melatonin has been researched along with Edema in 24 studies
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene expressions, and the protective effects of melatonin in rat hearts administered with cisplatin." | 8.02 | The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin. ( Adali, Y; Karakilic, E; Koral, L; Ovali, MA; Tufekcioglu, NK; Uzun, M, 2021) |
| "7 macrophages and croton oil-induced ear edema in mice." | 8.02 | Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema. ( Damrongrungruang, T; Mahakunakorn, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P, 2021) |
| "Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties." | 7.96 | Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis. ( Daduang, J; Damrongrungruang, T; Mahakunakorn, P; Panpitakkul, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P; Somudorn, J; Uthaiwat, P, 2020) |
| "Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults." | 7.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats." | 7.81 | Anti-edema effect of melatonin on spinal cord injury in rats. ( Hou, M; Liu, X; Liu, Y; Wang, Y; Xiang, L; Yang, J; Zhou, D, 2015) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 7.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene expressions, and the protective effects of melatonin in rat hearts administered with cisplatin." | 4.02 | The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin. ( Adali, Y; Karakilic, E; Koral, L; Ovali, MA; Tufekcioglu, NK; Uzun, M, 2021) |
| "7 macrophages and croton oil-induced ear edema in mice." | 4.02 | Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema. ( Damrongrungruang, T; Mahakunakorn, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P, 2021) |
| "Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties." | 3.96 | Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis. ( Daduang, J; Damrongrungruang, T; Mahakunakorn, P; Panpitakkul, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P; Somudorn, J; Uthaiwat, P, 2020) |
| "Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults." | 3.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "The aim of this study was to estimate the effect of melatonin on spinal cord perfusion, the permeability of blood-spinal cord barrier (BSCB), and edema at the contusion epicenter and regions rostral and caudal to the injury site in rats with spinal cord injury (SCI)." | 3.83 | Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry. ( Bai, F; Chen, H; Dong, H; Jing, Y, 2016) |
| "To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats." | 3.81 | Anti-edema effect of melatonin on spinal cord injury in rats. ( Hou, M; Liu, X; Liu, Y; Wang, Y; Xiang, L; Yang, J; Zhou, D, 2015) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| "The anti-inflammatory activity of melatonin (CAS 73-31-4) was examined, using the rat paw edema model, and compared with the non-steroidal anti-inflammatory drug (NSAID) indometacin (CAS 53-86-1) which exerts its effects by inhibition of prostaglandin production on acute inflammation." | 3.74 | Structural basis of the anti-inflammatory activity of melatonin. ( Aguilar, CF; de la Rocha, N; Pelzer, L; Rotelli, A, 2007) |
| " In the present study we have evaluated the anti-inflammatory and antinociceptive activity of oxytocin and melatonin against rat paw edema induced by dried latex (DL) of C procera and compared it with that against carrageenan-induced paw edema." | 3.73 | Inhibition of Calotropis procera latex-induced inflammatory hyperalgesia by oxytocin and melatonin. ( Kumar, VL; Padhy, BM, 2005) |
| "The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat." | 3.72 | Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004) |
| " Methylprednisolone (MP), by reducing edema and protecting the cell membrane against peroxidation, is the only pharmacological agent with a proven clinically beneficial effect on SCI." | 3.72 | Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. ( Batcioglu, K; Cayli, SR; Erbil, M; Kocak, A; Ozturk, C; Tekiner, A; Yilmaz, U; Yologlu, S, 2004) |
| "The aim of the present study was to investigate the protective effect of the pineal hormone melatonin in a model of acute local inflammation (carrageenan-induced paw oedema)." | 3.71 | Protective effect of melatonin in carrageenan-induced acute local inflammation. ( Akpinar, E; Bilici, D; Kiziltunç, A, 2002) |
| "The aim of the present study was to investigate the protective effect of the pineal hormone melatonin in a model of acute local inflammation (zymosan-activated plasma-induced paw oedema), in which oxyradicals, nitric oxide (NO) and peroxynitrite are known to play a crucial role in the inflammatory process." | 3.70 | Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation. ( Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E, 1998) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 3.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "Melatonin was administered 1, 24, 48 and 72 h after TBI through i." | 1.48 | Does the administration of melatonin during post-traumatic brain injury affect cytokine levels? ( Asadikorom, G; Dehghan, F; Khaksari, M; Najafi, A; Shahrokhi, N; Soltani, Z, 2018) |
| "Treatment with melatonin improved oxygenation and decreased histological lung injury but significantly increased oxidative stress quantified by malondialdehyde levels." | 1.35 | Effects of melatonin in an experimental model of ventilator-induced lung injury. ( Albaiceta, GM; Astudillo, A; Diaz, E; García-Prieto, E; Parra, D; Pedreira, PR; Taboada, F, 2008) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 12 (50.00) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Elmegeed, GA | 1 |
| Baiuomy, AR | 4 |
| Abdel-Salam, OM | 4 |
| Koral, L | 1 |
| Ovali, MA | 1 |
| Tufekcioglu, NK | 1 |
| Karakilic, E | 1 |
| Adali, Y | 1 |
| Uzun, M | 1 |
| Refahee, SM | 1 |
| Aboulmagd, I | 1 |
| Ragab, R | 1 |
| Abdel Aziz, O | 1 |
| Ahmed, WAEA | 1 |
| Shabaan, AA | 1 |
| Damrongrungruang, T | 2 |
| Panpitakkul, P | 1 |
| Somudorn, J | 1 |
| Sangchart, P | 2 |
| Mahakunakorn, P | 2 |
| Uthaiwat, P | 1 |
| Daduang, J | 1 |
| Panyatip, P | 2 |
| Puthongking, P | 2 |
| Priprem, A | 2 |
| Xu, LX | 1 |
| Lv, Y | 1 |
| Li, YH | 1 |
| Ding, X | 1 |
| Wang, Y | 2 |
| Han, X | 1 |
| Liu, MH | 1 |
| Sun, B | 1 |
| Feng, X | 1 |
| Dehghan, F | 1 |
| Shahrokhi, N | 2 |
| Khaksari, M | 1 |
| Soltani, Z | 1 |
| Asadikorom, G | 1 |
| Najafi, A | 1 |
| Liu, X | 1 |
| Yang, J | 1 |
| Liu, Y | 1 |
| Zhou, D | 1 |
| Hou, M | 1 |
| Xiang, L | 1 |
| Qiao, YF | 1 |
| Guo, WJ | 1 |
| Li, L | 1 |
| Shao, S | 1 |
| Qiao, X | 1 |
| Shao, JJ | 1 |
| Zhang, Q | 1 |
| Li, RS | 1 |
| Wang, LH | 1 |
| Jing, Y | 1 |
| Bai, F | 1 |
| Chen, H | 1 |
| Dong, H | 1 |
| Pedreira, PR | 1 |
| García-Prieto, E | 1 |
| Parra, D | 1 |
| Astudillo, A | 1 |
| Diaz, E | 1 |
| Taboada, F | 1 |
| Albaiceta, GM | 1 |
| Marino, A | 1 |
| Di Paola, R | 1 |
| Crisafulli, C | 1 |
| Mazzon, E | 2 |
| Morabito, R | 1 |
| Paterniti, I | 1 |
| Galuppo, M | 1 |
| Genovese, T | 1 |
| La Spada, G | 1 |
| Cuzzocrea, S | 3 |
| Sulli, A | 1 |
| Maestroni, GJ | 1 |
| Villaggio, B | 1 |
| Hertens, E | 1 |
| Craviotto, C | 1 |
| Pizzorni, C | 1 |
| Briata, M | 1 |
| Seriolo, B | 1 |
| Cutolo, M | 1 |
| Bilici, D | 1 |
| Akpinar, E | 1 |
| Kiziltunç, A | 1 |
| El-Shenawy, SM | 1 |
| El-Batran, S | 2 |
| Arbid, MS | 3 |
| Cayli, SR | 1 |
| Kocak, A | 1 |
| Yilmaz, U | 1 |
| Tekiner, A | 1 |
| Erbil, M | 1 |
| Ozturk, C | 1 |
| Batcioglu, K | 1 |
| Yologlu, S | 1 |
| Padhy, BM | 1 |
| Kumar, VL | 1 |
| Nesic, O | 1 |
| Lee, J | 1 |
| Unabia, GC | 1 |
| Johnson, K | 1 |
| Ye, Z | 1 |
| Vergara, L | 1 |
| Hulsebosch, CE | 1 |
| Perez-Polo, JR | 1 |
| de la Rocha, N | 1 |
| Rotelli, A | 1 |
| Aguilar, CF | 1 |
| Pelzer, L | 1 |
| Zingarelli, B | 1 |
| Gilad, E | 1 |
| Hake, P | 1 |
| Salzman, AL | 1 |
| Szabó, C | 1 |
| Costantino, G | 1 |
| Caputi, AP | 1 |
| Qi, W | 1 |
| Tan, DX | 1 |
| Reiter, RJ | 1 |
| Kim, SJ | 1 |
| Manchester, LC | 1 |
| Cabrera, J | 1 |
| Sainz, RM | 1 |
| Mayo, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for melatonin and Edema
| Article | Year |
|---|---|
The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar.
Topics: Adult; Anti-Inflammatory Agents; Cellulose; Edema; Female; Humans; Male; Mandible; Melatonin; Molar, | 2023 |
23 other studies available for melatonin and Edema
| Article | Year |
|---|---|
Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Edema; Extremities; Melatonin; Mice; Mo | 2007 |
The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin.
Topics: Animals; Aquaporin 3; Aquaporin 4; Cardiotonic Agents; Cisplatin; Edema; Heart Diseases; Melatonin; | 2021 |
Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis.
Topics: Administration, Topical; Anhydrides; Animals; Anti-Inflammatory Agents; Antifungal Agents; Candida a | 2020 |
Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema.
Topics: Animals; Anti-Inflammatory Agents; Benzoates; Croton Oil; Edema; Halogenation; Lipopolysaccharides; | 2021 |
Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Brain Edema; Colonic Diseases; Edema; Hypo | 2017 |
Does the administration of melatonin during post-traumatic brain injury affect cytokine levels?
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Anim | 2018 |
Anti-edema effect of melatonin on spinal cord injury in rats.
Topics: Animals; Antioxidants; Aquaporin 4; Body Water; Down-Regulation; Edema; Glial Fibrillary Acidic Prot | 2015 |
Melatonin attenuates hypertension-induced renal injury partially through inhibiting oxidative stress in rats.
Topics: Animals; Blood Pressure; Creatinine; Edema; Gene Expression Regulation; Heme Oxygenase-1; Hypertensi | 2016 |
Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Disease Models, Animal; Edema; Female; Laser-Doppler Flo | 2016 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Protective effect of melatonin against the inflammatory response elicited by crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa).
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Chymases; Cnidarian Venoms; Edema; Histocytochemistry; | 2009 |
Melatonin serum levels in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Circadian Rhythm; Cytokines; Edema; Female; | 2002 |
Protective effect of melatonin in carrageenan-induced acute local inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relation | 2002 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc | 2004 |
Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2004 |
Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Drug Therapy, Combination; Edema; Evoked Potentials, Motor; | 2004 |
Inhibition of Calotropis procera latex-induced inflammatory hyperalgesia by oxytocin and melatonin.
Topics: Analgesics; Animals; Calotropis; Carrageenan; Edema; Hyperalgesia; Latex; Latex Hypersensitivity; Ma | 2005 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Structural basis of the anti-inflammatory activity of melatonin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 In | 2007 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 1997 |
Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Dose-Response Relationship, Drug; Edema; Foot; Free R | 1998 |
Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Edema; Free Radical Scavengers; Lipid Peroxidation; Ma | 1999 |