melatonin has been researched along with Fatigue in 63 studies
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia." | 9.24 | The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017) |
| " In this prospective phase II trial, we sought to assess the effect of melatonin on circadian biomarkers, sleep, and quality of life in breast cancer patients." | 9.22 | The effect of melatonin on sleep and quality of life in patients with advanced breast cancer. ( Bjarnason, GA; Clemons, M; Eisen, A; Innominato, PF; Kiss, A; Lim, AS; Palesh, O; Pritchard, KI; Trudeau, M; Wang, C, 2016) |
| " No significant differences between the placebo and melatonin periods were found for physical fatigue, secondary outcomes, or explorative outcomes." | 9.20 | Effects of melatonin on physical fatigue and other symptoms in patients with advanced cancer receiving palliative care: A double-blind placebo-controlled crossover trial. ( Andersen, L; Groenvold, M; Klee Olsen, M; Lindholm, H; Lund Rasmussen, C; Pedersen, L; Petersen, MA; Thit Johnsen, A; Villadsen, B, 2015) |
| "Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer." | 9.17 | Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013) |
| "The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM)." | 7.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 7.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| "To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality." | 7.80 | Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014) |
| "To assess the influence of IFN-β treatment on melatonin secretion, fatigue and sleep characteristics in patients with MS." | 7.78 | Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. ( Golan, D; Lavi, I; Luboshitzky, R; Melamud, L; Miller, A, 2012) |
| "To observe the acupoint compatibility effect of Shenmen (HT7) and Sanyinjiao (SP6) in improving daytime fatigue and sleepiness of insomnia, and its mechanism in regulating hypothalamic-pituitary-adrenal (HPA) axis and suprachiasmatic nucleus-pineal gland-melatonin (SCN-PG-MT) system." | 5.51 | [Acupoint compatibility effect and mechanism of Shenmen (HT7) and Sanyinjiao (SP6) in improving daytime fatigue and sleepiness of insomnia]. ( Du, L; Li, ZW; Song, XJ; Wu, P; Zhu, YH, 2022) |
| "Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks." | 5.39 | Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013) |
| " Common PPCS complaints such as sleep disturbance and fatigue could be ameliorated via the supplementation of melatonin, which has significant neuroprotective and anti-inflammatory properties." | 5.34 | Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial. ( Barlow, KM; Cocchi, L; Iyer, KK; Zalesky, A, 2020) |
| "The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia." | 5.24 | The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017) |
| " In this prospective phase II trial, we sought to assess the effect of melatonin on circadian biomarkers, sleep, and quality of life in breast cancer patients." | 5.22 | The effect of melatonin on sleep and quality of life in patients with advanced breast cancer. ( Bjarnason, GA; Clemons, M; Eisen, A; Innominato, PF; Kiss, A; Lim, AS; Palesh, O; Pritchard, KI; Trudeau, M; Wang, C, 2016) |
| " No significant differences between the placebo and melatonin periods were found for physical fatigue, secondary outcomes, or explorative outcomes." | 5.20 | Effects of melatonin on physical fatigue and other symptoms in patients with advanced cancer receiving palliative care: A double-blind placebo-controlled crossover trial. ( Andersen, L; Groenvold, M; Klee Olsen, M; Lindholm, H; Lund Rasmussen, C; Pedersen, L; Petersen, MA; Thit Johnsen, A; Villadsen, B, 2015) |
| "Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer." | 5.17 | Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013) |
| " Core and skin temperature, heart rate, salivary melatonin, ratings of perceived fatigue, and recovery were measured in each trial." | 5.17 | Effect of evening postexercise cold water immersion on subsequent sleep. ( Dawson, B; Eastwood, P; Goodman, C; Gregson, W; Halson, S; King, S; Robey, E, 2013) |
| "The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM)." | 3.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 3.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| "To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality." | 3.80 | Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014) |
| "To assess the influence of IFN-β treatment on melatonin secretion, fatigue and sleep characteristics in patients with MS." | 3.78 | Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. ( Golan, D; Lavi, I; Luboshitzky, R; Melamud, L; Miller, A, 2012) |
| "Melatonin, sleep disturbances, and symptoms (sleep, fatigue, mental) were compared among workers on permanent day, swing, and night shifts." | 3.73 | Melatonin, sleep, and shift work adaptation. ( Allen, E; Burch, JB; Johnson, W; Yost, MG, 2005) |
| "Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged-release melatonin (Circadin) or matched placebo, ingested orally once-daily before bedtime." | 2.94 | Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial. ( Coeytaux Jackson, A; Fang, BAM; Gilat, M; Grunstein, RR; Hall, JM; Hammond, D; Lewis, SJG; Marshall, NS; Mullins, AE; Wong, KKH; Yee, BJ, 2020) |
| "Different treatments, durations and cancer types were the main sources of heterogeneity." | 2.82 | Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. ( Bu, X; Chen, H; Fan, R; Li, X; Tan, Y; Wang, T; Yang, S, 2022) |
| "Fatigue was measured objectively with pre- and post-shift scores of the 3-minute psychomotor vigilance tasks (PVT-B) parameters (reaction times, number of lapses, errors and false starts) and subjectively with pre- and post-shift Karolinska Sleepiness Scale (KSS) ratings." | 1.48 | Investigating daily fatigue scores during two-week offshore day shifts. ( Brouwer, S; Bültmann, U; de Boer, M; Gordijn, M; Riethmeister, V, 2018) |
| "Stroke is a major cause of acquired cerebral disability among adults, frequently accompanied by depression, anxiety, cognitive impairment, disrupted sleep and fatigue." | 1.46 | Impact of naturalistic lighting on hospitalized stroke patients in a rehabilitation unit: Design and measurement. ( Iversen, HK; Jennum, P; Pavlova, M; Sander, B; Simonsen, SA; West, A, 2017) |
| "Melatonin plays an important role in protecting gastrointestinal tract from dysfunction, in which MTL, CGRP, CORT and CA are all involved." | 1.42 | [The experimental study on melatonin gastro intestinal motility and plasma levels of stress hormones in overtraining rat]. ( Jing, HF; Wang, XM, 2015) |
| "Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks." | 1.39 | Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013) |
| "Jet lag and travel fatigue have been identified by athletes, athletic trainers, coaches, and physicians as important but challenging problems that could benefit from practical solutions." | 1.38 | Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams. ( Samuels, CH, 2012) |
| "During the sleep deprivation, the mental task (Stroop color-word conflict test: CWT) was performed each 15 min in one hour." | 1.32 | Effect of bright light on EEG activities and subjective sleepiness to mental task during nocturnal sleep deprivation. ( Aoki, K; Iwanaga, K; Katsuura, T; Shimomura, Y; Shiomura, Y; Yokoi, M, 2003) |
| "Fatigue is often reported after long duration flights." | 1.32 | Hypoxic depression of melatonin secretion after simulated long duration flights in man. ( Batéjat, D; Beaumont, M; Charbuy, H; Coste, O; Touitou, Y; Van Beers, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (9.52) | 18.7374 |
| 1990's | 7 (11.11) | 18.2507 |
| 2000's | 16 (25.40) | 29.6817 |
| 2010's | 26 (41.27) | 24.3611 |
| 2020's | 8 (12.70) | 2.80 |
| Authors | Studies |
|---|---|
| de Bruijn, L | 1 |
| Starreveld, DEJ | 1 |
| Schaapveld, M | 1 |
| van Leeuwen, FE | 1 |
| Bleiker, EMA | 1 |
| Berentzen, NE | 1 |
| Song, XJ | 1 |
| Zhu, YH | 1 |
| Wu, P | 1 |
| Du, L | 1 |
| Li, ZW | 1 |
| Fan, R | 1 |
| Bu, X | 1 |
| Yang, S | 1 |
| Tan, Y | 1 |
| Wang, T | 1 |
| Chen, H | 1 |
| Li, X | 1 |
| Gilat, M | 1 |
| Coeytaux Jackson, A | 1 |
| Marshall, NS | 1 |
| Hammond, D | 1 |
| Mullins, AE | 1 |
| Hall, JM | 1 |
| Fang, BAM | 1 |
| Yee, BJ | 1 |
| Wong, KKH | 1 |
| Grunstein, RR | 1 |
| Lewis, SJG | 1 |
| Hemati, K | 1 |
| Amini Kadijani, A | 1 |
| Sayehmiri, F | 1 |
| Mehrzadi, S | 1 |
| Zabihiyeganeh, M | 1 |
| Hosseinzadeh, A | 1 |
| Mirzaei, A | 1 |
| Wallace, PJ | 1 |
| Haber, JJ | 1 |
| Iyer, KK | 1 |
| Zalesky, A | 1 |
| Cocchi, L | 1 |
| Barlow, KM | 1 |
| Sholtes, D | 1 |
| Kravitz, HM | 1 |
| Deka, A | 1 |
| Westrick, J | 1 |
| Fogg, LF | 1 |
| Gottlieb, M | 1 |
| Sulkava, S | 1 |
| Ollila, HM | 1 |
| Alasaari, J | 1 |
| Puttonen, S | 1 |
| Härmä, M | 1 |
| Viitasalo, K | 1 |
| Lahtinen, A | 1 |
| Lindström, J | 1 |
| Toivola, A | 1 |
| Sulkava, R | 1 |
| Kivimäki, M | 1 |
| Vahtera, J | 1 |
| Partonen, T | 1 |
| Silander, K | 1 |
| Porkka-Heiskanen, T | 1 |
| Paunio, T | 1 |
| West, A | 1 |
| Jennum, P | 2 |
| Simonsen, SA | 1 |
| Sander, B | 1 |
| Pavlova, M | 1 |
| Iversen, HK | 1 |
| Fan, Y | 1 |
| Yuan, L | 1 |
| Ji, M | 1 |
| Yang, J | 1 |
| Gao, D | 1 |
| Rahman, MM | 1 |
| Kwon, HS | 1 |
| Kim, MJ | 1 |
| Go, HK | 1 |
| Oak, MH | 1 |
| Kim, DH | 1 |
| Chang, WP | 1 |
| Lin, CC | 1 |
| Riethmeister, V | 1 |
| Bültmann, U | 1 |
| Gordijn, M | 1 |
| Brouwer, S | 1 |
| de Boer, M | 1 |
| Bin, YS | 1 |
| Postnova, S | 1 |
| Cistulli, PA | 1 |
| Ganesan, S | 1 |
| Magee, M | 1 |
| Stone, JE | 1 |
| Mulhall, MD | 1 |
| Collins, A | 1 |
| Howard, ME | 1 |
| Lockley, SW | 1 |
| Rajaratnam, SMW | 1 |
| Sletten, TL | 1 |
| Del Fabbro, E | 1 |
| Dev, R | 1 |
| Hui, D | 1 |
| Palmer, L | 1 |
| Bruera, E | 1 |
| Hansen, MV | 2 |
| Madsen, MT | 2 |
| Wildschiødtz, G | 1 |
| Rosenberg, J | 3 |
| Gögenur, I | 3 |
| Wilhelmsen-Langeland, A | 1 |
| Saxvig, IW | 1 |
| Pallesen, S | 1 |
| Nordhus, IH | 1 |
| Vedaa, Ø | 1 |
| Lundervold, AJ | 1 |
| Bjorvatn, B | 1 |
| Barun, B | 1 |
| Pardini, M | 1 |
| Cordano, C | 1 |
| Benassi, F | 1 |
| Mattei, C | 1 |
| Sassos, D | 1 |
| Guida, S | 1 |
| Serrati, C | 1 |
| Primavera, A | 1 |
| Amore, M | 1 |
| Cocito, L | 1 |
| Emberti Gialloreti, L | 1 |
| Pickering, L | 1 |
| Gammeltoft, S | 1 |
| Poulsgaard, L | 1 |
| Feldt-Rasmussen, U | 1 |
| Klose, M | 1 |
| Andersen, LT | 1 |
| Hageman, I | 1 |
| Rasmussen, LS | 1 |
| Bokmand, S | 1 |
| Joustra, SD | 1 |
| Thijs, RD | 1 |
| van den Berg, R | 1 |
| van Dijk, M | 1 |
| Pereira, AM | 1 |
| Lammers, GJ | 1 |
| van Someren, EJ | 1 |
| Romijn, JA | 1 |
| Biermasz, NR | 1 |
| Boivin, DB | 1 |
| Boudreau, P | 1 |
| Russcher, M | 1 |
| Chaves, I | 1 |
| Lech, K | 1 |
| Koch, BC | 1 |
| Nagtegaal, JE | 1 |
| Dorsman, KF | 1 |
| Jong, A' | 1 |
| Kayser, M | 1 |
| van Faassen, HM | 1 |
| Kema, IP | 1 |
| van der Horst, GT | 1 |
| Gaillard, CA | 1 |
| Lund Rasmussen, C | 1 |
| Klee Olsen, M | 1 |
| Thit Johnsen, A | 1 |
| Petersen, MA | 1 |
| Lindholm, H | 1 |
| Andersen, L | 1 |
| Villadsen, B | 1 |
| Groenvold, M | 1 |
| Pedersen, L | 1 |
| Innominato, PF | 1 |
| Lim, AS | 1 |
| Palesh, O | 1 |
| Clemons, M | 1 |
| Trudeau, M | 1 |
| Eisen, A | 1 |
| Wang, C | 1 |
| Kiss, A | 1 |
| Pritchard, KI | 1 |
| Bjarnason, GA | 1 |
| Jing, HF | 1 |
| Wang, XM | 1 |
| Reilly, T | 3 |
| Waterhouse, J | 3 |
| Edwards, B | 1 |
| Kücükakin, B | 1 |
| Bisgaard, T | 1 |
| Kristiansen, V | 1 |
| Hjortsø, NC | 1 |
| Skene, DJ | 1 |
| Chennaoui, M | 1 |
| Desgorces, F | 1 |
| Drogou, C | 1 |
| Boudjemaa, B | 1 |
| Tomaszewski, A | 1 |
| Depiesse, F | 1 |
| Burnat, P | 1 |
| Chalabi, H | 1 |
| Gomez-Merino, D | 1 |
| Carter, KA | 1 |
| Lettieri, CJ | 1 |
| Peńa, JM | 1 |
| Minami, M | 1 |
| Takahashi, H | 1 |
| Sasaki, T | 1 |
| Matsumoto, S | 1 |
| Sakai, K | 1 |
| Inagaki, H | 1 |
| Yamano, Y | 1 |
| Miyake, H | 1 |
| Melamud, L | 1 |
| Golan, D | 1 |
| Luboshitzky, R | 1 |
| Lavi, I | 1 |
| Miller, A | 1 |
| Samuels, CH | 1 |
| Robey, E | 1 |
| Dawson, B | 1 |
| Halson, S | 1 |
| Gregson, W | 1 |
| King, S | 1 |
| Goodman, C | 1 |
| Eastwood, P | 1 |
| Yokoi, M | 1 |
| Aoki, K | 1 |
| Shimomura, Y | 1 |
| Iwanaga, K | 1 |
| Katsuura, T | 1 |
| Shiomura, Y | 1 |
| Paul, MA | 2 |
| Gray, G | 2 |
| Kenny, G | 1 |
| Pigeau, RA | 1 |
| Petrie, KJ | 1 |
| Powell, D | 1 |
| Broadbent, E | 1 |
| Coste, O | 1 |
| Beaumont, M | 1 |
| Batéjat, D | 1 |
| Van Beers, P | 1 |
| Charbuy, H | 1 |
| Touitou, Y | 1 |
| Goel, N | 1 |
| Rüger, M | 1 |
| Gordijn, MC | 1 |
| Beersma, DG | 1 |
| de Vries, B | 1 |
| Daan, S | 1 |
| Burch, JB | 1 |
| Yost, MG | 1 |
| Johnson, W | 1 |
| Allen, E | 1 |
| Gorfine, T | 1 |
| Assaf, Y | 1 |
| Goshen-Gottstein, Y | 1 |
| Yeshurun, Y | 1 |
| Zisapel, N | 1 |
| Payne, JK | 1 |
| Schuh, A | 1 |
| Miller, JC | 1 |
| Buick, F | 1 |
| Blazeski, S | 1 |
| Arendt, J | 3 |
| Borbely, AA | 1 |
| Franey, C | 1 |
| Wright, J | 1 |
| Akerstedt, T | 2 |
| Gillberg, M | 1 |
| Wetterberg, L | 2 |
| French, J | 1 |
| Bisson, RU | 1 |
| Neville, KJ | 1 |
| Mitcha, J | 1 |
| Storm, WF | 1 |
| Hakola, T | 1 |
| Härmä, MI | 1 |
| Laitinen, JT | 1 |
| Atkinson, G | 2 |
| Rosekind, MR | 1 |
| Gander, PH | 1 |
| Gregory, KB | 1 |
| Smith, RM | 1 |
| Miller, DL | 1 |
| Oyung, R | 1 |
| Webbon, LL | 1 |
| Johnson, JM | 1 |
| Sparaco, P | 1 |
| Durlach, J | 1 |
| Pagès, N | 1 |
| Bac, P | 1 |
| Bara, M | 1 |
| Guiet-Bara, A | 1 |
| Fröberg, JE | 1 |
| Friberg, Y | 1 |
| Critchley, PH | 1 |
| Malcolm, GP | 1 |
| Malcolm, PN | 1 |
| Gibb, WR | 1 |
| Parkes, JD | 1 |
| Petrie, K | 1 |
| Conaglen, JV | 1 |
| Thompson, L | 1 |
| Chamberlain, K | 1 |
| Nickelsen, T | 1 |
| Demisch, L | 1 |
| Demisch, K | 1 |
| Radermacher, B | 1 |
| Schöffling, K | 1 |
| Lieberman, HR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN[NCT01874847] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2013-09-30 | Active, not recruiting | ||
| The Sunlight Improves Depression in Stroke Patients[NCT04036565] | 46 participants (Actual) | Observational [Patient Registry] | 2017-10-09 | Completed | |||
| Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950] | 104 participants (Anticipated) | Interventional | 2017-06-26 | Recruiting | |||
| A Randomised Double-blind Placebo-controlled Trial on Encapsulated Lemon Balm Efficacy and Tolerance on Sleep Quality Changes, and Mood and Wellbeing Effects Using Objective and Subjective Measures[NCT05422599] | 99 participants (Actual) | Interventional | 2022-05-05 | Completed | |||
| Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609] | 60 participants (Anticipated) | Interventional | 2023-12-08 | Recruiting | |||
| The Traditional Chinese Medicine Department of Xin Qiao Hospital[NCT02619266] | Phase 2/Phase 3 | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| A Randomized Clinical Trial of Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients[NCT00513357] | Phase 3 | 82 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment[NCT00834886] | Phase 4 | 40 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer[NCT00925899] | Phase 2/Phase 3 | 72 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Difference in ESAS (Edmonton Symptom Assessment Scale) assessment scores of appetite (symptom) from baseline evaluation [± 3 days] to 4 week evaluation [± 3 days], where the severity at the time of assessment is rated from 0 to 10 on a numerical scale; with 0 meaning that the symptom is absent and 10 that it is the worst possible severity. (NCT00513357)
Timeframe: Baseline and at 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin | -0.83 |
| Placebo | -1.19 |
"Sleep diary, rise time (when participants rise from bed in the morning, self-report) before and after a randomized controlled 4 armed treatment study including a follow-up 3 months later.~Midnight is 0000; in the outcome measure table the value is given in minutes after midnight.~i.e. 530 equals 08:50 in the morning." (NCT00834886)
Timeframe: 1 day after two-week treatment ends
| Intervention | Minutes (Mean) |
|---|---|
| Combination | 530 |
| Melatonin | 506 |
| Bright Light | 520 |
| Placebo | 543 |
Actigraphy, sleep onset latency (SOL). An actigraph is a wrist-worn movement sensor that objectively record motor activity. Participants used an event button to mark bed time and rise time. The actiwatch is waterproof and participants were instructed not to take it off at any time during the data collection peroid. (NCT00834886)
Timeframe: 1 day after 2-week treatment ended
| Intervention | Minutes (Mean) |
|---|---|
| Combination | 11 |
| Melatonin | 21 |
| Bright Light | 15 |
| Placebo | 24 |
"Subjective sleepiness; Karolinska sleepiness scale (KSS). The KSS is a scale in which the subjects rate their concurrent sleepiness level. The scale is verbally anchored with steps ranging from 1 (very alert) to 9 (very sleepy, fighting sleep, effort to stay awake)." (NCT00834886)
Timeframe: 1 day after 2-week treatment ended
| Intervention | units on a scale (Mean) |
|---|---|
| Combination | 6.0 |
| Melatonin | 5.9 |
| Bright Light | 6.3 |
| Placebo | 6.5 |
"Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~Appetite loss was converted to a 0 til 100 scale according to the scoring manual for EORTC QLQ C15-PAL where 100 indicated maximum appetite loss (worst possible).~Note outcome reported for complete compliers" (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -0.8 |
| Placebo Then Melatonin | -3.2 |
"Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~Emotional function was converted to a 0 til 100 scale according to the scoring manual for EORTC QLQ C15-PAL where 100 indicated the best possible emotional function.~Note outcome reported for complete compliers" (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -0.6 |
| Placebo Then Melatonin | 3.3 |
"Primary outcome: Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~The physical fatigue scale conists of four item each ranging from one to five. The four item were summed and the scae was converted to 0 to 100, where 100 indicated maximum fatigue." (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -1.1 |
| Placebo Then Melatonin | -3.9 |
"Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~The general fatigue scale that consits of four items was converted to a 0 til 100 scale where 100 indicated maximum (worst possible) fatigue.~Note outcome reported for complete compliers" (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -3.2 |
| Placebo Then Melatonin | -2.1 |
"Primary outcome: Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~Insomnia was converted to a 0 til 100 scale according to the scoring manual for EORTC QLQ C15-PAL where 100 indicated maximum insomnia." (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -9.9 |
| Placebo Then Melatonin | -4.6 |
"Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~Pain was converted to a 0 til 100 scale according to the scoring manual for EORTC QLQ C15-PAL where 100 indicated maximum pain.~Note outcome reported for complete compliers" (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | 0.8 |
| Placebo Then Melatonin | 1.9 |
"Change from baseline to week one in intervention group minus change from baseline to week one in control group.~Because it was a cross-over trial this was calculated the following way:~Outcomes for arm 1 (melatonin then placebo) were calculated as the difference in mean change scores between week 1 and week 2 (scores for day 7 to day 1-scores for day 17 to day 10). Outcomes for arm 2 (placebo then melatonin) were calculated as the difference in mean change scores between week 2 and week 1 (scores for day 17 to day 10-scores for day 7 to day 1).~Quality of Life was converted to a 0 til 100 scale according to the scoring manual for EORTC QLQ C15-PAL where 100 indicated best possible quality of life.~Note outcome reported for complete compliers" (NCT00925899)
Timeframe: One week
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin Then Placebo | -0.8 |
| Placebo Then Melatonin | -3.2 |
11 reviews available for melatonin and Fatigue
| Article | Year |
|---|---|
Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials.
Topics: Adult; Fatigue; Humans; Melatonin; Neoplasms; Pain; Quality of Life; Randomized Controlled Trials as | 2022 |
Melatonin in the treatment of fibromyalgia symptoms: A systematic review.
Topics: Fatigue; Fibromyalgia; Humans; Melatonin; Pain; Randomized Controlled Trials as Topic | 2020 |
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees.
Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue | 2021 |
What works for jetlag? A systematic review of non-pharmacological interventions.
Topics: Circadian Rhythm; Fatigue; Humans; Jet Lag Syndrome; Melatonin; Photoperiod; Sleep; Travel | 2019 |
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis.
Topics: Animals; Fatigue; Humans; Melatonin; Multiple Sclerosis; Narcolepsy; Restless Legs Syndrome; Sleep W | 2013 |
Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review.
Topics: Adult; Aged; Blood Pressure; Body Temperature; Circadian Rhythm; Craniopharyngioma; Fatigue; Female; | 2014 |
Impacts of shift work on sleep and circadian rhythms.
Topics: Accidents; Arousal; Automobile Driving; Cardiovascular Diseases; Circadian Rhythm; Circadian Rhythm | 2014 |
Some chronobiological and physiological problems associated with long-distance journeys.
Topics: Aircraft; Biological Clocks; Body Temperature; Central Nervous System Depressants; Eating; Environme | 2009 |
The trajectory of biomarkers in symptom management for older adults with cancer.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aging; Anxiety; Biomarkers; Biomarkers, Tumor; Cy | 2006 |
Melatonin and jet lag.
Topics: Circadian Rhythm; Fatigue; Humans; Melatonin; Sports; Travel; United Kingdom | 1998 |
Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion.
Topics: Biological Clocks; Fatigue; Fibromyalgia; Humans; Light; Magnesium; Magnesium Deficiency; Melatonin; | 2002 |
17 trials available for melatonin and Fatigue
| Article | Year |
|---|---|
[Acupoint compatibility effect and mechanism of Shenmen (HT7) and Sanyinjiao (SP6) in improving daytime fatigue and sleepiness of insomnia].
Topics: Acupuncture Points; Adrenocorticotropic Hormone; Fatigue; Humans; Melatonin; Sleep Initiation and Ma | 2022 |
Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.
Topics: Aged; Clonazepam; Double-Blind Method; Eye Movements; Fatigue; Female; Humans; Male; Melatonin; Midd | 2020 |
Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial.
Topics: Adolescent; Brain; Central Nervous System Depressants; Child; Double-Blind Method; Fatigue; Female; | 2020 |
The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; China; Circadian Rhythm | 2017 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function.
Topics: Adolescent; Adult; Circadian Rhythm; Cognition; Double-Blind Method; Fatigue; Female; Humans; Male; | 2013 |
Agomelatine but not melatonin improves fatigue perception: a longitudinal proof-of-concept study.
Topics: Acetamides; Adult; Antidepressive Agents; Fatigue; Fatigue Syndrome, Chronic; Female; Follow-Up Stud | 2014 |
Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antidepressive Agents; Anxiety; Breast Neoplasms; Central Nervous System Depressants; D | 2014 |
Effects of melatonin on physical fatigue and other symptoms in patients with advanced cancer receiving palliative care: A double-blind placebo-controlled crossover trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Drug | 2015 |
The effect of melatonin on sleep and quality of life in patients with advanced breast cancer.
Topics: Actigraphy; Adult; Aged; Breast Neoplasms; Central Nervous System Depressants; Fatigue; Female; Huma | 2016 |
The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Double-B | 2009 |
Effect of evening postexercise cold water immersion on subsequent sleep.
Topics: Adult; Baths; Bicycling; Biomarkers; Body Temperature; Cold Temperature; Fatigue; Heart Rate; Humans | 2013 |
Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance.
Topics: Acetamides; Administration, Oral; Adult; Anti-Anxiety Agents; Antioxidants; Azabicyclo Compounds; Cr | 2003 |
Sleep-anticipating effects of melatonin in the human brain.
Topics: Adult; Arousal; Auditory Perception; Brain; Brain Mapping; Dominance, Cerebral; Double-Blind Method; | 2006 |
Circadian phase delay induced by phototherapeutic devices.
Topics: Adolescent; Adult; Aerospace Medicine; Analysis of Variance; Chronobiology Disorders; Fatigue; Femal | 2007 |
Effect of melatonin on jet lag after long haul flights.
Topics: Adult; Aged; Circadian Rhythm; Clinical Trials as Topic; Double-Blind Method; Fatigue; Female; Human | 1989 |
Influence of subchronic intake of melatonin at various times of the day on fatigue and hormonal levels: a placebo-controlled, double-blind trial.
Topics: Administration, Oral; Adult; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Hum | 1989 |
35 other studies available for melatonin and Fatigue
| Article | Year |
|---|---|
Single-item chronotype is associated with dim light melatonin onset in lymphoma survivors with fatigue.
Topics: Adult; Circadian Rhythm; Fatigue; Humans; Light; Lymphoma; Melatonin; Middle Aged; Randomized Contro | 2022 |
Top 10 evidence-based countermeasures for night shift workers.
Topics: Caffeine; Circadian Rhythm; Eating; Efficiency; Emergency Service, Hospital; Fatigue; Female; Humans | 2020 |
Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers.
Topics: Adult; Alleles; Brain; Circadian Rhythm; Computer Simulation; DNA Methylation; Fatigue; Female; Finl | 2017 |
Impact of naturalistic lighting on hospitalized stroke patients in a rehabilitation unit: Design and measurement.
Topics: Adult; Aged; Circadian Rhythm; Cognition; Fatigue; Female; Humans; Light; Male; Melatonin; Middle Ag | 2017 |
Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fatigue; Hypertension; I | 2017 |
Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; Depression; Fatigue; Female; | 2017 |
Investigating daily fatigue scores during two-week offshore day shifts.
Topics: Adult; Circadian Rhythm; Fatigue; Female; Humans; Hydrocortisone; Longitudinal Studies; Male; Melato | 2018 |
The Impact of Shift Work on Sleep, Alertness and Performance in Healthcare Workers.
Topics: Adult; Attention; Circadian Rhythm; Fatigue; Female; Health Personnel; Humans; Male; Melatonin; Midd | 2019 |
Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy.
Topics: Adult; Aged; Anesthesia, General; Breast Neoplasms; Fatigue; Female; Humans; Mastectomy, Segmental; | 2013 |
Sleep-wake and melatonin pattern in craniopharyngioma patients.
Topics: Adolescent; Adult; Aged; Circadian Rhythm; Craniopharyngioma; Cross-Sectional Studies; Disorders of | 2014 |
An observational study on disturbed peripheral circadian rhythms in hemodialysis patients.
Topics: Aged; Biomarkers; Cell Line; Circadian Rhythm; Fatigue; Female; Gene Expression Profiling; Humans; H | 2015 |
[The experimental study on melatonin gastro intestinal motility and plasma levels of stress hormones in overtraining rat].
Topics: Animals; Calcitonin Gene-Related Peptide; Catecholamines; Fatigue; Gastrointestinal Motility; Hydroc | 2015 |
Effects of Ramadan fasting on physical performance and metabolic, hormonal, and inflammatory parameters in middle-distance runners.
Topics: Adult; Affect; Athletic Performance; Energy Metabolism; Epinephrine; Fasting; Fatigue; Hormones; Hum | 2009 |
An unusual cause of insomnia following IED-induced traumatic brain injury.
Topics: Adult; Bombs; Brain Injuries; Central Nervous System Depressants; Depressive Disorder; Eye Injuries; | 2010 |
The effect of sleep restriction and psychological load on the diurnal metabolic changes in tryptamine-related compounds in human urine.
Topics: Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Circadian Rhythm; Fatigue; Fluoro | 2012 |
Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis.
Topics: Adult; Circadian Rhythm; Enzyme-Linked Immunosorbent Assay; Fatigue; Female; Humans; Interferon beta | 2012 |
Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams.
Topics: Athletes; Athletic Performance; Caffeine; Circadian Rhythm; Fatigue; Humans; Hypnotics and Sedatives | 2012 |
Effect of bright light on EEG activities and subjective sleepiness to mental task during nocturnal sleep deprivation.
Topics: Adult; Analysis of Variance; Body Temperature; Electroencephalography; Fatigue; Humans; Intelligence | 2003 |
[Spring fatigue--what helps?].
Topics: Complementary Therapies; Fatigue; Homeopathy; Humans; Melatonin; Phytotherapy; Seasons | 2004 |
Fatigue self-management strategies and reported fatigue in international pilots.
Topics: Adult; Aviation; Cross-Sectional Studies; Fatigue; Health Surveys; Humans; Hypnotics and Sedatives; | 2004 |
Hypoxic depression of melatonin secretion after simulated long duration flights in man.
Topics: Adult; Altitude; Atmospheric Pressure; Circadian Rhythm; Fatigue; Female; Humans; Hypoxia; Male; Mel | 2004 |
Late-night presentation of an auditory stimulus phase delays human circadian rhythms.
Topics: Acoustic Stimulation; Adult; Aged; Biological Clocks; Body Temperature; Circadian Rhythm; Fatigue; F | 2005 |
Weak relationships between suppression of melatonin and suppression of sleepiness/fatigue in response to light exposure.
Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Fatigue; Female; Humans; Light; Male; Me | 2005 |
Melatonin, sleep, and shift work adaptation.
Topics: Accidents, Occupational; Adaptation, Physiological; Adult; Circadian Rhythm; Fatigue; Female; Humans | 2005 |
[What helps to control vernal fatigue? (interview by Friederike Klein)].
Topics: Acclimatization; Adaptation, Physiological; Fatigue; Hibernation; Humans; Melatonin; Phototherapy; S | 2006 |
The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: a preliminary study.
Topics: Adult; Affect; Arousal; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Fat | 1984 |
The circadian covariation of fatigue and urinary melatonin.
Topics: Adult; Arousal; Attention; Circadian Rhythm; Fatigue; Humans; Melatonin; Motion Perception; Sleep De | 1982 |
Crew fatigue during simulated, long duration B-1B bomber missions.
Topics: Aerospace Medicine; Body Temperature; Circadian Rhythm; Computer Simulation; Fatigue; Humans; Hydroc | 1994 |
Circadian adjustment of men and women to night work.
Topics: Adaptation, Physiological; Adult; Age Distribution; Analysis of Variance; Body Temperature; Body Wei | 1996 |
Travel fatigue and jet-lag.
Topics: Aircraft; Circadian Rhythm; Diet; Exercise; Fatigue; Humans; Hypnotics and Sedatives; Light; Melaton | 1997 |
Managing fatigue in operational settings 1: Physiological considerations and counter-measures.
Topics: Aviation; Circadian Rhythm; Diet; Exercise; Fatigue; Humans; Melatonin; Occupational Health; Personn | 1997 |
Combating fatigue to enhance safety.
Topics: Accidents, Aviation; Aerospace Medicine; Caffeine; Circadian Rhythm; Ergonomics; Fatigue; Humans; Me | 1996 |
Melatonin excretion, body temperature and subjective arousal during 64 hours of sleep deprivation.
Topics: Adult; Arousal; Body Temperature; Fatigue; Humans; Male; Melatonin; Sleep Deprivation | 1979 |
Fatigue and melatonin in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Fatigue; Female; Humans; Male; Melatonin; Middle Aged; Parkinson Dis | 1991 |
Behavior, sleep and melatonin.
Topics: Animals; Behavior; Circadian Rhythm; Fatigue; Humans; Melatonin; Pineal Gland; Sleep; Wakefulness | 1986 |