melatonin and Dyskinesia, Drug-Induced studies

Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)

Research Excerpts

Excerpt	Relevance	Reference
" Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin."	7.68	Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990)
" On the basis of recent studies showing some benefit of antioxidants, we evaluated the effect of melatonin, the most potent naturally occurring antioxidant, on tardive dyskinesia in patients with chronic schizophrenia."	5.09	Is melatonin treatment effective for tardive dyskinesia? ( Barak, Y; Elizur, A; Plopsky, I; Shamir, E; Weizman, A; Zisapel, N, 2000)
"Using a double-blind, placebo-controlled, crossover study, we evaluated the efficacy of 10 mg/d of melatonin for 6 weeks in 22 patients with schizophrenia and TD."	5.09	Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. ( Barak, Y; Elizur, A; Laudon, M; Shalman, I; Shamir, E; Tarrasch, R; Weizman, R; Zisapel, N, 2001)
" Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin."	3.68	Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990)
" These results are consistent with previous work highlighting the importance of aberrant amine production in neurological disease and demonstrate that treatments that reduce endogenous melatonin bioavailability can ameliorate experimental PD."	1.30	A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease. ( Armstrong, SM; Willis, GL, 1999)

Research

Studies (26)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Abdominal Fat (DEXA).

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (23.08)	18.7374
1990's	11 (42.31)	18.2507
2000's	9 (34.62)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Bhakta, SG	1
Andrade, C	1
Naidu, PS	2
Singh, A	1
Kaur, P	1
Sandhir, R	1
Kulkarni, SK	2
Giladi, N	1
Shabtai, H	1
Willis, GL	1
Armstrong, SM	1
Shamir, E	2
Barak, Y	2
Plopsky, I	1
Zisapel, N	3
Elizur, A	2
Weizman, A	1
Raghavendra, V	1
Shalman, I	1
Laudon, M	1
Tarrasch, R	1
Weizman, R	1
Glazer, WM	1
Woods, SW	1
Goff, D	1
Abílio, VC	1
Vera, JA	1
Ferreira, LS	1
Duarte, CR	1
Carvalho, RC	1
Grassl, C	1
Martins, CR	1
Torres-Leite, D	1
Bignotto, M	1
Tufik, S	1
Ribeiro, Rde A	1
Frussa-Filho, R	1
Sandyk, R	15
Anninos, PA	1
Tsagas, N	1
Derpapas, K	1
Kay, SR	3
Pardeshi, R	1
Fisher, H	3

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]	Phase 4	25 participants (Actual)	Interventional	2008-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Intervention	g (Mean)
Ramelteon	3934.86
Placebo (Sugar Pill)	5120.92

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Waist Circumference

Intervention	HOMA score (Mean)
Ramelteon	2.4
Placebo (Sugar Pill)	2.36

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Article	Year
Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting. Cellular and molecular neurobiology, 2001, Volume: 21, Issue:6 Topics: Animals; Biological Clocks; Circadian Rhythm; Dopamine; Dyskinesia, Drug-Induced; Humans; Hypothalam	2001
The relationship of pineal calcification and melatonin secretion to the pathophysiology of tardive dyskinesia and Tourette's syndrome. The International journal of neuroscience, 1991, Volume: 58, Issue:3-4 Topics: Adult; Aged; Bipolar Disorder; Calcinosis; Dyskinesia, Drug-Induced; Female; Humans; Male; Melatonin	1991
Pineal melatonin in schizophrenia: a review and hypothesis. Schizophrenia bulletin, 1990, Volume: 16, Issue:4 Topics: Dyskinesia, Drug-Induced; Humans; Melatonin; Pineal Gland; Risk Factors; Schizophrenia; Schizophreni	1990
Tardive dyskinesia in bipolar disorders: possible role of pineal melatonin. The International journal of neuroscience, 1990, Volume: 52, Issue:3-4 Topics: Bipolar Disorder; Dyskinesia, Drug-Induced; Humans; Melatonin; Pineal Gland	1990
Melatonin, and opioid peptide interactions in tardive dyskinesia. The International journal of neuroscience, 1989, Volume: 48, Issue:3-4 Topics: Dyskinesia, Drug-Induced; Endorphins; Humans; Melatonin	1989
Tardive dyskinesia and the pineal gland. The International journal of neuroscience, 1988, Volume: 43, Issue:1-2 Topics: Dyskinesia, Drug-Induced; Humans; Melatonin; Pineal Gland	1988

Article	Year
Melatonin-controlled release - neurim pharmaceuticals. Circadin, melatonin-prolonged release, melatonin-sustained release. Drugs in R&D, 2003, Volume: 4, Issue:2 Topics: Administration, Oral; Age Factors; Delayed-Action Preparations; Drugs, Investigational; Dyskinesia,	2003
Is melatonin treatment effective for tardive dyskinesia? The Journal of clinical psychiatry, 2000, Volume: 61, Issue:8 Topics: Aged; Antioxidants; Antipsychotic Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Doub	2000
Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Archives of general psychiatry, 2001, Volume: 58, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Antipsychotic Agents; Chronic Disease; Corpus Striatum	2001
The relationship of pineal calcification and melatonin secretion to the pathophysiology of tardive dyskinesia and Tourette's syndrome. The International journal of neuroscience, 1991, Volume: 58, Issue:3-4 Topics: Adult; Aged; Bipolar Disorder; Calcinosis; Dyskinesia, Drug-Induced; Female; Humans; Male; Melatonin	1991

Article	Year
Melatonin treatment of shoulder-and-neck dyskinesia possibly related to fluoxetine treatment. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 3 Topics: Antioxidants; Dyskinesia, Drug-Induced; Fluoxetine; Humans; Male; Melatonin; Neck; Selective Seroton	2009
Possible mechanism of action in melatonin attenuation of haloperidol-induced orofacial dyskinesia. Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Free Radicals; Haloperidol; Lip	2003
Melatonin-induced withdrawal emergent dyskinesia and akathisia. Movement disorders : official journal of the Movement Disorder Society, 1999, Volume: 14, Issue:2 Topics: Adult; Akathisia, Drug-Induced; Dyskinesia, Drug-Induced; Female; Humans; Hypnotics and Sedatives; M	1999
A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease. Physiology & behavior, 1999, Volume: 66, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Availability; Body Weight; Circadi	1999
Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors. Brain research, 2001, Jun-15, Volume: 904, Issue:1 Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Dose-Res	2001
Should Sisyphus have taken melatonin? Archives of general psychiatry, 2001, Volume: 58, Issue:11 Topics: Antioxidants; Dyskinesia, Drug-Induced; Humans; Melatonin; Vitamin E	2001
Effects of melatonin on orofacial movements in rats. Psychopharmacology, 2002, Volume: 161, Issue:4 Topics: Age Factors; Animals; Corpus Striatum; Dyskinesia, Drug-Induced; Lighting; Lipid Peroxidation; Male;	2002
Accelerated growth of malignant melanoma by levodopa in Parkinson's disease and role of the pineal gland. The International journal of neuroscience, 1992, Volume: 63, Issue:1-2 Topics: Combined Modality Therapy; Corpus Striatum; Dyskinesia, Drug-Induced; Electric Stimulation; Equipmen	1992
Magnetic fields in the treatment of Parkinson's disease. The International journal of neuroscience, 1992, Volume: 63, Issue:1-2 Topics: Combined Modality Therapy; Corpus Striatum; Dyskinesia, Drug-Induced; Electric Stimulation; Equipmen	1992
Paraventricular nucleus-pineal interaction: relevance to tardive dyskinesia. The International journal of neuroscience, 1992, Volume: 62, Issue:3-4 Topics: Animals; Antipsychotic Agents; Brain; Brain Diseases; Dyskinesia, Drug-Induced; Female; Humans; Male	1992
The relationship of pineal calcification to tardive dyskinesia. The International journal of neuroscience, 1990, Volume: 52, Issue:1-2 Topics: Adult; Antipsychotic Agents; Brain Diseases; Calcinosis; Dyskinesia, Drug-Induced; Female; Humans; M	1990
Tardive dyskinesia associated with depression in a bipolar patient: possible role of melatonin. The International journal of neuroscience, 1990, Volume: 52, Issue:1-2 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Depression; Dyskinesia, Drug-Induced; Humans; Male; M	1990
Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. The International journal of neuroscience, 1990, Volume: 50, Issue:3-4 Topics: Adult; Depression; Dyskinesia, Drug-Induced; Female; Humans; Melatonin; Psoriasis; Psychotic Disorde	1990
The relationship of serotonin metabolism and melatonin secretion to the pathophysiology of tardive dyskinesia. The International journal of neuroscience, 1989, Volume: 48, Issue:1-2 Topics: Animals; Depression; Dyskinesia, Drug-Induced; Humans; Melatonin; Risk Factors; Serotonin	1989
Melatonin mediates the antidyskinetic effects of naloxone in tardive dyskinesia. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:2 Topics: Animals; Dyskinesia, Drug-Induced; Male; Melatonin; Naloxone; Rats; Rats, Inbred Strains	1989
Dexamethasone suppression test nonsuppression and tardive dyskinesia. Acta psychiatrica Scandinavica, 1989, Volume: 80, Issue:1 Topics: Dexamethasone; Dyskinesia, Drug-Induced; Humans; Hypothalamo-Hypophyseal System; Melatonin; Pituitar	1989
The protective function of the pineal gland in tardive dyskinesia. The International journal of neuroscience, 1988, Volume: 43, Issue:3-4 Topics: Animals; Dyskinesia, Drug-Induced; Humans; Melatonin; Pineal Gland	1988

melatonin and Dyskinesia, Drug-Induced