melatonin has been researched along with Depression in 197 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Studies were eligible if they: (1) were a clinical trial; (2) enrolled adults; (3) assessed the effect of melatonin supplementation on serum concentration of BDNF or depression score." | 9.41 | Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials. ( Darand, M; Feltham, BA; Rouhani, MH; Saraf-Bank, S; Shokri-Mashhadi, N; Yahay, M, 2023) |
| "This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment." | 9.34 | Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. ( Biazús, JV; Caumo, W; Fregni, F; Palmer, ACS; Santos, V; Souza, A; Torres, ILS; Zortea, M, 2020) |
| "Melatonin showed no prophylactic antidepressant effect following acute coronary syndrome." | 9.30 | The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Grummedal, O; Hansen, CH; Hansen, JR; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M; Zahid, JA, 2019) |
| "The purpose is to examine the effects of melatonin supplementation on sleep, mood, and hot flashes in postmenopausal breast cancer survivors." | 9.19 | A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes. ( Chen, WY; Gantman, K; Giobbie-Hurder, A; Parker, LM; Savoie, J; Scheib, R; Schernhammer, ES, 2014) |
| "Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer." | 9.17 | Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013) |
| "The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects." | 9.17 | A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013) |
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 9.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 9.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| " Such pathophysiological processes include increases in oxidative and nitrosative stress, pro-inflammatory immune responses, especially T helper (Th)17 cell proliferation and activation, tryptophan catabolites, pain, fatigue and increased levels of depression." | 8.93 | Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin. ( Anderson, G; Rodriguez, M; Wootla, B, 2016) |
| "In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia." | 8.31 | Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023) |
| "Testing the hypothesis that a sleep-light intervention, which phase-advances melatonin rhythms, will improve perimenopausal-postmenopausal (P-M; by follicle-stimulating hormone) depression." | 8.31 | Sleep-light interventions that shift melatonin rhythms earlier improve perimenopausal and postmenopausal depression: preliminary findings. ( Dawes, SE; Elliott, JA; Hauger, RL; Lopez, AM; Martinez, LF; Meliska, CJ; Parry, BL; Sorenson, DL, 2023) |
| " In this sense, temozolomide, an alkylating/anti-proliferating agent used in treating brain cancer, is associated with decreased cognitive functions and depression." | 8.31 | Melatonin Prevents Depression but Not Anxiety-like Behavior Produced by the Chemotherapeutic Agent Temozolomide: Implication of Doublecortin Cells and Hilar Oligodendrocytes. ( Cabrera-Muñoz, EA; Díaz-Yañez, L; Meneses-San Juan, D; Ramírez-Rodríguez, GB; Reyes-Galindo, V; Vega-Rivera, NM, 2023) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 7.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| "This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters." | 7.85 | Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 7.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| "The present study was aimed at evaluating the rapidity and duration of melatonin as an antidepressant in a rat model of depression." | 7.85 | Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress. ( Li, Q; Lian, B; Sun, H; Sun, L; Sun, X; Wang, G; Wang, M; Wang, Y, 2017) |
| ""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial." | 7.85 | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017) |
| "Disrupted circadian rhythm of melatonin secretion in depression shows a relationship with the exacerbation of inflammatory processes." | 7.83 | Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. ( Araszkiewicz, A; Just, MJ; Ogłodek, EA; Szromek, AR, 2016) |
| "To explore the effects of Kaixin Powder (, KXP) on melatonin receptor (MR) expression and (125)I-Mel binding affinity in a depression rat model." | 7.81 | Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. ( Cai, C; Gao, C; Guan, JH; Guo, J; Huang, YL; Liang, XB; Qian, LQ; Zhao, GP, 2015) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 7.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "To observe the effects of electroacupuncture (EA) on circadian rhythm of temperature and melatonin (MT) in depression rats model induced by chronic stress, so as to explore the biological mechanism of EA for depression." | 7.80 | [Effects of electroacupuncture on circadian rhythm of temperature and melatonin in depression rats model induced by chronic stress]. ( Han, XB; Li, ZG; Mo, YP; Song, HT; Yao, HJ; Zhang, TT, 2014) |
| "To study the effect of Kaixin San on the rate-limiting enzyme in biosynthesis of melatonin (MT) and pineal body in rat depression model." | 7.78 | [Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model]. ( Cai, C; Liang, X; Peng, X; Qian, G; Zhao, G, 2012) |
| "To investigate the differences in cortisol and melatonin concentrations between children with frequent episodic tension-type headache (FETTH) and healthy children." | 7.77 | Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children. ( Ambite-Quesada, S; Arroyo-Morales, M; Fernández-de-las-Peñas, C; Fernández-Mayoralas, DM; Linares-García-Valdecasas, R; Palomar-Gallego, MA; Rivas-Martínez, I, 2011) |
| " Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)." | 7.75 | We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009) |
| "A recent study in the JAMA described the effects of long-term daily treatment with whole-day bright light in elderly patients with dementia, with or without the addition of melatonin (2." | 7.74 | [Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile]. ( van Marum, RJ, 2008) |
| " The purpose of this exploratory study was to compare women with breast cancer to healthy control women on measures of salivary cortisol, urinary catecholamines, overnight urinary melatonin, and self-reported sleep quality, symptoms of stress, depression, anxiety and mood disturbance, to determine if discernable patterns of dysregulations across systems were apparent." | 7.74 | Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls. ( Campbell, TS; Carlson, LE; Garland, SN; Grossman, P, 2007) |
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 7.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 7.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| " The investigation of melatonin rhythm may thus provide an indirect clue to neurotransmitter alterations, and allow a biological comparison with depression." | 7.70 | Plasma melatonin and cortisol in patients with obsessive-compulsive disorder: relationship with axillary temperature, physical activity, and clinical symptoms. ( Bogdan, A; Bourdel, MC; Hantouche, E; Millet, B; Olié, JP; Poirier, MF; Touitou, Y, 1998) |
| "Sequential measures of daytime and nighttime sulphatoxy-melatonin (aMT6s) in 10 female patients with anorexia nervosa (AN) and 12 female patients with concurrent AN with bulimic symptoms (AN + BN) were compared with 13 female control subjects." | 7.68 | The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa. ( Brown, GM; Ford, CG; Kennedy, SH; Ralevski, E, 1993) |
| " Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin." | 7.68 | Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990) |
| "Melatonin has been suggested as a highly cytoprotective and neuroprotective substance and shown to stimulate all stages of neuroplasticity in animal models." | 6.72 | Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression. ( Kim, YK; Na, KS; Won, E, 2021) |
| "Melatonin has been used for improving sleep in patients with insomnia mainly because it does not cause hangover or show any addictive potential." | 6.48 | Melatonin and its analogs in insomnia and depression. ( Brown, GM; Brzezinski, A; Cardinali, DP; Srinivasan, V, 2012) |
| "Depression is a common chronic psychiatric illness, which is resistant to medical treatments." | 5.91 | Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. ( Fang, Y; Hao, J; He, Y; Huang, H; Li, R; Liu, X; Ran, L; Wang, M; Wang, W; Wang, X; Yao, D, 2023) |
| "Melatonin treatment could significantly reverse the endoplasmic reticulum stress and JNK phosphorylation induced by CUMS." | 5.62 | Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus. ( Ju, X; Li, J; Song, M; Wang, S; Xu, X; Yan, P; Yu, Z, 2021) |
| "Depression is a debilitating psychiatric disorder with a huge socioeconomic burden, and its treatment relies on antidepressants including selective serotonin reuptake inhibitors (SSRIs)." | 5.48 | Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF-TrkB Signaling. ( Ji, YT; Li, K; Li, XY; Shen, S; Wang, XD; Zhang, LS, 2018) |
| "Melatonin treatment decreased immobility in comparison with the placebo group, reflecting an antidepressant-like effect." | 5.43 | Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels. ( Djordjevic, J; Dronjak, S; Jasnic, N; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2016) |
| "Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies." | 5.39 | Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. ( Atanasova, D; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Moyanova, S; Pechlivanova, D; Petkova, Z; Stoynev, A; Tchekalarova, J, 2013) |
| "Melatonin has significant bearing on sleep architecture and a lack of melatonin may desynchronize endogenous rhythms allowing subsyndromal depression to manifest." | 5.36 | Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors. ( Kayumov, L; Marcu, S; Rahman, SA; Shapiro, CM, 2010) |
| "This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment." | 5.34 | Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. ( Biazús, JV; Caumo, W; Fregni, F; Palmer, ACS; Santos, V; Souza, A; Torres, ILS; Zortea, M, 2020) |
| "Melatonin showed no prophylactic antidepressant effect following acute coronary syndrome." | 5.30 | The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Grummedal, O; Hansen, CH; Hansen, JR; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M; Zahid, JA, 2019) |
| "in seven male depressed patients with melancholia and five healthy male control subjects." | 5.27 | Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986) |
| "Depression has become one of the most commonly prevalent neuropsychiatric disorders, and the main characteristics of depression are sleep disorders and melatonin secretion disorders caused by circadian rhythm disorders." | 5.22 | Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment. ( Jiang, YJ; Liu, J; Wang, YH; Wang, YQ; Zhao, HQ; Zou, MS, 2022) |
| "Reduced levels of melatonin have been associated with severe depression." | 5.22 | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. ( Cunningham, JL; Ekselius, L; Papadopoulos, FC; Ramklint, M; Stridsberg, M; Sundberg, I, 2016) |
| "The purpose is to examine the effects of melatonin supplementation on sleep, mood, and hot flashes in postmenopausal breast cancer survivors." | 5.19 | A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes. ( Chen, WY; Gantman, K; Giobbie-Hurder, A; Parker, LM; Savoie, J; Scheib, R; Schernhammer, ES, 2014) |
| " To determine (1) the serum baseline daily variations and nocturnal excretion of melatonin in ADHD subtypes and (2) the effect of chronic administration of methylphenidate, as well as the effects on symptomatology, 136 children with ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR criteria) were divided into subgroups using the "Children's Depression Inventory" (CDI)." | 5.19 | Methylphenidate ameliorates depressive comorbidity in ADHD children without any modification on differences in serum melatonin concentration between ADHD subtypes. ( Cubero-Millán, I; Fernández-López, L; Luna-del-Castillo, JD; Machado-Casas, I; Martínez-Serrano, S; Molina-Carballo, A; Muñoz-Hoyos, A; Ruiz-López, A; Tortosa-Pinto, P; Uberos, J, 2014) |
| "Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer." | 5.17 | Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013) |
| "The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects." | 5.17 | A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013) |
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 5.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "Melatonin treatment significantly reduced depression scores in the depressed patients as measured by the CES-D and Hamilton Depression Rating Scale--17." | 5.14 | Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( Kayumov, L; Rahman, SA; Shapiro, CM, 2010) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| " Twenty-four outpatients meeting DSM-III-R criteria for Major Depression received treatment with either fluvoxamine or imipramine for 6 weeks while participating in a placebo-controlled double-blind clinical trial." | 5.09 | Noradrenergic function and clinical outcome in antidepressant pharmacotherapy. ( Ekstrom, RD; Golden, RN; Lydiard, RB; Mason, GA; Miller, HL, 2001) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 5.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| "Melatonin intervention has no significant influence on well-being, sleepiness, sleep quality, pain intensity after 1 and 3 hours, headache, depression, and dizziness for laparoscopic cholecystectomy." | 5.01 | The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. ( Wang, Y; Xu, H; Yang, J; Zhang, J, 2019) |
| " Such pathophysiological processes include increases in oxidative and nitrosative stress, pro-inflammatory immune responses, especially T helper (Th)17 cell proliferation and activation, tryptophan catabolites, pain, fatigue and increased levels of depression." | 4.93 | Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin. ( Anderson, G; Rodriguez, M; Wootla, B, 2016) |
| "Bright light treatment is the most potent melatonin suppressor and circadian phase shifter and is a safe nonpharmacologic antidepressant for seasonal depression." | 4.82 | Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. ( Oren, DA; Postolache, TT, 2005) |
| "In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia." | 4.31 | Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 3.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| "Our results demonstrated that melatonin possesses potent protective effect against the depression and anxiety induced by LPS." | 3.88 | Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress. ( Bahbiti, Y; Benmhammed, H; Berkiks, I; El Hasnaoui, A; El Hessni, A; Mesfioui, A; Mouden, S; Nakache, R; Ouichou, A; Touil, T, 2018) |
| "This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters." | 3.85 | Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 3.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| "The present study was aimed at evaluating the rapidity and duration of melatonin as an antidepressant in a rat model of depression." | 3.85 | Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress. ( Li, Q; Lian, B; Sun, H; Sun, L; Sun, X; Wang, G; Wang, M; Wang, Y, 2017) |
| ""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial." | 3.85 | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017) |
| " In the current study the association between diurnal pattern of key phase markers (melatonin, corticosterone, and core body temperature) and anhedonic-like behavior was investigated using the highly validated rat chronic mild stress (CMS) model of depression." | 3.83 | Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression. ( Bouzinova, EV; Christiansen, SL; Højgaard, K; Wiborg, O, 2016) |
| "Disrupted circadian rhythm of melatonin secretion in depression shows a relationship with the exacerbation of inflammatory processes." | 3.83 | Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. ( Araszkiewicz, A; Just, MJ; Ogłodek, EA; Szromek, AR, 2016) |
| "To explore the effects of Kaixin Powder (, KXP) on melatonin receptor (MR) expression and (125)I-Mel binding affinity in a depression rat model." | 3.81 | Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. ( Cai, C; Gao, C; Guan, JH; Guo, J; Huang, YL; Liang, XB; Qian, LQ; Zhao, GP, 2015) |
| " We sought to address these questions by 1) feeding pregnant rats with diets sufficient or deficient in DHA during gestation and lactation; 2) weaning their male offspring to diets that were sufficient or deficient in DHA; and 3) assessing depression-related behaviors (forced swim test), plasma biomarkers [brain-derived neurotrophic factor (BDNF), serotonin, and melatonin], and brain biomarkers (BDNF) in the offspring before and after puberty." | 3.81 | Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats. ( Butt, CM; Salem, N; Weiser, MJ; Wynalda, K, 2015) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 3.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "In contrast with randomized controlled trials, observational studies have suggested that physiological levels of melatonin are reduced in patients with dementia or depression, but the relationship has not been evaluated in large populations." | 3.81 | Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort. ( Iwamoto, J; Kataoka, H; Kurumatani, N; Morikawa, M; Obayashi, K; Saeki, K; Tanaka, K; Tone, N, 2015) |
| "Decreased circulating melatonin is implicated in depression." | 3.80 | Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in Zucker diabetic fatty rats. ( Ben, H; Li, S; McCabe, MF; Rong, P; Wang, S; Wang, X; Zhai, X; Zhao, J, 2014) |
| " Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition." | 3.79 | Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013) |
| "To study the effect of Kaixin San on the rate-limiting enzyme in biosynthesis of melatonin (MT) and pineal body in rat depression model." | 3.78 | [Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model]. ( Cai, C; Liang, X; Peng, X; Qian, G; Zhao, G, 2012) |
| "To investigate the differences in cortisol and melatonin concentrations between children with frequent episodic tension-type headache (FETTH) and healthy children." | 3.77 | Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children. ( Ambite-Quesada, S; Arroyo-Morales, M; Fernández-de-las-Peñas, C; Fernández-Mayoralas, DM; Linares-García-Valdecasas, R; Palomar-Gallego, MA; Rivas-Martínez, I, 2011) |
| "6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression." | 3.76 | Sleep disturbance and melatonin levels following traumatic brain injury. ( Parcell, DL; Phipps-Nelson, J; Ponsford, JL; Rajaratnam, SM; Redman, JR; Shekleton, JA, 2010) |
| " Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)." | 3.75 | We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009) |
| "(1) When an antidepressant is considered a necessary addition to psychological support in treating patients with depression, the first-line drug is a tricyclic such as clomipramine or a selective serotonin reuptake inhibitor (SSRI) such as paroxetine; (2) Agomelatine, a melatonin receptor agonist, is approved in the European Union for the treatment of depression; (3) Available evaluation does not include any clinical trials designed to compare the efficacy of agomelatine with that of a tricyclic or a selective serotonin reuptake inhibitor." | 3.75 | Agomelatine: new drug. Adverse effects and no proven efficacy. ( , 2009) |
| "A recent study in the JAMA described the effects of long-term daily treatment with whole-day bright light in elderly patients with dementia, with or without the addition of melatonin (2." | 3.74 | [Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile]. ( van Marum, RJ, 2008) |
| " The purpose of this exploratory study was to compare women with breast cancer to healthy control women on measures of salivary cortisol, urinary catecholamines, overnight urinary melatonin, and self-reported sleep quality, symptoms of stress, depression, anxiety and mood disturbance, to determine if discernable patterns of dysregulations across systems were apparent." | 3.74 | Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls. ( Campbell, TS; Carlson, LE; Garland, SN; Grossman, P, 2007) |
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 3.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 3.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| "We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression." | 3.70 | Melatonin excretion is not related to sleep in the elderly. ( Elliott, JA; Kripke, DF; Youngstedt, SD, 1998) |
| " The investigation of melatonin rhythm may thus provide an indirect clue to neurotransmitter alterations, and allow a biological comparison with depression." | 3.70 | Plasma melatonin and cortisol in patients with obsessive-compulsive disorder: relationship with axillary temperature, physical activity, and clinical symptoms. ( Bogdan, A; Bourdel, MC; Hantouche, E; Millet, B; Olié, JP; Poirier, MF; Touitou, Y, 1998) |
| " A plausible mechanism related to melatonin and depression provides a direction for additional laboratory research and epidemiologic evaluation." | 3.70 | Exposure to electromagnetic fields and suicide among electric utility workers: a nested case-control study. ( Cai, J; Kleckner, RC; Loomis, D; Savitz, DA; van Wijngaarden, E, 2000) |
| "Sequential measures of daytime and nighttime sulphatoxy-melatonin (aMT6s) in 10 female patients with anorexia nervosa (AN) and 12 female patients with concurrent AN with bulimic symptoms (AN + BN) were compared with 13 female control subjects." | 3.68 | The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa. ( Brown, GM; Ford, CG; Kennedy, SH; Ralevski, E, 1993) |
| " Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin." | 3.68 | Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990) |
| " Examples are cited from our studies of the effects of monoamine oxidase inhibitors and other antidepressants on noradrenergic-serotonergic interactions that affect melatonin release and other neuroendocrine responses, on some additional functional end-points, and on depressive mood and other symptoms in patients with depression or other tricyclic-responsive disorders." | 3.67 | How antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of antidepressant drug treatment. ( Aulakh, CS; Garrick, NA; Murphy, DL, 1986) |
| "Melatonin plays an essential role in the regulation of circadian rhythms." | 2.82 | Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression. ( Baig, AA; Bardhan, M; Bhutra, P; Boiko, DI; Chopra, H; Hasan, MM; Kazmi, SK; Shkodina, AD; Skrypnikov, AM, 2022) |
| "Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1." | 2.74 | Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. ( Aramburu, O; Garzón, C; Guerrero, JM; Guzmán, T, 2009) |
| "Melatonin treatment is of interest in remitted patients with mood disorder to prevent relapses or recurrences, if a complaint of insomnia, poor sleep quality or phase delay syndrome is associated." | 2.72 | Biological rhythms and chronotherapeutics in depression. ( Geoffroy, PA; Palagini, L, 2021) |
| "Depression was more frequently associated with circadian alterations than euthymia." | 2.55 | Chronotype and circadian rhythm in bipolar disorder: A systematic review. ( Abreu, RLC; de Bruin, PFC; de Bruin, VMS; Linhares Neto, VB; Melo, MCA, 2017) |
| " This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies." | 2.53 | Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions. ( Fu, W; Liu, J; Wang, Y, 2016) |
| "Melatonin has been used for improving sleep in patients with insomnia mainly because it does not cause hangover or show any addictive potential." | 2.48 | Melatonin and its analogs in insomnia and depression. ( Brown, GM; Brzezinski, A; Cardinali, DP; Srinivasan, V, 2012) |
| "Depression is a disabling condition which adversely affects a person's family, social and work life, and that is associated with a heavy burden to society." | 2.48 | Emerging targets for the pharmacological treatment of depression: focus on melatonergic system. ( Bellantuono, C; Catena-Dell'Osso, M; Marazziti, D; Rotella, F, 2012) |
| "Melatonin is a neurohormone that is believed to be involved in a wide range of physiological functions." | 2.43 | Therapeutic potential of melatonin ligands. ( Boutin, JA; Delagrange, P, 2006) |
| "Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals." | 2.43 | Melatonin: Nature's most versatile biological signal? ( Cardinali, DP; Hardeland, R; Maestroni, GJ; Pandi-Perumal, SR; Poeggeler, B; Srinivasan, V, 2006) |
| "Fibromyalgia has gender, age and probably hormonal associations." | 2.43 | Menopause related sleep disorders. ( Eichling, PS; Sahni, J, 2005) |
| "Melatonin profiles are a diagnostic tool to distinguish between several forms of depression, like major depression, winter depression (SAD), unipolar depression, delayed sleep phase syndrome (DSPS)." | 2.41 | Melatonin deficiencies in women. ( Herold, J; Rohr, UD, 2002) |
| "Depression is a common chronic psychiatric illness, which is resistant to medical treatments." | 1.91 | Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. ( Fang, Y; Hao, J; He, Y; Huang, H; Li, R; Liu, X; Ran, L; Wang, M; Wang, W; Wang, X; Yao, D, 2023) |
| "Venlafaxine + melatonin treatment improves depression-like behaviour, pentobarbital sodium experimental sleep latency, and sleep duration in CUMS +SD rats." | 1.72 | Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. ( Han, YS; Jiang, HX; Li, CY; Li, ZR; Liu, DG; Wang, YH; Xie, S; Zou, MS, 2022) |
| "Depression is common in older people and is associated with underlying brain change increasing the risk of dementia." | 1.56 | Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study. ( Gordon, C; Hickie, IB; Hoyos, CM; Lewis, SJG; Naismith, SL; Norrie, L; Terpening, Z, 2020) |
| "Fluoxetine and melatonin treatments decreased TBARS in both cortices." | 1.46 | The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. ( Boudah, A; Jasmin, L; Rebai, R, 2017) |
| "Pretreatment with melatonin was found to renew BrdU and DCX expression in the dentate gyrus." | 1.40 | Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain. ( Govitrapong, P; Mahanam, T; Ruksee, N; Tongjaroenbuangam, W, 2014) |
| "Melatonin is a hormone with well-known chronobiotic and hypnotic effects." | 1.40 | Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014) |
| "Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies." | 1.39 | Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. ( Atanasova, D; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Moyanova, S; Pechlivanova, D; Petkova, Z; Stoynev, A; Tchekalarova, J, 2013) |
| "Melatonin has significant bearing on sleep architecture and a lack of melatonin may desynchronize endogenous rhythms allowing subsyndromal depression to manifest." | 1.36 | Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors. ( Kayumov, L; Marcu, S; Rahman, SA; Shapiro, CM, 2010) |
| "Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
| "Melatonin has been demonstrated to increase activity in the forced swim test (FST), a putative model of antidepressant efficacy, indicating that it may possess antidepressant-like qualities." | 1.32 | Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats. ( Brotto, LA; Gorzalka, BB; Hill, MN; Lee, TT, 2003) |
| "Melatonin suppression was not significantly different with upper or middle field illumination." | 1.31 | Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers. ( Elliott, JA; Kripke, DF; Smith, JS; Youngstedt, SD, 2002) |
| "Melatonin levels were significantly lower in patients with insomnia and obese postmenopausal females than in controls." | 1.31 | Melatonin in postmenopausal females. ( Blaicher, W; Gruber, DM; Huber, JC; Imhof, MH; Sator, MO; Schneeberger, C; Speck, E, 2000) |
| " Male and female Long-Evans rats received either a regimen of chronic administration of melatonin or the control condition for 14 days via the drinking water." | 1.31 | Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin. ( Barr, AM; Brotto, LA; Gorzalka, BB, 2000) |
| "Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM." | 1.31 | Hypothalamic involvement in chronic migraine. ( Abucham, J; Cipolla-Neto, J; Peres, MF; Sanchez del Rio, M; Seabra, ML; Silberstein, SD; Tufik, S; Zukerman, E, 2001) |
| "in the ESRD patients were comparable with those obtained in the normal control group." | 1.29 | Serum melatonin and 6-sulfatoxymelatonin in end-stage renal disease: effect of hemodialysis. ( Oveisi, F; Shaw, V; Sporty, LD; Vaziri, ND; Wierszbiezki, M, 1993) |
| "in seven male depressed patients with melancholia and five healthy male control subjects." | 1.27 | Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986) |
| "Each subject's risk of developing breast cancer, cardiovascular diseases resulting from an elevated blood pressure, and emotional conditions was numerically evaluated according to epidemiologic questionnaires." | 1.27 | Circadian characteristics of urinary melatonin from clinically healthy young women at different civilization disease risks. ( Cornelissen, G; Halberg, E; Halberg, F; Haus, E; Kawasaki, T; Matsuoka, M; Omae, T; Ueno, M; Uezono, K; Wetterberg, L, 1986) |
| " An inverse correlation between plasma levels of DMI and plasma levels of melatonin-like immunoreactivity was found in the group of clinical responders to the chronic administration of the drug." | 1.26 | An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives. ( Halbreich, U; Klein, DF; Quitkin, FM; Stewart, J; Weinberg, U; Weitzman, ED, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (13.71) | 18.7374 |
| 1990's | 21 (10.66) | 18.2507 |
| 2000's | 40 (20.30) | 29.6817 |
| 2010's | 80 (40.61) | 24.3611 |
| 2020's | 29 (14.72) | 2.80 |
| Authors | Studies |
|---|---|
| Estrada-Reyes, R | 3 |
| Quero-Chávez, DB | 1 |
| Trueta, C | 2 |
| Miranda, A | 1 |
| Valdés-Tovar, M | 3 |
| Alarcón-Elizalde, S | 1 |
| Oikawa-Sala, J | 3 |
| Argueta, J | 3 |
| Constantino-Jonapa, LA | 1 |
| Muñoz-Estrada, J | 1 |
| Dubocovich, ML | 4 |
| Benítez-King, G | 4 |
| Kanova, M | 1 |
| Kohout, P | 1 |
| Wang, YQ | 1 |
| Jiang, YJ | 1 |
| Zou, MS | 2 |
| Liu, J | 3 |
| Zhao, HQ | 1 |
| Wang, YH | 2 |
| Won, E | 1 |
| Na, KS | 1 |
| Kim, YK | 1 |
| Kholghi, G | 1 |
| Eskandari, M | 1 |
| Shokouhi Qare Saadlou, MS | 1 |
| Zarrindast, MR | 1 |
| Vaseghi, S | 1 |
| Boiko, DI | 1 |
| Shkodina, AD | 1 |
| Hasan, MM | 1 |
| Bardhan, M | 1 |
| Kazmi, SK | 1 |
| Chopra, H | 1 |
| Bhutra, P | 1 |
| Baig, AA | 1 |
| Skrypnikov, AM | 1 |
| Xie, LL | 1 |
| Rui, C | 1 |
| Li, ZZ | 1 |
| Li, SS | 1 |
| Fan, YJ | 1 |
| Qi, MM | 1 |
| Liu, W | 2 |
| Huang, Z | 1 |
| Xia, J | 1 |
| Cui, Z | 1 |
| Li, L | 1 |
| Qi, Z | 1 |
| Li, ZR | 1 |
| Liu, DG | 1 |
| Xie, S | 1 |
| Han, YS | 1 |
| Li, CY | 1 |
| Jiang, HX | 1 |
| Shokri-Mashhadi, N | 1 |
| Darand, M | 1 |
| Rouhani, MH | 1 |
| Yahay, M | 1 |
| Feltham, BA | 1 |
| Saraf-Bank, S | 1 |
| Rosa, ER | 1 |
| Jesús, ME | 1 |
| Gloria, BK | 1 |
| Nikoui, V | 3 |
| Hosseinzadeh, A | 3 |
| Khotab, SJ | 3 |
| Mousavi, SZ | 3 |
| Abolmaali, M | 3 |
| Mehrzadi, S | 3 |
| Yılmaz, S | 1 |
| Öner, P | 1 |
| de Oliveira Moura Araújo, E | 1 |
| Gavioli, EC | 1 |
| Holanda, VAD | 1 |
| da Silva, VC | 1 |
| Oliveira Nunes Messias, TB | 1 |
| Dutra, LMG | 1 |
| de Oliveira, MC | 1 |
| Ramos do Egypto Queiroga, RC | 1 |
| Guerra, GCB | 1 |
| Soares, JKB | 1 |
| Parry, BL | 5 |
| Meliska, CJ | 3 |
| Sorenson, DL | 3 |
| Martinez, LF | 3 |
| Lopez, AM | 3 |
| Dawes, SE | 1 |
| Elliott, JA | 4 |
| Hauger, RL | 1 |
| Wilson, JB | 1 |
| Epstein, M | 1 |
| Lopez, B | 1 |
| Brown, AK | 1 |
| Lutfy, K | 1 |
| Friedman, TC | 1 |
| Cabrera-Muñoz, EA | 1 |
| Ramírez-Rodríguez, GB | 3 |
| Díaz-Yañez, L | 1 |
| Reyes-Galindo, V | 1 |
| Meneses-San Juan, D | 1 |
| Vega-Rivera, NM | 4 |
| Yao, D | 1 |
| Li, R | 1 |
| Hao, J | 1 |
| Huang, H | 1 |
| Wang, X | 2 |
| Ran, L | 1 |
| Fang, Y | 1 |
| He, Y | 1 |
| Wang, W | 1 |
| Liu, X | 2 |
| Wang, M | 2 |
| Mendoza, J | 1 |
| Madsen, MT | 3 |
| Zahid, JA | 1 |
| Hansen, CH | 1 |
| Grummedal, O | 1 |
| Hansen, JR | 1 |
| Isbrand, A | 2 |
| Andersen, UO | 2 |
| Andersen, LJ | 2 |
| Taskiran, M | 2 |
| Simonsen, E | 2 |
| Gögenur, I | 4 |
| Ergenc, M | 1 |
| Ozacmak, HS | 1 |
| Turan, I | 1 |
| Ozacmak, VH | 1 |
| Palacios-Cabriales, DM | 1 |
| Ortiz-López, L | 3 |
| Estrada-Camarena, EM | 2 |
| Palmer, ACS | 1 |
| Zortea, M | 1 |
| Souza, A | 1 |
| Santos, V | 1 |
| Biazús, JV | 1 |
| Torres, ILS | 1 |
| Fregni, F | 2 |
| Caumo, W | 3 |
| Touitou, Y | 2 |
| Touitou, D | 1 |
| Reinberg, A | 1 |
| Hoyos, CM | 1 |
| Gordon, C | 2 |
| Terpening, Z | 1 |
| Norrie, L | 1 |
| Lewis, SJG | 1 |
| Hickie, IB | 2 |
| Naismith, SL | 1 |
| Granados-Juárez, A | 1 |
| Geoffroy, PA | 1 |
| Palagini, L | 1 |
| Wang, S | 3 |
| Xu, X | 1 |
| Ju, X | 1 |
| Li, J | 1 |
| Yan, P | 1 |
| Yu, Z | 1 |
| Song, M | 1 |
| Laudisio, D | 1 |
| Barrea, L | 1 |
| Pugliese, G | 1 |
| Aprano, S | 1 |
| Castellucci, B | 1 |
| Savastano, S | 1 |
| Colao, A | 1 |
| Muscogiuri, G | 1 |
| Porteous, M | 1 |
| Fogel, S | 1 |
| Ray, L | 1 |
| Carpenter, JS | 1 |
| Louati, K | 1 |
| Robillard, R | 1 |
| Kudo, N | 1 |
| Shinohara, H | 1 |
| Kagabu, S | 1 |
| Kodama, H | 1 |
| Murray, JM | 1 |
| Sletten, TL | 1 |
| Magee, M | 1 |
| Lovato, N | 1 |
| Bartlett, DJ | 1 |
| Kennaway, DJ | 1 |
| Lack, LC | 1 |
| Grunstein, RR | 1 |
| Lockley, SW | 1 |
| Rajaratnam, SM | 2 |
| Baker, EK | 1 |
| Richdale, AL | 1 |
| Hazi, A | 1 |
| Prendergast, LA | 1 |
| Nie, L | 1 |
| Wei, G | 1 |
| Peng, S | 1 |
| Qu, Z | 1 |
| Yang, Y | 1 |
| Yang, Q | 1 |
| Huang, X | 1 |
| Zhuang, Z | 1 |
| Yang, X | 1 |
| Chang, WP | 1 |
| Lin, CC | 1 |
| Rebai, R | 1 |
| Jasmin, L | 1 |
| Boudah, A | 1 |
| Berkiks, I | 1 |
| Benmhammed, H | 1 |
| Mesfioui, A | 1 |
| Ouichou, A | 1 |
| El Hasnaoui, A | 1 |
| Mouden, S | 1 |
| Touil, T | 1 |
| Bahbiti, Y | 1 |
| Nakache, R | 1 |
| El Hessni, A | 1 |
| Li, K | 1 |
| Shen, S | 1 |
| Ji, YT | 1 |
| Li, XY | 1 |
| Zhang, LS | 1 |
| Wang, XD | 1 |
| Højgaard, K | 2 |
| Christiansen, SL | 2 |
| Bouzinova, EV | 2 |
| Wiborg, O | 2 |
| Solís-Chagoyán, H | 2 |
| Dorantes-Barrón, AM | 2 |
| Quero-Chávez, D | 2 |
| Cruz-Garduño, R | 1 |
| Cercós, MG | 1 |
| Zhao, Y | 1 |
| Fu, Y | 1 |
| Ghaderi, A | 1 |
| Banafshe, HR | 1 |
| Mirhosseini, N | 1 |
| Motmaen, M | 1 |
| Mehrzad, F | 1 |
| Bahmani, F | 1 |
| Aghadavod, E | 1 |
| Mansournia, MA | 1 |
| Reiter, RJ | 1 |
| Karimi, MA | 1 |
| Asemi, Z | 1 |
| Moyanova, S | 2 |
| De Fusco, A | 1 |
| Santolini, I | 1 |
| Celli, R | 1 |
| Bucci, D | 1 |
| Mastroiacovo, F | 1 |
| Battaglia, G | 1 |
| Nicoletti, F | 1 |
| Tchekalarova, J | 2 |
| Arrieta-Baez, D | 1 |
| Taufique, SKT | 1 |
| Prabhat, A | 1 |
| Kumar, V | 1 |
| Zhang, J | 1 |
| Wang, Y | 3 |
| Xu, H | 1 |
| Yang, J | 1 |
| Stefanovic, B | 2 |
| Spasojevic, N | 2 |
| Jovanovic, P | 2 |
| Dronjak, S | 2 |
| Baroni, A | 1 |
| Petkova, Z | 1 |
| Pechlivanova, D | 1 |
| Kortenska, L | 1 |
| Mitreva, R | 1 |
| Lozanov, V | 1 |
| Atanasova, D | 1 |
| Lazarov, N | 1 |
| Stoynev, A | 1 |
| Del Fabbro, E | 1 |
| Dev, R | 1 |
| Hui, D | 1 |
| Palmer, L | 1 |
| Bruera, E | 1 |
| Norman, TR | 1 |
| Golan, D | 1 |
| Staun-Ram, E | 1 |
| Glass-Marmor, L | 1 |
| Lavi, I | 1 |
| Rozenberg, O | 1 |
| Dishon, S | 1 |
| Barak, M | 1 |
| Ish-Shalom, S | 1 |
| Miller, A | 1 |
| Tapia-Osorio, A | 1 |
| Salgado-Delgado, R | 1 |
| Angeles-Castellanos, M | 1 |
| Escobar, C | 1 |
| Haridas, S | 1 |
| Kumar, M | 1 |
| Manda, K | 1 |
| Obayashi, K | 2 |
| Saeki, K | 2 |
| Iwamoto, J | 2 |
| Ikada, Y | 1 |
| Kurumatani, N | 2 |
| Nowakowski, S | 2 |
| Kripke, DF | 6 |
| Elliott, J | 1 |
| Kartha, LB | 1 |
| Chandrashekar, L | 1 |
| Rajappa, M | 1 |
| Menon, V | 1 |
| Thappa, DM | 1 |
| Ananthanarayanan, PH | 1 |
| Ruksee, N | 1 |
| Tongjaroenbuangam, W | 1 |
| Mahanam, T | 1 |
| Govitrapong, P | 1 |
| Ramírez-Rodríguez, G | 2 |
| Gómez-Sánchez, A | 1 |
| Estrada-Camarena, E | 1 |
| Chen, WY | 1 |
| Giobbie-Hurder, A | 1 |
| Gantman, K | 1 |
| Savoie, J | 1 |
| Scheib, R | 1 |
| Parker, LM | 1 |
| Schernhammer, ES | 1 |
| Hansen, MV | 3 |
| Andersen, LT | 1 |
| Hageman, I | 2 |
| Rasmussen, LS | 1 |
| Bokmand, S | 1 |
| Rosenberg, J | 2 |
| Arushanian, ÉB | 2 |
| Huang, YL | 1 |
| Liang, XB | 1 |
| Qian, LQ | 1 |
| Cai, C | 2 |
| Guo, J | 1 |
| Gao, C | 1 |
| Guan, JH | 1 |
| Zhao, GP | 1 |
| Adamah-Biassi, EB | 1 |
| Hudson, RL | 1 |
| Danielsen, AK | 1 |
| Yao, HJ | 1 |
| Song, HT | 1 |
| Mo, YP | 1 |
| Zhang, TT | 1 |
| Han, XB | 1 |
| Li, ZG | 1 |
| Cubero-Millán, I | 1 |
| Molina-Carballo, A | 1 |
| Machado-Casas, I | 1 |
| Fernández-López, L | 1 |
| Martínez-Serrano, S | 1 |
| Tortosa-Pinto, P | 1 |
| Ruiz-López, A | 1 |
| Luna-del-Castillo, JD | 1 |
| Uberos, J | 1 |
| Muñoz-Hoyos, A | 1 |
| Li, S | 1 |
| Zhai, X | 1 |
| Rong, P | 1 |
| McCabe, MF | 1 |
| Zhao, J | 1 |
| Ben, H | 1 |
| Weiser, MJ | 1 |
| Wynalda, K | 1 |
| Salem, N | 1 |
| Butt, CM | 1 |
| Harb, F | 1 |
| Hidalgo, MP | 2 |
| Martau, B | 1 |
| Fu, W | 1 |
| Mokoena, ML | 1 |
| Harvey, BH | 1 |
| Viljoen, F | 1 |
| Ellis, SM | 1 |
| Brink, CB | 1 |
| Stefani, LC | 1 |
| Muller, S | 1 |
| Torres, IL | 1 |
| Razzolini, B | 1 |
| Rozisky, JR | 1 |
| Markus, R | 1 |
| Tone, N | 1 |
| Tanaka, K | 1 |
| Kataoka, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Double-blind Placebo-controlled Trial on Encapsulated Lemon Balm Efficacy and Tolerance on Sleep Quality Changes, and Mood and Wellbeing Effects Using Objective and Subjective Measures[NCT05422599] | 99 participants (Actual) | Interventional | 2022-05-05 | Completed | |||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| The Traditional Chinese Medicine Department of Xin Qiao Hospital[NCT02619266] | Phase 2/Phase 3 | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| A Randomized Clinical Trial of Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients[NCT00513357] | Phase 3 | 82 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054] | 50 participants (Anticipated) | Observational | 2017-03-15 | Enrolling by invitation | |||
| The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599] | Phase 2 | 86 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702] | 35 participants (Anticipated) | Observational | 2017-03-29 | Enrolling by invitation | |||
| Evaluation of Neurotoxic Effect of Sevoflurane-Based Anaesthesia Guided by Significant Short-Term Olfactory Identification Impairment in Old Age[NCT03726580] | 600 participants (Actual) | Observational [Patient Registry] | 2017-03-01 | Completed | |||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome[NCT02451293] | Phase 2/Phase 3 | 252 participants (Actual) | Interventional | 2016-01-18 | Completed | ||
| Light Therapy in Parkinson's Disease: a Prospective, Observational Study[NCT06129942] | 50 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | |||
| Dynamic Light Application to Prevent ICU Acquired Delirium[NCT01274819] | 1,000 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury[NCT02732288] | 1 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to Interrupted by Covid-19) | |||
| Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder[NCT00502320] | Phase 4 | 50 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| High Cortisol Levels as a Risk Factor for Depression in the Elderly and the Effect of Bright Light Treatment on Mood, Sleep-Wake Pattern and Self-Sufficiency[NCT00332670] | Phase 2/Phase 3 | 89 participants (Actual) | Interventional | 2003-01-31 | Terminated (stopped due to End of research time, time-resources) | ||
| [NCT00005401] | 0 participants | Observational | 1995-08-31 | Completed | |||
| Benefice Assessment of Repetitive Transcranial Magnetic Stimulation Used as an Additional Procedure to Rehabilitation Exercises in Patients Suffering From Fibromyalgia[NCT01308801] | 42 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029] | 220 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Difference in ESAS (Edmonton Symptom Assessment Scale) assessment scores of appetite (symptom) from baseline evaluation [± 3 days] to 4 week evaluation [± 3 days], where the severity at the time of assessment is rated from 0 to 10 on a numerical scale; with 0 meaning that the symptom is absent and 10 that it is the worst possible severity. (NCT00513357)
Timeframe: Baseline and at 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Melatonin | -0.83 |
| Placebo | -1.19 |
Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days
| Intervention | days (Median) |
|---|---|
| Morphine | 7 |
| Levobupivacaine | 7 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | mg/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 57.8 | 98.1 | 95 | 54.6 |
| Morphine | 57.2 | 106.2 | 118.5 | 66.9 |
"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery
| Intervention | score on a scale (Median) | |||||
|---|---|---|---|---|---|---|
| Before surgery | 24 h after surgery | 48 h after surgery | 72 h after surgery | 96 h after surgery | 120 h after surgery | |
| Levobupivacaine | 22 | 22 | 21 | 21 | 21 | 22 |
| Morphine | 21 | 20 | 20 | 20 | 20 | 20 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | g/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 4.5 | 4.7 | 5.2 | 5 |
| Morphine | 5.5 | 5.3 | 5.7 | 5.4 |
"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge
| Intervention | score on a scale (Median) | ||||||
|---|---|---|---|---|---|---|---|
| 3,6,9,12,15,18,21 and 24h after surgery | 27,30,33,36,39,42,45 and 48h after surgery | 51,54,57,60,63,66,69 and 72h after surgery | 4. postoperative day (every 8 hours) | 5. postoperative day (every 8 hours) | 6. postoperative day (every 8 hours) | Day of discharge | |
| Levobupivacaine | 0.6 | 0.5 | 0.5 | 0.3 | 0 | 0 | 0 |
| Morphine | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.3 | 1 |
Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery
| Intervention | pg/ml (Median) | ||
|---|---|---|---|
| Before surgery | 24h after surgery | 72h after surgery | |
| Levobupivacaine | 26.6 | 97.7 | 30.5 |
| Morphine | 27.2 | 104 | 50 |
Clinician-rated measure of mood; evaluates classical 21 Hamilton Depression items, and 8-item subscale measuring atypical depression symptoms which commonly occur during SAD episodes. Score ranges from 0-89, higher scores indicate higher levels of depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 19.99 | 15.97 | 19.47 | 20.65 | 23.68 |
| Ramelteon | 22.68 | 16.16 | 14.81 | 11.69 | 9.15 |
Self-rated scale to measure severity of depressive symptoms. Score ranges from 25-100, higher scores reflect more depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 58.63 | 56.40 | 58.59 | 58.62 | 61.65 |
| Ramelteon | 63.06 | 54.35 | 53.51 | 49.26 | 46.14 |
Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Score ranges from 0-21, higher scores represent more significant sleep disturbance. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 11.45 | 8.67 | 8.62 | 9.88 | 9.61 |
| Ramelteon | 11.56 | 9.52 | 7.57 | 8.07 | 7.05 |
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
46 reviews available for melatonin and Depression
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment.
Topics: Animals; Antidepressive Agents; Antioxidants; Benzofurans; Chronobiology Disorders; Cyclopropanes; D | 2022 |
Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression.
Topics: Animals; Brain; Depression; Humans; Immune System; Melatonin; Models, Biological; Neuroinflammatory | 2021 |
Night shift hormone: How does melatonin affect depression?
Topics: Animals; Antidepressive Agents; Depression; Humans; Inflammation; Melatonin; Serotonin | 2022 |
Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression.
Topics: Antidepressive Agents; Circadian Rhythm; Depression; Melatonin; Receptor, Melatonin, MT1; Receptor, | 2022 |
Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Aged; Brain-Derived Neurotrophic Factor; Depression; Dietary Supplements; Humans; Male; Melat | 2023 |
The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression.
Topics: Adolescent; Depression; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Feedback; Humans; Imm | 2023 |
Circadian insights into the biology of depression: Symptoms, treatments and animal models.
Topics: Animals; Biological Clocks; Circadian Rhythm; Depression; Depressive Disorder; Disease Models, Anima | 2019 |
Biological rhythms and chronotherapeutics in depression.
Topics: Animals; Chronotherapy; Circadian Rhythm; Cognitive Behavioral Therapy; Depression; Drug Chronothera | 2021 |
A practical nutritional guide for the management of sleep disturbances in menopause.
Topics: Adult; Aged; Anxiety; Depression; Diet; Female; Humans; Male; Melatonin; Menopause; Middle Aged; Obe | 2021 |
Circadian modulation of neuroplasticity by melatonin: a target in the treatment of depression.
Topics: Animals; Circadian Rhythm; Depression; Glutamic Acid; Hippocampus; Humans; Melatonin; Neuronal Plast | 2018 |
The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
Topics: Central Nervous System Depressants; Cholecystectomy, Laparoscopic; Depression; Dizziness; Headache D | 2019 |
[Melatonin as a drug: present status and perspectives].
Topics: Anti-Anxiety Agents; Antioxidants; Central Nervous System; Circadian Rhythm; Depression; Drug Admini | 2014 |
The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analysis.
Topics: Depression; Humans; Melatonin | 2014 |
Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions.
Topics: Adult; Antioxidants; Brain; Cerebral Palsy; Child; Cognition Disorders; Depression; Developmental Di | 2016 |
Chronotype and circadian rhythm in bipolar disorder: A systematic review.
Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Depression; Humans; Hydrocortisone; Mel | 2017 |
Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways.
Topics: Depression; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Intestines; Melato | 2016 |
Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin.
Topics: Animals; Depression; Gastrointestinal Microbiome; Humans; Melatonin; Multiple Sclerosis; Permeabilit | 2016 |
Pathophysiology of depression: role of sleep and the melatonergic system.
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Humans; Melatonin; Prevalence; Rece | 2009 |
[Depression as chronobiological illness].
Topics: Acetamides; Affect; Biological Clocks; Chronotherapy; Circadian Rhythm; Depression; Depressive Disor | 2009 |
Melatonin: pharmacological aspects and clinical trends.
Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Free Radical Scavengers; Humans; Indenes; | 2010 |
[Arterial hypertension and metabolic disorders].
Topics: Circadian Rhythm; CLOCK Proteins; Depression; Humans; Hypertension; Hypertrophy, Left Ventricular; K | 2010 |
[Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism].
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Drug Synergism | 2010 |
Melatonin and its analogs in insomnia and depression.
Topics: Acetamides; Animals; Depression; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Mice; Sleep In | 2012 |
The effects of agomelatine on sexual function in depressed patients and healthy volunteers.
Topics: Acetamides; Animals; Antidepressive Agents; Depression; Humans; Melatonin; Selective Serotonin Reupt | 2011 |
Emerging targets for the pharmacological treatment of depression: focus on melatonergic system.
Topics: Acetamides; Antidepressive Agents; Circadian Clocks; Depression; Humans; Indenes; Melatonin; Recepto | 2012 |
[Premenstrual dysphoric disorder: approach and treatment].
Topics: Affect; Anxiety; Depression; Female; Humans; Luteal Phase; Melatonin; Premenstrual Syndrome; Selecti | 2003 |
Circadian phase shifting, alerting, and antidepressant effects of bright light treatment.
Topics: Adaptation, Physiological; Adult; Bipolar Disorder; Circadian Rhythm; Depression; Eye Diseases; Fema | 2005 |
Therapeutic potential of melatonin ligands.
Topics: Animals; Antioxidants; Binding Sites; Depression; Humans; Ligands; Melatonin; Models, Chemical; NAD( | 2006 |
Melatonin: Nature's most versatile biological signal?
Topics: Animals; Antioxidants; Apoptosis; Chronobiology Phenomena; Depression; Free Radical Scavengers; Huma | 2006 |
Sleep and aging: 2. Management of sleep disorders in older people.
Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen | 2007 |
Menopause related sleep disorders.
Topics: Depression; Estrogen Replacement Therapy; Estrogens; Female; Fibromyalgia; Humans; Hydrocortisone; M | 2005 |
Light exposure, melatonin secretion, and menstrual cycle parameters: an integrative review.
Topics: Chronobiology Disorders; Circadian Rhythm; Clinical Nursing Research; Depression; Female; Follicle S | 2007 |
Circadian timing of sleepiness in man and woman.
Topics: Body Temperature; Central Nervous System; Circadian Rhythm; Depression; Female; Humans; Male; Melato | 1982 |
The circadian system and the therapeutics of the affective disorders.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior Therapy; Bipolar Disorder; Circadian | 1995 |
Melatonin supplements for aging.
Topics: Aged; Aging; Animals; Circadian Rhythm; Depression; Electromagnetic Fields; Feedback; Humans; Melato | 1996 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications.
Topics: Animals; Antidepressive Agents, Second-Generation; Biogenic Monoamines; Clinical Trials as Topic; De | 2001 |
Melatonin deficiencies in women.
Topics: Breast Neoplasms; Circadian Rhythm; Depression; Female; Humans; Jet Lag Syndrome; Melatonin; Menopau | 2002 |
Day-night rhythm disturbance, pineal function and human disease.
Topics: Animals; Anorexia Nervosa; Circadian Rhythm; Depression; Humans; Melatonin; Photoperiod; Pineal Glan | 1992 |
Seasonal affective disorder. Shedding light on a dark subject.
Topics: Circadian Rhythm; Depression; Humans; Melatonin; Phototherapy; Seasons | 1989 |
The pineal gland: anatomy, physiology, and clinical significance.
Topics: Analgesia; Animals; Brain Neoplasms; Circadian Rhythm; Depression; Electroencephalography; Humans; H | 1985 |
Monoamines, depression and antidepressant drugs.
Topics: Animals; Antidepressive Agents; Depression; Humans; Melatonin; Rats; Receptors, Adrenergic | 1988 |
Chronic exposure to ELF fields may induce depression.
Topics: Animals; Circadian Rhythm; Depression; Electromagnetic Fields; Electromagnetic Phenomena; Humans; Me | 1988 |
Disturbances of appetite and weight regulation in seasonal affective disorder.
Topics: Body Weight; Depression; Dietary Carbohydrates; Feeding and Eating Disorders; Feeding Behavior; Fema | 1987 |
Light therapy and psychiatry.
Topics: Atenolol; Circadian Rhythm; Depression; Depressive Disorder; Humans; Light; Melatonin; Mental Disord | 1986 |
21 trials available for melatonin and Depression
| Article | Year |
|---|---|
The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial.
Topics: Acute Coronary Syndrome; Aged; Antidepressive Agents; Anxiety; Depression; Depressive Disorder, Majo | 2019 |
Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Brain-Derived Neurotrophic Factor; Breast Neoplasms; | 2020 |
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD | 2019 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl | 2013 |
The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis.
Topics: Adult; Cholecalciferol; Data Interpretation, Statistical; Depression; Dietary Supplements; Female; H | 2013 |
A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes.
Topics: Adult; Affect; Aged; Aged, 80 and over; Breast Neoplasms; Depression; Double-Blind Method; Female; H | 2014 |
Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antidepressive Agents; Anxiety; Breast Neoplasms; Central Nervous System Depressants; D | 2014 |
Methylphenidate ameliorates depressive comorbidity in ADHD children without any modification on differences in serum melatonin concentration between ADHD subtypes.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2014 |
A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects.
Topics: Administration, Sublingual; Adult; Analgesics; Anxiety; Brazil; Depression; Dose-Response Relationsh | 2013 |
Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women.
Topics: Affect; Aged; Anxiety; Appetite; Body Mass Index; Depression; Double-Blind Method; Drug Therapy, Com | 2015 |
Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
Topics: Adult; Ambulatory Care; Depression; Female; Humans; Male; Melatonin; Saliva; Severity of Illness Ind | 2016 |
A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression: Study protocol and obstacle management.
Topics: Actigraphy; Adult; Circadian Rhythm; Depression; Depressive Disorder, Major; Hair; Humans; Hydrocort | 2017 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Aged, 80 and over; Anxiety; Behavioral Symptoms; Cross-Over Studies; Depression; Double-Blind | 2009 |
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome.
Topics: Adult; Central Nervous System Depressants; Circadian Rhythm; Cross-Over Studies; Depression; Double- | 2010 |
A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Cerebral Infarction; Depression; | 2012 |
[Complex estimation of the psychotropic activity spectrum of pineal hormone melatonin in young healthy humans].
Topics: Adult; Anxiety; Central Nervous System Depressants; Depression; Female; Humans; Male; Melatonin; Mem | 2012 |
Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine.
Topics: Adrenocorticotropic Hormone; Adult; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Bod | 2006 |
Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study.
Topics: Adult; Affect; Circadian Rhythm; Depression; Double-Blind Method; Female; Follicle Stimulating Hormo | 2001 |
Noradrenergic function and clinical outcome in antidepressant pharmacotherapy.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Depression; Fluvoxamine; Humans; Imipramine; Me | 2001 |
Negative effects of melatonin on depression.
Topics: Adult; Anger; Anxiety; Body Temperature; Body Weight; Calcium; Clinical Trials as Topic; Depression; | 1976 |
130 other studies available for melatonin and Depression
| Article | Year |
|---|---|
Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice.
Topics: Animals; Antidepressive Agents; Depression; Drug Combinations; Drug Synergism; Ketamine; Male; Melat | 2021 |
Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats.
Topics: Animals; Brain Injuries, Traumatic; Cyclic AMP Response Element-Binding Protein; Depression; Heme Ox | 2022 |
Gene expression profile associated with Asmt knockout-induced depression-like behaviors and exercise effects in mouse hypothalamus.
Topics: Acetylserotonin O-Methyltransferase; Animals; Depression; Hypothalamus; Melatonin; Mice; Transcripto | 2022 |
Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats.
Topics: Animals; Depression; Hippocampus; Melatonin; Neuronal Plasticity; Pineal Gland; Rats; Sleep Deprivat | 2022 |
Behavioral and Fluorescent-Based Immunohistochemistry Protocols for Examining Antidepressant-Like Effects of Melatonin in Mice.
Topics: Animals; Antidepressive Agents; Depression; Hippocampus; Immunohistochemistry; Melatonin; Mice; Neur | 2022 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative S | 2023 |
Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia.
Topics: Anxiety; COVID-19; Depression; Humans; Melatonin; Sleep Initiation and Maintenance Disorders | 2023 |
Repeated donkey milk consumption reduces anxiety-like behaviors and brain oxidative damage to lipids in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Brain Injuries; Depression; Lipids; | 2023 |
Sleep-light interventions that shift melatonin rhythms earlier improve perimenopausal and postmenopausal depression: preliminary findings.
Topics: Circadian Rhythm; Depression; Female; Humans; Melatonin; Perimenopause; Postmenopause; Sleep | 2023 |
Melatonin Prevents Depression but Not Anxiety-like Behavior Produced by the Chemotherapeutic Agent Temozolomide: Implication of Doublecortin Cells and Hilar Oligodendrocytes.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Depression; Doublecortin Domain Proteins; Mel | 2023 |
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; Cognitive Dysfunction; Depression; Melatonin | 2023 |
Melatonin reverses depressive and anxiety like-behaviours induced by diabetes: involvement of oxidative stress, age, rage and S100B levels in the hippocampus and prefrontal cortex of rats.
Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Hippocampus; Malondialdehyde; Melaton | 2022 |
Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice.
Topics: Animals; Antidepressive Agents; Dendrites; Dentate Gyrus; Depression; Doublecortin Domain Proteins; | 2020 |
Adolescent social anxiety and clock disruption. A commentary.
Topics: Adolescent; Anxiety; Circadian Rhythm; Depression; Humans; Melatonin; Sleep | 2020 |
Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study.
Topics: Actigraphy; Aged; Case-Control Studies; Circadian Rhythm; Depression; Female; Humans; Male; Melatoni | 2020 |
Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress.
Topics: Animals; Chemokine CX3CL1; Depression; Hippocampus; Male; Melatonin; Mice; Mice, Inbred BALB C; Micr | 2020 |
Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus.
Topics: Animals; Behavior, Animal; Depression; Endoplasmic Reticulum Stress; Hippocampus; Male; Melatonin; R | 2021 |
Increased spindle density correlates with sleep continuity improvements following an eight-week course of a melatonin agonist in people with depression: A proof-of-concept study with agomelatine.
Topics: Acetamides; Adolescent; Adult; Depression; Humans; Melatonin; Sleep; Young Adult | 2021 |
Evaluation of salivary melatonin concentrations as a circadian phase maker of morning awakening and their association with depressive mood in postpartum mothers.
Topics: Circadian Rhythm; Depression; Female; Humans; Melatonin; Mothers; Postpartum Period; Sleep | 2021 |
Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder.
Topics: Adolescent; Adult; Affect; Circadian Rhythm; Depression; Female; Humans; Light; Male; Melatonin; Mid | 2017 |
Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability.
Topics: Adult; Anxiety; Autism Spectrum Disorder; Circadian Rhythm; Depression; Female; Humans; Male; Melato | 2017 |
Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anxiety; Depression; Disease Models, Animal; Glutathione Transferase; Hi | 2017 |
Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; Depression; Fatigue; Female; | 2017 |
The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices.
Topics: Animals; Antidepressive Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Fluoxetine; Gl | 2017 |
Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Anxiety; Behavior, Animal; Depression; Lipopolysacc | 2018 |
Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF-TrkB Signaling.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dru | 2018 |
Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment.
Topics: Acetamides; Animals; Antidepressive Agents; Circadian Rhythm; CLOCK Proteins; Depression; Disease Mo | 2018 |
[Effects of chronic stress depression on the circadian rhythm of peripheral neuroendocrine hormone of rats].
Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Male; Melatonin; Random Allocation; Rats; Rat | 2017 |
Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?
Topics: Animals; Behavior Rating Scale; Depression; Disease Models, Animal; Epilepsy, Absence; Hippocampus; | 2018 |
The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hindlimb Suspension; Male; Melat | 2018 |
Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids.
Topics: Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Crows; Dep | 2018 |
Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.
Topics: Adrenal Glands; Animals; Catecholamines; Chronic Disease; Depression; Disease Models, Animal; Gene E | 2019 |
Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder?
Topics: Adolescent; Antioxidants; Anxiety; Chronotherapy; Circadian Rhythm; Combined Modality Therapy; Depre | 2019 |
Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Central Nervous System Depressants; Chromatography, High Pressure Liq | 2013 |
Agomelatine, melatonin and depressive disorder.
Topics: Acetamides; Animals; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Human | 2013 |
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat.
Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste | 2013 |
Melatonin ameliorates chronic mild stress induced behavioral dysfunctions in mice.
Topics: Animals; Central Nervous System Depressants; Depression; Eating; Immobility Response, Tonic; Male; M | 2013 |
Exposure to light at night and risk of depression in the elderly.
Topics: Aged; Circadian Rhythm; Cross-Sectional Studies; Depression; Female; Humans; Light; Male; Melatonin; | 2013 |
Antepartum depression severity is increased during seasonally longer nights: relationship to melatonin and cortisol timing and quantity.
Topics: Adult; Affect; Area Under Curve; Circadian Rhythm; Cross-Sectional Studies; Darkness; Depression; Fe | 2013 |
Serum melatonin levels in psoriasis and associated depressive symptoms.
Topics: Depression; Female; Humans; Male; Melatonin; Psoriasis | 2014 |
Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Blotting, Western; Cell Proliferation; Cells, C | 2014 |
Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Antioxidants; Behavior, Animal; Citalopram; Depre | 2014 |
Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression.
Topics: Animals; Brain; Depression; Disease Models, Animal; Drinking Behavior; Drugs, Chinese Herbal; Gene E | 2015 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice.
Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Depression; Female; Male; Melatonin; Mice; Mic | 2014 |
[Effects of electroacupuncture on circadian rhythm of temperature and melatonin in depression rats model induced by chronic stress].
Topics: Animals; Circadian Rhythm; Depression; Electroacupuncture; Humans; Male; Melatonin; Rats; Rats, Spra | 2014 |
Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in Zucker diabetic fatty rats.
Topics: Animals; Depression; Diabetes Complications; Male; Melatonin; Rats; Rats, Zucker; Transcutaneous Ele | 2014 |
Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats.
Topics: Animals; Behavior, Animal; Biomarkers; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Depres | 2015 |
Lack of exposure to natural light in the workspace is associated with physiological, sleep and depressive symptoms.
Topics: Adult; Aged; Circadian Rhythm; Cross-Sectional Studies; Depression; Female; Humans; Light; Male; Mel | 2015 |
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder, Major | 2015 |
Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort.
Topics: Aged; Aged, 80 and over; Cognition; Cohort Studies; Cross-Sectional Studies; Depression; Female; Ger | 2015 |
[LIGHT POLLUTION AS THE HYGIENIC PROBLEM].
Topics: Depression; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Humans; Light | 2015 |
Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression.
Topics: Anhedonia; Animals; Biomarkers; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Eati | 2016 |
Effects of environmental stress on the depression-like behaviors and the diurnal rhythm of corticosterone and melatonin in male rats.
Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Depressive Disorde | 2016 |
Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity.
Topics: Adult; Brain; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Female; Humans; Ma | 2016 |
Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels.
Topics: Animals; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Dopamine beta-Hydroxylase; | 2016 |
Agomelatine and Transient Elevation of Creatine Phosphokinase.
Topics: Acetamides; Adult; Antidepressive Agents; Creatine Kinase; Depression; Humans; Liver; Liver Function | 2016 |
Biomolecular aspects of depression: A retrospective analysis.
Topics: Adult; Biomarkers; Case-Control Studies; Catecholamines; Cytokines; Depression; Female; Humans; Hydr | 2017 |
Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Depression; Disease Models, Animal; M | 2017 |
The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.
Topics: Acute Coronary Syndrome; Anxiety; Circadian Rhythm; Clinical Protocols; Depression; Double-Blind Met | 2017 |
We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections.
Topics: Aggression; Animals; Anxiety; Body Weight; Data Interpretation, Statistical; Depression; Food Prefer | 2009 |
Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Depression; Male; Melatonin; Mic | 2008 |
[Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile].
Topics: Affect; Aged; Aged, 80 and over; Cognition; Dementia; Depression; Female; Humans; Male; Melatonin; P | 2008 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Melatonin modulates cell survival of new neurons in the hippocampus of adult mice.
Topics: Adult Stem Cells; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; | 2009 |
Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule.
Topics: Affect; Analysis of Variance; Animals; Anxiety; Circadian Rhythm; Depression; Disease Models, Animal | 2009 |
Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors.
Topics: Adolescent; Adult; Circadian Rhythm; Depression; Enzyme-Linked Immunosorbent Assay; Female; Humans; | 2010 |
Agomelatine: new drug. Adverse effects and no proven efficacy.
Topics: Acetamides; Animals; Antidepressive Agents; Bias; Carcinogens; Clinical Trials as Topic; Cyclohexano | 2009 |
The role of environmental light in sleep and health: effects of ocular aging and cataract surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cataract Extraction; Child; Circadian | 2010 |
N-acetylserotonin activates TrkB receptor in a circadian rhythm.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cell Line; Circadian Rhythm; Depr | 2010 |
[Clinical experiences with agomelatine. The inner ear has to be synchronized again].
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Controlled Clinical Trials as Topic; Depression | 2010 |
Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression.
Topics: Adult; Body Temperature; Circadian Rhythm; Depression; Female; Humans; Male; Melatonin; Middle Aged; | 2010 |
Sleep disturbance and melatonin levels following traumatic brain injury.
Topics: Adult; Anxiety; Area Under Curve; Brain Injuries; Case-Control Studies; Depression; Electroencephalo | 2010 |
Relationship of morningness-eveningness questionnaire score to melatonin and sleep timing, body mass index and atypical depressive symptoms in peri- and post-menopausal women.
Topics: Analysis of Variance; Body Mass Index; Circadian Rhythm; Depression; Female; Humans; Melatonin; Meno | 2011 |
Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children.
Topics: Case-Control Studies; Child; Depression; Female; Humans; Hydrocortisone; Male; Melatonin; Saliva; Te | 2011 |
A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Circadian Clocks; Combined Modality Therapy; D | 2012 |
[Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model].
Topics: Acetylserotonin O-Methyltransferase; Animals; Arylalkylamine N-Acetyltransferase; Depression; Diseas | 2012 |
Does the pineal gland have a role in the psychological mechanisms involved in the progression of cancer?
Topics: Amygdala; Animals; Autonomic Nervous System; Depression; Disease Progression; Emotions; Hormones; Hu | 2002 |
Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers.
Topics: Aged; Circadian Rhythm; Depression; Female; Humans; Light; Male; Melatonin; Middle Aged; Phototherap | 2002 |
Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Drug Combinations; Dru | 2003 |
Highlights and abstracts of the fifteenth annual Society for Light Treatment and Biological Rhythms virtual meeting 2003.
Topics: Biological Clocks; Circadian Rhythm; Clinical Trials as Topic; Depression; Humans; Melatonin; Photot | 2003 |
Naps and circadian rhythms in postmenopausal women.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Depression; Female; Humans; Interview, Psychological; Mel | 2004 |
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model.
Topics: Acetamides; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticost | 2005 |
Overdoing the late-night nosh. Some people get into an unhealthy pattern of nighttime eating. Depression or hormonal imbalances may be to blame.
Topics: Depression; Feeding and Eating Disorders; Feeding Behavior; Humans; Melatonin; Syndrome; Time Factor | 2005 |
The pattern of melatonin receptor expression in the brain may influence antidepressant treatment.
Topics: Antidepressive Agents; Brain; Depression; Gene Expression; Humans; Melatonin; Models, Neurological; | 2007 |
Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls.
Topics: Adult; Anxiety; Breast Neoplasms; Catecholamines; Depression; Female; Health Status; Humans; Hydroco | 2007 |
Plasma melatonin and antidepressant drugs.
Topics: Antidepressive Agents; Circadian Rhythm; Depression; Humans; Melatonin | 1980 |
Melatonin and cortisol levels in psychiatric illness.
Topics: Depression; Diagnosis, Differential; Humans; Hydrocortisone; Melatonin; Mental Disorders; Schizophre | 1982 |
Down-regulation at pineal beta-adrenoceptors in depressed patients treated with desipramine?
Topics: Animals; Depression; Desipramine; Humans; Melatonin; Pineal Gland; Receptors, Adrenergic; Receptors, | 1983 |
How information processing mode could affect prostaglandin E1 metabolism and lung inactivation: relevance of hemispheric specialization, neurotransmitter asymmetry and brain reactivity.
Topics: Alprostadil; beta-Endorphin; Brain; Cognition; Depression; Endorphins; Humans; Lung; Melatonin; Mode | 1984 |
Critical interval hypotheses for depression.
Topics: Animals; Antidepressive Agents; Circadian Rhythm; Cricetinae; Depression; Humans; Light; Melatonin; | 1984 |
[Medical topics: melatonin/cortisol ratio].
Topics: Depression; Humans; Hydrocortisone; Melatonin | 1982 |
An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives.
Topics: Adolescent; Adult; Aged; Depression; Depressive Disorder; Desipramine; Female; Humans; Male; Melaton | 1981 |
The 24 hour pattern of plasma melatonin in depressed patients before and after treatment.
Topics: Adult; Amitriptyline; Depression; Female; Humans; Melatonin; Middle Aged; Psychiatric Status Rating | 1980 |
Serum melatonin and 6-sulfatoxymelatonin in end-stage renal disease: effect of hemodialysis.
Topics: Adult; Creatinine; Depression; Female; Humans; Kidney Failure, Chronic; Male; Melatonin; Middle Aged | 1993 |
The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa.
Topics: Adolescent; Adult; Aging; Anorexia Nervosa; Circadian Rhythm; Depression; Female; Humans; Melatonin; | 1993 |
[Antidepressants, melatonin and seasonal depression].
Topics: Appetite; Depression; Humans; Melatonin; Phototherapy | 1994 |
Light and magnetic fields in a neonatal intensive care unit.
Topics: Breast Neoplasms; Circadian Rhythm; Depression; Electromagnetic Fields; Equipment and Supplies, Hosp | 1996 |
Psychobiology of premenstrual dysphoric disorder.
Topics: Adult; beta-Endorphin; Depression; Female; Humans; Melatonin; Menstrual Cycle; Neurosecretory System | 1997 |
Melatonin excretion is not related to sleep in the elderly.
Topics: Aged; Circadian Rhythm; Depression; Humans; Melatonin; Middle Aged; Monitoring, Physiologic; Polysom | 1998 |
Testing the hypothesis of a circadian phase disturbance underlying depressive mood in nonseasonal depression.
Topics: Adult; Affect; Analysis of Variance; Body Temperature; Circadian Rhythm; Depression; Electroencephal | 1998 |
Melatonin: marvel or marker?
Topics: Adult; Aged; Aged, 80 and over; Aging; Case-Control Studies; Circadian Rhythm; Depression; Female; H | 1998 |
Depression or cancer: the choice between serotonin or melatonin?
Topics: Depression; Depressive Disorder; Humans; Hypothalamo-Hypophyseal System; Melatonin; Models, Biologic | 1998 |
Plasma melatonin and cortisol in patients with obsessive-compulsive disorder: relationship with axillary temperature, physical activity, and clinical symptoms.
Topics: Adult; Analysis of Variance; Area Under Curve; Behavioral Symptoms; Body Temperature; Case-Control S | 1998 |
[Melatonin: myth or reality?].
Topics: Adjuvants, Immunologic; Adult; Animals; Antioxidants; Cattle; Child; Contraindications; Controlled C | 1998 |
Melatonin in postmenopausal females.
Topics: Depression; Female; Humans; Hyperprolactinemia; Melatonin; Middle Aged; Obesity; Postmenopause; Refe | 2000 |
Exposure to electromagnetic fields and suicide among electric utility workers: a nested case-control study.
Topics: Adult; Case-Control Studies; Cohort Studies; Confounding Factors, Epidemiologic; Depression; Electro | 2000 |
Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin.
Topics: Animals; Antioxidants; Behavior, Animal; Depression; Female; Fluoxetine; Male; Melatonin; Motor Acti | 2000 |
Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation.
Topics: Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Antioxidants; Benzodiazepinones; Bic | 2000 |
Acute antidepressant-like and antianxiety-like effects of tryptophan in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Dose-Res | 2001 |
Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment.
Topics: Adult; Affect; Antidepressive Agents; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Ma | 2001 |
Hypothalamic involvement in chronic migraine.
Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Chronobiology Disorders; Circadian Rhythm; Co | 2001 |
Urinary melatonin rhythms during sleep deprivation in depressed patients and normals.
Topics: Adult; Aged; Circadian Rhythm; Depression; Electroencephalography; Female; Humans; Lighting; Male; M | 1977 |
Coexisting bipolar affective disorder and multiple sclerosis: the role of the pineal gland.
Topics: Autoimmune Diseases; Bipolar Disorder; Circadian Rhythm; Depression; Humans; Immune Tolerance; Light | 1991 |
Tardive dyskinesia associated with depression in a bipolar patient: possible role of melatonin.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Depression; Dyskinesia, Drug-Induced; Humans; Male; M | 1990 |
[Winter depression and light therapy].
Topics: Depression; Humans; Melatonin; Phototherapy; Seasons | 1991 |
Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin.
Topics: Adult; Depression; Dyskinesia, Drug-Induced; Female; Humans; Melatonin; Psoriasis; Psychotic Disorde | 1990 |
Pineal melatonin functions and the depression of Parkinson's disease: a hypothesis.
Topics: 5-Hydroxytryptophan; Animals; Depression; Dopamine; Humans; Melatonin; Models, Neurological; Parkins | 1990 |
[Current therapeutic approaches from chronobiology: light and melatonin].
Topics: Circadian Rhythm; Depression; Humans; Light; Melatonin; Seasons; Work Schedule Tolerance | 1990 |
[Phototherapy in depression].
Topics: Depression; Female; Humans; Melatonin; Phototherapy; Recurrence; Seasons | 1990 |
The relationship of serotonin metabolism and melatonin secretion to the pathophysiology of tardive dyskinesia.
Topics: Animals; Depression; Dyskinesia, Drug-Induced; Humans; Melatonin; Risk Factors; Serotonin | 1989 |
The dim light melatonin onset as a marker for circadian phase position.
Topics: Animals; Biomarkers; Circadian Rhythm; Depression; Humans; Hydrocortisone; Light; Melatonin; Seasons | 1989 |
How antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of antidepressant drug treatment.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents; Brain; Catecholamines; Depression; Fenfluramine; | 1986 |
Neuroendocrine and other studies of the mechanism of antidepressant action of desipramine.
Topics: Animals; Blood Pressure; Clonidine; Depression; Desipramine; Growth Hormone; Humans; Melatonin; Phen | 1986 |
Characteristic changes in psychiatric symptoms, cortisol and melatonin but not prolactin in primary hyperparathyroidism.
Topics: Adenoma; Adult; Aged; Circadian Rhythm; Depression; Goiter; Humans; Hydrocortisone; Hyperparathyroid | 1988 |
Patterns of melatonin rhythms in depression.
Topics: Adult; Circadian Rhythm; Depression; Depressive Disorder; Desipramine; Female; Humans; Isoproterenol | 1986 |
Circadian characteristics of urinary melatonin from clinically healthy young women at different civilization disease risks.
Topics: Adolescent; Adult; Breast Neoplasms; Cardiovascular Diseases; Circadian Rhythm; Depression; Female; | 1986 |
Antidepressant and circadian phase-shifting effects of light.
Topics: Circadian Rhythm; Depression; Humans; Light; Melatonin | 1987 |
Melatonin, light and chronobiological disorders.
Topics: Circadian Rhythm; Darkness; Depression; Disease; Humans; Light; Melatonin; Periodicity; Phototherapy | 1985 |
Melatonin and affective disorders.
Topics: Cluster Headache; Darkness; Depression; Humans; Hypothalamo-Hypophyseal System; Light; Melatonin; Mo | 1985 |