melatonin has been researched along with Fever in 12 studies
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "In 24 h water deprived rats we have evaluated the effects of melatonin on the inhibition of thirst and on fever induced by Escherichia coli lipopolysaccharide." | 7.69 | Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat. ( Calapai, G; Caputi, AP; Cuzzocrea, S; De Sarro, A; Facciolà, G; Giuliani, G; Nava, F, 1997) |
| "Fever is considered an important host defense response but requires significant metabolic energy." | 5.31 | Melatonin regulates energy balance and attenuates fever in Siberian hamsters. ( Bilbo, SD; Nelson, RJ, 2002) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "In 24 h water deprived rats we have evaluated the effects of melatonin on the inhibition of thirst and on fever induced by Escherichia coli lipopolysaccharide." | 3.69 | Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat. ( Calapai, G; Caputi, AP; Cuzzocrea, S; De Sarro, A; Facciolà, G; Giuliani, G; Nava, F, 1997) |
| "Melatonin is a neurohormone that has anticonvulsant activity in different experimental seizure models including hyperthermic febrile seizure." | 1.51 | Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats. ( Aydin, L; Baltaci, AK; Mogulkoc, R, 2019) |
| "Fever is considered an important host defense response but requires significant metabolic energy." | 1.31 | Melatonin regulates energy balance and attenuates fever in Siberian hamsters. ( Bilbo, SD; Nelson, RJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mogulkoc, R | 1 |
| Baltaci, AK | 1 |
| Aydin, L | 1 |
| Schmelting, B | 1 |
| Corbach-Söhle, S | 1 |
| Kohlhause, S | 1 |
| Schlumbohm, C | 1 |
| Flügge, G | 1 |
| Fuchs, E | 1 |
| Fenn, AM | 1 |
| Fonken, LK | 1 |
| Nelson, RJ | 2 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chao, CM | 1 |
| Chang, CK | 1 |
| Lin, MT | 1 |
| Chang, CP | 1 |
| Bruno, VA | 1 |
| Scacchi, PA | 1 |
| Perez-Lloret, S | 1 |
| Esquifino, AI | 1 |
| Cardinali, DP | 1 |
| Cutrera, RA | 1 |
| Bonior, J | 1 |
| Jaworek, J | 1 |
| Konturek, SJ | 1 |
| Pawlik, WW | 1 |
| Nava, F | 1 |
| Calapai, G | 1 |
| Facciolà, G | 1 |
| Cuzzocrea, S | 1 |
| Giuliani, G | 1 |
| De Sarro, A | 1 |
| Caputi, AP | 1 |
| Rozenboim, I | 1 |
| Miara, L | 1 |
| Wolfenson, D | 1 |
| Raghavendra, V | 2 |
| Agrewala, JN | 1 |
| Kulkarni, SK | 2 |
| Ali, SF | 1 |
| Martin, JL | 1 |
| Black, MD | 1 |
| Itzhak, Y | 1 |
| Bilbo, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for melatonin and Fever
| Article | Year |
|---|---|
Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Fever; Male; Melatonin; Prazosi | 2019 |
Agomelatine in the tree shrew model of depression: effects on stress-induced nocturnal hyperthermia and hormonal status.
Topics: Acetamides; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Body Temperatu | 2014 |
Sustained melatonin treatment blocks body mass, pelage, reproductive, and fever responses to short day lengths in female Siberian hamsters.
Topics: Adaptation, Physiological; Animals; Antioxidants; Body Weight; Cricetinae; Female; Fever; Lipopolysa | 2011 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin treatment counteracts the hyperthermic effect of lipopolysaccharide injection in the Syrian hamster.
Topics: Administration, Oral; Animals; Body Temperature; Circadian Rhythm; Cricetinae; Drug Interactions; Fe | 2005 |
Increase of heat shock protein gene expression by melatonin in AR42J cells.
Topics: Actins; Animals; Cell Line; Ceruletide; Chaperonin 60; Fever; Free Radical Scavengers; Gene Expressi | 2005 |
Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat.
Topics: Animals; Bacterial Toxins; Body Temperature; Brain; Dinoprostone; Dose-Response Relationship, Drug; | 1997 |
The thermoregulatory mechanism of melatonin-induced hypothermia in chicken.
Topics: Animals; Body Temperature Regulation; Chickens; Cold Temperature; Female; Fever; Hot Temperature; Hy | 1998 |
Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase Inhibitors; Dinop | 1999 |
Neuroprotective role of melatonin in methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Dopamine Agents; D | 1999 |
Melatonin reversal of DOI-induced hypophagia in rats; possible mechanism by suppressing 5-HT(2A) receptor-mediated activation of HPA axis.
Topics: Adrenal Glands; Amphetamines; Animals; Anorexia; Ascorbic Acid; Exploratory Behavior; Feeding Behavi | 2000 |
Melatonin regulates energy balance and attenuates fever in Siberian hamsters.
Topics: Animals; Antioxidants; Body Temperature; Body Weight; Cricetinae; Darkness; Eating; Energy Metabolis | 2002 |