melatonin has been researched along with Diabetic Nephropathies in 18 studies
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy." | 7.96 | Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020) |
| "Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy." | 3.96 | Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020) |
| "Melatonin is a powerful antioxidant that has a wide range of biological activities." | 2.82 | Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis. ( Cai, Y; Jiang, Y; Liu, WJ; Liu, Y; Luo, Q; Tian, L; Zhao, Q, 2022) |
| "Melatonin is an endogenous hormone related to the regulation of biorhythm." | 1.91 | Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. ( Fang, X; Gao, F; Huang, D; Huang, W; Liu, F; Sun, Q; Sun, R; Wang, B; Zhang, Y; Zhao, Y, 2023) |
| "Melatonin is a physiological hormone mainly secreted by the pineal gland which has been proved to be related to diabetes." | 1.91 | Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress. ( Deng, X; Guo, C; He, J; Wang, D; Yuan, G, 2023) |
| "Melatonin treatment reduced expression and activity of ROCK1 and ROCK2, which suppressed TGF-β2-induced hyperpermeability of GEnCs and EndMT of GEnCs." | 1.48 | Melatonin Attenuates Endothelial-to-Mesenchymal Transition of Glomerular Endothelial Cells via Regulating miR-497/ROCK in Diabetic Nephropathy. ( Gao, S; Liu, F; Xu, R; Yin, J; Zhang, S, 2018) |
| "Melatonin has been considered a robust anti‑oxidant, and is able to attenuate DN in several animal models." | 1.43 | Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model. ( Ji, ZZ; Xu, YC, 2016) |
| "Melatonin was more efficient in reducing MDA levels than other antioxidants (p < 0." | 1.42 | Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. ( Ates, B; Elbe, H; Esrefoglu, M; Taskapan, C; Vardi, N; Yologlu, S, 2015) |
| "Melatonin treatment did not improve these hemorheological abnormalities." | 1.34 | Short-term melatonin treatment improved diabetic nephropathy but did not affect hemorheological changes in diabetic rats. ( Bediz, CS; Ergonen, AT; Gumustekin, M; Guneli, E; Ozdemir, MH; Tekmen, I; Topcu, A; Tugyan, K; Uysal, N, 2007) |
| " Chronic administration of melatonin (n = 6) and taurine (n = 6) prevented increases in glomerular TGF-beta1 and fibronectin mRNAs and proteinuria without having effect on blood glucose." | 1.30 | Melatonin and taurine reduce early glomerulopathy in diabetic rats. ( Ha, H; Kim, KH; Yu, MR, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 9 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Talari, HR | 1 |
| Tabatabaei, SMH | 1 |
| Soleimani, A | 2 |
| Sayyah, M | 1 |
| Bozorgi, M | 1 |
| Luo, Q | 1 |
| Cai, Y | 1 |
| Zhao, Q | 1 |
| Jiang, Y | 1 |
| Tian, L | 1 |
| Liu, Y | 2 |
| Liu, WJ | 1 |
| Tang, H | 1 |
| Yang, M | 1 |
| Zhu, X | 1 |
| Liu, S | 1 |
| Liu, H | 1 |
| Sun, L | 1 |
| Song, P | 1 |
| Siddhi, J | 1 |
| Sherkhane, B | 1 |
| Kalavala, AK | 1 |
| Arruri, V | 1 |
| Velayutham, R | 1 |
| Kumar, A | 1 |
| Mahmoud, NM | 1 |
| Elshazly, SM | 1 |
| Hassan, AA | 1 |
| Soliman, E | 1 |
| Fang, X | 1 |
| Huang, W | 1 |
| Sun, Q | 1 |
| Zhao, Y | 1 |
| Sun, R | 1 |
| Liu, F | 2 |
| Huang, D | 1 |
| Zhang, Y | 1 |
| Gao, F | 1 |
| Wang, B | 1 |
| Esmaie, EM | 1 |
| Abo-Youssef, AM | 1 |
| Tohamy, MA | 1 |
| Fan, Z | 1 |
| Qi, X | 1 |
| Yang, W | 1 |
| Xia, L | 1 |
| Wu, Y | 1 |
| Satari, M | 1 |
| Bahmani, F | 1 |
| Reiner, Z | 1 |
| Aghadavod, E | 1 |
| Kheiripour, N | 1 |
| Asemi, Z | 1 |
| Guo, C | 1 |
| He, J | 1 |
| Deng, X | 1 |
| Wang, D | 1 |
| Yuan, G | 1 |
| Rashed, LA | 1 |
| Elattar, S | 1 |
| Eltablawy, N | 1 |
| Ashour, H | 1 |
| Mahmoud, LM | 1 |
| El-Esawy, Y | 1 |
| Zhang, S | 1 |
| Xu, R | 1 |
| Gao, S | 1 |
| Yin, J | 1 |
| Elbe, H | 1 |
| Vardi, N | 1 |
| Esrefoglu, M | 1 |
| Ates, B | 1 |
| Yologlu, S | 1 |
| Taskapan, C | 1 |
| Winiarska, K | 1 |
| Dzik, JM | 1 |
| Labudda, M | 1 |
| Focht, D | 1 |
| Sierakowski, B | 1 |
| Owczarek, A | 1 |
| Komorowski, L | 1 |
| Bielecki, W | 1 |
| Onk, D | 1 |
| Onk, OA | 1 |
| Turkmen, K | 1 |
| Erol, HS | 1 |
| Ayazoglu, TA | 1 |
| Keles, ON | 1 |
| Halici, M | 1 |
| Topal, E | 1 |
| Ji, ZZ | 1 |
| Xu, YC | 1 |
| Gumustekin, M | 1 |
| Tekmen, I | 1 |
| Guneli, E | 1 |
| Tugyan, K | 1 |
| Topcu, A | 1 |
| Ergonen, AT | 1 |
| Ozdemir, MH | 1 |
| Uysal, N | 1 |
| Bediz, CS | 1 |
| Ha, H | 1 |
| Yu, MR | 1 |
| Kim, KH | 1 |
1 review available for melatonin and Diabetic Nephropathies
| Article | Year |
|---|---|
Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Melatonin; M | 2022 |
2 trials available for melatonin and Diabetic Nephropathies
| Article | Year |
|---|---|
The effects of melatonin administration on carotid intima-media thickness and pulse wave velocity in diabetic nephropathy: A randomized, double-blind, placebo-controlled trial.
Topics: Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Mellitus; Diabetic Nephropathies; Humans; | 2022 |
Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus; Diabet | 2021 |
15 other studies available for melatonin and Diabetic Nephropathies
| Article | Year |
|---|---|
Melatonin alleviates renal injury by activating mitophagy in diabetic nephropathy.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus; Diabetic Nephropathies; Inflammation; Kid | 2022 |
Melatonin prevents diabetes-induced nephropathy by modulating the AMPK/SIRT1 axis: Focus on autophagy and mitochondrial dysfunction.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2022 |
Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Experimental; D | 2023 |
Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation.
Topics: Animals; Apoptosis; Cellular Senescence; Diabetes Mellitus; Diabetic Nephropathies; Humans; Melatoni | 2023 |
Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glyco | 2019 |
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Topics: Animals; Central Nervous System Depressants; Diabetes Mellitus, Experimental; Diabetic Nephropathies | 2020 |
Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress.
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus; Diabetic Nephropathies; Humans; Melatonin; Oxidative | 2023 |
Mesenchymal stem cells pretreated with melatonin ameliorate kidney functions in a rat model of diabetic nephropathy.
Topics: Allografts; Animals; Diabetic Nephropathies; Disease Models, Animal; Kidney; Male; Melatonin; Mesenc | 2018 |
Melatonin Attenuates Endothelial-to-Mesenchymal Transition of Glomerular Endothelial Cells via Regulating miR-497/ROCK in Diabetic Nephropathy.
Topics: Animals; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetic Nephropathi | 2018 |
Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats.
Topics: Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Catalase; Creatinine; Diabetes Mellitus, | 2015 |
Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase.
Topics: Animals; Cell Membrane; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Reg | 2016 |
Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Interl | 2016 |
Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model.
Topics: Angiotensin II; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Diabetic N | 2016 |
Short-term melatonin treatment improved diabetic nephropathy but did not affect hemorheological changes in diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Blood Vessels; Diabetes Mellitus, Experimental; Dia | 2007 |
Melatonin and taurine reduce early glomerulopathy in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diures | 1999 |