melatonin has been researched along with Esophageal Reflux in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin has a role in the improvement of Gastro-esophageal reflux disease when used alone or in combination with omeprazole." | 9.14 | The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. ( Abbas, AM; El-Gendy, AA; Kandil, TS; Mousa, AA, 2010) |
| "Our results suggest that COX-2 plays an important pro-inflammatory role during acute reflux oesophagitis in rats and its inhibition contributes significantly to melatonin-exerted protection against reflux oesophagitis." | 7.77 | Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats. ( Palit, G; Singh, N; Singh, P, 2011) |
| "Melatonin has known inhibitory activities on gastric acid secretion and nitric oxide biosynthesis." | 6.72 | Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. ( Pereira, Rde S, 2006) |
| "Melatonin is a potent reactive oxygen metabolite scavenger and antioxidant that has been shown to influence many physiological functions of the gastrointestinal (GI) tract including secretion, motility, digestion and absorption of nutrients." | 6.50 | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. ( Brzozowska, I; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Strzalka, M, 2014) |
| "Gastroesophageal reflux disease (GERD) is also known to have association with sleep disturbance." | 5.51 | Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis. ( Baik, GH; Bang, CS; Yang, YJ, 2019) |
| "Melatonin has a role in the improvement of Gastro-esophageal reflux disease when used alone or in combination with omeprazole." | 5.14 | The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. ( Abbas, AM; El-Gendy, AA; Kandil, TS; Mousa, AA, 2010) |
| "With emphasis on reflux and non-cardiac chest pain, research is ongoing into the clinical utility and diverse physiologic mechanisms underlying a variety of complementary and alternative modalities, including dietary manipulation, apple cider vinegar, melatonin, acupuncture, and various herbal products (rikkunshito, STW 5, slippery elm, licorice, and peppermint oil, among others)." | 5.01 | Popular Remedies for Esophageal Symptoms: a Critical Appraisal. ( Ahuja, A; Ahuja, NK, 2019) |
| "Our results suggest that COX-2 plays an important pro-inflammatory role during acute reflux oesophagitis in rats and its inhibition contributes significantly to melatonin-exerted protection against reflux oesophagitis." | 3.77 | Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats. ( Palit, G; Singh, N; Singh, P, 2011) |
| "Melatonin is a potent reactive oxygen metabolite scavenger and antioxidant that has been shown to influence many physiological functions of the gastrointestinal (GI) tract including secretion, motility, digestion and absorption of nutrients." | 2.50 | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. ( Brzozowska, I; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Strzalka, M, 2014) |
| "Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases." | 2.50 | Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014) |
| "Gastroesophageal reflux disorder (GERD), a common disorder in the Western world, can lead to complications that include esophageal stricture and esophageal adenocarcinoma." | 2.47 | Gastroesophageal reflux disease (GERD): a review of conventional and alternative treatments. ( Patrick, L, 2011) |
| "Four hundred patients with bronchial asthma (BA) were questioned." | 1.33 | [Clinicodiagnostic significance of gastroesophageal reflux and structural changes in the esophagus and stomach in bronchial asthma]. ( Kozlova, IV; Kvetnoĭ, IM; Pakhomova, AL; Slavkina, EA, 2006) |
| "In patients with GERD and DUD melatonin concentration was lower than in healthy subjects - 27,2 +/- 8,5 pg/ml and 25,5 +/- 6,2 pg/ml respectively (p < 0,05; p < 0,01)." | 1.33 | Nocturnal secretion of melatonin in patients with upper digestive tract disorders. ( Błasiak, J; Chojnacki, C; Chojnacki, J; Harasiuk, A; Klupińska, G; Reiter, RJ; Stec-Michalska, K; Wiśniewska-Jarosińska, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bang, CS | 1 |
| Yang, YJ | 1 |
| Baik, GH | 1 |
| Ahuja, A | 1 |
| Ahuja, NK | 1 |
| Brzozowska, I | 1 |
| Strzalka, M | 1 |
| Drozdowicz, D | 1 |
| Konturek, SJ | 2 |
| Brzozowski, T | 2 |
| Miano, S | 1 |
| Peraita-Adrados, R | 1 |
| Tan, J | 1 |
| Wang, Y | 1 |
| Xia, Y | 1 |
| Zhang, N | 1 |
| Sun, X | 1 |
| Yu, T | 1 |
| Lin, L | 1 |
| Kandil, TS | 1 |
| Mousa, AA | 1 |
| El-Gendy, AA | 1 |
| Abbas, AM | 1 |
| Patrick, L | 1 |
| Singh, P | 1 |
| Singh, N | 1 |
| Palit, G | 1 |
| Kozlova, IV | 1 |
| Kvetnoĭ, IM | 1 |
| Slavkina, EA | 1 |
| Pakhomova, AL | 1 |
| de Souza Pereira, R | 1 |
| Pereira, Rde S | 1 |
| Klupińska, G | 1 |
| Wiśniewska-Jarosińska, M | 1 |
| Harasiuk, A | 1 |
| Chojnacki, C | 1 |
| Stec-Michalska, K | 1 |
| Błasiak, J | 1 |
| Reiter, RJ | 1 |
| Chojnacki, J | 1 |
| Zayachkivska, O | 1 |
| Havryluk, XO | 1 |
| Sliwowski, Z | 1 |
| Pawlik, M | 1 |
| Konturek, PC | 1 |
| Cześnikiewicz-Guzik, M | 1 |
| Gzhegotsky, MR | 1 |
| Pawlik, WW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease[NCT00915616] | Phase 3 | 0 participants | Interventional | Withdrawn | |||
| The Effects of Melatonin on GERD Symptoms and Esophageal Acid Exposure[NCT00564590] | Phase 1/Phase 2 | 150 participants (Anticipated) | Interventional | 2008-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for melatonin and Esophageal Reflux
| Article | Year |
|---|---|
Popular Remedies for Esophageal Symptoms: a Critical Appraisal.
Topics: Acetic Acid; Acupuncture Therapy; Chest Pain; Complementary Therapies; Drugs, Chinese Herbal; Gastro | 2019 |
Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease.
Topics: Esophagus; Gastroesophageal Reflux; Humans; Melatonin; Peptic Ulcer | 2014 |
Pediatric insomnia: clinical, diagnosis, and treatment.
Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di | 2014 |
Gastroesophageal reflux disease (GERD): a review of conventional and alternative treatments.
Topics: Acupuncture Therapy; Antacids; Anti-Ulcer Agents; Artemisia; Curcumin; Cyclohexenes; Gastroesophagea | 2011 |
2 trials available for melatonin and Esophageal Reflux
| Article | Year |
|---|---|
The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.
Topics: Drug Therapy, Combination; Gastrins; Gastroesophageal Reflux; Humans; Melatonin; Omeprazole; Treatme | 2010 |
Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole.
Topics: Adult; Amino Acids; Anti-Ulcer Agents; Dietary Supplements; Female; Gastroesophageal Reflux; Humans; | 2006 |
7 other studies available for melatonin and Esophageal Reflux
| Article | Year |
|---|---|
Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis.
Topics: Central Nervous System Depressants; Gastroesophageal Reflux; Humans; Melatonin; Meta-Analysis as Top | 2019 |
Melatonin protects the esophageal epithelial barrier by suppressing the transcription, expression and activity of myosin light chain kinase through ERK1/2 signal transduction.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Epithelial Cells; Female; Gastroesophageal Reflux; Gene | 2014 |
Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats.
Topics: Animals; Antioxidants; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme A | 2011 |
[Clinicodiagnostic significance of gastroesophageal reflux and structural changes in the esophagus and stomach in bronchial asthma].
Topics: Adult; Algorithms; Asthma; Calbindin 2; Endothelin-1; Esophagus; Female; Gastroesophageal Reflux; Hu | 2006 |
Regression of an esophageal ulcer using a dietary supplement containing melatonin.
Topics: Adult; Dietary Supplements; Esophageal Diseases; Gastroesophageal Reflux; Humans; Male; Melatonin; U | 2006 |
Nocturnal secretion of melatonin in patients with upper digestive tract disorders.
Topics: Adult; Circadian Rhythm; Duodenal Ulcer; Dyspepsia; Female; Gastroesophageal Reflux; Gastrointestina | 2006 |
Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves.
Topics: Acute Disease; Animals; Dinoprostone; Esophagus; Gastroesophageal Reflux; Male; Melatonin; Neurons, | 2007 |