melatonin has been researched along with Flaccid Quadriplegia in 11 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we examined the evening onset of melatonin secretion, an important hormone for the initiation of sleep, in people with a complete cervical (tetraplegia) and thoracic (paraplegia) SCI, and age- and sex-matched able-bodied control participants." | 3.78 | Complete absence of evening melatonin increase in tetraplegics. ( Atkinson, G; Groothuis, JT; Hopman, MT; Jones, H; Nyakayiru, J; Thijssen, DH; Thompson, A; Verheggen, RJ, 2012) |
| "However, in subjects with tetraplegia the melatonin levels are blunted." | 2.87 | Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation. ( Bertolucci, C; Dahm, A; Frigato, E; Iversen, PO; Kostovski, E; Mowinckel, MC; Sandset, PM; Savikj, M; Skretting, G; Østerud, B, 2018) |
| "Six men with long-standing complete tetraplegia were included in a randomised placebo-controlled cross-over study with melatonin supplementation (2 mg, 4 consecutive nights), whereas six healthy, able-bodied men served as controls." | 2.80 | Reduced peak, but no diurnal variation, in thrombin generation upon melatonin supplementation in tetraplegia. A randomised, placebo-controlled study. ( Dahm, A; Iversen, PO; Kostovski, E; Mowinckel, MC; Sandset, PM; Skretting, G; Stranda, A; Østerud, B, 2015) |
| "Eight individuals with tetraplegia, having an absence of endogenous melatonin production and the presence of a sleep disorder." | 2.79 | Randomized controlled trial of pharmacological replacement of melatonin for sleep disruption in individuals with tetraplegia. ( Kiratli, BJ; Ku, B; Ota, D; Zeitzer, JM, 2014) |
| "Recently, we reported that tetraplegia is associated with a blunted release of melatonin in the evening." | 1.40 | Within-subject correlations between evening-related changes in body temperature and melatonin in the spinal cord injured. ( Atkinson, G; Eijsvogels, TM; Groothuis, JT; Hopman, MT; Jones, H; Nyakayiru, J; Thijssen, DH; Thompson, A; Verheggen, RJ, 2014) |
| "Melatonin production was absent in the three tetraplegic subjects with injury to their lower cervical spinal cord and was of normal amplitude and timing in the two paraplegic subjects with injury to their upper thoracic spinal cord." | 1.31 | Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia. ( Ayas, NT; Brown, R; Czeisler, CA; Shea, SA; Zeitzer, JM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kostovski, E | 3 |
| Frigato, E | 1 |
| Savikj, M | 1 |
| Dahm, A | 3 |
| Sandset, PM | 4 |
| Mowinckel, MC | 3 |
| Skretting, G | 3 |
| Østerud, B | 3 |
| Bertolucci, C | 1 |
| Iversen, PO | 4 |
| Zeitzer, JM | 2 |
| Ku, B | 1 |
| Ota, D | 1 |
| Kiratli, BJ | 1 |
| Jones, H | 2 |
| Eijsvogels, TM | 1 |
| Nyakayiru, J | 2 |
| Verheggen, RJ | 2 |
| Thompson, A | 2 |
| Groothuis, JT | 2 |
| Atkinson, G | 2 |
| Hopman, MT | 2 |
| Thijssen, DH | 2 |
| Spong, J | 1 |
| Kennedy, GA | 1 |
| Tseng, J | 1 |
| Brown, DJ | 1 |
| Armstrong, S | 1 |
| Berlowitz, DJ | 1 |
| Dahm, AE | 1 |
| Stranda, A | 2 |
| Tanaka, H | 1 |
| Kakutani, S | 1 |
| Araki, A | 1 |
| Fukuda, I | 1 |
| Oka, R | 1 |
| Cho, K | 1 |
| Osterud, B | 1 |
| Hjeltnes, N | 1 |
| Ayas, NT | 1 |
| Shea, SA | 1 |
| Brown, R | 1 |
| Czeisler, CA | 1 |
| Kneisley, LW | 1 |
| Moskowitz, MA | 1 |
| Lynch, HG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Melatonin Replacement for Treatment of Sleep Disruption[NCT00507546] | Phase 4 | 12 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| The Role of Melatonin in the Regulation of Blood Coagulation[NCT01741389] | Phase 1 | 12 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measured as the median of the average WASO of the three weeks of either placebo or ramelteon treatment (NCT00507546)
Timeframe: 10 weeks
| Intervention | Minutes (Median) |
|---|---|
| Ramelteon | 72.3 |
| Placebo | 76.5 |
Measured as the median of the average morning alertness (measured from 1-7 on the Stanford Sleepiness Scale, a Likert-like scale in which higher values are lower alertness) of the three weeks of either placebo or ramelteon treatment (NCT00507546)
Timeframe: 10 weeks
| Intervention | units on a scale (Median) |
|---|---|
| Arm 1 | 2.86 |
| Arm 2 | 3.14 |
5 trials available for melatonin and Flaccid Quadriplegia
| Article | Year |
|---|---|
Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation.
Topics: Adult; Central Nervous System Agents; CLOCK Proteins; Cross-Over Studies; Double-Blind Method; Human | 2018 |
Randomized controlled trial of pharmacological replacement of melatonin for sleep disruption in individuals with tetraplegia.
Topics: Antioxidants; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Mela | 2014 |
Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin.
Topics: Adult; Affect; Aged; Antioxidants; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Me | 2014 |
Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin.
Topics: Adult; Central Nervous System Agents; Cervical Cord; Circadian Rhythm; Cross-Over Studies; Double-Bl | 2015 |
Reduced peak, but no diurnal variation, in thrombin generation upon melatonin supplementation in tetraplegia. A randomised, placebo-controlled study.
Topics: Adult; Blood Coagulation Tests; Cross-Over Studies; Double-Blind Method; Hemostasis; Humans; Male; M | 2015 |
6 other studies available for melatonin and Flaccid Quadriplegia
| Article | Year |
|---|---|
Within-subject correlations between evening-related changes in body temperature and melatonin in the spinal cord injured.
Topics: Adult; Body Temperature Regulation; Case-Control Studies; Circadian Rhythm; Cross-Sectional Studies; | 2014 |
Complete absence of evening melatonin increase in tetraplegics.
Topics: Adult; Case-Control Studies; Circadian Rhythm; Cross-Sectional Studies; Humans; Male; Melatonin; Mid | 2012 |
[Combined use of melatonin and low-dose flunitrazepam for treatment of sleep disturbance in a child with spastic quadriplegia: evaluation using polysomnography].
Topics: Adolescent; Anti-Anxiety Agents; Circadian Rhythm; Drug Therapy, Combination; Evaluation Studies as | 2002 |
Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: does daylight affect coagulation?
Topics: Blood Coagulation; Circadian Rhythm; Endothelium, Vascular; Hemostasis; Humans; Light; Lipoproteins; | 2006 |
Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia.
Topics: Adult; Cervical Vertebrae; Circadian Rhythm; Humans; Hydrocortisone; Male; Melatonin; Paraplegia; Qu | 2000 |
Cervical spinal cord lesions disrupt the rhythm in human melatonin excretion.
Topics: Adult; Aldosterone; Circadian Rhythm; Growth Hormone; Humans; Hydrocortisone; Male; Melatonin; Parap | 1978 |