melatonin has been researched along with Diabetes Mellitus in 59 studies
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to carry out a broad narrative review of the metabolic profile and associations between melatonin, diabetes and obesity." | 9.12 | Melatonin and its Relationships with Diabetes and Obesity: A Literature Review. ( de Sá, LBPC; Filho, DR; Ramirez, AVG, 2021) |
| " Melatonin is a strong anti-inflammatory hormone, mediating the cytoprotective effect of a variety of retinal cells against hyperglycemia." | 7.96 | Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. ( Chen, L; Liu, W; Liu, X; Shi, Q; Song, E; Sun, Y; Tu, Y; Wang, K; Wang, X; Wang, Z; Zhao, Q; Zhu, M, 2020) |
| "To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)." | 7.91 | Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019) |
| "Resveratrol/melatonin combination effectively normalizes anthropometrical, biochemical, and histopathological parameters in ovariectomized rats with fructose diet-induced obesity and associated metabolic alterations." | 7.80 | Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats. ( Giri, PR; Majumdar, AS; Pai, SA, 2014) |
| "The study objective was to investigate the effects of melatonin on obesity and obesity-associated systolic hypertension and dyslipidemia in young male Zucker diabetic fatty (ZDF) rats, an experimental model of the metabolic syndrome." | 7.77 | Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. ( Abuhamadah, S; Agil, A; El-Mir, MY; Navarro-Alarcón, M; Ruiz, R; Vázquez, GF, 2011) |
| "Melatonin is a multifunctional signaling hormone synthesized and secreted primarily by the pineal gland." | 6.66 | Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19. ( El-Missiry, MA; El-Missiry, ZMA; Othman, AI, 2020) |
| "Melatonin (MEL) is a pleiotropic neurohormone of increasing interest as a neuroprotective agent in ocular diseases." | 5.72 | Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model. ( Bonaccorso, A; Bucolo, C; Caggia, C; Carbone, C; Daniela Anfuso, C; Giurdanella, G; Lupo, G; Musumeci, T; Pignatello, R; Randazzo, C; Rizzo, M; Romano, GL; Romeo, A; Ruozi, B; Russo, N; Thomas Duskey, J; Tosi, G, 2022) |
| "Melatonin can reduce damage to male rodents' gonadal tissue and improve sperm count, motility, and morphology in metabolic diseases." | 5.41 | Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models. ( Ala, M; Azarpira, N; Dehdari Ebrahimi, N; Ebrahimi, F; Pakbaz, S; Sadeghi, A, 2023) |
| "This study aimed to carry out a broad narrative review of the metabolic profile and associations between melatonin, diabetes and obesity." | 5.12 | Melatonin and its Relationships with Diabetes and Obesity: A Literature Review. ( de Sá, LBPC; Filho, DR; Ramirez, AVG, 2021) |
| " We included randomized clinical trials investigating melatonin supplementation's effects, compared to placebo, on fasting blood glucose, insulin resistance, and glycated hemoglobin." | 5.12 | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials. ( Delpino, FM; Figueiredo, LM; Nunes, BP, 2021) |
| "This review focuses on seven aspects of physiology and pathophysiology of the exocrine pancreas that have been intensively discussed and studied within the past few years: (1) the role of neurohormonal mechanisms like melatonin, leptin, or ghrelin in the stimulation of pancreatic enzyme secretion; (2) the initiation processes of acute pancreatitis, like fusion of zymogen granules with lysosomes leading to intracellular activation of trypsinogen by the lysosomal enzyme cathepsin B, or autoactivation of trypsinogen; (3) the role of genes in the pathogenesis of acute pancreatitis; (4) the role of alcohol and constituents of alcoholic beverages in the pathogenesis of acute pancreatitis; (5) the role of pancreatic hypertension, neuropathy, and central mechanisms for the pathogenesis of pain in chronic pancreatitis; (6) the relation between exocrine pancreatic function and diabetes mellitus; and (7) pathophysiology, diagnosis and treatment of pancreatic steatorrhea." | 4.90 | An update on pancreatic pathophysiology (do we have to rewrite pancreatic pathophysiology?). ( Hammer, HF, 2014) |
| " Melatonin is a strong anti-inflammatory hormone, mediating the cytoprotective effect of a variety of retinal cells against hyperglycemia." | 3.96 | Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. ( Chen, L; Liu, W; Liu, X; Shi, Q; Song, E; Sun, Y; Tu, Y; Wang, K; Wang, X; Wang, Z; Zhao, Q; Zhu, M, 2020) |
| "To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)." | 3.91 | Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019) |
| "Resveratrol/melatonin combination effectively normalizes anthropometrical, biochemical, and histopathological parameters in ovariectomized rats with fructose diet-induced obesity and associated metabolic alterations." | 3.80 | Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats. ( Giri, PR; Majumdar, AS; Pai, SA, 2014) |
| "We aimed to evaluate the effects of two immune regulatory factors, interleukin-4 (IL-4) and melatonin, on several inflammatory mediators that are involved in inflammation and angiogenesis in diabetic retinopathy (DR), in high glucose or interleukin-1β (IL-1β) induced primary human retinal endothelial cells (RECs) and human retinal pigment epithelial (RPE) cells." | 3.80 | Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells. ( Hu, A; Hu, X; Luo, Y; Sun, W; Tang, S; Xie, M, 2014) |
| "Several pathological conditions, including hypertension, atherosclerosis, diabetes, ischemia/reperfusion injury and nicotine-induced vasculopathy, are associated with vascular endothelial dysfunction characterized by altered secretory output of endothelial cells." | 3.79 | Vascular endothelial cells and dysfunctions: role of melatonin. ( Castrezzati, S; Favero, G; Foglio, E; Lonati, C; Rezzani, R; Rodella, LF; Rossini, C, 2013) |
| "The study objective was to investigate the effects of melatonin on obesity and obesity-associated systolic hypertension and dyslipidemia in young male Zucker diabetic fatty (ZDF) rats, an experimental model of the metabolic syndrome." | 3.77 | Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. ( Abuhamadah, S; Agil, A; El-Mir, MY; Navarro-Alarcón, M; Ruiz, R; Vázquez, GF, 2011) |
| "Treatment with melatonin improves oxidative stress, blocks apoptosis induced by endoplasmic reticulum stress and caspase activation, reduces pro-inflammation cytokines, and enhances steroidogenesis." | 2.82 | A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies. ( Abdollahi, M; Armandeh, M; Ataei, M; Bameri, B; Foroumadi, R; Haghi-Aminjan, H; Hassani, S; Samadi, M; Shayesteh, MRH, 2022) |
| "Melatonin is a multifunctional signaling hormone synthesized and secreted primarily by the pineal gland." | 2.66 | Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19. ( El-Missiry, MA; El-Missiry, ZMA; Othman, AI, 2020) |
| "Melatonin is a hormone secreted by the pineal gland under the control of the circadian rhythm, and is released in the dark and suppressed during the day." | 2.61 | A new prospective on the role of melatonin in diabetes and its complications. ( Chye, SM; Koh, RY; Mok, JX; Ng, KY; Ooi, JH, 2019) |
| "Melatonin was reported to prevent mitochondrial dysfunction from oxidative damage by preserving cardiolipin integrity, and this may explain, at least in part, the beneficial effect of this compound in mitochondrial physiopathology." | 2.52 | Protective role of melatonin in mitochondrial dysfunction and related disorders. ( Paradies, G; Paradies, V; Petrosillo, G; Ruggiero, FM, 2015) |
| " The recognition of the periodicity of biological processes makes the optimal dosing of certain drugs feasible." | 2.48 | [Physiological and pathophysiological role of the circadian clock system]. ( Halmos, T; Suba, I, 2012) |
| "Melatonin is an endogenous hormone related to the regulation of biorhythm." | 1.91 | Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. ( Fang, X; Gao, F; Huang, D; Huang, W; Liu, F; Sun, Q; Sun, R; Wang, B; Zhang, Y; Zhao, Y, 2023) |
| "Melatonin is a physiological hormone mainly secreted by the pineal gland which has been proved to be related to diabetes." | 1.91 | Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress. ( Deng, X; Guo, C; He, J; Wang, D; Yuan, G, 2023) |
| "Melatonin (MEL) is a pleiotropic neurohormone of increasing interest as a neuroprotective agent in ocular diseases." | 1.72 | Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model. ( Bonaccorso, A; Bucolo, C; Caggia, C; Carbone, C; Daniela Anfuso, C; Giurdanella, G; Lupo, G; Musumeci, T; Pignatello, R; Randazzo, C; Rizzo, M; Romano, GL; Romeo, A; Ruozi, B; Russo, N; Thomas Duskey, J; Tosi, G, 2022) |
| "Melatonin secretion was significantly and inversely associated with diabetes in males but not in females." | 1.48 | Gender differences in the association between melatonin secretion and diabetes in elderly: The HEIJO-KYO cohort. ( Iwamoto, J; Kurumatani, N; Obayashi, K; Saeki, K; Yamagami, Y, 2018) |
| "Melatonin is a potent deprogrammer of neonatal corticosterone programming effects and the adult thrifty phenotype alteration to a diabetogenic challenge." | 1.38 | Neonatal corticosterone programs for thrifty phenotype adult diabetic manifestations and oxidative stress: countering effect of melatonin as a deprogrammer. ( Baxi, DB; Ramachandran, AV; Singh, PK; Vachhrajani, KD, 2012) |
| "Melatonin-induced increase in glucose and lactate synthesis was accompanied by an enhancement of alanine and glycerol consumption." | 1.33 | Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules. ( Bryla, J; Derlacz, RA; Jagielski, AK; Napierala, M; Poplawski, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.69) | 18.7374 |
| 1990's | 1 (1.69) | 18.2507 |
| 2000's | 5 (8.47) | 29.6817 |
| 2010's | 27 (45.76) | 24.3611 |
| 2020's | 25 (42.37) | 2.80 |
| Authors | Studies |
|---|---|
| Tysoe, O | 1 |
| Oliveira-Abreu, K | 1 |
| Cipolla-Neto, J | 1 |
| Leal-Cardoso, JH | 1 |
| Talari, HR | 1 |
| Tabatabaei, SMH | 1 |
| Soleimani, A | 3 |
| Sayyah, M | 1 |
| Bozorgi, M | 1 |
| Patel, R | 1 |
| Parmar, N | 1 |
| Rathwa, N | 1 |
| Palit, SP | 1 |
| Li, Y | 1 |
| Garcia-Ocaña, A | 1 |
| Begum, R | 1 |
| Tang, L | 1 |
| Zhang, C | 1 |
| Lu, L | 1 |
| Tian, H | 1 |
| Liu, K | 1 |
| Luo, D | 1 |
| Qiu, Q | 1 |
| Xu, GT | 1 |
| Zhang, J | 1 |
| Tang, H | 1 |
| Yang, M | 1 |
| Liu, Y | 1 |
| Zhu, X | 1 |
| Liu, S | 1 |
| Liu, H | 1 |
| Sun, L | 1 |
| Song, P | 1 |
| Bargues-Navarro, G | 1 |
| Ibáñez-Del Valle, V | 1 |
| El Mlili, N | 1 |
| Cauli, O | 1 |
| Ocak, Ö | 1 |
| Silan, F | 1 |
| Şahin, EM | 1 |
| Romeo, A | 1 |
| Bonaccorso, A | 1 |
| Carbone, C | 1 |
| Lupo, G | 1 |
| Daniela Anfuso, C | 1 |
| Giurdanella, G | 1 |
| Caggia, C | 1 |
| Randazzo, C | 1 |
| Russo, N | 1 |
| Romano, GL | 1 |
| Bucolo, C | 1 |
| Rizzo, M | 1 |
| Tosi, G | 1 |
| Thomas Duskey, J | 1 |
| Ruozi, B | 1 |
| Pignatello, R | 1 |
| Musumeci, T | 1 |
| Armandeh, M | 1 |
| Bameri, B | 1 |
| Haghi-Aminjan, H | 1 |
| Foroumadi, R | 1 |
| Ataei, M | 1 |
| Hassani, S | 1 |
| Samadi, M | 1 |
| Shayesteh, MRH | 1 |
| Abdollahi, M | 1 |
| Zeng, Y | 1 |
| Zhang, Z | 1 |
| Liang, S | 1 |
| Chang, X | 1 |
| Qin, R | 1 |
| Chen, H | 1 |
| Guo, L | 1 |
| Dehdari Ebrahimi, N | 1 |
| Sadeghi, A | 1 |
| Ala, M | 1 |
| Ebrahimi, F | 1 |
| Pakbaz, S | 1 |
| Azarpira, N | 1 |
| Fang, X | 1 |
| Huang, W | 1 |
| Sun, Q | 1 |
| Zhao, Y | 1 |
| Sun, R | 1 |
| Liu, F | 2 |
| Huang, D | 1 |
| Zhang, Y | 1 |
| Gao, F | 1 |
| Wang, B | 1 |
| Ostadmohammadi, V | 2 |
| Bahmani, F | 2 |
| Aghadavod, E | 2 |
| Ramezani, R | 1 |
| Reiter, RJ | 3 |
| Mansournia, MA | 2 |
| Banikazemi, Z | 1 |
| Soleimani, M | 1 |
| Zaroudi, M | 1 |
| Asemi, Z | 3 |
| Mok, JX | 1 |
| Ooi, JH | 1 |
| Ng, KY | 1 |
| Koh, RY | 1 |
| Chye, SM | 1 |
| Yalçınkaya, AS | 1 |
| Şekeroğlu, MR | 1 |
| Huyut, Z | 1 |
| Çokluk, E | 1 |
| Özbek, H | 1 |
| Öztürk, G | 1 |
| Balahoroğlu, R | 1 |
| Tu, Y | 1 |
| Zhu, M | 1 |
| Wang, Z | 1 |
| Wang, K | 1 |
| Chen, L | 1 |
| Liu, W | 2 |
| Shi, Q | 1 |
| Zhao, Q | 1 |
| Sun, Y | 1 |
| Wang, X | 1 |
| Song, E | 1 |
| Liu, X | 1 |
| Yu, M | 1 |
| Xie, D | 1 |
| Wang, L | 1 |
| Ye, C | 1 |
| Zhu, Q | 1 |
| Yang, L | 1 |
| El-Missiry, MA | 2 |
| El-Missiry, ZMA | 1 |
| Othman, AI | 1 |
| Ramirez, AVG | 1 |
| Filho, DR | 1 |
| de Sá, LBPC | 1 |
| Miller, MA | 1 |
| Cappuccio, FP | 1 |
| Amer, ME | 1 |
| Othamn, AI | 1 |
| Satari, M | 1 |
| Reiner, Z | 1 |
| Kheiripour, N | 1 |
| Pawlikowski, M | 1 |
| Winczyk, K | 1 |
| Guo, C | 1 |
| He, J | 1 |
| Deng, X | 1 |
| Wang, D | 1 |
| Yuan, G | 1 |
| Delpino, FM | 1 |
| Figueiredo, LM | 1 |
| Nunes, BP | 1 |
| Song, J | 1 |
| Whitcomb, DJ | 1 |
| Kim, BC | 1 |
| Carpentieri, AR | 1 |
| Peralta Lopez, ME | 1 |
| Aguilar, J | 1 |
| Solá, VM | 1 |
| Thakur, P | 1 |
| Kumar, A | 2 |
| Ruiz, L | 1 |
| Gurlo, T | 1 |
| Ravier, MA | 1 |
| Wojtusciszyn, A | 1 |
| Mathieu, J | 1 |
| Brown, MR | 1 |
| Broca, C | 1 |
| Bertrand, G | 1 |
| Butler, PC | 1 |
| Matveyenko, AV | 1 |
| Dalle, S | 1 |
| Costes, S | 1 |
| Hardeland, R | 1 |
| Obayashi, K | 3 |
| Yamagami, Y | 1 |
| Iwamoto, J | 2 |
| Kurumatani, N | 3 |
| Saeki, K | 3 |
| Doosti-Irani, A | 1 |
| Mirhosseini, N | 1 |
| Kashanian, M | 1 |
| Rahimi, M | 1 |
| Razavi, M | 1 |
| Ba-Ali, S | 1 |
| Brøndsted, AE | 1 |
| Andersen, HU | 1 |
| Sander, B | 1 |
| Jennum, PJ | 1 |
| Lund-Andersen, H | 1 |
| Cutando, A | 2 |
| López-Valverde, A | 2 |
| Gómez-de-Diego, R | 1 |
| Arias-Santiago, S | 1 |
| de Vicente-Jiménez, J | 1 |
| Peschke, E | 2 |
| Bähr, I | 1 |
| Mühlbauer, E | 1 |
| de Diego, RG | 1 |
| de Vicente, J | 1 |
| Reiter, R | 1 |
| Fernández, MH | 1 |
| Ferrera, MJ | 1 |
| Ikada, Y | 1 |
| Hammer, HF | 1 |
| Majumdar, AS | 1 |
| Giri, PR | 1 |
| Pai, SA | 1 |
| Xie, M | 1 |
| Hu, A | 1 |
| Luo, Y | 1 |
| Sun, W | 1 |
| Hu, X | 1 |
| Tang, S | 1 |
| Jenwitheesuk, A | 1 |
| Nopparat, C | 1 |
| Mukda, S | 1 |
| Wongchitrat, P | 1 |
| Govitrapong, P | 1 |
| Paradies, G | 1 |
| Paradies, V | 1 |
| Ruggiero, FM | 1 |
| Petrosillo, G | 1 |
| Karaaslan, C | 1 |
| Suzen, S | 1 |
| Nieuwenhuis, RF | 1 |
| Spooren, PF | 1 |
| Tilanus, JJ | 1 |
| Agil, A | 1 |
| Navarro-Alarcón, M | 1 |
| Ruiz, R | 1 |
| Abuhamadah, S | 1 |
| El-Mir, MY | 1 |
| Vázquez, GF | 1 |
| Baxi, DB | 1 |
| Singh, PK | 1 |
| Vachhrajani, KD | 1 |
| Ramachandran, AV | 1 |
| Slominski, RM | 1 |
| Schlabritz-Loutsevitch, N | 1 |
| Ostrom, RS | 1 |
| Slominski, AT | 1 |
| Arushanian, ÉB | 1 |
| Lucassen, EA | 1 |
| Rother, KI | 1 |
| Cizza, G | 1 |
| Halmos, T | 1 |
| Suba, I | 1 |
| Rodella, LF | 1 |
| Favero, G | 1 |
| Foglio, E | 1 |
| Rossini, C | 1 |
| Castrezzati, S | 1 |
| Lonati, C | 1 |
| Rezzani, R | 1 |
| Derlacz, RA | 1 |
| Poplawski, P | 1 |
| Napierala, M | 1 |
| Jagielski, AK | 1 |
| Bryla, J | 1 |
| Nishida, S | 1 |
| Haus, E | 1 |
| Conti, A | 1 |
| Maestroni, GJ | 1 |
| O'Brien, IA | 1 |
| Lewin, IG | 1 |
| O'Hare, JP | 1 |
| Arendt, J | 1 |
| Corrall, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: a Multicentre Prospective Cohort Study[NCT05290350] | 300 participants (Anticipated) | Observational | 2022-03-10 | Recruiting | |||
| Circadian Disturbances in People With Mental Disease[NCT05413486] | 86 participants (Anticipated) | Observational | 2022-04-04 | Recruiting | |||
| Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.[NCT03368430] | Phase 4 | 74 participants (Actual) | Interventional | 2016-07-04 | Completed | ||
| Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504] | Phase 4 | 25 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | g (Mean) |
|---|---|
| Ramelteon | 3934.86 |
| Placebo (Sugar Pill) | 5120.92 |
A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | HOMA score (Mean) |
|---|---|
| Ramelteon | 2.4 |
| Placebo (Sugar Pill) | 2.36 |
A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | cm (Mean) |
|---|---|
| Ramelteon | 106.09 |
| Placebo (Sugar Pill) | 108.37 |
27 reviews available for melatonin and Diabetes Mellitus
| Article | Year |
|---|---|
Effects of Melatonin on Diabetic Neuropathy and Retinopathy.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Diabetic Retinopathy; Hum | 2021 |
Salivary Biomarkers Associated with Psychological Alterations in Patients with Diabetes: A Systematic Review.
Topics: Biomarkers; Diabetes Mellitus; Humans; Hydrocortisone; Melatonin; Quality of Life; Saliva; Stress, P | 2022 |
A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.
Topics: Animals; Antioxidants; Diabetes Mellitus; Female; Humans; Male; Melatonin; Mice; Oxidative Stress; R | 2022 |
Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models.
Topics: Animals; Body Weight; Diabetes Mellitus; Hyperthyroidism; Infertility, Male; Male; Melatonin; Metabo | 2023 |
A new prospective on the role of melatonin in diabetes and its complications.
Topics: Animals; Antioxidants; Apoptosis; Cardiomyopathies; Diabetes Complications; Diabetes Mellitus; Diabe | 2019 |
Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19.
Topics: Adjuvants, Immunologic; Antioxidants; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; C | 2020 |
Melatonin and its Relationships with Diabetes and Obesity: A Literature Review.
Topics: Adult; Diabetes Mellitus; Humans; Melatonin; Obesity; Prospective Studies; Randomized Controlled Tri | 2021 |
A systematic review of COVID-19 and obstructive sleep apnoea.
Topics: Comorbidity; Continuous Positive Airway Pressure; COVID-19; Diabetes Mellitus; Humans; Hypertension; | 2021 |
Endocrine and metabolic aspects of COVID-19.
Topics: Aging; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme 2; COVID-19; Diabetes Mellitus; Hu | 2021 |
Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Dietary Supplements; Fasting; Female; Glycated Hemoglobin; | 2021 |
The role of melatonin in the onset and progression of type 3 diabetes.
Topics: Animals; Blood-Brain Barrier; Diabetes Mellitus; Disease Progression; Humans; Insulin Resistance; Me | 2017 |
Melatonin and periodontal tissues: Molecular and clinical perspectives.
Topics: Animals; Bone and Bones; Dental Implants; Diabetes Mellitus; Humans; Melatonin; Mental Disorders; Mo | 2017 |
Targeting oxidative stress through antioxidants in diabetes mellitus.
Topics: Antioxidants; Clinical Trials as Topic; Diabetes Mellitus; Humans; Melatonin; Mitochondria; Oxidativ | 2018 |
Recent Findings in Melatonin Research and Their Relevance to the CNS.
Topics: Animals; Anti-Inflammatory Agents; Biomedical Research; Brain; Diabetes Mellitus; Humans; Hypoglycem | 2018 |
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Blood Glucose; Diabetes Mellitus; Dietary Supplements; Humans; Insulin Resistance; Melatonin; Random | 2018 |
Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon.
Topics: Animals; Diabetes Mellitus; Glucagon; Humans; Insulin; Islets of Langerhans; Melatonin; Receptors, M | 2013 |
An update on pancreatic pathophysiology (do we have to rewrite pancreatic pathophysiology?).
Topics: Cathepsin B; Diabetes Mellitus; DNA Mutational Analysis; Ghrelin; Leptin; Melatonin; Pancreas; Pancr | 2014 |
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Topics: Aging; Animals; Autophagy; Brain; Caloric Restriction; Circadian Rhythm; Diabetes Mellitus; Energy M | 2014 |
Protective role of melatonin in mitochondrial dysfunction and related disorders.
Topics: Animals; Antioxidants; Cardiolipins; Cardiovascular Diseases; Diabetes Mellitus; Humans; Melatonin; | 2015 |
Antioxidant properties of melatonin and its potential action in diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Clinical Trials as Topic; Diabetes Mellitus; Humans | 2015 |
Melatonin membrane receptors in peripheral tissues: distribution and functions.
Topics: Animals; Bone and Bones; Breast; Cardiovascular System; Diabetes Mellitus; Female; Gastrointestinal | 2012 |
[Protective role of melatonin in pancreatic gland disorders].
Topics: Acute Disease; Animals; Central Nervous System Depressants; Diabetes Mellitus; Humans; Melatonin; Pa | 2012 |
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity.
Topics: Adiponectin; Appetite; Diabetes Mellitus; Energy Metabolism; Female; Ghrelin; Glucose; Humans; Insul | 2012 |
[Physiological and pathophysiological role of the circadian clock system].
Topics: Aging; ARNTL Transcription Factors; Blood Coagulation Disorders; Cardiovascular Diseases; Circadian | 2012 |
Metabolic effects of melatonin on oxidative stress and diabetes mellitus.
Topics: Animals; Anticholesteremic Agents; Diabetes Mellitus; Humans; Hypercholesterolemia; Insulin; Melaton | 2005 |
Chronobiology in the endocrine system.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Blood Glucose; Chronobiology Phenomen | 2007 |
Melatonin, endocrine pancreas and diabetes.
Topics: Alloxan; Animals; Biological Clocks; Circadian Rhythm; Diabetes Mellitus; Free Radicals; Glucose; Hu | 2008 |
3 trials available for melatonin and Diabetes Mellitus
| Article | Year |
|---|---|
The effects of melatonin administration on carotid intima-media thickness and pulse wave velocity in diabetic nephropathy: A randomized, double-blind, placebo-controlled trial.
Topics: Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Mellitus; Diabetic Nephropathies; Humans; | 2022 |
The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Biomarkers; Blood Glucose; Cardiovascular | 2020 |
Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus; Diabet | 2021 |
29 other studies available for melatonin and Diabetes Mellitus
| Article | Year |
|---|---|
Melatonin prevents diabetes mellitus-induced bone loss.
Topics: Bone Diseases, Metabolic; Diabetes Mellitus; Humans; Melatonin | 2021 |
A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Anima | 2022 |
Melatonin Maintains Inner Blood-Retinal Barrier by Regulating Microglia
Topics: Animals; Blood-Retinal Barrier; Diabetes Mellitus; Diabetic Retinopathy; Endothelial Cells; Melatoni | 2022 |
Melatonin alleviates renal injury by activating mitophagy in diabetic nephropathy.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus; Diabetic Nephropathies; Inflammation; Kid | 2022 |
Melatonin receptor gene polymorphisms as a risk factor in patients with diabetic peripheral neuropathy.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Genetic Predisposition to Disease; Humans; Melatonin; Poly | 2022 |
Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model.
Topics: Antioxidants; Delayed-Action Preparations; Diabetes Mellitus; Diabetic Retinopathy; Drug Carriers; H | 2022 |
Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets.
Topics: Animals; Cyclin D1; Cyclin D2; Diabetes Mellitus; DNA Methylation; Fathers; Glucose Intolerance; Hum | 2023 |
Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation.
Topics: Animals; Apoptosis; Cellular Senescence; Diabetes Mellitus; Diabetic Nephropathies; Humans; Melatoni | 2023 |
The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: the effect of melatonin and pentoxifylline.
Topics: Animals; Brain; Diabetes Mellitus; Glutathione Peroxidase; Lipid Peroxidation; Melatonin; Mice; Nitr | 2022 |
Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy.
Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus; Diabetic Retinopathy; Ependymoglial Cells; Hypergl | 2020 |
Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway.
Topics: Diabetes Mellitus; Exosomes; Humans; Macrophages; Melatonin; Mesenchymal Stem Cells; Proto-Oncogene | 2020 |
Melatonin ameliorates diabetes-induced brain injury in rats.
Topics: Animals; Blood Glucose; Brain Injuries; Diabetes Mellitus; Immunohistochemistry; Male; Melatonin; Ox | 2021 |
Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress.
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus; Diabetic Nephropathies; Humans; Melatonin; Oxidative | 2023 |
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
Topics: Acetylation; Animals; Apoptosis; Cytokines; Diabetes Mellitus; E1A-Associated p300 Protein; Glucose; | 2018 |
Gender differences in the association between melatonin secretion and diabetes in elderly: The HEIJO-KYO cohort.
Topics: Aged; Circadian Rhythm; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; | 2018 |
Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy.
Topics: Actigraphy; Circadian Rhythm; Diabetes Mellitus; Diabetic Retinopathy; Female; Humans; Hydrocortison | 2019 |
Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease.
Topics: Acid Phosphatase; Administration, Topical; Adult; Aged; Alkaline Phosphatase; Cross-Sectional Studie | 2013 |
Effect of topical application of melatonin to the gingiva on salivary osteoprotegerin, RANKL and melatonin levels in patients with diabetes and periodontal disease.
Topics: Administration, Topical; Adult; Aged; Diabetes Mellitus; Female; Gingiva; Humans; Male; Melatonin; M | 2014 |
Independent associations of exposure to evening light and nocturnal urinary melatonin excretion with diabetes in the elderly.
Topics: Aged; Aged, 80 and over; Biological Clocks; Circadian Rhythm; Cross-Sectional Studies; Diabetes Mell | 2014 |
Resveratrol- and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic alterations in female rats.
Topics: Administration, Oral; Animals; Antioxidants; Diabetes Mellitus; Diet; Disease Models, Animal; Female | 2014 |
Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells.
Topics: Diabetes Mellitus; Down-Regulation; Endothelial Cells; Epithelial Cells; Glucose; Humans; Inflammati | 2014 |
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-S | 2014 |
[Less need for insulin, a surprising effect of phototherapy in insulin-dependent diabetes mellitus].
Topics: Adult; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Humans; Hypoglyce | 2009 |
Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats.
Topics: Animals; Antioxidants; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mel | 2011 |
Neonatal corticosterone programs for thrifty phenotype adult diabetic manifestations and oxidative stress: countering effect of melatonin as a deprogrammer.
Topics: Age of Onset; Animals; Animals, Newborn; Corticosterone; Diabetes Mellitus; Drug Antagonism; Female; | 2012 |
Vascular endothelial cells and dysfunctions: role of melatonin.
Topics: Atherosclerosis; Diabetes Mellitus; Endothelial Cells; Humans; Hypertension; Melatonin; Nicotine; Re | 2013 |
Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules.
Topics: Alanine; Animals; Diabetes Mellitus; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycerol; In | 2005 |
Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice.
Topics: Animals; Animals, Newborn; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus; Female; Insulin; | 1996 |
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy.
Topics: Aged; Autonomic Nervous System Diseases; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Diabeti | 1986 |