melatonin has been researched along with Diabetes Mellitus, Type 2 in 139 studies
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk." | 9.30 | Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. ( Asemi, Z; Bahmani, F; Ostadmohammadi, V; Raygan, F; Reiter, RJ, 2019) |
| "To assess the effect of daily treatment with melatonin on fasting glucose, insulin, insulin sensitivity and haemoglobin A1c (HbA1c) levels." | 9.12 | Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis. ( Kampmann, U; Lauritzen, ES; Smedegaard, SB; Støy, J, 2021) |
| "Recent evidence suggests that diabetic retinopathy (DR) is associated with abnormal melatonin regulation, possibly related to dysfunction of the melanopsin-expressing intrinsically photosensitive retinal ganglion cells." | 8.02 | Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy. ( Chailurkit, LO; Chirakalwasan, N; Gerber, BS; Nimitphong, H; Pinyopodjanard, S; Reutrakul, S; Saetung, S; Sirisreetreerux, S; Sujirakul, T, 2021) |
| " The aim of this study was to determine the association between urinary 6-sulfatoxymelatonin, which is a urinary metabolite of melatonin, and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes." | 8.02 | Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes. ( Maiko, H; Mori, H; Okada, Y; Tanaka, K; Tanaka, Y, 2021) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 7.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| "Both aero-bic exercise and melatonin can improve diabetic osteoporosis, and the effect of both joint intervention is more significant, it may be associated with oxidative stress by increasing the ability of diabetic rats, regulate glucose metabolism in order to effectively reduce the calcium and PTH, improve BMD to alleviate osteoporosis." | 7.85 | [Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats]. ( Jing, HF; Wang, XM, 2017) |
| "Melatonin supplementation in combination with exercise behavior may ameliorate IR, hypertension and exercise performance or fatigue possibly by improving antioxidative activities, hyperlipidemia, inflammatory cytokines via up-regulation of GLUT4, PGC-1 α and mitochondrial biogenesis in T2DM rats." | 7.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus." | 7.83 | Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus. ( Arkhipov, SA; Ishchenko, IY; Klimontov, VV; Konenkov, VI; Michurina, SV; Rachkovskaya, LN; Zavyalov, EL, 2016) |
| "Seventeen male participants with type 2 diabetes completed (1) 3 months of daily melatonin treatment (10 mg) 1 h before bedtime (M) and (2) 3 months of placebo treatment 1 h before bedtime (P)." | 7.11 | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial. ( Christensen, LL; Jessen, N; Kampmann, U; Lauritzen, ES; Møller, N; Pedersen, MGB; Støy, J, 2022) |
| "Melatonin has been suggested to have a role in glucose metabolism, yet the results across studies have been inconsistent." | 6.72 | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Li, Y; Xu, Z, 2021) |
| "Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed." | 5.91 | Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023) |
| "Type 2 diabetes mellitus is often complicated by osteoporosis, a process which may involve osteoblast autophagy." | 5.43 | Melatonin suppresses autophagy in type 2 diabetic osteoporosis. ( Liu, F; Liu, JH; Meng, HZ; Shi, PX; Sun, GH; Yang, B; Yang, MW; Yang, RF; Zhang, WL, 2016) |
| "Melatonin is a powerful antioxidant." | 5.40 | Urinary 6-sulfatoxymelatonin level in diabetic retinopathy patients with type 2 diabetes. ( Cao, H; Chen, W; Lu, QY; Wang, N; Xu, X; Zhao, SZ; Zheng, Z, 2014) |
| "Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk." | 5.30 | Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. ( Asemi, Z; Bahmani, F; Ostadmohammadi, V; Raygan, F; Reiter, RJ, 2019) |
| " This review article aimed to present the role of melatonin in this direction, by providing an overview of melatonin's physiology followed by its effect as a therapeutic agent in arterial hypertension and T2DM." | 5.22 | The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal? ( Kalaitzidis, RG; Theofilis, P; Vordoni, A, 2022) |
| "To assess the effect of daily treatment with melatonin on fasting glucose, insulin, insulin sensitivity and haemoglobin A1c (HbA1c) levels." | 5.12 | Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis. ( Kampmann, U; Lauritzen, ES; Smedegaard, SB; Støy, J, 2021) |
| " There has also been a marked increase in the prevalence of metabolic syndrome in recent decades, which has been associated with a reduction in nocturnal pineal production of melatonin with aging and an increased risk of coronary diseases, type 2 diabetes mellitus (T2DM) and death." | 4.90 | Melatonin and metabolic regulation: a review. ( A-Serrano, MM; Acuña-Castroviejo, D; Agil, A; Blanca-Herrera, RM; Fernández-Vázquez, G; Navarro-Alarcón, M; Ruiz-Ojeda, FJ, 2014) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; 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Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; 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Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
| "The pretreatment of hUC-MSCs with melatonin partly boosted cell efficiency and thereby alleviated impaired glycemic control and insulin resistance." | 4.12 | Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. ( Aierken, A; Cheng, X; Du, X; Enkhbaatar, BB; He, X; Hua, J; Jia, W; Kou, Z; Li, B; Li, N; Liu, P; Peng, S; Shen, Q; Tan, N; Wang, C; Wang, R; Wu, X; Yu, S; Zhang, J; Zhang, M; Zhang, R, 2022) |
| "Recent evidence suggests that diabetic retinopathy (DR) is associated with abnormal melatonin regulation, possibly related to dysfunction of the melanopsin-expressing intrinsically photosensitive retinal ganglion cells." | 4.02 | Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy. ( Chailurkit, LO; Chirakalwasan, N; Gerber, BS; Nimitphong, H; Pinyopodjanard, S; Reutrakul, S; Saetung, S; Sirisreetreerux, S; Sujirakul, T, 2021) |
| " The aim of this study was to determine the association between urinary 6-sulfatoxymelatonin, which is a urinary metabolite of melatonin, and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes." | 4.02 | Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes. ( Maiko, H; Mori, H; Okada, Y; Tanaka, K; Tanaka, Y, 2021) |
| " This is due to hyperglycemia, the higher prevalence of sleep disorders and also the low levels of melatonin, a substance with anti-inflammatory actions, in these patients." | 4.02 | Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus. ( Martorina, WJ; Tavares, A, 2021) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 3.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| "Both aero-bic exercise and melatonin can improve diabetic osteoporosis, and the effect of both joint intervention is more significant, it may be associated with oxidative stress by increasing the ability of diabetic rats, regulate glucose metabolism in order to effectively reduce the calcium and PTH, improve BMD to alleviate osteoporosis." | 3.85 | [Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats]. ( Jing, HF; Wang, XM, 2017) |
| "Melatonin supplementation in combination with exercise behavior may ameliorate IR, hypertension and exercise performance or fatigue possibly by improving antioxidative activities, hyperlipidemia, inflammatory cytokines via up-regulation of GLUT4, PGC-1 α and mitochondrial biogenesis in T2DM rats." | 3.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus." | 3.83 | Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus. ( Arkhipov, SA; Ishchenko, IY; Klimontov, VV; Konenkov, VI; Michurina, SV; Rachkovskaya, LN; Zavyalov, EL, 2016) |
| "The aim of this study was to investigate the effects of melatonin on glucose homeostasis in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 3.78 | Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats. ( Agil, A; Fernández-Vázquez, G; Figueroa, A; Rosado, I; Ruiz, R; Zen, N, 2012) |
| "Glycemic variability in patients with type 2 diabetes mellitus (T2DM) may be associated with chronic complications of the disease." | 3.30 | Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study. ( Martorina, W; Tavares, A, 2023) |
| "Melatonin serum levels were 3." | 3.11 | Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. ( Baraza, JC; Dashti, HS; Florez, JC; Garaulet, M; Hernández-Martínez, AM; Lopez-Minguez, J; Pérez-Ayala, M; Saxena, R; Scheer, FAJL; Vetter, C; Wang, W, 2022) |
| "Seventeen male participants with type 2 diabetes completed (1) 3 months of daily melatonin treatment (10 mg) 1 h before bedtime (M) and (2) 3 months of placebo treatment 1 h before bedtime (P)." | 3.11 | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial. ( Christensen, LL; Jessen, N; Kampmann, U; Lauritzen, ES; Møller, N; Pedersen, MGB; Støy, J, 2022) |
| "Melatonin was also well tolerated." | 3.01 | Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial. ( Mehrpooya, M; Mohammadi, Y; Sajedi, F; Shokri, M, 2021) |
| "Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age-related, and most of these diseases are comorbidities or risk factors for AD; however, our understandings of molecular events that regulate the occurrence of these diseases are still not fully understood." | 2.82 | Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions. ( Chen, J; Dong, K; Fan, R; Ma, D; Peng, X; Shi, X; Xie, L; Xu, W; Yang, Y; Yu, X; Zhang, S, 2022) |
| "Melatonin has been suggested to have a role in glucose metabolism, yet the results across studies have been inconsistent." | 2.72 | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Li, Y; Xu, Z, 2021) |
| "The prevalence of type 2 diabetes is increased in individuals with mental disorders." | 2.72 | Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries. ( Ajjan, RA; Al Azdi, Z; Aslam, F; Churchill, R; Mishu, MP; Philip, S; Siddiqi, N; Stubbs, B; Tirbhowan, N; Uphoff, E; Wright, J, 2021) |
| "Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes." | 2.66 | The roles of melatonin on kidney injury in obese and diabetic conditions. ( Lungkaphin, A; Promsan, S, 2020) |
| " Despite intensive investigation, there is considerable confusion and seemingly conflicting data on the metabolic effects of melatonin and MTNR1B variation, and disagreement on whether melatonin is metabolically beneficial or deleterious, a crucial issue for melatonin agonist/antagonist drug development and dosing time." | 2.66 | Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. ( Arendt, J; Florez, JC; Garaulet, M; Qian, J; Saxena, R; Scheer, FAJL, 2020) |
| "Individuals with type 2 diabetes mellitus have lower night-time serum melatonin levels and increased risk of comorbid sleep disturbances compared with healthy individuals." | 2.55 | Chronomedicine and type 2 diabetes: shining some light on melatonin. ( Forrestel, AC; Miedlich, SU; Sellix, MT; Wittlin, SD; Yurcheshen, M, 2017) |
| "The incidence of both type 2 diabetes (T2DM) and cancer is increasing worldwide, making these diseases a global health problem along with increasing healthcare expenditures." | 2.55 | Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer. ( Cypryk, K; Krawczyk, M; Wojcik, M; Wojcik, P; Wozniak, LA, 2017) |
| "Melatonin is a multifunctional indoleamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity." | 2.48 | Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. ( Korkmaz, A; Ma, S; Reiter, RJ; Rosales-Corral, S; Tan, DX; Topal, T, 2012) |
| "Type 2 diabetes is a metabolic disease, which frequency increases substantially with age." | 2.46 | [Melatonin and oxidative stress in elderly patients with type 2 diabetes]. ( Kedziora, J; Kedziora-Kornatowska, K; Kupczyk, D; Rybka, J, 2010) |
| "The incidence of type 2 diabetes mellitus has markedly increased worldwide over the past decades." | 2.46 | Genetic variants in MTNR1B affecting insulin secretion. ( Fritsche, A; Häring, HU; Machicao, F; Müssig, K; Staiger, H, 2010) |
| "Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD." | 2.40 | GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus. ( Das, UN, 1999) |
| "Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed." | 1.91 | Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023) |
| "The pathogenesis of type 2 diabetes (T2D) is highly related to the abnormal self-assembly of the human islet amyloid polypeptide (hIAPP) into amyloid aggregates." | 1.72 | Melatonin Inhibits hIAPP Oligomerization by Preventing β-Sheet and Hydrogen Bond Formation of the Amyloidogenic Region Revealed by Replica-Exchange Molecular Dynamics Simulation. ( Qian, Z; Song, X; Wang, G; Zhang, Q; Zhu, X, 2022) |
| "Individuals with type 2 diabetes (cases) and healthy individuals (controls) (n=2034) were recruited from a cross-sectional study and were matched for age and sex in a case-control study." | 1.72 | Gut microbiota mediate melatonin signalling in association with type 2 diabetes. ( An, Z; Chen, W; Deng, Y; Gao, Y; He, Z; Hu, Q; Huang, X; Lin, R; Lv, Y; Mo, Z; Qiu, Y; Wang, X; Zhang, H; Zhou, R, 2022) |
| "People with type 2 diabetes (T2D) suffer from sleep disorders, with the mechanism not clearly understood." | 1.62 | Supplemental light exposure improves sleep architecture in people with type 2 diabetes. ( Adhikari, P; Feigl, B; Pradhan, A; Zele, AJ, 2021) |
| "Melatonin level was evaluated by measuring 24-hour urine 6-sulfatoxymelatonin levels." | 1.62 | Presence of Peripheral Neuropathy Does Not Affect Urine 6-Sulfatoxymelatonin Levels in Type 2 Diabetics. ( Cakin, S; Karakılıç, E; Kurt, K; Ocak, O, 2021) |
| "Melatonin was decreased (124." | 1.48 | Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions. ( Brković, B; DJukić, L; DŽeletović, B; Milašin, J; Milosavljević, A; Roganović, J; Toljić, B, 2018) |
| "Melatonin was estimated from plasma samples by ELISA." | 1.48 | Association of melatonin &MTNR1B variants with type 2 diabetes in Gujarat population. ( Begum, R; Palit, SP; Patel, R; Ramachandran, AV; Rathwa, N, 2018) |
| "Obstructive sleep apnea was diagnosed using an ambulatory device." | 1.46 | Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes. ( Chailurkit, LO; Chirakalwasan, N; Nimitphong, H; Ongphiphadhanakul, B; Reutrakul, S; Saetung, S; Siwasaranond, N; Srijaruskul, K; Thakkinstian, A, 2017) |
| "The risk of type 2 diabetes (T2D) is increased by abnormalities in sleep quantity and quality, circadian alignment, and melatonin regulation." | 1.43 | Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. ( Aeschbach, D; Anderson, C; Bjonnes, AC; Buxton, OM; Cade, BE; Cain, SW; Chang, AM; Czeisler, CA; Duffy, JF; Gharib, SA; Gooley, JJ; Gottlieb, DJ; Grant, SF; Klerman, EB; Lane, JM; Lauderdale, DS; Lockley, SW; Munch, M; Patel, S; Punjabi, NM; Rajaratnam, SM; Redline, S; Rueger, M; Santhi, N; Saxena, R; Scheer, FA; Scheuermaier, K; Shea, SA; St Hilaire, MA; Van Reen, E; Zee, PC, 2016) |
| "Melatonin was administered (10 mg/kg/day) by gavage for 24 weeks." | 1.43 | Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation. ( Fan, T; Gui, S; Hu, R; Su, H; Tang, S; Wang, Y; Yang, X; Zhou, Q; Zou, D; Zuo, L, 2016) |
| "Melatonin treatment in a human recall-by-genotype study reduced insulin secretion and raised glucose levels more extensively in risk G-allele carriers." | 1.43 | Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. ( Alenkvist, I; Almgren, P; Asplund, O; Bennet, H; Fadista, J; Fex, M; Forsén, T; Groop, L; Hakaste, L; Isomaa, B; Martikainen, S; Mulder, H; Nagorny, CLF; Östman, B; Pesonen, AK; Räikkönen, K; Shcherbina, L; Singh, P; Söderström, J; Storm, P; Tengholm, A; Tuomi, T; Wierup, N; Yu, Q, 2016) |
| "Type 2 diabetes mellitus is often complicated by osteoporosis, a process which may involve osteoblast autophagy." | 1.43 | Melatonin suppresses autophagy in type 2 diabetic osteoporosis. ( Liu, F; Liu, JH; Meng, HZ; Shi, PX; Sun, GH; Yang, B; Yang, MW; Yang, RF; Zhang, WL, 2016) |
| "Melatonin plays a protective role in type 2 diabetes (T2D) through regulation of glucose metabolism." | 1.42 | Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats. ( Li, S; McCabe, MF; Rong, P; Wang, S; Wang, X; Zhai, X, 2015) |
| "Melatonin is a powerful antioxidant." | 1.40 | Urinary 6-sulfatoxymelatonin level in diabetic retinopathy patients with type 2 diabetes. ( Cao, H; Chen, W; Lu, QY; Wang, N; Xu, X; Zhao, SZ; Zheng, Z, 2014) |
| "It plays a key role in type 1 and type 2 diabetes." | 1.39 | Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice. ( Fischer, C; Korf, HW; Shalabi, A; von Gall, C, 2013) |
| "Melatonin has a protective role in type 2 diabetes; however, its synthesis itself is affected in the disease." | 1.36 | Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats. ( Bach, AG; Mühlbauer, E; Peschke, E, 2010) |
| "Melatonin was given daily during the dark period for 12 hr." | 1.36 | Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats. ( Mühlbauer, E; Peschke, E; Schucht, H, 2010) |
| "Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity." | 1.35 | Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Kozakiewicz, M; Pawluk, H; Szewczyk-Golec, K, 2009) |
| "Melatonin dynamics were re-evaluated with respect to autonomic nervous system in diabetic patients with autonomic neuropathy who were diagnosed by the cardiovascular reflex tests, heart rate variability (HRV), and 24-hr blood pressure monitoring." | 1.33 | Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy. ( Aksoyek, S; Batur, MK; Deger, A; Erbas, B; Erbas, T; Kabakci, G; Koray, Z; Tutuncu, NB; Tutuncu, T; Yildirir, A, 2005) |
| "Melatonin plays several important physiological functions in mammals, such as immune enhancement and regulation of dark-light signal transduction." | 1.32 | The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts. ( Bryszewska, M; Kilańczyk, E, 2003) |
| "Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD." | 1.30 | GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity. ( Das, UN, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (2.16) | 18.2507 |
| 2000's | 12 (8.63) | 29.6817 |
| 2010's | 71 (51.08) | 24.3611 |
| 2020's | 53 (38.13) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 10 |
| Xu, Z | 1 |
| Li, X | 11 |
| He, J | 1 |
| Zhou, Y | 1 |
| Cai, S | 1 |
| Xue, P | 1 |
| Tan, X | 1 |
| Wu, J | 1 |
| Tang, X | 1 |
| Benedict, C | 1 |
| Huang, K | 1 |
| Luo, X | 1 |
| Zhong, Y | 1 |
| Deng, L | 2 |
| Feng, J | 2 |
| Patel, R | 3 |
| Parmar, N | 2 |
| Pramanik Palit, S | 1 |
| Rathwa, N | 3 |
| Ramachandran, AV | 2 |
| Begum, R | 3 |
| Nikolaev, G | 1 |
| Robeva, R | 1 |
| Konakchieva, R | 1 |
| Peng, X | 2 |
| Fan, R | 2 |
| Xie, L | 2 |
| Shi, X | 2 |
| Dong, K | 2 |
| Zhang, S | 2 |
| Tao, J | 1 |
| Xu, W | 2 |
| Ma, D | 2 |
| Chen, J | 4 |
| Yang, Y | 6 |
| Garaulet, M | 3 |
| Lopez-Minguez, J | 1 |
| Dashti, HS | 1 |
| Vetter, C | 1 |
| Hernández-Martínez, AM | 1 |
| Pérez-Ayala, M | 1 |
| Baraza, JC | 1 |
| Wang, W | 1 |
| Florez, JC | 2 |
| Scheer, FAJL | 3 |
| Saxena, R | 4 |
| Shen, S | 2 |
| Liao, Q | 1 |
| Wong, YK | 1 |
| Chen, X | 3 |
| Yang, C | 3 |
| Xu, C | 1 |
| Sun, J | 3 |
| Wang, J | 7 |
| Park, J | 1 |
| Kim, J | 2 |
| Yun, Y | 1 |
| Han, DH | 1 |
| Kim, K | 1 |
| Hong, J | 1 |
| Cho, S | 1 |
| Aierken, A | 1 |
| Li, B | 2 |
| Liu, P | 1 |
| Cheng, X | 1 |
| Kou, Z | 1 |
| Tan, N | 1 |
| Zhang, M | 2 |
| Yu, S | 2 |
| Shen, Q | 1 |
| Du, X | 1 |
| Enkhbaatar, BB | 1 |
| Zhang, J | 3 |
| Zhang, R | 3 |
| Wu, X | 1 |
| Wang, R | 1 |
| He, X | 1 |
| Li, N | 2 |
| Peng, S | 2 |
| Jia, W | 1 |
| Wang, C | 1 |
| Hua, J | 1 |
| Lauritzen, ES | 2 |
| Kampmann, U | 2 |
| Pedersen, MGB | 1 |
| Christensen, LL | 1 |
| Jessen, N | 1 |
| Møller, N | 1 |
| Støy, J | 2 |
| Parravano, M | 1 |
| Eandi, CM | 1 |
| Figus, M | 1 |
| Lupidi, M | 1 |
| Menchini, F | 1 |
| Nicolo, M | 1 |
| Parisi, V | 1 |
| Toto, L | 1 |
| Viola, F | 1 |
| Vujosevic, S | 1 |
| Querques, G | 1 |
| Gheban, BA | 1 |
| Colosi, HA | 1 |
| Gheban-Roșca, IA | 1 |
| Georgiu, C | 1 |
| Gheban, D | 1 |
| Crișan, D | 1 |
| Crișan, M | 1 |
| Theofilis, P | 1 |
| Vordoni, A | 1 |
| Kalaitzidis, RG | 1 |
| Huang, X | 1 |
| Qiu, Y | 2 |
| Gao, Y | 2 |
| Zhou, R | 1 |
| Hu, Q | 1 |
| He, Z | 1 |
| Lv, Y | 1 |
| Wang, X | 4 |
| Chen, W | 2 |
| Deng, Y | 1 |
| An, Z | 1 |
| Zhang, H | 1 |
| Mo, Z | 1 |
| Lin, R | 1 |
| Yu, X | 2 |
| Wang, G | 1 |
| Zhu, X | 1 |
| Song, X | 1 |
| Zhang, Q | 2 |
| Qian, Z | 1 |
| Maity, J | 3 |
| Dey, T | 3 |
| Banerjee, A | 3 |
| Chattopadhyay, A | 3 |
| Das, AR | 3 |
| Bandyopadhyay, D | 3 |
| Su, S | 2 |
| Zhao, Q | 3 |
| Dan, L | 2 |
| Lin, Y | 3 |
| Zhang, Y | 8 |
| Dong, Y | 3 |
| Regazzi, R | 2 |
| Sun, C | 2 |
| Chu, X | 2 |
| Lu, H | 3 |
| Palit, SP | 2 |
| Ilić, J | 1 |
| Milosavljević, A | 2 |
| Lazarević, M | 1 |
| Milošević Marković, M | 1 |
| Milašin, J | 3 |
| Vučetić, M | 1 |
| Chaurasia, A | 1 |
| Miletić, V | 1 |
| Roganović, J | 3 |
| Mokhtari, B | 1 |
| Høilund-Carlsen, PF | 1 |
| Chodari, L | 1 |
| Yasami, M | 1 |
| Badalzadeh, R | 1 |
| Ghaffari, S | 1 |
| Zhu, H | 4 |
| Zhao, ZJ | 2 |
| Liu, HY | 2 |
| Cai, J | 1 |
| Lu, QK | 1 |
| Ji, LD | 2 |
| Xu, J | 2 |
| Xia, AY | 1 |
| Wang, PH | 1 |
| Böhm, A | 1 |
| Lauko, V | 1 |
| Dostalova, K | 1 |
| Balanova, I | 1 |
| Varga, I | 1 |
| Bezak, B | 1 |
| Jajcay, N | 1 |
| Moravcik, R | 1 |
| Lazurova, L | 1 |
| Slezak, P | 1 |
| Mojto, V | 1 |
| Kollarova, M | 1 |
| Petrikova, K | 1 |
| Danova, K | 1 |
| Zeman, M | 1 |
| Amin, M | 1 |
| Gragnoli, C | 1 |
| Song, Z | 1 |
| Yan, C | 1 |
| Zhan, Y | 1 |
| Wang, Q | 1 |
| Jiang, T | 1 |
| Watanabe, K | 1 |
| Nakano, M | 1 |
| Maruyama, Y | 1 |
| Hirayama, J | 1 |
| Suzuki, N | 1 |
| Hattori, A | 1 |
| Zhang, YZ | 1 |
| Xin, C | 1 |
| Zhang, ZX | 1 |
| Zhang, KQ | 1 |
| Li, L | 2 |
| Rong, PJ | 1 |
| Li, SY | 1 |
| Martorina, W | 1 |
| Tavares, A | 2 |
| Wilson, JB | 1 |
| Epstein, M | 1 |
| Lopez, B | 1 |
| Brown, AK | 1 |
| Lutfy, K | 1 |
| Friedman, TC | 1 |
| Roberts, FL | 1 |
| Cataldo, LR | 1 |
| Fex, M | 2 |
| Barać, M | 1 |
| Petrović, M | 1 |
| Petrović, N | 1 |
| Nikolić-Jakoba, N | 1 |
| Aleksić, Z | 1 |
| Todorović, L | 1 |
| Petrović-Stanojević, N | 1 |
| Anđelić-Jelić, M | 1 |
| Davidović, A | 1 |
| Luo, N | 1 |
| Wang, Y | 7 |
| Ma, Y | 1 |
| Liu, Y | 3 |
| Liu, Z | 1 |
| Park, JH | 1 |
| Seo, I | 1 |
| Shim, HM | 1 |
| Cho, H | 1 |
| Qian, J | 2 |
| Arendt, J | 1 |
| Reutrakul, S | 3 |
| Crowley, SJ | 1 |
| Park, JC | 1 |
| Chau, FY | 1 |
| Priyadarshini, M | 1 |
| Hanlon, EC | 1 |
| Danielson, KK | 1 |
| Gerber, BS | 2 |
| Baynard, T | 1 |
| Yeh, JJ | 1 |
| McAnany, JJ | 1 |
| Maher, AM | 1 |
| Saleh, SR | 1 |
| Elguindy, NM | 1 |
| Hashem, HM | 1 |
| Yacout, GA | 1 |
| Promsan, S | 1 |
| Lungkaphin, A | 1 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
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| Yildirir, A | 1 |
| Tutuncu, T | 1 |
| Deger, A | 1 |
| Koray, Z | 1 |
| Erbas, B | 1 |
| Kabakci, G | 1 |
| Aksoyek, S | 1 |
| Erbas, T | 1 |
| Chankiewitz, E | 1 |
| Peschke, D | 1 |
| Preiss, U | 1 |
| Schneyer, U | 1 |
| Spessert, R | 1 |
| Kadhim, HM | 1 |
| Ismail, SH | 2 |
| Hussein, KI | 2 |
| Bakir, IH | 1 |
| Sahib, AS | 2 |
| Khalaf, BH | 2 |
| Hussain, SA | 2 |
| Khadim, HM | 1 |
| Stumpf, I | 2 |
| Bazwinsky, I | 1 |
| Litvak, L | 1 |
| Dralle, H | 1 |
| Roush, W | 1 |
| Das, UN | 2 |
| Nishida, S | 1 |
| Segawa, T | 1 |
| Murai, I | 1 |
| Nakagawa, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population[NCT03036592] | 1,000 participants (Anticipated) | Interventional | 2017-01-01 | Recruiting | |||
| Effects of Time-Restricted Fasting on the Postprandial Glycemic Responses in Chinese Adults: A Randomized Crossover Study[NCT05913635] | 36 participants (Actual) | Interventional | 2022-09-01 | Active, not recruiting | |||
| Association of Anesthesia Technique With Morbidity and Mortality in Patients With COVID-19 and Surgery for Hip Fracture: a Retrospective Population Cohort Study[NCT05133648] | 1,000 participants (Anticipated) | Observational | 2023-01-05 | Active, not recruiting | |||
| A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome[NCT05939453] | 30 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation[NCT04547439] | Phase 2 | 36 participants (Anticipated) | Interventional | 2021-02-03 | Recruiting | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| Does Melatonin Treatment Affect Glucose Tolerance Among Individuals With a Variant (rs10830963) of the Melatonin Receptor 1B (MTNR1B) Gene?[NCT01705639] | Phase 3 | 45 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Association Between Plasma Melatonin and No-reflow[NCT03306303] | 1,700 participants (Actual) | Observational | 2014-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
40 reviews available for melatonin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperinsulinism; Insulin; Insu | 2021 |
New insights into the role of melatonin in diabetic cardiomyopathy.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Endoplasmic Reticulum Stress; Humans; | 2022 |
Diabetes mellitus and melatonin: Where are we?
Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Insulin; Melatonin; Oxidative Stress | 2022 |
Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease.
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus, Type 2; Humans; Melatonin; Neoplasms; Receptors, G- | 2021 |
A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Melatonin | 2022 |
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Type 2; Humans; Inflam | 2022 |
The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?
Topics: Diabetes Mellitus, Type 2; Humans; Hypertension; Melatonin; Renal Insufficiency, Chronic; Renin-Angi | 2022 |
Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions.
Topics: Adiponectin; Aging; Alzheimer Disease; ARNTL Transcription Factors; Diabetes Mellitus, Type 2; Human | 2022 |
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cholesterol; Diabetes Mellitus, Type 2; Humans; M | 2023 |
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cholesterol; Diabetes Mellitus, Type 2; Humans; M | 2023 |
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cholesterol; Diabetes Mellitus, Type 2; Humans; M | 2023 |
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cholesterol; Diabetes Mellitus, Type 2; Humans; M | 2023 |
The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.
Topics: Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Genome-Wide Association Study; Humans; M | 2023 |
Molecular Mechanisms of the Melatonin Receptor Pathway Linking Circadian Rhythm to Type 2 Diabetes Mellitus.
Topics: Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Insulin Secretion; Melatonin; Receptor, Melaton | 2023 |
The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression.
Topics: Adolescent; Depression; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Feedback; Humans; Imm | 2023 |
Monoamines' role in islet cell function and type 2 diabetes risk.
Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin-Secreting Cells; Melatonin; Serotonin | 2023 |
Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Circadian Rhythm; Diabetes Mellitus, Type 2; Geneti | 2020 |
The roles of melatonin on kidney injury in obese and diabetic conditions.
Topics: Adipocytes; Adipose Tissue; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytokines; D | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antioxidants; Antipsychotic Agents; Blood Glucose; Bo | 2021 |
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Glucose; Glycated Hemoglobin; Humans; Insu | 2021 |
In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update.
Topics: Catecholamines; Diabetes Mellitus, Type 2; Humans; Melatonin; Metabolomics; Neurodegenerative Diseas | 2017 |
Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Diabetes Mellitus, Type 2; | 2017 |
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Genome-Wide Association Study; Humans; Insulin | 2017 |
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases.
Topics: Alzheimer Disease; Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug | 2018 |
Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Melatonin; Oxidative | 2019 |
Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes.
Topics: Adipose Tissue, Beige; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diabetes Mellitus, Typ | 2019 |
Melatonin in type 2 diabetes mellitus and obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Genetic Variation; Genome-Wi | 2019 |
Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diet; Dietary Fiber; Gastrointestinal Microbiome; Humans; | 2019 |
Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 2; Glucose; Humans; Melatonin; Mice; Molecular | 2013 |
Melatonin and glucose metabolism: clinical relevance.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucose; Homeostasis; Humans; Insulin; Insulin Secretion; Melat | 2014 |
Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease.
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Melatonin; Mic | 2014 |
Melatonin and metabolic regulation: a review.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hyperglycemia; M | 2014 |
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gluc | 2015 |
The role of melatonin in diabetes: therapeutic implications.
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Secretion; I | 2015 |
Circadian System and Glucose Metabolism: Implications for Physiology and Disease.
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Glucose; Humans; Melatonin; Sleep | 2016 |
Melatonin and the pathologies of weakened or dysregulated circadian oscillators.
Topics: Animals; Biological Clocks; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; | 2017 |
Chronomedicine and type 2 diabetes: shining some light on melatonin.
Topics: Circadian Rhythm; Diabetes Mellitus, Type 2; Glucose; Humans; Melatonin; Sleep | 2017 |
[Melatonin and oxidative stress in elderly patients with type 2 diabetes].
Topics: Aged; Aging; Antioxidants; Diabetes Mellitus, Type 2; Free Radicals; Humans; Melatonin; Oxidative St | 2010 |
Genetic variants in MTNR1B affecting insulin secretion.
Topics: Animals; Diabetes Mellitus, Type 2; Genetic Variation; Humans; Insulin; Insulin Secretion; Insulin-S | 2010 |
Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Diabetes Mellitus, Type | 2012 |
Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story?
Topics: Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Genetic Variation; Humans; Insulin; Insulin Sec | 2012 |
GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus.
Topics: Caenorhabditis elegans Proteins; Diabetes Mellitus, Type 2; Fatty Acids, Essential; Glucose; Glucose | 1999 |
11 trials available for melatonin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Genotype; Glucose; Humans; Ins | 2022 |
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Genotype; Glucose; Humans; Ins | 2022 |
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Genotype; Glucose; Humans; Ins | 2022 |
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Genotype; Glucose; Humans; Ins | 2022 |
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose; Humans; | 2022 |
Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Melatonin; Prospective Studie | 2023 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease.
Topics: Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycemic Control; Humans; Melatonin; Root Planing | 2021 |
Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial.
Topics: Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dietar | 2021 |
Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial.
Topics: Aged; Analgesics; Central Nervous System Depressants; Comorbidity; Diabetes Mellitus, Type 2; Diabet | 2021 |
Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Antioxidants; Biomarkers; Blood Glucose; Blood Pressure; C-Reactive Protein | 2019 |
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled t
Topics: Biomarkers; C-Reactive Protein; Chronic Periodontitis; Dental Plaque Index; Diabetes Mellitus, Type | 2019 |
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled t
Topics: Biomarkers; C-Reactive Protein; Chronic Periodontitis; Dental Plaque Index; Diabetes Mellitus, Type | 2019 |
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled t
Topics: Biomarkers; C-Reactive Protein; Chronic Periodontitis; Dental Plaque Index; Diabetes Mellitus, Type | 2019 |
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled t
Topics: Biomarkers; C-Reactive Protein; Chronic Periodontitis; Dental Plaque Index; Diabetes Mellitus, Type | 2019 |
Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin.
Topics: Adult; Albuminuria; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug | 2006 |
Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin.
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glycated Hemoglobin; Hu | 2006 |
89 other studies available for melatonin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2021 |
No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients.
Topics: Alleles; Blood Glucose; Child; Diabetes Mellitus, Type 2; Humans; Melatonin; Polymorphism, Single Nu | 2022 |
Daily injection of melatonin inhibits insulin resistance induced by chronic mealtime shift.
Topics: Animals; Diabetes Mellitus, Type 2; Insulin Resistance; Meals; Melatonin; Mice; Reactive Oxygen Spec | 2022 |
Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.
Topics: Animals; bcl-2-Associated X Protein; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Melatoni | 2022 |
Effects of circadian rhythm disruption on retinal physiopathology: Considerations from a consensus of experts.
Topics: Animals; Circadian Rhythm; Consensus; Diabetes Mellitus, Type 2; Humans; Melatonin; Mice; Retina | 2022 |
Digital histological morphometry of the human pineal gland in a postmortem study, with endocrine and neurological clinical implications.
Topics: Adenoma; Animals; Diabetes Mellitus, Type 2; Female; Humans; Male; Melatonin; Pineal Gland; Retrospe | 2023 |
Gut microbiota mediate melatonin signalling in association with type 2 diabetes.
Topics: Biomarkers; Case-Control Studies; Chromatography, Liquid; Cross-Sectional Studies; Diabetes Mellitus | 2022 |
Melatonin Inhibits hIAPP Oligomerization by Preventing β-Sheet and Hydrogen Bond Formation of the Amyloidogenic Region Revealed by Replica-Exchange Molecular Dynamics Simulation.
Topics: Amyloid; Amyloidogenic Proteins; Diabetes Mellitus, Type 2; Humans; Hydrogen Bonding; Islet Amyloid | 2022 |
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa.
Topics: Animals; Cellular Senescence; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Maf Transcription | 2022 |
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa.
Topics: Animals; Cellular Senescence; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Maf Transcription | 2022 |
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa.
Topics: Animals; Cellular Senescence; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Maf Transcription | 2022 |
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa.
Topics: Animals; Cellular Senescence; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Maf Transcription | 2022 |
A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucose; Hypo | 2023 |
Melatonin Mitigates iNOS-Related Effects of HEMA and Camphorquinone in Human Dental Pulp Cells: Relevance for Postoperative Sensitivity Mechanism in Type 2 Diabetes.
Topics: Antioxidants; Dental Pulp; Diabetes Mellitus, Type 2; Humans; Melatonin; Methacrylates; Nitric Oxide | 2023 |
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Infarction; Ischemia; Male; Mel | 2023 |
In-vitro antiplatelet effect of melatonin in healthy individuals and patients with type 2 diabetes mellitus.
Topics: Adenosine Diphosphate; Blood Platelets; Diabetes Mellitus, Type 2; Humans; Melatonin; Myocardial Inf | 2023 |
Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families.
Topics: Diabetes Mellitus, Type 2; Genotype; Humans; Melatonin; Polymorphism, Single Nucleotide; Receptor, M | 2023 |
Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lung; Melatonin; Mit | 2023 |
Nocturnal melatonin increases glucose uptake via insulin-independent action in the goldfish brain.
Topics: Animals; Brain; Diabetes Mellitus, Type 2; Glucose; Goldfish; Melatonin | 2023 |
[Mechanism of melatonin-mediated antihyperglycemic effect of transcutaneous auricular vagus nerve stimulation].
Topics: Animals; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Male; Melatonin; Rats; Rats, Zucker; Recept | 2023 |
Melatonin Action in Type 2 Diabetic Parotid Gland and Dental Pulp: In Vitro and Bioinformatic Findings.
Topics: Computational Biology; Dental Pulp; Diabetes Mellitus, Type 2; Glial Cell Line-Derived Neurotrophic | 2023 |
Melatonin alleviates renal injury in diabetic rats by regulating autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2023 |
Melatonin ameliorates SGLT2 inhibitor-induced diabetic ketoacidosis by inhibiting lipolysis and hepatic ketogenesis in type 2 diabetic mice.
Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic | 2020 |
Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy.
Topics: Adie Syndrome; Aged; Cells, Cultured; Circadian Clocks; Cross-Sectional Studies; Diabetes Mellitus, | 2020 |
Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Diabetes Mellitus, | 2020 |
Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; Male; | 2021 |
Topics: Acute Coronary Syndrome; Adolescent; Adsorption; Adult; Aged; Animals; Aspergillus; Aspergillus oryz | 2021 |
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2021 |
Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes.
Topics: Adult; Aged; Arteriosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; F | 2021 |
Supplemental light exposure improves sleep architecture in people with type 2 diabetes.
Topics: Circadian Rhythm; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; Melatonin; Sleep | 2021 |
Presence of Peripheral Neuropathy Does Not Affect Urine 6-Sulfatoxymelatonin Levels in Type 2 Diabetics.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Melatonin; Oxidative Stress | 2021 |
Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus.
Topics: COVID-19; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Melatonin; SARS-CoV-2 | 2021 |
The case for too little melatonin signalling in increased diabetes risk.
Topics: Diabetes Mellitus, Type 2; Genome-Wide Association Study; Humans; Melatonin; Polymorphism, Single Nu | 2017 |
Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats.
Topics: Animals; Blood Glucose; Brain; Circadian Rhythm; Diabetes Mellitus, Type 2; Glucose Tolerance Test; | 2017 |
Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fatigue; Hypertension; I | 2017 |
Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway.
Topics: Animals; Butadienes; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; | 2018 |
Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands.
Topics: Aged; Diabetes Mellitus, Type 2; Humans; Immunohistochemistry; Male; Melatonin; Salivary Glands | 2018 |
FEATURES OF EXCRETION OF MELATONIN IN URINE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NON-ALCOHOLIC FATTY LIVER DISEASE WITH MANIFESTATIONS OF FIBROSIS AND ITS RELATIONSHIP WITH CERTAIN METABOLIC AND IMMUNOLOGICAL INDICATORS.
Topics: Adolescent; Adult; Albuminuria; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; | 2018 |
Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions.
Topics: Aged; Case-Control Studies; Dental Pulp; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assa | 2018 |
Association of melatonin &MTNR1B variants with type 2 diabetes in Gujarat population.
Topics: Adult; Aged; Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Genetic Association Studies; Genet | 2018 |
Melatonin and cryptochrome 2 in metabolic syndrome patients with or without diabetes: a cross-sectional study.
Topics: Adiposity; Adult; Blood Pressure; Cross-Sectional Studies; Cryptochromes; Diabetes Mellitus, Type 2; | 2018 |
[Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats].
Topics: Animals; Antioxidants; Bone Density; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2017 |
Type 2 diabetes-associated variants of the MT
Topics: Antioxidants; beta-Arrestin 2; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated MAP Kinases | 2018 |
XFEL structures of the human MT
Topics: Crystallization; Diabetes Mellitus, Type 2; Electrons; Humans; Indenes; Lasers; Ligands; Melatonin; | 2019 |
[In-depth analysis of the relationship between the MT
Topics: Animals; beta-Arrestins; Circadian Rhythm; Computational Biology; Diabetes Mellitus, Type 2; Drug Ev | 2019 |
Melatonin secretion and the incidence of type 2 diabetes.
Topics: Aged; Case-Control Studies; Cohort Studies; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; I | 2013 |
Low melatonin secretion is a risk factor for type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Melatonin; Risk Factors | 2013 |
Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 2013 |
Melatonin level and risk for type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Melatonin | 2013 |
Melatonin level and risk for type 2 diabetes--in reply.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Melatonin | 2013 |
[Melatonin secretion is associated with diabetes risk].
Topics: Case-Control Studies; Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Humans; Melatonin; Prospe | 2013 |
Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats.
Topics: Animals; Chromium; Diabetes Mellitus, Type 2; Diet, High-Fat; Humans; Insulin; Magnesium; Male; Mela | 2014 |
Antioxidant effect of immediate- versus sustained-release melatonin in type 2 diabetes mellitus and healthy controls.
Topics: Antioxidants; Case-Control Studies; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Erythroc | 2016 |
Activity of the glutathione antioxidant system and NADPH-generating enzymes in blood serum of rats with type 2 diabetes mellitus after administration of melatonin-correcting drugs.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Enzyme Activation; Glucosephosphate Dehydrogenase; | 2014 |
Urinary 6-sulfatoxymelatonin level in diabetic retinopathy patients with type 2 diabetes.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Hu | 2014 |
Melatonin receptors in diabetes: a potential new therapeutical target?
Topics: Animals; Diabetes Mellitus, Type 2; Genetic Variation; Humans; Insulin; Insulin-Secreting Cells; Mam | 2014 |
Activation of Melatonin Signaling Promotes β-Cell Survival and Function.
Topics: Animals; Cell Line, Tumor; Cell Survival; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells | 2015 |
Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Male | 2015 |
Melatonin increases intracellular calcium in the liver, muscle, white adipose tissues and pancreas of diabetic obese rats.
Topics: Adipose Tissue, White; Animals; Calcium; Diabetes Mellitus, Type 2; Humans; Insulin; Liver; Male; Me | 2015 |
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genotype; Glucose Tolerance Test; Humans; M | 2015 |
Melatonin and L-carnitin improves endothelial disfunction and oxidative stress in Type 2 diabetic rats.
Topics: Animals; Antioxidants; Carnitine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2016 |
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.
Topics: Adult; Alleles; Blood Glucose; Circadian Rhythm; Cross-Sectional Studies; Diabetes Mellitus, Type 2; | 2016 |
Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated | 2016 |
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
Topics: Aconitate Hydratase; Adult; Aged; alpha-Tocopherol; Antioxidants; Citric Acid; Diabetes Mellitus, Ty | 2015 |
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes.
Topics: Animals; Cyclic AMP; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glucose; Heterozy | 2016 |
Risk Factors: Melatonin signalling implicated in the risk of T2DM.
Topics: Diabetes Mellitus, Type 2; Humans; Melatonin; Risk Factors | 2016 |
Melatonin suppresses autophagy in type 2 diabetic osteoporosis.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; MAP Ki | 2016 |
A Wake-up Call for Type 2 Diabetes?
Topics: Animals; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genetic Variation; Humans; In | 2016 |
Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus.
Topics: Aluminum Oxide; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Ani | 2016 |
Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C
Topics: Animals; Antioxidants; Cell Line; Cell Respiration; Diabetes Mellitus, Type 2; Electron Transport; M | 2017 |
Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Circadian Rhythm; Creatinine; Diabetes Mellitus, Type 2; Diabetic Retino | 2017 |
Melatonin signalling and type 2 diabetes risk: too little, too much or just right?
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Male; Melatonin; Middle Aged; Sedentary Behavior; | 2017 |
Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supp | 2009 |
Pineal melatonin synthesis is decreased in type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Animals, Genetically Modified; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regu | 2009 |
Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats.
Topics: Animals; Blood Glucose; Body Weight; Chromatography, High Pressure Liquid; Circadian Rhythm; Diabete | 2010 |
Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gluca | 2010 |
No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type | 2011 |
Recognition and assessment of shift work disorder.
Topics: Animals; Biological Clocks; Circadian Rhythm; Diabetes Mellitus, Type 2; Energy Metabolism; Hormones | 2011 |
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified | 2012 |
Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2012 |
Daily rhythms of plasma melatonin, but not plasma leptin or leptin mRNA, vary between lean, obese and type 2 diabetic men.
Topics: Analysis of Variance; Circadian Rhythm; Diabetes Mellitus, Type 2; DNA Primers; Gene Expression Prof | 2012 |
Therapeutic efficacy of melatonin in reducing retinal damage in an experimental model of early type 2 diabetes in rats.
Topics: Animals; Catalase; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Electroretinography; Glucose; Im | 2013 |
The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts.
Topics: Antioxidants; Catalase; Diabetes Mellitus, Type 2; Fibroblasts; Glutathione; Humans; Melatonin; Supe | 2003 |
Relationship between salivary melatonin levels and periodontal status in diabetic patients.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Interleukin-2; Male; Melatonin | 2003 |
Orally administered tryptophan and experimental type 2 diabetes.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus | 2004 |
Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Diab | 2005 |
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; In | 2006 |
Melatonin and type 2 diabetes - a possible link?
Topics: Adult; Aged; Base Sequence; Case-Control Studies; Diabetes Mellitus, Type 2; DNA Primers; DNA-Bindin | 2007 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleot | 2008 |
Can "resetting" hormonal rhythms treat illness?
Topics: Animals; Bromocriptine; Circadian Rhythm; Clinical Trials, Phase III as Topic; Darkness; Diabetes Me | 1995 |
GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity.
Topics: Diabetes Mellitus, Type 2; Fatty Acids, Essential; Glucose; Glucose Transporter Type 4; Humans; Insu | 1999 |
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Topics: Animals; Blood Glucose; Cholesterol; Delta-5 Fatty Acid Desaturase; Diabetes Mellitus, Type 2; Fatty | 2002 |