melatonin has been researched along with Fragile X Syndrome in 6 studies
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy of melatonin on sleep problems in children with autistic spectrum disorder (ASD) and fragile X syndrome (FXS)." | 9.14 | The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. ( Anders, TF; Bacalman, S; Diaz, R; Goodlin-Jones, BL; Hagerman, RJ; Jacquemont, S; Wirojanan, J, 2009) |
| "Fragile X syndrome is the most common form of inherited mental retardation." | 5.35 | Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. ( de Diego-Otero, Y; de Fonseca, FR; Decara, J; Del Arco-Herrera, I; el Bekay, R; Romero-Zerbo, Y; Sanchez-Salido, L, 2009) |
| "To determine the efficacy of melatonin on sleep problems in children with autistic spectrum disorder (ASD) and fragile X syndrome (FXS)." | 5.14 | The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. ( Anders, TF; Bacalman, S; Diaz, R; Goodlin-Jones, BL; Hagerman, RJ; Jacquemont, S; Wirojanan, J, 2009) |
| "Fragile X syndrome is the most common form of inherited mental retardation." | 1.35 | Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. ( de Diego-Otero, Y; de Fonseca, FR; Decara, J; Del Arco-Herrera, I; el Bekay, R; Romero-Zerbo, Y; Sanchez-Salido, L, 2009) |
| "Melatonin profiles were studied in five males with cytogenetic and clinical features of the fragile-X syndrome including megalo-orchidia and macrogenitosomia." | 1.27 | Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome? ( Andrews, H; Arendt, J; Astley, P; Corrall, RJ; O'Brien, IA; O'Hare, JP; Ratcliffe, W; Walters, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Won, J | 1 |
| Jin, Y | 1 |
| Choi, J | 1 |
| Park, S | 1 |
| Lee, TH | 1 |
| Lee, SR | 1 |
| Chang, KT | 1 |
| Hong, Y | 1 |
| Romero-Zerbo, Y | 1 |
| Decara, J | 1 |
| el Bekay, R | 1 |
| Sanchez-Salido, L | 1 |
| Del Arco-Herrera, I | 1 |
| de Fonseca, FR | 1 |
| de Diego-Otero, Y | 1 |
| Wirojanan, J | 1 |
| Jacquemont, S | 1 |
| Diaz, R | 1 |
| Bacalman, S | 1 |
| Anders, TF | 1 |
| Hagerman, RJ | 2 |
| Goodlin-Jones, BL | 1 |
| Hagerman, R | 1 |
| Lauterborn, J | 1 |
| Au, J | 1 |
| Berry-Kravis, E | 1 |
| Gould, EL | 1 |
| Loesch, DZ | 1 |
| Martin, MJ | 1 |
| Armstrong, SM | 1 |
| Huggins, RM | 1 |
| O'Hare, JP | 1 |
| O'Brien, IA | 1 |
| Arendt, J | 1 |
| Astley, P | 1 |
| Ratcliffe, W | 1 |
| Andrews, H | 1 |
| Walters, R | 1 |
| Corrall, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Double-blind Randomized Placebo-controlled 1-way Crossover Trial to Investigate Safety and Efficacy of the Ascorbic Acid and Tocopherol for the Treatment of the Fragile X Syndrome[NCT01329770] | Phase 2 | 30 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Fragile X Syndrome
| Article | Year |
|---|---|
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation | 2017 |
Fragile X syndrome and targeted treatment trials.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Baclofen; Brain-Derived Neurotrophic Factor; Central N | 2012 |
1 trial available for melatonin and Fragile X Syndrome
| Article | Year |
|---|---|
The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome.
Topics: Adolescent; Autistic Disorder; Central Nervous System Depressants; Child; Child, Preschool; Cross-Ov | 2009 |
3 other studies available for melatonin and Fragile X Syndrome
| Article | Year |
|---|---|
Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome.
Topics: Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Fragile X Mental Retardation Protei | 2009 |
Melatonin profiles and sleep characteristics in boys with fragile X syndrome: a preliminary study.
Topics: Age Factors; Body Mass Index; Child; Child, Preschool; Fragile X Syndrome; Humans; Male; Melatonin; | 2000 |
Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome?
Topics: Aged; Fragile X Syndrome; Genitalia, Male; Humans; Male; Melatonin; Middle Aged; Pedigree; Penis; Se | 1986 |