melatonin has been researched along with Disease Models, Animal in 885 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks." | 9.41 | The Effect of Melatonin on Periodontitis. ( Bábíčková, J; Baňasová, L; Celec, P; Chobodová, P; Janko, J; Konečná, B; Tóthová, Ľ, 2021) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 9.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "This review summarizes the numerous reports that have documented the neuroprotective actions of melatonin in experimental models of ischemia/reperfusion injury (stroke)." | 8.82 | Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. ( Lopez-Burillo, S; Manchester, LC; Mayo, JC; Reiter, RJ; Sainz, RM; Tan, DX, 2003) |
| "Melatonin is a candidate neuroprotective drug for ischaemic stroke." | 8.82 | Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. ( Donnan, GA; Horky, LL; Howells, DW; Macleod, MR; O'Collins, T, 2005) |
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 8.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "Conflicting results on melatonin synthesis in multiple sclerosis (MS) have been reported due to variabilities in patient lifestyles, which are not considered when supplementing melatonin." | 8.31 | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis. ( Ghareghani, M; Laflamme, N; Pons, V; Rivest, S; Zibara, K, 2023) |
| "The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 8.12 | Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022) |
| "To investigate the influence of melatonin on behavioral and neurological function of rats with focal cerebral ischemia-reperfusion injury via the JNK/FoxO3a/Bim pathway." | 8.12 | Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway. ( Chen, X; Deng, Y; Lai, J; Ou, Y; Peng, X; Shen, X; Wu, H; Wu, L; Yao, Z; Zhu, H, 2022) |
| " Inducing colitis by dextran sodium sulfate (DSS), HA-MT accumulated in the inflamed colon epithelium of colitis mice, and markedly improved the colitis symptoms, repaired the damaged intestinal barrier and inhibited colon inflammation." | 8.12 | Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis. ( Dong, S; Jing, W; Liu, W; Wang, F; Wang, K; Wang, S; Xu, Y; Yang, J; Zhao, X; Zhu, M, 2022) |
| "Reduced levels of retinal dopamine, a key regulator of eye development, are associated with experimental myopia in various species, but are not seen in the myopic eyes of C57BL/6 mice, which are deficient in melatonin, a neurohormone having extensive interactions with dopamine." | 8.12 | Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia. ( Chen, WH; Cui, LJ; Gong, X; Huang, F; Li, YY; Liu, AL; Liu, YF; Ma, YY; Qian, KW; Qu, J; Wang, Q; Weng, SJ; Wu, XH; Yang, XL; Yang, Z; Yu, CX; Zhong, YM; Zhou, X, 2022) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 8.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| " Melatonin treatment suppresses ferroptosis and alleviates kidney injury in the context of experimental sepsis by upregulating Nrf2/HO-1 pathway." | 8.12 | Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. ( An, S; Chen, Z; Gao, Y; Li, J; Lin, B; Lin, X; Qiu, W; Wang, T; Yu, B; Zeng, Z, 2022) |
| "Melatonin (MT), a neurohormone with immunomodulatory properties, is one of the metabolites produced in the brain from tryptophan (TRP) that has already strong links with the neuropathogenesis of Multiple sclerosis (MS)." | 8.12 | Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway. ( Ejtemaei-Mehr, S; Ghahremani, MH; Ghanbari, A; Ghazi-Khansari, M; Guillemin, GJ; Jand, Y, 2022) |
| "Melatonin is a potent neuroprotective agent which has shown therapeutic effects in animal models of brain injury such as stroke." | 8.12 | Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke. ( Cambiaghi, M; Cherchi, L; Comai, S, 2022) |
| "Melatonin (MLT) was reported to have therapeutic effects on inflammatory bowel disease (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) due to its anti-inflammatory and immunomodulatory properties." | 8.12 | RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. ( Deng, Y; Fei, S; Feng, S; Li, L; Mo, Y; Song, J; Wang, K; Wu, J; Xu, Z; Zhang, Q; Zhang, Z; Zhou, R, 2022) |
| "Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin." | 8.02 | Melatonin improves periodontitis-induced kidney damage by decreasing inflammatory stress and apoptosis in rats. ( Akyildiz, K; Altin, A; Arabaci, T; Bostan, SA; Emre Kose, T; Kose, O; Kuluslu, G; Kurt Bayrakdar, S; Mercantepe, T; Tumkaya, L; Turker Sener, L; Unver, B; Yilmaz, A, 2021) |
| "This study aimed to investigate the protective effect of melatonin on the corneal epithelium in dry eye disease(DED) and explore its underlying mechanism." | 8.02 | Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye. ( Li, S; Ouyang, H; Peng, L; Wang, B; Wang, L; Wang, X; Xiao, Y; Yuan, J; Zeng, H; Zhong, J; Zuo, X, 2021) |
| " Melatonin is involved in the outcome of normal pregnancy." | 8.02 | Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia. ( Aref, M; El-Malkey, NF; Emam, H; Khalil, SS, 2021) |
| "Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1-7)." | 8.02 | Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction. ( An, S; Chen, Z; Fang, H; Han, Y; Huang, Q; Li, L; Wu, J; Xu, S; Zeng, Z, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 8.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| "Over the past few years, ozone has been identified as a potential risk factor for exacerbating asthma." | 8.02 | Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway. ( Chen, Y; Li, J; Liu, X; Wu, X; Yang, X; Zeng, Y, 2021) |
| " Our previous studies found that melatonin exerts an improvement effect in sleep deprivation (SD)- induced corticosterone overproduction and colitis." | 8.02 | Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2021) |
| "The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS." | 8.02 | Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model. ( Chen, J; Chen, XG; Du, HX; Liang, CZ; Liu, Y; Wen, LP; Zhan, CS; Zhang, L; Zhang, LG; Zhang, M, 2021) |
| " This study investigated the potential effects of luzindole on LPS/d-galactosamine (d-GalN)-induced acute hepatitis." | 7.96 | Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. ( Huang, J; Li, L; Luo, Y; Shen, Y; Tang, L; Yang, Y; Zhang, L, 2020) |
| "The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model." | 7.96 | Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants. ( Akbulut, HF; Sekmenli, T; Vatansev, H, 2020) |
| "This study sought to investigate a novel effect of melatonin in reducing brain injury in an in vivo hyperglycemic intracerebral hemorrhage (ICH) model and further explore the mechanisms of protection." | 7.96 | Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats. ( Liang, F; Shi, L; Sun, Z; Wang, J; Wang, Z; Xu, S; Zhang, J; Zheng, J; Zhou, J; Zhu, X, 2020) |
| "Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism has not been identified." | 7.96 | Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury. ( Cui, JW; Ma, X; Wei, LL; Yang, B; Zang, LE; Zhang, MY, 2020) |
| "An emerging area in schizophrenia research focuses on the impact of immunomodulatory drugs such as melatonin, which have played important roles in many biological systems and functions, and appears to be promising." | 7.96 | Schizophrenia-like behavior is not altered by melatonin supplementation in rodents. ( Afonso, AC; Bialecki, AVS; Bischoff, LM; Canever, L; Godoi, AK; Hubbe, I; Mastella, GA; Pacheco, FD; Wessler, PG; Zugno, AI, 2020) |
| "Melatonin (N‑acetyl‑5‑methoxytryptamine; MT) has been shown to have a protective effect against sepsis‑induced renal injury, however, the mechanisms underlying the function of MT remain to be elucidated." | 7.91 | Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway. ( Dai, W; Deng, Y; Hu, S; Huang, H; Si, L; Xu, L; Zhou, L, 2019) |
| " Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model." | 7.91 | Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model. ( Cui, K; Liu, J; Ruan, Y; Song, J; Tang, Z; Wang, S; Wang, T; Yang, J; Yu, Z, 2019) |
| "Melatonin is a neurohormone that is linked to the pathogenesis of schizophrenia." | 7.91 | Reversal of Schizophrenia-like Symptoms and Cholinergic Alterations by Melatonin. ( Akram, M; Andrabi, SS; Kaushik, M; Parveen, K; Parvez, S; Tabassum, H; Vishnoi, S, 2019) |
| "A high-fat diet (FD)-induced obesity mouse model was subjected to intermittent hypoxia/normoxia events for approximately 8 h per day using an autophagy agonist, rapamycin, or an inhibitor, 3-methyladenine (3-MA), and SRT1720, a sirtuin 1 (SIRT1) activator, or sirtinol, a SIRT1 inhibitor, with or without melatonin for a total of six successive weeks, followed by assessment of expression of autophagy-related genes and activity of serum aminotransferase as well as histological evaluation of tissue morphology." | 7.91 | Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. ( Han, Y; Jin, M; Li, GC; Liu, HG; Luo, M; Ren, J; You, ZX, 2019) |
| "Despite melatonin treatment diminishes inflammatory mediator production and improves organ injury after acute pancreatitis (AP), the mechanisms remain unknown." | 7.91 | Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway. ( Chen, TH; Cheng, HT; Chiang, KC; Hsu, JT; Kuo, CJ; Le, PH; Lin, CJ; Wu, RC, 2019) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 7.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| " Emerging evidence suggests pleiotropic roles of melatonin in cardiac disease; however, the effects of melatonin on physiological vs pathological cardiac hypertrophy remain unknown." | 7.91 | Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. ( Gao, L; Gao, Y; Ji, Q; Lan, F; Pu, J; Sheng, X; Su, Y; Tong, R; Wu, F; Xu, L; Yan, Y; Ying, X; Yuan, A; Zhao, Y, 2019) |
| "Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury." | 7.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| "To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL)." | 7.91 | Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome. ( Bosco, AD; Colares, JR; Dias, AS; Forgiarini Junior, LA; Hartmann, RM; Marroni, NP; Schedler, FB; Schemitt, EG, 2019) |
| " The aim of the present study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of antibiotics and/or melatonin treatments on diet-induced hepato-intestinal dysfunction and inflammation." | 7.91 | The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats. ( Akdeniz, E; Aksu, B; Arabacı Tamer, S; Bagriacik, F; Cayirli, YB; Çetinel, Ş; Cilingir Kaya, ÖT; Kahraman, MM; Onur, ND; Sahin, D; Yeğen, BÇ; Yildirim, A; Yuksel, M, 2019) |
| "To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis." | 7.88 | Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018) |
| "This study demonstrated that melatonin pretreatment attenuated lung ischaemia-reperfusion injury via inhibition of oxidative stress, inflammation and apoptosis." | 7.88 | Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. ( Wang, JJ; Wang, JS; Wang, ML; Wang, WD; Wei, CH; Zhang, J, 2018) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 7.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| " Aim The present study aims to examine the effect of melatonin supplementation and pinealectomy on leptin, neuropeptide Y (NPY), melatonin and zinc levels in rats with hypothyroidism and hyperthyroidism." | 7.88 | Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland. ( Baltaci, AK; Mogulkoc, R, 2018) |
| " We now assessed lymphatic Aβ clearance by treating a mouse model of AD amyloidosis with melatonin, an Aβ aggregation inhibitor and immuno-regulatory neurohormone." | 7.88 | Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis. ( Matsubara, E; Pacheco-Quinto, J; Pappolla, MA; Poeggeler, B; Sambamurti, K; Vidal, R; Zagorski, M, 2018) |
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 7.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models." | 7.88 | Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. ( Beilman, GJ; Mulier, KE; Suryanarayanan, R; Thakral, S; Wolf, A, 2018) |
| "Melatonin has been shown to inhibit myocardial infarction-induced apoptosis, its function in heart failure with preserved ejection fraction (HFpEF) has not been investigated." | 7.88 | Melatonin improves cardiac function in a mouse model of heart failure with preserved ejection fraction. ( Dong, JZ; Gao, L; Guo, S; Li, L; Li, LN; Liang, C; Liu, Y; Liu, YZ; Tu, S; Wang, D; Yang, HB; Zhao, XY, 2018) |
| "The application of the melatonin antagonist of Luzindole can improve the success rate of the bipedal rat scoliosis model." | 7.85 | The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model. ( Jiang, J; Jin, X; Lu, F; Ma, X; Xia, X; Yang, S; Zheng, C; Zhu, W, 2017) |
| "Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice." | 7.85 | Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. ( Beker, MC; Caglayan, AB; Caglayan, B; Gunal, MY; Gundogdu, RZ; Kelestemur, T; Kerman, BE; Kilic, E; Kilic, U; Yalcin, E; Yılmaz, B; Yulug, B, 2017) |
| " The aim of this study is to investigate whether iron overload causes the apoptosis and necrosis of bone marrow mesenchymal stem cells (BMSCs) and melatonin may prevent its toxicity." | 7.85 | Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin. ( Bao, Z; Cai, B; Ding, F; Du, Z; Feng, C; Gong, R; Han, Z; Hua, B; Huang, Q; Idiiatullina, E; Li, Y; Liu, T; Ma, W; Pavlov, V; Wang, X; Yan, G; Yang, F; Yang, L; Yu, Y; Yuan, Y; Zhang, L, 2017) |
| "Melatonin is a neurohormone that is linked to the aetiopathogenesis of schizophrenia." | 7.85 | Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia. ( Aina, OA; Onaolapo, AY; Onaolapo, OJ, 2017) |
| "The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM)." | 7.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol." | 7.85 | Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. ( Chen, X; Duan, W; Jin, Z; Jing, L; Li, B; Li, K; Liang, H; Liu, J; Liu, Z; Reiter, RJ; Ren, K; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, B; Yu, S; Zhai, M; Zhang, B; Zhang, M, 2017) |
| "Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome." | 7.85 | Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Diego, M; García-Cerro, S; Lantigua, S; Martínez-Cué, C; Parisotto, EB; Rueda, N; Sanchez-Barceló, EJ; Vidal, V; Wilhem Filho, D, 2017) |
| "Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury." | 7.85 | Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017) |
| " This study explored the hypothesis that melatonin has beneficial functions in the mouse model of colitis induced by dextran sodium sulfate (DSS), with a specific focus on the expression of intestinal inflammatory cytokines and the serum levels of amino acids." | 7.85 | Melatonin alters amino acid metabolism and inflammatory responses in colitis mice. ( Chen, S; Fang, J; Jiang, Q; Liu, G; Ren, W; Yao, K; Yin, J; Yin, Y, 2017) |
| "Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models." | 7.85 | D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study. ( Beilman, GJ; Mulier, KE; Muratore, SL; Wolf, A, 2017) |
| "The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis." | 7.85 | Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis. ( Albayrak, M; Arabaci, T; Erdemci, B; Gedikli, S; Kara, A; Kermen, E; Kizildag, A; Köse, O; Özkal Eminoğlu, D; Özkanlar, S; Zihni, M, 2017) |
| "To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma." | 7.85 | Elevated intraocular pressure increases melatonin levels in the aqueous humour. ( Alkozi, H; Carracedo, G; de Lara, MJ; Fonseca, B; Martinez-Aguila, A; Pintor, J; Sánchez-Naves, J, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 7.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| "The present study was aimed at evaluating the rapidity and duration of melatonin as an antidepressant in a rat model of depression." | 7.85 | Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress. ( Li, Q; Lian, B; Sun, H; Sun, L; Sun, X; Wang, G; Wang, M; Wang, Y, 2017) |
| "The influence of melatonin on the reduced glutathione content, activity of glutathione peroxidase, glutathione reductase, and glutathione transferase in blood serum, heart, liver, and skeletal muscle of rats under conditions of experimental rheumatoid arthritis development has been estimated." | 7.83 | [EFFECT OF MELATONIN ON THE GLUTATHIONE ANTIOXIDANT SYSTEM ACTIVITY IN RAT TISSUES UNDER CONDITIONS OF EXPERIMENTAL RHEUMATOID ARTHRITIS.] ( Makeeva, AV; Popova, TN; Safonova, OA; Synorova, AA, 2016) |
| "Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function." | 7.83 | Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016) |
| "Melatonin was effective in the treatment of experimental endometriosis induced in SCID mice." | 7.83 | The effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in the first SCID-mouse endometriosis-model developed in Turkey. ( Akkaya, H; Attar, R; Ozkan, F; Yesildaglar, N; Yildirim, G; Yildirim, OK; Yilmaz, B, 2016) |
| "Previous studies have demonstrated that melatonin administration improves spatial learning and memory and hippocampal long-term potentiation in the adult Ts65Dn (TS) mouse, a model of Down syndrome (DS)." | 7.83 | Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome. ( García-Cerro, S; Lantigua, S; Martínez-Cué, C; Parisotto, EB; Rueda, N; Sanchez-Barceló, EJ; Vidal, V; Wilhelm Filho, D, 2016) |
| "Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS)." | 7.83 | Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis. ( Ariyannur, PS; Kirmani, BF; Moffett, JR; Namboodiri, AM; Ribeiro, R; Tanaka, M; Wen, J; Zhang, Y, 2016) |
| "The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus." | 7.83 | Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus. ( Arkhipov, SA; Ishchenko, IY; Klimontov, VV; Konenkov, VI; Michurina, SV; Rachkovskaya, LN; Zavyalov, EL, 2016) |
| "To explore the effects of Kaixin Powder (, KXP) on melatonin receptor (MR) expression and (125)I-Mel binding affinity in a depression rat model." | 7.81 | Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. ( Cai, C; Gao, C; Guan, JH; Guo, J; Huang, YL; Liang, XB; Qian, LQ; Zhao, GP, 2015) |
| "Melatonin (MLT) is an endogenous indole compound with numerous biological activities that has been associated with atherosclerosis (AS)." | 7.81 | Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits. ( Cheng, X; Wan, Y; Wang, Y; Xu, Y; Zhou, Q; Zhu, H, 2015) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 7.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| " Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized." | 7.81 | Melatonin improves experimental colitis with sleep deprivation. ( Baik, HW; Chung, SH; Kim, DS; Kim, JB; Kim, JH; Kim, TK; Lee, SK; Park, YS, 2015) |
| "The aim of this study was to determine the effects of some polyunsaturated fatty acids plus phytomelatonin from walnuts in the development of mammary gland adenocarcinoma." | 7.81 | Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model. ( Berra, MA; Comba, A; Das, UN; Eynard, AR; Garcia, CP; Labuckas, DO; Lamarque, AL; Pasqualini, ME; Silva, RA, 2015) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 7.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 7.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 7.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| "Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects." | 7.80 | Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis. ( Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M, 2014) |
| "Resveratrol/melatonin combination effectively normalizes anthropometrical, biochemical, and histopathological parameters in ovariectomized rats with fructose diet-induced obesity and associated metabolic alterations." | 7.80 | Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats. ( Giri, PR; Majumdar, AS; Pai, SA, 2014) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 7.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "The present study aimed to evaluate the therapeutic effects of melatonin on either ghrelin secretion or gastric mucosal injury in acute necrotizing pancreatitis (ANP)." | 7.80 | Melatonin reduces inflammation and recovers endogenous ghrelin in acute necrotizing pancreatitis in rats. ( Huang, JA; Liang, ZH; Qin, MB; Su, J; Tang, GD; Yang, HY, 2014) |
| "Aluminum (Al) is a known neurotoxic element involved in the etiology of some serious neurodegenerative disorders such as Alzheimer disease (AD)." | 7.80 | Chronic exposure to aluminum and melatonin through the diet: neurobehavioral effects in a transgenic mouse model of Alzheimer disease. ( Colomina, MT; Di Paolo, C; Domingo, JL; Gómez, M; Reverte, I, 2014) |
| "The aim of the work was investigation of both humoral and cell-mediated immunity together with leukocytes functional stability indexes in rats with the experimental contact dermatitis (ECD) in conditions of complex pharmacological correction using deltaran and melatonin." | 7.80 | [Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis]. ( Shandra, OO, 2014) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 7.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "These results indicate that treatment with melatonin, starting after the onset of uveitis, attenuated ocular inflammation induced by LPS in the Syrian hamster and support the use of melatonin as a therapeutic resource for uveitis treatment." | 7.80 | Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation. ( Chianelli, M; Domínguez Rubio, AP; Dorfman, D; Fernandez, DC; Franchi, AM; Rosenstein, RE; Sáenz, DA; Sande, PH; Silberman, DM, 2014) |
| "The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi." | 7.80 | Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. ( Kireev, RA; Tresguerres, JA; Vara, E; Viña, J, 2014) |
| "This study was undertaken to study the effects of melatonin on metabolic and reproductive aspects of polycystic ovary syndrome (PCOS) in rats." | 7.80 | Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. ( Majumdar, AS; Pai, SA, 2014) |
| "The aim of the study was to examine the reorganization of extracellular matrix left ventricular myocardium (LVM) rats (n = 38) with experimental heart failure (EHF) as affected by perindopril and melatonin administration." | 7.80 | [Extracellular matrix remodeling myocardium of the left ventricle rats with experimental heart failure after perindopril and melatonin administration]. ( Liskova, IuV; Salikova, SP; Stadnikov, AA, 2014) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 7.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Decline with age of the content of melatonin is considered as one of the leading mechanisms of aging and development of associated diseases, including age-related macular degeneration (AMD)--the disease, which becomes the most common cause of blindness and acuity of vision deterioration in elderly." | 7.79 | [Potential of melatonin for prevention of age-related macular degeneration: experimental study]. ( Fursova, AZh; Kolosova, NG; Stefanova, NA; Zhdankina, AA, 2013) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 7.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| " This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti-inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)-induced colitis in pinealectomized (Px) rats." | 7.79 | Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis. ( Acet, A; Kaya, E; Parlakpinar, H; Tasdemir, S; Vardi, N, 2013) |
| "The vasopressin and oxytocin content of the hypothalamus and neurohypophysis, as well as their plasma levels, were radioimmunoassayed in sham-operated or pinealectomized rats with left coronary artery ligation (CAL)-evoked myocardial infarction as well as under melatonin treatment." | 7.78 | Function of the hypothalamo-neurohypophysial system in rats with myocardial infarction is modified by melatonin. ( Ciosek, J; Drobnik, J, 2012) |
| "Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms." | 7.78 | Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. ( Chen, G; He, WC; Huo, L; Liu, HX; Ma, C; Meng, CJ; Shen, XM; Shu, Z; Sun, XB; Wang, Z; Zhang, J; Zhu, GQ, 2012) |
| "To compare the efficacy of ozone with melatonin, shown as the most powerful antioxidant in attenuation of testicular ischemia/reperfusion injury, in an experimental rat model of testicular torsion/detorsion." | 7.78 | Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats. ( Benli Aksungar, F; Doğan Ekici, AI; Ekici, S; Lüleci, N; Öztürk, G; Sinanoğlu, O; Turan, G, 2012) |
| "To study the effect of Kaixin San on the rate-limiting enzyme in biosynthesis of melatonin (MT) and pineal body in rat depression model." | 7.78 | [Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model]. ( Cai, C; Liang, X; Peng, X; Qian, G; Zhao, G, 2012) |
| "In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated." | 7.77 | The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011) |
| "The efficacy of melatonin treatment in experimental stroke has been established." | 7.77 | Melatonin treatment following stroke induction modulates L-arginine metabolism. ( Appleton, I; Clarkson, AN; Nair, SM; Rahman, RM; Sammut, IA; Sutherland, BA; Taurin, S, 2011) |
| "In this study, the effects of melatonin or beta-glucan treatments on tumor growth, pro-oxidant, and antioxidant status in tumor tissue were investigated in Dunning 3327 MatLyLu prostatic adenocarcinoma model." | 7.77 | Melatonin and beta-glucan alone or in combination inhibit the growth of dunning prostatic adenocarcinoma. ( Balkan, J; Doğru-Abbasoğlu, S; Kabasakal, L; Keyer-Uysal, M; Sener, G; Uysal, M, 2011) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 7.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| "This experimental study was designed to produce ischemia-reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters." | 7.76 | An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. ( Akbas, A; Atılgan, D; Erdemir, F; Erkorkmaz, U; Parlaktas, BS; Uluocak, N; Yasar, A, 2010) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 7.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats." | 7.76 | Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. ( Ayer, R; Chen, W; Hartman, R; Lekic, T; Manaenko, A; Rojas, H; Tang, J; Zhang, JH, 2010) |
| "The present study was designed to evaluate whether the administration of s-methylisothiourea and melatonin has protective potential in intestinal ischemia/reperfusion injury." | 7.76 | Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats. ( Atabek, C; Demirin, H; Karaoglu, A; Kesik, V; Korkmaz, A; Kul, M; Ozler, M; Oztas, E; Sadir, S; Temiz, A; Tunc, T, 2010) |
| "The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes." | 7.76 | Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. ( Balaraman, R; Patel, V; Upaganlawar, A; Zalawadia, R, 2010) |
| "To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism." | 7.76 | [Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats]. ( Ding, CH; Dong, YJ; Gu, WW; Suo, XH, 2010) |
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 7.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "This study investigated the effect of aging-related parameters such as inflammation, oxidative stress and cell death in the heart in an animal model of accelerated senescence and analyzed the effects of chronic administration of melatonin on these markers." | 7.76 | Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. ( Acuña-Castroviejo, D; Cuesta, S; Forman, K; García, C; Kireev, R; Tresguerres, JA; Vara, E, 2010) |
| "To investigate the expression of melatonin MT1 receptor in rats with acute necrotizing pancreatitis (ANP) and the protective effects of melatonin (MT) pre-intervention for the pancreas." | 7.76 | [The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin]. ( Chen, LQ; Gao, DJ; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Zhai, K, 2010) |
| "The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis." | 7.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "To investigate the effect of melatonin on the colon inflammatory injury of rats with colitis and determine whether this effect is associated with inhibition of chemoattractant molecules interleukin (IL-8) and monocyte chemoattractant protein (MCP-1)." | 7.74 | Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. ( Li, HX; Li, JH; Liu, K; Wang, L; Zhou, W, 2008) |
| "This study tries to tests the hypothesis that "the intake of melatonin can minimize the morphological features of cell damage associated with radiation enteritis"." | 7.74 | Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model. ( Abdulwahed, SR; Abou El-Ghait, AT; Abu-Dief, EE; Ahmad, MH; Hussein, MR; Kamel, E, 2008) |
| " Since melatonin is a potent free radical scavenger and indirect antioxidant, the objective of this study was to evaluate whether melatonin administration would attenuate oxidative stress, brain edema, and neurological deficits in a rat model of ICH." | 7.74 | The antioxidant effects of melatonin after intracerebral hemorrhage in rats. ( Chen, W; Jadhav, V; Lekic, T; Martin, RD; Rojas, H; Tang, J; Titova, E; Zhang, J, 2008) |
| "The aim of this study was to compare the effects of mannitol and melatonin on brain edema secondary to trauma using magnetic resonance imaging (MRI)." | 7.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| "The aim of this study is to determine the effect of melatonin on intestinal anastomosis in the presence of peritonitis." | 7.74 | Effect of melatonin on healing of colonic anastomosis in a rat model of peritonitis. ( Başaklar, AC; Bukan, N; Demiroğullari, B; Ekingen, G; Kale, N; Karabulut, R; Ozen, IO; Sönmez, K; Taşlipinar, MY, 2007) |
| "To determine the antioxidant, antiinflammatory, and immunomodulatory effects of melatonin on endometrial explants, the distribution of cyclooxygenase-2 (COX-2), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and levels of malondialdehyde (MDA) in the rat endometriosis model." | 7.74 | Regression of endometrial explants in a rat model of endometriosis treated with melatonin. ( Güney, M; Karahan, N; Mungan, T; Oral, B, 2008) |
| "The study in ovariectomized (Ovx) rats, as a model of menopausal status, of the effects of melatonin (M) and/or estradiol (E), associated or not with food restriction, on body weight (BW) and serum leptin levels." | 7.74 | Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats. ( Alonso-Gonzalez, C; Cos, S; Gonzalez, A; Martinez-Campa, CM; Mediavilla, MD; Sanchez-Barcelo, EJ; Sanchez-Mateos, S, 2007) |
| " with normal saline in the control group (n = 21) and the asthma group (n = 22), melatonin in the melatonin group (n = 23), dexamethasone in the dexamethasone group (n = 24), and melatonin antagonist luzindole in the luzindole group (n = 7) respectively." | 7.74 | [The effect of melatonin on the regulation of collagen accumulation and matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 mRNA and protein in a murine model of chronic asthma]. ( Li, F; Liu, RY; Qian, ZX; Zhou, L, 2007) |
| " Compared with vehicle controls, melatonin therapy after hemorrhagic shock significantly improved plasma disappearance rate of indocyanine green, hepatic redox state, hepatocellular injury, and hepatic perfusion index." | 7.74 | Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Rensing, H; Waibel, L; Weiler, J; Wolf, B, 2008) |
| "Melatonin secretion decreased in fructose fed rats that developed hypertension." | 7.74 | The role of melatonin in the pathogenesis of hypertension in rats with metabolic syndrome. ( Grossman, E; Leibowitz, A; Peleg, E; Shabtai, Z; Shamiss, A; Sharabi, Y, 2008) |
| "Melatonin attenuates the short-term consequences of brain ischemia in several animal models." | 7.74 | Chronic and acute melatonin effects in gerbil global forebrain ischemia: long-term neural and behavioral outcome. ( de Butte, M; Fréchette, M; Pappas, BA; Rennie, K, 2008) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 7.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "The current study was undertaken to determine whether melatonin therapy reverses vasospasm and prevents apoptosis by inhibiting lipid peroxidation in an experimental subarachnoid hemorrhage (SAH) model." | 7.73 | Effect of melatonin on cerebral vasospasm following experimental subarachnoid hemorrhage. ( Altinors, N; Atalay, B; Aydin, MV; Caner, H; Cekinmez, M; Ozen, O; Sen, O, 2005) |
| "The aim of this study was to evaluate the effects of melatonin on the inflammatory response and hydroxyproline production in an experimental acute and chronic model of trinitrobenzene sulfonic (TNBS) acid-induced colitis in Wistar rats." | 7.73 | Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. ( Calvo, JR; la de Lastra, CA; Marquez, E; Motilva, V; Sánchez-Fidalgo, S, 2006) |
| "To investigate whether a protein kinase C (PKC) inhibitor and melatonin prevent proliferative vitreoretinopathy (PVR)." | 7.73 | Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin. ( Er, H; Mizrak, B; Parlakpinar, H; Turkoz, Y, 2006) |
| "To observe ultrastructural changes and leptin expression in the guinea pig eye during experimental uveitis (EU) and the effects of vitamin E, melatonin and aprotinin on leptin expression." | 7.73 | Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitis. ( Alagöz, G; Celebi, S; Colakoğlu, N; Kükner, A; Kükner, AS; Serin, D, 2006) |
| "To determine the effects of melatonin combined with antibiotic administration on the suppression of renal scarring in an experimental pyelonephritis model." | 7.73 | Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis. ( Bahat, E; Cay, A; Cobanoglu, U; Imamoğlu, M; Karahan, C; Sarihan, H; Tosun, I, 2006) |
| "The 2[125I]iodomelatonin binding assay was used to investigate the involvement of melatonin receptors in the development of scoliosis in pinealectomized chickens." | 7.73 | Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. ( Cheung, KM; Leong, JC; Lu, DS; Poon, AM, 2006) |
| "Various evidences have documented that the pineal secretory product melatonin exerts an important anti-inflammatory effect in different experimental models including colitis." | 7.73 | Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. ( Crisafulli, C; Cuzzocrea, S; Di Bella, P; Esposito, E; Mazzon, E; Meli, R; Muià, C; Riccardi, L, 2006) |
| "To evaluate effects of melatonin on sodium selenite-induced cataract formation." | 7.73 | Use of melatonin to prevent selenite-induced cataract formation in rat eyes. ( Aydin, B; Durmuş, M; Erdurmuş, M; Gürel, A; Karadağ, R; Yağci, R; Yiğitoğlu, R, 2006) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 7.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| " In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis." | 7.72 | Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004) |
| "The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 7.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
| "The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determine the effects of melatonin and methylprednisolone on this oxidative stress." | 7.72 | Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. ( Aktan, B; Akyuz, M; Altas, E; Buyukokuroglu, ME; Ozabacigil, F; Ucuncu, H, 2004) |
| "Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth and an increase when relapse occurred." | 7.70 | Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion. ( Bartsch, C; Bartsch, H; Besenthal, I; Buchberger, A; Effenberger-Klein, A; Kruse-Jarres, JD; Mecke, D; Rokos, H; Stieglitz, A, 1999) |
| " The current study was designed to investigate the protective effect of melatonin, a radical scavenger and antioxidant, on non-septic shock induced by zymosan in the rat." | 7.70 | Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan. ( Caputi, AP; Cuzzocrea, S; El-Sokkary, GH; Hassanein, AF; Reiter, RJ; Tan, DX, 1999) |
| " In communicating hydrocephalus, the function of the tela choroidae could be impaired by infectious or inflammatory processes; while in schizophrenia a physiologic disorder of cerebrospinal fluid production due to a melatonin deficiency may result in dilated ventricles." | 7.67 | The pathophysiology of enlarged ventricles in normal pressure communicating hydrocephalus and schizophrenia: a possible therapeutic role for melatonin. ( Maurizi, CP, 1987) |
| "Melatonin is a potent antioxidant and anti-inflammatory agent that is showing promising results in acute brain injury." | 6.72 | Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis. ( Chen, C; Hu, X; Hu, Z; Qin, H; Tang, J; Zeng, L; Zhu, Y, 2021) |
| "Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis." | 6.49 | Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. ( Chang, DM; Chen, SJ; Huang, SH; Lin, GJ; Sytwu, HK; Wang, CH, 2013) |
| "Obesity has become an epidemic in industrialized and developing countries." | 6.48 | Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. ( Korkmaz, A; Ma, S; Reiter, RJ; Tan, DX, 2012) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 6.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "Age-related macular degeneration is the leading cause of visual deficiency in older adults worldwide." | 5.91 | Melatonin protects retinal integrity through mediated immune homeostasis in the sodium iodate-induced mouse model of age-related macular degeneration. ( Cheng, HH; Ku, LC; Lai, DW; Lai, LC; Lee, CY; Lin, KH; Sheu, ML; Tsai, CY; Tsai, YC, 2023) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 5.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Melatonin is a neuroendocrine hormone mainly secreted by the pineal gland that plays an important role in the maintenance of the circadian rhythm and immunomodulation." | 5.72 | Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice. ( Cheng, B; Ding, Y; Liu, Y; Wei, M; Weng, X; Yu, S, 2022) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 5.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 5.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Melatonin treatment may have a therapeutic effect against sepsis since it prevents the increase in serum VEGF level." | 5.62 | Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis. ( Betül Tuncer, F; Boz, M; Çakıroğlu, H; Çokluk, E; Doğanay, S; Ramazan Şekeroğlu, M, 2021) |
| "Melatonin (5 mg/kg) was injected i." | 5.62 | Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis. ( Bodard, S; Chalon, S; Favrais, G; Gressens, P; Gulhan, Z; Saliba, E; Savary, L, 2021) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 5.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| "Melatonin (MT) is an indoleamine hormone that can counteract ischemia‑induced organ injury through its antioxidant effects." | 5.62 | Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway. ( Cai, QQ; Li, HW; Wu, XL; Yang, ZH; Ying, P, 2021) |
| "Melatonin treatment led to a significant reduction in the degree of breast hyperplasia (P<0." | 5.62 | Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway. ( Huang, Y; Niu, Y; Zhang, X, 2021) |
| "Melatonin is an antioxidant; however, its role in MTX neuropathy is not well studied." | 5.56 | Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. ( Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC, 2020) |
| "Melatonin is a pleiotrophic hormone, synthesised primarily by the pineal gland under the control of the suprachiasmatic nuclei (SCN)." | 5.56 | Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease? ( Bawden, CS; Kuchel, TR; Middleton, B; Morton, AJ; Rudiger, S; Skene, DJ, 2020) |
| "Melatonin has been demonstrated to ameliorate cardiac hypertrophy and its accompanied fibrosis in previous studies." | 5.56 | A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy. ( Cao, F; Lei, C; Liu, L; Wang, B; Wang, J; Wang, X; Yang, Q; Yuan, J; Zhang, J; Zhao, X; Zhu, X, 2020) |
| "Melatonin treatment also reduced sFlt-1, increased PlGF, and decreased the sFlt-1/PlGF ratio." | 5.56 | Melatonin attenuates hypertension and oxidative stress in a rat model of L-NAME-induced gestational hypertension. ( Jiang, Z; Zuo, J, 2020) |
| "Melatonin treatment for 8 weeks markedly attenuated cardiac hypertrophy and restored impaired cardiac function, as indicated by a decreased HW/BW ratio, reduced cell cross-sectional area and fibrosis, downregulated the mRNA levels of ANP, BNP, and β-MHC and ameliorated adverse effects on the LVEF and LVFS." | 5.56 | Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. ( Ding, P; Fan, ZG; Gao, EH; Kong, LH; Liu, Y; Xu, CN; Yang, J; Yang, LF, 2020) |
| "Melatonin treatment significantly decreased infarct volume and cerebral apoptosis; mitigated endoplasmic reticulum stress and mitochondrial dysfunction; and inhibited CI/R injury-induced oxidative/nitrative stress and nuclear factor-κB activation, which was eradicated in RORα-deficient mice." | 5.56 | The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin. ( Ai, L; Gao, L; Gao, Y; Petersen, L; Pu, J; Qin, Z; Tong, R; Yan, Y; Zang, M; Zhao, Y; Zhong, F; Zhu, C, 2020) |
| "Multiple sclerosis is a progressive autoimmune disorder of the myelin sheath and is the most common inflammatory disease of young adults." | 5.56 | Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex. ( AboTaleb, HA; Alghamdi, BS, 2020) |
| "Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors." | 5.56 | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder. ( Block, GD; Colwell, CS; Ghiani, CA; Hitchcock, ON; In Kim, Y; Kim, YS; Loh, DH; Luk, SHC; MacDowell Kaswan, ZA; Tahara, Y; Wang, HB, 2020) |
| "Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function." | 5.56 | Cyst Reduction by Melatonin in a Novel ( Gamberi, C; Millet-Boureima, C; Polyak, F; Rozencwaig, R, 2020) |
| "Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction." | 5.56 | A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma. ( Amato, R; Bagnoli, P; Cammalleri, M; Corsaro, R; Dal Monte, M; Pezzino, S; Rusciano, D, 2020) |
| "Severe acute pancreatitis is associated with high morbidity and mortality." | 5.51 | Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. ( Bachmann, K; Erbes, J; Gocht, A; Grupp, K; Havel, J; Izbicki, JR; Mann, O; Poppe, A; Trepte, C; Wodack, K, 2019) |
| "Melatonin has been shown to reduce oxidative stress and mitigate hypercoagulability." | 5.51 | Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model. ( Burd, I; Dong, J; Jia, B; Jones-Beatty, K; Lee, JY; Lei, J; Li, S; McLane, MW; Na, Q; Ozen, M; Shin, NE, 2019) |
| "Melatonin treatment inhibited peripheral tissue inflammation and tissue damage in a cecal ligation puncture (CLP)-induced polymicrobial sepsis model, consequently reducing the mortality of the mice." | 5.51 | Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils. ( Jin, JO; Kwak, M; Lee, PCW; Xu, L; Zhang, L; Zhang, W, 2019) |
| "Melatonin is an effective treatment in MS patients and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS." | 5.48 | Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis. ( Farhadi, N; Ghareghani, M; Sadeghi, H; Zibara, K, 2018) |
| "Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health." | 5.48 | Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. ( Ding, S; Fang, J; Jiang, H; Ma, Y; Zhu, D, 2018) |
| " We examined whether maternal melatonin therapy can prevent maternal high-fructose combined with post-weaning high-salt diet-induced programmed hypertension in adult offspring." | 5.48 | Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. ( Chan, JYH; Lee, WC; Leu, S; Tain, YL; Wu, KLH, 2018) |
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 5.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "Letrozole was administered orally (1 mg kg-1) to induce PCOS condition in Wistar female rats for a period of 2-3 weeks followed by a dose of melatonin (200 µg/100 g b." | 5.48 | Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat. ( Ahmad Hajam, Y; Basheer, M; Ghosh, H; Rai, S, 2018) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 5.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| " A total of 20 landrace pigs were randomized to a dosage of 200 mg (0." | 5.43 | Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction. ( Aarøe, J; Ekeløf, SV; Gögenur, I; Halladin, NL; Jensen, SE; Kjærgaard, B; Rosenberg, J; Simonsen, CW; Zaremba, T, 2016) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 5.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Treatment with melatonin eliminated the deleterious effect of HSD in the kidneys of Dahl salt-sensitive rats." | 5.43 | Melatonin prevents kidney injury in a high salt diet-induced hypertension model by decreasing oxidative stress. ( Barshack, I; Grossman, E; Leibowitz, A; Shemesh, C; Volkov, A; Voloshin, K, 2016) |
| "Melatonin was administrated to rats intraperitoneally (30 mg/kg)." | 5.43 | Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism. ( An, R; Li, H; Liu, H; Shen, G; Sun, L; Xi, C; Zhang, S; Zhao, L, 2016) |
| "Colitis was induced by intracolonic (i." | 5.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD)." | 5.43 | Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease. ( Aleksic, M; Favero, G; Golic, I; Korac, A; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A, 2016) |
| "Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions." | 5.43 | Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. ( Gao, GF; Grailer, JJ; Li, X; Tan, DX; Wang, M; Wang, N; Ward, PA; Yao, J; Zhang, Y; Zhong, R, 2016) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 5.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala." | 5.42 | Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. ( Furuse, M; Goda, R; Iwamoto, A; Kawai, M; Matsuo, H; Nagasawa, M; Nagy, AD; Otsuka, T; Yasuo, S, 2015) |
| "Melatonin has been previously reported to provide neuroprotective effects in in vivo models of stroke by a mechanism that implicates melatonin receptors." | 5.42 | Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. ( Buendia, I; Egea, J; Gameiro, I; Gómez-Rangel, V; González-Lafuente, L; Laudon, M; León, R; López, MG; Michalska, P; Parada, E, 2015) |
| "The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps." | 5.42 | Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015) |
| "In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks." | 5.41 | The Effect of Melatonin on Periodontitis. ( Bábíčková, J; Baňasová, L; Celec, P; Chobodová, P; Janko, J; Konečná, B; Tóthová, Ľ, 2021) |
| "Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice." | 5.40 | The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. ( Acuña-Castroviejo, D; Doerrier, C; Escames, G; García, JA; López, A; López, LC; Luna-Sánchez, M; Ortiz, F; Venegas, C; Volt, H, 2014) |
| "It contributes to the development of acute renal failure." | 5.40 | Effect of a combined treatment with erythropoietin and melatonin on renal ischemia reperfusion injury in male rats. ( Ahmadiasl, N; Alihemati, A; Azimian, E; Banaei, S; Baradaran, B, 2014) |
| "Rats treated with melatonin had higher bone volume, bone trabecular number, trabecular thickness, and cortical thickness in comparison to the control group." | 5.40 | Melatonin dietary supplement as an anti-aging therapy for age-related bone loss. ( Barralet, JE; Calvo-Guirado, JL; Eimar, H; Prieto, S; Tamimi, F; Torres, J; Tresguerres, IF; Tresguerres, JA, 2014) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 5.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Melatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration." | 5.39 | Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats. ( Akman, S; Canakci, CF; Kalkan, Y; Kara, A; Ozkanlar, S; Tozoglu, S; Tozoglu, U, 2013) |
| "Melatonin treatment improved spatial learning and memory and increased the number of choline acetyltransferase (ChAT)-positive cells in the medial septum of both TS and CO mice." | 5.39 | Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. ( Corrales, A; Flórez, J; García, E; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sanchez-Barceló, EJ; Vidal, V, 2013) |
| "Previous studies in rat models of hemorrhagic shock have suggested a benefit." | 5.38 | Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock. ( Beilman, GJ; Greenberg, JJ; Lexcen, DR; Luzcek, E; Mulier, KE, 2012) |
| "Melatonin caused the increase in the pain threshold of the mechanical allodynia and the slight increase in the threshold of the thermal hyperalgesia." | 5.38 | Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 5.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "Melatonin treatment was found to be beneficial in acute pancreatitis." | 5.36 | Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. ( Khanduja, KL; Malhotra, S; Pandhi, P; Sidhu, S; Vaiphei, K, 2010) |
| "Melatonin treatment increased apoptotic cells in endometriotic zones." | 5.36 | Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway. ( Bhattacharya, P; Das Mahapatra, P; Paul, S; Swarnakar, S, 2010) |
| "Global cerebral ischemia induces alterations of working memory, as evidenced in the eight-arm radial maze, in the absence of significant changes of pyramidal neuron population in the prefrontal cortex." | 5.35 | Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats. ( Cervantes, M; García-Chávez, D; González-Burgos, I; Letechipía-Vallejo, G; López-Loeza, E; Moralí, G, 2008) |
| "Uveitis is a common ophthalmic disorder that can be induced in hamsters by a single intravitreal injection of bacterial lipopolysaccharide (LPS)." | 5.35 | Therapeutic effect of melatonin in experimental uveitis. ( Aisemberg, J; Aldana Marcos, HJ; Chianelli, MS; Fernandez, DC; Rosenstein, RE; Sáenz, DA; Sande, PH; Silberman, DM, 2008) |
| "Melatonin (15 mg/kg) was administered by intraperitoneal injection at 1, 24, 48, and 72 h." | 5.35 | Long-term effects of melatonin after intracerebral hemorrhage in rats. ( Ayer, R; Hartman, RE; Jadhav, V; Lee, S; Lekic, T; Rojas, HA; Tang, J; Titova, E; Zhang, JH, 2008) |
| "Fragile X syndrome is the most common form of inherited mental retardation." | 5.35 | Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. ( de Diego-Otero, Y; de Fonseca, FR; Decara, J; Del Arco-Herrera, I; el Bekay, R; Romero-Zerbo, Y; Sanchez-Salido, L, 2009) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the BBB." | 5.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 5.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "Both Melatonin and 1400W were efficient in ameliorating experimental I/R injury of the kidneys." | 5.35 | Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. ( Akgul, EO; Cayci, T; Cetiner, S; Ersoz, N; Guven, A; Korkmaz, A; Oztas, E; Turk, E; Uysal, B, 2009) |
| "The melatonin was administered intraperitoneally at a dose of 5 mg/kg/12 h simultaneously with SAH from day 0 to day 5." | 5.35 | Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. ( Chen, G; Dong, W; Fang, Q; Wang, Z; Zhu, W, 2009) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 5.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "In a model of hemorrhagic shock (MAP 35 +/- 5 mmHg for 90 min) and reperfusion (2 h), we measured nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) autofluorescence, hepatic microcirculation, and hepatocellular injury by intravital microscopy, as well as plasma disappearance rate of indocyanine green (PDRICG) as a sensitive maker of liver function in rat." | 5.35 | Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Pradarutti, S; Rensing, H; Weiler, J; Wolf, B; Ziegeler, S, 2008) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the blood-brain barrier." | 5.35 | Melatonin decreases mortality following severe subarachnoid hemorrhage. ( Ayer, RE; Chen, W; Sugawara, T; Tong, W; Zhang, JH, 2008) |
| "The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 5.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
| "Endometriosis is a gynecological disease of women and plausibly regulated by matrix metalloproteinases (MMPs)." | 5.35 | Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. ( Bhattacharya, P; Mahapatra, PD; Paul, S; Reiter, RJ; Sharma, AV; Swarnakar, S, 2008) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 5.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "Melatonin treatment also resulted with MDA formation (P=0." | 5.34 | The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study. ( Abuşoglu, S; Avunduk, MC; Baysefer, A; Ciçek, O; Kalkan, E; Kalkan, SS; Unlü, A, 2007) |
| "Melatonin treatment prevented qualitative changes in gallbladder neurotransmission, but it did not improve EFS-induced contractility." | 5.34 | Effects of melatonin on gallbladder neuromuscular function in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2007) |
| " We observed that chronic administration of melatonin significantly reduced the lipid peroxidation and restored the decreased glutathione levels induced by chronic hyperhomocysteinemia." | 5.33 | Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats. ( Baydas, G; Koz, ST; Ozer, M; Tuzcu, M; Yasar, A, 2005) |
| "Melatonin or vehicle was administered 1 h before flap elevation and was continued for 6 days after ischemia." | 5.33 | The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats. ( Aydogan, H; Bay-Karabulut, A; Celik, M; Gurlek, A; Parlakpinar, H, 2006) |
| "Melatonin was administered as an antioxidant." | 5.32 | Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. ( Nava, M; Quiroz, Y; Rodriguez-Iturbe, B; Vaziri, N, 2003) |
| "Treatment with melatonin at 1." | 5.32 | Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Fung, PC; Pei, Z, 2003) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 5.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| "Melatonin was administered either 10 min before aortic occlusion or 10 min after the clamp was removed." | 5.32 | Protective effect of melatonin on experimental spinal cord ischemia. ( Aydemir, S; Colak, A; Erten, SF; Kocak, A; Ozdemir, I; Reeder, BS, 2003) |
| " However, one dosage pretreatment, but not post-treatment, of baicalein (5 or 10 mg/kg, i." | 5.32 | Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. ( Chen, CF; Chi, CW; Liao, JF; Wang, HH; Wang, SY, 2004) |
| "Pretreatment with melatonin dramatically improved survival rate of rats when compared with the I/R-only group." | 5.31 | Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. ( Chen, HR; Hsiao, G; Lee, YM; Sheu, JR; Wang, JJ; Yen, MH, 2002) |
| " Chronic administration of melatonin (0." | 5.31 | Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. ( Kulkarni, SK; Raghavendra, V, 2001) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 5.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| "Scoliosis was assessed on weekly radiographs, and the Cobb angle was determined for all chickens in which scoliosis developed." | 5.30 | The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken. ( Bagnall, K; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Zhao, J, 1999) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 5.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Melatonin, the main pineal secreting hormone, has been extensively studied in primary and secondary headache disorders." | 5.01 | Current understanding of pineal gland structure and function in headache. ( Amaral, FG; Cipolla-Neto, J; Peres, MF; Valença, MM, 2019) |
| " There has also been a marked increase in the prevalence of metabolic syndrome in recent decades, which has been associated with a reduction in nocturnal pineal production of melatonin with aging and an increased risk of coronary diseases, type 2 diabetes mellitus (T2DM) and death." | 4.90 | Melatonin and metabolic regulation: a review. ( A-Serrano, MM; Acuña-Castroviejo, D; Agil, A; Blanca-Herrera, RM; Fernández-Vázquez, G; Navarro-Alarcón, M; Ruiz-Ojeda, FJ, 2014) |
| "This review summarizes the numerous reports that have documented the neuroprotective actions of melatonin in experimental models of ischemia/reperfusion injury (stroke)." | 4.82 | Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. ( Lopez-Burillo, S; Manchester, LC; Mayo, JC; Reiter, RJ; Sainz, RM; Tan, DX, 2003) |
| "Melatonin is a candidate neuroprotective drug for ischaemic stroke." | 4.82 | Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. ( Donnan, GA; Horky, LL; Howells, DW; Macleod, MR; O'Collins, T, 2005) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 4.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "Conflicting results on melatonin synthesis in multiple sclerosis (MS) have been reported due to variabilities in patient lifestyles, which are not considered when supplementing melatonin." | 4.31 | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis. ( Ghareghani, M; Laflamme, N; Pons, V; Rivest, S; Zibara, K, 2023) |
| "The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 4.12 | Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022) |
| "To investigate the influence of melatonin on behavioral and neurological function of rats with focal cerebral ischemia-reperfusion injury via the JNK/FoxO3a/Bim pathway." | 4.12 | Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway. ( Chen, X; Deng, Y; Lai, J; Ou, Y; Peng, X; Shen, X; Wu, H; Wu, L; Yao, Z; Zhu, H, 2022) |
| " Inducing colitis by dextran sodium sulfate (DSS), HA-MT accumulated in the inflamed colon epithelium of colitis mice, and markedly improved the colitis symptoms, repaired the damaged intestinal barrier and inhibited colon inflammation." | 4.12 | Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis. ( Dong, S; Jing, W; Liu, W; Wang, F; Wang, K; Wang, S; Xu, Y; Yang, J; Zhao, X; Zhu, M, 2022) |
| "Reduced levels of retinal dopamine, a key regulator of eye development, are associated with experimental myopia in various species, but are not seen in the myopic eyes of C57BL/6 mice, which are deficient in melatonin, a neurohormone having extensive interactions with dopamine." | 4.12 | Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia. ( Chen, WH; Cui, LJ; Gong, X; Huang, F; Li, YY; Liu, AL; Liu, YF; Ma, YY; Qian, KW; Qu, J; Wang, Q; Weng, SJ; Wu, XH; Yang, XL; Yang, Z; Yu, CX; Zhong, YM; Zhou, X, 2022) |
| "Reduction of epigenetic target, EZH2 by melatonin significantly improves the clinical symptoms of dextran sodium sulphate induced colitis and may be implicated as a potential therapeutic target in IBD management." | 4.12 | Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models. ( Biswal, L; Choudhury, SR; Dev, A; Karmakar, S; Kushwaha, AC; Mohanbhai, SJ; Sardoiwala, MN; Sharma, SS, 2022) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 4.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| " Melatonin treatment suppresses ferroptosis and alleviates kidney injury in the context of experimental sepsis by upregulating Nrf2/HO-1 pathway." | 4.12 | Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. ( An, S; Chen, Z; Gao, Y; Li, J; Lin, B; Lin, X; Qiu, W; Wang, T; Yu, B; Zeng, Z, 2022) |
| "Melatonin (MT), a neurohormone with immunomodulatory properties, is one of the metabolites produced in the brain from tryptophan (TRP) that has already strong links with the neuropathogenesis of Multiple sclerosis (MS)." | 4.12 | Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway. ( Ejtemaei-Mehr, S; Ghahremani, MH; Ghanbari, A; Ghazi-Khansari, M; Guillemin, GJ; Jand, Y, 2022) |
| "Melatonin is a potent neuroprotective agent which has shown therapeutic effects in animal models of brain injury such as stroke." | 4.12 | Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke. ( Cambiaghi, M; Cherchi, L; Comai, S, 2022) |
| "Melatonin (MLT) was reported to have therapeutic effects on inflammatory bowel disease (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) due to its anti-inflammatory and immunomodulatory properties." | 4.12 | RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. ( Deng, Y; Fei, S; Feng, S; Li, L; Mo, Y; Song, J; Wang, K; Wu, J; Xu, Z; Zhang, Q; Zhang, Z; Zhou, R, 2022) |
| " In addition, the present results suggest that melatonin supplementation attenuates adipose-hepatic metabolic dysfunction, accompanying obesity by suppression of oxidative stress/inflammation-dependent mechanism and increasing circulating obestatin." | 4.02 | Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model. ( Akintayo, CO; Atuma, CL; Aturamu, A; Badejogbin, OC; Mahmud, H; Obayemi, MJ; Olaniyi, KS; Oniyide, AA; Saidi, AO, 2021) |
| "Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin." | 4.02 | Melatonin improves periodontitis-induced kidney damage by decreasing inflammatory stress and apoptosis in rats. ( Akyildiz, K; Altin, A; Arabaci, T; Bostan, SA; Emre Kose, T; Kose, O; Kuluslu, G; Kurt Bayrakdar, S; Mercantepe, T; Tumkaya, L; Turker Sener, L; Unver, B; Yilmaz, A, 2021) |
| "This study aimed to investigate the protective effect of melatonin on the corneal epithelium in dry eye disease(DED) and explore its underlying mechanism." | 4.02 | Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye. ( Li, S; Ouyang, H; Peng, L; Wang, B; Wang, L; Wang, X; Xiao, Y; Yuan, J; Zeng, H; Zhong, J; Zuo, X, 2021) |
| " Melatonin is involved in the outcome of normal pregnancy." | 4.02 | Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia. ( Aref, M; El-Malkey, NF; Emam, H; Khalil, SS, 2021) |
| "Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1-7)." | 4.02 | Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction. ( An, S; Chen, Z; Fang, H; Han, Y; Huang, Q; Li, L; Wu, J; Xu, S; Zeng, Z, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 4.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| "Over the past few years, ozone has been identified as a potential risk factor for exacerbating asthma." | 4.02 | Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway. ( Chen, Y; Li, J; Liu, X; Wu, X; Yang, X; Zeng, Y, 2021) |
| "Intraperitoneal injections of exogenous melatonin during the development of the retinal vascular system in experimental rats has been shown in a number of experimental studies on the model of EROP to prevent the appearance of histological signs of the development of experimental retinopathy of prematurity (EROP), stabilize the blood-retinal barrier and have a pronounced antioxidant effect, but pathogenetic basis for these phenomena hasn't been studied." | 4.02 | [Pathogenetically oriented approach to prevention of retinopathy of prematurity (experimental study)]. ( Beznos, OV; Chesnokova, NB; Katargina, LA; Osipova, NA; Panova, AY, 2021) |
| " Our previous studies found that melatonin exerts an improvement effect in sleep deprivation (SD)- induced corticosterone overproduction and colitis." | 4.02 | Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2021) |
| "The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS." | 4.02 | Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model. ( Chen, J; Chen, XG; Du, HX; Liang, CZ; Liu, Y; Wen, LP; Zhan, CS; Zhang, L; Zhang, LG; Zhang, M, 2021) |
| " This study investigated the potential effects of luzindole on LPS/d-galactosamine (d-GalN)-induced acute hepatitis." | 3.96 | Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. ( Huang, J; Li, L; Luo, Y; Shen, Y; Tang, L; Yang, Y; Zhang, L, 2020) |
| "The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model." | 3.96 | Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants. ( Akbulut, HF; Sekmenli, T; Vatansev, H, 2020) |
| " The aim of this study was to evaluate a combination consisting of a ketogenic diet and melatonin to determine whether it would inhibit cisplatin- and vincristine-resistant breast cancer." | 3.96 | A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. ( Talib, WH, 2020) |
| " Liver damage, markers of glucose metabolism, inflammation, intestinal barrier function and melatonin metabolism were determined." | 3.96 | Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis. ( Baumann, A; Bergheim, I; Brandt, A; Burkard, M; Jin, CJ; Nier, A; Sellmann, C; Venturelli, S, 2020) |
| "This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF-κB signaling pathway." | 3.96 | Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc. ( Chen, F; Li, Z; Liu, H; Pei, Y; Wang, J; Wang, X; Zhang, J; Zheng, Z, 2020) |
| "We aimed to study the effect and mechanism of retinal melanopsin on lens-induced myopia in guinea pigs, as well as the interactions between melanopsin and other myopic regulation neurotransmitters such as dopamine and melatonin, and to explore the possible role of melanopsin in the prevention of myopia development." | 3.96 | Regulation of Retinal Melanopsin on Lens-induced Myopia in Guinea Pigs. ( Chen, Y; Guan, X; Mao, J; Zhang, X; Zheng, W; Zhou, X, 2020) |
| "This study sought to investigate a novel effect of melatonin in reducing brain injury in an in vivo hyperglycemic intracerebral hemorrhage (ICH) model and further explore the mechanisms of protection." | 3.96 | Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats. ( Liang, F; Shi, L; Sun, Z; Wang, J; Wang, Z; Xu, S; Zhang, J; Zheng, J; Zhou, J; Zhu, X, 2020) |
| "Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism has not been identified." | 3.96 | Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury. ( Cui, JW; Ma, X; Wei, LL; Yang, B; Zang, LE; Zhang, MY, 2020) |
| "An emerging area in schizophrenia research focuses on the impact of immunomodulatory drugs such as melatonin, which have played important roles in many biological systems and functions, and appears to be promising." | 3.96 | Schizophrenia-like behavior is not altered by melatonin supplementation in rodents. ( Afonso, AC; Bialecki, AVS; Bischoff, LM; Canever, L; Godoi, AK; Hubbe, I; Mastella, GA; Pacheco, FD; Wessler, PG; Zugno, AI, 2020) |
| "Melatonin (N‑acetyl‑5‑methoxytryptamine; MT) has been shown to have a protective effect against sepsis‑induced renal injury, however, the mechanisms underlying the function of MT remain to be elucidated." | 3.91 | Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway. ( Dai, W; Deng, Y; Hu, S; Huang, H; Si, L; Xu, L; Zhou, L, 2019) |
| " Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model." | 3.91 | Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model. ( Cui, K; Liu, J; Ruan, Y; Song, J; Tang, Z; Wang, S; Wang, T; Yang, J; Yu, Z, 2019) |
| "Melatonin is a neurohormone that is linked to the pathogenesis of schizophrenia." | 3.91 | Reversal of Schizophrenia-like Symptoms and Cholinergic Alterations by Melatonin. ( Akram, M; Andrabi, SS; Kaushik, M; Parveen, K; Parvez, S; Tabassum, H; Vishnoi, S, 2019) |
| "Melatonin is reportedly associated with intervertebral disc degeneration (IDD)." | 3.91 | Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway. ( Chen, T; Gao, W; Jin, H; Lin, J; Nisar, M; Tian, N; Wang, C; Wang, Q; Wang, X; Wu, Y; Xu, T; Zhang, X; Zhang, Z; Zheng, G; Zhou, Y, 2019) |
| "A high-fat diet (FD)-induced obesity mouse model was subjected to intermittent hypoxia/normoxia events for approximately 8 h per day using an autophagy agonist, rapamycin, or an inhibitor, 3-methyladenine (3-MA), and SRT1720, a sirtuin 1 (SIRT1) activator, or sirtinol, a SIRT1 inhibitor, with or without melatonin for a total of six successive weeks, followed by assessment of expression of autophagy-related genes and activity of serum aminotransferase as well as histological evaluation of tissue morphology." | 3.91 | Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. ( Han, Y; Jin, M; Li, GC; Liu, HG; Luo, M; Ren, J; You, ZX, 2019) |
| "Despite melatonin treatment diminishes inflammatory mediator production and improves organ injury after acute pancreatitis (AP), the mechanisms remain unknown." | 3.91 | Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway. ( Chen, TH; Cheng, HT; Chiang, KC; Hsu, JT; Kuo, CJ; Le, PH; Lin, CJ; Wu, RC, 2019) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 3.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| " Emerging evidence suggests pleiotropic roles of melatonin in cardiac disease; however, the effects of melatonin on physiological vs pathological cardiac hypertrophy remain unknown." | 3.91 | Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. ( Gao, L; Gao, Y; Ji, Q; Lan, F; Pu, J; Sheng, X; Su, Y; Tong, R; Wu, F; Xu, L; Yan, Y; Ying, X; Yuan, A; Zhao, Y, 2019) |
| "Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury." | 3.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| "To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL)." | 3.91 | Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome. ( Bosco, AD; Colares, JR; Dias, AS; Forgiarini Junior, LA; Hartmann, RM; Marroni, NP; Schedler, FB; Schemitt, EG, 2019) |
| " The aim of the present study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of antibiotics and/or melatonin treatments on diet-induced hepato-intestinal dysfunction and inflammation." | 3.91 | The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats. ( Akdeniz, E; Aksu, B; Arabacı Tamer, S; Bagriacik, F; Cayirli, YB; Çetinel, Ş; Cilingir Kaya, ÖT; Kahraman, MM; Onur, ND; Sahin, D; Yeğen, BÇ; Yildirim, A; Yuksel, M, 2019) |
| "To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis." | 3.88 | Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018) |
| "We aimed to compare the neuroprotective effects of brimonidine tartrate (BRT) and melatonin (MEL) on retinal ganglion cells (RGCs) in a rat glaucoma model." | 3.88 | Comparison of the neuroprotective effects of brimonidine tartrate and melatonin on retinal ganglion cells. ( Ciftci, F; Eyuboglu, S; Gumusel, A; Guzel, E; Marangoz, D; Seckin, I; Yalvac, I; Yilmaz, B, 2018) |
| "This study demonstrated that melatonin pretreatment attenuated lung ischaemia-reperfusion injury via inhibition of oxidative stress, inflammation and apoptosis." | 3.88 | Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. ( Wang, JJ; Wang, JS; Wang, ML; Wang, WD; Wei, CH; Zhang, J, 2018) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 3.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| " Aim The present study aims to examine the effect of melatonin supplementation and pinealectomy on leptin, neuropeptide Y (NPY), melatonin and zinc levels in rats with hypothyroidism and hyperthyroidism." | 3.88 | Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland. ( Baltaci, AK; Mogulkoc, R, 2018) |
| " We now assessed lymphatic Aβ clearance by treating a mouse model of AD amyloidosis with melatonin, an Aβ aggregation inhibitor and immuno-regulatory neurohormone." | 3.88 | Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis. ( Matsubara, E; Pacheco-Quinto, J; Pappolla, MA; Poeggeler, B; Sambamurti, K; Vidal, R; Zagorski, M, 2018) |
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 3.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "It seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain." | 3.88 | Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish. ( Abbate, F; Germanà, A; Guerrera, MC; Laura, R; Levanti, M; Mania, M; Montalbano, G; Navarra, M; Vega, JA, 2018) |
| "d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models." | 3.88 | Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. ( Beilman, GJ; Mulier, KE; Suryanarayanan, R; Thakral, S; Wolf, A, 2018) |
| "To evaluate m-RNA expressions of SERCA2 and NCX1 in acute pancreatitis induced by sodium taurocholate in Wistar rats pre-treated with melatonin and/or TD." | 3.88 | THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE. ( Chaib, E; Coelho, AM; Cunha, JEM; D'Albuquerque, LAC; Kubrusly, MS; Lima, MA; Nader, HB; Sanpietri, SN; Tersariol, ILS; Vasques, ER, 2018) |
| "Melatonin has been shown to inhibit myocardial infarction-induced apoptosis, its function in heart failure with preserved ejection fraction (HFpEF) has not been investigated." | 3.88 | Melatonin improves cardiac function in a mouse model of heart failure with preserved ejection fraction. ( Dong, JZ; Gao, L; Guo, S; Li, L; Li, LN; Liang, C; Liu, Y; Liu, YZ; Tu, S; Wang, D; Yang, HB; Zhao, XY, 2018) |
| "To evaluate the potential of a poly(lactic-co-glycolic acid) (PLGA)-based slow release formulation of glial cell line-derived neurotrophic factor (GDNF) alone or in combination with melatonin to rescue photoreceptors in a mouse model of retinal degeneration." | 3.88 | Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice. ( Arranz-Romera, A; Baranov, P; Bravo-Osuna, I; García-Caballero, C; Herrero-Vanrell, R; Lieppman, B; Molina-Martínez, IT; Young, M, 2018) |
| "The application of the melatonin antagonist of Luzindole can improve the success rate of the bipedal rat scoliosis model." | 3.85 | The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model. ( Jiang, J; Jin, X; Lu, F; Ma, X; Xia, X; Yang, S; Zheng, C; Zhu, W, 2017) |
| "Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice." | 3.85 | Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. ( Beker, MC; Caglayan, AB; Caglayan, B; Gunal, MY; Gundogdu, RZ; Kelestemur, T; Kerman, BE; Kilic, E; Kilic, U; Yalcin, E; Yılmaz, B; Yulug, B, 2017) |
| " The aim of this study is to investigate whether iron overload causes the apoptosis and necrosis of bone marrow mesenchymal stem cells (BMSCs) and melatonin may prevent its toxicity." | 3.85 | Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin. ( Bao, Z; Cai, B; Ding, F; Du, Z; Feng, C; Gong, R; Han, Z; Hua, B; Huang, Q; Idiiatullina, E; Li, Y; Liu, T; Ma, W; Pavlov, V; Wang, X; Yan, G; Yang, F; Yang, L; Yu, Y; Yuan, Y; Zhang, L, 2017) |
| "Melatonin is a neurohormone that is linked to the aetiopathogenesis of schizophrenia." | 3.85 | Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia. ( Aina, OA; Onaolapo, AY; Onaolapo, OJ, 2017) |
| "The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM)." | 3.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| " The altered proteins are related to the development of liver pathology, such as cirrhosis (α1-antiproteinase), thrombosis (fibrinogen, plasminogen), and inflammation (mannose-binding protein A, complement C4, complement factor B), contributing to liver steatosis or hepatic cell death." | 3.85 | High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation. ( Govitrapong, P; Isarankura-Na-Ayudhya, C; Kitidee, K; Klosen, P; Pannengpetch, S; Wongchitrat, P, 2017) |
| "Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol." | 3.85 | Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. ( Chen, X; Duan, W; Jin, Z; Jing, L; Li, B; Li, K; Liang, H; Liu, J; Liu, Z; Reiter, RJ; Ren, K; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, B; Yu, S; Zhai, M; Zhang, B; Zhang, M, 2017) |
| "Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome." | 3.85 | Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Diego, M; García-Cerro, S; Lantigua, S; Martínez-Cué, C; Parisotto, EB; Rueda, N; Sanchez-Barceló, EJ; Vidal, V; Wilhem Filho, D, 2017) |
| "Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury." | 3.85 | Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017) |
| " This study explored the hypothesis that melatonin has beneficial functions in the mouse model of colitis induced by dextran sodium sulfate (DSS), with a specific focus on the expression of intestinal inflammatory cytokines and the serum levels of amino acids." | 3.85 | Melatonin alters amino acid metabolism and inflammatory responses in colitis mice. ( Chen, S; Fang, J; Jiang, Q; Liu, G; Ren, W; Yao, K; Yin, J; Yin, Y, 2017) |
| "Morphine is a widely used analgesic for various types of pain." | 3.85 | Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. ( Fan, Y; Liang, X; Song, L; Wang, R, 2017) |
| "Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models." | 3.85 | D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study. ( Beilman, GJ; Mulier, KE; Muratore, SL; Wolf, A, 2017) |
| "The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis." | 3.85 | Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis. ( Albayrak, M; Arabaci, T; Erdemci, B; Gedikli, S; Kara, A; Kermen, E; Kizildag, A; Köse, O; Özkal Eminoğlu, D; Özkanlar, S; Zihni, M, 2017) |
| "To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma." | 3.85 | Elevated intraocular pressure increases melatonin levels in the aqueous humour. ( Alkozi, H; Carracedo, G; de Lara, MJ; Fonseca, B; Martinez-Aguila, A; Pintor, J; Sánchez-Naves, J, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 3.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| "Immune dysregulation observed in schizophrenia alters tryptophan metabolism." | 3.85 | Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs. ( Cordeiro, RC; da Silva Araújo, T; de Freitas Lima, R; de Jesus Souza Machado, M; Freitas de Lucena, D; Isabelle de Góis Queiroz, A; Macêdo, D; Maes, M; Maia Chaves Filho, AJ; Monte, AS, 2017) |
| "The present study was aimed at evaluating the rapidity and duration of melatonin as an antidepressant in a rat model of depression." | 3.85 | Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress. ( Li, Q; Lian, B; Sun, H; Sun, L; Sun, X; Wang, G; Wang, M; Wang, Y, 2017) |
| "The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs." | 3.85 | Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats. ( Al-Rasheed, NM; Attia, HA; Fadda, L; Mohamed, AM; Sharaf, IA, 2017) |
| "The influence of melatonin on the reduced glutathione content, activity of glutathione peroxidase, glutathione reductase, and glutathione transferase in blood serum, heart, liver, and skeletal muscle of rats under conditions of experimental rheumatoid arthritis development has been estimated." | 3.83 | [EFFECT OF MELATONIN ON THE GLUTATHIONE ANTIOXIDANT SYSTEM ACTIVITY IN RAT TISSUES UNDER CONDITIONS OF EXPERIMENTAL RHEUMATOID ARTHRITIS.] ( Makeeva, AV; Popova, TN; Safonova, OA; Synorova, AA, 2016) |
| "Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function." | 3.83 | Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016) |
| "Melatonin was effective in the treatment of experimental endometriosis induced in SCID mice." | 3.83 | The effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in the first SCID-mouse endometriosis-model developed in Turkey. ( Akkaya, H; Attar, R; Ozkan, F; Yesildaglar, N; Yildirim, G; Yildirim, OK; Yilmaz, B, 2016) |
| "Previous studies have demonstrated that melatonin administration improves spatial learning and memory and hippocampal long-term potentiation in the adult Ts65Dn (TS) mouse, a model of Down syndrome (DS)." | 3.83 | Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome. ( García-Cerro, S; Lantigua, S; Martínez-Cué, C; Parisotto, EB; Rueda, N; Sanchez-Barceló, EJ; Vidal, V; Wilhelm Filho, D, 2016) |
| "Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS)." | 3.83 | Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis. ( Ariyannur, PS; Kirmani, BF; Moffett, JR; Namboodiri, AM; Ribeiro, R; Tanaka, M; Wen, J; Zhang, Y, 2016) |
| "The aim of this study was to estimate the effect of melatonin on spinal cord perfusion, the permeability of blood-spinal cord barrier (BSCB), and edema at the contusion epicenter and regions rostral and caudal to the injury site in rats with spinal cord injury (SCI)." | 3.83 | Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry. ( Bai, F; Chen, H; Dong, H; Jing, Y, 2016) |
| "The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus." | 3.83 | Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus. ( Arkhipov, SA; Ishchenko, IY; Klimontov, VV; Konenkov, VI; Michurina, SV; Rachkovskaya, LN; Zavyalov, EL, 2016) |
| "To explore the effects of Kaixin Powder (, KXP) on melatonin receptor (MR) expression and (125)I-Mel binding affinity in a depression rat model." | 3.81 | Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. ( Cai, C; Gao, C; Guan, JH; Guo, J; Huang, YL; Liang, XB; Qian, LQ; Zhao, GP, 2015) |
| "Melatonin (MLT) is an endogenous indole compound with numerous biological activities that has been associated with atherosclerosis (AS)." | 3.81 | Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits. ( Cheng, X; Wan, Y; Wang, Y; Xu, Y; Zhou, Q; Zhu, H, 2015) |
| " We aimed to investigate the proteins related to oxidative stress, inflammation and apoptosis in liver tissue subjected to IH as a simulation of sleep apnea in conjunction with the administration of either melatonin (MEL, 200 μL/kg) or N-acetylcysteine (NAC, 10 mg/kg)." | 3.81 | Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea. ( Andrade, CF; da Rosa, DP; e Silva, MB; Fiori, CZ; Forgiarini, LF; Marroni, NP; Martinez, D, 2015) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 3.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| " Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized." | 3.81 | Melatonin improves experimental colitis with sleep deprivation. ( Baik, HW; Chung, SH; Kim, DS; Kim, JB; Kim, JH; Kim, TK; Lee, SK; Park, YS, 2015) |
| "The aim of this study was to determine the effects of some polyunsaturated fatty acids plus phytomelatonin from walnuts in the development of mammary gland adenocarcinoma." | 3.81 | Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model. ( Berra, MA; Comba, A; Das, UN; Eynard, AR; Garcia, CP; Labuckas, DO; Lamarque, AL; Pasqualini, ME; Silva, RA, 2015) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 3.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 3.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 3.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| " Interestingly, the hypoxia-induced increase of nNOS, eNOS, iNOS, Ntyr and Caspase 3 protein expression was significantly depressed in the hypoxic rats treated with melatonin." | 3.81 | Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus. ( Chen, KT; Fu, PI; Huang, CC; Jou, MJ; Lai, CJ; Tsai, MH; Wei, IH; Wu, CH; Wu, YC, 2015) |
| "Experiments with mice showed that in a multitude of acute hypoxia models (normobaric hypoxic hypoxia with hypercapnia, hypobaric, hemic and histotaxic) the antihypoxic action of a single intra-abdominal dose of melatonin surpasses greatly amtisol, the standard antihypoxic agent." | 3.81 | [STUDIES OF THE ANTIHYPOXIC AND ANTIAMNESTIC EFFECTS OF MELATONIN IN ANIMALS]. ( Chelnaya, NA; Ivanov, YV; Karsanova, SK; Motin, VG; Yasnetsov, VV, 2015) |
| "Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects." | 3.80 | Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis. ( Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M, 2014) |
| "Resveratrol/melatonin combination effectively normalizes anthropometrical, biochemical, and histopathological parameters in ovariectomized rats with fructose diet-induced obesity and associated metabolic alterations." | 3.80 | Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats. ( Giri, PR; Majumdar, AS; Pai, SA, 2014) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 3.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "The present study aimed to evaluate the therapeutic effects of melatonin on either ghrelin secretion or gastric mucosal injury in acute necrotizing pancreatitis (ANP)." | 3.80 | Melatonin reduces inflammation and recovers endogenous ghrelin in acute necrotizing pancreatitis in rats. ( Huang, JA; Liang, ZH; Qin, MB; Su, J; Tang, GD; Yang, HY, 2014) |
| "Aluminum (Al) is a known neurotoxic element involved in the etiology of some serious neurodegenerative disorders such as Alzheimer disease (AD)." | 3.80 | Chronic exposure to aluminum and melatonin through the diet: neurobehavioral effects in a transgenic mouse model of Alzheimer disease. ( Colomina, MT; Di Paolo, C; Domingo, JL; Gómez, M; Reverte, I, 2014) |
| "The aim of the work was investigation of both humoral and cell-mediated immunity together with leukocytes functional stability indexes in rats with the experimental contact dermatitis (ECD) in conditions of complex pharmacological correction using deltaran and melatonin." | 3.80 | [Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis]. ( Shandra, OO, 2014) |
| " The rats were then randomly allocated to fracture, fracture-ischemia, fracture- ischemia-melatonin, and fracture-ischemia-CAPE groups." | 3.80 | The effects of melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions. ( Aşçı, M; Bostan, B; Erdem, M; Gülabi, D; Güneş, T; Köseoğlu, RD, 2014) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 3.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "These results indicate that treatment with melatonin, starting after the onset of uveitis, attenuated ocular inflammation induced by LPS in the Syrian hamster and support the use of melatonin as a therapeutic resource for uveitis treatment." | 3.80 | Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation. ( Chianelli, M; Domínguez Rubio, AP; Dorfman, D; Fernandez, DC; Franchi, AM; Rosenstein, RE; Sáenz, DA; Sande, PH; Silberman, DM, 2014) |
| "The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi." | 3.80 | Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. ( Kireev, RA; Tresguerres, JA; Vara, E; Viña, J, 2014) |
| "This study was undertaken to study the effects of melatonin on metabolic and reproductive aspects of polycystic ovary syndrome (PCOS) in rats." | 3.80 | Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. ( Majumdar, AS; Pai, SA, 2014) |
| "Production of reactive oxygen species was strongly increased in the aorta and liver after 5h of polymicrobial sepsis which was entirely inhibited by treatment with melatonin." | 3.80 | Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response. ( Fink, T; Kleber, A; Kubulus, D; Rössler, D; Speer, T; Volk, T; Wolf, B, 2014) |
| "The aim of the study was to examine the reorganization of extracellular matrix left ventricular myocardium (LVM) rats (n = 38) with experimental heart failure (EHF) as affected by perindopril and melatonin administration." | 3.80 | [Extracellular matrix remodeling myocardium of the left ventricle rats with experimental heart failure after perindopril and melatonin administration]. ( Liskova, IuV; Salikova, SP; Stadnikov, AA, 2014) |
| " Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition." | 3.79 | Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013) |
| "The results showed that thiamine pyrophosphate prevented ischemia/reperfusion injury-related infertility, but melatonin did not provide adequate prevention." | 3.79 | Use of thiamine pyrophosphate to prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary. ( Borekci, B; Cetin, N; Gul, MA; Turan, MI; Yapca, OE, 2013) |
| " Melatonin, with its antioxidative and anti-inflammatory effects, is known to modulate the response to endotoxemia." | 3.79 | Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. ( Alamili, M; Gögenur, I; Klein, M; Lykkesfeldt, J; Rosenberg, J, 2013) |
| "Decline with age of the content of melatonin is considered as one of the leading mechanisms of aging and development of associated diseases, including age-related macular degeneration (AMD)--the disease, which becomes the most common cause of blindness and acuity of vision deterioration in elderly." | 3.79 | [Potential of melatonin for prevention of age-related macular degeneration: experimental study]. ( Fursova, AZh; Kolosova, NG; Stefanova, NA; Zhdankina, AA, 2013) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 3.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| " This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti-inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)-induced colitis in pinealectomized (Px) rats." | 3.79 | Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis. ( Acet, A; Kaya, E; Parlakpinar, H; Tasdemir, S; Vardi, N, 2013) |
| "Although melatonin has been implicated in several neurophysiological systems, data on the relationship of melatonin with psychosis such as schizophrenia are limited and contradictory." | 3.79 | Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats. ( Acet, A; Akdag, E; Celik, T; Kayir, H; Kose, A; Parlakpinar, H; Ulusoy, G; Uzbay, T; Yararbas, G, 2013) |
| "The vasopressin and oxytocin content of the hypothalamus and neurohypophysis, as well as their plasma levels, were radioimmunoassayed in sham-operated or pinealectomized rats with left coronary artery ligation (CAL)-evoked myocardial infarction as well as under melatonin treatment." | 3.78 | Function of the hypothalamo-neurohypophysial system in rats with myocardial infarction is modified by melatonin. ( Ciosek, J; Drobnik, J, 2012) |
| "The aim of this study was to investigate the effects of melatonin on glucose homeostasis in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 3.78 | Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats. ( Agil, A; Fernández-Vázquez, G; Figueroa, A; Rosado, I; Ruiz, R; Zen, N, 2012) |
| "Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms." | 3.78 | Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. ( Chen, G; He, WC; Huo, L; Liu, HX; Ma, C; Meng, CJ; Shen, XM; Shu, Z; Sun, XB; Wang, Z; Zhang, J; Zhu, GQ, 2012) |
| "The gastroprotective action of synthetic dipeptides glutamyl-tryptophane (EW), iso-valeroyl-glutamyl-tryptophane (ivEW) and nicotinoyl-glutamyl-tryptophane (nEW) in comparison to melatonin was studied in experiments on male with the model indometacine and starvation stress-induced stomach ulcers." | 3.78 | [Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin]. ( Malinin, VV; Savateeva-Liubimova, TN; Sivak, KV, 2012) |
| "Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety." | 3.78 | Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. ( Bedini, A; Comai, S; Fraschini, F; Gobbi, G; Mor, M; Ochoa-Sanchez, R; Rainer, Q; Rivara, S; Spadoni, G; Tarzia, G, 2012) |
| "To compare the efficacy of ozone with melatonin, shown as the most powerful antioxidant in attenuation of testicular ischemia/reperfusion injury, in an experimental rat model of testicular torsion/detorsion." | 3.78 | Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats. ( Benli Aksungar, F; Doğan Ekici, AI; Ekici, S; Lüleci, N; Öztürk, G; Sinanoğlu, O; Turan, G, 2012) |
| "To study the effect of Kaixin San on the rate-limiting enzyme in biosynthesis of melatonin (MT) and pineal body in rat depression model." | 3.78 | [Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model]. ( Cai, C; Liang, X; Peng, X; Qian, G; Zhao, G, 2012) |
| "In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated." | 3.77 | The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011) |
| "The efficacy of melatonin treatment in experimental stroke has been established." | 3.77 | Melatonin treatment following stroke induction modulates L-arginine metabolism. ( Appleton, I; Clarkson, AN; Nair, SM; Rahman, RM; Sammut, IA; Sutherland, BA; Taurin, S, 2011) |
| "In this study, the effects of melatonin or beta-glucan treatments on tumor growth, pro-oxidant, and antioxidant status in tumor tissue were investigated in Dunning 3327 MatLyLu prostatic adenocarcinoma model." | 3.77 | Melatonin and beta-glucan alone or in combination inhibit the growth of dunning prostatic adenocarcinoma. ( Balkan, J; Doğru-Abbasoğlu, S; Kabasakal, L; Keyer-Uysal, M; Sener, G; Uysal, M, 2011) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 3.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| "This experimental study was designed to produce ischemia-reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters." | 3.76 | An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. ( Akbas, A; Atılgan, D; Erdemir, F; Erkorkmaz, U; Parlaktas, BS; Uluocak, N; Yasar, A, 2010) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 3.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats." | 3.76 | Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. ( Ayer, R; Chen, W; Hartman, R; Lekic, T; Manaenko, A; Rojas, H; Tang, J; Zhang, JH, 2010) |
| "Previous reports suggest that melatonin may play an important role in visceral nociception and neurogenic inflammation." | 3.76 | Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. ( Mickle, A; Miranda, A; Sengupta, JN; Shahmohammadi, G; Sood, M; Zhang, Z, 2010) |
| "The present study was designed to evaluate whether the administration of s-methylisothiourea and melatonin has protective potential in intestinal ischemia/reperfusion injury." | 3.76 | Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats. ( Atabek, C; Demirin, H; Karaoglu, A; Kesik, V; Korkmaz, A; Kul, M; Ozler, M; Oztas, E; Sadir, S; Temiz, A; Tunc, T, 2010) |
| "The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes." | 3.76 | Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. ( Balaraman, R; Patel, V; Upaganlawar, A; Zalawadia, R, 2010) |
| "To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism." | 3.76 | [Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats]. ( Ding, CH; Dong, YJ; Gu, WW; Suo, XH, 2010) |
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 3.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "The effects of pinealectomy on the progression of endometriosis explants were reversed by melatonin." | 3.76 | Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model. ( Bugdayci, G; Duran, B; Gunduz, B; Koc, O; Topcuoglu, A; Yilmaz, F, 2010) |
| "This study investigated the effect of aging-related parameters such as inflammation, oxidative stress and cell death in the heart in an animal model of accelerated senescence and analyzed the effects of chronic administration of melatonin on these markers." | 3.76 | Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. ( Acuña-Castroviejo, D; Cuesta, S; Forman, K; García, C; Kireev, R; Tresguerres, JA; Vara, E, 2010) |
| "To investigate the expression of melatonin MT1 receptor in rats with acute necrotizing pancreatitis (ANP) and the protective effects of melatonin (MT) pre-intervention for the pancreas." | 3.76 | [The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin]. ( Chen, LQ; Gao, DJ; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Zhai, K, 2010) |
| "The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis." | 3.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "Pinealectomized chicken develops scoliosis probably due to the lack of melatonin." | 3.75 | The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. ( Acaroglu, E; Akel, I; Alanay, A; Bozkurt, G; Kocak, O; Marcucio, R, 2009) |
| "The phenomenon of spinal deformity in the pinealectomized chicken has led researchers to postulate a disturbance of melatonin activity as a potential cause of adolescent idiopathic scoliosis (AIS)." | 3.75 | Pinealectomy in the chicken: a good model of scoliosis? ( Fagan, AB; Kennaway, DJ; Oakley, AP, 2009) |
| "To investigate the effect of melatonin on the colon inflammatory injury of rats with colitis and determine whether this effect is associated with inhibition of chemoattractant molecules interleukin (IL-8) and monocyte chemoattractant protein (MCP-1)." | 3.74 | Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. ( Li, HX; Li, JH; Liu, K; Wang, L; Zhou, W, 2008) |
| "This study tries to tests the hypothesis that "the intake of melatonin can minimize the morphological features of cell damage associated with radiation enteritis"." | 3.74 | Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model. ( Abdulwahed, SR; Abou El-Ghait, AT; Abu-Dief, EE; Ahmad, MH; Hussein, MR; Kamel, E, 2008) |
| " Since melatonin is a potent free radical scavenger and indirect antioxidant, the objective of this study was to evaluate whether melatonin administration would attenuate oxidative stress, brain edema, and neurological deficits in a rat model of ICH." | 3.74 | The antioxidant effects of melatonin after intracerebral hemorrhage in rats. ( Chen, W; Jadhav, V; Lekic, T; Martin, RD; Rojas, H; Tang, J; Titova, E; Zhang, J, 2008) |
| "The aim of this study was to compare the effects of mannitol and melatonin on brain edema secondary to trauma using magnetic resonance imaging (MRI)." | 3.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| "The results showed a trend in decreasing brain edema with lower doses of melatonin (5 mg/kg and 15 mg/ kg), however, high concentration of melatonin (150 mg/kg) significantly increased brain edema compared to all other groups." | 3.74 | The antioxidant effects of melatonin in surgical brain injury in rats. ( Ayer, R; Hyong, A; Jadhav, V; Lee, S; Lekic, T; Martin, R; Rojas, H; Stier, G; Zhang, JH, 2008) |
| "The aim of this study is to determine the effect of melatonin on intestinal anastomosis in the presence of peritonitis." | 3.74 | Effect of melatonin on healing of colonic anastomosis in a rat model of peritonitis. ( Başaklar, AC; Bukan, N; Demiroğullari, B; Ekingen, G; Kale, N; Karabulut, R; Ozen, IO; Sönmez, K; Taşlipinar, MY, 2007) |
| "To determine the antioxidant, antiinflammatory, and immunomodulatory effects of melatonin on endometrial explants, the distribution of cyclooxygenase-2 (COX-2), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and levels of malondialdehyde (MDA) in the rat endometriosis model." | 3.74 | Regression of endometrial explants in a rat model of endometriosis treated with melatonin. ( Güney, M; Karahan, N; Mungan, T; Oral, B, 2008) |
| "The study in ovariectomized (Ovx) rats, as a model of menopausal status, of the effects of melatonin (M) and/or estradiol (E), associated or not with food restriction, on body weight (BW) and serum leptin levels." | 3.74 | Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats. ( Alonso-Gonzalez, C; Cos, S; Gonzalez, A; Martinez-Campa, CM; Mediavilla, MD; Sanchez-Barcelo, EJ; Sanchez-Mateos, S, 2007) |
| " with normal saline in the control group (n = 21) and the asthma group (n = 22), melatonin in the melatonin group (n = 23), dexamethasone in the dexamethasone group (n = 24), and melatonin antagonist luzindole in the luzindole group (n = 7) respectively." | 3.74 | [The effect of melatonin on the regulation of collagen accumulation and matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 mRNA and protein in a murine model of chronic asthma]. ( Li, F; Liu, RY; Qian, ZX; Zhou, L, 2007) |
| " Compared with vehicle controls, melatonin therapy after hemorrhagic shock significantly improved plasma disappearance rate of indocyanine green, hepatic redox state, hepatocellular injury, and hepatic perfusion index." | 3.74 | Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Rensing, H; Waibel, L; Weiler, J; Wolf, B, 2008) |
| "Melatonin secretion decreased in fructose fed rats that developed hypertension." | 3.74 | The role of melatonin in the pathogenesis of hypertension in rats with metabolic syndrome. ( Grossman, E; Leibowitz, A; Peleg, E; Shabtai, Z; Shamiss, A; Sharabi, Y, 2008) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| "Melatonin attenuates the short-term consequences of brain ischemia in several animal models." | 3.74 | Chronic and acute melatonin effects in gerbil global forebrain ischemia: long-term neural and behavioral outcome. ( de Butte, M; Fréchette, M; Pappas, BA; Rennie, K, 2008) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 3.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "The current study was undertaken to determine whether melatonin therapy reverses vasospasm and prevents apoptosis by inhibiting lipid peroxidation in an experimental subarachnoid hemorrhage (SAH) model." | 3.73 | Effect of melatonin on cerebral vasospasm following experimental subarachnoid hemorrhage. ( Altinors, N; Atalay, B; Aydin, MV; Caner, H; Cekinmez, M; Ozen, O; Sen, O, 2005) |
| "The aim of this study was to evaluate the effects of melatonin on the inflammatory response and hydroxyproline production in an experimental acute and chronic model of trinitrobenzene sulfonic (TNBS) acid-induced colitis in Wistar rats." | 3.73 | Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. ( Calvo, JR; la de Lastra, CA; Marquez, E; Motilva, V; Sánchez-Fidalgo, S, 2006) |
| "To investigate whether a protein kinase C (PKC) inhibitor and melatonin prevent proliferative vitreoretinopathy (PVR)." | 3.73 | Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin. ( Er, H; Mizrak, B; Parlakpinar, H; Turkoz, Y, 2006) |
| "To observe ultrastructural changes and leptin expression in the guinea pig eye during experimental uveitis (EU) and the effects of vitamin E, melatonin and aprotinin on leptin expression." | 3.73 | Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitis. ( Alagöz, G; Celebi, S; Colakoğlu, N; Kükner, A; Kükner, AS; Serin, D, 2006) |
| "To determine the effects of melatonin combined with antibiotic administration on the suppression of renal scarring in an experimental pyelonephritis model." | 3.73 | Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis. ( Bahat, E; Cay, A; Cobanoglu, U; Imamoğlu, M; Karahan, C; Sarihan, H; Tosun, I, 2006) |
| "The 2[125I]iodomelatonin binding assay was used to investigate the involvement of melatonin receptors in the development of scoliosis in pinealectomized chickens." | 3.73 | Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. ( Cheung, KM; Leong, JC; Lu, DS; Poon, AM, 2006) |
| "Various evidences have documented that the pineal secretory product melatonin exerts an important anti-inflammatory effect in different experimental models including colitis." | 3.73 | Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. ( Crisafulli, C; Cuzzocrea, S; Di Bella, P; Esposito, E; Mazzon, E; Meli, R; Muià, C; Riccardi, L, 2006) |
| "To evaluate effects of melatonin on sodium selenite-induced cataract formation." | 3.73 | Use of melatonin to prevent selenite-induced cataract formation in rat eyes. ( Aydin, B; Durmuş, M; Erdurmuş, M; Gürel, A; Karadağ, R; Yağci, R; Yiğitoğlu, R, 2006) |
| "The cytokine profile during experimental esophagitis and modification of NO-NOS and prostaglandin activity and the melatonin administration has been investigated." | 3.73 | [The cytokine profile during experimental esophagitis and modification of cytoprotective mechanisms]. ( Bzhozovs'kyĭ, T; Hzhehots'kyĭ, MR; Konturek, SIa; Slivovs'kyĭ, Z; Zaiachkivs'ka, OS, 2006) |
| "The association between melatonin system and the spontaneous development of the spinal deformities in the Hereditary Lordoscoliotic Rabbit, the natural animal model for idiopathic scoliosis, was studied." | 3.72 | Implication for melatonin and its receptor in the spinal deformities of hereditary Lordoscoliotic Rabbits. ( Abe, M; Baba, I; Kanbara, K; Kin, A; Semoto, Y; Sobajima, S, 2003) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 3.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| " Methylprednisolone (MP), by reducing edema and protecting the cell membrane against peroxidation, is the only pharmacological agent with a proven clinically beneficial effect on SCI." | 3.72 | Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. ( Batcioglu, K; Cayli, SR; Erbil, M; Kocak, A; Ozturk, C; Tekiner, A; Yilmaz, U; Yologlu, S, 2004) |
| " In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis." | 3.72 | Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004) |
| "The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 3.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
| "The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determine the effects of melatonin and methylprednisolone on this oxidative stress." | 3.72 | Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. ( Aktan, B; Akyuz, M; Altas, E; Buyukokuroglu, ME; Ozabacigil, F; Ucuncu, H, 2004) |
| " The effects of 900 MHz of radiation on fibrosis, lipid peroxidation, and anti-oxidant enzymes and the ameliorating effects of melatonin (Mel) were evaluated in rat skin." | 3.72 | Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin. ( Akturk, O; Altuntas, I; Ayata, A; Mollaoglu, H; Ozguner, F; Yilmaz, HR, 2004) |
| "Our laboratory has demonstrated that treatment of MCF-7 breast cancer cells with melatonin (Mlt) followed 24h later with physiological concentrations of all-trans retinoic acid (atRA) results in apoptosis." | 3.71 | Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin. ( Anderson, MB; Bischoff, ED; Cheng, Q; Dai, J; Dwived, PD; Hill, SM; Kiefer, TL; Lai, L; Melancon, K; Moro, K; Nowfar, S; Teplitzky, SR; Yuan, L, 2002) |
| "Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth and an increase when relapse occurred." | 3.70 | Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion. ( Bartsch, C; Bartsch, H; Besenthal, I; Buchberger, A; Effenberger-Klein, A; Kruse-Jarres, JD; Mecke, D; Rokos, H; Stieglitz, A, 1999) |
| "A radiographic examination of pinealectomized rats to observe the development of scoliosis and halt the condition by administration of melatonin." | 3.70 | Pathogenesis of idiopathic scoliosis. Experimental study in rats. ( Dubousset, J; Kimura, J; Machida, M; Miyashita, Y; Murai, I; Yamada, T, 1999) |
| " The current study was designed to investigate the protective effect of melatonin, a radical scavenger and antioxidant, on non-septic shock induced by zymosan in the rat." | 3.70 | Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan. ( Caputi, AP; Cuzzocrea, S; El-Sokkary, GH; Hassanein, AF; Reiter, RJ; Tan, DX, 1999) |
| "The inability of retinal pigment epithelium to phagocytose shed photoreceptor disks is a cause of retinal degeneration in the Royal College of Surgeons rat; retinal pigment epithelial phagocytosis and disk shedding are regulated by the diurnal rhythm of retinal melatonin level." | 3.68 | Diurnal variations in the electroretinographic c-wave and retinal melatonin content in rats with inherited retinal dystrophy. ( Hawlina, M; Ikeda, H; Jenkins, HG, 1992) |
| " In communicating hydrocephalus, the function of the tela choroidae could be impaired by infectious or inflammatory processes; while in schizophrenia a physiologic disorder of cerebrospinal fluid production due to a melatonin deficiency may result in dilated ventricles." | 3.67 | The pathophysiology of enlarged ventricles in normal pressure communicating hydrocephalus and schizophrenia: a possible therapeutic role for melatonin. ( Maurizi, CP, 1987) |
| "Melatonin (MT) has been reported to control and prevent Alzheimer's disease (AD) in the clinic; however, the effect and mechanism of MT on AD have not been specifically described." | 2.82 | Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis. ( Qin, T; Sun, T; Xie, D; Xu, Y; Zhai, Z; Zhong, Y, 2022) |
| "Melatonin is a potent antioxidant and anti-inflammatory agent that is showing promising results in acute brain injury." | 2.72 | Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis. ( Chen, C; Hu, X; Hu, Z; Qin, H; Tang, J; Zeng, L; Zhu, Y, 2021) |
| "Pretreatment with melatonin was associated with a significant lower infarct size in comparison with vehicle in myocardial I/R damage (WMD: -20." | 2.66 | Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. ( Chen, YH; Huang, ZQ; Lin, H; Mao, ZJ; Xiao, FY, 2020) |
| "Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes." | 2.61 | The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish. ( Amstislavskaya, TG; Bashirzade, A; de Abreu, MS; Demin, KA; Dos Santos, BE; Genario, R; Giacomini, ACVV; Kalueff, AV; Marchiori, NI; Volgin, AD, 2019) |
| "Melatonin is a hormone that has been shown to have beneficial antioxidant and bone-metabolic effects." | 2.55 | Melatonin as a pro-osteogenic agent in oral implantology: a systematic review of histomorphometric outcomes in animals and quality evaluation using ARRIVE guidelines. ( Arora, H; Ivanovski, S, 2017) |
| "Melatonin has been found to modulate the learning and memory process in human as well as in animals." | 2.53 | The Potential Role of Melatonin on Memory Function: Lessons from Rodent Studies. ( Ahmad, AH; Othman, Z; Zakaria, R, 2016) |
| "Melatonin has been shown to be a versatile hormone having antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties." | 2.50 | Role of melatonin in traumatic brain injury and spinal cord injury. ( Naseem, M; Parvez, S, 2014) |
| "Bone resorption is reduced by increased synthesis of osteoprogeterin (OPG), a decoy receptor that prevents receptor activator of NK-κB ligand (RANKL) in binding to its receptor." | 2.49 | Melatonin and the skeleton. ( Amstrup, AK; Mosekilde, L; Rejnmark, L; Sikjaer, T, 2013) |
| "Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis." | 2.49 | Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. ( Chang, DM; Chen, SJ; Huang, SH; Lin, GJ; Sytwu, HK; Wang, CH, 2013) |
| "Obesity has become an epidemic in industrialized and developing countries." | 2.48 | Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. ( Korkmaz, A; Ma, S; Reiter, RJ; Tan, DX, 2012) |
| "Idiopathic scoliosis is a three-dimensional deformation of the spine." | 2.48 | Pathogenesis of idiopathic scoliosis: a review. ( Cugy, E; de Sèze, M, 2012) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 2.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "Melatonin is an endogenous indoleamine, produced mainly by the pineal gland." | 2.47 | Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. ( Amirian, I; Gögenur, I; Reiter, RJ; Rosenberg, J; Wilhelmsen, M, 2011) |
| "Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood." | 2.46 | Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010) |
| "Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity." | 2.46 | Hepatoprotective actions of melatonin: possible mediation by melatonin receptors. ( Mathes, AM, 2010) |
| "Melatonin is a hormone with indolaminic structure, produced in the pineal gland during darkness, with chronobiological activity that has been known for decades." | 2.44 | [Melatonina: old molecule, new medicament]. ( Fernández-Tresguerres Hernández, JA, 2008) |
| "Melatonin has a role in blood pressure regulation." | 2.44 | Melatonin as a potential antihypertensive treatment. ( Paulis, L; Simko, F, 2007) |
| "Evidence indicates that melatonin's anticancer effects are exerted via inhibition of cell proliferation and a stimulation of differentiation and apoptosis." | 2.43 | Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. ( Blask, DE; Dauchy, RT; Sauer, LA, 2005) |
| "Melatonin has been shown to prevent the progressive degeneration produced by neurotoxins employed in experimental models to mimic the degenerative events in various neuropsychiatric disease states." | 2.43 | The role of ML-23 and other melatonin analogues in the treatment and management of Parkinson's disease. ( Willis, GL, 2005) |
| "Melatonin is a neurohormone synthesized in the pineal gland during the dark period in all species, including humans." | 2.42 | Therapeutic perspectives for melatonin agonists and antagonists. ( Atkinson, J; Boutin, JA; Casteilla, L; Delagrange, P; Lesieur, D; Misslin, R; Pellissier, S; Pénicaud, L; Renard, P, 2003) |
| "Melatonin was recently reported to be an effective free radical scavenger and antioxidant." | 2.40 | Oxidative damage in the central nervous system: protection by melatonin. ( Reiter, RJ, 1998) |
| "Age-related macular degeneration is the leading cause of visual deficiency in older adults worldwide." | 1.91 | Melatonin protects retinal integrity through mediated immune homeostasis in the sodium iodate-induced mouse model of age-related macular degeneration. ( Cheng, HH; Ku, LC; Lai, DW; Lai, LC; Lee, CY; Lin, KH; Sheu, ML; Tsai, CY; Tsai, YC, 2023) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 1.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Oral squamous cell carcinomas are one of the most common cancers worldwide with aggressive behavior and poor prognosis." | 1.91 | Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS. ( Choi, WS; Li, X; Su, Y; Tao, Z; Wang, C; Wang, L; Zhu, W, 2023) |
| "Melatonin receptors have been reported to associate with aging and AD, and their expression decreased with the progression of AD." | 1.72 | Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model. ( Kim, J; Park, H, 2022) |
| " CP was given once intraperitoneally (10 mg/kg,) eliciting acute kidney injury as assured by several adverse histological changes; glomerulopathy, tubulopathy, and vasculopathy, an inflammatory response including elevated TNF-α, IL-6, and IL-1β." | 1.72 | TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone. ( Abd El-Emam, MM; Abdel-Rahman Mohamed, A; Bin Emran, T; El-Shetry, ES; Khater, SI; Metwally, MMM; Mostafa-Hedeab, G; Nassan, MA, 2022) |
| "Oral melatonin supplement has been shown to improve dermatitis severity in children with AD, but the mechanism of the effect is unclear, and it is uncertain whether melatonin has a direct immunomodulatory effect on the dermatitis." | 1.72 | Topical Melatonin Exerts Immunomodulatory Effect and Improves Dermatitis Severity in a Mouse Model of Atopic Dermatitis. ( Chang, YS; Chiang, BL; Tang, CY; Tsai, CC; Yang, PY, 2022) |
| "Melatonin levels were tested by ELISA." | 1.72 | Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2-mediated chromatin remodelling. ( Bian, X; Guo, J; Han, N; Hu, M; Jiang, H; Li, F; Li, X; Liu, C; Liu, G; Liu, X; Liu, Z; Wang, J; Wang, L; Wang, S; Wang, Y; Wei, X; Xie, Y; Zhang, H; Zhu, Z, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Melatonin is a neuroendocrine hormone mainly secreted by the pineal gland that plays an important role in the maintenance of the circadian rhythm and immunomodulation." | 1.72 | Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice. ( Cheng, B; Ding, Y; Liu, Y; Wei, M; Weng, X; Yu, S, 2022) |
| "Melatonin has been reported to suppress inflammation and alleviate liver fibrosis, but its effect on autophagy in liver fibrosis has not been studied." | 1.72 | Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy. ( Chen, W; Hong, RT; Jie, L; Ren, XF; Sha, LL; Zhang, YJ, 2022) |
| "Melatonin (MLT) plays a critical role in anti-inflammation, but the potential protective effect of melatonin on venous dysfunction induced by IVO has not been revealed." | 1.72 | Melatonin Alleviates Venous Dysfunction in a Mouse Model of Iliac Vein Occlusion. ( Du, X; Guo, Z; Lu, S; Ran, F; Xu, D; Xu, X; Zhou, Y, 2022) |
| "Sepsis is a life-threatening organ dysfunction." | 1.72 | Melatonin arrests excessive inflammatory response and apoptosis in lipopolysaccharide-damaged rat liver: A deeper insight into its mechanism of action. ( Lazarević, M; Milić, D; Mitić, K; Sokolović, D; Sokolović, DT; Stanojković, Z, 2022) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 1.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 1.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Melatonin treatment may have a therapeutic effect against sepsis since it prevents the increase in serum VEGF level." | 1.62 | Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis. ( Betül Tuncer, F; Boz, M; Çakıroğlu, H; Çokluk, E; Doğanay, S; Ramazan Şekeroğlu, M, 2021) |
| "Melatonin has been used in clinical anti-epileptic studies, but its effect on epileptic comorbidities is unknown, and the underlying mechanism needs further investigation." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "Melatonin (5 mg/kg) was injected i." | 1.62 | Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis. ( Bodard, S; Chalon, S; Favrais, G; Gressens, P; Gulhan, Z; Saliba, E; Savary, L, 2021) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 1.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| " MEL weakened the toxic effects of DOX on the cardiac tissue and it is shown histologically." | 1.62 | Effects of Melatonin and Adrenomedullin in Reducing the Cardiotoxic Effects of Doxorubicin in Rats. ( Bahceci, SA; Durdagi, G; Oyar, EO; Ozbek, M; Pehlivan, DY, 2021) |
| "Treatment with melatonin significantly alleviated neuronal apoptosis and accelerated the recovery of spinal cord function." | 1.62 | Role of melatonin in the dynamics of acute spinal cord injury in rats. ( Bi, J; Chen, C; Li, Z; Lin, Y; Shen, J; Sun, P; Tan, H, 2021) |
| "Melatonin (MT) has been used in clinical treatment for sleep disorders with only minor side effects." | 1.62 | Combined melatonin and adrenocorticotropic hormone treatment attenuates N-methyl-d-aspartate-induced infantile spasms in a rat model by regulating activation of the HPA axis. ( Li, Z; Shi, X; Sun, Y; Wan, L; Wang, J; Yang, G; Zhang, S, 2021) |
| "Melatonin was administrated either before or after the injection of 4TLM cells into the mammary pad." | 1.62 | Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer. ( Aytac, G; Dilmac, S; Karadas, AK; Tanriover, G, 2021) |
| "Melatonin (MT) is an indoleamine hormone that can counteract ischemia‑induced organ injury through its antioxidant effects." | 1.62 | Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway. ( Cai, QQ; Li, HW; Wu, XL; Yang, ZH; Ying, P, 2021) |
| "On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ." | 1.62 | Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021) |
| "Melatonin treatment led to a significant reduction in the degree of breast hyperplasia (P<0." | 1.62 | Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway. ( Huang, Y; Niu, Y; Zhang, X, 2021) |
| "The melatonin-treated animals had longer RR-intervals in the baseline state than the control animals (264 ± 48 ms versus 237 ± 33 ms, p = 0." | 1.62 | Melatonin pretreatment does not modify extrasystolic burden in the rat ischemia-reperfusion model. ( Azarov, JE; Bernikova, OG; Durkina, AV; Gonotkov, MA; Kuzmin, VS; Mikhaleva, NJ; Paderin, NM; Sedova, KA, 2021) |
| " The effects of these five neuromodulators on Alzheimer's disease (AD) are briefly examined in this paper, and it is hypothesized that each of the five molecules has a u-shaped (or Janus-faced) dose-response curve, wherein too little or too much signaling is pathological in AD and possibly other diseases." | 1.62 | Norepinephrine May Oppose Other Neuromodulators to Impact Alzheimer's Disease. ( Fitzgerald, PJ, 2021) |
| "Melatonin is a kind of hormone well known for its antioxidant properties, which has potential protective effects against diabetes mellitus and its complications." | 1.62 | Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway. ( Bao, M; Chen, M; Chen, R; Gao, F; Huang, D; Li, H; Li, J; Lu, B; Shi, G; Wang, B; Zhang, Y, 2021) |
| "Melatonin is an antioxidant; however, its role in MTX neuropathy is not well studied." | 1.56 | Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. ( Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC, 2020) |
| "Melatonin is a pleiotrophic hormone, synthesised primarily by the pineal gland under the control of the suprachiasmatic nuclei (SCN)." | 1.56 | Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease? ( Bawden, CS; Kuchel, TR; Middleton, B; Morton, AJ; Rudiger, S; Skene, DJ, 2020) |
| "Previous research demonstrated that sleep deprivation (SD) resulted in intestinal homeostasis disorder in colon." | 1.56 | Melatonin alleviates oxidative stress in sleep deprived mice: Involvement of small intestinal mucosa injury. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2020) |
| "Treatment with melatonin after Keto administration caused significant increases in FSH, LH, superoxide dismutase, total antioxidant capacity (TAC), sperm count, and sperm morphology but significant decreases in MDA and CRP, relative to groups 2 and 3." | 1.56 | Melatonin ameliorates some biochemical alterations following ketoconazole administration in rats. ( Abdul-Azeez, AR; Adeyemi, W; Alabi, Q; Okeleji, L; Olayaki, L; Omoniyi, J; Sampson, E; Shoyoye, A; Sulaiman, F, 2020) |
| "Treatment with melatonin rescued replicative senescence by enhancing mitophagy and mitochondrial function through upregulation of heat shock 70 kDa protein 1L (HSPA1L)." | 1.56 | Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. ( Lee, JH; Lee, SH; Noh, H; Song, KH; Yoon, YM, 2020) |
| "Endometriosis is now considered to be a public health problem that deserves in-depth investigation, especially the etiopathogenesis of endometriosis-associated infertility." | 1.56 | Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility. ( Dai, Y; Huang, D; Huang, Q; Jin, X; Li, C; Lin, X; Tong, X; Xu, W; Zhang, S; Zhou, F; Zhou, H, 2020) |
| "Microbial dysbiosis has long been postulated to be associated with the pathogenesis of inflammatory bowel disease (IBD)." | 1.56 | Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling. ( Cheon, JH; Kim, S; Kim, SW; Park, YS; Son, M, 2020) |
| "Melatonin has been demonstrated to ameliorate cardiac hypertrophy and its accompanied fibrosis in previous studies." | 1.56 | A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy. ( Cao, F; Lei, C; Liu, L; Wang, B; Wang, J; Wang, X; Yang, Q; Yuan, J; Zhang, J; Zhao, X; Zhu, X, 2020) |
| "Melatonin treatment significantly increased p-AMPK and OPA1 protein expression, whereas treatment with compound C ablated the observed benefits of melatonin treatment." | 1.56 | Melatonin Attenuates Calcium Deposition from Vascular Smooth Muscle Cells by Activating Mitochondrial Fusion and Mitophagy via an AMPK/OPA1 Signaling Pathway. ( Chen, WR; Liu, F; Sha, Y; Wu, XP; Yang, JQ; Zhou, YJ, 2020) |
| "CONCLUSIONS EA could alleviate the lung injury induced by limb ischemia-reperfusion by promoting the secretion of melatonin, while having no effect on the expression of melatonin receptor in lung tissues." | 1.56 | The Role of Melatonin in Electroacupuncture Alleviating Lung Injury Induced by Limb Ischemia-Reperfusion in Rabbits. ( Dong, SA; Gong, LR; Kan, YX; Yu, JB, 2020) |
| "Melatonin treatment caused a significant reduction in infarct size in hearts from both control and diet groups." | 1.56 | Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. ( Dhanabalan, K; Huisamen, B; Lochner, A; Mzezewa, S, 2020) |
| "Melatonin treatment also reduced sFlt-1, increased PlGF, and decreased the sFlt-1/PlGF ratio." | 1.56 | Melatonin attenuates hypertension and oxidative stress in a rat model of L-NAME-induced gestational hypertension. ( Jiang, Z; Zuo, J, 2020) |
| "Melatonin treatment for 8 weeks markedly attenuated cardiac hypertrophy and restored impaired cardiac function, as indicated by a decreased HW/BW ratio, reduced cell cross-sectional area and fibrosis, downregulated the mRNA levels of ANP, BNP, and β-MHC and ameliorated adverse effects on the LVEF and LVFS." | 1.56 | Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. ( Ding, P; Fan, ZG; Gao, EH; Kong, LH; Liu, Y; Xu, CN; Yang, J; Yang, LF, 2020) |
| "Melatonin has been successfully tested in experimental models in mice as a drug capable of reversing steatosis." | 1.56 | Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model. ( García, JJ; Gonzalo, A; Güemes, A; Martínez Soriano, B; Martínez-Beamonte, R; Navarro, AC; Osada, J; Palacios Gasós, P; Pola, G, 2020) |
| "Melatonin treatment significantly decreased infarct volume and cerebral apoptosis; mitigated endoplasmic reticulum stress and mitochondrial dysfunction; and inhibited CI/R injury-induced oxidative/nitrative stress and nuclear factor-κB activation, which was eradicated in RORα-deficient mice." | 1.56 | The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin. ( Ai, L; Gao, L; Gao, Y; Petersen, L; Pu, J; Qin, Z; Tong, R; Yan, Y; Zang, M; Zhao, Y; Zhong, F; Zhu, C, 2020) |
| "Multiple sclerosis is a progressive autoimmune disorder of the myelin sheath and is the most common inflammatory disease of young adults." | 1.56 | Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex. ( AboTaleb, HA; Alghamdi, BS, 2020) |
| "In this study, we tested several sleep deprivation protocols (mechanical shakes and light interruptions) on Drosophila and delineated their influences on Drosophila sleep." | 1.56 | Screening of sleep assisting drug candidates with a Drosophila model. ( Ma, WW; Peng, IF; Wang, YY, 2020) |
| "Melatonin treatment (3, 10 or 30 mg/kg, i." | 1.56 | Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice. ( Bobinski, F; Cunha, RA; Dafre, AL; de Menezes Moura, T; Fernandes, PA; Mack, JM; Markus, RP; Martins, DF; Prediger, RD; Walz, R, 2020) |
| "In recent decades, the occurrence of chronic obstructive pulmonary disease (COPD) has been increased remarkably in the population." | 1.56 | Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice. ( Dutta, S; Mahalanobish, S; Saha, S; Sil, PC, 2020) |
| "Melatonin treatment resulted in reduced numbers of both osteoblasts and osteoclasts in the fractured scale." | 1.56 | Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale. ( Hattori, A; Kobayashi, I; Kobayashi-Sun, J; Suzuki, N; Yamaguchi, M, 2020) |
| "Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors." | 1.56 | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder. ( Block, GD; Colwell, CS; Ghiani, CA; Hitchcock, ON; In Kim, Y; Kim, YS; Loh, DH; Luk, SHC; MacDowell Kaswan, ZA; Tahara, Y; Wang, HB, 2020) |
| "Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function." | 1.56 | Cyst Reduction by Melatonin in a Novel ( Gamberi, C; Millet-Boureima, C; Polyak, F; Rozencwaig, R, 2020) |
| "Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction." | 1.56 | A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma. ( Amato, R; Bagnoli, P; Cammalleri, M; Corsaro, R; Dal Monte, M; Pezzino, S; Rusciano, D, 2020) |
| "Melatonin was also administered with tap water at 6 g/L ad libitum for 6 weeks; the animals were then euthanized for immunohistochemistry with Ki67, doublecortin (DCX), glucose transporter 3 (GLUT3), and phosphorylation of cyclic adenosine monophosphate (AMP) response element binding (pCREB); double immunofluorescence of neuronal nuclei (NeuN) and myelin basic protein (MBP); and Western blot analysis of brain-derived neurotrophic factor (BDNF) expression to reveal the effects of cuprizone and melatonin on cell damage and hippocampal neurogenesis." | 1.51 | Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus. ( Hahn, KR; Hwang, IK; Jung, HY; Kim, DW; Kim, JW; Kim, W; Kwon, HJ; Nam, SM; Park, JH; Won, MH; Yoo, DY; Yoon, YS, 2019) |
| "By day 28 after IS, the brain infarct area (BIA) was lowest in group 1, highest in group 2, significantly higher in groups 3 and 4 than in group 5, but not different between groups 3 and 4." | 1.51 | Combined Therapy With Hyperbaric Oxygen and Melatonin Effectively Reduce Brain Infarct Volume and Preserve Neurological Function After Acute Ischemic Infarct in Rat. ( Chen, KH; Chen, YL; Ko, SF; Lee, MS; Lin, KC; Wallace, CG; Yip, HK, 2019) |
| "Glaucoma is a multifactorial neurodegenerative disorder and one of the leading causes of irreversible blindness globally and for which intraocular pressure is the only modifiable risk factor." | 1.51 | Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma. ( Arranz-Romera, A; Bravo-Osuna, I; Cordeiro, MF; Davis, BM; Esteban-Pérez, S; Guo, L; Herrero-Vanrell, R; Molina-Martínez, IT; Ravindran, N; Shamsher, E, 2019) |
| "Severe acute pancreatitis is associated with high morbidity and mortality." | 1.51 | Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. ( Bachmann, K; Erbes, J; Gocht, A; Grupp, K; Havel, J; Izbicki, JR; Mann, O; Poppe, A; Trepte, C; Wodack, K, 2019) |
| "Melatonin has been shown to decrease the toxic effects of cisplatin due to its antioxidant activity, and could increase the efficacy of cancer chemotherapy." | 1.51 | Protective Effect of Melatonin on Cisplatin-induced Ototoxicity in Rats. ( DE Araujo, JG; Kückelhaus, SAS; Lauand, L; Sampaio, ALL; Serra, LSM, 2019) |
| "Docetaxel (DTX) has been used in cancer treatments for several decades, but it results in many adverse apoptotic effects through excessive production of reactive oxygen species (ROS) in some tissue including the kidney and testes." | 1.51 | Treatment with melatonin and selenium attenuates docetaxel-induced apoptosis and oxidative injury in kidney and testes of mice. ( Baş, E; Nazıroğlu, M, 2019) |
| "This study investigated the ameliorative role of melatonin (MLT) and the effects of a long-term intake of high-fructose corn syrup (HFCS) on the male reproductive system." | 1.51 | The effects of high-fructose corn syrup consumption on testis physiopathology-The ameliorative role of melatonin. ( Aslankoc, R; Ozmen, O, 2019) |
| "Melatonin has been shown to reduce oxidative stress and mitigate hypercoagulability." | 1.51 | Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model. ( Burd, I; Dong, J; Jia, B; Jones-Beatty, K; Lee, JY; Lei, J; Li, S; McLane, MW; Na, Q; Ozen, M; Shin, NE, 2019) |
| "Melatonin treatment inhibited peripheral tissue inflammation and tissue damage in a cecal ligation puncture (CLP)-induced polymicrobial sepsis model, consequently reducing the mortality of the mice." | 1.51 | Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils. ( Jin, JO; Kwak, M; Lee, PCW; Xu, L; Zhang, L; Zhang, W, 2019) |
| "Treatment with melatonin significantly reversed these abnormalities." | 1.48 | Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model. ( Fujikura, T; Ishigaki, S; Isobe, S; Iwakura, T; Kato, A; Matsuyama, T; Miyajima, H; Ohashi, N; Tsuji, N; Tsuji, T; Yasuda, H, 2018) |
| "Melatonin was administered 1, 24, 48 and 72 h after TBI through i." | 1.48 | Does the administration of melatonin during post-traumatic brain injury affect cytokine levels? ( Asadikorom, G; Dehghan, F; Khaksari, M; Najafi, A; Shahrokhi, N; Soltani, Z, 2018) |
| "Melatonin (Mel) was administered to ameliorate the sleep-awake rhythm (CCI-free + Mel and CCI-misaligned + Mel)." | 1.48 | Misaligned Feeding May Aggravate Pain by Disruption of Sleep-Awake Rhythm. ( Chu, S; Gong, X; Gu, X; Liu, H; Ma, Z; Shao, X; Xu, F; Zhao, X, 2018) |
| "Melatonin (50mg/kg) was additionally administered to one group for the 30days of the experiment." | 1.48 | Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen. ( Charoensuk, L; Dangtakot, R; Intuyod, K; Pinlaor, P; Pinlaor, S; Wongsena, W, 2018) |
| "Nitric oxide is implicated in hepatic encephalopathy and is also involved in cognition." | 1.48 | Melatonin prevented spatial deficits and increases in brain asymmetric dimethylarginine in young bile duct ligation rats. ( Chen, YC; Hsu, MH; Huang, LT; Li, SW; Sheen, JM, 2018) |
| "Melatonin treatment prevented LPS-induced depressive-like behavior in the forced swim and tail suspension tests with no alterations in locomotor activity evaluated in the open field test." | 1.48 | Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice. ( Buss, ZS; Doneda, DL; Ferreira, YS; Fraga-Junior, EB; Lima, E; Lopes, L; Mendonça, CB; Rossi, FL; Stupp, IJV; Taniguti, EH; Vandresen-Filho, S; Ynoue, HN, 2018) |
| "Melatonin is an effective treatment in MS patients and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS." | 1.48 | Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis. ( Farhadi, N; Ghareghani, M; Sadeghi, H; Zibara, K, 2018) |
| "Melatonin induced lower IP3R and higher SERCA2a expression in myocardium that were reversed by PD98059." | 1.48 | Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1. ( Chen, Y; Hu, S; Zhang, Y; Zhou, H; Zhu, P, 2018) |
| "Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health." | 1.48 | Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. ( Ding, S; Fang, J; Jiang, H; Ma, Y; Zhu, D, 2018) |
| "Treatment with melatonin significantly increased OPN and SMP30 expression and ACh, NE, and Dop levels in the hippocampus with amelioration of the oxidative stress compared with BCCAO rats." | 1.48 | Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia. ( Bin-Jaliah, I; Sakr, HF, 2018) |
| "Melatonin, which is an antioxidant and neuroprotective agent, can be an effective treatment for neurological disorders." | 1.48 | Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation. ( Azizi, M; Kashani, IR; Mokhtari, T; Nadji, SA; Omidi, N; Pasbakhsh, P; Pourabdollah, M; Sadr, M; Zendehdel, A, 2018) |
| " We examined whether maternal melatonin therapy can prevent maternal high-fructose combined with post-weaning high-salt diet-induced programmed hypertension in adult offspring." | 1.48 | Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. ( Chan, JYH; Lee, WC; Leu, S; Tain, YL; Wu, KLH, 2018) |
| "Melatonin is a well-known potent endogenous antioxidant pharmacological agent with significant neuroprotective actions." | 1.48 | Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain. ( Ali, T; Kim, MO; Rehman, SU; Shah, FA, 2018) |
| "Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated." | 1.48 | Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus. ( Baka, M; Turgut, M; Uyanıkgil, Y, 2018) |
| "Melatonin (MTG) plays critical roles in circadian rhythm disorders, Alzheimer's disease, and other neurological disorders." | 1.48 | Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder. ( Hahm, DH; Lee, B; Lee, H; Shim, I, 2018) |
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 1.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "Rotenone is a frequently used neurotoxin in developing a PD model to aid in understanding the mechanisms of neuronal death." | 1.48 | Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease. ( Andrabi, SS; Parveen, S; Parvez, S; Rasheed, MZ; Salman, M; Shaquiquzzaman, M; Tabassum, H, 2018) |
| "Cerebral injury after cardiac arrest (CA)/cardiopulmonary resuscitation (CPR) has been implicated in the poor prognosis of CA survivors." | 1.48 | Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest. ( Chen, Q; Deng, Y; Gong, C; Hai, K; Jiang, C; Li, H; Li, Q; Li, T; Wang, J; Wu, W; Yang, L; Zhou, R, 2018) |
| "Letrozole was administered orally (1 mg kg-1) to induce PCOS condition in Wistar female rats for a period of 2-3 weeks followed by a dose of melatonin (200 µg/100 g b." | 1.48 | Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat. ( Ahmad Hajam, Y; Basheer, M; Ghosh, H; Rai, S, 2018) |
| "Melatonin treatment also significantly increased the GAP43 in the cortex." | 1.46 | Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury. ( Fang, M; Hu, Y; Jiang, H; Li, Z; Lin, Z; Liu, Y; Pan, S; Wang, Z; Xiao, J; Yin, J; Zhang, H; Zou, S, 2017) |
| "Melatonin was injected intraperitoneally 1 h before lipopolysaccharide injection and then once a day for 1 week to evaluate the long-term effects." | 1.46 | Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats. ( Fang, M; Gao, Z; Hu, Y; Jiang, H; Li, Z; Lin, Z; Pan, S; Wang, Z; Xiao, J; Xu, K; Zhang, H, 2017) |
| "By assessing oral squamous cell carcinoma (OSCC) tissue arrays through immunohistochemistry, we examined whether aberrant LSD1 overexpression in OSCC is associated with poor prognosis." | 1.46 | Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. ( Chen, YW; Hsieh, CC; Lin, CK; Lin, GJ; Ma, KH; Shieh, YS; Sytwu, HK; Tsao, CH; Yang, CY, 2017) |
| "Atopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease." | 1.46 | Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models. ( Kim, YU; Lee, SH; Oh, DS; Park, G, 2017) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 1.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| "Neuropathic pain is a severe condition with unsatisfactory treatments." | 1.46 | Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats. ( Bonazza, V; Borsani, E; Buffoli, B; Reiter, RJ; Rezzani, R; Rodella, LF, 2017) |
| "Melatonin (80 mg/kg) was given intraperitoneally 15 min before the seizure." | 1.46 | Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model. ( Aydin, L; Korkmaz, Y; Ogus, E; Sezer, T; Yurtcu, E, 2017) |
| "Hydrocephalus is a developmental disorder causing abnormally collected cerebrospinal fluid within the cerebral ventricles." | 1.46 | Effects of Melatonin on the Cerebellum of Infant Rat Following Kaolin-Induced Hydrocephalus: a Histochemical and Immunohistochemical Study. ( Baka, M; Turgut, M; Uyanıkgil, Y, 2017) |
| "Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone-refractory stages." | 1.46 | IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer. ( Cepas, V; Gonzalez-Menendez, P; Gonzalez-Pola, I; Hevia, D; Mayo, JC; Quiros-Gonzalez, I; Rodriguez-Garcia, A; Sainz, RM, 2017) |
| "Melatonin treatment effectively ameliorated MI/R injury by reducing infarct size, myocardial apoptosis, and oxidative stress." | 1.46 | Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner. ( Fan, C; Li, Z; Wang, H; Xu, Y; Xue, X; Yang, Y; Yu, L; Zhang, J; Zhao, G, 2017) |
| "Melatonin has been demonstrated to have anti-inflammatory and antioxidant effects." | 1.46 | Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway. ( He, X; Huang, H; Liu, W; Wang, J; Wei, Z; Yang, Z; Zhang, J; Zhang, Y, 2017) |
| "Melatonin plays a crucial role in regulating diverse physiological functions and metabolic homeostasis." | 1.46 | Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression. ( Chung, MJ; Elfadl, AK; Harris, RA; Hwang, SL; Jeong, KS; Kim, HM; Kim, YD; Lee, EJ; Lee, SE; Nedumaran, B, 2017) |
| " A total of 20 landrace pigs were randomized to a dosage of 200 mg (0." | 1.43 | Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction. ( Aarøe, J; Ekeløf, SV; Gögenur, I; Halladin, NL; Jensen, SE; Kjærgaard, B; Rosenberg, J; Simonsen, CW; Zaremba, T, 2016) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 1.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Melatonin treatment of the chick embryo starting at day 13 of incubation, equivalent to ca." | 1.43 | Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo. ( Beck, C; Giussani, DA; Itani, N; Niu, Y; Skeffington, KL, 2016) |
| "Treatment with melatonin eliminated the deleterious effect of HSD in the kidneys of Dahl salt-sensitive rats." | 1.43 | Melatonin prevents kidney injury in a high salt diet-induced hypertension model by decreasing oxidative stress. ( Barshack, I; Grossman, E; Leibowitz, A; Shemesh, C; Volkov, A; Voloshin, K, 2016) |
| "Melatonin treatment did not show a protective effect on neuronal metabolism." | 1.43 | No improvement of neuronal metabolism in the reperfusion phase with melatonin treatment after hypoxic-ischemic brain injury in the neonatal rat. ( Berger, HR; Brubakk, AM; Morken, TS; Sonnewald, U; Vettukattil, R; Widerøe, M, 2016) |
| "Melatonin (Mel) is an indoleamine displaying several anti-cancer properties and has been reported to modulate apoptosis signaling in multiple tumor subtypes." | 1.43 | Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. ( Alves, MS; Camargo, IC; Chuffa, LG; Domeniconi, RF; Júnior, LA; Martinez, FE; Martinez, M; Pinheiro, PF, 2016) |
| "Melatonin is supposed to be an effective hepatoprotective agent." | 1.43 | Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats. ( Chen, H; Jang, L; Li, Z; Rui, BB; Wei, W; Xu, WP; Yang, JM, 2016) |
| "Melatonin treatment with either dose reversed the aging-derived inflammation (p<0." | 1.43 | Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. ( Carrasco, A; Escames, G; Paredes, SD; Puig, Á; Rancan, L; Tresguerres, JA; Vara, E, 2016) |
| "Melatonin was administrated to rats intraperitoneally (30 mg/kg)." | 1.43 | Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism. ( An, R; Li, H; Liu, H; Shen, G; Sun, L; Xi, C; Zhang, S; Zhao, L, 2016) |
| "Melatonin treatment attenuated the decrease in tyrosine hydroxylase in the striatum and abolished it in the substantia nigra." | 1.43 | Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson's disease. ( Carriere, CH; Kang, NH; Niles, LP, 2016) |
| "Colitis was induced by intracolonic (i." | 1.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD)." | 1.43 | Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease. ( Aleksic, M; Favero, G; Golic, I; Korac, A; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A, 2016) |
| "Melatonin was administered orally at 2." | 1.43 | Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. ( Hong, JM; Kang, JW; Lee, SM, 2016) |
| "Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions." | 1.43 | Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. ( Gao, GF; Grailer, JJ; Li, X; Tan, DX; Wang, M; Wang, N; Ward, PA; Yao, J; Zhang, Y; Zhong, R, 2016) |
| "Treatment with melatonin at 4 mM significantly attenuated the sleep problems and rescued the reduction in mEPSC and EPSP frequency in the hLRRK2 transgenic flies." | 1.43 | Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease. ( Chen, L; Gu, H; Guo, W; Huang, Y; Liang, F; Long, S; Lu, X; Nucifora, FC; Pei, Z; Ran, D; Ross, CA; Sun, X; Zeng, J; Zhao, X, 2016) |
| "Melatonin has been considered a robust anti‑oxidant, and is able to attenuate DN in several animal models." | 1.43 | Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model. ( Ji, ZZ; Xu, YC, 2016) |
| "Melatonin treatment was administered 24 hours prior to Aβ1-42 administration via an intraperitoneal injection." | 1.43 | Protective effect of melatonin on soluble Aβ1-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus. ( Bi, J; Hu, C; Ren, L; Wang, P; Zhang, S, 2016) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 1.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala." | 1.42 | Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. ( Furuse, M; Goda, R; Iwamoto, A; Kawai, M; Matsuo, H; Nagasawa, M; Nagy, AD; Otsuka, T; Yasuo, S, 2015) |
| "Melatonin (mel) acts as an anti-inflammatory factor and has been reported to modulate TLRs in some aggressive tumor cell types." | 1.42 | Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer. ( Chuffa, LG; Delazari Dos Santos, L; Domeniconi, RF; Fávaro, WJ; Ferreira Seiva, FR; Fioruci-Fontanelli, BA; Martinez, FE; Martinez, M; Mendes, LO; Pinheiro, PF, 2015) |
| "Melatonin plays a protective role in type 2 diabetes (T2D) through regulation of glucose metabolism." | 1.42 | Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats. ( Li, S; McCabe, MF; Rong, P; Wang, S; Wang, X; Zhai, X, 2015) |
| "Melatonin pretreatment of the AlCl3 -administered rats reduced brain damage, and the tissues appeared like those of the control rats." | 1.42 | The protective properties of melatonin against aluminium-induced neuronal injury. ( Abdel Moneim, AE; Al-Olayan, EM; El-Khadragy, MF, 2015) |
| "Translational research on Alzheimer's disease (AD) has often focused on reducing the high cerebral levels of amyloid-β (Aβ) as a key characteristic of AD pathogenesis." | 1.42 | Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology. ( Kiseleva, E; Kolosova, NG; Maksimova, KY; Muraleva, NA; Rudnitskaya, EA; Stefanova, NA, 2015) |
| "Melatonin is an endogenous synchronizer of biological rhythms and a modulator of physiological functions and behaviors of all mammals." | 1.42 | Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption. ( Noori, HR; Spanagel, R; Vengeliene, V, 2015) |
| "Melatonin has strong antioxidant and anti-inflammatory effects that help to restore body's immune and cognitive functions." | 1.42 | The potential role of melatonin on sleep deprivation-induced cognitive impairments: implication of FMRP on cognitive function. ( Choi, YY; Han, SH; Jeon, SJ; Kim, MK; Kwon, KJ; Lee, EJ; Shin, CY, 2015) |
| "Melatonin has been demonstrated to reduce liver damage in different models of stress." | 1.42 | Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis. ( Abend, M; Fink, T; Glas, M; Kleber, A; Mathes, AM; Ruf, CG; Volk, T; Wolf, A; Wolf, B, 2015) |
| "Similarly, amyloid plaque loads in hippocampus and frontal cortex, as well as plasma Aβ1-42 levels, were significantly reduced by MEL in a receptor-independent manner, in contrast to MEL's efficacy in reducing cortical antioxidant gene expression (Catalase, SOD1, Glutathione Peroxidase-1, Nrf2) only when receptors were present." | 1.42 | Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. ( Bradshaw, PC; Delic, V; O'Neal-Moffitt, G; Olcese, J, 2015) |
| "Melatonin has been previously reported to provide neuroprotective effects in in vivo models of stroke by a mechanism that implicates melatonin receptors." | 1.42 | Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. ( Buendia, I; Egea, J; Gameiro, I; Gómez-Rangel, V; González-Lafuente, L; Laudon, M; León, R; López, MG; Michalska, P; Parada, E, 2015) |
| "Melatonin is a multifunctional molecule and plays a crucial role in the regulation of circadian rhythms." | 1.42 | Melatonin Attenuates Memory Impairment, Amyloid-β Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer's Disease. ( Kiseleva, E; Kolosova, NG; Maksimova, KY; Muraleva, NA; Rudnitskaya, EA; Stefanova, NA, 2015) |
| "Melatonin is a highly potent free radical scavenger that protects against ischemic stroke." | 1.42 | Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation. ( Beker, MC; Caglayan, AB; Caglayan, B; Hermann, DM; Kelestemur, T; Kilic, E; Kilic, U; Yalcin, E; Yulug, B, 2015) |
| "The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps." | 1.42 | Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015) |
| "Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice." | 1.40 | The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. ( Acuña-Castroviejo, D; Doerrier, C; Escames, G; García, JA; López, A; López, LC; Luna-Sánchez, M; Ortiz, F; Venegas, C; Volt, H, 2014) |
| "For this purpose, preterm labor was induced in BALB/c mice by intraperitoneal injections of bacterial lipopolysaccharide (LPS) at 10." | 1.40 | Melatonin prevents experimental preterm labor and increases offspring survival. ( Aisemberg, J; Bariani, MV; Cella, M; Domínguez Rubio, AP; Franchi, AM; Rosenstein, RE; Salazar, AI; Sordelli, MS, 2014) |
| "Melatonin has been considered a potent antioxidant that detoxifies a variety of reactive oxygen species in many pathophysiological states of eye." | 1.40 | Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats. ( Doğan, S; Kahya, MC; Nazıroğlu, M; Tök, L; Tök, O, 2014) |
| "It contributes to the development of acute renal failure." | 1.40 | Effect of a combined treatment with erythropoietin and melatonin on renal ischemia reperfusion injury in male rats. ( Ahmadiasl, N; Alihemati, A; Azimian, E; Banaei, S; Baradaran, B, 2014) |
| "Melatonin treatment also resulted in decreased immunoreactivity for RHDV viral VP60 antigen and a significantly reduction in RHDV VP60 mRNA levels, oxidized to reduced glutathione ratio (GSSG/GSH), caspase-3 activity, and immunoglobulin-heavy-chain-binding protein (BiP) and CCAAT/enhancer-binding protein homologous protein (CHOP) expression." | 1.40 | Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus. ( Álvarez, M; Crespo, I; González-Gallego, J; Prieto, J; San-Miguel, B; Tuñón, MJ; Vallejo, D, 2014) |
| "Melatonin treatment significantly reduced LPS-induced neurobehavioral disturbances and brain damage in neonatal rats." | 1.40 | Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats. ( Fan, LW; Jow, GM; Kaizaki, A; Tien, LT; Wong, CS, 2014) |
| "Rats treated with melatonin had higher bone volume, bone trabecular number, trabecular thickness, and cortical thickness in comparison to the control group." | 1.40 | Melatonin dietary supplement as an anti-aging therapy for age-related bone loss. ( Barralet, JE; Calvo-Guirado, JL; Eimar, H; Prieto, S; Tamimi, F; Torres, J; Tresguerres, IF; Tresguerres, JA, 2014) |
| "A mouse model of chronic neuropathic pain induced by partial sciatic nerve ligation (PSL) was employed." | 1.40 | Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. ( Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D, 2014) |
| "Melatonin treatment following photochemically induced SCI in rats significantly ameliorated the functional deficits." | 1.40 | Melatonin improves functional outcome via inhibition of matrix metalloproteinases-9 after photothrombotic spinal cord injury in rats. ( Hur, H; Jang, JW; Kim, HS; Lee, JK; Lee, SS; Piao, MS; Xiao, L, 2014) |
| "Melatonin treatment (similar to lithium) was also effective in preventing the following alterations elicited by OUA: increase of RS and PC levels; depletion of NPSH levels; increase of SOD activity; and inhibition of CAT and GPx activities." | 1.40 | The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain. ( Boeira, SP; Bortolatto, CF; Jesse, CR; Nogueira, CW; Souza, LC; Wilhelm, EA, 2014) |
| "In melatonin treated rats, prefrontal tissue malondialdehyde and protein carbonyl levels were decreased significantly in comparison with MK-801 group (p < 0." | 1.40 | Potential role of some oxidant/antioxidant status parameters in prefrontal cortex of rat brain in an experimental psychosis model and the protective effects of melatonin. ( Akyol, O; Kus, I; Ozyurt, B; Ozyurt, H; Sarsilmaz, M; Songur, A, 2014) |
| "Melatonin was shown to decrease the level of mRNA for AhR-dependent genes of CYP1A2 and CYP1B1 cytochromes in the retina, but had no effect on the content of mRNA for Nrf2-dependent genes in OXYS rats." | 1.40 | Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process. ( Grishanova, AY; Perepechaeva, ML; Stefanova, NA, 2014) |
| "Procarbazine (P) is an effective chemotherapeutic drug especially used in lymphoma treatment; however testicular toxicity is a limiting factor." | 1.40 | The effect of melatonin on procarbazine induced testicular toxicity on rats. ( Akgül, EÖ; Alp, BF; Babacan, O; Erdem, O; Gulgun, M; Kesik, V; Korkmazer, N; Malkoç, E; Poyrazoglu, Y; Saldır, M; Yiğit, N, 2014) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 1.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Pravastatin was given orally (1 00 mg/kg) and melatonin was added to the water (20 μg/ml)." | 1.40 | Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model. ( Adamicová, K; Adamkov, M; Bojková, B; Chmelová, M; Kajo, K; Kapinová, A; Kassayová, M; Kružliak, P; Kubatka, P; Orendáš, P; Péč, M; Sadloňová, V; Stollárová, N; Výbohová, D, 2014) |
| "Treatment with melatonin resulted in significant attenuations of oxidative damage, a decrease in the GSH/GSSG ratio, and a significant amelioration of memory impairment in this aging model." | 1.40 | Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. ( Chung, YH; Dang, DK; Jeong, JH; Kim, HC; Le, HL; Nabeshima, T; Nabeshima, Y; Nah, SY; Nam, Y; Shin, EJ; Wie, MB, 2014) |
| "The current therapies for Alzheimer's disease (AD) are merely palliative that cannot arrest the pathologic progression of the disease." | 1.39 | Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. ( Hong, XP; Hu, J; Liu, D; Peng, CX; Wang, JZ; Wu, YY; Zhu, LQ, 2013) |
| "The purpose of the study was to assess whether it is possible to reduce the oxidative damage using antioxidant agents combined with hormone replacement therapy after menopause." | 1.39 | Effects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized rats. ( Ay, A; Ay, AA; Dost, T; Kafkas, S; Turgut, H; Turgut, O, 2013) |
| "Reflux esophagitis is a common clinical entity in western countries with approximately 30% of the population experiencing the symptoms at least once every month." | 1.39 | Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis. ( Brzozowska, I; Brzozowski, T; Hess, T; Kania, J; Konturek, PC; Konturek, SJ; Kwiecien, S; Pawlik, M; Reiter, RJ; Targosz, A, 2013) |
| "Melatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration." | 1.39 | Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats. ( Akman, S; Canakci, CF; Kalkan, Y; Kara, A; Ozkanlar, S; Tozoglu, S; Tozoglu, U, 2013) |
| "Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models." | 1.39 | Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. ( Andorka, C; Bainbridge, A; Cady, EB; Chandrasekaran, M; Faulkner, S; Fleiss, B; Golay, X; Gressens, P; Hristova, M; Lecky-Thompson, L; Powell, E; Price, D; Raivich, G; Robertson, NJ; Thei, L, 2013) |
| "Melatonin-treated rats received daily melatonin 1 mg/kg/d via i." | 1.39 | Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C. ( Chen, CC; Huang, LT; Kao, YH; Lee, CT; Sheen, JM; Tain, YL; Yu, HR, 2013) |
| "Melatonin was partially effective against the inhibition of striatal catalase activity and a decrease of non-protein thiol levels induced by quinolinic acid." | 1.39 | Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington's disease: protective effect of melatonin. ( Antunes Wilhelm, E; Folharini Bortolatto, C; Ricardo Jesse, C; Wayne Nogueira, C, 2013) |
| "Melatonin treatment improved spatial learning and memory and increased the number of choline acetyltransferase (ChAT)-positive cells in the medial septum of both TS and CO mice." | 1.39 | Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. ( Corrales, A; Flórez, J; García, E; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sanchez-Barceló, EJ; Vidal, V, 2013) |
| "Melatonin has diverse physiological actions in addition to its well-recognized maintenance roles in circadian and seasonal timing." | 1.38 | Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia. ( Castillo-Melendez, M; Jenkin, G; Miller, SL; Walker, DW; Wallace, EM; Yawno, T, 2012) |
| "The melatonin treatment resulted in increased hind-limb motor function and decreased iNOS mRNA expression in the L/D condition compared with the LL condition (P < 0." | 1.38 | Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury. ( Chang, KT; Hong, Y; Jeon, JC; Kim, JH; Lee, S; Lee, SK; Lee, SR; Lee, Y; Park, K; Park, S, 2012) |
| "Previous studies in rat models of hemorrhagic shock have suggested a benefit." | 1.38 | Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock. ( Beilman, GJ; Greenberg, JJ; Lexcen, DR; Luzcek, E; Mulier, KE, 2012) |
| "Melatonin has ubiquitous actions, both as a direct free-radical scavenger and as an indirect anti-oxidant." | 1.38 | Neuroprotective effects of melatonin on the nigrostriatal dopamine system in the zitter rat. ( Ehara, A; Hashimoto, K; Hirata, K; Sakakibara, S; Ueda, S; Yoshimoto, K, 2012) |
| "Melatonin was effective against the immunosenescence that 3xTg-AD mice present." | 1.38 | Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. ( Acuña-Castroviejo, D; Cristòfol, R; Escames, G; García-Mesa, Y; Giménez-Llort, L; López, LC; Sanfeliu, C; Venegas, C, 2012) |
| "Melatonin was also applied before hypoxia to influence free radical (FR) production and intrinsic antioxidant activation." | 1.38 | An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin. ( Deykun, K; Krýsl, D; Mareš, J; Pometlová, M; Rokyta, R, 2012) |
| "Melatonin also reduced reactive gliosis." | 1.38 | Histological study of the protective effect of melatonin on neural cells after neonatal hypoxia-ischemia. ( Alonso-Alconada, D; Alvarez, A; Hilario, E; Lacalle, J, 2012) |
| "Melatonin pretreatment prior to liver I/R can effectively reduce the pulmonary microvascular permeability and attenuate lipid peroxidation in the lungs." | 1.38 | Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats. ( Chen, CF; Chen, KH; Chiu, MH; Su, CL; Wang, D; Wang, JJ, 2012) |
| "Melatonin pretreatment also protected the liver against I/R injury (P < ." | 1.38 | Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs. ( Chen, CF; Su, CL; Wang, D; Wang, JJ; Yeh, JH, 2012) |
| "Melatonin pretreatment effectively scavenged oxidants and hydroxyl radicals, protecting cardiac function against liver I/R-induced injury." | 1.38 | Preischemic treatment with melatonin attenuates liver reperfusion-induced impairment of cardiac function. ( Chen, KH; Chen, TH; Wang, JJ, 2012) |
| "Melatonin has anti-oxidant activity and it exerts a neuroprotective effects during ischemic brain injury." | 1.38 | Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury. ( Koh, PO, 2012) |
| "Melatonin has antioxidant and neuroprotective properties in human beings and experimental models, as well as 'anti-estrogenic' effects." | 1.38 | Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice. ( Cutrera, RA; Karadayian, AG; Mac Laughlin, MA, 2012) |
| "Melatonin treatment significantly attenuated MMP-9 activity and expression at 24, 48, and 72 h after ischemic injury." | 1.38 | Melatonin reduced the elevated matrix metalloproteinase-9 level in a rat photothrombotic stroke model. ( Jang, JW; Kim, HS; Kim, SH; Lee, JK; Lee, MC; Piao, MS, 2012) |
| "Melatonin caused the increase in the pain threshold of the mechanical allodynia and the slight increase in the threshold of the thermal hyperalgesia." | 1.38 | Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| " Owing to aldose reductase pharmacophore requirements for an acidic proton, most aldose reductase inhibitors contain an acetic acid moiety, ionized at physiological pH, resulting in poor bioavailability of the drugs." | 1.37 | (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature. ( Juskova, M; Milackova, I; Snirc, V; Stefek, M; Triantos, N; Tsantili-Kakoulidou, A, 2011) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 1.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals." | 1.37 | Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. ( Aktolga, S; Cetinkaya, A; Dorko, K; Gramignoli, R; Marongiu, F; Tahan, G; Tahan, V, 2011) |
| " These results suggest that neither drug has therapeutic efficacy, however dosing and/or administration issues may have played a role." | 1.37 | Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. ( Kelso, ML; Pauly, JR; Scheff, NN; Scheff, SW, 2011) |
| "Melatonin treatment increased total glutathione content and lowered the oxidized/reduced glutathione ratio, indicating a better redox status of the muscle." | 1.37 | Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy. ( Dorchies, OM; Hibaoui, Y; Patthey-Vuadens, O; Reutenauer-Patte, J; Ruegg, UT, 2011) |
| "Melatonin treatment increased leukophagocytosis but was associated with a greater number of dead amoebae." | 1.37 | Melatonin reduces the severity of experimental amoebiasis. ( Caliari, MV; Franca, EL; França, JL; França-Botelho, AC; Gomes, MA; Honório-França, AC; Oliveira, FM, 2011) |
| "Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks." | 1.37 | Interactive effects of melatonin, exercise and diabetes on liver glycogen levels. ( Akil, M; Avunduk, MC; Baltaci, AK; Bicer, M; Kilic, M; Mogulkoc, R, 2011) |
| " Chronic administration of melatonin (2." | 1.37 | Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats. ( Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S, 2011) |
| "Melatonin treatment did not prevent the IR-induced reduction in sperm concentration." | 1.36 | Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats. ( Aral, F; Baba, F; Hekimoglu, A; Kurcer, Z; Sahna, E, 2010) |
| "Melatonin has been reported to be neuroprotective in the 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of PD." | 1.36 | Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. ( Cannon, JR; Greenamyre, JT; Tapias, V, 2010) |
| "Rosiglitazone group had lower adhesion scores [median (min-max ranges)] regarding extent, severity, and degree of the adhesions [0 (0-3), 0 (0-3) and 0 (0-3), respectively], which were significantly different (P < 0." | 1.36 | A randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn model. ( Aksakal, O; Gungor, T; Inan, I; Kalyoncu, S; Mollamahmutoglu, L; Sirvan, L; Sut, N; Yilmaz, B, 2010) |
| "Melatonin treatment was found to be beneficial in acute pancreatitis." | 1.36 | Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. ( Khanduja, KL; Malhotra, S; Pandhi, P; Sidhu, S; Vaiphei, K, 2010) |
| "Melatonin-treated BDL rats received daily melatonin 1 mg/kg/day via intraperitoneal injection." | 1.36 | Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation. ( Chen, CC; Hsieh, CS; Huang, LT; Lee, CT; Sheen, JM; Tain, YL, 2010) |
| "Myocardial infarction was induced by left coronary artery ligation in all rats." | 1.36 | Melatonin augments expression of the procollagen α1 (I) and α1 (III) genes in the infarcted heart scar of pinealectomized rats. ( Drobnik, J; Hrabec, E; Hrabec, Z; Olczak, S; Owczarek, K, 2010) |
| " The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity." | 1.36 | Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury. ( Fee, DB; Gabbita, P; Roberts, K; Scheff, N; Scheff, S; Swartz, KR, 2010) |
| "Melatonin is a potent free radical scavenger and antioxidant and has protective effects against ischemic damage." | 1.36 | Melatonin's protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor. ( Choi, JH; Hwang, IK; Kim, YM; Kwon, YG; Lee, CH; Park, OK; Won, MH; Yoo, KY, 2010) |
| "Melatonin treatment increased apoptotic cells in endometriotic zones." | 1.36 | Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway. ( Bhattacharya, P; Das Mahapatra, P; Paul, S; Swarnakar, S, 2010) |
| "Melatonin treatments increased the SFI values in the injured sciatic nerves." | 1.36 | Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury. ( Bilgin, MD; Yaraneri, H; Zencirci, SG, 2010) |
| "Melatonin is a hormone which has many systemic effects in addition to its strong antioxidant properties." | 1.36 | Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy. ( Akgul, EO; Korkmaz, A; Oter, S; Ozkan, C; Ozler, M; Simsek, K; Topal, T, 2010) |
| " Dosage was in accordance with their pharmacokinetic properties and experience gained with experimental SCI." | 1.35 | Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. ( Franco-Bourland, RE; Grijalva, I; Guízar-Sahagún, G; Ibarra, A; Madrazo, I; Martínez-Cruz, A; Rodríguez-Balderas, CA, 2009) |
| "Treatment with melatonin improved oxygenation and decreased histological lung injury but significantly increased oxidative stress quantified by malondialdehyde levels." | 1.35 | Effects of melatonin in an experimental model of ventilator-induced lung injury. ( Albaiceta, GM; Astudillo, A; Diaz, E; García-Prieto, E; Parra, D; Pedreira, PR; Taboada, F, 2008) |
| "Global cerebral ischemia induces alterations of working memory, as evidenced in the eight-arm radial maze, in the absence of significant changes of pyramidal neuron population in the prefrontal cortex." | 1.35 | Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats. ( Cervantes, M; García-Chávez, D; González-Burgos, I; Letechipía-Vallejo, G; López-Loeza, E; Moralí, G, 2008) |
| "Uveitis is a common ophthalmic disorder that can be induced in hamsters by a single intravitreal injection of bacterial lipopolysaccharide (LPS)." | 1.35 | Therapeutic effect of melatonin in experimental uveitis. ( Aisemberg, J; Aldana Marcos, HJ; Chianelli, MS; Fernandez, DC; Rosenstein, RE; Sáenz, DA; Sande, PH; Silberman, DM, 2008) |
| "Melatonin (15 mg/kg) was administered by intraperitoneal injection at 1, 24, 48, and 72 h." | 1.35 | Long-term effects of melatonin after intracerebral hemorrhage in rats. ( Ayer, R; Hartman, RE; Jadhav, V; Lee, S; Lekic, T; Rojas, HA; Tang, J; Titova, E; Zhang, JH, 2008) |
| "Fragile X syndrome is the most common form of inherited mental retardation." | 1.35 | Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. ( de Diego-Otero, Y; de Fonseca, FR; Decara, J; Del Arco-Herrera, I; el Bekay, R; Romero-Zerbo, Y; Sanchez-Salido, L, 2009) |
| "Melatonin was injected intraperitoneally to a group of rats at the dose of 15 mg/kg 30 min before starting the ischemic procedure (HI-Melatonin)." | 1.35 | Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin. ( Balduini, W; Buonocore, G; Carloni, S; Ciccoli, L; Comporti, M; Leoncini, S; Perrone, S; Signorini, C, 2009) |
| "Most patients with Alzheimer's disease (AD) present decreased levels of melatonin, a day-night rhythm-related hormone." | 1.35 | Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin. ( Fu, ZQ; Ling, ZQ; Tian, Q; Wang, JZ; Wang, L; Wang, Q; Wang, XC, 2009) |
| "Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
| "In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing." | 1.35 | Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009) |
| "The possibility that a portion of the breast cancer burden might be explained by the introduction and increasing use of electricity to light the night was suggested >20 years ago." | 1.35 | Light-at-night, circadian disruption and breast cancer: assessment of existing evidence. ( Stevens, RG, 2009) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the BBB." | 1.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 1.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "Melatonin is known to be a free radical scavenger and an antioxidant agent." | 1.35 | Melatonin prevents cyclosporine-induced hepatotoxicity in rats. ( Atasever, A; Esrefoglu, M; Kurus, M; Sogutlu, G, 2009) |
| "In melatonin and vitamin C-treated groups, eNOS immunoreactivity was diffuse and the intensity of reaction was (+++) in subepicardial region." | 1.35 | Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. ( Akkuş, D; Narin, F; Ozdamar, S; Sönmez, MF, 2009) |
| "Melatonin (MT) has direct and indirect free radical detoxifying activity." | 1.35 | Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia. ( Fu, JH; Pan, L; Wei, B; Xu, W; Xue, XD; Zhou, P, 2009) |
| "Both Melatonin and 1400W were efficient in ameliorating experimental I/R injury of the kidneys." | 1.35 | Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. ( Akgul, EO; Cayci, T; Cetiner, S; Ersoz, N; Guven, A; Korkmaz, A; Oztas, E; Turk, E; Uysal, B, 2009) |
| "Melatonin (MT) plays an important role in the regulation of physiological and neuroendocrine functions, such as control of circadian rhythms and synchronization of seasonal reproductive rhythms in mammals." | 1.35 | [Effects of melatonin on nociception processes in experimentally model of neurophatic pain]. ( Ciesielczyk, K; Machowska, A; Nowak, Ł; Thor, PJ; Zurowski, D, 2008) |
| "The melatonin was administered intraperitoneally at a dose of 5 mg/kg/12 h simultaneously with SAH from day 0 to day 5." | 1.35 | Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. ( Chen, G; Dong, W; Fang, Q; Wang, Z; Zhu, W, 2009) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 1.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "In a model of hemorrhagic shock (MAP 35 +/- 5 mmHg for 90 min) and reperfusion (2 h), we measured nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) autofluorescence, hepatic microcirculation, and hepatocellular injury by intravital microscopy, as well as plasma disappearance rate of indocyanine green (PDRICG) as a sensitive maker of liver function in rat." | 1.35 | Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock. ( Bauer, I; Bentley, A; Kubulus, D; Mathes, AM; Pradarutti, S; Rensing, H; Weiler, J; Wolf, B; Ziegeler, S, 2008) |
| "Treatment with melatonin led to significant decrease in oxidative injury." | 1.35 | Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis. ( Akbas, A; Ozyurt, B; Ozyurt, H; Parlaktas, BS; Tunc, AT, 2008) |
| "Melatonin treatment obviously reduced the deposition of MSSG and elevated hippocampal pyramidal cell number while improving the learning and memory deficits of SAMP8." | 1.35 | Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8. ( Cheng, S; Fan, W; He, H; Ma, C; Pang, J; Qu, H, 2008) |
| "Melatonin-treated animals had better neurologic function than those of the I/R group." | 1.35 | Effects of melatonin on ischemic spinal cord injury caused by aortic cross clamping in rabbits. ( Kardeş, O; Korkmaz, A; Omeroğlu, S; Oyar, EO, 2008) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the blood-brain barrier." | 1.35 | Melatonin decreases mortality following severe subarachnoid hemorrhage. ( Ayer, RE; Chen, W; Sugawara, T; Tong, W; Zhang, JH, 2008) |
| "Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior." | 1.35 | Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008) |
| " The response of the receptors to inhibitors of polyglutamine toxicity is altered by the amino acid exchanges suggesting that careful consideration is needed in the choice of potential therapies of disorders involving toxic polyQ species." | 1.35 | Specific N-terminal mutations in the human androgen receptor induce cytotoxicity. ( Cato, AC; Funderburk, SF; Mink, S; Shatkina, L; Weg-Remers, S; Weis, Q, 2009) |
| "The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 1.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
| "Endometriosis is a gynecological disease of women and plausibly regulated by matrix metalloproteinases (MMPs)." | 1.35 | Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. ( Bhattacharya, P; Mahapatra, PD; Paul, S; Reiter, RJ; Sharma, AV; Swarnakar, S, 2008) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 1.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "Melatonin was found to be superior to octreotide with respect to the prevention of congestion, edema, axonal degeneration and necrosis." | 1.35 | Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. ( Erol, FS; Ilhan, N; Kaplan, M; Ozercan, I; Tiftikci, M; Topsakal, C; Yakar, H, 2008) |
| "Melatonin treatment also resulted with MDA formation (P=0." | 1.34 | The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study. ( Abuşoglu, S; Avunduk, MC; Baysefer, A; Ciçek, O; Kalkan, E; Kalkan, SS; Unlü, A, 2007) |
| "Melatonin (100 mg/kg) was given intraperitoneally immediately after trauma to the rats in the groups 3 and 6." | 1.34 | Does pinealectomy affect the recovery rate after spinal cord injury? ( Altinoz, E; Ates, O; Cayli, S; Gurses, I; Iraz, M; Kocak, A; Yologlu, S; Yucel, N, 2007) |
| "Melatonin treatment prevented qualitative changes in gallbladder neurotransmission, but it did not improve EFS-induced contractility." | 1.34 | Effects of melatonin on gallbladder neuromuscular function in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2007) |
| "Melatonin was injected intraperitoneally (500 microg/kg/day)." | 1.34 | Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats. ( Arjona, A; Cruz, A; Martínez, R; Montilla, P; Muñoz-Castañeda, JR; Muntané, J; Ochoa, L; Padillo, FJ; Ramírez, LM; Recio, M; Túnez, I, 2007) |
| "Melatonin was administered intraperitoneally with two different doses (20mg/kg or 40mg/kg) beginning 1h before HN2 application and continued every 12h for six replications." | 1.34 | Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. ( Korkmaz, A; Kurt, B; Oter, S; Reiter, RJ; Topal, T; Ucar, M; Yaren, H, 2007) |
| "Melatonin has multiple roles including neuroprotection." | 1.34 | Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease. ( McMillan, CR; Niles, LP; Sharma, R, 2007) |
| "Melatonin was administered during the BOP-induction phase (12 wk) and/or following the postinduction phase (12 wk)." | 1.34 | Beneficial properties of melatonin in an experimental model of pancreatic cancer. ( Cruz, A; González, R; Montilla, P; Muñoz-Villanueva, MC; Muntané, J; Padillo, FJ; Perea, MD; Romero, A; Ruiz-Rabelo, JF; Túnez, I; Vázquez, R, 2007) |
| "Hydrocephalus is a disabling disease for children, but current data concerning the effects of melatonin on ventricular enlargement are still limited." | 1.34 | Melatonin ameliorates blood-brain barrier permeability, glutathione, and nitric oxide levels in the choroid plexus of the infantile rats with kaolin-induced hydrocephalus. ( Erdogan, S; Ergin, K; Serter, M; Turgut, M, 2007) |
| "Melatonin (10 mg/kg) was administered i." | 1.33 | Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury. ( Emekli, N; Sener, G; Tunali, T; Yarat, A, 2005) |
| " We observed that chronic administration of melatonin significantly reduced the lipid peroxidation and restored the decreased glutathione levels induced by chronic hyperhomocysteinemia." | 1.33 | Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats. ( Baydas, G; Koz, ST; Ozer, M; Tuzcu, M; Yasar, A, 2005) |
| "The melatonin effect was mediated by modulating the release of pro-/anti-inflammatory cytokine levels, protection from oxidative damage and counteracting apoptotic cell death." | 1.33 | Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects. ( Calvo, JR; Carrillo-Vico, A; Fernández-Santos, JM; Guerrero, JM; Lardone, PJ; Martín-Lacave, I; Naji, L, 2005) |
| "Melatonin-treated groups showed more ultrastructural improvement on electron microscope studies when compared with methylprednisone group." | 1.33 | Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats. ( Bilge, T; Celik, SE; Cokar, N; Gül, S; Kalayci, M; Taşyürekli, M, 2005) |
| "Melatonin has direct and indirect free radical-detoxifying activity." | 1.33 | Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats. ( Erdogan, H; Fadillioglu, E; Iraz, M; Kotuk, M; Kuku, I; Yagmurca, M; Yildirim, Z, 2006) |
| "Melatonin is a potent endogenous antioxidant and free radical scavenger." | 1.33 | Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. ( Chang, Y; Feng, Z; Qin, C; Zhang, JT, 2006) |
| "Melatonin or vehicle was administered 1 h before flap elevation and was continued for 6 days after ischemia." | 1.33 | The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats. ( Aydogan, H; Bay-Karabulut, A; Celik, M; Gurlek, A; Parlakpinar, H, 2006) |
| "Cadmium concentration was measured in the liver, kidneys, testes and brain by AAS." | 1.33 | Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice. ( Eybl, V; Kotyzova, D; Koutensky, J, 2006) |
| "Melatonin treatment improved the penumbral CBF in the wild-type mice." | 1.33 | Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. ( Cheung, RT; Huang, L; Li, G; Liu, S; Zou, LY, 2006) |
| "Neuronal injury is frequent in bacterial meningitis, resulting in a high rate of death and neurological sequelae." | 1.33 | Antiinflammatory but no neuroprotective effects of melatonin under clinical treatment conditions in rabbit models of bacterial meningitis. ( Baake, D; Gerber, J; Hanssen, M; Huether, G; Nau, R; Spreer, A, 2006) |
| "Melatonin was administered as an antioxidant." | 1.32 | Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. ( Nava, M; Quiroz, Y; Rodriguez-Iturbe, B; Vaziri, N, 2003) |
| "Treatment with melatonin at 1." | 1.32 | Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Fung, PC; Pei, Z, 2003) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 1.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| "Pituitary tumors were induced by subcutaneous implantation of a single silastic capsule containing 10 mg of diethylstilbestrol in 4-wk-old male Fischer 344 rats." | 1.32 | Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors. ( Gruszka, A; Karasek, M; Kunert-Radek, J; Lawnicka, H; Pawlikowski, M, 2003) |
| "Melatonin was the most powerful agent, particularly at the fourth hour." | 1.32 | Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. ( Akdemir, I; Gursu, F; Kaplan, M; Kilic, N; Ozveren, F; Tiftikci, M; Topsakal, C, 2003) |
| "Melatonin was administered either 10 min before aortic occlusion or 10 min after the clamp was removed." | 1.32 | Protective effect of melatonin on experimental spinal cord ischemia. ( Aydemir, S; Colak, A; Erten, SF; Kocak, A; Ozdemir, I; Reeder, BS, 2003) |
| "The influence of dosing time on the antitumor effect and the rhythm disturbance effect of melatonin (MLT) was investigated in ICR male mice under a light/dark (12:12) cycle." | 1.32 | Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect. ( Akagi, T; Hamase, K; Higuchi, S; Ikesue, S; Ohdo, S; Ushinohama, K; Yukawa, E; Zaitsu, K, 2004) |
| "Treatment with melatonin resulted in an obvious reduction of GFAP-immunoreactive astrocytes in hippocampus." | 1.32 | Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. ( Akdemir, I; Baydas, G; Nedzvetskii, VS; Reiter, RJ; Tuzcu, M; Yasar, A, 2003) |
| "Melatonin is an endogenous antioxidant and free radical scavenger." | 1.32 | Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease. ( Chang, Y; Cheng, Y; Feng, Z; Qin, C; Qu, ZW; Zhang, BL; Zhang, JT, 2004) |
| "Melatonin is an endogenously generated potent antioxidant." | 1.32 | Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats. ( Cheng, Y; Feng, Z; Zhang, JT, 2004) |
| " However, one dosage pretreatment, but not post-treatment, of baicalein (5 or 10 mg/kg, i." | 1.32 | Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. ( Chen, CF; Chi, CW; Liao, JF; Wang, HH; Wang, SY, 2004) |
| "Pretreatment with melatonin dramatically improved survival rate of rats when compared with the I/R-only group." | 1.31 | Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. ( Chen, HR; Hsiao, G; Lee, YM; Sheu, JR; Wang, JJ; Yen, MH, 2002) |
| "Melatonin was administered i." | 1.31 | Melatonin improves oxidative organ damage in a rat model of thermal injury. ( Keyer-Uysal, M; Satiroğlu, H; Sehirli, AO; Sener, G; Yeğen, BC, 2002) |
| " We investigated whether long-term administration of physiological levels of melatonin, a direct free radical scavenger and indirect antioxidant, influences mitochondrial respiratory activity in liver of senescence-accelerated mice (SAM)." | 1.31 | Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin. ( Miyahara, Y; Okatani, Y; Reiter, RJ; Wakatsuki, A, 2002) |
| " Chronic administration of melatonin (0." | 1.31 | Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. ( Kulkarni, SK; Raghavendra, V, 2001) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 1.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| "Treatment with melatonin decreased the renal lipid peroxidation, and both the reduced glutathione as well as the scavenger enzyme activity recovered." | 1.31 | Melatonin protects against renal oxidative stress after obstructive jaundice in rats. ( Cruz, A; Granados, J; Montilla, P; Muñoz, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2001) |
| "Periventricular leukomalacia is one of the main causes of cerebral palsy." | 1.31 | Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. ( Bac, P; Evrard, P; Gressens, P; Husson, I; Mesplès, B; Vamecq, J, 2002) |
| "Melatonin is a potent scavenger of free radicals and an indirect antioxidant." | 1.31 | Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2002) |
| " We found that the antioxidant melatonin (500 microg/kg bw) prevents cell death as well as the damage induced by chronic administration of MPTP measured as number of nigral cells, tyrosine hydroxylase levels, and several ultra-structural features." | 1.31 | Protective effect of melatonin in a chronic experimental model of Parkinson's disease. ( Antolín, I; del Brío, Mde L; Herrera, F; Martín, V; Mayo, JC; Rodríguez, C; Sainz, RM, 2002) |
| " The apparent elimination half-life of melatonin following an intravenous dose of 3 mg/kg (5 mg/kg in rats) was 19." | 1.30 | Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. ( Knipe, JO; McLaughlin, LG; Schabdach, D; Yeleswaram, K, 1997) |
| "Scoliosis was not observed in either the rats or the hamsters." | 1.30 | The production of scoliosis after pinealectomy in young chickens, rats, and hamsters. ( Bagnall, K; Mahood, J; Moreau, M; O'Kelly, C; Raso, J; Wang, X; Zhao, J, 1999) |
| "Scoliosis was assessed on weekly radiographs, and the Cobb angle was determined for all chickens in which scoliosis developed." | 1.30 | The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken. ( Bagnall, K; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Zhao, J, 1999) |
| " These results are consistent with previous work highlighting the importance of aberrant amine production in neurological disease and demonstrate that treatments that reduce endogenous melatonin bioavailability can ameliorate experimental PD." | 1.30 | A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease. ( Armstrong, SM; Willis, GL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (0.90) | 18.7374 |
| 1990's | 21 (2.37) | 18.2507 |
| 2000's | 224 (25.31) | 29.6817 |
| 2010's | 465 (52.54) | 24.3611 |
| 2020's | 167 (18.87) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 5 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Stefek, M | 1 |
| Tsantili-Kakoulidou, A | 1 |
| Milackova, I | 1 |
| Juskova, M | 1 |
| Snirc, V | 1 |
| Triantos, N | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 2 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Çokluk, E | 1 |
| Doğanay, S | 1 |
| Ramazan Şekeroğlu, M | 1 |
| Betül Tuncer, F | 1 |
| Çakıroğlu, H | 1 |
| Boz, M | 1 |
| Liu, X | 8 |
| Zhang, Y | 15 |
| Ren, Y | 2 |
| Li, J | 6 |
| Li, X | 10 |
| He, J | 1 |
| Li, Y | 12 |
| Zhou, Y | 3 |
| Cai, S | 1 |
| Ren, Q | 1 |
| Gao, D | 1 |
| Mou, L | 1 |
| Zhang, S | 8 |
| Zhang, M | 7 |
| Li, N | 3 |
| Sik, A | 1 |
| Jin, M | 2 |
| Liu, K | 3 |
| Ghosh, H | 2 |
| Rai, S | 2 |
| Manzar, MD | 1 |
| Pandi-Perumal, SR | 3 |
| Brown, GM | 1 |
| Reiter, RJ | 25 |
| Cardinali, DP | 3 |
| Favrais, G | 1 |
| Saliba, E | 1 |
| Savary, L | 1 |
| Bodard, S | 1 |
| Gulhan, Z | 1 |
| Gressens, P | 6 |
| Chalon, S | 1 |
| Bai, Y | 1 |
| Xu, C | 1 |
| Lin, J | 4 |
| Jin, J | 1 |
| Xu, A | 1 |
| Lou, JN | 1 |
| Qian, C | 1 |
| Yu, W | 1 |
| Wu, Y | 5 |
| Qi, Y | 1 |
| Tao, H | 1 |
| Al-Otaibi, AM | 1 |
| Al-Gebaly, AS | 1 |
| Almeer, R | 1 |
| Albasher, G | 1 |
| Al-Qahtani, WS | 1 |
| Abdel Moneim, AE | 2 |
| Obayemi, MJ | 1 |
| Akintayo, CO | 1 |
| Oniyide, AA | 1 |
| Aturamu, A | 1 |
| Badejogbin, OC | 1 |
| Atuma, CL | 1 |
| Saidi, AO | 1 |
| Mahmud, H | 1 |
| Olaniyi, KS | 1 |
| Endepols, H | 1 |
| Zlatopolskiy, BD | 1 |
| Zischler, J | 1 |
| Alavinejad, N | 1 |
| Apetz, N | 1 |
| Vus, S | 1 |
| Drzezga, A | 1 |
| Neumaier, B | 1 |
| Nikmard, F | 1 |
| Hosseini, E | 1 |
| Bakhtiyari, M | 1 |
| Ashrafi, M | 1 |
| Amidi, F | 1 |
| Aflatoonian, R | 1 |
| Chen, X | 3 |
| Shen, X | 4 |
| Lai, J | 1 |
| Yao, Z | 1 |
| Peng, X | 2 |
| Wu, L | 1 |
| Ou, Y | 1 |
| Wu, H | 3 |
| Zhu, H | 4 |
| Deng, Y | 5 |
| Song, Z | 1 |
| Bao, L | 1 |
| Deng, W | 1 |
| Liu, J | 8 |
| Ren, E | 1 |
| Lv, Q | 1 |
| Liu, M | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Potential Role of Melatonin in Subjects With Relapsing Multiple Sclerosis (MS)[NCT03498131] | Early Phase 1 | 30 participants (Actual) | Interventional | 2018-05-09 | Completed | ||
| Association of Anesthesia Technique With Morbidity and Mortality in Patients With COVID-19 and Surgery for Hip Fracture: a Retrospective Population Cohort Study[NCT05133648] | 1,000 participants (Anticipated) | Observational | 2023-01-05 | Active, not recruiting | |||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| The Intervention Effect Of Melatonin On The Risk Of Cardiovascular Events And Malignant Tumors In The Elderly: A Prospective, Randomized Parallel Controlled Study Based On Large Cohorts[NCT04631341] | 10,000 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | |||
| The Protective Effect of Melatonin on Smoke-induced Vascular Injury in Human[NCT02591238] | Phase 4 | 68 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435] | 160 participants (Actual) | Interventional | 2016-08-22 | Completed | |||
| The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment[NCT05298657] | 200 participants (Anticipated) | Observational [Patient Registry] | 2022-09-01 | Not yet recruiting | |||
| Phase II Double-blind Randomized Placebo-controlled 1-way Crossover Trial to Investigate Safety and Efficacy of the Ascorbic Acid and Tocopherol for the Treatment of the Fragile X Syndrome[NCT01329770] | Phase 2 | 30 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432] | Phase 2 | 40 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Melatonin and Essential Arterial Hypertension[NCT05257291] | Phase 2 | 23 participants (Actual) | Interventional | 2018-02-02 | Active, not recruiting | ||
| A Single Center, Open Label Prospective Observational Pilot Study to Evaluate the Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)[NCT05922995] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Scoliosis Patients Aged 10-13 Years: Monitoring of Scoliosis by the Surface Topography[NCT02531945] | 125 participants (Actual) | Interventional | 2015-09-30 | Completed | |||
| Pilot Study of Memantine for Enhanced Stroke Recovery[NCT02144584] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2014-01-31 | Active, not recruiting | ||
| Prognostic Value of Indocyanine Clearance Rate for Sepsis Patients in ICU[NCT01447836] | 100 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| Influence of Radiation Patterns Following Circadian Rhythm Upon Response of Radiotherapy of Uterine Cervical Cancer : Melatonin as a Radiosensitivity and Biological Marker[NCT05511740] | 71 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02591238)
Timeframe: Three months
| Intervention | g/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 2.76 |
| III Non-smoker + Melatonin | 2.38 |
| II Smoker + Placebo | 2.89 |
| I Smoker + Melatonin | 2.49 |
(NCT02591238)
Timeframe: Three months.
| Intervention | umol/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 389 |
| III Non-smoker + Melatonin | 382 |
| II Smoker + Placebo | 499 |
| I Smoker + Melatonin | 425 |
(NCT02591238)
Timeframe: Three months.
| Intervention | mmol/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 4.4 |
| III Non-smoker + Melatonin | 4.24 |
| II Smoker + Placebo | 5.02 |
| I Smoker + Melatonin | 4.79 |
(NCT02591238)
Timeframe: Three months.
| Intervention | mmol/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 1.85 |
| III Non-smoker + Melatonin | 1.95 |
| II Smoker + Placebo | 2.2 |
| I Smoker + Melatonin | 2.19 |
(NCT02591238)
Timeframe: Three months.
| Intervention | mmol/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 4.51 |
| III Non-smoker + Melatonin | 4.5 |
| II Smoker + Placebo | 4.74 |
| I Smoker + Melatonin | 4.45 |
(NCT02591238)
Timeframe: Three months.
| Intervention | mmol/L (Mean) |
|---|---|
| IV Non-smoker + Placebo | 1.21 |
| III Non-smoker + Melatonin | 1.23 |
| II Smoker + Placebo | 1.42 |
| I Smoker + Melatonin | 1.41 |
The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| RIPC | 5 |
| Control | 0 |
The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation
| Intervention | IU/L (Mean) |
|---|---|
| RIPC | 145 |
| Control | 152 |
The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month
| Intervention | percentage of liver volume (Mean) |
|---|---|
| RIPC | 83.3 |
| Control | 94.9 |
The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation
| Intervention | IU/L (Mean) |
|---|---|
| RIPC | 148 |
| Control | 152 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
67 reviews available for melatonin and Disease Models, Animal
| Article | Year |
|---|---|
Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Disease Models, Animal; Maze Learning; | 2022 |
Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.
Topics: Animals; Disease Models, Animal; Humans; Infertility, Male; Male; Melatonin; Semen; Testis | 2023 |
Molecular mechanisms of melatonin-induced alleviation of synaptic dysfunction and neuroinflammation in Parkinson's disease: a review.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammasomes; Melatonin; Mice; Mice, | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Pharmacological Effects of Melatonin as Neuroprotectant in Rodent Model: A Review on the Current Biological Evidence.
Topics: Animals; Apoptosis; Disease Models, Animal; Melatonin; Nervous System Diseases; Neuroprotective Agen | 2020 |
Circadian insights into the biology of depression: Symptoms, treatments and animal models.
Topics: Animals; Biological Clocks; Circadian Rhythm; Depression; Depressive Disorder; Disease Models, Anima | 2019 |
Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cofilin 1; Cytokines; Disease Models, Animal; Hum | 2019 |
Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies.
Topics: Animals; Disease Models, Animal; Melatonin; Mice; Myocardial Reperfusion Injury; Rats | 2020 |
Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Circadian Rhythm; Cognitive Dysfunction; D | 2020 |
Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cerebral Hemorrhage; Disease Models, Animal; Melato | 2021 |
Potential therapeutic agents for ischemic white matter damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Edaravone; H | 2021 |
Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Melatonin; Neonatal Sepsis; Treatment Outcome | 2017 |
Molecular mechanisms of nickel induced neurotoxicity and chemoprevention.
Topics: Animals; Carnitine; Cell Line; Chemoprevention; Disease Models, Animal; DNA Damage; DNA, Mitochondri | 2017 |
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases.
Topics: Alzheimer Disease; Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug | 2018 |
Anti-inflammatory effects of Melatonin: A mechanistic review.
Topics: Animals; Anti-Inflammatory Agents; Cardiovascular System; Chronic Disease; Clinical Trials as Topic; | 2019 |
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
Topics: Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Disease Models, Animal; Disea | 2018 |
The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Diseases; Disease Models, Animal; Humans; M | 2019 |
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD).
Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Disease Models, Animal; Endpoint Determination; | 2020 |
Current understanding of pineal gland structure and function in headache.
Topics: Adult; Animals; Calcitonin Gene-Related Peptide; Case-Control Studies; Child; Circadian Rhythm; Clin | 2019 |
Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Humans; Melatonin; Oxidative Stress; Parkinso | 2020 |
Agrypnia excitata.
Topics: Alcohol Withdrawal Delirium; Animals; Atrophy; Autoantibodies; Autoantigens; Disease Models, Animal; | 2013 |
Melatonin and the skeleton.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Circadian Rhythm; Diseas | 2013 |
Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Clinical Trials as Topic; Disease Models, Animal; Humans; Inflammation | 2013 |
Melatonin: its possible role in the management of viral infections--a brief review.
Topics: Animals; Antioxidants; Cohort Studies; Disease Models, Animal; Encephalitis, Viral; Female; Humans; | 2013 |
Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
Topics: Animals; Benzodiazepines; Brain; Brain Mapping; Circadian Rhythm; Cognitive Behavioral Therapy; Comb | 2013 |
[Circadian rhythm and inflammatory bowel disease].
Topics: Animals; Chronotherapy; Circadian Rhythm; Disease Models, Animal; Humans; Inflammatory Bowel Disease | 2013 |
Circadian rhythms, insulin action, and glucose homeostasis.
Topics: Animals; Blood Glucose; Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Diet, Carbohydr | 2014 |
Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease.
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Melatonin; Mic | 2014 |
Melatonin and metabolic regulation: a review.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hyperglycemia; M | 2014 |
A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Animals; Chickens; Disease Models, Animal; Female; Haplorhini; Humans; Male; Melatonin; | 2014 |
Role of melatonin in traumatic brain injury and spinal cord injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Humans; Melatonin; Neuroprotective Agents; Oxidativ | 2014 |
Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries.
Topics: Angioplasty, Balloon, Coronary; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Infla | 2015 |
Melatonin for Spinal Cord Injury in Animal Models: A Systematic Review and Network Meta-Analysis.
Topics: Animals; Antioxidants; Disease Models, Animal; Melatonin; Rats; Spinal Cord Injuries | 2016 |
Melatonin as a pro-osteogenic agent in oral implantology: a systematic review of histomorphometric outcomes in animals and quality evaluation using ARRIVE guidelines.
Topics: Animals; Dental Implantation, Endosseous; Disease Models, Animal; Dogs; Melatonin; Osseointegration; | 2017 |
The Potential Role of Melatonin on Memory Function: Lessons from Rodent Studies.
Topics: Animals; Disease Models, Animal; Humans; Melatonin; Memory; Memory Disorders; Rodentia | 2016 |
The circadian rhythm and its interaction with human epilepsy: a review of literature.
Topics: Adult; Animals; Biological Clocks; Body Temperature Regulation; Brain; Child; Circadian Rhythm; CLOC | 2009 |
[Melatonina: old molecule, new medicament].
Topics: Administration, Oral; Age Factors; Aged; Alzheimer Disease; Animals; Antioxidants; Central Nervous S | 2008 |
Melatonin--a pleiotropic molecule involved in pathophysiological processes following organ transplantation.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Immunologic; Graft Reject | 2009 |
Melatonin in septic shock: some recent concepts.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni | 2010 |
Hepatoprotective actions of melatonin: possible mediation by melatonin receptors.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Humans; Liver; Melatonin; Oxidative Stress | 2010 |
The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS).
Topics: Adolescent; Animals; Disease Models, Animal; Humans; Melatonin; Scoliosis | 2011 |
Melatonin in experimental seizures and epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Child; Disease Models, Animal; Epilepsy; Humans; Melatonin; | 2011 |
[Effects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model].
Topics: Aging; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycog | 2011 |
Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.
Topics: Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Humans; Irritable Bowel Syndrome; Male; M | 2011 |
Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression.
Topics: Adolescent; Adult; Animals; Child; Chronobiology Disorders; Comorbidity; Disease Models, Animal; Hum | 2012 |
The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Ho | 2012 |
Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation?
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Humans; Melatonin; Neuroprotective Agents; Pa | 2012 |
Pathogenesis of idiopathic scoliosis: a review.
Topics: Adolescent; Animals; Biomechanical Phenomena; Bone Development; Calmodulin; Child; Disease Models, A | 2012 |
Ocular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential.
Topics: Animals; Disease Models, Animal; Drug Design; Eye Diseases; Humans; Melatonin | 2012 |
Agomelatine in depressive disorders: its novel mechanisms of action.
Topics: Acetamides; Animals; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Disease Models, | 2012 |
[Therapeutic possibilities of a pineal hormone melatonin in the cranial-brain injury].
Topics: Animals; Craniocerebral Trauma; Cytoprotection; Disease Models, Animal; Humans; Melatonin; Neuroprot | 2012 |
Melatonin oxidative stress and neurodegenerative diseases.
Topics: Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Humans; Melatonin; Neurodege | 2002 |
Therapeutic perspectives for melatonin agonists and antagonists.
Topics: Animals; Anxiety; Body Weight; Brain; Cerebrovascular Circulation; Chronobiology Disorders; Circadia | 2003 |
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Humans; Melatonin; Neuroprotec | 2003 |
Does melatonin play a disease-promoting role in rheumatoid arthritis?
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Melatonin; Periodicity | 2005 |
Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke.
Topics: Animals; Disease Models, Animal; Melatonin; Neuroprotective Agents; Stroke | 2005 |
[Development of a new antidepressant : agomelatine].
Topics: Acetamides; Animals; Circadian Rhythm; Depressive Disorder; Disease Models, Animal; Humans; Hypnotic | 2005 |
Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Circadian Rhythm; Dietary Supplements; Dise | 2005 |
The role of ML-23 and other melatonin analogues in the treatment and management of Parkinson's disease.
Topics: 5-Methoxytryptamine; Animals; Antiparkinson Agents; Disease Models, Animal; Humans; Levodopa; Melato | 2005 |
Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system.
Topics: Acetamides; Animals; Antidepressive Agents; Biological Clocks; Brain; Depressive Disorder, Major; Di | 2006 |
Of mice and women: light as a circadian stimulus in breast cancer research.
Topics: Animals; Breast Neoplasms; Circadian Rhythm; Disease Models, Animal; Female; Humans; Light; Light Si | 2006 |
Melatonin as a potential antihypertensive treatment.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Disease Models, Animal; Female; | 2007 |
Oxidative damage in the central nervous system: protection by melatonin.
Topics: Animals; Antioxidants; Central Nervous System Diseases; Disease Models, Animal; Free Radical Scaveng | 1998 |
[Possible role of the pineal gland in the pathogenesis of idiopathic scoliosis. Experimental and clinical studies].
Topics: Animals; Blood Platelets; Calmodulin; Chickens; Disease Models, Animal; Disease Progression; Growth | 2001 |
Chronobiological regulation of alcohol intake.
Topics: Alcohol Drinking; Animals; Circadian Rhythm; Disease Models, Animal; Humans; Lighting; Melatonin; Ra | 2001 |
Melatonin: from basic research to cancer treatment clinics.
Topics: Animals; Antioxidants; Clinical Trials as Topic; Disease Models, Animal; Free Radical Scavengers; Hu | 2002 |
[Epiphysis cerebri and depression (review)].
Topics: Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Disease Models, Animal; Human | 1991 |
5 trials available for melatonin and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The Effect of Melatonin on Periodontitis.
Topics: Animals; Antioxidants; Biomarkers; Disease Models, Animal; Humans; Inflammation; Male; Melatonin; Mi | 2021 |
Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain.
Topics: Analysis of Variance; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Central Nervous Syst | 2015 |
Efficacy of melatonin and hyaluronate/carboxymethylcellulose membrane in preventing adhesion reformation following adhesiolysis in a rat uterine model.
Topics: Administration, Topical; Animals; Carboxymethylcellulose Sodium; Combined Modality Therapy; Disease | 2011 |
Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Infarction; Caspase 3; Cell Count; Cel | 2012 |
814 other studies available for melatonin and Disease Models, Animal
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.
Topics: Acetates; Aldehyde Reductase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models | 2011 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis.
Topics: Animals; Disease Models, Animal; Inflammation Mediators; Matrix Metalloproteinase 2; Melatonin; Rats | 2021 |
Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; | 2021 |
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2021 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression R | 2022 |
Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain; Chorioamnionitis; Cytokines; Disease Mod | 2021 |
Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats.
Topics: Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Liberation; Hydrogel | 2021 |
Melatonin pre-treated bone marrow derived-mesenchymal stem cells prompt wound healing in rat models.
Topics: Animals; Antioxidants; Disease Models, Animal; Interleukin-1beta; Melatonin; Mesenchymal Stem Cell T | 2022 |
Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Ghrelin | 2021 |
Imaging of cerebral tryptophan metabolism using 7-[
Topics: Animals; Disease Models, Animal; Fluorine Radioisotopes; Hippocampus; Kynurenine; Male; Melatonin; O | 2022 |
The boosting effects of melatonin on the expression of related genes to oocyte maturation and antioxidant pathways: a polycystic ovary syndrome- mouse model.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bone Morphogenetic Protein 15; Dehydro | 2022 |
Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway.
Topics: Animals; Bcl-2-Like Protein 11; Behavior, Animal; Brain; Brain Ischemia; Computational Biology; Dise | 2022 |
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients.
Topics: Amino Acids; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; F | 2022 |
Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; CRISPR-Cas Systems; Disease Models, An | 2022 |
TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Creatinine; Disease Mo | 2022 |
Topical Melatonin Exerts Immunomodulatory Effect and Improves Dermatitis Severity in a Mouse Model of Atopic Dermatitis.
Topics: Administration, Topical; Animals; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Model | 2022 |
Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Hyalu | 2022 |
Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats.
Topics: Acetylcholinesterase; Animals; Brain Ischemia; Cognition; Disease Models, Animal; Endoplasmic Reticu | 2022 |
Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2-mediated chromatin remodelling.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Cell Differentiation; Chromatin Assembly and Di | 2022 |
Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats.
Topics: Animals; Antioxidants; Bile Ducts; Disease Models, Animal; Flavanones; Hepatic Encephalopathy; Male; | 2022 |
Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia.
Topics: Animals; Disease Models, Animal; Dopamine; Melatonin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; My | 2022 |
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Lactic Acid; Melatonin | 2022 |
A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Anima | 2022 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Humans; Immunity; Melatonin; Mice; Mice, Inbre | 2022 |
Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3β-Wnt/β-catenin signaling pathway.
Topics: Acetylcholinesterase; Aluminum Chloride; Alzheimer Disease; Animals; beta Catenin; Dietary Supplemen | 2022 |
Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy.
Topics: Animals; Autophagy; Beclin-1; Disease Models, Animal; Hepatic Stellate Cells; Liver Cirrhosis; Melat | 2022 |
Melatonin Alleviates Venous Dysfunction in a Mouse Model of Iliac Vein Occlusion.
Topics: Animals; Disease Models, Animal; Humans; Iliac Vein; Melatonin; Mice; RNA, Messenger; Tumor Necrosis | 2022 |
Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models.
Topics: Animals; Colitis; Dextran Sulfate; Dextrans; Disease Models, Animal; Enhancer of Zeste Homolog 2 Pro | 2022 |
The metastatic spread of breast cancer accelerates during sleep.
Topics: Animals; Breast Neoplasms; Cell Count; Cell Proliferation; Disease Models, Animal; Female; Glucocort | 2022 |
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
Topics: Animals; Cholangitis, Sclerosing; Cholestasis; Disease Models, Animal; Drinking Water; Glutathione; | 2022 |
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1.
Topics: Aging; Aminobutyrates; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; gamma-Ami | 2022 |
Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Chelating A | 2022 |
Melatonin arrests excessive inflammatory response and apoptosis in lipopolysaccharide-damaged rat liver: A deeper insight into its mechanism of action.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Lipopolysaccharides; Liver; Melatonin; Rat | 2022 |
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage.
Topics: Animals; Comorbidity; Disease Models, Animal; Hemorrhage; Humans; Melatonin; Pain; Sleep | 2022 |
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Ferroptosis; Lipopolysaccharides; Malondialdeh | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulm | 2022 |
Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway.
Topics: Animals; Biological Factors; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Hu | 2022 |
Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Stroke; Melatonin; | 2022 |
RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice.
Topics: Animals; Bone Marrow; Colitis; Colon; Cytokines; Dendritic Cells; Dextran Sulfate; Disease Models, A | 2022 |
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroacupuncture; Melatonin; Mice; Mice, Trans | 2023 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Hydrocortisone; Melat | 2023 |
Melatonin protects retinal integrity through mediated immune homeostasis in the sodium iodate-induced mouse model of age-related macular degeneration.
Topics: Aged; Animals; Disease Models, Animal; Homeostasis; Humans; Macular Degeneration; Melatonin; Mice; R | 2023 |
Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Interleukin-6; Melatonin; Neuralgia; Ne | 2023 |
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Disease Models, Animal; Ferroptosis; Head a | 2023 |
Effects of melatonin on a d-galactose-induced male reproductive aging mouse model.
Topics: Aging; Animals; Disease Models, Animal; Galactose; Male; Melatonin; Mice; Rodent Diseases; Semen; Te | 2023 |
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
Therapeutic Benefit of Melatonin in Choroidal Neovascularization During Aging Through the Regulation of Senescent Macrophage/Microglia Polarization.
Topics: Animals; Choroidal Neovascularization; Disease Models, Animal; Interleukin-10; Macrophages; Melatoni | 2023 |
Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus.
Topics: Animals; Antioxidants; Blotting, Western; Brain-Derived Neurotrophic Factor; Cuprizone; Cyclic AMP R | 2019 |
Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway.
Topics: Animals; Apoptosis; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Immunohistochemistry; Inf | 2019 |
Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspase 3; Disease Models, Animal; Erectile Dysfunctio | 2019 |
Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach.
Topics: Animals; Celecoxib; Computational Biology; Disease Models, Animal; Ethanol; Injections, Intraperiton | 2019 |
Combined Therapy With Hyperbaric Oxygen and Melatonin Effectively Reduce Brain Infarct Volume and Preserve Neurological Function After Acute Ischemic Infarct in Rat.
Topics: Animals; Apoptosis; Brain; Brain Infarction; Brain Ischemia; Disease Models, Animal; Hyperbaric Oxyg | 2019 |
[Melatonin effects in young and aged mice with toxic cuprizone-induced model of demyelination.]
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Melatonin; Mice; M | 2019 |
Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid-predominant mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cholineste | 2019 |
Efficacy of a low-dose melatonin pretreatment in protecting against the neurobehavioral consequences of chronic hypoperfusion in middle-aged female rats.
Topics: Age Factors; Animals; Behavior, Animal; Cerebrovascular Circulation; Cognitive Dysfunction; Disease | 2020 |
Reversal of Schizophrenia-like Symptoms and Cholinergic Alterations by Melatonin.
Topics: Animals; Cholinergic Agents; Disease Models, Animal; Humans; Male; Melatonin; Mice; Schizophrenia | 2019 |
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippoc | 2020 |
Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Isolated Hea | 2020 |
Haloperidol-induced hypokinesia in rats is differentially affected by the light/dark phase, age, and melatonin.
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Depressants; Disease Models, Animal; | 2020 |
Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats.
Topics: Alzheimer Disease; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Mo | 2020 |
Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Female; Humans; Huntington Disease; Male; Melaton | 2020 |
Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension.
Topics: Adult; Animals; Anti-Inflammatory Agents; Biomarkers; Calcium; Case-Control Studies; Caspase 1; Casp | 2020 |
Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Galactosamine; | 2020 |
Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants.
Topics: Animals; C-Reactive Protein; Disease Models, Animal; Humans; Intensive Care Units; Light; Male; Malo | 2020 |
Melatonin alleviates oxidative stress in sleep deprived mice: Involvement of small intestinal mucosa injury.
Topics: Animals; Disease Models, Animal; Enteritis; Intestinal Mucosa; Intestine, Small; Male; Melatonin; Mi | 2020 |
Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma.
Topics: Airway Remodeling; Animals; Asthma; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; | 2020 |
Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Collagen Type II; Disease Models, Animal; Humans; Inte | 2019 |
Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Inflammation; Male; Melatonin; Mice, Inbred C57BL; Micr | 2020 |
Ischemic postconditioning reduced myocardial ischemia-reperfusion injury: The roles of melatonin and uncoupling protein 3.
Topics: Animals; Disease Models, Animal; Ischemic Postconditioning; Male; Melatonin; Myocardial Reperfusion | 2020 |
Melatonin ameliorates some biochemical alterations following ketoconazole administration in rats.
Topics: Animals; Antifungal Agents; Central Nervous System Depressants; Disease Models, Animal; Follicle Sti | 2020 |
Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway.
Topics: Animals; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Gene Knockdown Techniques; HS | 2020 |
Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility.
Topics: Animals; Antigens, Neoplasm; Cell Line; Cellular Senescence; Cumulus Cells; Disease Models, Animal; | 2020 |
A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cisplatin; | 2020 |
New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Electroretinography; Female; Gene Expression R | 2020 |
Role of melatonin in prevention of age-related hearing loss.
Topics: Administration, Oral; Animals; Antioxidants; Cadherins; Disease Models, Animal; Hair Cells, Auditory | 2020 |
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.
Topics: Animals; Bacteroidetes; Cell Differentiation; Colitis, Ulcerative; Dextran Sulfate; Disease Models, | 2020 |
Melatonin inhibits macrophage infiltration and promotes plaque stabilization by upregulating anti-inflammatory HGF/c-Met system in the atherosclerotic rabbit: USPIO-enhanced MRI assessment.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Contrast Medi | 2020 |
A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Drug Delivery Systems; Ferrosoferric Oxide; Fibrosis; | 2020 |
Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis.
Topics: Animals; Butyric Acid; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Disease Models, An | 2020 |
Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation.
Topics: Actins; Animals; Biomarkers; Cell Survival; Cell Transdifferentiation; Disease Models, Animal; Disea | 2020 |
Loading-induced antitumor capability of murine and human urine.
Topics: Adolescent; Adult; Animals; Cell Line, Tumor; Disease Models, Animal; Dopamine; Exercise; Female; Hu | 2020 |
Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Disease Models, Animal; Gene Expression Regula | 2020 |
Melatonin Attenuates Calcium Deposition from Vascular Smooth Muscle Cells by Activating Mitochondrial Fusion and Mitophagy via an AMPK/OPA1 Signaling Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Calcium; Disease Models, Animal; GTP Phosphohy | 2020 |
The Role of Melatonin in Electroacupuncture Alleviating Lung Injury Induced by Limb Ischemia-Reperfusion in Rabbits.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Lung Injury; Melatonin; Rabbits; Reperfusion; R | 2020 |
Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury.
Topics: Animals; Astrocytes; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Glucose; Heart; Male; Me | 2020 |
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
Topics: Animals; Animals, Newborn; Biological Availability; Brain; Chemistry, Pharmaceutical; Disease Models | 2020 |
Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release.
Topics: Animals; Asthma; Calcitonin Gene-Related Peptide; Cytokines; Dibutyl Phthalate; Disease Models, Anim | 2020 |
Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment.
Topics: Animals; Antioxidants; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Male; Melatonin; Mit | 2020 |
Melatonin modulates mitophagy, innate immunity and circadian clocks in a model of viral-induced fulminant hepatic failure.
Topics: Animals; Biomarkers; Capsid Proteins; Circadian Clocks; Disease Models, Animal; Hemorrhagic Disease | 2020 |
Melatonin attenuates hypertension and oxidative stress in a rat model of L-NAME-induced gestational hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Disease Models, Animal; Female; Heme | 2020 |
Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Avoidance Learning; Disease Models, Animal; Mal | 2020 |
Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc.
Topics: Adolescent; Adult; Aged; Animals; Annulus Fibrosus; Antioxidants; Autophagy; Disease Models, Animal; | 2020 |
Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cardiomegaly; Disease Models, Animal; Fi | 2020 |
Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model.
Topics: Animals; Antioxidants; Diet, High-Fat; Disease Models, Animal; Lipid Metabolism; Liver; Melatonin; N | 2020 |
The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Cerebral Infarction; Circadian Rhythm; Disease Mod | 2020 |
Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Cardiotoxicity; Disease Models, Animal; GA | 2021 |
Regulation of Retinal Melanopsin on Lens-induced Myopia in Guinea Pigs.
Topics: Animals; Axial Length, Eye; Blotting, Western; Chromatography, High Pressure Liquid; Contact Lenses; | 2020 |
Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons.
Topics: Analgesics; Animals; Cell Line; Disease Models, Animal; Facial Pain; Hyperalgesia; Melatonin; Nitric | 2020 |
Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex.
Topics: Animals; Behavior, Animal; Cuprizone; Cyclic AMP Response Element-Binding Protein; Disease Models, A | 2020 |
The Melatonin and Enriched Environment Ameliorated Low Protein-Induced Intrauterine Growth Retardation by IGF-1 And mtor Signaling Pathway and Autophagy Inhibition in Rats.
Topics: Animals; Autophagy; Diet, Protein-Restricted; Disease Models, Animal; Female; Fetal Growth Retardati | 2021 |
Screening of sleep assisting drug candidates with a Drosophila model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Disease Models, Animal; Drosoph | 2020 |
Melatonin ameliorates PM
Topics: Acetylation; Animals; Antioxidants; Cardiomyopathies; Cardiotoxicity; Cell Line; Disease Models, Ani | 2021 |
Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Brain; Dimethyldithiocarbamate; Disease Model | 2020 |
Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice.
Topics: Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum | 2020 |
Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Hyperglycemia; Injections, Intraperitoneal; Ma | 2020 |
Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale.
Topics: Animal Scales; Animals; Cell Differentiation; Disease Models, Animal; Extracellular Signal-Regulated | 2020 |
Melatonin Administered before or after a Cytotoxic Drug Increases Mammary Cancer Stabilization Rates in HER2/Neu Mice.
Topics: Anemia; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cyclophosphamide; Diseas | 2020 |
Melatonin stimulates VEGF expression in human granulosa-lutein cells: A potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Humans; Luteal Cells; Melatonin; Ovarian H | 2020 |
Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Inflammation; Injections, Intravenous; Janus | 2020 |
Schizophrenia-like behavior is not altered by melatonin supplementation in rodents.
Topics: Animals; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Melatonin; Rats; Rats, Wista | 2020 |
Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Central Nervous System Depressants; Circadian R | 2020 |
The effect of the "segment" of spinal cord injury on the activity of the nucleotide-binding domain-like receptor protein 3 inflammasome and response to hormonal therapy.
Topics: Animals; CARD Signaling Adaptor Proteins; Caspase 1; Disease Models, Animal; Down-Regulation; Drug A | 2021 |
Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits.
Topics: Animals; Antioxidants; Cellulose; Disease Models, Animal; Drug Compounding; Melatonin; Microscopy, E | 2020 |
Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens.
Topics: Animals; Anti-Bacterial Agents; Bacterial Outer Membrane; Cell Membrane Permeability; Colistin; Dise | 2020 |
Melatonin promotes regeneration of injured motor axons via MT
Topics: Animals; Axons; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; | 2021 |
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CREB-Binding Prot | 2021 |
Topics: Acute Coronary Syndrome; Adolescent; Adsorption; Adult; Aged; Animals; Aspergillus; Aspergillus oryz | 2021 |
Melatonin attenuates branch chain fatty acid induced apoptosis mediated neurodegeneration.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Cell Line, Tumor; Cell Survival; Cerebellum; Cer | 2021 |
Cyst Reduction by Melatonin in a Novel
Topics: Animals; Animals, Genetically Modified; Biomarkers; Cysts; Disease Models, Animal; Disease Susceptib | 2020 |
Melatonin improves periodontitis-induced kidney damage by decreasing inflammatory stress and apoptosis in rats.
Topics: Alveolar Bone Loss; Animals; Apoptosis; Disease Models, Animal; Kidney; Male; Melatonin; Oxidative S | 2021 |
Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway.
Topics: Angiotensin II; Animals; Antioxidants; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Anima | 2020 |
A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma.
Topics: Acetamides; Animals; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Dise | 2020 |
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Melatonin; Neuralgia; Neuroinflammatory Diseases; Rats; Rats, Sprag | 2021 |
Effects of Melatonin and Adrenomedullin in Reducing the Cardiotoxic Effects of Doxorubicin in Rats.
Topics: Action Potentials; Adrenomedullin; Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotoxicity; | 2021 |
Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Male; Mela | 2021 |
Effect of Electroacupuncture on Neurological Deficit and Activity of Clock and Bmal1 in Cerebral Ischemic Rats.
Topics: Animals; ARNTL Transcription Factors; Cerebral Cortex; CLOCK Proteins; Cytokines; Disease Models, An | 2020 |
Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases.
Topics: Animals; Bone Marrow Cells; Bone Neoplasms; Bone Resorption; Cell Differentiation; Disease Models, A | 2021 |
Melatonin Alleviates Cardiac Dysfunction Via Increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis.
Topics: Acetylation; Animals; Autophagy; Beclin-1; Cells, Cultured; Disease Models, Animal; Heart Diseases; | 2021 |
Synergic effect of combined cyclosporin and melatonin protects the brain against acute ischemic reperfusion injury.
Topics: Animals; Apoptosis; Brain; Cell Line, Tumor; Cyclosporine; Disease Models, Animal; Drug Synergism; D | 2021 |
Effect of a Freezing Medium Containing Melatonin on Markers of Pre-meiotic and Post-meiotic Spermatogonial Stem Cells (SSCs) After Transplantation in an Azoospermia Mouse Model Due to Testicular Torsion.
Topics: Adult Germline Stem Cells; Animals; Azoospermia; Cells, Cultured; Cryopreservation; Culture Media; D | 2021 |
Role of melatonin in the dynamics of acute spinal cord injury in rats.
Topics: Animals; Apoptosis; Biomarkers; Disease Models, Animal; Disease Susceptibility; Gene Expression; Imm | 2021 |
Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Autophagy-Re | 2021 |
Combined melatonin and adrenocorticotropic hormone treatment attenuates N-methyl-d-aspartate-induced infantile spasms in a rat model by regulating activation of the HPA axis.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Hum | 2021 |
Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Blotting, Western; Cell Survival; Disease Models, Anima | 2021 |
Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia.
Topics: Animals; Brain; Disease Models, Animal; Female; Malondialdehyde; Melatonin; Oxidative Stress; Placen | 2021 |
Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer.
Topics: Angiogenesis Modulating Agents; Animals; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; | 2021 |
Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway.
Topics: Animals; Disease Models, Animal; Humans; Liver; Male; Melatonin; NF-kappa B; NF-KappaB Inhibitor alp | 2021 |
Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Arterial Pressure; Cyclooxygenase 1; Cyclooxygen | 2021 |
Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in females.
Topics: Animals; Apoptosis; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Drug Synergism; Female | 2021 |
Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction.
Topics: Animals; Antioxidants; Autophagy; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; | 2021 |
Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells.
Topics: Animals; Aorta; Atherosclerosis; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelium, | 2021 |
Therapeutic effects of melatonin on an ovalbumin-induced allergic rhinitis model in rats.
Topics: Aluminum Hydroxide; Animals; Antioxidants; Disease Models, Animal; Goblet Cells; Immunoglobulin E; I | 2021 |
Melatonin Improves Reduced Activities of Membrane ATPases and Preserves Ultrastructure of Gray and White Matter in the Rat Brain Ischemia/Reperfusion Model.
Topics: Adenosine Triphosphatases; Animals; Brain Ischemia; Disease Models, Animal; Gray Matter; Melatonin; | 2021 |
An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis.
Topics: Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Disease Progression; Female; Gene | 2021 |
Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro.
Topics: Acute Disease; Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Interl | 2021 |
Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Lung; Melatonin; M | 2021 |
[Pathogenetically oriented approach to prevention of retinopathy of prematurity (experimental study)].
Topics: Animals; Animals, Newborn; Disease Models, Animal; Humans; Infant, Newborn; Melatonin; Rats; Rats, W | 2021 |
Treatment with melatonin ameliorates febrile convulsion via modulating the MEG3/miR‑223/PTEN/AKT signaling pathway.
Topics: Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulati | 2021 |
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene | 2021 |
Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
Topics: Animals; Aromatase Inhibitors; Blood Glucose; Cell Proliferation; Cricetinae; Disease Models, Animal | 2021 |
Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Female; Hyperplasia; Immunohistochemistry; Mamm | 2021 |
Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota.
Topics: Animals; Antioxidants; Colitis; Corticosterone; Disease Models, Animal; Gastrointestinal Microbiome; | 2021 |
Melatonin pretreatment does not modify extrasystolic burden in the rat ischemia-reperfusion model.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Electrocardiography; Heart Rate; Male; Mela | 2021 |
Norepinephrine May Oppose Other Neuromodulators to Impact Alzheimer's Disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Chem | 2021 |
The lncRNA H19/miR-541-3p/Wnt/β-catenin axis plays a vital role in melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells.
Topics: Adipogenesis; Animals; beta Catenin; Cell Differentiation; Cells, Cultured; Disease Models, Animal; | 2021 |
Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Cardiomyopathies; Disease Models, Animal; Huma | 2021 |
Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1.
Topics: Adult; Animals; Apoptosis; Cell Proliferation; Circadian Rhythm; Disease Models, Animal; Endometrium | 2021 |
Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis.
Topics: Animals; Cell Line; Disease Models, Animal; Fibrosis; Humans; Kidney; Kidney Function Tests; Male; M | 2021 |
Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Inflammasomes; Male; Melatonin | 2021 |
Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury.
Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Cells, Cultured; Disease Models, Animal; Fem | 2017 |
The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model.
Topics: Animals; Disease Models, Animal; Melatonin; Random Allocation; Rats, Sprague-Dawley; Scoliosis; Tryp | 2017 |
Neuroprotective effect of melatonin on soluble Aβ
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; | 2017 |
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Gene Expression Regulation; Immunoglo | 2017 |
Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats.
Topics: Adherens Junctions; Animals; Animals, Newborn; Blood-Brain Barrier; Brain Injuries; Disease Models, | 2017 |
Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Cell Survival; Disease Models, Animal; Ferric Comp | 2017 |
Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Dementia, Vascular; Disease Models, Animal | 2016 |
Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.
Topics: Acetylation; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle | 2017 |
The preventive and curative effects of melatonin against abdominal aortic aneurysm in rats.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortography; Apoptosis; Biomarkers; Calcium C | 2018 |
Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Male; Melatonin; Mice; Neurons; Neurosecretory | 2017 |
Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Interpersonal Relations; Locomotion; Male; Maz | 2017 |
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
Topics: Age Factors; Aging; Animals; Biomarkers; Brain; Circadian Rhythm; Disease Models, Animal; Electropho | 2017 |
Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fatigue; Hypertension; I | 2017 |
Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Ependymoglial Cells; Gl | 2017 |
Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anxiety; Depression; Disease Models, Animal; Glutathione Transferase; Hi | 2017 |
Amelioration of Dalton's lymphoma-induced angiogenesis by melatonin.
Topics: Animals; Blood Vessels; Carcinogenesis; Cell Movement; Cell Proliferation; Disease Models, Animal; E | 2017 |
High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation.
Topics: alpha 1-Antitrypsin; Animals; Biomarkers; Blood Glucose; Blood Proteins; Body Weight; Complement C4; | 2017 |
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cholangitis, Sclerosing; Darkness; Diseas | 2017 |
Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Body Weight; Disease Models, Anim | 2017 |
Pretreatment with melatonin protects against cyclophosphamide-induced oxidative stress and renal damage in mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cyclophosphamide; Disease Models, Animal; | 2017 |
Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies.
Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Disease Models, Animal; Drug Evaluation, Precli | 2017 |
Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.
Topics: Animals; Animals, Newborn; Brain; Catalase; Cell Proliferation; Cognition; Conditioning, Psychologic | 2017 |
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.
Topics: Animals; Bile Ducts; Cell Proliferation; Central Nervous System Depressants; Cholestasis; Disease Mo | 2017 |
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Fibrosis; Heart | 2017 |
Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury.
Topics: Animals; Annexin A5; Antioxidants; Apoptosis; Benzimidazoles; Brain Edema; Brain Injuries; Carbocyan | 2018 |
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats.
Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Diseas | 2017 |
Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia.
Topics: Amnesia; Animals; Choline O-Acetyltransferase; Cognition; Cognitive Dysfunction; Disease Models, Ani | 2018 |
Melatonin alters amino acid metabolism and inflammatory responses in colitis mice.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Dextran Sulfate; Disease Model | 2017 |
Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electroretinography; Melatonin; Mice; Mice, Inbre | 2017 |
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; | 2017 |
Melatonin ameliorates Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Cognition Disorders; | 2018 |
Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Male; Melatoni | 2017 |
Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.
Topics: Adrenal Cortex Hormones; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimenta | 2017 |
Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model.
Topics: Animals; Disease Models, Animal; Inhibins; Male; Melatonin; Oxidative Stress; Rats; Testicular Disea | 2017 |
Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model.
Topics: Animals; Apoptosis; Autoantibodies; Cytokines; Disease Models, Animal; Female; Fibrosis; Inflammatio | 2018 |
Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy.
Topics: Animals; Apoptosis; Biomarkers; Blood Glucose; Diabetic Cardiomyopathies; Disease Models, Animal; En | 2018 |
Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment.
Topics: Acetamides; Animals; Antidepressive Agents; Circadian Rhythm; CLOCK Proteins; Depression; Disease Mo | 2018 |
Comparison of the neuroprotective effects of brimonidine tartrate and melatonin on retinal ganglion cells.
Topics: Animals; Antioxidants; Apoptosis; Brimonidine Tartrate; Disease Models, Animal; Glaucoma; Intraocula | 2018 |
Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model.
Topics: Actins; Animals; Antioxidants; Collagen Type I; Disease Models, Animal; Drug Evaluation, Preclinical | 2018 |
Does the administration of melatonin during post-traumatic brain injury affect cytokine levels?
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Anim | 2018 |
D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway.
Topics: Animals; Butadienes; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; | 2018 |
Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model.
Topics: Animals; Anticonvulsants; Cytokines; Disease Models, Animal; Interleukin-10; Interleukin-1beta; Inte | 2017 |
Misaligned Feeding May Aggravate Pain by Disruption of Sleep-Awake Rhythm.
Topics: Activity Cycles; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cycl | 2018 |
Development and in vivo evaluation of a novel lyophilized formulation for the treatment of hemorrhagic shock.
Topics: 3-Hydroxybutyric Acid; Animals; Chemistry, Pharmaceutical; Dimethyl Sulfoxide; Disease Models, Anima | 2018 |
Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen.
Topics: Animals; Anticarcinogenic Agents; Bile Duct Neoplasms; Cholangiocarcinoma; Cricetinae; Cytokines; Di | 2018 |
Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Disease Models, Animal; I-kappa B Kinase; Inflammation; | 2018 |
Melatonin prevented spatial deficits and increases in brain asymmetric dimethylarginine in young bile duct ligation rats.
Topics: Amidohydrolases; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Hep | 2018 |
Mesenchymal stem cells pretreated with melatonin ameliorate kidney functions in a rat model of diabetic nephropathy.
Topics: Allografts; Animals; Diabetic Nephropathies; Disease Models, Animal; Kidney; Male; Melatonin; Mesenc | 2018 |
Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Model | 2018 |
Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, A | 2018 |
Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis.
Topics: Animals; Baclofen; Biomarkers; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Exp | 2018 |
Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland.
Topics: Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Hyperthyroidism; Hypothyroidism; L | 2018 |
Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1.
Topics: Animals; Disease Models, Animal; Inositol 1,4,5-Trisphosphate Receptors; Male; MAP Kinase Signaling | 2018 |
Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice.
Topics: Animals; Bacteroidetes; Colitis; Disease Models, Animal; Firmicutes; Gastrointestinal Microbiome; Hu | 2018 |
Effects of melatonin on colonic anastomosis healing following chemotherapy in rats.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colon; Colonic Diseases; Disease Models, Anim | 2018 |
Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice.
Topics: Animals; Antioxidants; Cell Cycle Checkpoints; Cell Phone; Comet Assay; Disease Models, Animal; DNA | 2018 |
Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.
Topics: Acetylcholine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Calcium-Binding Protein | 2018 |
Histomorphological changes in the pancreas and kidney and histopathological changes in the liver in male Wistar rats on antiretroviral therapy and melatonin treatment.
Topics: Animals; Anti-Retroviral Agents; Disease Models, Animal; Drug Therapy, Combination; HIV; Immunohisto | 2018 |
Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Catalase; Disease Models, Animal; Exploratory | 2018 |
Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis.
Topics: Amyloid beta-Peptides; Amyloidosis; Animals; Brain; Disease Models, Animal; Humans; Lymph Nodes; Mel | 2018 |
Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring.
Topics: Animals; Disease Models, Animal; Female; Fructose; Gene Expression Regulation; Hypertension; Male; M | 2018 |
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bleomycin; Cell Cycle Proteins; Disease Models, Anima | 2018 |
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bleomycin; Cell Cycle Proteins; Disease Models, Anima | 2018 |
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bleomycin; Cell Cycle Proteins; Disease Models, Anima | 2018 |
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bleomycin; Cell Cycle Proteins; Disease Models, Anima | 2018 |
Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Hypothermia, Induced; Kidney; Male; Malo | 2018 |
Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain.
Topics: Animals; Animals, Newborn; Antioxidants; Calcium-Binding Proteins; Cell Line, Transformed; Central N | 2018 |
[EFFECT OF MELATONIN ON THE GLUTATHIONE ANTIOXIDANT SYSTEM ACTIVITY IN RAT TISSUES UNDER CONDITIONS OF EXPERIMENTAL RHEUMATOID ARTHRITIS.]
Topics: Animals; Antioxidants; Arthritis, Rheumatoid; Disease Models, Animal; Glutathione; Male; Melatonin; | 2016 |
Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Hum | 2018 |
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Cell Line, Tumor; Disease Models, Animal; Humans; M | 2018 |
Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish.
Topics: Adipocytes; Adipose Tissue; Animals; Appetite; Body Mass Index; Brain Chemistry; Cell Count; Cell Si | 2018 |
Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; 3-Hydroxybutyric Acid; Animals; Dimethyl Sulfoxide; Disease Model | 2018 |
THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Topics: Acute Disease; Animals; Cytoprotection; Disaccharides; Disease Models, Animal; Male; Melatonin; Panc | 2018 |
Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder.
Topics: Animals; Anti-Inflammatory Agents; Cognition; Cognitive Dysfunction; Cyclic AMP Response Element-Bin | 2018 |
Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?
Topics: Animals; Behavior Rating Scale; Depression; Disease Models, Animal; Epilepsy, Absence; Hippocampus; | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin improves cardiac function in a mouse model of heart failure with preserved ejection fraction.
Topics: Adipokines; Animals; Antioxidants; Apoptosis; Diet, High-Fat; Disease Models, Animal; Heart Failure; | 2018 |
Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Muscle Strength; Neurotoxins; Neurotransmitter Age | 2018 |
Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.
Topics: Animals; Apoptosis; Autophagosomes; Diabetic Cardiomyopathies; Disease Models, Animal; Hepatocyte Gr | 2018 |
Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.
Topics: Animals; Apoptosis; Autophagosomes; Diabetic Cardiomyopathies; Disease Models, Animal; Hepatocyte Gr | 2018 |
Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.
Topics: Animals; Apoptosis; Autophagosomes; Diabetic Cardiomyopathies; Disease Models, Animal; Hepatocyte Gr | 2018 |
Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.
Topics: Animals; Apoptosis; Autophagosomes; Diabetic Cardiomyopathies; Disease Models, Animal; Hepatocyte Gr | 2018 |
The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hindlimb Suspension; Male; Melat | 2018 |
Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Cell Line, Transformed; Dermatitis, A | 2018 |
Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study.
Topics: Animals; Brain; Disease Models, Animal; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Melatonin; Ne | 2019 |
Mitochondrial biogenesis mediated by melatonin in an APPswe/PS1dE9 transgenic mice model.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Male; Maze Learning; Melato | 2018 |
Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway.
Topics: Animals; Apoptosis; Autophagy; Calcinosis; Carbazoles; Cells, Cultured; Chondrocytes; Disease Models | 2019 |
Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress.
Topics: Adipose Tissue; Animals; Cell Proliferation; Cells, Cultured; Cellular Senescence; Chemical and Drug | 2018 |
Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest.
Topics: Adenosine Triphosphate; Animals; Brain Diseases; Cardiopulmonary Resuscitation; Disease Models, Anim | 2018 |
Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice.
Topics: Animals; Autophagy; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fe | 2019 |
Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat.
Topics: Administration, Oral; Animals; Disease Models, Animal; Estrogens; Female; Letrozole; Melatonin; Poly | 2018 |
Melatonin Attenuates Cardiac Reperfusion Stress by Improving OPA1-Related Mitochondrial Fusion in a Yap-Hippo Pathway-Dependent Manner.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Cell Cycle Proteins; Cells, Cultured; Dise | 2019 |
Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs.
Topics: Acetylcysteine; Animals; Cardiomegaly; Cell Line; Disease Models, Animal; Free Radical Scavengers; G | 2019 |
Antidepressant agomelatine attenuates behavioral deficits and concomitant pathology observed in streptozotocin-induced model of Alzheimer's disease in male rats.
Topics: Acetamides; Alzheimer Disease; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Mo | 2019 |
Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy.
Topics: Administration, Topical; Animals; Axotomy; Central Nervous System Depressants; Dexamethasone; Diseas | 2019 |
Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Drug Compounding; D | 2018 |
Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling.
Topics: Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Female; Melatonin; MicroR | 2019 |
Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma.
Topics: Animals; Dexamethasone; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Dr | 2019 |
Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway.
Topics: Administration, Intravenous; Animals; Ceruletide; Disease Models, Animal; Humans; Inflammation Media | 2019 |
Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Lung Injury; Male; Melatonin; Mice; Mice, Inb | 2019 |
Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.
Topics: Adrenal Glands; Animals; Catecholamines; Chronic Disease; Depression; Disease Models, Animal; Gene E | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia.
Topics: Acetyl-CoA Carboxylase; Animals; Antioxidants; Carnitine O-Palmitoyltransferase; Cholesterol; Choles | 2019 |
Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Melatonin; Mice; Mice, Mutant Strains; Nuclear Recept | 2019 |
Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model.
Topics: Animals; Autoantibodies; Cell Proliferation; Disease Models, Animal; Female; Humans; Melatonin; Mice | 2019 |
Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research.
Topics: Animals; Disease Models, Animal; Germany; Melatonin; Pancreas; Pancreatitis; Physical Fitness; Survi | 2019 |
Protective Effect of Melatonin on Cisplatin-induced Ototoxicity in Rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cisplatin; Disease Models, An | 2019 |
Targeting miR-193a-AML1-ETO-β-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation.
Topics: Animals; Apoptosis; beta Catenin; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Self Ren | 2019 |
Melatonin-pretreated adipose-derived mesenchymal stem cells efficeintly improved learning, memory, and cognition in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Avoidance Learning; Cognition; Dise | 2019 |
Treatment with melatonin and selenium attenuates docetaxel-induced apoptosis and oxidative injury in kidney and testes of mice.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Disease Models, Animal; Docetaxel; Drug The | 2019 |
Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Fetal Diseases; Hemodynamics; Humans; Immun | 2019 |
Melatonin appears to protect against steroidogenic collapse in both mice fed with high-fat diet and H
Topics: Animals; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Diet, High-Fat; Disease Models, Animal; | 2019 |
Melatonin attenuates white matter damage after focal brain ischemia in rats by regulating the TLR4/NF-κB pathway.
Topics: Animals; Brain; Brain Ischemia; Diffusion Tensor Imaging; Disease Models, Animal; Infarction, Middle | 2019 |
Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome.
Topics: Animals; Antioxidants; Arterial Pressure; Bile Ducts; Blood Gas Analysis; Catalase; Disease Models, | 2019 |
The effects of high-fructose corn syrup consumption on testis physiopathology-The ameliorative role of melatonin.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; High Fructose Corn Syrup; Humans; Infertili | 2019 |
The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Colon; Diet, High-Fat; Disease Models, Animal; Dysbios | 2019 |
Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model.
Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Inflammation; Lipopolysaccharides; Melatonin; | 2019 |
Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Hemorrhage; Deubiquitinating Enzymes; Disease Models, A | 2019 |
Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils.
Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Extracellular Traps; Host-Pathogen Interacti | 2019 |
Effect of melatonin on Aβ42 induced changes in the mitochondrial function related to Alzheimer's disease in Drosophila melanogaster.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Dise | 2019 |
Infusion of Melatonin Into the Paraventricular Nucleus Ameliorates Myocardial Ischemia-Reperfusion Injury by Regulating Oxidative Stress and Inflammatory Cytokines.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Inflammation Med | 2019 |
Mitigation of Radiation-Induced Lung Pneumonitis and Fibrosis Using Metformin and Melatonin: A Histopathological Study.
Topics: Animals; Antioxidants; Disease Models, Animal; Melatonin; Metformin; Mice; Protective Agents; Radiat | 2019 |
Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Ki | 2013 |
Function of the hypothalamo-neurohypophysial system in rats with myocardial infarction is modified by melatonin.
Topics: Animals; Arginine Vasopressin; Disease Models, Animal; Feedback, Physiological; Hypothalamo-Hypophys | 2012 |
Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia.
Topics: Animals; Brain; Disease Models, Animal; Female; Fetal Hypoxia; Fetus; Hypoxia, Brain; Immunohistoche | 2012 |
Effects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized rats.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Disease Models, Animal; Drug Therapy, Combination; E | 2013 |
Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis.
Topics: Analysis of Variance; Animals; Arginine; Capsaicin; Digestive System Surgical Procedures; Disease Mo | 2013 |
Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Antioxidants; Caspase 3; Cell Death; C | 2013 |
Melatonin protects against ischemic heart failure in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Heart Failure; M | 2013 |
Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Motor Activity; Neuroprotective Agents; Rats; Rats | 2013 |
The effects of melatonin on intestinal adaptation in a rat model of short bowel syndrome.
Topics: Adaptation, Physiological; Animals; Apoptosis; Disease Models, Animal; DNA; Ileum; Intestinal Mucosa | 2014 |
Melatonin, given at the time of reperfusion, prevents ventricular arrhythmias in isolated hearts from fructose-fed rats and spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Fructose; Hypertension; | 2013 |
Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin.
Topics: Animals; Antioxidants; Apoptosis; Caliciviridae Infections; Disease Models, Animal; Endoplasmic Reti | 2013 |
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat.
Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste | 2013 |
Photoperiod affects the diurnal rhythm of hippocampal neuronal morphology of Siberian hamsters.
Topics: Animals; ARNTL Transcription Factors; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Cr | 2013 |
Use of thiamine pyrophosphate to prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Infertility, Female; Melatonin; Ovarian Disea | 2013 |
Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism.
Topics: Analysis of Variance; Animals; Antioxidants; Autistic Disorder; Behavior, Animal; Calcium-Calmodulin | 2014 |
Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.
Topics: Animals; Antioxidants; Apoptosis; Cell Cycle; Disease Models, Animal; Gene Expression Regulation; In | 2013 |
Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin.
Topics: Acute-Phase Reaction; Animals; Antioxidants; Ascorbic Acid; Circadian Rhythm; Darkness; Disease Mode | 2013 |
[Potential of melatonin for prevention of age-related macular degeneration: experimental study].
Topics: Aging; Animals; Antioxidants; Disease Models, Animal; Follow-Up Studies; Macular Degeneration; Male; | 2013 |
The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.
Topics: Analysis of Variance; Animals; Antioxidants; Cytosol; Disease Models, Animal; Glutathione; Lipid Per | 2014 |
Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indenes; Interleukin-10; Interleu | 2014 |
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice.
Topics: Animals; Behavior, Animal; Chronic Disease; Circadian Rhythm; Circadian Rhythm Signaling Peptides an | 2014 |
Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Indoles; | 2014 |
Melatonin prevents experimental preterm labor and increases offspring survival.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Female; Lipopolysaccharides; Melatonin; Mice; Mic | 2014 |
Attenuation of mania-like behavior in Na(+),K(+)-ATPase α3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Anim | 2014 |
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi | 2013 |
Antioxidant potential of melatonin enhances the response to L-dopa in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-parkinsonian mice.
Topics: Animals; Antioxidants; Antiparkinson Agents; Basal Ganglia; Behavior, Animal; Carbidopa; Catalase; D | 2013 |
Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epile
Topics: Animals; Antioxidants; Behavior, Animal; Blood Pressure; Body Weight; Brain; Circadian Rhythm; Disea | 2014 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats.
Topics: Administration, Oral; Animals; Antioxidants; Diabetes Mellitus; Diet; Disease Models, Animal; Female | 2014 |
Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Electromagnetic Fields; Lens, Crystalline; Male; Mela | 2014 |
Effect of a combined treatment with erythropoietin and melatonin on renal ischemia reperfusion injury in male rats.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Drug T | 2014 |
Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus.
Topics: Animals; Autophagy; Caliciviridae Infections; Disease Models, Animal; Hemorrhagic Disease Virus, Rab | 2014 |
Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease.
Topics: Animals; Convulsants; Dendritic Spines; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2014 |
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Aquaporin 4; Blotting, Western; Brain Edema; Brain Ischemia; Calci | 2014 |
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; | 2014 |
Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats.
Topics: Aldehydes; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Antioxidants; Brain Injuries; | 2014 |
Melatonin dietary supplement as an anti-aging therapy for age-related bone loss.
Topics: Aging; Animals; Antioxidants; Bone and Bones; Bone Density; Dietary Supplements; Disease Models, Ani | 2014 |
[The aging particularities of bone marrow composition, pineal gland and thymus functions in mice of different lines].
Topics: Aging; Animals; Bone Marrow Cells; Disease Models, Animal; Fibroblasts; Macrophages; Male; Melatonin | 2013 |
Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Disease Models, Animal; Gene Expression | 2014 |
Melatonin protects testes against lithium-pilocarpine-induced temporal lobe epilepsy in rats: a time course study.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Male; Melatonin; Piloc | 2015 |
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; M | 2014 |
Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease.
Topics: Acetamides; Animals; Benzaldehydes; Disease Models, Animal; Female; Huntington Disease; Male; Maze L | 2014 |
Melatonin reduces inflammation and recovers endogenous ghrelin in acute necrotizing pancreatitis in rats.
Topics: Animals; Cytokines; Disease Models, Animal; Gastric Mucosa; Ghrelin; Inflammation Mediators; Interle | 2014 |
Chronic exposure to aluminum and melatonin through the diet: neurobehavioral effects in a transgenic mouse model of Alzheimer disease.
Topics: Aluminum; Alzheimer Disease; Animals; Anti-Anxiety Agents; Citric Acid; Diet; Disease Models, Animal | 2014 |
Evaluation of spatial memory and locomotor activity during hypercortisolism induced by the administration of dexamethasone in adult male rats.
Topics: Adrenocortical Hyperfunction; Animals; Antioxidants; Ascorbic Acid; Cholinergic Antagonists; Dexamet | 2015 |
Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Chromatography, High Pressure Liquid; Disease Model | 2014 |
Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis.
Topics: Animals; Antioxidants; Cuprizone; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulati | 2014 |
[Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis].
Topics: Animals; Circadian Rhythm; Delta Sleep-Inducing Peptide; Dermatitis, Contact; Disease Models, Animal | 2014 |
Anti-inflammatory activities of melatonin derivatives in lipopolysaccharide-stimulated RAW 264.7 cells and antinociceptive effects in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Rela | 2014 |
Impact of light/dark cycle patterns on oxidative stress in an adriamycin-induced nephropathy model in rats.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Doxorubicin; Hyperlipidemias; Kidney D | 2014 |
Melatonin improves functional outcome via inhibition of matrix metalloproteinases-9 after photothrombotic spinal cord injury in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Matrix Metalloproteinase 2; Matrix Metallopro | 2014 |
The effects of melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions.
Topics: Animals; Antioxidants; Caffeic Acids; Disease Models, Animal; Fracture Fixation, Intramedullary; Fra | 2014 |
Rapidly alternating photoperiods disrupt central and peripheral rhythmicity and decrease plasma glucose, but do not affect glucose tolerance or insulin secretion in sheep.
Topics: Animals; Biomarkers; Blood Glucose; Body Temperature Regulation; Body Weight; Chronobiology Disorder | 2014 |
The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Catalase; Cerebral Cortex; Disease Models, Animal; Glut | 2014 |
Enhanced electrical responsiveness in the cerebral cortex with oral melatonin administration after a small hemorrhage near the internal capsule in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cells, Cultured; Cerebral Cortex; Cerebral Hemorrhage; | 2014 |
Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Circadian Rhythm; Disease Models, Animal | 2014 |
Potential role of some oxidant/antioxidant status parameters in prefrontal cortex of rat brain in an experimental psychosis model and the protective effects of melatonin.
Topics: Animals; Antioxidants; Disease Models, Animal; Dizocilpine Maleate; Glutathione Peroxidase; Male; Ma | 2014 |
Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Antioxidants; Ceruletide; Cytoprotection; Disease Models, Animal; Female; Gl | 2014 |
Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process.
Topics: Aging; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cytochrome P-450 CYP1A2; | 2014 |
Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation.
Topics: Animals; Antioxidants; Aqueous Humor; Cricetinae; Dinoprost; Dinoprostone; Disease Models, Animal; E | 2014 |
Melatonin improve the sperm quality in forced swimming test induced oxidative stress in nandrolone treated Wistar rats.
Topics: Anabolic Agents; Animals; Antioxidants; Disease Models, Animal; Humans; Male; Melatonin; Nandrolone; | 2014 |
Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats.
Topics: Animals; Apoptosis; Blotting, Western; Cytokines; Dentate Gyrus; Disease Models, Animal; Enzyme-Link | 2014 |
The effect of melatonin on procarbazine induced testicular toxicity on rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cytoprotection; Disease Models, Animal; Follicle Stimu | 2014 |
Sleep disorders and inflammatory disease activity: chicken or the egg?
Topics: Animals; C-Reactive Protein; Circadian Rhythm; Clinical Trials as Topic; Colitis, Ulcerative; Crohn | 2015 |
Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression.
Topics: Animals; Brain; Depression; Disease Models, Animal; Drinking Behavior; Drugs, Chinese Herbal; Gene E | 2015 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Disease Models, Animal; Female; Glucose Tolerance Test; Insulin Resistance; Lipid Metabolis | 2014 |
Protective effect of melatonin on cigarette smoke-induced restenosis in rat carotid arteries after balloon injury.
Topics: Angioplasty, Balloon; Animals; Anti-Inflammatory Agents; Blotting, Western; Carotid Arteries; Caroti | 2014 |
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma in Situ; Carci | 2014 |
Effects of intracoronary melatonin on ischemia-reperfusion injury in ST-elevation myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Animals; Antioxidants; Disease Models, Animal; Female; Magnetic Reso | 2016 |
Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits.
Topics: Animals; Aorta; Atherosclerosis; Capillary Permeability; Disease Models, Animal; Extracellular Signa | 2015 |
Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspases; Disease Models, Animal; Hypoxia; Hypoxia | 2015 |
Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2015 |
Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Galactose; Inflammat | 2015 |
Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; CLOCK Proteins; Cryptochromes; Disease Model | 2015 |
Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Electron Spin Resonance Spectrosco | 2014 |
Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Circadian Clocks; Circadian Rhythm; Disease Models | 2015 |
Beneficial effects of melatonin in a rat model of sporadic Alzheimer's disease.
Topics: Administration, Oral; Aging, Premature; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, | 2015 |
Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases.
Topics: Animals; Antioxidants; Disease Models, Animal; Endometriosis; Female; Injections, Intraperitoneal; M | 2015 |
Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential.
Topics: Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2014 |
Melatonin leads to axonal regeneration, reduction in oxidative stress, and improved functional recovery following sciatic nerve injury.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Electromyography; Female; Glutathione Perox | 2015 |
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col | 2016 |
Melatonin improves experimental colitis with sleep deprivation.
Topics: Animals; Body Weight; Colitis; Cytokines; Disease Models, Animal; Gene Expression Profiling; Inflamm | 2015 |
Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cytokines; Disease Models, Animal; Female; Gene Expr | 2015 |
A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Topics: Acute Lung Injury; Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Li | 2015 |
[Extracellular matrix remodeling myocardium of the left ventricle rats with experimental heart failure after perindopril and melatonin administration].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Disease Models, Animal; Extracellul | 2014 |
Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cyclooxygen | 2015 |
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder, Major | 2015 |
Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Male | 2015 |
The protective properties of melatonin against aluminium-induced neuronal injury.
Topics: Aluminum Chloride; Aluminum Compounds; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Protei | 2015 |
Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Brain; Coumarins; Dis | 2015 |
Melatonin prevents hyperglycemia in a model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Disease Models, Anim | 2015 |
The effects of aminoguanidine, methylprednisolone, and melatonin on nerve recovery in peripheral facial nerve neurorrhaphy.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Facial Nerve Diseases; Female; Guanidines; Melat | 2015 |
Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Hippocampus; Male; Melato | 2015 |
Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Body Weight; Disease Models, Animal; Docosahexa | 2016 |
Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption.
Topics: Acetamides; Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Aminopyridines; Animals | 2015 |
The investigation of melatonin effect on liver antioxidant and oxidant levels in fructose-mediated metabolic syndrome model.
Topics: Animals; Antioxidants; Disease Models, Animal; Fructose; Insulin Resistance; Liver; Male; Melatonin; | 2015 |
The potential role of melatonin on sleep deprivation-induced cognitive impairments: implication of FMRP on cognitive function.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antioxidants; Brain; Cell Survival; Cells, Cultured | 2015 |
Melatonin protects ADSCs from ROS and enhances their therapeutic potency in a rat model of myocardial infarction.
Topics: Adipose Tissue; Angiogenesis Inducing Agents; Animals; Antioxidants; Apoptosis; Cell Survival; Cells | 2015 |
Pineal Melatonin in a Sub-chronic Tryptophan Depletion Female Rat Model of Treatment-resistant Depression.
Topics: Aldosterone; Animals; Corticosterone; Depressive Disorder, Treatment-Resistant; Disease Models, Anim | 2015 |
Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Disease Models, Animal; Gene Expression Profiling; Gene Ex | 2015 |
Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anxiety; Disease | 2015 |
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis.
Topics: Animals; Antiviral Agents; Ascorbic Acid; Brain; Cell Line, Tumor; Disease Models, Animal; Dose-Resp | 2015 |
Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal | 2015 |
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Cardiotonic Agents; Cell Line; Chro | 2015 |
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Autophagy; Cyclin-Dependent | 2015 |
The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination.
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Rela | 2016 |
Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer.
Topics: Animals; Antioxidants; Carcinogens; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combinatio | 2016 |
Fetal undernutrition is associated with perinatal sex-dependent alterations in oxidative status.
Topics: Animals; Animals, Newborn; Antioxidants; Biomarkers; Blood Pressure; Body Weight; Catalase; Disease | 2015 |
Melatonin Attenuates Memory Impairment, Amyloid-β Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer's Disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anim | 2015 |
Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; bcl-X Protein; Blood-Brain Barrier; Brain; Brain | 2015 |
Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats.
Topics: Animals; Antioxidants; Biological Availability; Brain; Central Nervous System Depressants; Disease M | 2015 |
Effect of melatonin on sleep disorders in a monkey model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Central Nervous System Depressants; Disease Models, Animal; Levodopa; | 2015 |
Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus.
Topics: Altitude Sickness; Animals; Antioxidants; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia; M | 2015 |
Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo.
Topics: Animals; Chick Embryo; Disease Models, Animal; Female; Fetal Growth Retardation; Humans; Melatonin; | 2016 |
Melatonin prevents kidney injury in a high salt diet-induced hypertension model by decreasing oxidative stress.
Topics: Animals; Disease Models, Animal; Hypertension; Male; Melatonin; Oxidative Stress; Rats; Rats, Inbred | 2016 |
The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage.
Topics: Animals; Apoptosis; Brain Injuries; Cytokines; Disease Models, Animal; Jaundice; Melatonin; Nerve Ti | 2016 |
No improvement of neuronal metabolism in the reperfusion phase with melatonin treatment after hypoxic-ischemic brain injury in the neonatal rat.
Topics: Acetates; Animals; Animals, Newborn; Antioxidants; Astrocytes; Brain Injuries; Brain Ischemia; Disea | 2016 |
Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal rats.
Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Exci | 2015 |
Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Disease Models, Animal; Down-Regulation; | 2016 |
Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats.
Topics: Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Antioxidants; Aspartate Aminotransfera | 2016 |
Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Hy | 2015 |
The effect of melatonin on spinal cord after ischemia in rats.
Topics: Animals; Antioxidants; Caspase 3; Disease Models, Animal; Gene Expression Regulation; Glutathione; M | 2016 |
Time-dependent miR-16 serum fluctuations together with reciprocal changes in the expression level of miR-16 in mesocortical circuit contribute to stress resilient phenotype in chronic mild stress - An animal model of depression.
Topics: Anhedonia; Animals; Biomarkers; Chronic Disease; Corticosterone; Depressive Disorder; Dietary Sucros | 2016 |
Short photoperiod condition increases susceptibility to stress in adolescent male rats.
Topics: Aging; Anhedonia; Animals; Circadian Rhythm; Corticosterone; Disease Models, Animal; Disease Suscept | 2016 |
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model.
Topics: Aging; Aging, Premature; Animals; Apoptosis; Biomarkers; Disease Models, Animal; Dose-Response Relat | 2016 |
Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise.
Topics: Animals; Biomarkers; Disease Models, Animal; Inflammation; Melatonin; Mice; Muscle, Skeletal; Perfor | 2015 |
Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Echocardiography; Enzyme-Linked Im | 2016 |
Perindopril Attenuates Lipopolysaccharide-Induced Amyloidogenesis and Memory Impairment by Suppression of Oxidative Stress and RAGE Activation.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Angiotensin-Converting Enzyme In | 2016 |
[STUDIES OF THE ANTIHYPOXIC AND ANTIAMNESTIC EFFECTS OF MELATONIN IN ANIMALS].
Topics: Amnesia; Animals; Antioxidants; Disease Models, Animal; Hippocampus; Hypoxia; Male; Melatonin; Mice; | 2015 |
Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson's disease.
Topics: Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Immunohistochemistry; Male; Melatoni | 2016 |
Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network.
Topics: Animals; Antioxidants; Disease Models, Animal; Electron Transport; Electron Transport Complex III; M | 2016 |
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Disease Models, Animal; Heme Oxygenase-1; Inflammatio | 2016 |
Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice.
Topics: Animals; Blood Platelets; Calcium; Disease Models, Animal; Fibrinogen; Hemostasis; Hydroxyindoleacet | 2016 |
Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia.
Topics: Animals; Antioxidants; Atherosclerosis; Cholesterol, Dietary; Chronic Disease; Disease Models, Anima | 2016 |
Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease.
Topics: Animals; Antioxidants; beta Catenin; Calnexin; Disease Models, Animal; Disease Progression; Endoplas | 2016 |
Neuroprotective effect of melatonin in experimental optic neuritis in rats.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Lipid Peroxidation; Lipopolysaccharides; Male; Me | 2016 |
Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrho | 2016 |
Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blotting, Western; Disease Models, Animal; Enz | 2016 |
Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor.
Topics: Animals; Circadian Rhythm; Corpus Striatum; Disease Models, Animal; Male; Melatonin; Morphine; Morph | 2016 |
JNK-TLR9 signal pathway mediates allergic airway inflammation through suppressing melatonin biosynthesis.
Topics: Animals; Asthma; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Femal | 2016 |
Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Leu | 2016 |
Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2016 |
The effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in the first SCID-mouse endometriosis-model developed in Turkey.
Topics: Animals; Antioxidants; Disease Models, Animal; Endometriosis; Estradiol; Female; Melatonin; Mice; Mi | 2016 |
Effects of Melatonin on the Cerebellum of Infant Rat Following Kaolin-Induced Hydrocephalus: a Histochemical and Immunohistochemical Study.
Topics: Animals; Animals, Newborn; Apoptosis; Cerebellum; Disease Models, Animal; Double-Blind Method; Glial | 2017 |
Evaluation of Electrophysiological Effects of Melatonin and Alpha Lipoic Acid in Rats with Streptozotocine Induced Diabetic Neuropathy.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Diabetic Neuropathies; Disease Models, Animal; E | 2016 |
Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model.
Topics: Angiotensin II; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Diabetic N | 2016 |
Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome.
Topics: Animals; Antioxidants; Cellular Senescence; Disease Models, Animal; Down Syndrome; Glutathione Perox | 2016 |
Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis.
Topics: Animals; Antioxidants; Disease Models, Animal; Interleukin-1beta; Male; Melatonin; Oxidative Stress; | 2017 |
Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function.
Topics: Animals; Antioxidants; Cytochromes c; Disease Models, Animal; Escape Reaction; Hippocampus; Hypnotic | 2017 |
Comparison of Melatonin, Hypertonic Saline, and Hydroxyethyl Starch for Resuscitation of Secondary Intra-Abdominal Hypertension in an Animal Model.
Topics: Abdomen; Animals; Disease Models, Animal; Female; Hydroxyethyl Starch Derivatives; Hypertension, Por | 2016 |
Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Femal | 2016 |
Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Transplantation; Ce | 2016 |
Elevated intraocular pressure increases melatonin levels in the aqueous humour.
Topics: Adult; Aged; Aged, 80 and over; Animals; Aqueous Humor; Biomarkers; Chromatography, High Pressure Li | 2017 |
Effects of melatonin on spinal cord injury-induced oxidative damage in mice testis.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Glutathione; Glutathio | 2017 |
Quantitative Proteomic Profiling Reveals That Diverse Metabolic Pathways Are Influenced by Melatonin in an in Vivo Model of Ovarian Carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Melatonin; Metabolic Netw | 2016 |
Protective effect of melatonin on soluble Aβ1-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Gliosis; Hippocampus; Male | 2016 |
Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Disease Models, Animal; Edema; Female; Laser-Doppler Flo | 2016 |
PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Inflammation; Melatonin; Mice, | 2017 |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2017 |
Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; In Situ Nick-End Labeling; Melatonin; | 2017 |
Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.
Topics: Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Immunologic Factors; Immunomodulation; | 2017 |
Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression.
Topics: Animals; Apoptosis; Disease Models, Animal; Gene Knockdown Techniques; Male; Melatonin; Mice; Mice, | 2017 |
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression.
Topics: Animals; Antioxidants; Biomarkers; Blotting, Western; Disease Models, Animal; Ethylene Glycol; Gene | 2017 |
IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer.
Topics: Adenocarcinoma; Animals; Cell Differentiation; Cell Line, Tumor; Disease Models, Animal; Enzyme-Link | 2017 |
Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner.
Topics: Animals; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Hyperglycemia; M | 2017 |
Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation.
Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Lipid Peroxidation; Liver; Liver Cirrhos | 2016 |
Exogenous daytime melatonin modulates response of adolescent mice in a repeated unpredictable stress paradigm.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Antioxidants; Behavior, Animal; Biomarkers; Brain; Chroni | 2017 |
Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus.
Topics: Aluminum Oxide; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Ani | 2016 |
Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway.
Topics: Animals; Arsenic Trioxide; Arsenicals; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2017 |
Effect of Melatonin and Calmodulin in an Idiopathic Scoliosis Model.
Topics: Animals; Calmodulin; Disease Models, Animal; Female; Humans; Lighting; Melatonin; Rats; Scoliosis; T | 2016 |
Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Depression; Disease Models, Animal; M | 2017 |
Melatonin attenuates titanium particle-induced osteolysis via activation of Wnt/β-catenin signaling pathway.
Topics: Animals; beta Catenin; Bone Regeneration; Cell Differentiation; Disease Models, Animal; Intercellula | 2017 |
Melatonin inhibits snake venom and antivenom induced oxidative stress and augments treatment efficacy.
Topics: Animals; Antivenins; Disease Models, Animal; Female; Melatonin; Mice; Oxidative Stress; Rabbits; Sna | 2017 |
Potentiation of biological effects of mesenchymal stem cells in ischemic conditions by melatonin via upregulation of cellular prion protein expression.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; Flo | 2017 |
Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression.
Topics: Animals; Antioxidants; Bile Acids and Salts; Blotting, Western; Chromatin Immunoprecipitation; Disea | 2017 |
Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.
Topics: Animals; Antioxidants; Biomarkers; Disease Models, Animal; Gene Expression Regulation, Enzymologic; | 2017 |
Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases.
Topics: Angiotensin II; Animals; Antioxidants; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, West | 2017 |
Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrier Proteins; Cytoprotection; Disease Models, Animal; Drug Th | 2017 |
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Topics: Animals; Anti-Inflammatory Agents; Chloranil; Disease Models, Animal; Extracellular Signal-Regulated | 2017 |
Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: Matrixmetalloproteinases as regulators.
Topics: Aging; Animals; Antioxidants; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Female; M | 2017 |
[Extrapineal melatonin in processes of accelerated and premature aging in rats].
Topics: Aging; Aging, Premature; Animals; Disease Models, Animal; Duodenum; Enterochromaffin Cells; Gamma Ra | 2008 |
Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Ferritins; Gene Expression; Jaundice, Obst | 2008 |
Combination therapy of imipramine and melatonin: additive antidepressant effect in mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Disease Models, Animal; Dose-Response Re | 2008 |
Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions.
Topics: Analysis of Variance; Animals; Cyclosporine; Disease Models, Animal; Erythropoietin; Female; Locomot | 2009 |
The neuroprotective role of melatonin against amyloid beta peptide injected mice.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Disease Models, An | 2008 |
Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Catalase; Curcumin; Disease Models, Animal; Ferric Compo | 2008 |
Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Chemokines; Colitis; Disease Models, Animal; Female; Male; Melatonin; Rats; Trinitrobenzene | 2008 |
Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway.
Topics: Analysis of Variance; Animals; Antioxidants; Cell Line, Transformed; Cell Survival; Disease Models, | 2008 |
[Antioxidants prevent experimental hemiparkinsonism in rats].
Topics: Animals; Antioxidants; Behavior, Animal; Chromans; Disease Models, Animal; Dopamine; Male; Melatonin | 2008 |
Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model.
Topics: Animals; Cytoprotection; Disease Models, Animal; Enteritis; Epithelial Cells; Intestinal Mucosa; Int | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
Effects of melatonin in an experimental model of ventilator-induced lung injury.
Topics: Animals; Disease Models, Animal; Edema; Extracellular Matrix; Gelatinases; Glutathione Peroxidase; I | 2008 |
[Inhibitory effect of melatonin on the expression of nuclear factor-kappaB during acute lung injury in rats].
Topics: Animals; Dexamethasone; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Malondialdehyde; Me | 2008 |
Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Brain Ischemia; Dendrites; Disease Models, Animal; Drug | 2008 |
Therapeutic effect of melatonin in experimental uveitis.
Topics: Animals; Blood-Retinal Barrier; Cricetinae; Cricetulus; Disease Models, Animal; Electroretinography; | 2008 |
The antioxidant effects of melatonin after intracerebral hemorrhage in rats.
Topics: Animals; Antioxidants; Basal Ganglia; Brain Edema; Cerebral Hemorrhage; Collagenases; Disease Models | 2008 |
Long-term effects of melatonin after intracerebral hemorrhage in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Brain Infarction; Cerebral Hemorrhage; Collagenases; Corpus | 2008 |
Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Convulsants; Disease Models, An | 2009 |
Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome.
Topics: Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Fragile X Mental Retardation Protei | 2009 |
Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin.
Topics: Animals; Animals, Newborn; Antioxidants; Cerebral Cortex; Disease Models, Animal; Docosahexaenoic Ac | 2009 |
Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Headache; Immunohistochemistry; In | 2009 |
Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms.
Topics: Analysis of Variance; Animals; Antioxidants; Basilar Artery; Brain; Disease Models, Animal; Lipid Pe | 2009 |
Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.
Topics: Alzheimer Disease; Animals; Antioxidants; Behavior, Animal; Cyclic AMP-Dependent Protein Kinases; Di | 2009 |
The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Female; Intracranial Pressure; | 2008 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr | 2009 |
The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model.
Topics: Animals; Bone Density Conservation Agents; Calmodulin; Chickens; Disease Models, Animal; Dopamine An | 2009 |
Melatonin, a potent regulator of hemeoxygenase-1, reduces cardiopulmonary bypass-induced renal damage in rats.
Topics: Animals; Cardiopulmonary Bypass; Catalase; Disease Models, Animal; Gene Expression; Heme Oxygenase-1 | 2009 |
Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats.
Topics: Animals; Disease Models, Animal; Epididymis; Injections, Intraperitoneal; Male; Melatonin; Rats; Rat | 2010 |
Pinealectomy in the chicken: a good model of scoliosis?
Topics: Animals; Chickens; Disease Models, Animal; Intervertebral Disc; Melatonin; Pineal Gland; Reproducibi | 2009 |
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence.
Topics: Animals; Blindness; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Disease Models, Ani | 2009 |
Effects of melatonin in early brain injury following subarachnoid hemorrhage.
Topics: Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Male | 2008 |
The antioxidant effects of melatonin in surgical brain injury in rats.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Re | 2008 |
Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum.
Topics: Aluminum Compounds; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Diet; Disease Models | 2010 |
Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule.
Topics: Affect; Analysis of Variance; Animals; Anxiety; Circadian Rhythm; Depression; Disease Models, Animal | 2009 |
The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Injections, Intraperitoneal; | 2009 |
Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Ca | 2009 |
Rhythms of serum melatonin in rats with acute spinal cord injury at the cervical and thoracic regions.
Topics: Analysis of Variance; Animals; Blood Pressure; Cervical Vertebrae; Disease Models, Animal; Enzyme-Li | 2010 |
Melatonin reduces cardiac inflammatory injury induced by acute exercise.
Topics: Animals; Cardiomyopathies; Cyclooxygenase 2; Disease Models, Animal; Inflammation; Intercellular Adh | 2009 |
Recent trends in hypertension treatment: perspectives from animal studies.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Disease Models, Animal; Female; Hu | 2009 |
Melatonin prevents cyclosporine-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Disease Models, Animal; Free Radical | 2009 |
Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats.
Topics: Alcohol-Induced Disorders; Animals; Antioxidants; Ascorbic Acid; Catalase; Central Nervous System De | 2009 |
Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model.
Topics: Animals; Body Weight; Cell Count; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Mel | 2010 |
Melatonin prevents peritoneal adhesions in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cecum; Disease Models, Animal; Hydroxyproline; Male; Ma | 2009 |
Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia.
Topics: Animals; Animals, Newborn; Antioxidants; Catalase; Disease Models, Animal; Glutathione Peroxidase; H | 2009 |
Pineal melatonin synthesis is decreased in type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Animals, Genetically Modified; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regu | 2009 |
A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Behavioral Sy | 2010 |
Effects of melatonin and phospholipid on adhesion formation and correlation with vascular endothelial growth factor expression in rats.
Topics: Animals; Antioxidants; Cecum; Cell Adhesion; Disease Models, Animal; Female; Ileum; Melatonin; Phosp | 2009 |
Report from the 2004 AES Annual Meeting. Highlights from the 58th Annual Meeting of the American Epilepsy Society, December 3-7, 2004, New Orleans, LA.
Topics: Animals; Aromatase Inhibitors; Complementary Therapies; Disease Models, Animal; Epilepsy; Gonadal St | 2005 |
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS.
Topics: Amidines; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Kidney; Ki | 2009 |
A randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn model.
Topics: Administration, Oral; Animals; Antioxidants; Disease Models, Animal; Female; Injections, Intraperito | 2010 |
Antioxidant activity of tryptophan in rats under experimental endotoxic shock.
Topics: Animals; Animals, Suckling; Antioxidants; Cytokines; Dietary Supplements; Disease Models, Animal; Fe | 2010 |
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Heart Rate; Interleukin-6; Intestine, | 2011 |
Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis.
Topics: Amylases; Animals; Disease Models, Animal; DNA; Female; Gene Expression Regulation; Immunohistochemi | 2010 |
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Do | 2010 |
The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats.
Topics: Action Potentials; Animals; Antioxidants; Collagen; Disease Models, Animal; Female; Melatonin; Motor | 2011 |
[Effects of melatonin on nociception processes in experimentally model of neurophatic pain].
Topics: Animals; Disease Models, Animal; Male; Melatonin; Nociceptors; Pain Threshold; Rats; Rats, Wistar; R | 2008 |
An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis.
Topics: Animals; Antioxidants; Disease Models, Animal; Ischemia; Male; Melatonin; Penis; Priapism; Rats; Rat | 2010 |
Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Glutathione; Injections, I | 2010 |
Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits.
Topics: Animals; Antioxidants; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked I | 2009 |
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Bile Ducts; Cholestasis, Intrahepatic; Dis | 2010 |
Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model.
Topics: Analysis of Variance; Animals; Blotting, Western; Body Weight; Disease Models, Animal; Drug Synergis | 2010 |
Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Ceruletide; Cytokines; Disease Models, Animal; Gene Exp | 2010 |
Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats.
Topics: Animals; Antioxidants; Basal Ganglia Diseases; Cerebral Hemorrhage; Corpus Striatum; Disease Models, | 2010 |
Melatonin augments expression of the procollagen α1 (I) and α1 (III) genes in the infarcted heart scar of pinealectomized rats.
Topics: Animals; Cells, Cultured; Cicatrix; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type I | 2010 |
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Topics: Analgesics; Animals; Colitis; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Melatonin; N | 2010 |
Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mela | 2010 |
Antioxidants and beneficial microvascular effects: is this the remedy?
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Flavonoids; Humans; Hypert | 2010 |
Effects of melatonin and Pycnogenol on small artery structure and function in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Biomarkers; Cyclooxygenase 2; Disease Models | 2010 |
Exogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute pancreatitis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Disease Models, | 2010 |
Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.
Topics: Alzheimer Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Male; Malondiald | 2011 |
Melatonin's protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Disease Models, Animal; Gerbillinae; Ischemic Attack, | 2010 |
Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Glutath | 2010 |
Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Disease Models, Animal; Endometriosis; Endometrium; Epithe | 2010 |
Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation.
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Inflammation | 2010 |
Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Nerve Regeneration; Neuroprotective Agents; Periph | 2010 |
[Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Lung; Melatonin; p38 Mitogen-Activated Protein K | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; | 2010 |
Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Endometriosis; Endometrium; Female; Malondiald | 2010 |
Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis, Ulcerative; Co | 2011 |
Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy.
Topics: Administration, Topical; Animals; Antioxidants; Disease Models, Animal; Injections; Male; Melatonin; | 2010 |
Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice.
Topics: Animals; Antibodies, Antinuclear; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin | 2010 |
Circadian alteration in neurobiology during protracted opiate withdrawal in rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Brain; Circadian Rhythm; Dis | 2010 |
Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging.
Topics: Aging; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Heart; Heme Oxygenase (Decyclizing) | 2010 |
Potential animal models of seasonal affective disorder.
Topics: Animals; Brain; Cricetinae; Disease Models, Animal; Humans; Melatonin; Rats; Seasonal Affective Diso | 2011 |
The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage.
Topics: Aging; Animals; Antioxidants; Aorta; Caffeic Acids; Catalase; Disease Models, Animal; Drug Evaluatio | 2011 |
RE: Kesik et al: melatonin ameliorates doxorubicin-induced skin necrosis in rats.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Doxorubicin; Melatonin; Necrosis; Rats; Sensiti | 2010 |
Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Avoidance Learning; Brain Injuries; Cerebral Cortex; D | 2011 |
Melatonin promotes fracture healing in the rat model.
Topics: Animals; Disease Models, Animal; Fracture Healing; Fractures, Bone; Male; Malondialdehyde; Melatonin | 2010 |
Melatonin attenuates clock gene cryptochrome1, which may aggravate mouse anti-type II collagen antibody-induced arthritis.
Topics: Animals; Arthritis, Experimental; CLOCK Proteins; Collagen Type II; Cryptochromes; Disease Models, A | 2012 |
Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model.
Topics: Algorithms; Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Drug Co | 2011 |
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; | 2011 |
[The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin].
Topics: Animals; Disease Models, Animal; Male; Melatonin; Pancreas; Pancreatitis, Acute Necrotizing; Rats; R | 2010 |
Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation.
Topics: Acute Disease; Animals; Apoptosis; Atrophy; Disease Models, Animal; Injections, Intraperitoneal; Lig | 2010 |
The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats.
Topics: Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Ani | 2011 |
Estradiol worsens the syndrome of ischemia-reperfusion injury in an experimental lung transplantation model.
Topics: Animals; Antioxidants; Chi-Square Distribution; Deferoxamine; Disease Models, Animal; Estradiol; Gra | 2011 |
Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?
Topics: Analysis of Variance; Animals; Antioxidants; Cell Death; Disease Models, Animal; Hippocampus; Male; | 2011 |
Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy.
Topics: Animals; Antioxidants; Creatinine; Disease Models, Animal; Glutathione; Humans; Isometric Contractio | 2011 |
The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus).
Topics: Acetylserotonin O-Methyltransferase; Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltr | 2011 |
Melatonin reduces the severity of experimental amoebiasis.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Cricetinae; Disease Models, Animal; Entamoeba histolyti | 2011 |
The effect of melatonin and platelet gel on sciatic nerve repair: an electrophysiological and stereological study.
Topics: Animals; Anti-Inflammatory Agents; Blood Platelets; Disease Models, Animal; Electrodiagnosis; Gels; | 2011 |
Pentoxifylline and melatonin in combination with pioglitazone ameliorate experimental non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Body Weight; C | 2011 |
Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.
Topics: Analysis of Variance; Animals; Brain; Central Nervous System Depressants; Clonazepam; Disease Models | 2011 |
Melatonin treatment following stroke induction modulates L-arginine metabolism.
Topics: Animals; Arginine; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; Humans; Male; Melato | 2011 |
Melatonin protects lung mitochondria from aging.
Topics: Adenosine Triphosphate; Administration, Oral; Aging; Animals; Antioxidants; Disease Models, Animal; | 2012 |
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Basal Nucleus of Meynert | 2011 |
Interactive effects of melatonin, exercise and diabetes on liver glycogen levels.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Dietary Supplements; Disease Models, Animal; | 2011 |
Melatonin and beta-glucan alone or in combination inhibit the growth of dunning prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antioxidants; beta-Glucans; Blotting, Western; Disease Models, Animal; Glut | 2011 |
Maternal stress induces adult reduced REM sleep and melatonin level.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Male; Maternal Deprivation; Melatonin; Ra | 2012 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury.
Topics: Analysis of Variance; Animals; Autophagy; Blotting, Western; Body Weight; Disease Models, Animal; Ma | 2012 |
Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Mal | 2012 |
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified | 2012 |
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyp | 2011 |
The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.
Topics: Analysis of Variance; Animals; Brain; Caspase 3; Caspase 9; Cell Death; Cells, Cultured; Disease Mod | 2011 |
Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Male; Melatonin; Morphine Dependence; Pai | 2012 |
Neuroprotective effects of melatonin on the nigrostriatal dopamine system in the zitter rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Cytokines; Disease Models, Animal; Dopamin | 2012 |
Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model.
Topics: Animals; Animals, Newborn; Antioxidants; Cold Temperature; Disease Models, Animal; Drug Evaluation, | 2011 |
Aging and vascular dysfunction: beneficial melatonin effects.
Topics: Aging; Animals; Antioxidants; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endothelium, | 2013 |
Pinealectomy affects bone mineral density and structure--an experimental study in sheep.
Topics: Animals; Biomarkers; Bone Density; Bone Resorption; Disease Models, Animal; Female; Ilium; Melatonin | 2011 |
Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction.
Topics: Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Dietary Supplements; Disease Mode | 2012 |
Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Benzenesulfonates; Caspase 3; CD4-Positive T-Lymphocytes; Colitis | 2013 |
The influence of melatonin and agomelatine on urodynamic parameters in experimental overactive bladder model--preliminary results.
Topics: Acetamides; Animals; Case-Control Studies; Central Nervous System Depressants; Disease Models, Anima | 2011 |
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Humans; Male; Melatonin; Mice; Mice, 129 Strain; | 2012 |
Melatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidney.
Topics: Acute Kidney Injury; Alcoholic Intoxication; Animals; Antioxidants; Ascorbic Acid; Disease Models, A | 2012 |
Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity.
Topics: Animals; Chemical Warfare Agents; Disease Models, Animal; Inflammation; Isothiuronium; Kidney Diseas | 2012 |
Cellular mechanisms of plasmalemmal sealing and axonal repair by polyethylene glycol and methylene blue.
Topics: Animals; Antioxidants; Axons; Axotomy; Calcium; Cell Line, Tumor; Cell Membrane; Disease Models, Ani | 2012 |
Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model.
Topics: Animals; Blotting, Western; Brain Injuries; Disease Models, Animal; Immunohistochemistry; In Situ Ni | 2012 |
An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
Topics: Analysis of Variance; Animals; Antioxidants; Automatism; Blood-Brain Barrier; Convulsants; Disease M | 2012 |
Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures.
Topics: Animals; Bulbo-Spinal Atrophy, X-Linked; Cells, Cultured; Disease Models, Animal; Drosophila; Humans | 2012 |
Histological study of the protective effect of melatonin on neural cells after neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Brain; Brain Infarction; Demyelinating Diseases; D | 2012 |
The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors.
Topics: Animals; Behavior, Animal; Biological Clocks; Circadian Rhythm; Cryptochromes; Disease Models, Anima | 2012 |
[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytoprotection; D | 2012 |
Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Capillary Permeability; Cytoprotection; Disease Models, An | 2012 |
Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs.
Topics: Acute Lung Injury; Airway Resistance; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bi | 2012 |
Preischemic treatment with melatonin attenuates liver reperfusion-induced impairment of cardiac function.
Topics: Animals; Antioxidants; Biomarkers; Cardiac Catheterization; Creatine Kinase, MB Form; Disease Models | 2012 |
Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
Topics: Animals; Calcium; Cell Death; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; G | 2012 |
Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway.
Topics: Adenosine Triphosphate; Alanine Transaminase; Androstadienes; Animals; Aspartate Aminotransferases; | 2012 |
Effect of melatonin and n-acetylcysteine on hepatic injury in rat induced by methanol intoxication: a comparative study.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Ani | 2012 |
Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis.
Topics: Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase-1; Kidney; Lipid Peroxides; Liver; Lun | 2012 |
Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Male; Malondialdehyde; Melatonin; Oxidative Stress; R | 2012 |
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.
Topics: Acetamides; Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Anim | 2012 |
Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Disease Models, Animal; Estradiol; Estrogen Repl | 2012 |
Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Body Temperature; Circadian Rhythm; Dise | 2012 |
Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Inhibins; Injections, Intraperitoneal; M | 2012 |
[Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model].
Topics: Acetylserotonin O-Methyltransferase; Animals; Arylalkylamine N-Acetyltransferase; Depression; Diseas | 2012 |
Melatonin decreases levels of S100β and NFΚB, increases levels of synaptophysin in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA3 Region, Hippocampal; Cell Count; Cerebral Cor | 2013 |
Melatonin reduced the elevated matrix metalloproteinase-9 level in a rat photothrombotic stroke model.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug | 2012 |
Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Drug Administration Schedule; Exploratory Behav | 2013 |
Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Immunomodulation; Male; Melatonin; Periodontitis; Rat | 2013 |
[Protective effect of melatonin on myocardial injury in severely- burned rats].
Topics: Animals; Burns; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Male; Malondialdehyde; | 2012 |
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Brain; Disease Models, Animal; Energ | 2013 |
Dietary supplementation of some antioxidants against hypoxia.
Topics: Animals; Antioxidants; Arginine; Chemical and Drug Induced Liver Injury; Cytoprotection; Dietary Sup | 2012 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Role of melatonin and luzindole in rat mammary cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Disease Models, Animal; DNA Fragmentation; Estradiol; Female; | 2012 |
[Protective effect of melatonin in rats with phosgene-induced lung injury].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Male; Malondialdehyde; Melatonin; NF-kappa B; Ni | 2012 |
Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
Topics: Animals; Arginase; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cholestasis, E | 2013 |
Increased melatonin may play dual roles in the striata of a 6-hydroxydopamine model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Data | 2013 |
Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington's disease: protective effect of melatonin.
Topics: Animals; Behavior, Animal; Catalase; Disease Models, Animal; Huntington Disease; Male; Melatonin; Mo | 2013 |
Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome.
Topics: Administration, Oral; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Anima | 2013 |
Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.
Topics: Analgesics; Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; GABA-A Receptor Ant | 2012 |
Effects of memantine and melatonin on signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia in mice.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cerebral Infarction; Corpus Striatum; Disease Models | 2013 |
Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; DNA; DNA Damage; DNA | 2002 |
Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemod | 2002 |
Effect of melatonin and nifedipine on some antioxidant enzymes and different energy fuels in the blood and brain of global ischemic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Blood; Brain; Calcium Channel Blockers; Disease Models | 2002 |
Melatonin improves oxidative organ damage in a rat model of thermal injury.
Topics: Animals; Burns; Disease Models, Animal; Female; Free Radical Scavengers; Intestinal Mucosa; Intestin | 2002 |
Oxidative stress induced by phenylketonuria in the rat: Prevention by melatonin, vitamin E, and vitamin C.
Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Brain; Cerebellum; Disease Models, Animal; F | 2002 |
Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin.
Topics: Adenosine Diphosphate; Administration, Oral; Aging, Premature; Animals; Antioxidants; Dinitrophenols | 2002 |
Behavioral effects of chronic melatonin and pregnenolone injections in a myelin mutant rat (taiep).
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Gait; Gait Disorders, Neurologic; Melatonin | 2002 |
Melatonin prevents focal rat cerebellum injury as assessed by induction of heat shock protein (HO-1) following subarachnoid injections of lysed blood.
Topics: Animals; Antioxidants; Brain Chemistry; Cerebellum; Disease Models, Animal; Female; Heme Oxygenase ( | 2002 |
Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Pressure; Body Weight; Disease Models, Animal; Dr | 2003 |
Antioxidants modulate adenosine metabolism in rat mesangial cells cultured under high glucose conditions.
Topics: Adenosine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Captopril; Cell Culture | 2002 |
Effects of melatonin administration to rats with glycerol-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Antioxidants; Cryoprotective Agents; Disease Models, Animal; Drug Admi | 2002 |
Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Electron Spin Resonance Spectr | 2003 |
[Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice].
Topics: Animals; Brain; Disease Models, Animal; Male; Melatonin; Mice; Morphine Dependence; Nitric Oxide; Su | 2002 |
Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
The ameliorating effect of melatonin on protamine sulfate induced bladder injury and its relationship to interstitial cystitis.
Topics: Animals; Cystitis, Interstitial; Disease Models, Animal; Female; Malondialdehyde; Melatonin; Microsc | 2003 |
Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.
Topics: Animals; Antioxidants; Brain; Carbazoles; Carvedilol; Catalase; Disease Models, Animal; Fatigue Synd | 2002 |
Implication for melatonin and its receptor in the spinal deformities of hereditary Lordoscoliotic Rabbits.
Topics: Age Factors; Animals; Disease Models, Animal; Lordosis; Melatonin; Molecular Sequence Data; Rabbits; | 2003 |
Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors.
Topics: Animals; Diethylstilbestrol; Disease Models, Animal; Male; Melatonin; Nuclear Receptor Subfamily 1, | 2003 |
The effects of pineal gland transplantation on the production of spinal deformity and serum melatonin level following pinealectomy in the chicken.
Topics: Animals; Chickens; Disease Models, Animal; Female; Male; Melatonin; Pineal Gland; Spinal Curvatures; | 2003 |
The protective effect of melatonin on adriamycin-induced acute cardiac injury.
Topics: Animals; Antibiotics, Antineoplastic; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; | 2003 |
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Dise | 2003 |
Effect of melatonin in the prevention of post-operative adhesion formation in a rat uterine horn adhesion model.
Topics: Animals; Disease Models, Animal; Female; Free Radical Scavengers; Injections, Intraperitoneal; Melat | 2003 |
Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury.
Topics: Acute Disease; Alprostadil; Animals; Antioxidants; Aryldialkylphosphatase; Biomarkers; Disease Model | 2003 |
Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Count; Circadian Rhythm; Disease Models, | 2003 |
Transgenic TGR(mREN2)27 rats as a model for disturbed circadian organization at the level of the brain, the heart, and the kidneys.
Topics: Aging; Animals; Animals, Genetically Modified; Blood Pressure; Body Temperature; Brain; Circadian Rh | 2003 |
Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study.
Topics: Animals; Antioxidants; Brain; Brain Damage, Chronic; Disease Models, Animal; Female; Gamma Rays; Mal | 2004 |
Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats.
Topics: Animals; Bone Density; Cartilage; Disease Models, Animal; Free Radical Scavengers; Intervertebral Di | 2003 |
Role of antioxidants in chronic fatigue syndrome in mice.
Topics: Animals; Antioxidants; Brain; Carbazoles; Carvedilol; Catalase; Disease Models, Animal; Fatigue Synd | 2002 |
Protective effect of melatonin on experimental spinal cord ischemia.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxidation; | 2003 |
The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Multiple Organ Failure; Rats; Rats, Sprague-Dawley | 2003 |
Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect.
Topics: Animals; Antineoplastic Agents; Antioxidants; Binding Sites; Circadian Rhythm; Disease Models, Anima | 2004 |
Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Cerebellum; Cerebral Cortex; Diabetes Mellitus, Experimen | 2003 |
Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2004 |
Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2004 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
[Effect of melatonin on the expression of nuclear factor-kappa B and airway inflammation in asthmatic rats].
Topics: Animals; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Lung; Male; Mel | 2004 |
Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Dose-Respo | 2004 |
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interac | 2004 |
Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Drug Therapy, Combination; Edema; Evoked Potentials, Motor; | 2004 |
Circadian rhythms in the retina of rats with photoreceptor degeneration.
Topics: Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Disease Models, Animal; Excitatory Amino A | 2004 |
Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Antioxidants; Brain; Cyclooxygenase 2; Disease Models, Animal; Glial Fibrillary Acidic Prot | 2004 |
Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Brain; Choline O-Ace | 2004 |
Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats.
Topics: Alzheimer Disease; Animals; Apoptosis; Choline O-Acetyltransferase; Cognition Disorders; Disease Mod | 2004 |
Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis.
Topics: Animals; Antioxidants; Cell Death; Cholestasis; Disease Models, Animal; Hepatocytes; Jaundice, Obstr | 2004 |
Effects of melatonin on acute necrotizing pancreatitis in rats.
Topics: Animals; Antioxidants; Clinical Enzyme Tests; Data Interpretation, Statistical; Disease Models, Anim | 2004 |
The effects of exposure to intense, 24 h light on the development of scoliosis in young chickens.
Topics: Adolescent; Animals; Chickens; Circadian Rhythm; Disease Models, Animal; Dose-Response Relationship, | 2002 |
Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Huntington Disease; Lipid Peroxidation; Male; | 2004 |
Protective effect of melatonin on experimental otitis media with effusion in guinea pigs.
Topics: Animals; Antioxidants; Disease Models, Animal; Erythrocytes; Guinea Pigs; Histamine; Lipid Peroxidat | 2004 |
The effects of melatonin on focal cerebral ischemia-reperfusion model.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Models, Animal; Infarction, Middle | 2004 |
Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Anti-Anxiety Agents; Avoidance Learning; Chlordiazepoxide; | 2004 |
Melatonin protects against oxidative organ injury in a rat model of sepsis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2005 |
Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury.
Topics: Animals; Blood Coagulation; Burns; Disease Models, Animal; Female; Fibrin Fibrinogen Degradation Pro | 2005 |
Different effects of melatonin on experimental granulomatous inflammation.
Topics: Animals; Disease Models, Animal; Female; Granuloma; Inflammation Mediators; Melatonin; Rats; Rats, W | 2004 |
Melatonin reduces bacterial translocation after intestinal ischemia-reperfusion injury.
Topics: Animals; Bacterial Translocation; Disease Models, Animal; Intestines; Liver; Lung; Lymph Nodes; Male | 2004 |
Anti-inflammatory and opioid-mediated effects of melatonin on experimental peritonitis in chickens.
Topics: Adjuvants, Immunologic; Animals; beta-Endorphin; Cell Proliferation; Chickens; Disease Models, Anima | 2005 |
Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Free Radical Scavengers; G | 2005 |
Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin.
Topics: Animals; Antioxidants; Catalase; Cell Phone; Disease Models, Animal; Fibrosis; Free Radical Scavenge | 2004 |
Comparison of chemopreventive effects of Vitamin E plus selenium versus melatonin in 7,12-dimethylbenz(a)anthracene-induced mouse brain damage.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Brain; Carbonic Anhydrases; Carcinogens; Ca | 2005 |
Comparison of hyaluronate/carboxymethylcellulose membrane and melatonin for prevention of adhesion formation in a rat model.
Topics: Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Female; Free Radical Scavengers; Hya | 2005 |
Effect of melatonin on cerebral vasospasm following experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Basilar Artery; Cell Count; Disease Models, Animal; Endothelial Cells; Female; M | 2005 |
Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Denervation; Disease Models, Animal; Epilepsy, Temporal Lobe; H | 2005 |
Pathological mechanism of idiopathic scoliosis: experimental scoliosis in pinealectomized rats.
Topics: Animals; Disease Models, Animal; Lordosis; Male; Melatonin; Pineal Gland; Posture; Rats; Rats, Sprag | 2005 |
Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Disease Models, Animal; Glutathione; Hippocampus; | 2005 |
Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats.
Topics: Age Factors; Aging; Alcohol-Induced Disorders, Nervous System; Animals; Biomarkers; Cerebral Cortex; | 2005 |
Radioprotective effects of melatonin on radiation-induced cataract.
Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Female; Free Radical Scavengers; Heavy Ions | 2005 |
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model.
Topics: Acetamides; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticost | 2005 |
Surgical pinealectomy accelerates intervertebral disc degeneration process in chicken.
Topics: Animals; Chickens; Denervation; Disease Models, Animal; Disease Progression; Female; Intervertebral | 2006 |
Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Cytokines; Disease Models, Animal; Female; Inte | 2005 |
Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Axons; Cytoprotection; Disease Models, Animal; Dose-Response Rela | 2005 |
Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C.
Topics: Aldehydes; Animals; Animals, Newborn; Ascorbic Acid; Disease Models, Animal; Drug Interactions; Fema | 2006 |
Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antioxidants; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxyproli | 2006 |
Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Intestinal Mucosa; Ma | 2006 |
Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Pro | 2006 |
Evaluation of the relationship between inducible nitric oxide synthase (iNOS) activity and effects of melatonin in experimental osteoporosis in the rat.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Female; Growth Plate; Immunoenzyme Techniq | 2006 |
Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin.
Topics: Alkaloids; Animals; Benzophenanthridines; Disease Models, Animal; Disease Progression; Drug Therapy, | 2006 |
Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety.
Topics: Acetamides; Animals; Anti-Anxiety Agents; Arousal; Brain; Buspirone; Chronotherapy; Conditioning, Cl | 2006 |
Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitis.
Topics: Animals; Antioxidants; Aprotinin; Choroid; Disease Models, Animal; Free Radical Scavengers; Guinea P | 2006 |
The effect of exogenous melatonin administration on trabecular width, ligament thickness and TGF-beta(1) expression in degenerated intervertebral disk tissue in the rat.
Topics: Animals; Antioxidants; Disease Models, Animal; Gene Expression; Immunohistochemistry; Intervertebral | 2006 |
Does anti-oxidant prophylaxis with melatonin prevent adverse outcomes related to increased oxidative stress caused by laparoscopy in experimental rat model?
Topics: Animals; Antioxidants; Disease Models, Animal; Intestine, Small; Kidney; Laparoscopy; Liver; Male; M | 2006 |
The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats.
Topics: Animals; Disease Models, Animal; Female; Glutathione; Malondialdehyde; Melatonin; Rats; Rats, Wistar | 2006 |
Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cicatrix; Disease Models, Animal; Drug Therapy, Combina | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
Anticonvulsant effects of melatonin on penicillin-induced epileptiform activity in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Resp | 2006 |
Melatonin attenuates renal ischemia-reperfusion injury in nitric oxide synthase inhibited rats.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Kidney; Male; Malondialdehyde; Melatonin; NG-Nit | 2006 |
Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats.
Topics: Animals; Aspirin; Bile Ducts; Catalase; Cholestasis; Disease Models, Animal; Glutathione Peroxidase; | 2006 |
Influence of melatonin and acetylsalicylic acid on lipid peroxidation and antioxidant enzyme activities in gastric mucosa.
Topics: Animals; Aspirin; Bile Ducts; Disease Models, Animal; Gastric Mucosa; Lipid Peroxidation; Melatonin; | 2006 |
Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice.
Topics: Animals; Antioxidants; Cadmium; Catalase; Curcumin; Disease Models, Animal; Drug Interactions; Drug | 2006 |
[Neuroprotective effects of melatonin against hypoxic-ischemic brain damage in neonatal rats].
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Brain; Disease Models, Animal; Female; Hypoxia-I | 2006 |
Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice.
Topics: Animals; Brain; Brain Edema; Cerebral Infarction; Cerebrovascular Circulation; Cyclooxygenase 1; Dis | 2006 |
Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Axotomy; bcl-2-Associated X Protein; | 2006 |
Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens.
Topics: Animals; Cell Fractionation; Cell Membrane; Chickens; Circadian Rhythm; Disease Models, Animal; Iodi | 2006 |
Possible beneficial effects of melatonin supplementation on arsenic-induced oxidative stress in Wistar rats.
Topics: Animals; Antioxidants; Arsenic Poisoning; Arsenites; Carcinogens; Catalase; Disease Models, Animal; | 2006 |
Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
Topics: Animals; Antioxidants; Collagenases; Disease Models, Animal; DNA Primers; Enzyme Precursors; Gene Ex | 2006 |
Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Disease Models, Animal | 2006 |
Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum.
Topics: Animals; Aquaporin 4; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain Edema; Capillary Permeabili | 2006 |
Antiinflammatory but no neuroprotective effects of melatonin under clinical treatment conditions in rabbit models of bacterial meningitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Count; Dinoprostone; Disease Models | 2006 |
Protective effect of melatonin against chlorpromazine-induced liver disease in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease Models, Anima | 2006 |
Melatonin modulates signal transduction pathways and apoptosis in experimental colitis.
Topics: Animals; Apoptosis; Colitis; Cytokines; Dinitrofluorobenzene; Disease Models, Animal; JNK Mitogen-Ac | 2006 |
Use of melatonin to prevent selenite-induced cataract formation in rat eyes.
Topics: Animals; Animals, Newborn; Antioxidants; Catalase; Cataract; Disease Models, Animal; Lens, Crystalli | 2006 |
Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment.
Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Cell Membrane; Disease Models, Animal; Hypox | 2007 |
The effect of melatonin on ductus epididymis. Unilateral testicular torsion in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epididymis; Immunohistochemistry; | 2007 |
The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study.
Topics: Analysis of Variance; Animals; Antioxidants; Disease Models, Animal; Glutathione Peroxidase; Male; M | 2007 |
Effect of melatonin on healing of colonic anastomosis in a rat model of peritonitis.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Colon; Disease Models, Animal; Glutathione; Interleuki | 2007 |
[The cytokine profile during experimental esophagitis and modification of cytoprotective mechanisms].
Topics: Animals; Cyclooxygenase Inhibitors; Cytokines; Cytoprotection; Disease Models, Animal; Esophagitis; | 2006 |
Does pinealectomy affect the recovery rate after spinal cord injury?
Topics: Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Gene Expression Regulation; Glutath | 2007 |
Neuroprotective effects of melatonin upon the offspring cerebellar cortex in the rat model of BCNU-induced cortical dysplasia.
Topics: Animals; Animals, Newborn; Brain Diseases; Bromodeoxyuridine; Carmustine; Cerebellar Cortex; Disease | 2007 |
Regression of endometrial explants in a rat model of endometriosis treated with melatonin.
Topics: Abdominal Wall; Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Cyclooxygenase 2; Disease | 2008 |
Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery.
Topics: Animals; Chronic Disease; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Melatonin; | 2008 |
Effects of melatonin on gallbladder neuromuscular function in acute cholecystitis.
Topics: Animals; Antioxidants; Cholecystitis, Acute; Disease Models, Animal; Gallbladder; Guinea Pigs; Male; | 2007 |
Protective effects of melatonin and N-acetylcysteine on hepatic injury in a rat cardiopulmonary bypass model.
Topics: Acetylcysteine; Animals; Apoptosis; Cardiopulmonary Bypass; Disease Models, Animal; Free Radical Sca | 2007 |
Effects of combination of melatonin and dexamethasone on secondary injury in an experimental mice model of spinal cord trauma.
Topics: Animals; Dexamethasone; Disease Models, Animal; Fas Ligand Protein; Immunohistochemistry; Melatonin; | 2007 |
Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Indocyanine Green; Liver; Liver Circulation; Male; Melatonin; NADP; | 2008 |
Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats.
Topics: Animals; Antioxidants; Bile Ducts, Extrahepatic; Brain; Catalase; Disease Models, Animal; Free Radic | 2007 |
Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats.
Topics: Analysis of Variance; Animals; Body Weight; Cholesterol; Disease Models, Animal; Eating; Estradiol C | 2007 |
Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard.
Topics: Animals; Antioxidants; Biomarkers; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Re | 2007 |
Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Cell Line; Disease Models, Animal; Male; Melatonin; Neurons; Oxidopamine; | 2007 |
Beneficial properties of melatonin in an experimental model of pancreatic cancer.
Topics: Animals; Antioxidants; Body Weight; Cricetinae; Disease Models, Animal; Lipid Peroxides; Male; Melat | 2007 |
Melatonin ameliorates blood-brain barrier permeability, glutathione, and nitric oxide levels in the choroid plexus of the infantile rats with kaolin-induced hydrocephalus.
Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Choroid Plexus; Disease Models, Animal; Endothelial | 2007 |
Melatonin prevents learning disorders in brain-lesioned newborn mice.
Topics: Animals; Animals, Newborn; Central Nervous System Depressants; Conditioning, Psychological; Disease | 2007 |
[The effect of melatonin on the regulation of collagen accumulation and matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 mRNA and protein in a murine model of chronic asthma].
Topics: Animals; Asthma; Collagen; Dexamethasone; Disease Models, Animal; Male; Matrix Metalloproteinase 9; | 2007 |
Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model.
Topics: Animals; Apoptosis; Carbon Dioxide; Cardiopulmonary Bypass; Disease Models, Animal; Dose-Response Re | 2008 |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
Topics: Actins; Animals; Blood Pressure; Cell Movement; Collagen Type IV; Creatinine; Disease Models, Animal | 2008 |
Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats.
Topics: Animals; Antioxidants; Coloring Agents; Disease Models, Animal; Indocyanine Green; Liver; Liver Func | 2008 |
[Protective effect of melatonin against renal dysfunction following severe burn in rats].
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Burns; Creatinine; Disease Models, Animal; Glutathione; | 2007 |
Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis.
Topics: Animals; Antioxidants; Disease Models, Animal; Dizocilpine Maleate; Male; Malondialdehyde; Melatonin | 2008 |
Melatonin, shedding new light on darkness.
Topics: Animals; Antioxidants; Coloring Agents; Disease Models, Animal; Humans; Indocyanine Green; Liver; Me | 2008 |
The role of melatonin in the pathogenesis of hypertension in rats with metabolic syndrome.
Topics: Animals; Blood Pressure; Body Weight; Dietary Sucrose; Dietary Supplements; Disease Models, Animal; | 2008 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8.
Topics: Aging; Animals; Antioxidants; Disease Models, Animal; Heredodegenerative Disorders, Nervous System; | 2008 |
Effects of melatonin on ischemic spinal cord injury caused by aortic cross clamping in rabbits.
Topics: Animals; Antioxidants; Aorta, Abdominal; Constriction; Disease Models, Animal; Glutathione; Male; Ma | 2008 |
Chronic and acute melatonin effects in gerbil global forebrain ischemia: long-term neural and behavioral outcome.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Count; Cell Differentiation; Disease Models, Animal; | 2008 |
Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hypoxia-Ischemia, Brain; Melatonin; Rats; | 2008 |
Melatonin decreases mortality following severe subarachnoid hemorrhage.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Male; Melatonin; Neuroprotective Agents; Oxida | 2008 |
Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.
Topics: Animals; Cell Count; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Down-Regul | 2008 |
Exacerbated mechanical allodynia in rats with depression-like behavior.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu | 2008 |
Specific N-terminal mutations in the human androgen receptor induce cytotoxicity.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Behavioral Symptoms; Butyrates; Chloroc | 2009 |
Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Ligation; Male; Melatonin; Multiple Organ Fail | 2008 |
Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis.
Topics: Adolescent; Adult; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; | 2008 |
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Diseas | 2008 |
The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Cross- | 2008 |
Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2008 |
Melatonin attenuates hypoxia-induced ultrastructural changes and increased vascular permeability in the developing hippocampus.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain Edema; Dendrites; Di | 2008 |
Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.
Topics: Adenosine Triphosphate; Aging; Aging, Premature; Animals; Disease Models, Animal; Drug Administratio | 2008 |
Influence of protein--calorie malnutrition on the circadian rhythm of pineal melatonin in the rat.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Male; Melatonin; Pineal Gland; Protein-Energy Mal | 1981 |
Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Hydrocortisone; Hypocalcemia; Inf | 1981 |
Pineal gland in autoimmunity: melatonin-dependent exaggeration of collagen-induced arthritis in mice.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Bromocriptine; Collagen; Darkness | 1994 |
Successful use of S20098 and melatonin in an animal model of delayed sleep-phase syndrome (DSPS).
Topics: Acetamides; Animals; Circadian Rhythm; Disease Models, Animal; Hypnotics and Sedatives; Male; Melato | 1993 |
Pinealectomy ameliorates collagen II-induced arthritis in mice.
Topics: Animals; Arthritis, Experimental; Collagen; Disease Models, Animal; H-2 Antigens; Haplotypes; Melato | 1993 |
Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Chromatography, High Pressure | 1997 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 1997 |
Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: replication study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Electromagnetic Fiel | 1998 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; D | 1998 |
Protective effect of melatonin in a model of traumatic brain injury in mice.
Topics: Animals; Antioxidants; Body Temperature; Brain Injuries; Cyclic N-Oxides; Disease Models, Animal; Do | 1998 |
Anticonvulsant effects of melatonin in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Dose-Response Relation | 1998 |
The production of scoliosis after pinealectomy in young chickens, rats, and hamsters.
Topics: Animals; Animals, Newborn; Chickens; Cricetinae; Disease Models, Animal; Melatonin; Mesocricetus; Pi | 1999 |
Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Biopterins; Breast Neoplasms; Catecholami | 1999 |
The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken.
Topics: Animals; Bone and Bones; Chickens; Disease Models, Animal; Melatonin; Pineal Gland; Scoliosis | 1999 |
A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Availability; Body Weight; Circadi | 1999 |
Pathogenesis of idiopathic scoliosis. Experimental study in rats.
Topics: Animals; Disease Models, Animal; Humans; Locomotion; Male; Melatonin; Pineal Gland; Posture; Radiogr | 1999 |
Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan.
Topics: Animals; Antioxidants; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Kidne | 1999 |
Melatonin as a free radical scavenger in experimental head trauma.
Topics: Animals; Brain Injuries; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Malondialde | 1999 |
Serial transplants of DMBA-induced mammary tumors in fischer rats as model system for human breast cancer: V. Myoepithelial-mesenchymal conversion during passaging as possible cause for modulation of pineal-tumor interaction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Adenocarcinoma; Animals; Disease Models, Animal; Epitheliu | 2000 |
[Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats].
Topics: Animals; Antioxidants; Body Temperature; Circadian Rhythm; Disease Models, Animal; Injections, Intra | 2000 |
Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation.
Topics: Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Antioxidants; Benzodiazepinones; Bic | 2000 |
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity.
Topics: Adenosine Triphosphatases; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Electron | 2001 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease | 2001 |
Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks.
Topics: Aging; Alzheimer Disease; Amnesia; Animals; Antioxidants; Avoidance Learning; Data Interpretation, S | 2001 |
Assessment of the relationship between dynamic pattern of nighttime levels of melatonin and chosen biochemical markers of bone metabolism in a rat model of postmenopausal osteoporosis.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone and Bones; Calcium; Circadian Rhythm; Collagen; Coll | 2001 |
Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation.
Topics: Acute Disease; Animals; Carrageenan; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme A | 2001 |
Melatonin protects against renal oxidative stress after obstructive jaundice in rats.
Topics: Animals; Antioxidants; Cholestasis; Disease Models, Animal; Kidney Function Tests; Male; Melatonin; | 2001 |
The lack of vasoconstrictor effect of the pineal hormone melatonin in an animal model predictive of antimigraine activity.
Topics: Animals; Antioxidants; Blood Pressure; Carotid Arteries; Disease Models, Animal; Dose-Response Relat | 2001 |
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge.
Topics: Animals; Animals, Newborn; Antioxidants; Cell Death; Cerebral Palsy; Cystine; Denervation; Disease M | 2002 |
Influence of some substances on bacterial translocation in the rat.
Topics: Adjuvants, Immunologic; Animals; Anti-Ulcer Agents; Bacterial Translocation; Blood; Disease Models, | 2002 |
Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin.
Topics: Administration, Oral; Alitretinoin; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Dis | 2002 |
Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice.
Topics: Animals; Cell Survival; Disease Models, Animal; Male; Melatonin; Mice; Mice, Inbred C57BL; Optic Ner | 2002 |
Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Hemodynamics; Image Processing, | 2002 |
Protective effect of melatonin in a chronic experimental model of Parkinson's disease.
Topics: Animals; Axons; Cell Death; Chronic Disease; Disease Models, Animal; DNA Fragmentation; Dose-Respons | 2002 |
Effects of melatonin on the photosensitive epilepsy of the baboon, Papio papio.
Topics: Animals; Disease Models, Animal; Electroencephalography; Evoked Potentials; Female; Haplorhini; Ligh | 1976 |
Diurnal variations in the electroretinographic c-wave and retinal melatonin content in rats with inherited retinal dystrophy.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electroretinography; Melatonin; Phagocytosis; Pig | 1992 |
Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo.
Topics: Animals; Disease Models, Animal; Estradiol; Female; Mammary Neoplasms, Experimental; Melatonin; Meth | 1991 |
Melatonin modulates apomorphine-induced rotational behaviour.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Hun | 1991 |
Effects of melatonin and hypothyroidism on somatomedin levels of female Syrian hamsters.
Topics: Animals; Cricetinae; Darkness; Disease Models, Animal; Drug Combinations; Female; Growth Hormone; Hy | 1989 |
[The early diagnosis, evaluation of treatment results and modelling of certain aspects of the pathogenesis of retinal dystrophy].
Topics: Adult; Aged; Animals; Conjunctiva; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclin | 1989 |
The pathophysiology of enlarged ventricles in normal pressure communicating hydrocephalus and schizophrenia: a possible therapeutic role for melatonin.
Topics: Animals; Cerebral Ventricles; Disease Models, Animal; Humans; Hydrocephalus; Hydrocephalus, Normal P | 1987 |
Inhibition of compensatory ovarian hypertrophy in the mouse and vole: a comparison of Altschule's pineal extract, pineal indoles, vasopressin, and oxytocin.
Topics: Animals; Castration; Disease Models, Animal; Drug Antagonism; Female; Follicle Stimulating Hormone; | 1972 |
Effects of melatonin and serotonin on the release of FSH and prolactin.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Chiari-Frommel Syndrome; Depression, Chemical; D | 1971 |