melatonin has been researched along with Endotoxemia in 20 studies
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 7.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| "Melatonin does not affect DIC but diminishes thrombocytopenia and haemolysis during endotoxaemia." | 7.83 | Melatonin does not affect disseminated intravascular coagulation but diminishes decreases in platelet count during subacute endotoxaemia in rats. ( de Groot, H; Effenberger-Neidnicht, K; Görlinger, K; Hartmann, M; Lansink, MO, 2016) |
| "In the literature, few studies have investigated the effects of melatonin on energy metabolism in skeletal muscle in endotoxemia." | 7.83 | Amelioration of energy metabolism by melatonin in skeletal muscle of rats with LPS induced endotoxemia. ( Aksu, A; Ates, G; Balkis, N; Ozkok, E; Şahin, Ö; Tamer, S; Yorulmaz, H, 2016) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 7.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Melatonin reduces acute lung injury in endotoxemic rats by attenuating pulmonary inflammation and inhibiting NF-kappaB activation." | 7.75 | Melatonin reduces acute lung injury in endotoxemic rats. ( Jiang, YX; Shang, Y; Wu, Y; Wu, ZY; Xu, SP; Yao, SL; Yuan, SY, 2009) |
| " The animals were randomized into three experimental groups: (1) controls; (2) endotoxemia; (3) endotoxemia treated with melatonin (10mg/kg)." | 7.74 | The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats. ( Acikgoz, O; Aksu, I; Gonenc, S; Ozdemir, D; Ozkan, H; Tugyan, K; Uysal, N, 2007) |
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 7.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| "Melatonin treatment had significant effects on mitochondrial oxidation of the NADH-generated substrate, and it also decreased mitochondrial ability to oxidize FAD-generated substrate and mitochondrial coupling in both LPS- and AES-induced oxidative stress." | 5.56 | Melatonin modulates oxidative phosphorylation, hepatic and kidney autophagy-caused subclinical endotoxemia and acute ethanol-induced oxidative stress. ( Kurhaluk, N; Lukash, O; Tkachenko, H, 2020) |
| "Melatonin was applied directly before and 2 h after LPS administration (3 mg/kg, each)." | 5.40 | Immune stimulation by exogenous melatonin during experimental endotoxemia. ( Brencher, L; Broecker-Preuss, M; de Groot, H; Effenberger-Neidnicht, K; Hamburger, T; Petrat, F, 2014) |
| "We aimed to investigate the effects of melatonin administered before and during endotoxemia on the lung tissue of rats, cytokine, YKL-40, matrix metalloproteinase (MMP) and inhibitor levels, oxidative stress parameters, and energy balance." | 4.12 | Melatonin pretreatment modulates anti-inflammatory, antioxidant, YKL-40, and matrix metalloproteinases in endotoxemic rat lung tissue. ( Aksu, A; Ates, G; Caglar, NB; Mutlu, S; Olgac, V; Özkök, E; Tamer, S; Yorulmaz, H, 2022) |
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 3.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| "Melatonin does not affect DIC but diminishes thrombocytopenia and haemolysis during endotoxaemia." | 3.83 | Melatonin does not affect disseminated intravascular coagulation but diminishes decreases in platelet count during subacute endotoxaemia in rats. ( de Groot, H; Effenberger-Neidnicht, K; Görlinger, K; Hartmann, M; Lansink, MO, 2016) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 3.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Melatonin reduces acute lung injury in endotoxemic rats by attenuating pulmonary inflammation and inhibiting NF-kappaB activation." | 3.75 | Melatonin reduces acute lung injury in endotoxemic rats. ( Jiang, YX; Shang, Y; Wu, Y; Wu, ZY; Xu, SP; Yao, SL; Yuan, SY, 2009) |
| " The animals were randomized into three experimental groups: (1) controls; (2) endotoxemia; (3) endotoxemia treated with melatonin (10mg/kg)." | 3.74 | The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats. ( Acikgoz, O; Aksu, I; Gonenc, S; Ozdemir, D; Ozkan, H; Tugyan, K; Uysal, N, 2007) |
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 3.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| "Melatonin was applied directly before and 2 h after LPS administration (3 mg/kg, each)." | 1.40 | Immune stimulation by exogenous melatonin during experimental endotoxemia. ( Brencher, L; Broecker-Preuss, M; de Groot, H; Effenberger-Neidnicht, K; Hamburger, T; Petrat, F, 2014) |
| "Melatonin was administered by intraperitoneal injection 30 min before endotoxin inoculation to animals." | 1.33 | Beneficial effects of melatonin on diaphragmatic contractility and fatigability in Escherichia coli endotoxemic rats. ( Iraz, M; Kelesyilmaz, N; Kilic, N; Kurcer, Z; Olmez, E, 2006) |
| "Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, J | 1 |
| Cheng, M | 1 |
| Xu, Y | 1 |
| Chen, Y | 1 |
| Gao, T | 1 |
| Gu, Q | 1 |
| Yu, W | 1 |
| Ates, G | 2 |
| Tamer, S | 2 |
| Yorulmaz, H | 2 |
| Mutlu, S | 1 |
| Olgac, V | 1 |
| Aksu, A | 2 |
| Caglar, NB | 1 |
| Özkök, E | 2 |
| Kurhaluk, N | 1 |
| Tkachenko, H | 1 |
| Lukash, O | 1 |
| Brencher, L | 2 |
| Oude Lansink, M | 1 |
| Effenberger-Neidnicht, K | 3 |
| Alamili, M | 2 |
| Klein, M | 1 |
| Lykkesfeldt, J | 1 |
| Rosenberg, J | 1 |
| Gögenur, I | 1 |
| Broecker-Preuss, M | 1 |
| Hamburger, T | 1 |
| Petrat, F | 1 |
| de Groot, H | 2 |
| Swanson, GR | 1 |
| Gorenz, A | 1 |
| Shaikh, M | 1 |
| Desai, V | 1 |
| Forsyth, C | 1 |
| Fogg, L | 1 |
| Burgess, HJ | 1 |
| Keshavarzian, A | 2 |
| Kawada, T | 1 |
| Swanson, G | 1 |
| Rizvydeen, M | 1 |
| Burgess, H | 1 |
| Lansink, MO | 1 |
| Görlinger, K | 1 |
| Hartmann, M | 1 |
| Balkis, N | 1 |
| Şahin, Ö | 1 |
| Shang, Y | 1 |
| Xu, SP | 1 |
| Wu, Y | 1 |
| Jiang, YX | 1 |
| Wu, ZY | 1 |
| Yuan, SY | 1 |
| Yao, SL | 1 |
| Scheff, JD | 1 |
| Calvano, SE | 1 |
| Lowry, SF | 1 |
| Androulakis, IP | 1 |
| Xing, HY | 1 |
| Ling, YL | 1 |
| Meng, AH | 1 |
| Zhao, XY | 1 |
| Huang, XL | 1 |
| Kurcer, Z | 1 |
| Iraz, M | 1 |
| Kelesyilmaz, N | 1 |
| Kilic, N | 1 |
| Olmez, E | 1 |
| Escames, G | 2 |
| López, LC | 1 |
| Ortiz, F | 1 |
| Ros, E | 1 |
| Acuña-Castroviejo, D | 2 |
| Ozdemir, D | 1 |
| Uysal, N | 1 |
| Tugyan, K | 1 |
| Gonenc, S | 1 |
| Acikgoz, O | 1 |
| Aksu, I | 1 |
| Ozkan, H | 1 |
| Crespo, E | 1 |
| Macías, M | 1 |
| Pozo, D | 1 |
| Martín, M | 1 |
| Vives, F | 1 |
| Guerrero, JM | 1 |
| Wu, CC | 1 |
| Chiao, CW | 1 |
| Hsiao, G | 1 |
| Chen, A | 1 |
| Yen, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Remote Physiologic Monitoring to Detect Inflammatory Bowel Disease (IBD) Flares: A Feasibility Study[NCT04333810] | 8 participants (Actual) | Observational | 2020-10-01 | Completed | |||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 other studies available for melatonin and Endotoxemia
| Article | Year |
|---|---|
Exogenous Melatonin Alleviates Skeletal Muscle Wasting by Regulating Hypothalamic Neuropeptides Expression in Endotoxemia Rats.
Topics: Animals; Endotoxemia; Hypothalamus; Male; Melatonin; Muscle, Skeletal; Muscular Atrophy; Neuropeptid | 2022 |
Melatonin pretreatment modulates anti-inflammatory, antioxidant, YKL-40, and matrix metalloproteinases in endotoxemic rat lung tissue.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Antio | 2022 |
Melatonin modulates oxidative phosphorylation, hepatic and kidney autophagy-caused subclinical endotoxemia and acute ethanol-induced oxidative stress.
Topics: Animals; Antioxidants; Autophagy; Circadian Rhythm; Endotoxemia; Ethanol; Kidney; Lipid Peroxidation | 2020 |
Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial.
Topics: Animals; Endotoxemia; Inflammation; Lipopolysaccharides; Male; Melatonin; Rats; Rats, Wistar; Sepsis | 2017 |
Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin.
Topics: Acute-Phase Reaction; Animals; Antioxidants; Ascorbic Acid; Circadian Rhythm; Darkness; Disease Mode | 2013 |
Immune stimulation by exogenous melatonin during experimental endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Endotoxemia; Inflammation; Lipopolysaccharides; Male; | 2014 |
Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics.
Topics: Acute-Phase Proteins; Adult; Aged; Aged, 80 and over; Carrier Proteins; Cell Membrane Permeability; | 2015 |
Circadian variation in endotoxaemia and modulatory effects of melatonin.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Circadian Rhythm; Cytokines; Endotoxemia; Humans; M | 2015 |
Sleep parameters by actigraphy and relationship between plasma melatonin and intestinal permeability in alcoholics.
Topics: Cell Membrane Permeability; Endotoxemia; Female; Humans; Intestinal Absorption; Intestinal Mucosa; L | 2015 |
Response to Dr. Kawada.
Topics: Cell Membrane Permeability; Endotoxemia; Female; Humans; Intestinal Absorption; Intestinal Mucosa; L | 2015 |
Melatonin does not affect disseminated intravascular coagulation but diminishes decreases in platelet count during subacute endotoxaemia in rats.
Topics: Animals; Blood Platelets; Blood Pressure; Disseminated Intravascular Coagulation; Endotoxemia; Hemol | 2016 |
Amelioration of energy metabolism by melatonin in skeletal muscle of rats with LPS induced endotoxemia.
Topics: Animals; Antioxidants; Endotoxemia; Energy Metabolism; Glutathione; Lipopolysaccharides; Male; Melat | 2016 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Modeling the influence of circadian rhythms on the acute inflammatory response.
Topics: Algorithms; Animals; Circadian Rhythm; Computer Simulation; Cytokines; Endotoxemia; Humans; Hydrocor | 2010 |
[Melatonin improves vascular reactivity of endotoxemia rats].
Topics: Animals; Aorta, Thoracic; Endotoxemia; Free Radical Scavengers; Lipopolysaccharides; Male; Melatonin | 2005 |
Beneficial effects of melatonin on diaphragmatic contractility and fatigability in Escherichia coli endotoxemic rats.
Topics: Animals; Antioxidants; Diaphragm; Endotoxemia; Female; Lipid Peroxidation; Lipopolysaccharides; Malo | 2006 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Endotoxemia; Intestinal Mucosa; Lipid Peroxidati | 2007 |
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Drug Administration Schedule; Endotoxemia; Gene Expression Regulation, Enzymologic; Kidney; | 1999 |
Melatonin prevents endotoxin-induced circulatory failure in rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Blotting, Western; Chemotaxis, Leukocyte; Endotoxemia; Esche | 2001 |