melatonin has been researched along with Diabetes Mellitus, Type 1 in 17 studies
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Melatonin is neuroprotective against cerebral ischemia-reperfusion injury (CIRI) in non-DM, normoglycemic animals through anti-oxidant effect, anti-inflammation, and anti-apoptosis." | 8.31 | Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects. ( Cheung, RTF; Xu, Q, 2023) |
| " Melatonin is neuroprotective against cerebral ischemia-reperfusion injury (CIRI) in non-DM, normoglycemic animals through anti-oxidant effect, anti-inflammation, and anti-apoptosis." | 4.31 | Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects. ( Cheung, RTF; Xu, Q, 2023) |
| "Hyperglycemia increased retinal oxidation as measured through levels of nitrotyrosine and malondialdehyde." | 3.80 | Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats. ( Bakariş, S; Durdu, H; Ergün, Y; Ganiyusufoğlu, E; Kılınç, M; Ozdemir, G, 2014) |
| "Our long-term goal is to determine the utility of melatonin in prevention of hypertension in type 1 diabetes." | 3.72 | Blood pressure-lowering effect of melatonin in type 1 diabetes. ( Bean, JA; Cavallo, A; Daniels, SR; Dolan, LM; Khoury, JC, 2004) |
| " We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes." | 2.71 | Blood pressure response to melatonin in type 1 diabetes. ( Bean, JA; Cavallo, A; Daniels, SR; Dolan, LM; Khoury, JC, 2004) |
| "In total, 80 adult patients with type 1 diabetes (46% female) were included in a clinical cohort study." | 1.43 | Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag. ( Benhamou, PY; Borel, AL; Gauchez, AS; Lablanche, S; Larcher, S; Pépin, JL, 2016) |
| "Melatonin is an important rhythmic endocrine signal within the circadian system of mammals and modulates insulin secretion and glucose metabolism." | 1.39 | Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice. ( Fischer, C; Korf, HW; Shalabi, A; von Gall, C, 2013) |
| "Melatonin was also effective in restoring the impaired SNP-induced vasorelaxation seen in endothelium-denuded or L-NAME-treated aortic rings from hyperglycemic rats." | 1.33 | Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats. ( Cardinali, DP; Linares, LM; Obaya-Naredo, D; Pinto, JE; Reyes-Toso, CF; Ricci, CR; Rodríguez, RR, 2005) |
| " Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for phenylephrine-induced vasoconstriction were conducted." | 1.32 | Effect of melatonin on vascular reactivity in pancreatectomized rats. ( Arán, M; Cardinali, DP; Linares, LM; Pinto, JE; Reyes-Toso, CF; Ricci, CR; Rodríguez, RR, 2004) |
| " Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for serotonin-induced vasoconstriction were conducted in the presence or absence of 10-5 mol/L melatonin." | 1.31 | Vascular reactivity in diabetic rats: effect of melatonin. ( Albornoz, LE; Cardinali, DP; Damiano, PF; Linares, LM; Reyes-Toso, CF; Rosón, MI, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, Z | 1 |
| Da, W | 1 |
| Tian, Y | 1 |
| Zhao, R | 1 |
| Qiu, S | 1 |
| Wu, Q | 1 |
| Wen, K | 1 |
| Shen, L | 1 |
| Zhou, R | 1 |
| Tao, L | 1 |
| Zhu, Y | 1 |
| Anderson, G | 1 |
| Xu, Q | 1 |
| Cheung, RTF | 1 |
| Shalabi, A | 1 |
| Fischer, C | 1 |
| Korf, HW | 1 |
| von Gall, C | 1 |
| Ozdemir, G | 1 |
| Ergün, Y | 1 |
| Bakariş, S | 1 |
| Kılınç, M | 1 |
| Durdu, H | 1 |
| Ganiyusufoğlu, E | 1 |
| Peschke, E | 3 |
| Bähr, I | 2 |
| Mühlbauer, E | 3 |
| Larcher, S | 1 |
| Gauchez, AS | 1 |
| Lablanche, S | 1 |
| Pépin, JL | 1 |
| Benhamou, PY | 1 |
| Borel, AL | 1 |
| Yu, L | 1 |
| Gong, B | 1 |
| Duan, W | 1 |
| Fan, C | 1 |
| Zhang, J | 1 |
| Li, Z | 1 |
| Xue, X | 1 |
| Xu, Y | 1 |
| Meng, D | 1 |
| Li, B | 1 |
| Zhang, M | 1 |
| Jin, Z | 1 |
| Yu, S | 1 |
| Yang, Y | 1 |
| Wang, H | 1 |
| Hofmann, K | 2 |
| Streck, S | 1 |
| Albrecht, E | 1 |
| Wedekind, D | 2 |
| Pönicke, K | 1 |
| Reyes-Toso, CF | 3 |
| Rosón, MI | 1 |
| Albornoz, LE | 1 |
| Damiano, PF | 1 |
| Linares, LM | 3 |
| Cardinali, DP | 3 |
| Cutando, A | 1 |
| Gómez-Moreno, G | 1 |
| Villalba, J | 1 |
| Ferrera, MJ | 1 |
| Escames, G | 1 |
| Acuña-Castroviejo, D | 1 |
| Cavallo, A | 2 |
| Daniels, SR | 2 |
| Dolan, LM | 2 |
| Khoury, JC | 2 |
| Bean, JA | 2 |
| Ricci, CR | 2 |
| Arán, M | 1 |
| Pinto, JE | 2 |
| Rodríguez, RR | 2 |
| Obaya-Naredo, D | 1 |
| Rittey, CD | 1 |
| Evans, TJ | 1 |
| Gray, CE | 1 |
| Paton, RD | 1 |
| Bojkowski, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Type 1 Diabetes on Sleep Fragmentation[NCT04601519] | 100 participants (Anticipated) | Observational | 2021-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the 'Bystander' Activation of Memory CD8
Topics: Brain-Derived Neurotrophic Factor; Butyrates; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; | 2023 |
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gluc | 2015 |
1 trial available for melatonin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Blood pressure response to melatonin in type 1 diabetes.
Topics: Adolescent; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 1; | 2004 |
14 other studies available for melatonin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Exogenous melatonin prevents type 1 diabetes mellitus-induced bone loss, probably by inhibiting senescence.
Topics: Animals; Diabetes Mellitus, Type 1; Melatonin; Mice; Mice, Inbred C57BL; Receptor, Melatonin, MT1; R | 2022 |
Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Type 1; Hyperglycemia; Infarction, | 2023 |
Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 2013 |
Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopa | 2014 |
Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag.
Topics: Adult; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; Female; Humans; Life Style; Male; | 2016 |
Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cytochromes c; Cytosol; Diabe | 2017 |
The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus).
Topics: Acetylserotonin O-Methyltransferase; Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltr | 2011 |
Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2012 |
Vascular reactivity in diabetic rats: effect of melatonin.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes | 2002 |
Relationship between salivary melatonin levels and periodontal status in diabetic patients.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Interleukin-2; Male; Melatonin | 2003 |
Blood pressure-lowering effect of melatonin in type 1 diabetes.
Topics: Adolescent; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 1; Female; Humans; Hype | 2004 |
Effect of melatonin on vascular reactivity in pancreatectomized rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes | 2004 |
Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats.
Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endotheli | 2005 |
Melatonin state in Mendenhall's syndrome.
Topics: Diabetes Mellitus, Type 1; Humans; Hypoglycemia; Infant, Newborn; Insulin Resistance; Male; Melatoni | 1988 |