Page last updated: 2024-10-19

melatonin and Depression, Postpartum

melatonin has been researched along with Depression, Postpartum in 9 studies

Depression, Postpartum: Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's3 (33.33)2.80

Authors

AuthorsStudies
Slyepchenko, A1
Minuzzi, L1
Reilly, JP1
Frey, BN1
Parry, BL4
Meliska, CJ3
Sorenson, DL3
Martinez, LF2
Lopez, AM2
Dawes, SE1
Elliott, JA1
Hauger, RL2
Obeysekare, JL1
Cohen, ZL1
Coles, ME1
Pearlstein, TB1
Monzon, C1
Flynn, EE1
Sharkey, KM1
Swanson, LM1
Burgess, HJ1
Zollars, J1
Todd Arnedt, J1
Orff, HJ1
Kripke, DF1
Anderson, G1
Kim, DR1
Czarkowski, KA1
Epperson, CN1
Basavaraj, N1
Zirpoli, GG1
Gamst, A1
Hauger, R1
Newton, RP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Light Therapy on Circadian Rhythms, Sleep, and Mood in Postpartum Depression[NCT02769858]10 participants (Actual)Interventional2015-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline Time of Dim Light Melatonin Onset (DLMO) at 5 Weeks

Onset of melatonin in dim light conditions as measured in saliva (also called DLMO) Time of DLMO is measured in clock time, so a positive number in change would represent a later onset of melatonin and a negative number represents an earlier onset of melatonin (NCT02769858)
Timeframe: After five weeks of light therapy

Interventionminutes (Mean)
Light Therapy-6

Change From Baseline Score of the Edinburgh Postnatal Depression Scale (EPDS) at 5 Weeks

Self-report of depression symptoms. The Edinburgh Postnatal Depression scale is scored from 0 to 30 where 0 is no depression and 30 is most severe depression. (NCT02769858)
Timeframe: After five weeks of light therapy

InterventionEPDS score (Mean)
Pre-Treatment (EPDSPost-Treatment (EPDS)
Light Therapy12.757.75

Change From Baseline Score of the Hamilton Depression Rating Scale-Seasonal Affective Version (SIGH-SAD) at 5 Weeks

Clinician-rated depression symptom severity measure; Hamilton Depression Rating Scale-Seasonal Affective Version (SIGH-SAD) (29 item version) measures depressive symptoms on a continuous scale. Higher scores indicate worse outcomes. Scores can range from 0 -73, where 0 means no depression, and 73 is the greatest possible depression. Generally scores of 20 or higher represent clinical depression (NCT02769858)
Timeframe: After five weeks of light therapy

InterventionSIGH-SAD score (Mean)
Pre-treatmentPost-treatment
Light Therapy24.7512.88

Reviews

2 reviews available for melatonin and Depression, Postpartum

ArticleYear
The relationship between bipolar disorder, seasonality, and premenstrual symptoms.
    Current psychiatry reports, 2011, Volume: 13, Issue:6

    Topics: Bipolar Disorder; Depression, Postpartum; Female; Humans; Melatonin; Premenstrual Syndrome; Seasonal

2011
Chronobiological basis of female-specific mood disorders.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:5 Suppl

    Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P

2001

Trials

3 trials available for melatonin and Depression, Postpartum

ArticleYear
Critically-timed sleep+light interventions differentially improve mood in pregnancy vs. postpartum depression by shifting melatonin rhythms.
    Journal of affective disorders, 2023, 03-01, Volume: 324

    Topics: Affect; Circadian Rhythm; Depression, Postpartum; Female; Humans; Melatonin; Pregnancy; Sleep

2023
Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances.
    Journal of affective disorders, 2019, 02-15, Volume: 245

    Topics: Adult; Affect; Circadian Rhythm; Depression, Postpartum; Depressive Disorder, Major; Female; Humans;

2019
Chronobiological basis of female-specific mood disorders.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:5 Suppl

    Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P

2001

Other Studies

5 other studies available for melatonin and Depression, Postpartum

ArticleYear
Longitudinal Changes in Sleep, Biological Rhythms, and Light Exposure From Late Pregnancy to Postpartum and Their Impact on Peripartum Mood and Anxiety.
    The Journal of clinical psychiatry, 2022, 01-18, Volume: 83, Issue:2

    Topics: Actigraphy; Adult; Affect; Anxiety; Circadian Rhythm; Depression, Postpartum; Female; Humans; Longit

2022
Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression.
    Translational psychiatry, 2020, 01-21, Volume: 10, Issue:1

    Topics: Actigraphy; Circadian Rhythm; Depression, Postpartum; Female; Humans; Melatonin; Pregnancy; Sleep

2020
An open-label pilot study of a home wearable light therapy device for postpartum depression.
    Archives of women's mental health, 2018, Volume: 21, Issue:5

    Topics: Adult; Circadian Rhythm; Depression, Postpartum; Feasibility Studies; Female; Humans; Melatonin; Pho

2018
The role of melatonin in post-partum psychosis and depression associated with bipolar disorder.
    Journal of perinatal medicine, 2010, Volume: 38, Issue:6

    Topics: Animals; Bipolar Disorder; Depression, Postpartum; Female; Humans; Melatonin; Models, Animal; Pregna

2010
Hormonal basis of mood and postpartum disorders.
    Current women's health reports, 2003, Volume: 3, Issue:3

    Topics: Adult; Case-Control Studies; Depression, Postpartum; Estrogens; Female; Hormones; Humans; Hydrocorti

2003