melatonin has been researched along with Experimental Mammary Neoplasms in 83 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular and metabolic signaling mechanisms involved in human breast cancer growth and the associated consequences of circadian disruption by exposure to light-at-night (LAN)." | 8.87 | Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer. ( Blask, DE; Dauchy, EM; Dauchy, RT; Duplesis, T; Frasch, T; Hill, SM; Mao, L; Xiang, S; Yuan, L, 2011) |
| "Recent studies have suggested that the pineal hormone melatonin may protect against breast cancer, and the mechanisms underlying its actions are becoming clearer." | 8.85 | Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. ( Grant, SG; Latimer, JJ; Melan, MA; Witt-Enderby, PA, 2009) |
| "The aim of this study was to evaluate the role of melatonin and the tumor suppressor miR- 148a-3p on angiogenesis of breast cancer." | 7.91 | Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer. ( Aristizábal-Pachón, AF; Bajgelman, MC; Borin, TF; Ferreira, LC; Lacerda, JZ; Lopes, BC; Zuccari, DAPC, 2019) |
| "Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth and an increase when relapse occurred." | 7.70 | Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion. ( Bartsch, C; Bartsch, H; Besenthal, I; Buchberger, A; Effenberger-Klein, A; Kruse-Jarres, JD; Mecke, D; Rokos, H; Stieglitz, A, 1999) |
| "The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 5.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
| "Polycystic kidney disease is common in this transgenic line." | 5.32 | The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice. ( Alimova, IN; Anisimov, VN; Baturin, DA; Manton, KG; Popovich, IG; Semenchenko, AV; Yashin, AI; Zabezhinski, MA, 2003) |
| "The pineal hormone melatonin (MLT) has potent anti-breast cancer activity, its actions are heavily mediated via the MT1 receptor and subsequent modulation of downstream signaling pathways including cAMP/PKA, Erk/MAPK, p38, and Ca2+/calmodulin." | 4.89 | Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth. ( Blask, DE; Cheng, C; Dauchy, B; Hill, SM; Jockers, R; Mao, L; Yuan, L, 2013) |
| "This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular and metabolic signaling mechanisms involved in human breast cancer growth and the associated consequences of circadian disruption by exposure to light-at-night (LAN)." | 4.87 | Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer. ( Blask, DE; Dauchy, EM; Dauchy, RT; Duplesis, T; Frasch, T; Hill, SM; Mao, L; Xiang, S; Yuan, L, 2011) |
| "Recent studies have suggested that the pineal hormone melatonin may protect against breast cancer, and the mechanisms underlying its actions are becoming clearer." | 4.85 | Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. ( Grant, SG; Latimer, JJ; Melan, MA; Witt-Enderby, PA, 2009) |
| "The aim of this study was to evaluate the role of melatonin and the tumor suppressor miR- 148a-3p on angiogenesis of breast cancer." | 3.91 | Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer. ( Aristizábal-Pachón, AF; Bajgelman, MC; Borin, TF; Ferreira, LC; Lacerda, JZ; Lopes, BC; Zuccari, DAPC, 2019) |
| "The breast cancer xenografts nude mice treated with melatonin showed reduced tumor size (P=0." | 3.88 | Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells. ( Braga, CZ; Colombo, J; Ferreira, JPS; Girol, AP; Jardim-Perassi, BV; Júnior, RP; Moschetta, MG; Sonehara, NM; Zuccari, DAPC, 2018) |
| "In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments." | 3.73 | Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats. ( Alonso-González, C; Cos, S; González, A; Martínez-Campa, C; Mediavilla, D; Sánchez-Barceló, EJ, 2006) |
| "Our laboratory has demonstrated that treatment of MCF-7 breast cancer cells with melatonin (Mlt) followed 24h later with physiological concentrations of all-trans retinoic acid (atRA) results in apoptosis." | 3.71 | Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin. ( Anderson, MB; Bischoff, ED; Cheng, Q; Dai, J; Dwived, PD; Hill, SM; Kiefer, TL; Lai, L; Melancon, K; Moro, K; Nowfar, S; Teplitzky, SR; Yuan, L, 2002) |
| "Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth and an increase when relapse occurred." | 3.70 | Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion. ( Bartsch, C; Bartsch, H; Besenthal, I; Buchberger, A; Effenberger-Klein, A; Kruse-Jarres, JD; Mecke, D; Rokos, H; Stieglitz, A, 1999) |
| "The effects of the pineal hormone, melatonin, and of pinealectomy on the incidence of mammary adenocarcinoma in Sprague-Dawley rats treated with 7,12-dimethylbenz(alpha)-anthracene (DMBA) were investigated." | 3.66 | Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat. ( Chabner, B; Cohen, M; Lippman, M; Reichert, C; Roselle, D; Tamarkin, L, 1981) |
| "The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 1.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
| "Furthermore, changes in lung and liver metastasis and primary tumor growth and angiogenesis were evaluated." | 1.62 | Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer. ( Aytac, G; Dilmac, S; Karadas, AK; Tanriover, G, 2021) |
| "Melatonin caused an increase in total antioxidant status and a substantial reduction in ROS as estimated from aldehyde and ketone derivatives, lipid peroxidation at the initial (diene conjugates) and terminal stages (TBARS), and increased catalase and glutathione peroxidase activities." | 1.48 | Melatonin and Metformin Diminish Oxidative Stress in Heart Tissue in a Rat Model of High Fat Diet and Mammary Carcinogenesis. ( Bojkova, B; Demkow, U; Kurhaluk, N; Kyriienko, S; Radkowski, M; Winklewski, PJ; Zaitseva, OV, 2018) |
| "ER+ breast cancer rat model was established and then rats were randomly divided into five different groups as follows: control group, Diss group, adriamycin (ADM) group, MLT group, and MLT combined with adriamycin (M+A) group." | 1.42 | Protective and sensitive effects of melatonin combined with adriamycin on ER+ (estrogen receptor) breast cancer. ( Li, LX; Ma, C; Ma, T; Ma, ZQ; Xiang, C; Zhang, Y; Zhang, ZP, 2015) |
| "Pravastatin was given orally (1 00 mg/kg) and melatonin was added to the water (20 μg/ml)." | 1.40 | Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model. ( Adamicová, K; Adamkov, M; Bojková, B; Chmelová, M; Kajo, K; Kapinová, A; Kassayová, M; Kružliak, P; Kubatka, P; Orendáš, P; Péč, M; Sadloňová, V; Stollárová, N; Výbohová, D, 2014) |
| "Indomethacin was administered 3 times a week and melatonin 4 times a week, both substances in a concentration of 20 µg/ml of drinking water." | 1.38 | [Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats]. ( Ahlers, I; Ahlersová, E; Bojková, B; Kalická, K; Kubatka, P; Péč, M, 2012) |
| "Celecoxib was administered daily at a concentration of 1." | 1.35 | Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. ( Ahlers, I; Ahlersova, E; Bojkova, B; Kajo, K; Kassayova, M; Kubatka, P; Orendas, P; Pec, M, 2009) |
| "Melatonin (MEL) was administered in drinking water in a concentration of 4 microg/ml (daily from 3 p." | 1.34 | Effect of prolonged psychoemotional stress and melatonin on experimental mammary carcinogenesis in female rats. ( Ahlers, I; Ahlersová, E; Bobrov, N; Bojková, B; Friedmanová, L; Kassayová, M; Kubatka, P; Orendás, P, 2007) |
| "Melatonin has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic actions." | 1.33 | Effect of the preventive-therapeutic administration of melatonin on mammary tumour-bearing animals. ( Barriga, C; Garcia, JJ; Ortega, E; Rodríguez, AB; Saez, MC, 2005) |
| "Polycystic kidney disease is common in this transgenic line." | 1.32 | The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice. ( Alimova, IN; Anisimov, VN; Baturin, DA; Manton, KG; Popovich, IG; Semenchenko, AV; Yashin, AI; Zabezhinski, MA, 2003) |
| " Parameters of the model help to describe the possible influences of various stressors, geroprotectors, and their dosage on the life span of laboratory animals." | 1.32 | Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice? ( Anisimov, VN; Semenchenko, GV; Yashin, AI, 2004) |
| "NK mouse model to understand the histological and molecular changes associated with the dose-response pattern of mammary tumor incidence and growth after treatment with a broad range of doses of melatonin." | 1.31 | Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. ( Herbert, RA; Ney, E; Rao, GN, 2000) |
| "Melatonin treatment resulted in a 2." | 1.31 | The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression. ( Alimova, IN; Anisimov, VN; Baturin, DA; Franceschi, C; Mancini, R; Popovich, IG; Provinciali, M; Zabezhinski, MA, 2001) |
| "Melatonin treated rats in either photoperiod showed a significant induction in hepatic and mammary levels of glutathione (GSH) and cytosolic activities of glutathione S-transferase (GST) when compared with the corresponding controls, along with a significant drop in hepatic microsomal contents of cytochromes b5 and P450." | 1.28 | A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis. ( Kothari, L; Subramanian, A, 1992) |
| "Melatonin was administered at a dose of 25 micrograms/mouse/day from 21 to 44 days of age and 50 micrograms/mouse/day from day 45 onwards." | 1.28 | Melatonin, a suppressor of spontaneous murine mammary tumors. ( Kothari, L; Subramanian, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (14.46) | 18.7374 |
| 1990's | 18 (21.69) | 18.2507 |
| 2000's | 28 (33.73) | 29.6817 |
| 2010's | 23 (27.71) | 24.3611 |
| 2020's | 2 (2.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kurhaluk, N | 2 |
| Tkachenko, H | 1 |
| Karadas, AK | 1 |
| Dilmac, S | 1 |
| Aytac, G | 1 |
| Tanriover, G | 1 |
| Baltaci, SB | 1 |
| Mogulkoc, R | 1 |
| Baltaci, AK | 1 |
| Emsen, A | 1 |
| Artac, H | 1 |
| Bojkova, B | 16 |
| Radkowski, M | 1 |
| Zaitseva, OV | 1 |
| Kyriienko, S | 1 |
| Demkow, U | 1 |
| Winklewski, PJ | 1 |
| Colombo, J | 1 |
| Jardim-Perassi, BV | 1 |
| Ferreira, JPS | 1 |
| Braga, CZ | 1 |
| Sonehara, NM | 1 |
| Júnior, RP | 1 |
| Moschetta, MG | 1 |
| Girol, AP | 1 |
| Zuccari, DAPC | 2 |
| Kajo, K | 6 |
| Kubatka, P | 15 |
| Solár, P | 1 |
| Péč, M | 7 |
| Adamkov, M | 5 |
| Lacerda, JZ | 1 |
| Ferreira, LC | 1 |
| Lopes, BC | 1 |
| Aristizábal-Pachón, AF | 1 |
| Bajgelman, MC | 1 |
| Borin, TF | 1 |
| Hill, SM | 10 |
| Cheng, C | 2 |
| Yuan, L | 6 |
| Mao, L | 3 |
| Jockers, R | 2 |
| Dauchy, B | 2 |
| Blask, DE | 9 |
| Schwimmer, H | 2 |
| Metzer, A | 1 |
| Pilosof, Y | 1 |
| Szyf, M | 1 |
| Machnes, ZM | 1 |
| Fares, F | 1 |
| Harel, O | 1 |
| Haim, A | 1 |
| Kennaway, DJ | 1 |
| Orendáš, P | 8 |
| Kassayová, M | 8 |
| Výbohová, D | 3 |
| Kružliak, P | 4 |
| Kapinová, A | 1 |
| Adamicová, K | 2 |
| Sadloňová, V | 1 |
| Chmelová, M | 1 |
| Stollárová, N | 3 |
| Talib, WH | 1 |
| Saleh, S | 1 |
| Ma, C | 1 |
| Li, LX | 1 |
| Zhang, Y | 1 |
| Xiang, C | 1 |
| Ma, T | 1 |
| Ma, ZQ | 1 |
| Zhang, ZP | 1 |
| Bálentová, S | 1 |
| Zulli, A | 1 |
| Demečková, V | 2 |
| Bobrov, N | 3 |
| Strojný, L | 1 |
| Jendželovský, R | 1 |
| Kisková, T | 3 |
| Bomba, A | 1 |
| Fedoročko, P | 1 |
| Moselhy, SS | 1 |
| Al mslmani, MA | 1 |
| Grant, SG | 1 |
| Melan, MA | 1 |
| Latimer, JJ | 1 |
| Witt-Enderby, PA | 1 |
| Ahlers, I | 9 |
| Ahlersova, E | 9 |
| González, A | 2 |
| Alvarez-García, V | 1 |
| Martínez-Campa, C | 2 |
| Mediavilla, MD | 1 |
| Alonso-González, C | 2 |
| Sánchez-Barceló, EJ | 3 |
| Cos, S | 3 |
| Vašková, J | 1 |
| Vaško, L | 1 |
| Frasch, T | 2 |
| Xiang, S | 1 |
| Dauchy, RT | 1 |
| Dauchy, EM | 1 |
| Duplesis, T | 1 |
| Ekmekcioglu, C | 1 |
| Garajová, M | 1 |
| Jäger, W | 1 |
| Thalhammer, T | 1 |
| Nosal, V | 1 |
| Zihlavnikova, K | 1 |
| Karsnakova, R | 1 |
| Kalická, K | 3 |
| Umit, UM | 1 |
| Berna, T | 1 |
| Handan, K | 1 |
| Ipek, E | 1 |
| Berrak, Y | 1 |
| Can, E | 1 |
| Bahadir, GM | 1 |
| Chamilová, M | 2 |
| Adámeková, E | 4 |
| Anisimov, VN | 5 |
| Alimova, IN | 2 |
| Baturin, DA | 2 |
| Popovich, IG | 2 |
| Zabezhinski, MA | 2 |
| Manton, KG | 1 |
| Semenchenko, AV | 1 |
| Yashin, AI | 2 |
| Semenchenko, GV | 1 |
| Saez, MC | 2 |
| Barriga, C | 3 |
| Garcia, JJ | 3 |
| Rodríguez, AB | 3 |
| Ortega, E | 3 |
| Mediavilla, D | 1 |
| Melancon, K | 2 |
| Cheng, Q | 4 |
| Kiefer, TL | 3 |
| Dai, J | 3 |
| Lai, L | 2 |
| Dong, C | 1 |
| Collins, A | 2 |
| Thiyagarajah, A | 1 |
| Long, S | 1 |
| Masot, J | 1 |
| Duran, E | 1 |
| el-Aziz, MA | 1 |
| Hassan, HA | 1 |
| Mohamed, MH | 1 |
| Meki, AR | 1 |
| Abdel-Ghaffar, SK | 1 |
| Hussein, MR | 1 |
| Carrera, MP | 1 |
| Ramírez-Expósito, MJ | 1 |
| Valenzuela, MT | 1 |
| Dueñas, B | 1 |
| García, MJ | 1 |
| Mayas, MD | 1 |
| Martínez-Martos, JM | 1 |
| Sáez, Mdel C | 1 |
| Friedmanová, L | 1 |
| Sahar, S | 1 |
| Sassone-Corsi, P | 1 |
| Mhatre, MC | 2 |
| Shah, PN | 2 |
| Juneja, HS | 1 |
| Kothari, LS | 2 |
| Aubert, C | 1 |
| Janiaud, P | 1 |
| Lecalvez, J | 1 |
| Tamarkin, L | 2 |
| Cohen, M | 1 |
| Roselle, D | 1 |
| Reichert, C | 1 |
| Lippman, M | 1 |
| Chabner, B | 1 |
| Beniashvili, DS | 1 |
| Bulanishvili, VG | 1 |
| Menabde, MZ | 1 |
| Gupta, D | 2 |
| Mevissen, M | 6 |
| Lerchl, A | 3 |
| Szamel, M | 1 |
| Löscher, W | 6 |
| Kothari, A | 1 |
| Borges, A | 1 |
| Ingle, A | 1 |
| Kothari, L | 4 |
| Häussler, B | 1 |
| Häussler, M | 2 |
| Bartsch, C | 4 |
| Bartsch, H | 4 |
| Buchberger, A | 1 |
| Stieglitz, A | 1 |
| Effenberger-Klein, A | 1 |
| Kruse-Jarres, JD | 1 |
| Besenthal, I | 1 |
| Rokos, H | 1 |
| Mecke, D | 3 |
| Thun-Battersby, S | 1 |
| Teplitzky, S | 1 |
| Ram, PT | 1 |
| Kiefer, T | 1 |
| Spriggs, LL | 2 |
| Eck, KM | 1 |
| Teplitzky, SR | 3 |
| Myers, L | 2 |
| Môciková, K | 2 |
| Gajdosová, S | 1 |
| Onderková, HM | 1 |
| Mníchová, M | 1 |
| Szadowska, A | 1 |
| Karasek, M | 1 |
| Geppert, M | 1 |
| Rao, GN | 1 |
| Ney, E | 1 |
| Herbert, RA | 1 |
| M ciková-Kalická, K | 2 |
| Mníchová-Chamilová, M | 2 |
| Cermáková, M | 2 |
| Dwivedi, PD | 1 |
| Moroz, K | 1 |
| Anderson, MB | 2 |
| Deerberg, F | 1 |
| Provinciali, M | 1 |
| Mancini, R | 1 |
| Franceschi, C | 1 |
| Coudert, B | 1 |
| Nowfar, S | 1 |
| Dwived, PD | 1 |
| Bischoff, ED | 1 |
| Moro, K | 1 |
| Karmali, RA | 1 |
| Horrobin, DF | 1 |
| Ghayur, T | 1 |
| Manku, MS | 1 |
| Cunnane, SC | 1 |
| Morgan, RO | 1 |
| Ally, AI | 1 |
| Karmazyn, M | 1 |
| Oka, M | 1 |
| Subramanian, A | 3 |
| Lemus-Wilson, AM | 1 |
| Wilson, ST | 2 |
| Pelletier, DB | 1 |
| Lemus-Wilson, A | 1 |
| Grosso, DS | 1 |
| Wise, ME | 1 |
| Lippert, TH | 1 |
| Wrba, H | 1 |
| Dutter, A | 1 |
| Sánchez de la Peña, S | 1 |
| Wu, J | 1 |
| Carandente, F | 1 |
| Cornélissen, G | 1 |
| Halberg, F | 1 |
| Chang, N | 1 |
| Tseng, MT | 1 |
| Spaulding, TS | 1 |
| Orstead, KM | 1 |
| Massa, JS | 1 |
| Almeida, OF | 1 |
| Danforth, DN | 1 |
| Morozov, VG | 1 |
| Khavinson, VKh | 1 |
| Dil'man, VM | 1 |
| Hamilton, T | 1 |
8 reviews available for melatonin and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.
Topics: Aging; Animals; Breast Neoplasms; Female; Humans; Mammary Neoplasms, Experimental; Melatonin; Mice; | 2013 |
Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.
Topics: Animals; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Controlled Clinical Trials as Topic; | 2009 |
Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer.
Topics: Animals; Breast; Breast Neoplasms; Circadian Clocks; Female; Humans; Mammary Glands, Animal; Mammary | 2011 |
Circadian clock and breast cancer: a molecular link.
Topics: Acetylation; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Bre | 2007 |
Melatonin and mammary pathological growth.
Topics: Animals; Breast Neoplasms; Cell Division; Female; Humans; Mammary Neoplasms, Experimental; Melatonin | 2000 |
Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Cell Division; Drug Syner | 1999 |
Circadian concepts in normal and neoplastic breast.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Chronotherapy; Circadian Rh | 2002 |
Breast cancer: a model system for studying the neuroendocrine role of pineal melatonin in oncology.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Cycle; Cell Line; Female; Humans; Mammary Neoplasms, | 1992 |
75 other studies available for melatonin and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autophagy; Carcinogenesis; Diet, High-Fat; Female; Humans | 2022 |
Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer.
Topics: Angiogenesis Modulating Agents; Animals; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; | 2021 |
The effect of zinc and melatonin supplementation on immunity parameters in breast cancer induced by DMBA in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dietary Supplements; Female; Mammary Neoplasms, Experimen | 2018 |
Melatonin and Metformin Diminish Oxidative Stress in Heart Tissue in a Rat Model of High Fat Diet and Mammary Carcinogenesis.
Topics: Animals; Antioxidants; Catalase; Diet, High-Fat; Female; Glutathione Peroxidase; Heart; Lipid Peroxi | 2018 |
Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening A | 2018 |
Metformin and melatonin improve histopathological outcome of NMU-induced mammary tumors in rats.
Topics: Animals; Cell Proliferation; Diet, High-Fat; Female; Mammary Neoplasms, Experimental; Melatonin; Met | 2019 |
Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cell Proliferation; Drug Screening | 2019 |
Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation.
Topics: Animals; Circadian Rhythm; DNA Methylation; Epigenesis, Genetic; Female; Light; Mammary Neoplasms, E | 2014 |
Light at night, melatonin and breast cancer.
Topics: Animals; Circadian Rhythm; DNA Methylation; Female; Light; Mammary Neoplasms, Experimental; Melatoni | 2014 |
Authors' reply.
Topics: Animals; Circadian Rhythm; DNA Methylation; Female; Light; Mammary Neoplasms, Experimental; Melatoni | 2014 |
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma in Situ; Carci | 2014 |
Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Fe | 2014 |
Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Colorimetry; Female; Huma | 2015 |
Protective and sensitive effects of melatonin combined with adriamycin on ER+ (estrogen receptor) breast cancer.
Topics: Animals; Cadherins; Doxorubicin; Female; Mammary Neoplasms, Experimental; Melatonin; Rats; Rats, Spr | 2015 |
Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer.
Topics: Animals; Antioxidants; Carcinogens; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combinatio | 2016 |
Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer.
Topics: Animals; Antineoplastic Agents; Female; Immunologic Factors; Interleukin-6; Inulin; Lactobacillus pl | 2016 |
Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Carotenoids; Female; Lycopene; | 2008 |
Celecoxib and melatonin in prevention of female rat mammary carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Celecoxib; Drug Therapy, | 2009 |
In vivo inhibition of the estrogen sulfatase enzyme and growth of DMBA-induced mammary tumors by melatonin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Hormonal; Cell Proliferation; Dose | 2010 |
Potential role of melatonin in DNA damage caused by nitrosourea-induced mammary carcinogenesis.
Topics: Animals; Antioxidants; Apoptosis; Comet Assay; DNA Damage; Female; Leukocytes; Mammary Neoplasms, Ex | 2011 |
Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin.
Topics: Age Factors; Animals; Cell Proliferation; Estrogen Receptor alpha; Female; Gene Expression Regulatio | 2011 |
A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.
Topics: Algorithms; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carcinoma; Chemopr | 2012 |
Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Bexa | 2012 |
[Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats].
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Female; Indomethacin; Mammary Neoplasms, Experime | 2012 |
Role of melatonin and luzindole in rat mammary cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Disease Models, Animal; DNA Fragmentation; Estradiol; Female; | 2012 |
Nimesulide and melatonin in mammary carcinogenesis prevention in female Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Carbohydrate Metabolism; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 2002 |
The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice.
Topics: Adenocarcinoma; Animals; Antioxidants; Disease Progression; Female; Homozygote; Mammary Neoplasms, E | 2003 |
Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
Topics: Animals; Dose-Response Relationship, Drug; Female; Genes, erbB-2; Longevity; Mammary Neoplasms, Expe | 2004 |
Effect of the preventive-therapeutic administration of melatonin on mammary tumour-bearing animals.
Topics: Adjuvants, Immunologic; Animals; Female; Injections, Intraperitoneal; Killer Cells, Natural; Macroph | 2005 |
Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Body Weight; Circadian Rhythm; Darkness; | 2006 |
Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.
Topics: Alitretinoin; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Estrogen Receptor | 2005 |
Melatonin increases the survival time of animals with untreated mammary tumours: neuroendocrine stabilization.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catecholamines; Epinephrine; Female; Killer Cells, Natura | 2005 |
The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Estradiol; Female; Lipid Peroxidation; Mammary Neoplasms, Exp | 2005 |
Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.
Topics: Alkylating Agents; Aminopeptidases; Angiotensin II; Animals; Female; Mammary Neoplasms, Experimental | 2006 |
Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epinephrine; Female; Mammary Neoplasms, Expe | 2007 |
Effect of prolonged psychoemotional stress and melatonin on experimental mammary carcinogenesis in female rats.
Topics: Animals; Antioxidants; Carcinogens; Female; Mammary Neoplasms, Experimental; Melatonin; Methylnitros | 2007 |
Effect of varying photoperiods on mammary morphology, DNA synthesis, and hormone profile in female rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromocriptine; Cell Transformation, Neoplastic; Darkness; | 1984 |
Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Darkness; DNA Replication; Estradiol; Female; Light; Mamm | 1984 |
Effect of pinealectomy and melatonin on mammary tumor growth in Sprague-Dawley rats under different conditions of lighting.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Light; Mammary Neoplasms, Experimental; Melatonin | 1980 |
Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Benz(a)Anthracenes; Circadian Rhythm; Fem | 1981 |
[Modifying effect of light and electromagnetic field on development of mammary tumors induced by N-nitrosomethyl urea in female rats].
Topics: Animals; Darkness; Electromagnetic Fields; Female; Lighting; Mammary Neoplasms, Experimental; Melato | 1993 |
Exposure of DMBA-treated female rats in a 50-Hz, 50 microTesla magnetic field: effects on mammary tumor growth, melatonin levels, and T lymphocyte activation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Lymphocyte Activation; Magnetics; Mammary Neoplas | 1996 |
Study on pineal function and DMBA-induced breast cancer formation in rats during exposure to a 100-mG, 50 Hz magnetic field.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Analysis of Variance; Animals; Carcinogens; | 1996 |
Combination of melatonin and tamoxifen as a chemoprophylaxis against N-nitroso-N-methylurea-induced rat mammary tumors.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Female; Mammary Glands, Animal; Mammary | 1997 |
Seasonal influence on 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats under controlled laboratory conditions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Female; Mammary Neopla | 1997 |
Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: replication study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Electromagnetic Fiel | 1998 |
Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Biopterins; Breast Neoplasms; Catecholami | 1999 |
Exposure of Sprague-Dawley rats to a 50-Hertz, 100-microTesla magnetic field for 27 weeks facilitates mammary tumorigenesis in the 7,12-dimethylbenz[a]-anthracene model of breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Carcinogens; Circadian Rhythm; C | 1999 |
Alterations in ornithine decarboxylase activity in the rat mammary gland after different periods of 50 Hz magnetic field exposure.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Female; Mag | 1999 |
Melatonin and 9-cis-retinoic acid in the chemoprevention of NMU-induced rat mammary carcinoma.
Topics: Adenocarcinoma; Alitretinoin; Animals; Anticarcinogenic Agents; Female; Mammary Neoplasms, Experimen | 1999 |
Melatonin and retinyl acetate as chemopreventives in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diterpenes; Drug Sy | 2000 |
Effects of retinyl acetate and melatonin on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. A preliminary report.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Diterpenes; Drug Synergism; Female; Injections, | 2000 |
Serial transplants of DMBA-induced mammary tumors in fischer rats as model system for human breast cancer: V. Myoepithelial-mesenchymal conversion during passaging as possible cause for modulation of pineal-tumor interaction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Adenocarcinoma; Animals; Disease Models, Animal; Epitheliu | 2000 |
Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene.
Topics: alpha-Linolenic Acid; Animals; Antioxidants; Diet; Dose-Response Relationship, Drug; Female; Genes, | 2000 |
Effects of tamoxifen and melatonin on mammary gland cancer induced by N-methyl-N-nitrosourea and by 7,12-dimethylbenz(a)anthracene, respectively, in female Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Estrogen Receptor Modulators; Female; Mammar | 2001 |
Preventive effect of indomethacin and melatonin on 7, 12-dimethybenz/a/anthracene-induced mammary carcinogenesis in female Sprague-Dawley rats. A preliminary report.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Female; Indomethaci | 2001 |
Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.
Topics: Adenocarcinoma; Alitretinoin; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoge | 2001 |
Seasonal rhythms of 6-sulphatoxymelatonin (aMT6s) excretion in female rats are abolished by growth of malignant tumors.
Topics: Animals; Endometrial Neoplasms; Female; Mammary Neoplasms, Experimental; Melatonin; Neoplasms, Exper | 2001 |
Preventive effects of raloxifene and melatonin in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Drinking; Eating; Female; Kinetics; Mammary Neoplasms | 2001 |
The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression.
Topics: Age Factors; Animals; Antioxidants; Female; Gene Expression Regulation, Neoplastic; Mammary Neoplasm | 2001 |
Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin.
Topics: Administration, Oral; Alitretinoin; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Dis | 2002 |
Role of pineal gland in aetiology and treatment of breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Estrogens; Female; Hormones; Humans; Mammary Neopl | 1978 |
Influence of agents which modulate thromboxane A2 synthesis or action on R3230AC mammary carcinoma.
Topics: Animals; Colchicine; Copper; Diazepam; Dipyridamole; Female; Mammary Neoplasms, Experimental; Melato | 1978 |
A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cytochrome P-450 Enzyme System; | 1992 |
Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo.
Topics: Animals; Disease Models, Animal; Estradiol; Female; Mammary Neoplasms, Experimental; Melatonin; Meth | 1991 |
Suppressive effect by melatonin on different phases of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced rat mammary gland carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Light; Mammary Glands, Animal; Mammary Neoplasms, | 1991 |
Melatonin, a suppressor of spontaneous murine mammary tumors.
Topics: Administration, Oral; Animals; DNA, Neoplasm; Estradiol; Female; Incidence; Mammary Neoplasms, Exper | 1991 |
Effect of the mammary carcinogen 7,12-dimethylbenz[a]anthracene on pineal melatonin biosynthesis, secretion and peripheral metabolism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Circadian Rhythm; Estradiol; Female; Kinetics; Mammary Ne | 1990 |
Secular or circannual effects of placebo and melatonin on murine breast cancer?
Topics: Animals; Circadian Rhythm; Female; Mammary Neoplasms, Experimental; Melatonin; Mice; Periodicity; Se | 1990 |
Induction and growth of mammary tumors after superior cervical ganglionectomy in sighted and blinded-anosmic rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylserotonin O-Methyltransferase; Animals; Female; Hypothalamus | 1986 |
Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7,12-dimethylbenzanthracene-(DMBA)-induced mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cell Transformation, Neoplastic; Female; Foo | 1986 |
Influence of chronic melatonin on 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors in female Holtzman rats exposed to continuous light.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Light; Mammary Neoplasms, Experimental; Melatonin | 1987 |
Melatonin and malignant disease.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Cell Line; Female; Hormones; Humans; Ma | 1985 |
[Comparison of the anti-tumor activity of extracts of the epiphysis and hypothalamus, melatonin and sigetin in mice with transplanted mammary gland cancer].
Topics: Alkanes; Animals; Benzene Derivatives; Disulfides; Estrogens; Hypothalamus; Male; Mammary Neoplasms, | 1973 |
Influence of environmental light and melatonin upon mammary tumour induction.
Topics: Adenocarcinoma; Adenofibroma; Animals; Benz(a)Anthracenes; Carcinoma; Female; Light; Mammary Neoplas | 1969 |