melatonin has been researched along with Gastric Ulcer in 51 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin (MT) and its precursor L-tryptophan (TRP) are implicated in the protection of gastric mucosa against aspirin-induced lesions and in the acceleration of healing of idiopathic gastro-duodenal ulcers, but no information is available whether these agents are also effective in healing of gastroduodenal ulcers accompanied by Helicobacter pylori (H." | 9.15 | Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. ( Bielanski, W; Brzozowski, T; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Slomka, M, 2011) |
| " Recent findings, presented in this review, provide evidence that melatonin prevents the formation of acute gastric lesions induced by stress and accelerates healing of chronic gastric ulcers due to increase in the activity of nitric oxide (NO) synthase (NOS)-NO and cyclooxygenase (COX)-prostaglandin E(2) (PGE(2)) systems resulting in the increase of mucosal blood flow and mucosal integrity." | 8.83 | Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. ( Brzozowski, T; Konturek, PC; Konturek, SJ, 2006) |
| "This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin." | 8.12 | Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 7.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| " We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers." | 7.76 | Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010) |
| "Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs." | 7.70 | Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs. ( Ayles, HL; Ball, RO; Brown, GM; Bubenik, GA; Friendship, RM, 1998) |
| " A number of excellent drugs, developed over the decades, have proven useful in controlling hyperacidity and ulceration although their long-term use is reported to be associated with various side effects." | 6.43 | Reactive oxygen species-induced gastric ulceration: protection by melatonin. ( Bandyopadhyay, D; Chattopadhyay, A, 2006) |
| "Melatonin (MT) is an ubiquitous molecule, representing one of the phylogenetically oldest signaling mechanisms." | 5.35 | Tryptophan free diet delays healing of chronic gastric ulcers in rat. ( Brzozowski, T; Burnat, G; Konturek, PC; Konturek, SJ; Zopf, Y, 2008) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 5.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| " The current studies, therefore, document melatonin's gastroprotective ability against piroxicam-induced gastric damage and the findings raise the possibility of melatonin being considered as a co-therapy with piroxicam or other NSAIDs in reducing the gastropathy when long-term use of these nonsteroidal agents are unavoidable." | 5.32 | Melatonin protects against piroxicam-induced gastric ulceration. ( Bandyopadhyay, A; Bandyopadhyay, D; Ghosh, G; Reiter, RJ, 2004) |
| "Melatonin (MT) and its precursor L-tryptophan (TRP) are implicated in the protection of gastric mucosa against aspirin-induced lesions and in the acceleration of healing of idiopathic gastro-duodenal ulcers, but no information is available whether these agents are also effective in healing of gastroduodenal ulcers accompanied by Helicobacter pylori (H." | 5.15 | Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. ( Bielanski, W; Brzozowski, T; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Slomka, M, 2011) |
| " Recent findings, presented in this review, provide evidence that melatonin prevents the formation of acute gastric lesions induced by stress and accelerates healing of chronic gastric ulcers due to increase in the activity of nitric oxide (NO) synthase (NOS)-NO and cyclooxygenase (COX)-prostaglandin E(2) (PGE(2)) systems resulting in the increase of mucosal blood flow and mucosal integrity." | 4.83 | Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. ( Brzozowski, T; Konturek, PC; Konturek, SJ, 2006) |
| "This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin." | 4.12 | Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022) |
| " Sterile tissue injury of either skin injury or gastric ulceration was induced in equal numbers in Wistar albino rats aged 7-8 weeks (150-200 g) (20 each), with each group being equally divided into melatonin treated or vehicle-treated." | 3.79 | Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats. ( Al-Ani, B; Sakr, HF, 2013) |
| "The gastroprotective action of synthetic dipeptides glutamyl-tryptophane (EW), iso-valeroyl-glutamyl-tryptophane (ivEW) and nicotinoyl-glutamyl-tryptophane (nEW) in comparison to melatonin was studied in experiments on male with the model indometacine and starvation stress-induced stomach ulcers." | 3.78 | [Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin]. ( Malinin, VV; Savateeva-Liubimova, TN; Sivak, KV, 2012) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 3.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| " We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers." | 3.76 | Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010) |
| "All inflammation parameters were increased by acetic acid-induced colitis or ethanol-induced gastric ulcer compared with the control group." | 3.73 | Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes. ( Cevík, H; Ercan, F; Erkanli, G; Işman, CA; Yeğen, BC, 2005) |
| ") administration of melatonin and its precursor, L-tryptophan, with or without concurrent treatment with luzindole, a selective antagonist of melatonin MT2 receptors, on healing of chronic gastric ulcers induced by serosal application of acetic acid (ulcer area 28 mm2)." | 3.71 | Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. ( Brzozowska, I; Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R; Pawlik, M; Ptak, A, 2002) |
| "Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs." | 3.70 | Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs. ( Ayles, HL; Ball, RO; Brown, GM; Bubenik, GA; Friendship, RM, 1998) |
| "Melatonin was thought to originate primarily from the pineal gland and to be secreted during the night, but recent studies revealed that gastrointestinal (GI) tract presents another, many times larger, source of melatonin that contributes significantly to the circulating concentration of this indole." | 2.43 | Melatonin as an organoprotector in the stomach and the pancreas. ( Brzozowski, T; Jaworek, J; Konturek, SJ, 2005) |
| " A number of excellent drugs, developed over the decades, have proven useful in controlling hyperacidity and ulceration although their long-term use is reported to be associated with various side effects." | 2.43 | Reactive oxygen species-induced gastric ulceration: protection by melatonin. ( Bandyopadhyay, D; Chattopadhyay, A, 2006) |
| " A number of excellent drugs have proven useful in controlling hyperacidity and ulceration but their long-term use is associated with disturbing side-effects." | 2.41 | Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. ( Bandyopadhyay, D; Banerjee, RK; Bhattacharyya, M; Biswas, K; Reiter, RJ, 2001) |
| "Pretreatment with melatonin or tryptophan remarkably reduced ASA induced gastric lesions and microbleeding." | 1.36 | Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans. ( Bielanski, W; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Reiter, RJ; Slomka, M, 2010) |
| "Melatonin (MT) is an ubiquitous molecule, representing one of the phylogenetically oldest signaling mechanisms." | 1.35 | Tryptophan free diet delays healing of chronic gastric ulcers in rat. ( Brzozowski, T; Burnat, G; Konturek, PC; Konturek, SJ; Zopf, Y, 2008) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 1.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing." | 1.35 | Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009) |
| "1." | 1.35 | Melatonin protects against hydrogen peroxide-induced gastric injury in rats. ( Abdel-Naim, AB; Alahdal, AM; Ashour, OM; El-Sherbeny, NA; Mohamadin, AM; Morsy, GM, 2009) |
| "No gastric ulcers were found in passive animals kept under shifted light-dark cycle." | 1.32 | Desynchronosis and erosive and ulcerative lesions of the stomach in rats active or passive in the open-field test: effect of exogenous melatonin. ( Pertsov, SS, 2003) |
| " The current studies, therefore, document melatonin's gastroprotective ability against piroxicam-induced gastric damage and the findings raise the possibility of melatonin being considered as a co-therapy with piroxicam or other NSAIDs in reducing the gastropathy when long-term use of these nonsteroidal agents are unavoidable." | 1.32 | Melatonin protects against piroxicam-induced gastric ulceration. ( Bandyopadhyay, A; Bandyopadhyay, D; Ghosh, G; Reiter, RJ, 2004) |
| "pretreatment with indomethacin at 5 mg/kg." | 1.30 | Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats. ( Arakawa, Y; Asai, S; Ishikawa, K; Iwasaki, A; Kaneda, N; Kato, K; Komuro, S; Kuwayama, H; Matsuno, Y; Murai, I; Nakagawa, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.96) | 18.7374 |
| 1990's | 10 (19.61) | 18.2507 |
| 2000's | 26 (50.98) | 29.6817 |
| 2010's | 11 (21.57) | 24.3611 |
| 2020's | 3 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Choudhary, P | 1 |
| Roy, T | 1 |
| Chatterjee, A | 1 |
| Mishra, VK | 1 |
| Pant, S | 1 |
| Swarnakar, S | 8 |
| Zagajewski, J | 1 |
| Wojcik-Grzybek, D | 1 |
| Brzozowski, B | 1 |
| Majka, J | 2 |
| Magierowski, M | 2 |
| Placha, W | 1 |
| Lasota, M | 1 |
| Laidler, PM | 1 |
| Brzozowski, T | 12 |
| Majumder, R | 1 |
| Datta, M | 1 |
| Banerjee, A | 2 |
| Bandyopadhyay, D | 5 |
| Chattopadhyay, A | 2 |
| Zuev, VA | 1 |
| Trifonov, NI | 1 |
| Linkova, NS | 1 |
| Kvetnaia, TV | 1 |
| Sakr, HF | 1 |
| Al-Ani, B | 1 |
| Jasnos, K | 1 |
| Brzozowska, I | 5 |
| Drozdowicz, D | 4 |
| Sliwowski, Z | 3 |
| Nawrot, E | 1 |
| Szczyrk, U | 1 |
| Kwiecień, S | 3 |
| Abdelraheim, SR | 1 |
| Okasha, AM | 1 |
| Ghany, HM | 1 |
| Ibrahim, HM | 1 |
| Arushanian, ÉB | 1 |
| Beĭer, ÉV | 1 |
| Konturek, PC | 13 |
| Celinski, K | 3 |
| Slomka, M | 3 |
| Cichoz-Lach, H | 3 |
| Burnat, G | 3 |
| Naegel, A | 1 |
| Bielanski, W | 5 |
| Konturek, JW | 1 |
| Konturek, SJ | 14 |
| Zopf, Y | 1 |
| Mohamadin, AM | 1 |
| Ashour, OM | 1 |
| El-Sherbeny, NA | 1 |
| Alahdal, AM | 1 |
| Morsy, GM | 1 |
| Abdel-Naim, AB | 1 |
| Colucci, R | 1 |
| Fornai, M | 1 |
| Antonioli, L | 1 |
| Ghisu, N | 1 |
| Tuccori, M | 1 |
| Blandizzi, C | 1 |
| Del Tacca, M | 1 |
| Ganguly, K | 6 |
| Reiter, RJ | 9 |
| Sharma, AV | 2 |
| Pradeepkumar Singh, L | 1 |
| Vivek Sharma, A | 1 |
| Savateeva-Liubimova, TN | 1 |
| Sivak, KV | 1 |
| Malinin, VV | 1 |
| Biswas, K | 2 |
| Bhattacharyya, M | 2 |
| Banerjee, RK | 2 |
| Pertsov, SS | 3 |
| Abdel-Salam, OM | 1 |
| Baiuomy, AR | 1 |
| El-batran, S | 1 |
| Arbid, MS | 1 |
| Ghosh, G | 1 |
| Bandyopadhyay, A | 1 |
| Cevík, H | 1 |
| Erkanli, G | 1 |
| Ercan, F | 1 |
| Işman, CA | 1 |
| Yeğen, BC | 1 |
| Jaworek, J | 1 |
| Maity, P | 1 |
| Zwirska-Korczala, K | 3 |
| Pawlik, M | 3 |
| Pawlik, WW | 2 |
| Hahn, EG | 5 |
| Kundu, P | 1 |
| Mishra, A | 1 |
| Mazurkiewicz-Janik, M | 1 |
| Zembala, M | 2 |
| Dembinski, A | 1 |
| Mytar, B | 1 |
| De La Lastra, CA | 1 |
| Cabeza, J | 2 |
| Motilva, V | 2 |
| Martin, MJ | 2 |
| Pajdo, R | 2 |
| Stachura, J | 1 |
| Bubenik, GA | 1 |
| Ayles, HL | 1 |
| Friendship, RM | 1 |
| Brown, GM | 1 |
| Ball, RO | 1 |
| Sosnovskiĭ, AS | 2 |
| Pirogova, GV | 1 |
| Kato, K | 3 |
| Murai, I | 3 |
| Asai, S | 3 |
| Matsuno, Y | 1 |
| Komuro, S | 2 |
| Kaneda, N | 1 |
| Iwasaki, A | 3 |
| Ishikawa, K | 2 |
| Nakagawa, S | 1 |
| Arakawa, Y | 3 |
| Kuwayama, H | 1 |
| Alarcón de la Lastra, C | 1 |
| Nieto, A | 1 |
| Barranco, MD | 1 |
| Herrerías, JM | 1 |
| Komarov, FI | 1 |
| Rapoport, SI | 1 |
| Malinovskaia, NK | 1 |
| Sudakov, KV | 1 |
| Wetterberg, L | 1 |
| Otsuka, M | 1 |
| Sener-Muratoğlu, G | 1 |
| Paskaloğlu, K | 1 |
| Arbak, S | 1 |
| Hürdağ, C | 1 |
| Ayanoğlu-Dülger, G | 1 |
| Takahashi, Y | 1 |
| Nagata, T | 1 |
| Mizuno, S | 1 |
| Ptak, A | 1 |
| Ratner, GL | 1 |
| Kvetnoĭ, IM | 1 |
| Bereslavskiĭ, MI | 1 |
| Margolis, IaM | 1 |
| Vaĭsman, BL | 1 |
| Khan, R | 1 |
| Burton, S | 1 |
| Morley, S | 1 |
| Daya, S | 1 |
| Potgieter, B | 1 |
| Cho, CH | 1 |
| Pang, SF | 1 |
| Chen, BW | 1 |
| Pfeiffer, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Circadian Misalignment as a Disease Risk Factor in Inflammatory Bowel Disease[NCT04637399] | 52 participants (Actual) | Observational | 2016-11-22 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for melatonin and Gastric Ulcer
| Article | Year |
|---|---|
[Melatonin as a molecular marker of age-related pathologies].
Topics: Age Factors; Alzheimer Disease; Biomarkers; Circadian Rhythm; Enterocytes; Humans; Melatonin; Mouth | 2017 |
Involvement of reactive oxygen species in gastric ulceration: protection by melatonin.
Topics: Animals; Anti-Ulcer Agents; Free Radical Scavengers; Gastric Mucosa; Humans; Melatonin; Reactive Oxy | 2002 |
Melatonin as an organoprotector in the stomach and the pancreas.
Topics: Animals; Humans; Melatonin; Pancreas; Pancreatitis; Stomach; Stomach Ulcer | 2005 |
Reactive oxygen species-induced gastric ulceration: protection by melatonin.
Topics: Animals; Anti-Ulcer Agents; Gastric Juice; Humans; Melatonin; Reactive Oxygen Species; Stomach Ulcer | 2006 |
Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers.
Topics: Animals; Cyclooxygenase 2; Dinoprostone; Humans; Melatonin; Nitric Oxide Synthase Type II; Stomach U | 2006 |
Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin.
Topics: Animals; Anti-Ulcer Agents; Gastric Mucosa; Humans; Melatonin; Models, Biological; Reactive Oxygen S | 2001 |
1 trial available for melatonin and Gastric Ulcer
| Article | Year |
|---|---|
Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans.
Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Gastric | 2011 |
44 other studies available for melatonin and Gastric Ulcer
| Article | Year |
|---|---|
Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade.
Topics: Animals; Down-Regulation; Indomethacin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matr | 2022 |
Simultaneous detection of melatonin and six metabolites of L-tryptophan pathway in rat gastric mucosa.
Topics: Animals; Gastric Mucosa; Melatonin; Pineal Gland; Rats; Stomach Ulcer; Tryptophan | 2021 |
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity.
Topics: Animals; Gastric Mucosa; Ketorolac; Melatonin; Rats; Stomach; Stomach Ulcer; Ulcer | 2023 |
Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats.
Topics: Animals; Inflammation Mediators; Interleukin-1beta; Leukocytes; Male; Melatonin; Rats; Rats, Wistar; | 2013 |
[Melatonin as a therapeutic factor in gastric ulcer healing under experimental diabetes].
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Gastric Mucosa; Male; Melatonin; Pineal Glan | 2013 |
Ghrelin gene expression in rats with ethanol-induced gastric ulcers: a role of melatonin.
Topics: Animals; Ethanol; Gastric Mucosa; Gene Expression Regulation; Ghrelin; Glutathione; Male; Malondiald | 2015 |
[Participation of pineal gland in antistressor activity of adaptogenic drugs].
Topics: Adrenal Glands; Animals; Anti-Anxiety Agents; Electroshock; Ginkgo biloba; Glycogen; Immobilization; | 2015 |
Melatonin and its precursor L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans.
Topics: Acute Disease; Adult; Aspirin; Dose-Response Relationship, Drug; Free Radical Scavengers; Gastric Mu | 2008 |
Tryptophan free diet delays healing of chronic gastric ulcers in rat.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Chronic Disease; Cyclooxygenase 2; Diet; Gastric Muco | 2008 |
Melatonin protects against hydrogen peroxide-induced gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Dose-Response Relationship, Drug; Drug Administration Ro | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr | 2009 |
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri | 2009 |
Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans.
Topics: Adult; Aspirin; Dinoprostone; Gastric Mucosa; Gastrins; Gastrointestinal Hemorrhage; Humans; Male; M | 2010 |
Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2.
Topics: Analysis of Variance; Animals; Gastric Mucosa; Histocytochemistry; Indomethacin; Male; Matrix Metall | 2010 |
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
Topics: Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Drug Interactions; Gel | 2011 |
[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytoprotection; D | 2012 |
Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin.
Topics: Animals; Antioxidants; Blotting, Western; Chronic Disease; Extracellular Signal-Regulated MAP Kinase | 2012 |
Desynchronosis and erosive and ulcerative lesions of the stomach in rats active or passive in the open-field test: effect of exogenous melatonin.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Male; Melatonin; Motor Activity; Photoperiod; Rats; Rat | 2003 |
Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2004 |
Melatonin protects against piroxicam-induced gastric ulceration.
Topics: Actinin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Cyclooxygena | 2004 |
Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes.
Topics: Acetic Acid; Animals; Colitis; Darkness; Ethanol; Female; Gastric Mucosa; Inflammation; Intestinal M | 2005 |
Effect of melatonin on secreted and induced matrix metalloproteinase-9 and -2 activity during prevention of indomethacin-induced gastric ulcer.
Topics: Animals; Enzyme Induction; Indomethacin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase | 2005 |
Importance of the pineal gland, endogenous prostaglandins and sensory nerves in the gastroprotective actions of central and peripheral melatonin against stress-induced damage.
Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; C | 2005 |
Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
Topics: Animals; Antioxidants; Collagenases; Disease Models, Animal; DNA Primers; Enzyme Precursors; Gene Ex | 2006 |
Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice.
Topics: Animals; Enzyme Activation; Enzyme Induction; Ethanol; Matrix Metalloproteinase 2; Matrix Metallopro | 2007 |
Day/night differences in stress-induced gastric lesions in rats with an intact pineal gland or after pinealectomy.
Topics: Animals; Circadian Rhythm; Cyclooxygenase 2; Dinoprostone; Free Radicals; Gastrins; Male; Melatonin; | 2008 |
Role of circadian rhythm and endogenous melatonin in pathogenesis of acute gastric bleeding erosions induced by stress.
Topics: Acute Disease; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Me | 2007 |
Dynamic physiological and molecular changes in gastric ulcer healing achieved by melatonin and its precursor L-tryptophan in rats.
Topics: Acetates; Actins; Animals; Antioxidants; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Interleukin | 2008 |
Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects.
Topics: Animals; Antioxidants; Ethanol; Free Radicals; Gastric Mucosa; Luminescent Measurements; Male; Melat | 1997 |
Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischaemia-induced lesions is mediated by scavenge of oxygen radicals.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; DNA; Dose-Resp | 1997 |
Melatonin protects against gastric ischemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Biomarkers; Female; Gastric Mucosa; Glutathione Peroxidase; Injections, Intra | 1997 |
The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; DNA; Dose-Response Relatio | 1997 |
Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs.
Topics: Animal Feed; Animals; Diet; Female; Gastric Mucosa; Incidence; Intestinal Mucosa; Male; Melatonin; R | 1998 |
[Melatonin and gastric ulcer development during acute emotional stress in rats].
Topics: Acute Disease; Animals; Injections, Intraperitoneal; Male; Melatonin; Rats; Rats, Wistar; Stomach Ul | 1998 |
Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Free Radical Scavengers; Indomethacin; Male; Melatonin; Pineal G | 1998 |
Protective effect of melatonin on indomethacin-induced gastric injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Free Radical Scavengers; Gastric Mucosa; G | 1999 |
[Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats].
Topics: Animals; Antioxidants; Body Temperature; Circadian Rhythm; Disease Models, Animal; Injections, Intra | 2000 |
Roles of nocturnal melatonin and the pineal gland in modulation of water-immersion restraint stress-induced gastric mucosal lesions in rats.
Topics: Animals; Circadian Rhythm; Free Radical Scavengers; Gastric Mucosa; Male; Melatonin; Pineal Gland; R | 2001 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease | 2001 |
Circadian rhythm of melatonin and prostaglandin in modulation of stress-induced gastric mucosal lesions in rats.
Topics: Animals; Circadian Rhythm; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Isoenzy | 2002 |
Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan.
Topics: Actins; Animals; Capsaicin; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Male; Melaton | 2002 |
[Study of gastric APUD cells in gastroduodenal hemorrhage].
Topics: Adult; Aged; APUD Cells; Catecholamines; Cell Count; Duodenal Ulcer; Female; Gastrins; Hormones, Ect | 1990 |
The effect of melatonin on the formation of gastric stress lesions in rats.
Topics: Animals; Male; Melatonin; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Ph | 1990 |
Modulating action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomachs.
Topics: Animals; Ethanol; Gastric Mucosa; Male; Melatonin; Premedication; Rats; Rats, Inbred Strains; Region | 1989 |