melatonin has been researched along with Developmental Disabilities in 31 studies
Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders." | 9.09 | [Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999) |
| "This study explored the safety and efficacy of synthetic melatonin in the treatment of sleep problems in 20 children with developmental disabilities, in a randomized, double-blind, placebo-controlled 6-week trial of melatonin versus placebo." | 9.09 | Melatonin for treatment of sleep disorders in children with developmental disabilities. ( Dodge, NN; Wilson, GA, 2001) |
| "Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities." | 8.91 | Melatonin Treatment in Children with Developmental Disabilities. ( Malow, BA; Schwichtenberg, AJ, 2015) |
| "Serious childhood developmental disabilities are common, and are debilitating for the individual and their family." | 6.42 | Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary. ( Turk, J, 2003) |
| "Melatonin is a pineal hormone known to be important in the regulation of the circadian rhythm, including the sleep-wake cycle." | 6.42 | Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. ( Appleton, RE; Phillips, L, 2004) |
| "We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders." | 5.09 | [Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999) |
| "This study explored the safety and efficacy of synthetic melatonin in the treatment of sleep problems in 20 children with developmental disabilities, in a randomized, double-blind, placebo-controlled 6-week trial of melatonin versus placebo." | 5.09 | Melatonin for treatment of sleep disorders in children with developmental disabilities. ( Dodge, NN; Wilson, GA, 2001) |
| "Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities." | 4.91 | Melatonin Treatment in Children with Developmental Disabilities. ( Malow, BA; Schwichtenberg, AJ, 2015) |
| "Melatonin is widely used for sleep disorders in patients with a range of developmental disorders and neurodisabilities, who also frequently have epilepsy." | 4.89 | Does melatonin affect epileptic seizures? ( Besag, FM; Jain, S, 2013) |
| "Melatonin was associated with earlier waking times than placebo (29." | 2.77 | Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. ( Allport, T; Appleton, R; Choonara, I; Edmond, A; Gamble, C; Gringras, P; Jones, AP; Montgomery, P; Sutcliffe, A; Whitehouse, WP; Wiggs, L; Williamson, PR, 2012) |
| " This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies." | 2.53 | Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions. ( Fu, W; Liu, J; Wang, Y, 2016) |
| "This article reviews circadian rhythm sleep disorders (CRSDs) of children with neurodevelopmental disabilities." | 2.48 | Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. ( Bax, MC; Ipsiroglu, OS; Jan, JE; Owens, JA; Wasdell, MB, 2012) |
| "Serious childhood developmental disabilities are common, and are debilitating for the individual and their family." | 2.42 | Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary. ( Turk, J, 2003) |
| "Melatonin is a pineal hormone known to be important in the regulation of the circadian rhythm, including the sleep-wake cycle." | 2.42 | Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. ( Appleton, RE; Phillips, L, 2004) |
| "Melatonin is a well-known potent endogenous antioxidant pharmacological agent with significant neuroprotective actions." | 1.48 | Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain. ( Ali, T; Kim, MO; Rehman, SU; Shah, FA, 2018) |
| "Melatonin is a promising treatment alternative for serious sleep problems in blind children." | 1.31 | [Melatonin treatment of a blind child with serious sleep disorders]. ( Loge, JH; Ramstad, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 12 (38.71) | 29.6817 |
| 2010's | 16 (51.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, T | 1 |
| Rehman, SU | 1 |
| Shah, FA | 1 |
| Kim, MO | 1 |
| McDaid, C | 1 |
| Parker, A | 1 |
| Scantlebury, A | 1 |
| Fairhurst, C | 1 |
| Dawson, V | 1 |
| Elphick, H | 1 |
| Hewitt, C | 1 |
| Spiers, G | 1 |
| Thomas, M | 1 |
| Beresford, B | 1 |
| Jain, S | 1 |
| Besag, FM | 1 |
| Wang, Y | 1 |
| Fu, W | 1 |
| Liu, J | 1 |
| Schwichtenberg, AJ | 1 |
| Malow, BA | 1 |
| Bock, DE | 1 |
| Roach-Fox, E | 1 |
| Seabrook, JA | 1 |
| Rieder, MJ | 1 |
| Matsui, D | 1 |
| Bruni, O | 1 |
| Alonso-Alconada, D | 1 |
| Besag, F | 1 |
| Biran, V | 1 |
| Braam, W | 2 |
| Cortese, S | 1 |
| Moavero, R | 1 |
| Parisi, P | 1 |
| Smits, M | 1 |
| Van der Heijden, K | 1 |
| Curatolo, P | 1 |
| Jan, JE | 3 |
| Wasdell, MB | 2 |
| Shah, T | 1 |
| Tse, A | 1 |
| Gill, H | 1 |
| Wong, I | 1 |
| Sutcliffe, A | 3 |
| Gringras, P | 3 |
| Appleton, R | 2 |
| Tuleu, C | 1 |
| Smits, MG | 1 |
| Didden, R | 1 |
| Korzilius, H | 1 |
| Van Geijlswijk, IM | 1 |
| Curfs, LM | 1 |
| Muñoz-Hoyos, A | 1 |
| Molina-Carballo, A | 1 |
| Augustin-Morales, M | 1 |
| Contreras-Chova, F | 1 |
| Naranjo-Gómez, A | 1 |
| Justicia-Martínez, F | 1 |
| Uberos, J | 1 |
| Ferber, SG | 1 |
| Als, H | 1 |
| McAnulty, G | 1 |
| Peretz, H | 1 |
| Zisapel, N | 2 |
| Miyamoto, Y | 1 |
| De Leersnyder, H | 2 |
| Laudon, M | 2 |
| Guénolé, F | 1 |
| Baleyte, JM | 1 |
| Bax, MC | 1 |
| Owens, JA | 1 |
| Ipsiroglu, OS | 1 |
| Appleton, RE | 2 |
| Jones, AP | 2 |
| Gamble, C | 2 |
| Williamson, PR | 2 |
| Wiggs, L | 2 |
| Montgomery, P | 2 |
| Barker, C | 1 |
| Lerchl, A | 1 |
| Reiter, RJ | 1 |
| Whitehouse, WP | 1 |
| Choonara, I | 1 |
| Allport, T | 1 |
| Edmond, A | 1 |
| Willey, C | 1 |
| Phillips, B | 1 |
| Turk, J | 1 |
| Phillips, L | 1 |
| Claustrat, B | 1 |
| Munnich, A | 1 |
| Verloes, A | 1 |
| Lancioni, GE | 1 |
| O'Reilly, MF | 1 |
| Basili, G | 1 |
| Ishizaki, A | 1 |
| Sugama, M | 1 |
| Takeuchi, N | 1 |
| Gingold, MK | 1 |
| Jaynes, M | 1 |
| Bodensteiner, JB | 1 |
| Hamilton, D | 1 |
| Seward, N | 1 |
| Fast, DK | 1 |
| Freeman, RD | 1 |
| Dodge, NN | 1 |
| Wilson, GA | 1 |
| Ross, C | 1 |
| Davies, P | 1 |
| Whitehouse, W | 1 |
| Ramstad, K | 2 |
| Loge, JH | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD).[NCT01033565] | Phase 4 | 1 participants (Actual) | Interventional | 2010-03-04 | Terminated (stopped due to Unsuccessful in recruiting appropriate subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assigns numerical score indicating level of improvement compared to baseline. Scale is rated from 1-7: 1= very much improved; 2= much improved; 3= minimally improved; 4= no change; 5= minimally worse; 6= much worse; 7= very much worse. (NCT01033565)
Timeframe: 2 weeks
| Intervention | units on a scale (Number) |
|---|---|
| Natrol | 2 |
12 reviews available for melatonin and Developmental Disabilities
| Article | Year |
|---|---|
Outcome domains and outcome measures used in studies assessing the effectiveness of interventions to manage non-respiratory sleep disturbances in children with neurodisabilities: a systematic review.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous System Depr | 2019 |
Does melatonin affect epileptic seizures?
Topics: Central Nervous System Depressants; Developmental Disabilities; Epilepsy; Humans; Melatonin; Randomi | 2013 |
Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions.
Topics: Adult; Antioxidants; Brain; Cerebral Palsy; Child; Cognition Disorders; Depression; Developmental Di | 2016 |
Melatonin Treatment in Children with Developmental Disabilities.
Topics: Child; Developmental Disabilities; Humans; Hypnotics and Sedatives; Melatonin; Randomized Controlled | 2015 |
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2009 |
[Influences of general anesthetics on the developing mammalian brain].
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Anesthetics, General; Animals; Apoptosis; | 2011 |
Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities.
Topics: Brain; Child; Developmental Disabilities; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhyth | 2012 |
Is melatonin likely to help children with neurodevelopmental disability and chronic severe sleep problems?
Topics: Child, Preschool; Chronic Disease; Developmental Disabilities; Female; Humans; Learning Disabilities | 2002 |
Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.
Topics: Child; Developmental Disabilities; Dietary Supplements; Humans; Melatonin; Sleep Wake Disorders | 2003 |
Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment.
Topics: Antioxidants; Brain; Child; Developmental Disabilities; Humans; Melatonin; Sleep Wake Disorders; Wak | 2004 |
Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps.
Topics: Adolescent; Adult; Behavior Therapy; Child; Chronotherapy; Developmental Disabilities; Female; Human | 1999 |
[Melatonin treatment of sleep disorders in disabled children].
Topics: Administration, Oral; Child; Child, Preschool; Developmental Disabilities; Disabled Children; Humans | 2002 |
8 trials available for melatonin and Developmental Disabilities
| Article | Year |
|---|---|
Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties.
Topics: Antioxidants; Brain; Child; Chromatography, High Pressure Liquid; Developmental Disabilities; Female | 2008 |
Prolonged-release melatonin for children with neurodevelopmental disorders.
Topics: Adolescent; Antioxidants; Child; Child, Preschool; Developmental Disabilities; Drug Delivery Systems | 2011 |
The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).
Topics: Adolescent; Behavior Therapy; Central Nervous System Depressants; Child; Child, Preschool; Developme | 2012 |
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.
Topics: Adolescent; Central Nervous System Depressants; Central Nervous System Diseases; Child; Child Behavi | 2012 |
[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders].
Topics: Adolescent; Adult; Affective Symptoms; Child; Child, Preschool; Circadian Rhythm; Developmental Disa | 1999 |
Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Over Studies; Delayed-Action Preparations; Develop | 2000 |
Melatonin for treatment of sleep disorders in children with developmental disabilities.
Topics: Antioxidants; Child; Child, Preschool; Developmental Disabilities; Double-Blind Method; Humans; Infa | 2001 |
Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study.
Topics: Adolescent; Child; Child, Preschool; Developmental Disabilities; Dose-Response Relationship, Drug; E | 2002 |
11 other studies available for melatonin and Developmental Disabilities
| Article | Year |
|---|---|
Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain.
Topics: Animals; Animals, Newborn; Antioxidants; Calcium-Binding Proteins; Cell Line, Transformed; Central N | 2018 |
Sleep-promoting medications in children: physician prescribing habits in Southwestern Ontario, Canada.
Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Cross-Section | 2016 |
Immediate and prolonged-release melatonin in children with neurodevelopmental disabilities. Author reply to Prof. Zisapel.
Topics: Child; Developmental Disabilities; Disabled Persons; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2017 |
Melatonin--an orphan drug.
Topics: Child; Child, Preschool; Developmental Disabilities; Humans; Melatonin; Orphan Drug Production | 2008 |
Psychosocial dwarfism: psychopathological aspects and putative neuroendocrine markers.
Topics: Adolescent; Adrenocorticotropic Hormone; Analysis of Variance; beta-Endorphin; Chi-Square Distributi | 2011 |
Melatonin and mental capacities in newborn infants.
Topics: Analysis of Variance; Autonomic Nervous System; Child Development; Cognition Disorders; Developmenta | 2011 |
Effects of melatonin should be studied separately in each neurodevelopmental disorder and with specific sleep diagnoses.
Topics: Antioxidants; Developmental Disabilities; Female; Humans; Male; Melatonin; Mental Disorders; Sleep W | 2012 |
Treatment of sleep disorders with melatonin.
Topics: Central Nervous System Diseases; Developmental Disabilities; Female; Humans; Male; Melatonin; Sleep; | 2012 |
Circadian rhythm disorder in a rare disease: Smith-Magenis syndrome.
Topics: Child; Circadian Rhythm; Developmental Disabilities; Genetic Diseases, Inborn; Humans; Melatonin; Ne | 2006 |
Melatonin to treat fragmented sleep needs study.
Topics: Child; Developmental Disabilities; Humans; Intelligence; Melatonin; Sleep Wake Disorders | 1999 |
[Melatonin treatment of a blind child with serious sleep disorders].
Topics: Blindness; Child, Preschool; Chronic Disease; Developmental Disabilities; Humans; Male; Melatonin; P | 2002 |