melatonin and Depressive Disorder studies

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research Excerpts

Excerpt	Relevance	Reference
"To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)."	9.11	Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005)
"The authors' goal was to examine the hypnotic effects of slow-release melatonin during the initial 4 weeks of treatment with fluoxetine in 19 patients with major depressive disorder."	9.08	Melatonin for the treatment of sleep disturbances in major depressive disorder. ( Dolberg, OT; Grunhaus, L; Hirschmann, S, 1998)
"Disrupted circadian rhythm of melatonin secretion in depression shows a relationship with the exacerbation of inflammatory processes."	7.83	Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. ( Araszkiewicz, A; Just, MJ; Ogłodek, EA; Szromek, AR, 2016)
"Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration."	7.76	Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. ( Bartosz, G; Bieńkiewicz, M; Florkowski, A; Gałecka, E; Gałecki, P; Karbownik-Lewińska, M; Lewiński, A; Szemraj, J, 2010)
"Urinary excretion of the principal melatonin metabolite, sulphatoxy melatonin (aMT6s), was assessed both during the day and during the night in 38 female eating disorder patients (anorexia nervosa, n = 17; bulimia nervosa, n = 12; anorexia nervosa + bulimia nervosa, n = 9) and 14 female control subjects."	7.68	Sulphatoxy melatonin: an index of depression in anorexia nervosa and bulimia nervosa. ( Brown, GM; Garfinkel, PE; Kennedy, SH; McVey, G; Parienti, V, 1990)
"Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder."	7.68	Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. ( Birmaher, B; Dahl, RE; Perel, JM; Puig-Antich, J; Ryan, ND; Thomas, CR; Waterman, GS; Williamson, DE, 1992)
"Night-time melatonin secretion was measured in five depressed inpatients with seasonal affective disorder before and after 1-week of morning and evening exposure to bright (3000 lux) and dim (300 lux) light."	7.68	Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results. ( Dardennes, RM; Hakim-Kreis, CM; Musa, CZ; Piketty, ML; Salinas, EO, 1992)
"We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers."	7.68	Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993)
"In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a."	7.67	Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987)
"The 24 hr profiles of melatonin and cortisol in serum, morning levels of ACTH in plasma, and the dexamethasone suppression test (DST) were investigated in 32 acutely ill patients with a RDC diagnosis of major depressive disorder, 24 patients with a history of longlasting unipolar or bipolar major depressive disorder studied in remission, and 33 healthy subjects."	7.67	Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test. ( Beck-Friis, J; Kjellman, BF; Ljunggren, JG; Thorén, M; von Rosen, D; Wetterberg, L, 1985)
"The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes."	7.67	Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."	6.46	Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"in seven male depressed patients with melancholia and five healthy male control subjects."	5.27	Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986)
"To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)."	5.11	Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005)
"The authors' goal was to examine the hypnotic effects of slow-release melatonin during the initial 4 weeks of treatment with fluoxetine in 19 patients with major depressive disorder."	5.08	Melatonin for the treatment of sleep disturbances in major depressive disorder. ( Dolberg, OT; Grunhaus, L; Hirschmann, S, 1998)
"Depression, peptic ulcers, and sexual dysfunction may be exacerbated by a deficiency of melatonin."	4.76	Disorder of the pineal gland associated with depression, peptic ulcers, and sexual dysfunction. ( Maurizi, CP, 1984)
"Disrupted circadian rhythm of melatonin secretion in depression shows a relationship with the exacerbation of inflammatory processes."	3.83	Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. ( Araszkiewicz, A; Just, MJ; Ogłodek, EA; Szromek, AR, 2016)
" Patients with bipolar disorders had significantly lower levels and later onset of melatonin secretion than those with unipolar depression."	3.79	Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. ( Hermens, DF; Hickie, IB; Ip, TK; Naismith, SL; Robillard, R; Rogers, NL; Scott, EM, 2013)
"To assess urinary 6-sulphatoxymelatonin levels in a large consecutive series of patients with migraine and several comorbidities (chronic fatigue, fibromyalgia, insomnia, anxiety, and depression) as compared with controls."	3.76	Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. ( Cipolla-Neto, J; de Souza Vieira, DS; Lin, J; Masruha, MR; Minett, TS; Peres, MF; Vilanova, LC; Zukerman, E, 2010)
"Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration."	3.76	Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. ( Bartosz, G; Bieńkiewicz, M; Florkowski, A; Gałecka, E; Gałecki, P; Karbownik-Lewińska, M; Lewiński, A; Szemraj, J, 2010)
"(1) When an antidepressant is considered a necessary addition to psychological support in treating patients with depression, the first-line drug is a tricyclic such as clomipramine or a selective serotonin reuptake inhibitor (SSRI) such as paroxetine; (2) Agomelatine, a melatonin receptor agonist, is approved in the European Union for the treatment of depression; (3) Available evaluation does not include any clinical trials designed to compare the efficacy of agomelatine with that of a tricyclic or a selective serotonin reuptake inhibitor."	3.75	Agomelatine: new drug. Adverse effects and no proven efficacy. ( , 2009)
"In multiple sclerosis (MS), several neuroimmunomodulatory effectors are known, including melatonin."	3.72	The influence of immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis. ( Faustmann, PM; Haase, CG; Tinnefeld, M, 2004)
"We studied mood disorders and urinary melatonin excretion in 382 postmenopausal women."	3.71	Depression and endogenous melatonin in postmenopausal women. ( Assmus, JD; Elliott, JA; Klauber, MR; Kripke, DF; Langer, RD; Rex, KM; Tuunainen, A, 2002)
"Night-time melatonin secretion was measured in five depressed inpatients with seasonal affective disorder before and after 1-week of morning and evening exposure to bright (3000 lux) and dim (300 lux) light."	3.68	Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results. ( Dardennes, RM; Hakim-Kreis, CM; Musa, CZ; Piketty, ML; Salinas, EO, 1992)
"Urinary excretion of the principal melatonin metabolite, sulphatoxy melatonin (aMT6s), was assessed both during the day and during the night in 38 female eating disorder patients (anorexia nervosa, n = 17; bulimia nervosa, n = 12; anorexia nervosa + bulimia nervosa, n = 9) and 14 female control subjects."	3.68	Sulphatoxy melatonin: an index of depression in anorexia nervosa and bulimia nervosa. ( Brown, GM; Garfinkel, PE; Kennedy, SH; McVey, G; Parienti, V, 1990)
"Nocturnal melatonin suppression to 500 lux light was studied during an acute episode of illness in 8 patients with bipolar disorder, 7 patients with unipolar depression, and 15 age-, sex-, and season-matched normal controls."	3.68	Melatonin suppression in bipolar and unipolar mood disorders. ( Berga, SL; Berkowitz, AL; Clark, CM; Gillin, JC; Kripke, DF; Lam, RW, 1990)
"Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder."	3.68	Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. ( Birmaher, B; Dahl, RE; Perel, JM; Puig-Antich, J; Ryan, ND; Thomas, CR; Waterman, GS; Williamson, DE, 1992)
"We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers."	3.68	Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993)
"Disturbances were studied in the nocturnal circadian pattern of serum melatonin and plasma cortisol levels in 33 female patients with an eating disorder (anorexia nervosa, n = 11; bulimia nervosa, n = 12; or both, n = 10) and in ten female control subjects of comparable age."	3.67	Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. ( Brown, GM; Costa, D; Garfinkel, PE; Kennedy, SH; Parienti, V, 1989)
"The 24 hr profiles of melatonin and cortisol in serum, morning levels of ACTH in plasma, and the dexamethasone suppression test (DST) were investigated in 32 acutely ill patients with a RDC diagnosis of major depressive disorder, 24 patients with a history of longlasting unipolar or bipolar major depressive disorder studied in remission, and 33 healthy subjects."	3.67	Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test. ( Beck-Friis, J; Kjellman, BF; Ljunggren, JG; Thorén, M; von Rosen, D; Wetterberg, L, 1985)
"The authors took a series of 20 serum samples over a 24-hr period for measurement of melatonin in four men and six women with Major Depressive Disorder (DSM-III), at baseline (depressed) and after 4 weeks on imipramine (150-200 mg/day) after achieving clinical remission."	3.67	Effect of imipramine on the circadian rhythm of plasma melatonin in unipolar depression. ( Hariharasubramanian, N; Isaac, I; Nair, NP; Pilapil, C; Quirion, R, 1986)
"In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a."	3.67	Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987)
"The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes."	3.67	Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986)
"Melatonin suppression was calculated by comparing placebo and citalopram light exposure conditions to a dim light baseline."	2.87	The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose. ( Cain, SW; Mansfield, DR; McGlashan, EM; Nandam, LS; Rajaratnam, SMW; Vidafar, P, 2018)
" Melatonin at this dosage (5 mg/day) or at these two times is therefore not a potential alternative treatment for SAD; light remains the therapy of choice."	2.67	Morning or night-time melatonin is ineffective in seasonal affective disorder. ( Aldhous, M; Arendt, J; Gisin, B; Graw, P; Kräuchi, K; Pöldinger, W; Wirz-Justice, A, 1990)
"Delayed sleep phase disorder (DSPD) - a circadian rhythm sleep disorder - is most commonly seen in adolescents."	2.49	Circadian rhythm disorders among adolescents: assessment and treatment options. ( Armstrong, SM; Bartlett, DJ; Biggs, SN, 2013)
"Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs."	2.47	Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? ( Brown, GM; Brzezinski, A; Cardinali, DP; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2011)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."	2.46	Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Bright light therapy is used to treat seasonal affective disorders."	2.46	Circadian rhythms and depression. ( Barriball, E; Boyce, P, 2010)
"Ramelteon is a novel MT(1) and MT(2) melatonergic agonist that has specific effects on melatonin receptors in the SCN and is effective in promoting sleep in experimental animals such as cats and monkeys."	2.45	Melatonin and melatonergic drugs on sleep: possible mechanisms of action. ( Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trahkt, I, 2009)
"Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear."	2.40	Guidelines for prescribing melatonin. ( Avery, D; Landis, C; Lenz, M, 1998)
"Furthermore, the response to sleep deprivation has important research implications."	2.37	Clinical and biological correlates of sleep deprivation in depression. ( Brown, P; Joffe, RT, 1984)
"Treatment with melatonin also prevented LPS-induced increase in lipid peroxidation and the reduction of glutathione levels in the hippocampus."	1.48	Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice. ( Buss, ZS; Doneda, DL; Ferreira, YS; Fraga-Junior, EB; Lima, E; Lopes, L; Mendonça, CB; Rossi, FL; Stupp, IJV; Taniguti, EH; Vandresen-Filho, S; Ynoue, HN, 2018)
"To explore the dynamics of hemostasis in patients with acute coronary syndrome (ACS) in the combination with anxiety and depressive disorders (ADD) during therapy with valdoxan (agomelatine)."	1.42	[An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders]. ( Petrova, MM; Piliugina, MS; Savchenko, AA; Shimohina, NY, 2015)
"Cognitive-behavioral therapy targeting insomnia can effectively enhance the response to antidepressant medication."	1.37	Sleep interventions for the treatment of depression. ( Howland, RH, 2011)
"Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior."	1.35	Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008)
"Seventy-two elders with complaints of insomnia or depression, and 30 young, healthy adults were assessed for 5-7 days at home."	1.31	Circadian abnormalities in older adults. ( Elliott, JA; Klauber, MR; Kripke, DF; Youngstedt, SD, 2001)
"Melatonin secretion was similar in depressed patients and healthy subjects with no significant differences at any of the time points, thus not confirming earlier studies in which depressed patients were found to have lower melatonin levels than control patients."	1.30	Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep. ( Baghai, T; Becker, U; Demisch, L; Haag, C; Laakmann, G; Riemann, D; Voderholzer, U, 1997)
"The melatonin amplitude was significantly decreased by light, and the melatonin phase position was advanced by morning light and delayed by evening light."	1.29	Melatonin in light treatment of patients with seasonal and nonseasonal depression. ( Kjellman, BF; Mørkrid, L; Thalén, BE; Wetterberg, L, 1995)
"Eight patients with endogenous depression who had received no antidepressant treatment for the previous year were treated with the noradrenaline (NA) uptake inhibitor, desipramine (DMI)."	1.28	Noradrenaline uptake inhibition increases melatonin secretion, a measure of noradrenergic neurotransmission, in depressed patients. ( Checkley, SA; Dawling, S; Palazidou, E; Papadopoulos, A; Ratcliff, H, 1992)
"The melatonin measures were not consistently related to any of the previously reported hypothalamic-pituitary-adrenal cortical axis measures in these subjects."	1.28	Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. ( Hanada, K; Heist, EK; Lesser, IM; McGeoy, SS; Rubin, RT, 1992)
"Melatonin secretion has been suggested as a marker of both circadian and noradrenergic dysfunction in affective disorders."	1.28	Nocturnal melatonin and cortisol secretion in newly admitted psychiatric inpatients. Implications for affective disorders. ( Brown, GM; Goldman, S; Steiner, M, 1990)
" There was no change in alpha MT6s excretion, and thus the previously reported potentiation of the efficacy of tricyclic antidepressants in combination with T3 does not appear to be mediated through an alteration in noradrenergic neurotransmission."	1.28	A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. ( Arendt, J; Bearn, J; Checkley, SA; Franey, C, 1989)
"Melatonin is a major endocrine product of the pineal gland."	1.28	Plasma melatonin levels in affective states. ( Burrows, GD; Judd, FK; Marriott, PM; McIntyre, IM; Norman, TR, 1989)
"Sleep, appetite and weight increase in winter depression and decrease in summer depression."	1.28	Seasonal vulnerability to depression. Implications for etiology and treatment. ( Wehr, TA, 1992)
"Melatonin levels were not lower in females than in males, when melatonin levels were adjusted for body height."	1.27	Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. ( Beck-Friis, J; Kjellman, BF; Ljunggren, JG; von Rosen, D; Wetterberg, L, 1984)
"Melatonin was measured in plasma collected between 8:00 and 8:30 a."	1.27	Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl. ( Cohen, RM; Garrick, NA; Murphy, DL; Sunderland, T; Tamarkin, L, 1986)
"in seven male depressed patients with melancholia and five healthy male control subjects."	1.27	Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986)
"Melatonin secretion was inversely correlated with the depressed mood and reality disturbance factors of the Hamilton Depression Scale."	1.27	Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patients. ( Amsterdam, J; Brown, RP; Caroff, S; Frazer, A; Kocsis, JH; Stokes, P; Winokur, A, 1987)
"in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin."	1.27	Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, JH; Stokes, PE; Winokur, A, 1985)
"Melatonin secretion was significantly increased after three weeks of treatment in depressed patients."	1.27	The effect of desipramine upon melatonin and cortisol secretion in depressed and normal subjects. ( Arendt, J; Checkley, SA; Corn, T; English, J; Franey, C; Mezey, G; Thompson, C, 1985)
"Pathophysiological markers of melancholia are being developed in four major areas: 1) neuroendocrine; 2) sleep; 3) psychomotor and 4) biochemical."	1.26	Biological markers of melancholia and reclassification of depressive disorders. ( Greden, JF, 1982)
" An inverse correlation between plasma levels of DMI and plasma levels of melatonin-like immunoreactivity was found in the group of clinical responders to the chronic administration of the drug."	1.26	An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives. ( Halbreich, U; Klein, DF; Quitkin, FM; Stewart, J; Weinberg, U; Weitzman, ED, 1981)

Research

Studies (175)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Headache Diary Compliance Rate

Timeframe	Studies, this research(%)	All Research%
pre-1990	64 (36.57)	18.7374
1990's	52 (29.71)	18.2507
2000's	22 (12.57)	29.6817
2010's	36 (20.57)	24.3611
2020's	1 (0.57)	2.80

Authors	Studies
Zlotos, DP	1
Jockers, R	1
Cecon, E	1
Rivara, S	2
Witt-Enderby, PA	1
Borisova, AB	1
Veltishchev, DY	1
Lisitsyna, TA	1
Reshetnyak, TM	1
Seravina, OF	1
Kovalevskaya, OB	1
Cheldieva, FA	1
Abramkin, AA	1
Bokhan, NA	1
Roshchina, OV	1
Simutkin, GG	1
Levchuk, LA	1
Ivanova, SA	1
Mendoza, J	1
Franklin, M	1
Hlavacova, N	1
Li, Y	1
Bermudez, I	1
Csanova, A	1
Sanchez, C	1
Jezova, D	1
Taniguti, EH	1
Ferreira, YS	1
Stupp, IJV	1
Fraga-Junior, EB	1
Mendonça, CB	1
Rossi, FL	1
Ynoue, HN	1
Doneda, DL	1
Lopes, L	1
Lima, E	1
Buss, ZS	1
Vandresen-Filho, S	1
Satyanarayanan, SK	1
Su, H	1
Lin, YW	1
Su, KP	1
McGlashan, EM	1
Nandam, LS	1
Vidafar, P	1
Mansfield, DR	1
Rajaratnam, SMW	1
Cain, SW	1
Robillard, R	2
Carpenter, JS	1
Rogers, NL	3
Fares, S	1
Grierson, AB	1
Hermens, DF	3
Naismith, SL	3
Mullin, SJ	1
Feilds, KL	1
Glozier, N	1
Scott, EM	2
Hickie, IB	3
Kuppili, PP	1
Nebhinani, N	1
Gupta, T	1
Suthar, N	1
Norman, TR	3
Ip, TK	2
Schmelting, B	1
Corbach-Söhle, S	1
Kohlhause, S	1
Schlumbohm, C	1
Flügge, G	1
Fuchs, E	1
Bartlett, DJ	1
Biggs, SN	1
Armstrong, SM	1
Aubrecht, TG	1
Weil, ZM	2
Nelson, RJ	2
Shimohina, NY	1
Petrova, MM	1
Savchenko, AA	1
Piliugina, MS	1
Zurawek, D	1
Kusmider, M	1
Faron-Gorecka, A	1
Gruca, P	1
Pabian, P	1
Kolasa, M	1
Solich, J	1
Szafran-Pilch, K	1
Papp, M	1
Dziedzicka-Wasylewska, M	1
Yuan, M	1
Liu, LJ	1
Xu, LZ	1
Guo, TY	1
Yue, XD	1
Li, SX	1
Ogłodek, EA	1
Just, MJ	1
Szromek, AR	1
Araszkiewicz, A	1
Radeljak, S	1
Zarković-Palijan, T	1
Kovacević, D	1
Kovac, M	1
Cam, E	1
Yulug, B	1
Cengiz, N	1
Poelkin, E	1
Isýk, D	1
Bakar, M	1
Ozan, E	1
Kilic, E	1
Azorin, JM	1
Kaladjian, A	1
Srinivasan, V	5
Pandi-Perumal, SR	4
Trahkt, I	1
Spence, DW	3
Poeggeler, B	1
Hardeland, R	1
Cardinali, DP	4
Masruha, MR	1
Lin, J	1
de Souza Vieira, DS	1
Minett, TS	1
Cipolla-Neto, J	1
Zukerman, E	1
Vilanova, LC	1
Peres, MF	1
Lewy, AJ	5
Carter, KA	1
Lettieri, CJ	1
Peńa, JM	1
Gałecki, P	1
Szemraj, J	1
Bartosz, G	1
Bieńkiewicz, M	1
Gałecka, E	1
Florkowski, A	1
Lewiński, A	1
Karbownik-Lewińska, M	1
Boyce, P	1
Barriball, E	1
Singh, J	1
Brown, GM	12
Howland, RH	1
Sumegi, A	1
Somoskovi, C	1
Brown, MA	1
Quan, SF	1
Eichling, PS	1
Brzezinski, A	1
Spadoni, G	1
Bedini, A	1
Mor, M	1
Hidalgo, MP	1
Caumo, W	1
Dantas, G	1
Franco, DG	1
Torres, IL	1
Pezzi, J	1
Elisabetsky, E	1
Detanico, BC	1
Piato, Â	1
Markus, RP	1
Arushanian, ÉB	2
Chancellor, D	1
Posadas, ES	1
Meliska, CJ	2
Martinez, LF	2
Sorenson, DL	2
Lopez, AM	2
Nowakowski, S	2
Hauger, R	1
Parry, BL	3
Niederhofer, H	1
von Klitzing, K	1
Bolitho, S	1
Scott, E	1
Haridas, S	1
Kumar, M	1
Manda, K	1
Zakaria, R	1
Othman, Z	1
Lauterbach, EC	1
Acuña-Castroviejo, D	1
Paparrigopoulos, T	1
Varma, A	1
Kaul, RK	1
Varma, P	1
Kalra, V	1
Malhotra, V	1
Haase, CG	1
Tinnefeld, M	1
Faustmann, PM	1
Goto, K	1
Mocaër, E	1
Delalleau, B	1
Boyer, PA	1
de Bodinat, C	1
Lu, WZ	1
Gwee, KA	1
Moochhalla, S	1
Ho, KY	1
Dagan, Y	1
Ayalon, L	1
Wirz-Justice, A	2
Hotchkiss, AK	1
Gatien, ML	1
Pieke-Dahl, S	1
Smits, M	1
Spence, W	1
Lowe, AD	1
Kayumov, L	1
Parry, B	1
Bordet, R	1
Hauger, RL	1
Elliott, JA	3
Zeng, Q	1
Wang, S	1
Lim, G	1
Yang, L	1
Mao, J	2
Sung, B	1
Chang, Y	1
Lim, JA	1
Guo, G	1
Joffe, RT	1
Brown, P	1
Linkowski, P	2
Mendlewicz, J	2
Wetterberg, L	15
Maurizi, CP	3
Beck-Friis, J	5
Kjellman, BF	7
Ljunggren, JG	5
von Rosen, D	3
Claustrat, B	2
Chazot, G	2
Brun, J	2
Jordan, D	1
Sassolas, G	1
Nair, NP	4
Hariharasubramanian, N	3
Pilapil, C	2
Greden, JF	1
Halbreich, U	2
Weinberg, U	2
Stewart, J	1
Klein, DF	1
Weitzman, ED	1
Quitkin, FM	3
Branchey, L	1
Branchey, M	1
Ahmed, SK	1
Kin, NM	1
West, TE	1
Kennedy, SH	7
Leibenluft, E	1
Fiero, PL	1
Rubinow, DR	1
Sandyk, R	3
Awerbuch, GI	1
Ravindran, AV	1
Bialik, RJ	1
Lapierre, YD	1
Kay, RW	1
Lack, L	1
Wright, H	1
Murphy, DG	2
Murphy, DM	2
Abbas, M	2
Palazidou, E	3
Binnie, C	1
Arendt, J	9
Campos Costa, D	1
Checkley, SA	7
Marks, M	1
Winton, F	2
Franey, C	5
Thalén, BE	2
Mørkrid, L	2
Stoll, S	1
Müller, WE	1
Kutcher, SP	1
Ralevski, E	1
Shafii, M	1
MacMillan, DR	1
Key, MP	1
Derrick, AM	1
Kaufman, N	1
Nahinsky, ID	1
deVries, MW	1
Peeters, FP	1
Sekula, LK	1
Lucke, JF	1
Heist, EK	2
Czambel, RK	1
Rubin, RT	2
Little, KY	1
Ranc, J	1
Gilmore, J	1
Patel, A	1
Clark, TB	1
Kellner, M	1
Yassouridis, A	1
Manz, B	1
Steiger, A	1
Holsboer, F	1
Wiedemann, K	1
Singer, W	1
Joffe, R	1
Voderholzer, U	1
Laakmann, G	1
Becker, U	1
Haag, C	1
Baghai, T	1
Riemann, D	1
Demisch, L	2
Avery, D	1
Lenz, M	1
Landis, C	1
Panzer, A	1
Dolberg, OT	1
Hirschmann, S	1
Grunhaus, L	1
Wahlund, B	2
Grahn, H	2
Sääf, J	2
Manber, R	1
Armitage, R	1
Nurnberger, JI	1
Adkins, S	1
Lahiri, DK	1
Mayeda, A	1
Hu, K	1
Lewy, A	1
Miller, A	1
Bowman, ES	1
Miller, MJ	1
Rau, L	1
Smiley, C	1
Davis-Singh, D	1
Krahn, LE	1
Gleber, E	1
Rummans, TA	1
Pileggi, TS	1
Lucas, DL	1
Li, H	1
Youngstedt, SD	1
Kripke, DF	4
Klauber, MR	2
Tuunainen, A	1
Assmus, JD	1
Rex, KM	1
Langer, RD	1
Dann, LC	1
Wehr, TA	5
Papadopoulos, A	1
Ratcliff, H	1
Dawling, S	1
Darcourt, G	3
Souêtre, E	4
Pringuey, D	3
Robert, P	2
Feuillade, P	1
Belugou, JL	3
Modai, I	2
Malmgren, R	2
Eneroth, P	1
Valevski, A	1
Asberg, M	2
Salinas, EO	1
Hakim-Kreis, CM	1
Piketty, ML	1
Dardennes, RM	1
Musa, CZ	1
Aperia, B	2
Gorelick, DA	1
Gwirtzman, HE	1
McGuire, MT	1
Serafetinides, EA	1
Yuwiler, A	1
Rao, ML	2
Müller-Oerlinghausen, B	2
Mackert, A	2
Strebel, B	2
Stieglitz, RD	2
Volz, HP	2
Waterman, GS	1
Ryan, ND	1
Perel, JM	1
Dahl, RE	1
Birmaher, B	1
Williamson, DE	1
Thomas, CR	1
Puig-Antich, J	1
Monteleone, P	1
Maj, M	1
Fusco, M	1
Kemali, D	1
Reiter, RJ	1
McGeoy, SS	1
Hanada, K	1
Lesser, IM	1
McVey, G	3
Garfinkel, PE	3
Robinson, S	1
Rosca, P	1
Durst, R	1
Shai, U	1
Ghinea, C	1
Schmidt, U	1
Nir, I	2
Steiner, M	2
Goldman, S	1
Graw, P	1
Kräuchi, K	1
Gisin, B	1
Aldhous, M	1
Pöldinger, W	1
Dietzel, M	1
Lam, RW	1
Berkowitz, AL	1
Berga, SL	2
Clark, CM	1
Gillin, JC	2
Sack, RL	4
White, DM	2
Singer, CM	2
Fireman, MJ	1
Vandiver, R	1
Ohashi, M	1
Nawata, H	1
Parienti, V	2
von Knorring, L	2
Almay, BG	2
Häggendal, J	1
Johansson, F	1
Oreland, L	1
Bearn, J	1
Stewart, JW	3
Blehar, MC	1
Rosenthal, NE	5
Hartmann, W	1
Kluge, H	1
Tighe, S	1
Cummings, MA	1
Cummings, KL	1
Haviland, MG	1
Golshan, S	1
McIntyre, IM	2
Judd, FK	2
Marriott, PM	1
Burrows, GD	2
Terman, M	3
Schlager, D	1
Fairhurst, S	1
Perlman, B	1
Salvati, E	3
Krebs, B	2
Candito, M	1
Ardisson, JL	1
Corn, T	2
Huson, LW	1
Golden, RN	2
Potter, WZ	2
Werstiuk, ES	1
Seggie, J	1
Kasper, S	1
Costa, D	1
Thorén, M	1
Murphy, DL	1
Tamarkin, L	2
Sunderland, T	1
Garrick, NA	1
Cohen, RM	1
Beving, H	1
Markey, SP	1
Risby, ED	1
Rudorfer, MV	1
Cowdry, RW	1
Gerbaldo, H	1
Demisch, K	1
Jarrett, DB	1
Miewald, JM	1
Kupfer, DJ	1
Thompson, C	2
Cavallo, A	2
Jacobsen, FM	3
Sack, DA	3
James, SP	1
Miles, A	1
Philbrick, DR	1
Terman, JS	2
Cooper, TB	1
Lo, ES	1
Gorman, JM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
"Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316]	Phase 2	31 participants (Actual)	Interventional	2015-05-31	Completed
Melatonin for Adolescent Migraine Prevention Study (The MAP Study).[NCT03150797]	Phase 2	72 participants (Actual)	Interventional	2017-08-02	Terminated (stopped due to Insufficient Fund)
Bright Light Therapy Efficacy for Depressive Symptoms Following Cardiac Surgery or Acute Coronary Syndrome: Pilot Trial[NCT02621567]	Phase 4	15 participants (Actual)	Interventional	2016-01-31	Completed
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478]	Phase 2	3 participants (Actual)	Interventional	2009-01-31	Terminated
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]	Phase 4	25 participants (Actual)	Interventional	2008-01-31	Completed
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657]	Phase 4	120 participants (Actual)	Interventional	2017-05-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study

Medication Adherence as Measured by Number of Openings Per Participant

Intervention	Participants (Count of Participants)
Melatonin	11
Placebo	10

eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"

Number of Migraine/Migrainous Days Per 28 Day Period

Intervention	Mean Number of Openings (Mean)
Melatonin	39
Placebo	60

Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment

Number of Minutes to Sleep Onset

Intervention	days (Mean)
Melatonin	3.6
Placebo	4.9

Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks

Change in Mean Migraine/Migrainous Days From Weeks 5-8 of Single-blind Treatment Phase to Weeks 5-8 of Randomized Treatment Phase for Each Group.

Intervention	minutes (Mean)
Melatonin	15.2
Placebo	17.2

Change in mean migraine/migrainous days from weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase for each group. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase.

Mean CASQ (Cleveland Adolescent Sleepiness Questionnaire) Score in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Intervention	days (Median)
Melatonin 3mg	2
Melatonin 6mg	-1
Placebo Oral Capsule	0

Mean CASQ score in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. The CASQ is a 16-question instrument that uses Likert-like responses and has a score range from 16-80; higher scores indicate greater sleepiness (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 3 mg vs. Placebo.

Intervention	points (Mean)
Melatonin 3mg	33
Melatonin 6mg	36
Placebo Oral Capsule	28

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 3 mg vs. placebo. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 6 mg vs. Melatonin 3 mg.

Intervention	days (Median)
Melatonin 3mg	2
Melatonin 6mg	2
Placebo Oral Capsule	2

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. melatonin 3 mg. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin 6 mg vs. Placebo.

Intervention	days (Median)
Melatonin 3mg	2
Melatonin 6mg	2
Placebo Oral Capsule	2

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. placebo. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Participants vs. Placebo.

Intervention	days (Median)
Melatonin 3mg	2
Melatonin 6mg	2
Placebo Oral Capsule	2

Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin treated participants vs. placebo. (Ultimately, as the data were not normally distributed, medians were more appropriate). (NCT03150797)
Timeframe: weeks 5-8 of randomized treatment phase

Number of Days Acute Medication is Used in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Intervention	days (Median)
Melatonin 3mg	2
Melatonin 6mg	2
Placebo Oral Capsule	2

Number of days acute medication is used in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to the number of days that medication for the acute treatment of headache was used during the time frame. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Number of Headache Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Group vs. Placebo, and in Each of the Three Pair-wise Group Comparisons.

Intervention	days (Median)
Melatonin 3mg	5
Melatonin 6mg	3
Placebo Oral Capsule	3

Number of headache days in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to number of headache days during the time period--regardless of whether they were migraine or not. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.

Change in Abdominal Fat (DEXA).

Intervention	days (Median)
Melatonin 3mg	8
Melatonin 6mg	4
Placebo Oral Capsule	5

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Intervention	g (Mean)
Ramelteon	3934.86
Placebo (Sugar Pill)	5120.92

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Waist Circumference

Intervention	HOMA score (Mean)
Ramelteon	2.4
Placebo (Sugar Pill)	2.36

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Article	Year
Circadian insights into the biology of depression: Symptoms, treatments and animal models. Behavioural brain research, 2019, 12-30, Volume: 376 Topics: Animals; Biological Clocks; Circadian Rhythm; Depression; Depressive Disorder; Disease Models, Anima	2019
Circadian Rhythm and Melatonin in the Treatment of Depression. Current pharmaceutical design, 2018, Volume: 24, Issue:22 Topics: Circadian Rhythm; Depressive Disorder; Humans; Melatonin	2018
Circadian rhythm disorders among adolescents: assessment and treatment options. The Medical journal of Australia, 2013, Oct-21, Volume: 199, Issue:8 Topics: Adolescent; Anxiety Disorders; Australia; Comorbidity; Cross-Sectional Studies; Depressive Disorder;	2013
Chromotherapy in the regulation of neurohormonal balance in human brain--complementary application in modern psychiatric treatment. Collegium antropologicum, 2008, Volume: 32 Suppl 2 Topics: Color Therapy; Depressive Disorder; Humans; Melatonin; Seasonal Affective Disorder; Serotonin; Sleep	2008
[Depression and circadian rhythm]. L'Encephale, 2009, Volume: 35 Suppl 2 Topics: Biological Clocks; Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Seasonal Affective Diso	2009
Melatonin and melatonergic drugs on sleep: possible mechanisms of action. The International journal of neuroscience, 2009, Volume: 119, Issue:6 Topics: Acetamides; Aging; Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Humans; Hy	2009
Circadian rhythms and depression. Australian family physician, 2010, Volume: 39, Issue:5 Topics: Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Family Practice; Female; Humans; Incid	2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Advances in therapy, 2010, Volume: 27, Issue:11 Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Hum	2010
[Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2010, Volume: 12, Issue:4 Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Drug Synergism	2010
Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jun-01, Volume: 35, Issue:4 Topics: Acetamides; Animals; Benzodiazepines; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Depressi	2011
Melatonin receptor agonists: new options for insomnia and depression treatment. CNS neuroscience & therapeutics, 2011, Volume: 17, Issue:6 Topics: Animals; Depressive Disorder; Depressive Disorder, Major; Drug Design; Humans; Melatonin; Receptors,	2011
[Melatoninergic antidepressant valdoxan]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:7 Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Pineal	2011
Agomelatine in depressive disorders: its novel mechanisms of action. The Journal of neuropsychiatry and clinical neurosciences, 2012,Summer, Volume: 24, Issue:3 Topics: Acetamides; Animals; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Disease Models,	2012
[Melatonin]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8 Topics: Aging; Biomarkers; Breast Neoplasms; Chromatography, High Pressure Liquid; Circadian Rhythm; Depress	2005
[Development of a new antidepressant : agomelatine]. Medecine sciences : M/S, 2005, Volume: 21, Issue:10 Topics: Acetamides; Animals; Circadian Rhythm; Depressive Disorder; Disease Models, Animal; Humans; Hypnotic	2005
Biological rhythm disturbances in mood disorders. International clinical psychopharmacology, 2006, Volume: 21 Suppl 1 Topics: Acetamides; Antidepressive Agents; Biological Clocks; Circadian Rhythm; Clinical Trials as Topic; De	2006
Melatonin in mood disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:3 Topics: Antidepressive Agents; Biomarkers; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Depressi	2006
[The melatonin system, biological rhythms and mood disorders]. L'Encephale, 2006, Volume: 32, Issue:5 Pt 2 Topics: Affect; Circadian Rhythm; Depressive Disorder; Homeostasis; Humans; Hypothalamus; Melatonin; Pineal	2006
Clinical and biological correlates of sleep deprivation in depression. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:6 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Homovanillic Acid; Humans; Hydrocortisone;	1984
[Neuroendocrinology of depressive disorders]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982, Dec-02, Volume: 58, Issue:44 Topics: Adrenocorticotropic Hormone; Depressive Disorder; Dexamethasone; Dextroamphetamine; Growth Hormone;	1982
The relationship between the pineal gland and the pituitary--adrenal axis in health, endocrine and psychiatric conditions. Psychoneuroendocrinology, 1983, Volume: 8, Issue:1 Topics: Adenoma; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Circadian Rhythm; Cushing Syndr	1983
Disorder of the pineal gland associated with depression, peptic ulcers, and sexual dysfunction. Southern medical journal, 1984, Volume: 77, Issue:12 Topics: Biological Clocks; Brain Diseases; Depressive Disorder; Female; Humans; Male; Melatonin; Peptic Ulce	1984
Reversible and selective inhibitors of monoamine oxidase A in the treatment of depressed elderly patients. Acta psychiatrica Scandinavica. Supplementum, 1995, Volume: 386 Topics: Aged; Antidepressive Agents, Tricyclic; Benzamides; Depressive Disorder; Dose-Response Relationship,	1995
Melatonin disturbances in anorexia nervosa and bulimia nervosa. The International journal of eating disorders, 1994, Volume: 16, Issue:3 Topics: Anorexia Nervosa; Bulimia; Circadian Rhythm; Depressive Disorder; Energy Intake; Female; Humans; Hyp	1994
Effects of the menstrual cycle on dependent variables in mood disorder research. Archives of general psychiatry, 1994, Volume: 51, Issue:10 Topics: Adult; beta-Endorphin; Body Temperature; Circadian Rhythm; Depressive Disorder; Female; Growth Hormo	1994
Nocturnal melatonin secretion in multiple sclerosis patients with affective disorders. The International journal of neuroscience, 1993, Volume: 68, Issue:3-4 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Lithium Carbonate; Male; Melaton	1993
[Melatonin. Hormone or wonder drug?]. Medizinische Monatsschrift fur Pharmazeuten, 1996, Volume: 19, Issue:3 Topics: Adult; Aged; Aging; Alzheimer Disease; Animals; Circadian Rhythm; Depressive Disorder; Humans; Melat	1996
Guidelines for prescribing melatonin. Annals of medicine, 1998, Volume: 30, Issue:1 Topics: Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Drug Administration Schedule; Female;	1998
Sex, steroids, and sleep: a review. Sleep, 1999, Aug-01, Volume: 22, Issue:5 Topics: Animals; Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Hyp	1999
[Epiphysis cerebri and depression (review)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1991, Volume: 91, Issue:6 Topics: Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Disease Models, Animal; Human	1991
Psychoneuroendocrinology of depression. Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa, 1989, Volume: 14, Issue:2 Topics: Depressive Disorder; Dexamethasone; Growth Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal	1989
Seasonal affective disorders and phototherapy. Report of a National Institute of Mental Health-sponsored workshop. Archives of general psychiatry, 1989, Volume: 46, Issue:5 Topics: Animals; Depressive Disorder; Humans; Melatonin; National Institute of Mental Health (U.S.); Phototh	1989
[The rhythm of melatonin synthesis in the epiphysis and its control by light]. Psychiatrie, Neurologie, und medizinische Psychologie, 1989, Volume: 41, Issue:4 Topics: Circadian Rhythm; Depressive Disorder; Humans; Light; Melatonin; Pineal Gland	1989
[Season-related forms of depression. II. Modification by phototherapy and biological results]. Der Nervenarzt, 1988, Volume: 59, Issue:4 Topics: Depressive Disorder; Humans; Melatonin; Neurotransmitter Agents; Phototherapy; Seasons; Syndrome	1988
Melatonin and psychiatry. Biological psychiatry, 1988, Feb-15, Volume: 23, Issue:4 Topics: Animals; Antidepressive Agents; Brain; Chronobiology Phenomena; Depressive Disorder; Humans; Melaton	1988
The phase shift hypothesis for bright light's therapeutic mechanism of action: theoretical considerations and experimental evidence. Psychopharmacology bulletin, 1987, Volume: 23, Issue:3 Topics: Depressive Disorder; Humans; Melatonin; Phototherapy; Time Factors	1987
Affective disorders and circadian rhythms. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Affect; Antidepressive Agents; Bipolar Disorder; Body Temperature; Circadian Rhythm; Cues; Depressiv	1986
Light therapy and psychiatry. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 183, Issue:1 Topics: Atenolol; Circadian Rhythm; Depression; Depressive Disorder; Humans; Light; Melatonin; Mental Disord	1986
[Circadian rhythms and depression]. Annales medico-psychologiques, 1985, Volume: 143, Issue:9 Topics: Antidepressive Agents, Tricyclic; Biological Clocks; Body Temperature; Circadian Rhythm; Depressive	1985

Article	Year
The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose. Psychopharmacology, 2018, Volume: 235, Issue:11 Topics: Adult; Antidepressive Agents; Circadian Clocks; Circadian Rhythm; Citalopram; Cross-Over Studies; De	2018
Bright light treatment as mono-therapy of non-seasonal depression for 28 adolescents. International journal of psychiatry in clinical practice, 2012, Volume: 16, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Circadian Rhythm; Cross-Over Studies; Depressive Disorder;	2012
Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Alimentary pharmacology & therapeutics, 2005, Nov-15, Volume: 22, Issue:10 Topics: Adult; Aged; Anxiety; Depressive Disorder; Double-Blind Method; Female; Gastrointestinal Agents; Hum	2005
[Melatonin. Hormone or wonder drug?]. Medizinische Monatsschrift fur Pharmazeuten, 1996, Volume: 19, Issue:3 Topics: Adult; Aged; Aging; Alzheimer Disease; Animals; Circadian Rhythm; Depressive Disorder; Humans; Melat	1996
Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression? Neuroendocrinology, 1997, Volume: 65, Issue:4 Topics: Adult; Corticotropin-Releasing Hormone; Depressive Disorder; Humans; Hydrocortisone; Injections, Int	1997
Melatonin for the treatment of sleep disturbances in major depressive disorder. The American journal of psychiatry, 1998, Volume: 155, Issue:8 Topics: Adult; Aged; Ambulatory Care; Analysis of Variance; Delayed-Action Preparations; Depressive Disorder	1998
Morning or night-time melatonin is ineffective in seasonal affective disorder. Journal of psychiatric research, 1990, Volume: 24, Issue:2 Topics: Adult; Aged; Circadian Rhythm; Combined Modality Therapy; Depressive Disorder; Drug Administration S	1990
Morning vs evening light treatment for winter depression. Evidence that the therapeutic effects of light are mediated by circadian phase shifts. Archives of general psychiatry, 1990, Volume: 47, Issue:4 Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Melatonin; Mi	1990
The influence of phototherapy on serotonin and melatonin in non-seasonal depression. Pharmacopsychiatry, 1990, Volume: 23, Issue:3 Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Phototherapy; Seroton	1990
Plasma melatonin levels in depressed patients before and after treatment with antidepressant medication. Biological psychiatry, 1989, Volume: 25, Issue:1 Topics: Adolescent; Adult; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Female; Fol	1989
Effects of light treatment upon mood and melatonin in patients with seasonal affective disorder. Psychological medicine, 1989, Volume: 19, Issue:3 Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Phototherapy; Psychi	1989
Antidepressants reduce whole-body norepinephrine turnover while enhancing 6-hydroxymelatonin output. Archives of general psychiatry, 1988, Volume: 45, Issue:2 Topics: Adult; Animals; Antidepressive Agents; Bupropion; Depressive Disorder; Desipramine; Female; Humans;	1988
Atenolol in seasonal affective disorder: a test of the melatonin hypothesis. The American journal of psychiatry, 1988, Volume: 145, Issue:1 Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male	1988
Neuroendocrine response to 5-hydroxytryptophan in seasonal affective disorder. Archives of general psychiatry, 1987, Volume: 44, Issue:12 Topics: 5-Hydroxytryptophan; Adult; Blood Pressure; Depressive Disorder; Female; Growth Hormone; Humans; Hyd	1987
Effect of lysine vasopressin in depressed patients on mood and 24-hour rhythm of growth hormone, cortisol, melatonin and prolactin. Psychoneuroendocrinology, 1985, Volume: 10, Issue:3 Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Clinical Trials as Topic; Depressive Disorder; Doub	1985

Article	Year
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. Journal of medicinal chemistry, 2014, Apr-24, Volume: 57, Issue:8 Topics: Animals; Binding Sites; Depressive Disorder; Humans; Ligands; Melatonin; Models, Molecular; Protein	2014
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:3 Topics: Adolescent; Adult; Aged; Alcoholism; Anhedonia; Antiphospholipid Syndrome; Anxiety; Comorbidity; Dep	2022
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats. Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10-03, Volume: 79, Issue:Pt B Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Diseas	2017
Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice. Physiology & behavior, 2018, 05-01, Volume: 188 Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Model	2018
Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders. Translational psychiatry, 2018, 10-09, Volume: 8, Issue:1 Topics: Actigraphy; Adolescent; Adult; Body Temperature; Circadian Rhythm; Depressive Disorder; Female; Huma	2018
Management of a rare case of advanced sleep phase disorder in a patient with persistent depressive disorder. Asian journal of psychiatry, 2019, Volume: 43 Topics: Aged; Central Nervous System Depressants; Cognitive Behavioral Therapy; Depressive Disorder; Disease	2019
Agomelatine, melatonin and depressive disorder. Expert opinion on investigational drugs, 2013, Volume: 22, Issue:4 Topics: Acetamides; Animals; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Human	2013
Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. European psychiatry : the journal of the Association of European Psychiatrists, 2013, Volume: 28, Issue:7 Topics: Adolescent; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Me	2013
Agomelatine in the tree shrew model of depression: effects on stress-induced nocturnal hyperthermia and hormonal status. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:3 Topics: Acetamides; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Body Temperatu	2014
Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses. Behavioural brain research, 2014, Apr-15, Volume: 263 Topics: Anhedonia; Animals; Anxiety; CA1 Region, Hippocampal; Cricetinae; Dendrites; Depressive Disorder; Di	2014
[An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:2 Topics: Acetamides; Acute Coronary Syndrome; Adult; Aged; Anxiety; Central Nervous System Depressants; Depre	2015
Time-dependent miR-16 serum fluctuations together with reciprocal changes in the expression level of miR-16 in mesocortical circuit contribute to stress resilient phenotype in chronic mild stress - An animal model of depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:1 Topics: Anhedonia; Animals; Biomarkers; Chronic Disease; Corticosterone; Depressive Disorder; Dietary Sucros	2016
Effects of environmental stress on the depression-like behaviors and the diurnal rhythm of corticosterone and melatonin in male rats. Sheng li xue bao : [Acta physiologica Sinica], 2016, Jun-25, Volume: 68, Issue:3 Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Depressive Disorde	2016
Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. Pharmacological reports : PR, 2016, Volume: 68, Issue:5 Topics: Adult; Brain; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Female; Humans; Ma	2016
Melatonin: a suitable agent for depression associated with stroke? The Journal of neuropsychiatry and clinical neurosciences, 2008,Fall, Volume: 20, Issue:4 Topics: Animals; Antioxidants; Cerebral Infarction; Depressive Disorder; Humans; Ischemic Attack, Transient;	2008
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache, 2010, Volume: 50, Issue:3 Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul	2010
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache, 2010, Volume: 50, Issue:3 Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul	2010
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache, 2010, Volume: 50, Issue:3 Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul	2010
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache, 2010, Volume: 50, Issue:3 Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul	2010
Agomelatine: new drug. Adverse effects and no proven efficacy. Prescrire international, 2009, Volume: 18, Issue:104 Topics: Acetamides; Animals; Antidepressive Agents; Bias; Carcinogens; Clinical Trials as Topic; Cyclohexano	2009
Depressive disorders may more commonly be related to circadian phase delays rather than advances: time will tell. Sleep medicine, 2010, Volume: 11, Issue:2 Topics: Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Sleep Disorders, Circadian Rhythm	2010
An unusual cause of insomnia following IED-induced traumatic brain injury. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010, Apr-15, Volume: 6, Issue:2 Topics: Adult; Bombs; Brain Injuries; Central Nervous System Depressants; Depressive Disorder; Eye Injuries;	2010
Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. Journal of pineal research, 2010, Volume: 48, Issue:4 Topics: Acetylserotonin O-Methyltransferase; Adult; Chi-Square Distribution; Depressive Disorder; Female; Ge	2010
Sleep interventions for the treatment of depression. Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:1 Topics: Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Central Nervous System Depressants; Co	2011
Circadian rhythm sleep disorder, free-running type in a sighted male with severe depression, anxiety, and agoraphobia. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Feb-15, Volume: 7, Issue:1 Topics: Aged; Agoraphobia; Anxiety Disorders; Combined Modality Therapy; Depressive Disorder; Disease Progre	2011
6‐Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients. Human psychopharmacology, 2011, Volume: 26, Issue:3 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Biomarkers; Depressive Disorder; Female; Humans; Me	2011
The depression market. Nature reviews. Drug discovery, 2011, Oct-31, Volume: 10, Issue:11 Topics: Acetamides; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Drug Discovery; Hu	2011
The relationship of nocturnal melatonin to estradiol and progesterone in depressed and healthy pregnant women. Journal of women's health (2002), 2012, Volume: 21, Issue:6 Topics: Adult; Analysis of Variance; Body Mass Index; California; Circadian Rhythm; Depressive Disorder; Est	2012
Circadian profiles in young people during the early stages of affective disorder. Translational psychiatry, 2012, May-29, Volume: 2 Topics: Adolescent; Adult; Anxiety Disorders; Area Under Curve; Attention; Child; Circadian Rhythm; Depressi	2012
Chronic melatonin administration mitigates behavioral dysfunction induced by γ-irradiation. Hormones and behavior, 2012, Volume: 62, Issue:5 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Depressive Disorder; Drug Administration Schedule; G	2012
Melatonin response to atenolol administration in depression: indication of beta-adrenoceptor dysfunction in a subtype of depression. Acta psychiatrica Scandinavica, 2002, Volume: 106, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Case-Control Studies; Depressive Disorder; Dose-	2002
The effect of antidepressants on serum melatonin levels in endogenous depression. The Journal of the Association of Physicians of India, 2002, Volume: 50 Topics: Adult; Antidepressive Agents; Biomarkers; Case-Control Studies; Chi-Square Distribution; Depressive	2002
The influence of immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis. Neuroimmunomodulation, 2004, Volume: 11, Issue:6 Topics: Adult; Cognition Disorders; Depressive Disorder; Disability Evaluation; Evoked Potentials, Visual; F	2004
Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin. Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:12 Topics: Adolescent; Depressive Disorder; Diagnostic Errors; Disorders of Excessive Somnolence; Humans; Learn	2005
Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating. Brain research bulletin, 2006, Feb-15, Volume: 68, Issue:6 Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Depressive Disorder; Female; Genetic Predispositi	2006
Increased melatonin and delayed offset in menopausal depression: role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:1 Topics: Body Mass Index; Circadian Rhythm; Depressive Disorder; Estradiol; Female; Follicle Stimulating Horm	2008
Exacerbated mechanical allodynia in rats with depression-like behavior. Brain research, 2008, Mar-20, Volume: 1200 Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu	2008
Circadian rhythms in melatonin and cortisol secretion in depression. Advances in biochemical psychopharmacology, 1984, Volume: 39 Topics: Bipolar Disorder; Circadian Rhythm; Cushing Syndrome; Depressive Disorder; Dexamethasone; Humans; Hy	1984
Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology, 1984, Volume: 9, Issue:3 Topics: Adult; Age Factors; Bipolar Disorder; Body Height; Body Weight; Contraceptives, Oral; Depressive Dis	1984
A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biological psychiatry, 1984, Volume: 19, Issue:8 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Hypo	1984
Circadian rhythms and psychiatry. The British journal of psychiatry : the journal of mental science, 1984, Volume: 145 Topics: Circadian Rhythm; Depressive Disorder; Humans; Melatonin	1984
Circadian rhythm of plasma melatonin in endogenous depression. Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged	1984
Twenty-four-hour serum levels of TSH in affective disorders. Acta psychiatrica Scandinavica, 1984, Volume: 69, Issue:6 Topics: Acute Disease; Adult; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Humans; Lithium;	1984
Biological markers of melancholia and reclassification of depressive disorders. L'Encephale, 1982, Volume: 8, Issue:2 Topics: Depressive Disorder; Dexamethasone; Electroencephalography; Growth Hormone; Humans; Hydrocortisone;	1982
An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives. Psychiatry research, 1981, Volume: 4, Issue:1 Topics: Adolescent; Adult; Aged; Depression; Depressive Disorder; Desipramine; Female; Humans; Male; Melaton	1981
Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients. Neuropsychobiology, 1982, Volume: 8, Issue:5 Topics: Adult; Amitriptyline; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydro	1982
Primary early onset dysthymia, biochemical correlates of the therapeutic response to fluoxetine: II. Urinary metabolites of serotonin, norepinephrine, epinephrine and melatonin. Journal of affective disorders, 1994, Volume: 31, Issue:2 Topics: Adult; Age of Onset; Analysis of Variance; Creatinine; Depressive Disorder; Epinephrine; Female; Flu	1994
Geomagnetic storms: association with incidence of depression as measured by hospital admission. The British journal of psychiatry : the journal of mental science, 1994, Volume: 164, Issue:3 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Geological Phenomena; Geology; Hosp	1994
The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs. Sleep, 1993, Volume: 16, Issue:5 Topics: Body Temperature; Circadian Rhythm; Depressive Disorder; Female; Humans; Light; Male; Melatonin; Mid	1993
Seasonal affective disorder: response to light as measured by electroencephalogram, melatonin suppression, and cerebral blood flow. The British journal of psychiatry : the journal of mental science, 1993, Volume: 163 Topics: Bipolar Disorder; Brain; Cerebral Cortex; Circadian Rhythm; Contrast Sensitivity; Depressive Disorde	1993
Melatonin rhythms in seasonal affective disorder. The British journal of psychiatry : the journal of mental science, 1993, Volume: 163 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Individuality; Male;	1993
Melatonin in light treatment of patients with seasonal and nonseasonal depression. Acta psychiatrica Scandinavica, 1995, Volume: 92, Issue:4 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ph	1995
Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder. Psychiatry research, 1996, Jul-31, Volume: 63, Issue:2-3 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Mid	1996
Nocturnal serum melatonin profile in major depression in children and adolescents. Archives of general psychiatry, 1996, Volume: 53, Issue:11 Topics: Adolescent; Age Factors; Child; Circadian Rhythm; Depressive Disorder; Diagnosis, Differential; Fema	1996
Suicidal behavior is attenuated in patients with multiple sclerosis by treatment with electromagnetic fields. The International journal of neuroscience, 1996, Volume: 87, Issue:1-2 Topics: Adult; Circadian Rhythm; Depressive Disorder; Electromagnetic Fields; Female; Humans; Melatonin; Mid	1996
Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. The Journal of nervous and mental disease, 1997, Volume: 185, Issue:3 Topics: Adult; Depressive Disorder; Drug Therapy, Combination; Female; Fluoxetine; Humans; Melatonin; Sleep	1997
Neuroendocrine aspects of primary endogenous depression. XV: Mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls. Psychiatry research, 1997, Mar-24, Volume: 69, Issue:2-3 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ne	1997
Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression. Psychoneuroendocrinology, 1997, Volume: 22, Issue:1 Topics: Adult; Aged; Autoradiography; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Nor	1997
Lack of association between thyroid and pineal responses to antidepressant treatment. Depression, 1996, Volume: 4, Issue:2 Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Female; Humans; Male; Mel	1996
Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep. Psychiatry research, 1997, Aug-08, Volume: 71, Issue:3 Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Melatonin; Polys	1997
Cortisol in light treatment of seasonal and non-seasonal depression: relationship between melatonin and cortisol. Acta psychiatrica Scandinavica, 1997, Volume: 96, Issue:5 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Male	1997
Depression or cancer: the choice between serotonin or melatonin? Medical hypotheses, 1998, Volume: 50, Issue:5 Topics: Depression; Depressive Disorder; Humans; Hypothalamo-Hypophyseal System; Melatonin; Models, Biologic	1998
Affective disorder subtyped by psychomotor symptoms, monoamine oxidase, melatonin and cortisol: identification of patients with latent bipolar disorder. European archives of psychiatry and clinical neuroscience, 1998, Volume: 248, Issue:5 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Melatonin; Middl	1998
Diagnostic subgrouping of depressed patients by principal component analysis and visualized pattern recognition. Psychiatry research, 1998, Dec-14, Volume: 81, Issue:3 Topics: Adult; Biomarkers; Bipolar Disorder; Blood Platelets; Depressive Disorder; Dexamethasone; Female; Fo	1998
Melatonin suppression by light in euthymic bipolar and unipolar patients. Archives of general psychiatry, 2000, Volume: 57, Issue:6 Topics: Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female;	2000
The effects of electroconvulsive therapy on melatonin. The journal of ECT, 2000, Volume: 16, Issue:4 Topics: Adult; Aged; Antioxidants; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Male; Mel	2000
Circadian abnormalities in older adults. Journal of pineal research, 2001, Volume: 31, Issue:3 Topics: Adult; Aged; Aging; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Polysomnograp	2001
Depression and endogenous melatonin in postmenopausal women. Journal of affective disorders, 2002, Volume: 69, Issue:1-3 Topics: Aged; Aged, 80 and over; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Melatonin;	2002
Seasonal panic disorder: a possible variant of seasonal affective disorder. The International journal of neuroscience, 1992, Volume: 62, Issue:3-4 Topics: Adult; Alprazolam; Anxiety Disorders; Circadian Rhythm; Combined Modality Therapy; Depressive Disord	1992
Seasonal vulnerability to depression. Implications for etiology and treatment. L'Encephale, 1992, Volume: 18 Spec No 4 Topics: Corticotropin-Releasing Hormone; Depressive Disorder; Female; Humans; Light; Male; Melanocyte-Stimul	1992
Noradrenaline uptake inhibition increases melatonin secretion, a measure of noradrenergic neurotransmission, in depressed patients. Psychological medicine, 1992, Volume: 22, Issue:2 Topics: Adult; Depressive Disorder; Desipramine; Female; Humans; Male; Melatonin; Middle Aged; Norepinephrin	1992
[Disorders of circadian rhythms in depression]. L'Encephale, 1992, Volume: 18 Spec No 4 Topics: Adrenocorticotropic Hormone; Circadian Rhythm; Depressive Disorder; Growth Hormone-Releasing Hormone	1992
Blood levels of melatonin, serotonin, cortisol, and prolactin in relation to the circadian rhythm of platelet serotonin uptake. Psychiatry research, 1992, Volume: 43, Issue:2 Topics: Adult; Blood Platelets; Circadian Rhythm; Depressive Disorder; Humans; Hydrocortisone; Male; Melaton	1992
Effect of chronic antidepressant treatment with adinazolam and desipramine on melatonin output. Psychiatry research, 1992, Volume: 43, Issue:2 Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Depressive Disorder; Desipramine	1992
Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results. Biological psychiatry, 1992, Sep-01, Volume: 32, Issue:5 Topics: Adult; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Photoperiod; Phototherapy;	1992
Age, alcoholism and depression are associated with low levels of urinary melatonin. Journal of psychiatry & neuroscience : JPN, 1992, Volume: 17, Issue:5 Topics: Adult; Age Factors; Alcoholism; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; P	1992
Blood serotonin, serum melatonin and light therapy in healthy subjects and in patients with nonseasonal depression. Acta psychiatrica Scandinavica, 1992, Volume: 86, Issue:2 Topics: Depressive Disorder; Female; Humans; Male; Melatonin; Phototherapy; Serotonin	1992
Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. Biological psychiatry, 1992, Mar-15, Volume: 31, Issue:6 Topics: Adolescent; Child; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Personali	1992
Depressed nocturnal plasma melatonin levels in drug-free paranoid schizophrenics. Schizophrenia research, 1992, Volume: 7, Issue:1 Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Hypothalamo-Hypophysea	1992
Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Archives of general psychiatry, 1992, Volume: 49, Issue:7 Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Cross-Sectional Studies; Depressive Disorder; Dexam	1992
Pineal and adrenal function before and after refeeding in anorexia nervosa. Biological psychiatry, 1991, Aug-01, Volume: 30, Issue:3 Topics: Adrenal Glands; Adult; Anorexia Nervosa; Body Weight; Depressive Disorder; Female; Humans; Hydrocort	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Nocturnal melatonin and cortisol secretion in newly admitted psychiatric inpatients. Implications for affective disorders. European archives of psychiatry and clinical neuroscience, 1990, Volume: 240, Issue:1 Topics: Adult; Circadian Rhythm; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; M	1990
[Phototherapy of endogenous depression. A contribution to chronobiologic research in psychiatry]. Monographien aus dem Gesamtgebiete der Psychiatrie, 1990, Volume: 54 Topics: Adult; Body Temperature Regulation; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocort	1990
Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry research, 1990, Volume: 33, Issue:2 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Humans; Light; Melatonin; Psychiatric Statu	1990
The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging. Medical hypotheses, 1990, Volume: 31, Issue:3 Topics: Aging; Animals; Bipolar Disorder; Dementia; Depressive Disorder; Humans; Melatonin; Mental Disorders	1990
Lighting. Nonvisual effects. Scandinavian journal of work, environment & health, 1990, Volume: 16 Suppl 1 Topics: Circadian Rhythm; Depressive Disorder; Endocrine Glands; Humans; Lighting; Melatonin; Nervous System	1990
[Plasma and salivary melatonin assay and the clinical significance]. Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48 Suppl Topics: Biomarkers, Tumor; Brain Neoplasms; Circadian Rhythm; Depressive Disorder; Gas Chromatography-Mass S	1990
Sulphatoxy melatonin: an index of depression in anorexia nervosa and bulimia nervosa. Psychiatry research, 1990, Volume: 32, Issue:3 Topics: Anorexia Nervosa; Bulimia; Circadian Rhythm; Depressive Disorder; Female; Humans; Melatonin; Psychia	1990
Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. European archives of psychiatry and neurological sciences, 1986, Volume: 236, Issue:3 Topics: Adult; Chronic Disease; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydrocortisone; Hydr	1986
A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. The British journal of psychiatry : the journal of mental science, 1989, Volume: 155 Topics: Adult; Aged; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Male; Mela	1989
Melatonin and cortisol "switches" during mania, depression, and euthymia in a drug-free bipolar patient. The Journal of nervous and mental disease, 1989, Volume: 177, Issue:5 Topics: Adult; Bipolar Disorder; Blood Specimen Collection; Circadian Rhythm; Depressive Disorder; Evaluatio	1989
Light suppression of melatonin in unipolar depressed patients. Psychiatry research, 1989, Volume: 27, Issue:3 Topics: Adult; Circadian Rhythm; Depressive Disorder; Humans; Light; Male; Melatonin; Middle Aged	1989
Plasma melatonin levels in affective states. International journal of clinical pharmacology research, 1989, Volume: 9, Issue:2 Topics: Adolescent; Adult; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Mood Disorders	1989
Dawn and dusk simulation as a therapeutic intervention. Biological psychiatry, 1989, Apr-01, Volume: 25, Issue:7 Topics: Algorithms; Circadian Rhythm; Computers; Depressive Disorder; Humans; Lighting; Melatonin; Seasons	1989
Abnormal melatonin response to 5-methoxypsoralen in dementia. The American journal of psychiatry, 1989, Volume: 146, Issue:8 Topics: Adult; Aged; Aging; Dementia; Depressive Disorder; Female; Furocoumarins; Humans; Male; Melatonin; M	1989
Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality. Psychiatry research, 1989, Volume: 28, Issue:3 Topics: Adult; Amitriptyline; Body Temperature Regulation; Circadian Rhythm; Depressive Disorder; Female; Hu	1989
Neurochemical and neuroendocrine dysregulation in affective disorders. The Psychiatric clinics of North America, 1986, Volume: 9, Issue:2 Topics: Acetylcholine; Anxiety Disorders; Arousal; Brain; Depressive Disorder; Hormones; Humans; Melatonin;	1986
Dysregulation of neuroendocrine crossroads: depression, circadian rhythms and the retina--a hypothesis. Progress in neuro-psychopharmacology & biological psychiatry, 1987, Volume: 11, Issue:2-3 Topics: Circadian Rhythm; Depressive Disorder; Hormones; Humans; Hydrocortisone; Hypothalamus; Melatonin; Ne	1987
Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. Archives of general psychiatry, 1989, Volume: 46, Issue:1 Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Bulimia; Circadian Rhythm; Depressive Disorder; Fe	1989
Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test. Psychoneuroendocrinology, 1985, Volume: 10, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Corticotropin-Releasing Hormone; Depressive Di	1985
Desmethylimipramine treatment increases melatonin production in humans. Biological psychiatry, 1986, Volume: 21, Issue:4 Topics: Adult; Animals; Depressive Disorder; Desipramine; Female; Humans; Male; Melatonin; Middle Aged; Pine	1986
Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl. Psychiatry research, 1986, Volume: 17, Issue:2 Topics: Blood Platelets; Clorgyline; Depressive Disorder; Female; Humans; Male; Melatonin; Monoamine Oxidase	1986
Plasma melatonin concentrations in depression. The Australian and New Zealand journal of psychiatry, 1986, Volume: 20, Issue:3 Topics: Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Receptors, Adrenergic, beta	1986
Circadian rhythm of serotonin transport in human platelets. Psychopharmacology, 1986, Volume: 88, Issue:4 Topics: Adult; Biological Transport, Active; Blood Platelets; Circadian Rhythm; Depressive Disorder; Humans;	1986
Fluvoxamine-melatonin-stimulation-test (FMST) in patients with depressive disorders. Pharmacopsychiatry, 1988, Volume: 21, Issue:6 Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Dexamethasone; Female; Fluvoxamine; Humans;	1988
Acute changes in sleep-related hormone secretion of depressed patients following oral imipramine. Biological psychiatry, 1988, Volume: 24, Issue:5 Topics: Administration, Oral; Adult; Depressive Disorder; Drug Administration Schedule; Electroencephalograp	1988
A comparison of melatonin secretion in depressed patients and normal subjects. The British journal of psychiatry : the journal of mental science, 1988, Volume: 152 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged	1988
Why not treat melancholia with melatonin and tryptophan and treat seasonal affective disorders with bright light? Medical hypotheses, 1988, Volume: 27, Issue:4 Topics: Biomarkers; Depressive Disorder; Humans; Melatonin; Models, Biological; Mood Disorders; Phototherapy	1988
Melatonin secretion in depression. The British journal of psychiatry : the journal of mental science, 1988, Volume: 153 Topics: Benzodiazepines; Depressive Disorder; Humans; Male; Melatonin	1988
Response of the melatonin cycle to phototherapy for Seasonal Affective Disorder. Short note. Journal of neural transmission, 1988, Volume: 72, Issue:2 Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Phototherapy; Seasons	1988
Melatonin in serum and urine in patients with idiopathic pain syndromes. Psychiatry research, 1987, Volume: 22, Issue:3 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ne	1987
The timing of phototherapy: effects on clinical response and the melatonin cycle. Psychopharmacology bulletin, 1987, Volume: 23, Issue:3 Topics: Depressive Disorder; Humans; Melatonin; Phototherapy; Time Factors	1987
Patterns of melatonin rhythms in depression. Journal of neural transmission. Supplementum, 1986, Volume: 21 Topics: Adult; Circadian Rhythm; Depression; Depressive Disorder; Desipramine; Female; Humans; Isoproterenol	1986
Melatonin circadian rhythm in childhood depression. Journal of the American Academy of Child and Adolescent Psychiatry, 1987, Volume: 26, Issue:3 Topics: Adolescent; Child; Circadian Rhythm; Depressive Disorder; Humans; Male; Melatonin	1987
Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patients. Acta psychiatrica Scandinavica, 1987, Volume: 76, Issue:3 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Re	1987
Effect of imipramine on the circadian rhythm of plasma melatonin in unipolar depression. Chronobiology international, 1986, Volume: 3, Issue:1 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Imipramine; Male; Melatonin; Mid	1986
Phototherapy of seasonal affective disorder. Time of day and suppression of melatonin are not critical for antidepressant effects. Archives of general psychiatry, 1986, Volume: 43, Issue:9 Topics: Circadian Rhythm; Depressive Disorder; Evaluation Studies as Topic; Female; Humans; Male; Melatonin;	1986
6-Sulphatoxy melatonin in melancholia. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Adult; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; Melatonin; Middle A	1985
Melatonin as depression marker. Biological psychiatry, 1985, Volume: 20, Issue:5 Topics: Depressive Disorder; Humans; Melatonin	1985
Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. The American journal of psychiatry, 1985, Volume: 142, Issue:7 Topics: Adult; Circadian Rhythm; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; M	1985
Rapid antidepressant activity of destyr gamma endorphin: correlation with urinary melatonin. Biological psychiatry, 1985, Volume: 20, Issue:9 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Endorphins; Female; Humans; Male; Melatonin; Mid	1985
Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta psychiatrica Scandinavica, 1985, Volume: 71, Issue:4 Topics: Adult; Circadian Rhythm; Depressive Disorder; Dexamethasone; Female; Grief; Humans; Hydrocortisone;	1985
Nocturnal serum melatonin in major depressive disorder before and after desmethylimipramine treatment. Psychopharmacology bulletin, 1985, Volume: 21, Issue:3 Topics: Adult; Circadian Rhythm; Depressive Disorder; Desipramine; Humans; Male; Melatonin	1985
The effect of desipramine upon melatonin and cortisol secretion in depressed and normal subjects. The British journal of psychiatry : the journal of mental science, 1985, Volume: 147 Topics: Adolescent; Adult; Depressive Disorder; Desipramine; Female; Humans; Hydrocortisone; Male; Melatonin	1985

melatonin and Depressive Disorder