TA; Kolesnikova, LI; Madaeva, IM; Semenova, NV; Sholokhov, LF; Zhambalova, RM, 2018)
"Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease."	1.48	Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018)
"Melatonin treatment in a human recall-by-genotype study reduced insulin secretion and raised glucose levels more extensively in risk G-allele carriers."	1.43	Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. ( Alenkvist, I; Almgren, P; Asplund, O; Bennet, H; Fadista, J; Fex, M; Forsén, T; Groop, L; Hakaste, L; Isomaa, B; Martikainen, S; Mulder, H; Nagorny, CLF; Östman, B; Pesonen, AK; Räikkönen, K; Shcherbina, L; Singh, P; Söderström, J; Storm, P; Tengholm, A; Tuomi, T; Wierup, N; Yu, Q, 2016)
"Melatonin is a hormone with well-known chronobiotic and hypnotic effects."	1.40	Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014)
"Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior."	1.35	Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008)

Research

Studies (40)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Postoperative Hospital Stay

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (32.50)	29.6817
2010's	22 (55.00)	24.3611
2020's	5 (12.50)	2.80

Authors	Studies
Ocak, Ö	1
Silan, F	1
Şahin, EM	1
Wichert, K	1
Hoppe, R	1
Ickstadt, K	1
Behrens, T	1
Winter, S	1
Herold, R	1
Terschüren, C	1
Lo, WY	1
Guénel, P	1
Truong, T	1
Bolla, MK	1
Wang, Q	1
Dennis, J	1
Michailidou, K	1
Lush, M	1
Andrulis, IL	1
Brenner, H	1
Chang-Claude, J	1
Cox, A	1
Cross, SS	1
Czene, K	1
Eriksson, M	1
Figueroa, JD	1
García-Closas, M	1
Goldberg, MS	1
Hamann, U	1
He, W	1
Holleczek, B	1
Hopper, JL	1
Jakubowska, A	1
Ko, YD	1
Lubiński, J	1
Mulligan, AM	1
Obi, N	1
Rhenius, V	1
Shah, M	1
Shu, XO	2
Simard, J	1
Southey, MC	1
Zheng, W	2
Dunning, AM	1
Pharoah, PDP	1
Hall, P	1
Easton, DF	1
Brüning, T	1
Brauch, H	1
Harth, V	1
Rabstein, S	1
Wang, P	1
Liu, L	4
Zhao, LF	1
Zhao, CN	1
Mao, YM	1
Dan, YL	1
Wu, Q	1
Li, XM	1
Wang, DG	1
Pan, HF	1
Nese, M	1
Riboli, G	1
Brighetti, G	1
Sassi, V	1
Camela, E	1
Caselli, G	1
Sassaroli, S	1
Borlimi, R	1
Aucoin, M	1
Cooley, K	1
Saunders, PR	1
Carè, J	1
Anheyer, D	1
Medina, DN	1
Cardozo, V	1
Remy, D	1
Hannan, N	1
Garber, A	1
Velayos, M	1
Muñoz-Serrano, AJ	1
Estefanía-Fernández, K	1
Sarmiento Caldas, MC	1
Moratilla Lapeña, L	1
López-Santamaría, M	1
López-Gutiérrez, JC	1
Li, J	1
Zhang, J	1
Shen, S	1
Zhang, B	2
Yu, WW	1
Toyoda, H	1
Huang, DQ	1
Le, MH	1
Nguyen, MH	1
Huang, R	1
Zhu, L	1
Wang, J	6
Xue, L	1
Yan, X	2
Huang, S	1
Li, Y	6
Xu, T	1
Li, C	2
Ji, F	1
Ming, F	1
Zhao, Y	2
Cheng, J	1
Wang, Y	3
Zhao, H	1
Hong, S	1
Chen, K	2
Zhao, XA	1
Zou, L	1
Sang, D	1
Shao, H	1
Guan, X	1
Chen, X	2
Chen, Y	4
Wei, J	1
Zhu, C	1
Wu, C	1
Moore, HB	1
Barrett, CD	1
Moore, EE	1
Jhunjhunwala, R	1
McIntyre, RC	1
Moore, PK	1
Hajizadeh, N	1
Talmor, DS	1
Sauaia, A	1
Yaffe, MB	1
Liu, C	3
Lin, Y	1
Dong, Y	1
Wu, Y	1
Bao, Y	1
Yan, H	2
Ma, J	1
Fernández-Cuadros, ME	1
Albaladejo-Florín, MJ	1
Álava-Rabasa, S	1
Usandizaga-Elio, I	1
Martinez-Quintanilla Jimenez, D	1
Peña-Lora, D	1
Neira-Borrajo, I	1
López-Muñoz, MJ	1
Rodríguez-de-Cía, J	1
Pérez-Moro, OS	1
Abdallah, M	1
Alsaleh, H	1
Baradwan, A	1
Alfawares, R	1
Alobaid, A	1
Rasheed, A	1
Soliman, I	1
Wendel Garcia, PD	1
Fumeaux, T	1
Guerci, P	1
Heuberger, DM	1
Montomoli, J	2
Roche-Campo, F	1
Schuepbach, RA	1
Hilty, MP	1
Poloni, TE	1
Carlos, AF	1
Cairati, M	1
Cutaia, C	1
Medici, V	1
Marelli, E	1
Ferrari, D	1
Galli, A	1
Bognetti, P	1
Davin, A	1
Cirrincione, A	1
Ceretti, A	1
Cereda, C	1
Ceroni, M	1
Tronconi, L	1
Vitali, S	1
Guaita, A	1
Leeds, JS	1
Raviprakash, V	1
Jacques, T	1
Scanlon, N	1
Cundall, J	1
Leeds, CM	1
Riva, A	1
Gray, EH	1
Azarian, S	1
Zamalloa, A	1
McPhail, MJW	1
Vincent, RP	1
Williams, R	1
Chokshi, S	1
Patel, VC	1
Edwards, LA	1
Alqarawi, W	1
Birnie, DH	1
Golian, M	1
Nair, GM	1
Nery, PB	1
Klein, A	1
Davis, DR	1
Sadek, MM	1
Neilipovitz, D	1
Johnson, CB	1
Green, MS	1
Redpath, C	1
Miller, DC	1
Beamer, P	1
Billheimer, D	1
Subbian, V	1
Sorooshian, A	1
Campbell, BS	1
Mosier, JM	1
Novaretti, JV	1
Astur, DC	1
Cavalcante, ELB	1
Kaleka, CC	1
Amaro, JT	1
Cohen, M	1
Huang, W	1
Li, T	1
Ling, Y	1
Qian, ZP	1
Zhang, YY	1
Huang, D	1
Xu, SB	1
Liu, XH	1
Xia, L	1
Yang, Y	3
Lu, SH	1
Lu, HZ	1
Zhang, R	2
Ma, JX	1
Tang, S	1
Li, CM	1
Wan, J	1
Wang, JF	1
Ma, JQ	1
Luo, JJ	1
Chen, HY	2
Mi, SL	1
Chen, SY	1
Su, YG	1
Ge, JB	1
Milheiro, SA	1
Gonçalves, J	1
Lopes, RMRM	1
Madureira, M	1
Lobo, L	1
Lopes, A	1
Nogueira, F	1
Fontinha, D	1
Prudêncio, M	1
M Piedade, MF	1
Pinto, SN	1
Florindo, PR	1
Moreira, R	1
Castillo-Lora, J	1
Delley, MF	1
Laga, SM	1
Mayer, JM	1
Sutjarit, N	1
Thongon, N	1
Weerachayaphorn, J	1
Piyachaturawat, P	1
Suksamrarn, A	1
Suksen, K	1
Papachristou, DJ	1
Blair, HC	1
Hu, Y	1
Shen, P	1
Zeng, N	1
Wang, L	4
Yan, D	1
Cui, L	1
Yang, K	2
Zhai, C	1
Yang, M	1
Lao, X	1
Sun, J	1
Ma, N	1
Wang, S	2
Ye, W	1
Guo, P	1
Rahimi, S	1
Singh, MP	1
Gupta, J	1
Nakanishi, I	1
Ohkubo, K	1
Shoji, Y	1
Fujitaka, Y	1
Shimoda, K	1
Matsumoto, KI	1
Fukuhara, K	1
Hamada, H	1
van der Boom, T	1
Gruppen, EG	1
Lefrandt, JD	1
Connelly, MA	1
Links, TP	1
Dullaart, RPF	1
Berry, JD	1
Bedlack, R	1
Mathews, D	1
Agnese, W	1
Apple, S	1
Meloncelli, S	1
Divizia, M	1
Germani, G	1
Adefegha, SA	1
Bottari, NB	1
Leal, DB	1
de Andrade, CM	1
Schetinger, MR	1
Martínez-Velasco, A	1
Perez-Ortiz, AC	1
Antonio-Aguirre, B	1
Martínez-Villaseñor, L	1
Lira-Romero, E	1
Palacio-Pastrana, C	1
Zenteno, JC	1
Ramirez, I	1
Zepeda-Palacio, C	1
Mendoza-Velásquez, C	1
Camacho-Ordóñez, A	1
Ortiz Bibriesca, DM	1
Estrada-Mena, FJ	1
Martin, BL	1
Thompson, LC	1
Kim, YH	2
Snow, SJ	1
Schladweiler, MC	1
Phillips, P	1
Harmon, M	1
King, C	1
Richards, J	1
George, I	1
Haykal-Coates, N	1
Gilmour, MI	1
Kodavanti, UP	1
Hazari, MS	1
Farraj, AK	1
Shen, Z	1
Zou, Y	1
Gao, K	1
Lazar, S	1
Wurtzel, JGT	1
Ma, P	1
Goldfinger, LE	1
Vukelic, M	1
Laloo, A	1
Kyttaris, VC	1
Chen, R	1
Chen, J	2
Xun, J	1
Hu, Z	1
Huang, Q	2
Steinhart, C	1
Shen, Y	2
Lu, H	1
Mansuri, A	1
Lokhande, K	1
Kore, S	1
Gaikwad, S	1
Nawani, N	1
Swamy, KV	1
Junnarkar, M	1
Pawar, S	1
Shaheen, MY	1
Basudan, AM	1
Niazy, AA	1
van den Beucken, JJJP	1
Jansen, JA	1
Alghamdi, HS	1
Gao, Q	2
Guo, X	2
Cao, Y	1
Jia, X	1
Xu, S	1
Lu, C	2
Zhu, H	2
Melku, M	1
Abebe, G	1
Teketel, A	1
Asrie, F	1
Yalew, A	1
Biadgo, B	1
Kassa, E	1
Damtie, D	1
Anlay, DZ	1
Ahmed, MFE	1
Ramadan, H	1
Seinige, D	1
Kehrenberg, C	1
Abd El-Wahab, A	1
Volkmann, N	1
Kemper, N	1
Schulz, J	1
Hu, MY	1
Wu, YN	1
McEvoy, MP	1
Wang, YF	1
Cong, WL	1
Liu, LP	1
Li, XX	1
Zhou, CL	1
Chen, WM	1
Wei, KL	1
Tung, SY	1
Shen, CH	1
Chang, TS	1
Yen, CW	1
Hsieh, YY	1
Chiu, WN	1
Hu, JH	1
Lu, SN	1
Hung, CH	1
Alakavuklar, MA	1
Fuqua, C	1
Luo, KL	1
Underwood, RS	1
Greenwald, I	1
Elashiry, MM	1
Elashiry, M	1
Zeitoun, R	1
Elsayed, R	1
Tian, F	1
Saber, SE	1
Elashry, SH	1
Tay, FR	1
Cutler, CW	1
O'Dowd, A	1
Maciel, M	1
Poole, ST	1
Jobling, MG	1
Rollenhagen, JE	1
Woods, CM	1
Sincock, SA	1
McVeigh, AL	1
Gregory, MJ	1
Maves, RC	1
Prouty, MG	1
Holmes, RK	1
Savarino, SJ	1
Mor, MK	1
Palevsky, PM	1
Kaufman, JS	1
Thiessen Philbrook, H	1
Weisbord, SD	1
Parikh, CR	1
John, CM	1
Phillips, NJ	1
Jarvis, GA	1
Zhu, Y	1
Kilburn, S	1
Kapoor, M	1
Chaturvedi, S	1
Shaw, KJ	1
Chaturvedi, V	1
Kong, X	1
Zhang, T	1
Xiao, H	1
Feng, X	1
Tu, H	1
Feng, J	1
Sabet, M	1
Tarazi, Z	1
Griffith, DC	1
Nguyen, F	1
Guan, P	1
Guerrero, DT	1
Kolla, V	1
Naraparaju, K	1
Perry, LM	1
Soberman, D	1
Pressly, BB	1
Alferiev, IS	1
Chorny, M	1
Brodeur, GM	1
Gao, X	2
Cheng, YH	1
Enten, GA	1
DeSantis, AJ	1
Gaponenko, V	1
Majetschak, M	1
Kim, DY	1
Choi, MJ	1
Ko, TK	1
Lee, NH	1
Kim, OH	1
Cheon, HG	1
Cai, H	1
Yip, V	1
Lee, MV	1
Wong, S	1
Saad, O	1
Ma, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054]		50 participants (Anticipated)	Observational	2017-03-15	Enrolling by invitation
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599]	Phase 2	86 participants (Actual)	Interventional	2016-07-31	Completed
Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702]		35 participants (Anticipated)	Observational	2017-03-29	Enrolling by invitation
Does Melatonin Treatment Affect Glucose Tolerance Among Individuals With a Variant (rs10830963) of the Melatonin Receptor 1B (MTNR1B) Gene?[NCT01705639]	Phase 3	45 participants (Actual)	Interventional	2012-11-30	Completed
Scoliosis Patients Aged 10-13 Years: Monitoring of Scoliosis by the Surface Topography[NCT02531945]		125 participants (Actual)	Interventional	2015-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Changes in C-reactive Protein (CRP) Levels

Intervention	days (Median)
Morphine	7
Levobupivacaine	7

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Cognitive Function

Intervention	mg/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	57.8	98.1	95	54.6
Morphine	57.2	106.2	118.5	66.9

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

Changes in Fibrinogen Concentrations in Peripheral Blood

Intervention	score on a scale (Median)
	Before surgery	24 h after surgery	48 h after surgery	72 h after surgery	96 h after surgery	120 h after surgery
Levobupivacaine	22	22	21	21	21	22
Morphine	21	20	20	20	20	20

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Pain Intensity

Intervention	g/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	4.5	4.7	5.2	5
Morphine	5.5	5.3	5.7	5.4

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

Interleukin-6 Concentration in Peripheral Blood.

Intervention	score on a scale (Median)
	3,6,9,12,15,18,21 and 24h after surgery	27,30,33,36,39,42,45 and 48h after surgery	51,54,57,60,63,66,69 and 72h after surgery	4. postoperative day (every 8 hours)	5. postoperative day (every 8 hours)	6. postoperative day (every 8 hours)	Day of discharge
Levobupivacaine	0.6	0.5	0.5	0.3	0	0	0
Morphine	1.4	1.5	1.4	1.4	1.4	1.3	1

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

Article	Year
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. Science & sports, 2023, Apr-04 Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp	2023
Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2 Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;	2022
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease. Cellular and molecular life sciences : CMLS, 2017, Volume: 74, Issue:20 Topics: alpha-Synuclein; Animals; Circadian Clocks; Dopamine; Dopaminergic Neurons; Genetic Predisposition t	2017
Smith-Magenis Syndrome: Molecular Basis of a Genetic-Driven Melatonin Circadian Secretion Disorder. International journal of molecular sciences, 2019, Jul-19, Volume: 20, Issue:14 Topics: Animals; Chromosome Mapping; Circadian Rhythm; Disease Susceptibility; Genetic Predisposition to Dis	2019
The relationship between bipolar disorder and biological rhythms. The Journal of clinical psychiatry, 2014, Volume: 75, Issue:4 Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Genetic Predisposition to Disease; Huma	2014
[Circadian markers and genes in bipolar disorder]. L'Encephale, 2015, Volume: 41, Issue:4 Suppl 1 Topics: Biomarkers; Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Gene Expression Regulation;	2015
Managing jet lag: Some of the problems and possible new solutions. Sleep medicine reviews, 2009, Volume: 13, Issue:4 Topics: Adaptation, Physiological; Circadian Rhythm; Combined Modality Therapy; Genetic Predisposition to Di	2009
[Molecular and genetic aspects of idiopathic scoliosis. Blood test for idiopathic scoliosis]. Der Orthopade, 2009, Volume: 38, Issue:2 Topics: Biomarkers; Blood Chemical Analysis; Genetic Predisposition to Disease; Humans; Mass Screening; Mela	2009
Pathogenesis of idiopathic scoliosis: a review. Annals of physical and rehabilitation medicine, 2012, Volume: 55, Issue:2 Topics: Adolescent; Animals; Biomechanical Phenomena; Bone Development; Calmodulin; Child; Disease Models, A	2012
Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. Human molecular genetics, 2012, Sep-15, Volume: 21, Issue:18 Topics: Acetylserotonin O-Methyltransferase; Bipolar Disorder; Case-Control Studies; Cells, Cultured; DNA Mu	2012
Diagnosis and treatment of autism spectrum disorders. Current problems in pediatric and adolescent health care, 2003, Volume: 33, Issue:9 Topics: Adrenergic Agents; Anticonvulsants; Autistic Disorder; Child; Genetic Predisposition to Disease; Hum	2003

Article	Year
Melatonin receptor gene polymorphisms as a risk factor in patients with diabetic peripheral neuropathy. Diabetes/metabolism research and reviews, 2022, Volume: 38, Issue:8 Topics: Diabetes Mellitus; Diabetic Neuropathies; Genetic Predisposition to Disease; Humans; Melatonin; Poly	2022
Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. European journal of epidemiology, 2023, Volume: 38, Issue:10 Topics: Bayes Theorem; Breast Neoplasms; Case-Control Studies; Female; Genetic Predisposition to Disease; Hu	2023
Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population. Journal of immunology research, 2019, Volume: 2019 Topics: Adult; Arylalkylamine N-Acetyltransferase; Asian People; Case-Control Studies; Female; Gene Expressi	2019
Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia. Chronobiology international, 2018, Volume: 35, Issue:8 Topics: Asian People; Circadian Rhythm; CLOCK Proteins; Female; Gene Frequency; Genetic Predisposition to Di	2018
Melatonin receptor type 1A gene linked to Alzheimer's disease in old age. Sleep, 2018, 07-01, Volume: 41, Issue:7 Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brain;	2018
Melatonin: A hypothesis for Kawasaki disease treatment. Medical hypotheses, 2018, Volume: 119 Topics: Anti-Inflammatory Agents; Aspirin; Child; Child, Preschool; Communicable Diseases; Genetic Predispos	2018
Salivary melatonin onset in youth at familial risk for bipolar disorder. Psychiatry research, 2019, Volume: 274 Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Child; Circadian Rhythm; Female; Genetic Predisposi	2019
Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism. Journal of autism and developmental disorders, 2020, Volume: 50, Issue:5 Topics: Autism Spectrum Disorder; Autistic Disorder; Circadian Rhythm; Comorbidity; Databases, Genetic; Dopa	2020
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Lack of association of the NPAS2 gene Ala394Thr polymorphism (rs2305160:G>A) with risk of chronic lymphocytic leukemia. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:17 Topics: Aged; Asian People; Basic Helix-Loop-Helix Transcription Factors; Case-Control Studies; Female; Gene	2014
Genetic association study of circadian genes with seasonal pattern in bipolar disorders. Scientific reports, 2015, May-19, Volume: 5 Topics: Adult; Basic Helix-Loop-Helix Transcription Factors; Bipolar Disorder; Circadian Clocks; Circadian R	2015
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. Cell metabolism, 2016, 06-14, Volume: 23, Issue:6 Topics: Animals; Cyclic AMP; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glucose; Heterozy	2016
A Wake-up Call for Type 2 Diabetes? The New England journal of medicine, 2016, Sep-15, Volume: 375, Issue:11 Topics: Animals; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genetic Variation; Humans; In	2016
Circadian rhythm disorders in pediatrics. Pediatric annals, 2008, Volume: 37, Issue:7 Topics: Adolescent; Child; Circadian Rhythm; Genetic Predisposition to Disease; Health Behavior; Humans; Mal	2008
Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. Journal of pineal research, 2010, Volume: 48, Issue:2 Topics: Asian People; China; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease;	2010
Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. Journal of pineal research, 2010, Volume: 48, Issue:4 Topics: Acetylserotonin O-Methyltransferase; Adult; Chi-Square Distribution; Depressive Disorder; Female; Ge	2010
Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. Spine, 2011, Jan-01, Volume: 36, Issue:1 Topics: Acetylserotonin O-Methyltransferase; Adolescent; Arylalkylamine N-Acetyltransferase; Case-Control St	2011
No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study. Diabetologia, 2011, Volume: 54, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type	2011
Melatonin pathway genes and breast cancer risk among Chinese women. Breast cancer research and treatment, 2012, Volume: 132, Issue:2 Topics: Adult; Age Factors; Arylalkylamine N-Acetyltransferase; Asian People; Breast Neoplasms; Case-Control	2012
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. Journal of neuroimmunology, 2012, Sep-15, Volume: 250, Issue:1-2 Topics: Case-Control Studies; Disability Evaluation; Female; Finland; Genetic Predisposition to Disease; Gen	2012
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics, 2003, Volume: 4, Issue:3 Topics: Alleles; Amino Acid Motifs; Amino Acid Substitution; Arylamine N-Acetyltransferase; Binding Sites; C	2003
[Impulse activity of neurons in the lateral hypothalamus during microionophoretic administration of melatonin and noradrenaline in rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2002, Volume: 88, Issue:12 Topics: Action Potentials; Animals; Behavior, Animal; Genetic Predisposition to Disease; Hypothalamic Area,	2002
Melatonin sensitivity to light in monozygotic twins discordant for bipolar I disorder. The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:10 Topics: Adult; Biomarkers; Bipolar Disorder; Female; Genetic Predisposition to Disease; Humans; Melatonin; P	2005
Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating. Brain research bulletin, 2006, Feb-15, Volume: 68, Issue:6 Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Depressive Disorder; Female; Genetic Predispositi	2006
Genetically increased risk of sleep disruption in Alzheimer's disease. Sleep, 2006, Volume: 29, Issue:8 Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Base Pairing; Case-Control S	2006
A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimer's disease patients. Brain research, 2007, Sep-05, Volume: 1167 Topics: Aged; Alzheimer Disease; Biogenic Monoamines; DNA Mutational Analysis; Female; Gene Expression Regul	2007
Exacerbated mechanical allodynia in rats with depression-like behavior. Brain research, 2008, Mar-20, Volume: 1200 Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu	2008
Melatonin, psoralens, and the genetic basis of seasonal affective disorder and seasonality. Medical hypotheses, 2000, Volume: 54, Issue:2 Topics: Female; Furocoumarins; Genetic Predisposition to Disease; Humans; Male; Melatonin; Seasonal Affectiv	2000
Melatonin suppression by light in euthymic bipolar and unipolar patients. Archives of general psychiatry, 2000, Volume: 57, Issue:6 Topics: Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female;	2000

melatonin and Genetic Predisposition