Page last updated: 2024-10-19

melatonin and Eczema, Atopic

melatonin has been researched along with Eczema, Atopic in 18 studies

Research Excerpts

ExcerptRelevanceReference
"Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis."5.48Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018)
"Melatonin also has sleep-inducing and anti-inflammatory properties and therefore might be useful for the management of AD."2.82Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial. ( Chang, YS; Chen, CA; Chiang, BL; Chu, KH; Dai, YS; Lee, JH; Lee, PL; Lin, MH; Lin, YT; Sun, C; Wan, KS; Wang, LC; Yang, YH; Yu, HH, 2016)
"Atopic dermatitis is a chronic, pruritic inflammatory disease that often disrupts sleep in severely affected children, but there are limited studies to guide clinical management of these sleep problems."2.58Managing sleep disturbances in children with atopic dermatitis. ( Levoska, M; Patel, D; Shwayder, T, 2018)
"Oral melatonin supplement has been shown to improve dermatitis severity in children with AD, but the mechanism of the effect is unclear, and it is uncertain whether melatonin has a direct immunomodulatory effect on the dermatitis."1.72Topical Melatonin Exerts Immunomodulatory Effect and Improves Dermatitis Severity in a Mouse Model of Atopic Dermatitis. ( Chang, YS; Chiang, BL; Tang, CY; Tsai, CC; Yang, PY, 2022)
"Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis."1.48Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018)
"Atopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease."1.46Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models. ( Kim, YU; Lee, SH; Oh, DS; Park, G, 2017)
"Melatonin is a hormone secreted from the pineal gland and is a potent antioxidant."1.43Evaluation of Oxidant-Antioxidant Balance in Children with Atopic Dermatitis: A Case-Control Study. ( Abas, Bİ; Avcil, S; Uysal, P; Yenisey, Ç, 2016)
"The newer and emerging treatments for atopic dermatitis (AD) focus on blockade of inflammatory cytokines, especially those that derive from T helper cell type 2 (TH2) and are associated with a pathway of immunoglobulin E (IgE) sensitization."1.43Assessing the New and Emerging Treatments for Atopic Dermatitis. ( Eichenfield, LF; Friedlander, SF; Irvine, AD; Simpson, EL, 2016)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's0 (0.00)18.2507
2000's4 (22.22)29.6817
2010's11 (61.11)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Chang, YS4
Tsai, CC1
Yang, PY1
Tang, CY1
Chiang, BL4
Bešlić, I1
Lugović-Mihić, L1
Vrtarić, A1
Bešlić, A1
Škrinjar, I1
Hanžek, M1
Crnković, D1
Artuković, M1
Park, G2
Lee, SH1
Oh, DS1
Kim, YU2
Patel, D1
Levoska, M1
Shwayder, T1
Taghavi Ardakani, A1
Farrehi, M1
Sharif, MR1
Ostadmohammadi, V1
Mirhosseini, N1
Kheirkhah, D1
Moosavi, SGA1
Behnejad, M1
Reiter, RJ2
Asemi, Z1
Jung, YS1
Park, MK1
Yang, CH1
Esmaeili, A1
Namazi, S1
Chou, YT1
Lee, JH2
Lee, PL2
Dai, YS2
Sun, C2
Lin, YT2
Wang, LC2
Yu, HH2
Yang, YH2
Chen, CA2
Wan, KS2
Marseglia, L1
D'Angelo, G1
Manti, S1
Salpietro, C1
Arrigo, T1
Barberi, I1
Gitto, E1
Lin, MH1
Chu, KH1
Uysal, P1
Avcil, S1
Abas, Bİ1
Yenisey, Ç1
Eichenfield, LF1
Friedlander, SF1
Simpson, EL1
Irvine, AD1
Kim, TH1
Jung, JA1
Kim, GD1
Jang, AH1
Ahn, HJ1
Park, YS1
Park, CS1
Kelsay, K1
Kimata, H1
Muñoz-Hoyos, A1
Espín-Quirantes, C1
Molina-Carballo, A1
Uberos, J1
Contreras-Chova, F1
Narbona-López, E1
Gutiérrez-Salmerón, MJ1
Schwarz, W1
Birau, N1
Hornstein, OP1
Heubeck, B1
Schönberger, A1
Meyer, C1
Gottschalk, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Melatonin for Adolescent Migraine Prevention Study (The MAP Study).[NCT03150797]Phase 272 participants (Actual)Interventional2017-08-02Terminated (stopped due to Insufficient Fund)
Effectiveness of Melatonin Supplement in the Management of Sleep Disturbances in Children With Atopic Dermatitis[NCT01638234]Phase 2/Phase 348 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Mean Migraine/Migrainous Days From Weeks 5-8 of Single-blind Treatment Phase to Weeks 5-8 of Randomized Treatment Phase for Each Group.

Change in mean migraine/migrainous days from weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase for each group. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg2
Melatonin 6mg-1
Placebo Oral Capsule0

Mean CASQ (Cleveland Adolescent Sleepiness Questionnaire) Score in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Mean CASQ score in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. The CASQ is a 16-question instrument that uses Likert-like responses and has a score range from 16-80; higher scores indicate greater sleepiness (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventionpoints (Mean)
Melatonin 3mg33
Melatonin 6mg36
Placebo Oral Capsule28

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 3 mg vs. Placebo.

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 3 mg vs. placebo. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg2
Melatonin 6mg2
Placebo Oral Capsule2

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 6 mg vs. Melatonin 3 mg.

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. melatonin 3 mg. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg2
Melatonin 6mg2
Placebo Oral Capsule2

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 6 mg vs. Placebo.

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. placebo. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg2
Melatonin 6mg2
Placebo Oral Capsule2

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Participants vs. Placebo.

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin treated participants vs. placebo. (Ultimately, as the data were not normally distributed, medians were more appropriate). (NCT03150797)
Timeframe: weeks 5-8 of randomized treatment phase

Interventiondays (Median)
Melatonin 3mg2
Melatonin 6mg2
Placebo Oral Capsule2

Number of Days Acute Medication is Used in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Number of days acute medication is used in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to the number of days that medication for the acute treatment of headache was used during the time frame. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg5
Melatonin 6mg3
Placebo Oral Capsule3

Number of Headache Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Number of headache days in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to number of headache days during the time period--regardless of whether they were migraine or not. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Interventiondays (Median)
Melatonin 3mg8
Melatonin 6mg4
Placebo Oral Capsule5

Reviews

5 reviews available for melatonin and Eczema, Atopic

ArticleYear
Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports.
    International journal of molecular sciences, 2023, Feb-17, Volume: 24, Issue:4

    Topics: Alopecia Areata; Antioxidants; Dermatitis, Atopic; Humans; Melatonin; Skin

2023
Managing sleep disturbances in children with atopic dermatitis.
    Pediatric dermatology, 2018, Volume: 35, Issue:4

    Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Benzodiazepines; Child; Cognitive Behavioral Thera

2018
Melatonin and atopy: role in atopic dermatitis and asthma.
    International journal of molecular sciences, 2014, Aug-04, Volume: 15, Issue:8

    Topics: Asthma; Dermatitis, Atopic; Humans; Immunoglobulin E; Immunomodulation; Interleukin-4; Melatonin

2014
Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin.
    International journal of molecular sciences, 2016, Mar-29, Volume: 17, Issue:4

    Topics: Child; Circadian Rhythm; Cytokines; Dermatitis, Atopic; Humans; Lymphocytes; Melatonin; Sleep Wake D

2016
Management of sleep disturbance associated with atopic dermatitis.
    The Journal of allergy and clinical immunology, 2006, Volume: 118, Issue:1

    Topics: Algorithms; Clonidine; Dermatitis, Atopic; Doxepin; Histamine H1 Antagonists; Humans; Hypnotics and

2006

Trials

3 trials available for melatonin and Eczema, Atopic

ArticleYear
The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2018, Volume: 29, Issue:8

    Topics: Child; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Immunoglobulin E; Iran; Male; Melato

2018
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
    JAMA pediatrics, 2016, Volume: 170, Issue:1

    Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud

2016
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
    JAMA pediatrics, 2016, Volume: 170, Issue:1

    Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud

2016
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
    JAMA pediatrics, 2016, Volume: 170, Issue:1

    Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud

2016
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
    JAMA pediatrics, 2016, Volume: 170, Issue:1

    Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud

2016
Elevation of salivary melatonin levels by viewing a humorous film in patients with atopic eczema.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2007, Volume: 39, Issue:4

    Topics: Adolescent; Amylases; Dermatitis, Atopic; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interfe

2007

Other Studies

10 other studies available for melatonin and Eczema, Atopic

ArticleYear
Topical Melatonin Exerts Immunomodulatory Effect and Improves Dermatitis Severity in a Mouse Model of Atopic Dermatitis.
    International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3

    Topics: Administration, Topical; Animals; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Model

2022
Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models.
    Journal of pineal research, 2017, Volume: 63, Issue:2

    Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Male; Melatonin; Mice; Neurons; Neurosecretory

2017
Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.
    Scientific reports, 2018, 10-08, Volume: 8, Issue:1

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Cell Line, Transformed; Dermatitis, A

2018
Is melatonin effective for pruritus caused by liver disease?
    Medical hypotheses, 2018, Volume: 121

    Topics: Animals; Cholestasis; Dermatitis, Atopic; Humans; Liver Diseases; Lysophospholipids; Melatonin; Mice

2018
Atopic dermatitis, melatonin, and sleep disturbance.
    Pediatrics, 2014, Volume: 134, Issue:2

    Topics: Actigraphy; Child; Child, Preschool; Comorbidity; Cross-Sectional Studies; Cytokines; Dermatitis, At

2014
Evaluation of Oxidant-Antioxidant Balance in Children with Atopic Dermatitis: A Case-Control Study.
    American journal of clinical dermatology, 2016, Volume: 17, Issue:5

    Topics: Adolescent; Antioxidants; Case-Control Studies; Child; Child, Preschool; Dermatitis, Atopic; Female;

2016
Assessing the New and Emerging Treatments for Atopic Dermatitis.
    Seminars in cutaneous medicine and surgery, 2016, Volume: 35, Issue:5 Suppl

    Topics: Child; Dermatitis, Atopic; Dietary Supplements; Humans; Interleukin-4 Receptor alpha Subunit; Interl

2016
Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.
    Journal of pineal research, 2009, Volume: 47, Issue:4

    Topics: Animals; Antioxidants; Dermatitis, Atopic; Dinitrofluorobenzene; Male; Melatonin; Mice; Skin Disease

2009
Neuroendocrine and circadian aspects (melatonin and beta-endorphin) of atopic dermatitis in the child.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2007, Volume: 18, Issue:8

    Topics: Adolescent; Adult; Aged; beta-Endorphin; Child; Child, Preschool; Circadian Rhythm; Dermatitis, Atop

2007
Alterations of melatonin secretion in atopic eczema.
    Acta dermato-venereologica, 1988, Volume: 68, Issue:3

    Topics: Adolescent; Adult; Circadian Rhythm; Dermatitis, Atopic; Female; Humans; Male; Melatonin; Pineal Gla

1988