Page last updated: 2024-10-19

melatonin and Delirium

melatonin has been researched along with Delirium in 97 studies

Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)

Research Excerpts

ExcerptRelevanceReference
" There was no significant difference in the average proportion of delirium-free assessments per patient between the melatonin and placebo groups (79."9.51Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial. ( Anstey, M; Chapman, A; Ford, A; Hawkins, D; Ho, KM; Kelty, E; Litton, E; Martinez, FE; McCaffrey, J; Murray, K; Myers, E; Rashid, A; Regli, A; van Haren, FMP; Wibrow, B; Wyer, S, 2022)
"The current study (clinical trial registered number: CHWX-904-201511) suggests that acute melatonin treatment can reduce the incidence of delirium for elderly acute heart failure."9.51Effects of Melatonin for Delirium in Elderly Acute Heart Failure Patients: A Randomized, Single-Center, Double-Blind, and Placebo-Controlled Trial. ( Gu, L; Liu, X; Wan, R; Ye, T; Yin, B; Zong, G, 2022)
"Experimental evidence has indicated the benefits of melatonin (Mel) for the treatment of delirium."9.41Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial. ( Shi, Y, 2021)
"Although ramelteon has been examined as a relatively new therapeutic option for delirium prevention, current evidence to evaluate its efficacy is limited."9.41Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials. ( Carvalho, AF; Chang, CH; Hsu, CW; Hsu, TW; Liang, CS; Thompson, T; Tsai, TC; Tseng, PT; Tu, YK; Yang, FC; Yang, SN; Yu, CL, 2023)
"To assess the efficacy of melatonin and melatonergic agonist for the treatment of delirium in hospitalized patients."9.41Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis. ( Beaucage-Charron, J; Coveney, R; Rinfret, J; Williamson, D, 2023)
"To determine the preventive effect of melatonin on delirium in the intensive care units."9.41Melatonin intervention to prevent delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Bao, Q; Duan, Y; Shao, J; Wan, L; Wan, X; Wang, G; Yang, Y; Yue, J; Zhu, W, 2023)
"To determine the feasibility of a trial of oral melatonin 5 mg nightly for five nights for the treatment of delirium in older medical inpatients, and determine the participants required to demonstrate a clinically and statistically significant decrease in severity of delirium in older medical inpatients treated with melatonin."9.41Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients. ( Clayton-Chubb, DI; Lange, PW; Maier, AB; Watson, R, 2021)
"The 'Prophylactic Melatonin for Delirium in Intensive Care' study is a multi-centre, randomised, double-blinded, placebo-controlled trial."9.41Statistical analysis plan for the Prophylactic Melatonin for Delirium in Intensive Care (ProMEDIC): a randomised controlled trial. ( Anstey, M; Ford, A; Ho, KM; Kelty, E; Litton, E; Martinez, FE; Murray, K; Myers, E; Wibrow, B, 2021)
"Melatonin may be effective in reducing the severity of delirium after cardiac surgery."9.41Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. ( Janatmakan, F; Javaherforoosh Zadeh, F; Jorairahmadi, S; Shafaeebejestan, E, 2021)
" Forty-two participants developed delirium, but it was evenly distributed between the groups (melatonin 21/98, 21."9.34The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Kelly, R; Passage, J; Patel, H; Wibrow, B, 2020)
"The Basel BOMP-AID study is an investigator-initiated, single-centre, randomised controlled clinical trial for the treatment of hypoactive delirium with the once daily oral administration of melatonin 4 mg versus placebo in 190 critically ill patients."9.34Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID s ( Abdelhamid, S; Cajochen, C; Gebhard, CE; Hollinger, A; Huber, J; Reinhold, S; Siegemund, M; Steiner, LA; Sutter, R; Todorov, A; Tran, F; von Felten, S, 2020)
" The respective melatonin (n = 30) vs placebo (n = 30) outcomes were: incident delirium in 11/30 (36."9.34Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial. ( Agar, M; Bush, SH; Currow, DC; Dasgupta, M; Lacaze-Masmonteil, N; Lawlor, PG; MacDonald, AR; McNamara-Kilian, MT; Momoli, F; Pereira, JL; Tierney, S, 2020)
"In this randomized control trial, a total of 59 AOPP patients with subsequent delirium were randomly divided into two groups, the melatonin group (n=29) and the placebo-controlled group (n=30)."9.27Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients. ( Du, GH; Li, ZF; Pan, YY; Zhang, Y; Zhao, LB; Zhen, GD; Zhou, SZ, 2018)
"Studies suggest that melatonin may prevent delirium, a condition of acute brain dysfunction occurring in 20%-30% of hospitalized older adults that is associated with increased morbidity and mortality."9.27Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial. ( Garcia, S; Jaiswal, SJ; Kang, DY; Loeks, M; Lu, CY; McCarthy, TJ; Owens, RL; Song, J; van Niekerk, CJ; Wineinger, NE, 2018)
"Although a previous review illustrated the efficacy of melatonin receptor agonists (MRAs) in preventing delirium, some recent randomized controlled trials (RCTs) did not confirm these effects."9.22Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Kawilapat, S; Kongsaengdao, S; Likhitsathian, S; Maneeton, B; Maneeton, N; Srisurapanont, M; Woottiluk, P, 2022)
"Studies on melatonin and melatonergic agents (MMA) for the prevention of postoperative delirium (POD) have produced inconsistent findings."9.22Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials. ( Wang, CM; Zhou, LY, 2022)
"The Healthy Heart-Mind trial is a randomized, double-blind, placebo-controlled clinical trial of 3 mg melatonin or matching placebo administered on seven consecutive days for the prevention of delirium following cardiac surgery."9.22The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Passage, J; Wibrow, B, 2016)
" Patients with or without delirium (as assessed using the Confusion Assessment Method for the ICU) were compared in terms of baseline characteristics and outcomes and the circadian rhythm of melatonin excretion using the 24-h excretion of its urinary metabolite 6-sulfatoxymelatonin (aMT6s)."9.20Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial. ( Brochard, L; Brun-Buisson, C; Charles-Nelson, A; Dessap, AM; Katsahian, S; Launay, JM; Roche-Campo, F, 2015)
"To determine whether the postoperative administration of tryptophan would be beneficial for elderly adults undergoing surgery who are at risk of developing postoperative delirium."9.19Tryptophan supplementation and postoperative delirium--a randomized controlled trial. ( Adams, JC; Dunn, CL; Hawkins, CL; Moss, M; Raeburn, CD; Robinson, TN; Tran, ZV, 2014)
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium."9.19Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014)
", melatonin) may have a role in the pathogenesis of delirium."9.15Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. ( Al-Aama, T; Brymer, C; Dasgupta, M; Esbaugh, J; Gutmanis, I; Woolmore-Goodwin, SM, 2011)
"Melatonin, a pineal gland hormone is reported to have a protective effect against delirium."9.12Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis. ( Khaing, K; Nair, BR, 2021)
" We reviewed the literature on the role of melatonin and ramelteon in the prevention of sleep disturbances and delirium in intensive care units and analysed the methods of melatonin therapy in an ICU setting."9.05The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review. ( Cubała, WJ; Lewandowska, K; Małkiewicz, MA; Mędrzycka-Dąbrowska, WA; Siemiński, M; Winklewski, PJ, 2020)
" Incidence of delirium was not significantly lower in patients who received melatonin, with an odd ratio, OR (95%Cl) of 0."9.05The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. ( Khor, AJ; Ng, KT; Teoh, WY, 2020)
" Studies reporting outcomes for melatonin or ramelteon use to prevent delirium in postoperative hospitalized patients (mean age ≥ 50 years) were eligible for inclusion."9.01Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis. ( Axon, DR; Campbell, AM; Lee, JK; Martin, JR; Mollon, L; Slack, MK, 2019)
"To investigate the efficacy of exogenous administration of melatonin and melatonin receptor agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in the intensive care unit (ICU)."9.01Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Gao, F; Li, Z; Sun, W; Zhang, Q; Zhang, S, 2019)
"To review the prospective controlled trials available for the use of melatonin receptor agonists for delirium prevention."8.95Melatonin Receptor Agonists for Delirium Prevention. ( Gales, MA; Walker, CK, 2017)
"Recently, two high-quality clinical randomized controlled trials (RCTs) regarding the preventive effect of exogenous melatonin on delirium drew inconsistent conclusions."8.93Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials. ( Chen, S; Desislava, D; Liang, F; Shi, L; Wu, Q; Xu, L; Zhang, J, 2016)
"The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs)."8.91Melatonin and melatonin agonist for delirium in the elderly patients. ( Chakraborti, D; Tampi, DJ; Tampi, RR, 2015)
" All papers on melatonin treatment in dementia were retrieved."8.86Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Consecutive patients admitted to the Tübingen University Stroke Unit, Tübingen, Germany, with acute ischemic stroke (AIS), who underwent standard care between August 2017 and December 2017, and patients who additionally received prophylactic melatonin (2 mg per day at night) within 24 h of symptom onset between August 2018 and December 2018 were included."8.02Delirium REduction after administration of melatonin in acute ischemic stroke (DREAMS): A propensity score-matched analysis. ( Boßelmann, C; Brendel, B; Fleischmann, R; Meisel, A; Mengel, A; Poli, S; Sartor-Pfeiffer, J; Stadler, V; Stefanou, MI; Ziemann, U; Zurloh, J, 2021)
"To compare the effect of prophylactic administration of melatonin, ramelteon, or no melatonin receptor agonist on the development of delirium in the intensive care unit (ICU)."8.02Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon. ( DeGrado, JR; Dube, KM; Lupi, KE; Romero, N, 2021)
"The development of ICU delirium was significantly lower in the melatonin group compared with that in the control group."7.91Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. ( Barnett, M; Baumgartner, L; Gross, K; Lai, J; Lam, K; Morris, A; Thompson, A, 2019)
"To assess if high morning plasma melatonin concentrations were associated with delirium."7.85Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017)
"Abnormalities in melatonin levels have been linked to delirium."7.85Role of Ramelteon in Reduction of As-Needed Antipsychotics in Elderly Patients with Delirium in a General Hospital Setting. ( Fazzari, M; James, SA; Lam, S; Pinkhasov, A; Singh, D, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."7.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"To dynamic monitor and analyze the characteristic of polysomnography (PSG) and melatonin levels of delirium patients in intensive care unit (ICU)."7.80[Research of 24-hour dynamic sleep monitoring and melatonin changes in patients with delirium in intensive care unit]. ( Han, F; Liu, J; Sun, T; Sun, Y; Wang, X; Yang, J, 2014)
"We conducted a prospective observational study to assess the association of perioperative alteration of plasma melatonin concentration with delirium in 40 postoperative patients who required intensive care for more than 48 hours."7.79Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium. ( Egi, M; Kanazawa, T; Morimatsu, H; Morita, K; Toda, Y; Yoshitaka, S, 2013)
"All patients without delirium showed nearly identical preoperative and postoperative melatonin secretion for 24 hours, although peak values were significantly lower in patients more than 80 years old (7."7.71Postoperative delirium and melatonin levels in elderly patients. ( Ikeda, K; Kageyama, M; Machida, N; Menjo, M; Miura, M; Nimura, Y; Shigeta, H; Yasui, A, 2001)
"Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes."6.84Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study. ( Azad, A; Bernard, F; Burry, L; Detsky, M; Fan, E; Foster, J; Guenette, M; Mehta, S; Rose, L; Scales, D; Williamson, D, 2017)
"Melatonin is a naturally occurring, safe and cheap hormone that can be administered to improve sleep."6.84Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial. ( Anstey, M; Choo, L; Ford, A; Hardie, M; Hensley, M; Hillman, D; Kelty, E; Martinez, FE; Murray, K; Palmer, R; Roberts, B; Singh, B; Wibrow, B, 2017)
"Delirium is a frequent, costly and morbid problem."6.82Moderate dose melatonin for the abatement and treatment of delirium in elderly general medical inpatients: study protocol of a placebo controlled, randomised, double blind trial. ( Clayton-Chubb, DI; Lange, PW, 2016)
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."6.76The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011)
"Melatonin levels have been shown to decline with aging."6.53Melatonin based therapies for delirium and dementia. ( Alagiakrishnan, K, 2016)
"Melatonin has a major role in control of circadian rhythm and sleep regulation and other effects on the immune system, neuroprotection, and oxidant/anti-oxidant activity."6.48Potential use of melatonin in sleep and delirium in the critically ill. ( Bellapart, J; Boots, R, 2012)
"Melatonin has been suggested as a low-risk pharmacological intervention to help prevent POD."5.72Melatonin for the prevention of postoperative delirium in older adults: a protocol for a systematic review and meta-analysis. ( Armstrong, RA; Barnes, J; Gibbison, B; Hinchliffe, R; Mouton, R; Pufulete, M; Sewart, E, 2022)
"Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are the most common central nervous system dysfunctions during the perioperative period."5.62Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction. ( Mu, S; Wu, A; Wu, Y, 2021)
" There was no significant difference in the average proportion of delirium-free assessments per patient between the melatonin and placebo groups (79."5.51Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial. ( Anstey, M; Chapman, A; Ford, A; Hawkins, D; Ho, KM; Kelty, E; Litton, E; Martinez, FE; McCaffrey, J; Murray, K; Myers, E; Rashid, A; Regli, A; van Haren, FMP; Wibrow, B; Wyer, S, 2022)
"The current study (clinical trial registered number: CHWX-904-201511) suggests that acute melatonin treatment can reduce the incidence of delirium for elderly acute heart failure."5.51Effects of Melatonin for Delirium in Elderly Acute Heart Failure Patients: A Randomized, Single-Center, Double-Blind, and Placebo-Controlled Trial. ( Gu, L; Liu, X; Wan, R; Ye, T; Yin, B; Zong, G, 2022)
"Both insomnia and its treatment can lead to the development of delirium in older adults."5.48Delirium associated with only one dose of zopiclone in an older adult. ( Isik, AT; Kalan, U; Soysal, P, 2018)
"Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal."5.43Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol. ( Burry, LD; Cheung, A; Chimunda, T; Choong, K; Duffett, M; Foster, J; Guenette, M; Menon, K; Rose, L; Thabane, L, 2016)
"Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality."5.42The diurnal profile of melatonin during delirium in elderly patients--preliminary results. ( Grodzicki, T; Klich-Rączka, A; Pac, A; Piotrowicz, K; Zdzienicka, A, 2015)
"Experimental evidence has indicated the benefits of melatonin (Mel) for the treatment of delirium."5.41Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial. ( Shi, Y, 2021)
"Although ramelteon has been examined as a relatively new therapeutic option for delirium prevention, current evidence to evaluate its efficacy is limited."5.41Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials. ( Carvalho, AF; Chang, CH; Hsu, CW; Hsu, TW; Liang, CS; Thompson, T; Tsai, TC; Tseng, PT; Tu, YK; Yang, FC; Yang, SN; Yu, CL, 2023)
"To assess the efficacy of melatonin and melatonergic agonist for the treatment of delirium in hospitalized patients."5.41Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis. ( Beaucage-Charron, J; Coveney, R; Rinfret, J; Williamson, D, 2023)
"To determine the preventive effect of melatonin on delirium in the intensive care units."5.41Melatonin intervention to prevent delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Bao, Q; Duan, Y; Shao, J; Wan, L; Wan, X; Wang, G; Yang, Y; Yue, J; Zhu, W, 2023)
"To determine the feasibility of a trial of oral melatonin 5 mg nightly for five nights for the treatment of delirium in older medical inpatients, and determine the participants required to demonstrate a clinically and statistically significant decrease in severity of delirium in older medical inpatients treated with melatonin."5.41Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients. ( Clayton-Chubb, DI; Lange, PW; Maier, AB; Watson, R, 2021)
"The 'Prophylactic Melatonin for Delirium in Intensive Care' study is a multi-centre, randomised, double-blinded, placebo-controlled trial."5.41Statistical analysis plan for the Prophylactic Melatonin for Delirium in Intensive Care (ProMEDIC): a randomised controlled trial. ( Anstey, M; Ford, A; Ho, KM; Kelty, E; Litton, E; Martinez, FE; Murray, K; Myers, E; Wibrow, B, 2021)
"Melatonin may be effective in reducing the severity of delirium after cardiac surgery."5.41Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. ( Janatmakan, F; Javaherforoosh Zadeh, F; Jorairahmadi, S; Shafaeebejestan, E, 2021)
"Melatonin has a key role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."5.38[Delirium, insomnia in hospitalization and ramelteon]. ( Ito, T, 2012)
"Delirium is a common and serious acute neuropsychiatric syndrome characterized by inattention and global cognitive dysfunction."5.38Marked improvement in delirium with ramelteon: five case reports. ( Furuya, M; Horiguchi, J; Miyaoka, T; Otsuka, S; Tanaka, I; Wake, R; Yamashita, S; Yasuda, H, 2012)
" Forty-two participants developed delirium, but it was evenly distributed between the groups (melatonin 21/98, 21."5.34The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Kelly, R; Passage, J; Patel, H; Wibrow, B, 2020)
"The Basel BOMP-AID study is an investigator-initiated, single-centre, randomised controlled clinical trial for the treatment of hypoactive delirium with the once daily oral administration of melatonin 4 mg versus placebo in 190 critically ill patients."5.34Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID s ( Abdelhamid, S; Cajochen, C; Gebhard, CE; Hollinger, A; Huber, J; Reinhold, S; Siegemund, M; Steiner, LA; Sutter, R; Todorov, A; Tran, F; von Felten, S, 2020)
" The respective melatonin (n = 30) vs placebo (n = 30) outcomes were: incident delirium in 11/30 (36."5.34Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial. ( Agar, M; Bush, SH; Currow, DC; Dasgupta, M; Lacaze-Masmonteil, N; Lawlor, PG; MacDonald, AR; McNamara-Kilian, MT; Momoli, F; Pereira, JL; Tierney, S, 2020)
"Postoperative delirium is a common problem associated with increased morbidity and mortality, prolonged hospital stay, additional tests and consultations and therefore, increased cost (1,2)."5.31Melatonin for treatment and prevention of postoperative delirium. ( Hanania, M; Kitain, E, 2002)
"In this randomized control trial, a total of 59 AOPP patients with subsequent delirium were randomly divided into two groups, the melatonin group (n=29) and the placebo-controlled group (n=30)."5.27Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients. ( Du, GH; Li, ZF; Pan, YY; Zhang, Y; Zhao, LB; Zhen, GD; Zhou, SZ, 2018)
"Studies suggest that melatonin may prevent delirium, a condition of acute brain dysfunction occurring in 20%-30% of hospitalized older adults that is associated with increased morbidity and mortality."5.27Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial. ( Garcia, S; Jaiswal, SJ; Kang, DY; Loeks, M; Lu, CY; McCarthy, TJ; Owens, RL; Song, J; van Niekerk, CJ; Wineinger, NE, 2018)
"Although a previous review illustrated the efficacy of melatonin receptor agonists (MRAs) in preventing delirium, some recent randomized controlled trials (RCTs) did not confirm these effects."5.22Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Kawilapat, S; Kongsaengdao, S; Likhitsathian, S; Maneeton, B; Maneeton, N; Srisurapanont, M; Woottiluk, P, 2022)
"Studies on melatonin and melatonergic agents (MMA) for the prevention of postoperative delirium (POD) have produced inconsistent findings."5.22Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials. ( Wang, CM; Zhou, LY, 2022)
"The Healthy Heart-Mind trial is a randomized, double-blind, placebo-controlled clinical trial of 3 mg melatonin or matching placebo administered on seven consecutive days for the prevention of delirium following cardiac surgery."5.22The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Passage, J; Wibrow, B, 2016)
"Patients enrolled in a randomized controlled clinical trial of melatonin versus placebo on occurrence of delirium in hip-fracture patients."5.20In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration. ( Blom, MT; de Boer, A; de Jonghe, A; de Rooij, SE; Jansen, S; Tan, HL; van der Velde, N; van Munster, BC, 2015)
" Patients with or without delirium (as assessed using the Confusion Assessment Method for the ICU) were compared in terms of baseline characteristics and outcomes and the circadian rhythm of melatonin excretion using the 24-h excretion of its urinary metabolite 6-sulfatoxymelatonin (aMT6s)."5.20Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial. ( Brochard, L; Brun-Buisson, C; Charles-Nelson, A; Dessap, AM; Katsahian, S; Launay, JM; Roche-Campo, F, 2015)
"To determine whether the postoperative administration of tryptophan would be beneficial for elderly adults undergoing surgery who are at risk of developing postoperative delirium."5.19Tryptophan supplementation and postoperative delirium--a randomized controlled trial. ( Adams, JC; Dunn, CL; Hawkins, CL; Moss, M; Raeburn, CD; Robinson, TN; Tran, ZV, 2014)
"In this older population with hip fracture, treatment with melatonin did not reduce the incidence of delirium."5.19Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. ( de Haan, RJ; de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Levi, M; van Munster, BC; van Rees, C; van Velde, R; Wolvius, R, 2014)
", melatonin) may have a role in the pathogenesis of delirium."5.15Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. ( Al-Aama, T; Brymer, C; Dasgupta, M; Esbaugh, J; Gutmanis, I; Woolmore-Goodwin, SM, 2011)
" In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium."5.12Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021)
"Melatonin, a pineal gland hormone is reported to have a protective effect against delirium."5.12Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis. ( Khaing, K; Nair, BR, 2021)
" We reviewed the literature on the role of melatonin and ramelteon in the prevention of sleep disturbances and delirium in intensive care units and analysed the methods of melatonin therapy in an ICU setting."5.05The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review. ( Cubała, WJ; Lewandowska, K; Małkiewicz, MA; Mędrzycka-Dąbrowska, WA; Siemiński, M; Winklewski, PJ, 2020)
" Incidence of delirium was not significantly lower in patients who received melatonin, with an odd ratio, OR (95%Cl) of 0."5.05The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. ( Khor, AJ; Ng, KT; Teoh, WY, 2020)
" Studies reporting outcomes for melatonin or ramelteon use to prevent delirium in postoperative hospitalized patients (mean age ≥ 50 years) were eligible for inclusion."5.01Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis. ( Axon, DR; Campbell, AM; Lee, JK; Martin, JR; Mollon, L; Slack, MK, 2019)
"To investigate the efficacy of exogenous administration of melatonin and melatonin receptor agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in the intensive care unit (ICU)."5.01Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Gao, F; Li, Z; Sun, W; Zhang, Q; Zhang, S, 2019)
"To review the prospective controlled trials available for the use of melatonin receptor agonists for delirium prevention."4.95Melatonin Receptor Agonists for Delirium Prevention. ( Gales, MA; Walker, CK, 2017)
"Recently, two high-quality clinical randomized controlled trials (RCTs) regarding the preventive effect of exogenous melatonin on delirium drew inconsistent conclusions."4.93Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials. ( Chen, S; Desislava, D; Liang, F; Shi, L; Wu, Q; Xu, L; Zhang, J, 2016)
"The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs)."4.91Melatonin and melatonin agonist for delirium in the elderly patients. ( Chakraborti, D; Tampi, DJ; Tampi, RR, 2015)
", risperidone or olanzapine), and melatonin may be effective in reducing the incidence of postoperative delirium, but the data are not robust."4.90Pharmacologic prevention of postoperative delirium. ( Gosch, M; Nicholas, JA, 2014)
" All papers on melatonin treatment in dementia were retrieved."4.86Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Melatonin has been trialed with reported increasing use for sleep dysregulation and prevention of ICU delirium in critically ill adults; however, reports of use in hospitalized pediatric patients are limited."4.02Melatonin Administration Patterns for Pediatric Inpatients in a Tertiary Children's Hospital. ( Kudchadkar, SR; Procaccini, DE, 2021)
"Consecutive patients admitted to the Tübingen University Stroke Unit, Tübingen, Germany, with acute ischemic stroke (AIS), who underwent standard care between August 2017 and December 2017, and patients who additionally received prophylactic melatonin (2 mg per day at night) within 24 h of symptom onset between August 2018 and December 2018 were included."4.02Delirium REduction after administration of melatonin in acute ischemic stroke (DREAMS): A propensity score-matched analysis. ( Boßelmann, C; Brendel, B; Fleischmann, R; Meisel, A; Mengel, A; Poli, S; Sartor-Pfeiffer, J; Stadler, V; Stefanou, MI; Ziemann, U; Zurloh, J, 2021)
"To compare the effect of prophylactic administration of melatonin, ramelteon, or no melatonin receptor agonist on the development of delirium in the intensive care unit (ICU)."4.02Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon. ( DeGrado, JR; Dube, KM; Lupi, KE; Romero, N, 2021)
"The development of ICU delirium was significantly lower in the melatonin group compared with that in the control group."3.91Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. ( Barnett, M; Baumgartner, L; Gross, K; Lai, J; Lam, K; Morris, A; Thompson, A, 2019)
" Exposure to melatonin or antipsychotic agents did not reduce the duration of ICU delirium, ICU/hospital length of stay, or 28-day mortality."3.88Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality. ( Daniels, LM; Frank, RD; Nelson, SB; Park, JG, 2018)
"To assess if high morning plasma melatonin concentrations were associated with delirium."3.85Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017)
"Abnormalities in melatonin levels have been linked to delirium."3.85Role of Ramelteon in Reduction of As-Needed Antipsychotics in Elderly Patients with Delirium in a General Hospital Setting. ( Fazzari, M; James, SA; Lam, S; Pinkhasov, A; Singh, D, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."3.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"To dynamic monitor and analyze the characteristic of polysomnography (PSG) and melatonin levels of delirium patients in intensive care unit (ICU)."3.80[Research of 24-hour dynamic sleep monitoring and melatonin changes in patients with delirium in intensive care unit]. ( Han, F; Liu, J; Sun, T; Sun, Y; Wang, X; Yang, J, 2014)
"We conducted a prospective observational study to assess the association of perioperative alteration of plasma melatonin concentration with delirium in 40 postoperative patients who required intensive care for more than 48 hours."3.79Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium. ( Egi, M; Kanazawa, T; Morimatsu, H; Morita, K; Toda, Y; Yoshitaka, S, 2013)
"All patients without delirium showed nearly identical preoperative and postoperative melatonin secretion for 24 hours, although peak values were significantly lower in patients more than 80 years old (7."3.71Postoperative delirium and melatonin levels in elderly patients. ( Ikeda, K; Kageyama, M; Machida, N; Menjo, M; Miura, M; Nimura, Y; Shigeta, H; Yasui, A, 2001)
"Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes."2.84Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study. ( Azad, A; Bernard, F; Burry, L; Detsky, M; Fan, E; Foster, J; Guenette, M; Mehta, S; Rose, L; Scales, D; Williamson, D, 2017)
"Melatonin is a naturally occurring, safe and cheap hormone that can be administered to improve sleep."2.84Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial. ( Anstey, M; Choo, L; Ford, A; Hardie, M; Hensley, M; Hillman, D; Kelty, E; Martinez, FE; Murray, K; Palmer, R; Roberts, B; Singh, B; Wibrow, B, 2017)
"Delirium is a common neuropsychiatric syndrome with considerable heterogeneity in clinical profile."2.82Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium. ( Adamis, D; de Jonghe, A; de Rooij, SE; Meagher, DJ; Scholtens, RM; van Munster, BC, 2016)
"Delirium is a frequent, costly and morbid problem."2.82Moderate dose melatonin for the abatement and treatment of delirium in elderly general medical inpatients: study protocol of a placebo controlled, randomised, double blind trial. ( Clayton-Chubb, DI; Lange, PW, 2016)
"Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."2.76The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. ( de Jonghe, A; de Rooij, SE; Goslings, JC; Kloen, P; Korevaar, JC; Levi, MM; van Munster, BC; van Oosten, HE; van Rees, C; van Velde, R; Wolvius, R, 2011)
"Delirium is a very common but annoying clinical state that interferes with the treatment of background disease and delays recovery."2.72Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium. ( Enomoto, R; Lee-Hiraiwa, E, 2021)
"Postoperative delirium is a common sequela in older adults in the peri-operative period leading to poor outcomes with a complex pathophysiology which has led to a variety of different pharmacologic agents employed in attempts to prevent and treat this syndrome."2.66The pharmacotherapeutic management of postoperative delirium: an expert update. ( Scicutella, A, 2020)
"Delirium is a common mental disorder, which is distressing and has serious adverse outcomes in hospitalised patients."2.53Interventions for preventing delirium in hospitalised non-ICU patients. ( Clegg, A; Harrison, JK; Siddiqi, N; Simpkins, SA; Taylor, J; Teale, EA; Young, J, 2016)
"Melatonin levels have been shown to decline with aging."2.53Melatonin based therapies for delirium and dementia. ( Alagiakrishnan, K, 2016)
"Delirium is a common occurrence in older hospitalised patients, particularly in the setting of surgical intervention and acute illness."2.52Pharmacological interventions for preventing delirium in the elderly. ( Almeida, OP; Ford, AH, 2015)
"Delirium is a complex neurobehavioral syndrome caused by dysregulation of brain activity, characterized by an alteration in the level of attention and awareness, which develops over a short period of time and is seen as a change from the patient's baseline."2.50Delirium and its prevention with melatonergic drugs. ( Howland, RH, 2014)
"Delirium is a serious and common problem in severely medically ill patients of all ages."2.50The pharmacologic management of delirium in children and adolescents. ( Hanft, A; Turkel, SB, 2014)
"Delirium is a serious neuropsychiatric syndrome of acute onset that occurs in approximately one in five general hospital patients and is associated with serious adverse outcomes that include loss of adaptive function, persistent cognitive problems and increased mortality."2.49Delirium: a disturbance of circadian integrity? ( Adamis, D; Dunne, C; Fitzgerald, JM; Meagher, DJ; O'Regan, N; Timmons, S; Trzepacz, PT, 2013)
"Melatonin has a major role in control of circadian rhythm and sleep regulation and other effects on the immune system, neuroprotection, and oxidant/anti-oxidant activity."2.48Potential use of melatonin in sleep and delirium in the critically ill. ( Bellapart, J; Boots, R, 2012)
"Melatonin has been suggested as a low-risk pharmacological intervention to help prevent POD."1.72Melatonin for the prevention of postoperative delirium in older adults: a protocol for a systematic review and meta-analysis. ( Armstrong, RA; Barnes, J; Gibbison, B; Hinchliffe, R; Mouton, R; Pufulete, M; Sewart, E, 2022)
"Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are the most common central nervous system dysfunctions during the perioperative period."1.62Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction. ( Mu, S; Wu, A; Wu, Y, 2021)
"Pediatric COVID-19 delirium is a new manifestation of the COVID-19 disease."1.62Pediatric COVID-19 Delirium: Case Report of 2 Adolescents. ( Bauer, SC; Logan, A; Manak, C; Mitchell, M; Moral, F; Preloger, E; Roman, M; Sandage, SJ; Spindler, A, 2021)
"Melatonin is an endogenous hormone exerting multiple biological effects, mainly in regulating diurnal rhythms, also in inflammatory process and immune response."1.56Assessment of melatonergics in prevention of delirium in critically ill patients: A protocol for systematic review and meta-analysis. ( Du, B; Huang, H; Jiang, Z; Li, W; Ren, C; Wang, Y; Xi, X; Yao, Y; Zhang, L; Zhu, Y, 2020)
"Both insomnia and its treatment can lead to the development of delirium in older adults."1.48Delirium associated with only one dose of zopiclone in an older adult. ( Isik, AT; Kalan, U; Soysal, P, 2018)
"Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal."1.43Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol. ( Burry, LD; Cheung, A; Chimunda, T; Choong, K; Duffett, M; Foster, J; Guenette, M; Menon, K; Rose, L; Thabane, L, 2016)
"Delirium has been associated with morbidity and mortality including more ventilator days, longer ICU stay, increased long-term mortality and cognitive impairment."1.43Pharmacological interventions for delirium in intensive care patients: a protocol for an overview of reviews. ( Barbateskovic, M; Jakobsen, JC; Larsen, LK; Oxenbøll-Collet, M; Perner, A; Wetterslev, J, 2016)
"Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality."1.42The diurnal profile of melatonin during delirium in elderly patients--preliminary results. ( Grodzicki, T; Klich-Rączka, A; Pac, A; Piotrowicz, K; Zdzienicka, A, 2015)
"Melatonin has a key role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium."1.38[Delirium, insomnia in hospitalization and ramelteon]. ( Ito, T, 2012)
"Delirium is a common and serious acute neuropsychiatric syndrome characterized by inattention and global cognitive dysfunction."1.38Marked improvement in delirium with ramelteon: five case reports. ( Furuya, M; Horiguchi, J; Miyaoka, T; Otsuka, S; Tanaka, I; Wake, R; Yamashita, S; Yasuda, H, 2012)
"Delirium is a common syndrome among hospitalized elderly patients."1.32The relation between the clinical subtypes of delirium and the urinary level of 6-SMT. ( Balan, S; Blagman, B; Chana, W; Habot, B; Leibovitz, A; Neumann, E; Rahel, B; Richard, G; Ruth, M; Yassica, B; Zila, SO, 2003)
"Postoperative delirium is a common problem associated with increased morbidity and mortality, prolonged hospital stay, additional tests and consultations and therefore, increased cost (1,2)."1.31Melatonin for treatment and prevention of postoperative delirium. ( Hanania, M; Kitain, E, 2002)

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.03)18.2507
2000's9 (9.28)29.6817
2010's50 (51.55)24.3611
2020's37 (38.14)2.80

Authors

AuthorsStudies
Mu, S1
Wu, Y1
Wu, A1
Procaccini, DE1
Kudchadkar, SR1
Shi, Y1
Kanova, M1
Kohout, P1
Sigaut, S1
Couffignal, C1
Esposito-Farèse, M1
Degos, V1
Molliex, S1
Boddaert, J1
Raynaud-Simon, A1
Durand-Zaleski, I1
Marcault, E1
Jacota, M1
Dahmani, S1
Paugam-Burtz, C1
Weiss, E1
Wibrow, B5
Martinez, FE3
Myers, E2
Chapman, A1
Litton, E2
Ho, KM2
Regli, A1
Hawkins, D1
Ford, A3
van Haren, FMP1
Wyer, S1
McCaffrey, J1
Rashid, A1
Kelty, E3
Murray, K3
Anstey, M5
Yin, B1
Ye, T1
Liu, X1
Wan, R1
Gu, L1
Zong, G1
Burry, L2
Sonneville, R1
Ely, EW1
Maneeton, B1
Kongsaengdao, S1
Maneeton, N1
Likhitsathian, S1
Woottiluk, P1
Kawilapat, S1
Srisurapanont, M1
Lee, EY1
Wilcox, ME1
Sewart, E1
Barnes, J1
Armstrong, RA1
Pufulete, M1
Hinchliffe, R1
Gibbison, B1
Mouton, R1
Yu, CL1
Carvalho, AF1
Thompson, T1
Tsai, TC1
Tseng, PT2
Tu, YK1
Yang, SN1
Yang, FC1
Chang, CH1
Hsu, CW1
Hsu, TW1
Liang, CS1
Beaucage-Charron, J1
Rinfret, J1
Coveney, R1
Williamson, D2
Duan, Y1
Yang, Y1
Zhu, W1
Wan, L1
Wang, G2
Yue, J1
Bao, Q1
Shao, J1
Wan, X1
Moeri, L1
Mini, P1
Gironi, C1
Eshmawey, M1
Ford, AH3
Flicker, L2
Kelly, R1
Patel, H1
Passage, J2
Edwards, M2
Almeida, OP3
Campbell, AM1
Axon, DR1
Martin, JR1
Slack, MK1
Mollon, L1
Lee, JK1
Yang, CP1
Pei-Chen Chang, J1
Su, H1
Satyanarayanan, SK1
Su, KP1
Zhu, Y1
Jiang, Z1
Huang, H1
Wang, Y1
Zhang, L1
Ren, C1
Yao, Y1
Li, W1
Du, B1
Xi, X1
Lange, PW2
Clayton-Chubb, DI2
Watson, R1
Maier, AB1
Lewandowska, K1
Małkiewicz, MA1
Siemiński, M1
Cubała, WJ1
Winklewski, PJ1
Mędrzycka-Dąbrowska, WA1
Scicutella, A1
Shen, QH1
Li, HF1
Zhou, XY1
Lu, YP1
Yuan, XZ1
Enomoto, R1
Lee-Hiraiwa, E1
Hollinger, A1
von Felten, S1
Sutter, R1
Huber, J1
Tran, F1
Reinhold, S1
Abdelhamid, S1
Todorov, A1
Gebhard, CE1
Cajochen, C1
Steiner, LA1
Siegemund, M1
Zambrelli, E2
Canevini, M1
Gambini, O1
D'Agostino, A2
Wiwanitkit, V1
Lawlor, PG1
McNamara-Kilian, MT1
MacDonald, AR1
Momoli, F1
Tierney, S1
Lacaze-Masmonteil, N1
Dasgupta, M2
Agar, M1
Pereira, JL1
Currow, DC1
Bush, SH1
Khaing, K1
Nair, BR1
Yuan, Y1
Song, Y1
Jia, Y1
Zhou, Y1
Mi, X1
Jia, X1
Wang, X2
Liu, C1
Li, Y1
Shi, C1
Han, Y1
Guo, X1
Zhang, W1
Li, Z2
Mengel, A1
Zurloh, J1
Boßelmann, C1
Brendel, B1
Stadler, V1
Sartor-Pfeiffer, J1
Meisel, A1
Fleischmann, R1
Ziemann, U1
Poli, S1
Stefanou, MI1
Romero, N1
Dube, KM1
Lupi, KE1
DeGrado, JR1
Javaherforoosh Zadeh, F1
Janatmakan, F1
Shafaeebejestan, E1
Jorairahmadi, S1
Wang, CM1
Zhou, LY1
Bauer, SC1
Moral, F1
Preloger, E1
Spindler, A1
Roman, M1
Logan, A1
Sandage, SJ1
Manak, C1
Mitchell, M1
Scales, D1
Foster, J2
Mehta, S1
Guenette, M2
Fan, E1
Detsky, M1
Azad, A1
Bernard, F1
Rose, L2
Scholtens, RM3
van Munster, BC10
van Faassen, M1
van Kempen, MF1
Kema, IP1
de Rooij, SE10
Pinkhasov, A1
James, SA1
Fazzari, M1
Singh, D1
Lam, S1
Zhao, LB1
Zhen, GD1
Zhang, Y1
Pan, YY1
Du, GH1
Zhou, SZ1
Li, ZF1
Jaiswal, SJ1
McCarthy, TJ1
Wineinger, NE1
Kang, DY1
Song, J1
Garcia, S1
van Niekerk, CJ1
Lu, CY1
Loeks, M1
Owens, RL1
Kalan, U1
Soysal, P1
Isik, AT1
Daniels, LM1
Nelson, SB1
Frank, RD1
Park, JG1
Baumgartner, L1
Lam, K1
Lai, J1
Barnett, M1
Thompson, A1
Gross, K1
Morris, A1
Marra, A1
McGrane, TJ1
Henson, CP1
Pandharipande, PP1
Zhang, Q1
Gao, F1
Zhang, S1
Sun, W1
Ng, KT1
Teoh, WY1
Khor, AJ1
Liu, D1
An, YZ1
Lammers, M1
Ahmed, AIA1
Fitzgerald, JM1
Adamis, D2
Trzepacz, PT1
O'Regan, N1
Timmons, S1
Dunne, C1
Meagher, DJ2
van de Glind, EM1
Vural, EM1
Scholten, E1
Hooft, L1
Portegijs, E1
de Jonghe, A6
Gosch, M1
Nicholas, JA1
Howland, RH1
Turkel, SB1
Hanft, A1
Chakraborti, D1
Tampi, DJ1
Tampi, RR1
Robinson, TN1
Dunn, CL1
Adams, JC1
Hawkins, CL1
Tran, ZV1
Raeburn, CD1
Moss, M1
Goslings, JC2
Kloen, P2
van Rees, C2
Wolvius, R2
van Velde, R2
Levi, M1
de Haan, RJ1
Sun, T1
Han, F1
Sun, Y1
Liu, J1
Yang, J1
Blom, MT1
Jansen, S1
de Boer, A1
Tan, HL1
van der Velde, N1
Mo, Y1
Scheer, CE1
Abdallah, GT1
Madrid-Navarro, CJ1
Sanchez-Galvez, R1
Martinez-Nicolas, A1
Marina, R1
Garcia, JA1
Madrid, JA1
Rol, MA1
Dessap, AM1
Roche-Campo, F1
Launay, JM1
Charles-Nelson, A1
Katsahian, S1
Brun-Buisson, C1
Brochard, L2
Chen, S1
Shi, L1
Liang, F1
Xu, L1
Desislava, D1
Wu, Q1
Zhang, J1
Piotrowicz, K1
Klich-Rączka, A1
Pac, A1
Zdzienicka, A1
Grodzicki, T1
Siddiqi, N1
Harrison, JK1
Clegg, A1
Teale, EA1
Young, J1
Taylor, J1
Simpkins, SA1
Alagiakrishnan, K1
Messerschmidt, K1
Walker, CK1
Gales, MA1
Burry, LD1
Thabane, L1
Choong, K1
Menon, K1
Duffett, M1
Cheung, A1
Chimunda, T1
Barbateskovic, M1
Larsen, LK1
Oxenbøll-Collet, M1
Jakobsen, JC1
Perner, A1
Wetterslev, J1
Vellekoop, AE1
Vrouenraets, BC1
Roberts, B1
Hardie, M1
Palmer, R1
Choo, L1
Hillman, D1
Hensley, M1
Singh, B1
Yousaf, F1
Seet, E1
Venkatraghavan, L1
Katznelson, R1
Chung, F1
Al-Aama, T1
Brymer, C1
Gutmanis, I1
Woolmore-Goodwin, SM1
Esbaugh, J1
Korevaar, JC2
van Oosten, HE1
Levi, MM1
Bellapart, J1
Boots, R1
Ito, T1
Furuya, M1
Miyaoka, T1
Yasuda, H1
Yamashita, S1
Tanaka, I1
Otsuka, S1
Wake, R1
Horiguchi, J1
Yoshitaka, S1
Egi, M1
Morimatsu, H1
Kanazawa, T1
Toda, Y1
Morita, K1
Balan, S1
Leibovitz, A1
Zila, SO1
Ruth, M1
Chana, W1
Yassica, B1
Rahel, B1
Richard, G1
Neumann, E1
Blagman, B1
Habot, B1
Lewis, MC1
Barnett, SR1
Marcantonio, ER1
Rudolph, JL1
Culley, D1
Crosby, G1
Alsop, D1
Inouye, SK1
Short, MR1
Winstead, PS1
Sharer, J1
Drouot, X1
Cabello, B1
d'Ortho, MP1
Uchida, K1
Aoki, T1
Ishizuka, B1
Sher, L1
Shigeta, H1
Yasui, A1
Nimura, Y1
Machida, N1
Kageyama, M1
Miura, M1
Menjo, M1
Ikeda, K1
Hanania, M1
Kitain, E1

Clinical Trials (28)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients: a Randomized Controlled Trial[NCT04335968]Phase 3790 participants (Anticipated)Interventional2021-01-23Recruiting
Better Outcome With Melatonin Compared to Placebo Administered to Normalize Sleep-wake Cycle and Treat Hypoactive ICU Delirium The Basel BOMP-AID Randomized Trial[NCT03438526]Phase 4190 participants (Anticipated)Interventional2022-01-03Recruiting
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]Phase 260 participants (Actual)Interventional2014-12-31Completed
DELIRE-ICU: A Randomised Controlled Feasibility Trial of Melatonin vs Placebo in the Treatment of Delirium in the Intensive Care Unit[NCT05713877]Phase 230 participants (Anticipated)Interventional2023-02-01Recruiting
Feasibility of Melatonin for Prevention of Delirium in Critically Ill Patients: a Multi-centre, Randomized, Placebo-controlled Study.[NCT02615340]Phase 269 participants (Anticipated)Interventional2017-10-12Recruiting
Melatonin and Sleep in Preventing Delirium in the Hospital: A Randomized Placebo-controlled Trial[NCT02597231]Phase 1/Phase 294 participants (Actual)Interventional2015-11-30Completed
Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950]104 participants (Anticipated)Interventional2017-06-26Recruiting
Melatonin Use in the Intensive Care Elderly Population[NCT03013790]Phase 4600 participants (Anticipated)Interventional2016-12-31Recruiting
Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314]Phase 3277 participants (Actual)Interventional2016-07-31Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.)
Impact of Low-dose Dexmedetomidine on Outcomes of Elderly Admitted to ICU After Noncardiac Surgery: a Randomized Controlled Trial[NCT04204798]1,410 participants (Anticipated)Interventional2020-08-28Recruiting
Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study[NCT05307003]60 participants (Anticipated)Observational2023-04-01Recruiting
Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)[NCT05085808]Phase 430 participants (Anticipated)Interventional2024-03-01Not yet recruiting
Weaning of Mechanical Ventilation Guided by the Natriuretic Peptide of Type B[NCT00473148]Phase 3265 participants (Actual)Interventional2007-06-30Completed
Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012971]1,500 participants (Actual)Interventional2017-01-06Active, not recruiting
Evaluating the Effects of Implementing an Scenario-based Education Initiative and OSCE for Recognition and Management of Delirium in Adult Intensive Care Unit: Randomised Controlled Trial[NCT03642249]72 participants (Actual)Interventional2019-11-05Completed
Impact of Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block on Postoperative Delirium and Long-term Oucomes in Elderly Patients After Single Knee Arthroplasty[NCT03629483]Phase 4736 participants (Anticipated)Interventional2018-12-10Suspended (stopped due to Trial stopped by the sponsor because of no funding.)
Can the Hospital's Architectural Design Affect the Incidence and Treatment of Delirium in Geriatric Patients? A Comparison Between Single-bed and Multibed Rooms[NCT03199768]1,014 participants (Actual)Observational2016-09-15Completed
Predict IQCODE Delirium in Geriatric Patients[NCT03175276]315 participants (Actual)Observational2017-03-20Completed
Impact of Dexmedetomidine Supplemented Intravenous Analgesia on Postoperative Delirium and Long-term Outcomes in Elderly After Orthopedic Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT03629262]Phase 4712 participants (Actual)Interventional2018-10-28Active, not recruiting
Impact of Dexmedetomidine Supplemented Analgesia on Incidence of Delirium in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012984]1,500 participants (Actual)Interventional2017-01-06Completed
Validation of Cerebral Non-invasive Monitoring and Prediction of Post-operative Delirium and Outcomes: A Prospective Observational Study[NCT04643834]151 participants (Anticipated)Observational2019-11-21Recruiting
Impact of Perioperative Nutritional Intervention on Perioperative Outcomes of Elderly Patients Having Hip Fracture Surgery: A Randomized Control Trial[NCT04451538]970 participants (Anticipated)Interventional2020-12-28Recruiting
The Impact of Ramelteon on Sleep and Delirium in Patients Who Undergo Pulmonary Thromboendarterectomy (PTE) Surgery[NCT02691013]120 participants (Actual)Interventional2016-02-29Active, not recruiting
Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465]50 participants (Actual)Interventional2012-02-29Completed
Association of Plasma Melatonin Levels With Delirium After Sevoflurane Anesthesia[NCT01570881]33 participants (Actual)Observational2010-04-30Completed
Relationship Between Asynchronies and Sleep Disruption in Mechanically Ventilated Patients: a Prospective Cohort Study[NCT05847374]50 participants (Actual)Observational2019-01-01Completed
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation[NCT02464735]44 participants (Actual)Observational2016-01-01Completed
Usefulness of Bright Light Therapy in the Prevention of Delirium in Patients Undergoing Hematopoietic Stem Cell Transplant (HSCT)[NCT01700816]40 participants (Actual)Interventional2012-10-31Terminated (stopped due to Low incidence of delirium.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Days Utilizing Restraints

Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventiondays (Median)
Melatonin0
Cellulose Microcrystylline0

Delirium

Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

InterventionParticipants (Count of Participants)
Melatonin2
Cellulose Microcrystylline8

Length of Hospital Stay

Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days

Interventiondays (Mean)
Melatonin4.58
Cellulose Microcrystylline4.71

Number of Delirium Anti-psychotic Drug Doses Utilized for Delirium During the First 14 Days of Hospitalization.

Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventionnumber of doses per days of hospitalizat (Median)
Melatonin0
Cellulose Microcrystylline0

Duration of Delirium

Measured twice daily during the ICU stay using the Confusions Assessment Method instrument. (NCT02691013)
Timeframe: Twice daily for up to 10 days

Interventionhours (Median)
Placebo16
Ramelteon24

Length of Hospital Stay

(NCT02691013)
Timeframe: Duration of hospital admission

Interventiondays (Median)
Placebo12
Ramelteon12

Length of ICU Stay

(NCT02691013)
Timeframe: Duration of hospital admission

Interventiondays (Median)
Placebo4
Ramelteon4

Number of Participants With Delirium

Measured twice daily over the course of the ICU stay using the Confusion Assessment Method instrument (NCT02691013)
Timeframe: Twice daily for up to 10 days

InterventionParticipants (Count of Participants)
Placebo22
Ramelteon19

Perioperative Sleep Efficiency

Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery

Interventionminutes (Mean)
Study: Melatonin20
Control: Placebo-55

Hematocrit (HCT)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionvolume percentage (vol%) of red blood ce (Median)
Bright Light Therapy28.20
Sham Light26.70

Hemoglobin (HGB)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiong/dl (Median)
Bright Light Therapy9.70
Sham Light9.55

Hospital Length of Stay

(NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiondays (Median)
Bright Light Therapy18
Sham Light18.5

Number of Participants Who Developed Delirium Based on Meeting Criteria on the Delirium Rating Scale and/or Memorial Delirium Assessment Scale

Monday, Wednesday, and Friday assessments will begin after beginning light therapy and include the Delirium Rating Scale-Revised-98 (DRS-98)and Memorial Delirium Assessment Scale (MDAS) (NCT01700816)
Timeframe: From hospital admission until the date of first documented delirium, assessed up to 28 days post-transplant

InterventionParticipants (Count of Participants)
Bright Light Therapy1
Sham Light0

Platelet Count

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionthousand cells/uL (Median)
Bright Light Therapy39
Sham Light33.5

Red Blood Cells (RBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionM/uL (Median)
Bright Light Therapy3.21
Sham Light2.93

Severity of Delirium Episodes: Memorial Delirium Assessment Scale (MDAS)

"Monday, Wednesday, and Friday assessments of the Memorial Delirium Assessment Scale (MDAS); Patients will receive assessments after beginning light therapy until day 28 post-transplant or discharge, whichever comes first.~10 item scale Items are rated on a four-point scale from 0 (none) to 3 (severe) depending on the level of impairment, rendering a maximum possible score of 30.~A score of 13 has been recommended as a cut-off for establishing the diagnosis of delirium" (NCT01700816)
Timeframe: From first documented episode of delirium until discharge from the hospital, assessed up to 28 days post-transplant

Interventionunits on a scale (Number)
Bright Light Therapy18

White Blood Cells (WBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionK/uL (Median)
Bright Light Therapy2.30
Sham Light4.75

Serum Creatinine and Blood Urea Nitrogen (BUN)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmg/dl (Median)
Serum CreatinineBlood Urea Nitrogen (BUN)
Bright Light Therapy0.669
Sham Light0.758.5

Sodium (Na), Potassium (K), Chloride (Cl), and Carbon Dioxide (CO2)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT (Hematopoietic Stem Cell Transplantation). (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmmol/L (Median)
Sodium (Na)Potassium (K)Chloride (Cl)Carbon Dioxide (CO2)
Bright Light Therapy1393.610524.9
Sham Light138.03.80103.025.10

Reviews

37 reviews available for melatonin and Delirium

ArticleYear
Tryptophan: A Unique Role in the Critically Ill.
    International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21

    Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation;

2021
Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Current neuropharmacology, 2022, Volume: 20, Issue:10

    Topics: Aged; Delirium; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Receptors, Melato

2022
Sleep in the intensive care unit.
    Current opinion in pulmonary medicine, 2022, 11-01, Volume: 28, Issue:6

    Topics: Critical Care; Delirium; Dexmedetomidine; Humans; Intensive Care Units; Melatonin; Sleep

2022
Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials.
    Journal of pineal research, 2023, Volume: 74, Issue:3

    Topics: Delirium; Humans; Melatonin; Middle Aged; Randomized Controlled Trials as Topic; Reproducibility of

2023
Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis.
    Journal of psychosomatic research, 2023, Volume: 170

    Topics: Aged; Antipsychotic Agents; Delirium; Humans; Indenes; Melatonin

2023
Melatonin intervention to prevent delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Delirium; Humans; Intensive Care Units; Length of Stay; Melatonin; Randomized Controlled Trials as T

2023
Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis.
    BMC geriatrics, 2019, 10-16, Volume: 19, Issue:1

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Humans; Incidence; Melatonin;

2019
Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials.
    Sleep medicine reviews, 2020, Volume: 50

    Topics: Aged; Delirium; Humans; Indenes; Melatonin; Network Meta-Analysis; Randomized Controlled Trials as T

2020
The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review.
    Sleep medicine, 2020, Volume: 69

    Topics: Chronobiology Disorders; Delirium; Humans; Indenes; Intensive Care Units; Melatonin; Receptors, Mela

2020
The pharmacotherapeutic management of postoperative delirium: an expert update.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:8

    Topics: Aged; Analgesia; Anesthesia; Antipsychotic Agents; Delirium; Dexmedetomidine; Drug Monitoring; Human

2020
Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium.
    Current molecular pharmacology, 2021, Volume: 14, Issue:2

    Topics: Adenosine; Animals; Cholinergic Antagonists; Delirium; Histamine; Humans; Melatonin; Sleep; Sleep Qu

2021
Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis.
    Journal of psychiatric research, 2021, Volume: 133

    Topics: Adult; Delirium; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of Stay; Melatonin

2021
Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials.
    Asian journal of surgery, 2022, Volume: 45, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Delirium; Humans; Incidence; Melatonin; Randomized Controlled Tria

2022
Melatonin in Critical Care.
    Critical care clinics, 2019, Volume: 35, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Critical Care;

2019
Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.
    Sleep & breathing = Schlaf & Atmung, 2019, Volume: 23, Issue:4

    Topics: Adult; Benzofurans; Case-Control Studies; Correlation of Data; Cross-Sectional Studies; Cyclopropane

2019
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.
    Journal of clinical anesthesia, 2020, Volume: 59

    Topics: Delirium; Dizziness; Headache; Hospital Mortality; Humans; Hypnotics and Sedatives; Incidence; Inden

2020
Melatonin deficiency hypothesis in delirium: a synthesis of current evidence.
    Rejuvenation research, 2013, Volume: 16, Issue:4

    Topics: Animals; Circadian Rhythm; Delirium; Humans; Melatonin; Models, Biological; Risk Factors

2013
[Melatonin and delirium].
    Zhonghua wei zhong bing ji jiu yi xue, 2013, Volume: 25, Issue:6

    Topics: Delirium; Humans; Melatonin

2013
Delirium: a disturbance of circadian integrity?
    Medical hypotheses, 2013, Volume: 81, Issue:4

    Topics: Ataxia; Chronobiology Disorders; Cognition Disorders; Delirium; Humans; Melatonin; Models, Biologica

2013
Pharmacologic prevention of postoperative delirium.
    Zeitschrift fur Gerontologie und Geriatrie, 2014, Volume: 47, Issue:2

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Evidence-Based Medicine; Female; Humans; Hy

2014
Delirium and its prevention with melatonergic drugs.
    Journal of psychosocial nursing and mental health services, 2014, Volume: 52, Issue:5

    Topics: Delirium; Humans; Melatonin

2014
The pharmacologic management of delirium in children and adolescents.
    Paediatric drugs, 2014, Volume: 16, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Delirium; Dexmedetomidine; Dibenzothiazepi

2014
Melatonin and melatonin agonist for delirium in the elderly patients.
    American journal of Alzheimer's disease and other dementias, 2015, Volume: 30, Issue:2

    Topics: Aged; Delirium; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic

2015
Pharmacological interventions for preventing delirium in the elderly.
    Maturitas, 2015, Volume: 81, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Antipsychotic Agents; Delirium; Dexmedetomidine; Hospita

2015
Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients.
    Journal of intensive care medicine, 2016, Volume: 31, Issue:7

    Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Indenes; Inte

2016
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
    Current pharmaceutical design, 2015, Volume: 21, Issue:24

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca

2015
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
    Current pharmaceutical design, 2015, Volume: 21, Issue:24

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca

2015
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
    Current pharmaceutical design, 2015, Volume: 21, Issue:24

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca

2015
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
    Current pharmaceutical design, 2015, Volume: 21, Issue:24

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca

2015
Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials.
    Molecular neurobiology, 2016, Volume: 53, Issue:6

    Topics: Aged; Aged, 80 and over; Delirium; Female; Humans; Indenes; Male; Melatonin; Outcome Assessment, Hea

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Interventions for preventing delirium in hospitalised non-ICU patients.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Antipsychotic Agents; Cholinesterase Inhibitors; Cyti

2016
Melatonin based therapies for delirium and dementia.
    Discovery medicine, 2016, Volume: 21, Issue:117

    Topics: Aged; Animals; Antipsychotic Agents; Benzodiazepines; Chronobiology Phenomena; Clinical Trials as To

2016
Melatonin Receptor Agonists for Delirium Prevention.
    The Annals of pharmacotherapy, 2017, Volume: 51, Issue:1

    Topics: Clinical Trials as Topic; Delirium; Female; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Pro

2017
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Potential use of melatonin in sleep and delirium in the critically ill.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car

2012
Potential use of melatonin in sleep and delirium in the critically ill.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car

2012
Potential use of melatonin in sleep and delirium in the critically ill.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car

2012
Potential use of melatonin in sleep and delirium in the critically ill.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car

2012
Serum biomarkers for delirium.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:12

    Topics: Acetylcholine; Amino Acids; Biomarkers; Cholinergic Antagonists; Delirium; Genetic Markers; Humans;

2006
Delirium dilemma.
    Orthopedics, 2007, Volume: 30, Issue:4

    Topics: Antioxidants; Antipsychotic Agents; Benzodiazepines; Delirium; Haloperidol; Hospitalization; Humans;

2007
Tackling sundowning in a patient with Alzheimer's disease.
    Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 2008, Volume: 17, Issue:1

    Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents; Behavior Therapy; Circadian Rhyt

2008
Sleep in the intensive care unit.
    Sleep medicine reviews, 2008, Volume: 12, Issue:5

    Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score

2008
Sleep in the intensive care unit.
    Sleep medicine reviews, 2008, Volume: 12, Issue:5

    Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score

2008
Sleep in the intensive care unit.
    Sleep medicine reviews, 2008, Volume: 12, Issue:5

    Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score

2008
Sleep in the intensive care unit.
    Sleep medicine reviews, 2008, Volume: 12, Issue:5

    Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score

2008
Postoperative delirium and plasma melatonin.
    Medical hypotheses, 1999, Volume: 53, Issue:2

    Topics: Delirium; Humans; Interferons; Melatonin; Models, Biological; Postoperative Complications; Renal Dia

1999

Trials

24 trials available for melatonin and Delirium

ArticleYear
Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial.
    The heart surgery forum, 2021, Oct-21, Volume: 24, Issue:5

    Topics: Aged; Coronary Care Units; Delirium; Double-Blind Method; Female; Humans; Incidence; Intention to Tr

2021
Melatonin for prevention of postoperative delirium after lower limb fracture surgery in elderly patients (DELIRLESS): study protocol for a multicentre randomised controlled trial.
    BMJ open, 2021, 12-24, Volume: 11, Issue:12

    Topics: Aged; Delirium; Double-Blind Method; Hip Fractures; Humans; Lower Extremity; Melatonin; Multicenter

2021
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial.
    Intensive care medicine, 2022, Volume: 48, Issue:4

    Topics: Australia; Critical Care; Critical Illness; Delirium; Double-Blind Method; Humans; Intensive Care Un

2022
Effects of Melatonin for Delirium in Elderly Acute Heart Failure Patients: A Randomized, Single-Center, Double-Blind, and Placebo-Controlled Trial.
    The heart surgery forum, 2022, Jan-17, Volume: 25, Issue:1

    Topics: Aged; Delirium; Double-Blind Method; Heart Failure; Humans; Length of Stay; Melatonin; Treatment Out

2022
The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium.
    Journal of the American Geriatrics Society, 2020, Volume: 68, Issue:1

    Topics: Aged; Cardiac Surgical Procedures; Coronary Artery Bypass; Delirium; Double-Blind Method; Female; Hu

2020
Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients.
    Internal medicine journal, 2021, Volume: 51, Issue:1

    Topics: Aged; Delirium; Double-Blind Method; Feasibility Studies; Humans; Inpatients; Melatonin

2021
Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID s
    BMJ open, 2020, 04-30, Volume: 10, Issue:4

    Topics: Activities of Daily Living; Delirium; Double-Blind Method; Humans; Intensive Care Units; Melatonin;

2020
Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial.
    BMC palliative care, 2020, Oct-21, Volume: 19, Issue:1

    Topics: Aged; Delirium; Double-Blind Method; Feasibility Studies; Female; Humans; Male; Melatonin; Middle Ag

2020
Statistical analysis plan for the Prophylactic Melatonin for Delirium in Intensive Care (ProMEDIC): a randomised controlled trial.
    Trials, 2021, Jan-05, Volume: 22, Issue:1

    Topics: Australia; Critical Care; Delirium; Double-Blind Method; Humans; Intensive Care Units; Melatonin; Tr

2021
Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial.
    Iranian journal of medical sciences, 2021, Volume: 46, Issue:2

    Topics: Aged; Coronary Artery Bypass; Delirium; Double-Blind Method; Female; Humans; Iran; Male; Melatonin;

2021
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
    BMJ open, 2017, 03-30, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum

2017
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
    BMJ open, 2017, 03-30, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum

2017
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
    BMJ open, 2017, 03-30, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum

2017
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
    BMJ open, 2017, 03-30, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum

2017
Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Delirium; Female; Humans; Male; Melatonin; Middle Aged; Orga

2018
Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial.
    The American journal of medicine, 2018, Volume: 131, Issue:9

    Topics: Aged; Aged, 80 and over; Antioxidants; California; Delirium; Double-Blind Method; Female; Hospitaliz

2018
Barriers to and facilitators of participation of older adults in a placebo-controlled randomized clinical trial.
    Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8

    Topics: Aged; Aged, 80 and over; Attitude to Health; Caregivers; Chronobiology Disorders; Comprehension; Del

2013
Tryptophan supplementation and postoperative delirium--a randomized controlled trial.
    Journal of the American Geriatrics Society, 2014, Volume: 62, Issue:9

    Topics: Aged; Antidepressive Agents, Second-Generation; Delirium; Double-Blind Method; Elective Surgical Pro

2014
Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Oct-07, Volume: 186, Issue:14

    Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Delirium; Double-Blind Method; Female; Frac

2014
In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration.
    The journal of nutrition, health & aging, 2015, Volume: 19, Issue:5

    Topics: Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Delirium; Electrocardiography; Female; Halo

2015
Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial.
    Chest, 2015, Volume: 148, Issue:5

    Topics: Aged; Ancillary Services, Hospital; Circadian Rhythm; Delirium; Female; Follow-Up Studies; Humans; I

2015
The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial.
    Trials, 2016, Jan-28, Volume: 17

    Topics: Aged; Cardiac Surgical Procedures; Data Interpretation, Statistical; Delirium; Double-Blind Method;

2016
Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium.
    International psychogeriatrics, 2016, Volume: 28, Issue:7

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Cognition; Delirium; Double-Blind Metho

2016
Moderate dose melatonin for the abatement and treatment of delirium in elderly general medical inpatients: study protocol of a placebo controlled, randomised, double blind trial.
    BMC geriatrics, 2016, Feb-29, Volume: 16

    Topics: Administration, Oral; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Dose-Re

2016
Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial.
    Trials, 2017, 01-06, Volume: 18, Issue:1

    Topics: Administration, Oral; Clinical Protocols; Cost-Benefit Analysis; Critical Care; Delirium; Double-Bli

2017
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
    International journal of geriatric psychiatry, 2011, Volume: 26, Issue:7

    Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M

2011
The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial.
    BMC geriatrics, 2011, Jul-05, Volume: 11

    Topics: Aged; Delirium; Double-Blind Method; Female; Follow-Up Studies; Hip Fractures; Humans; Male; Melaton

2011

Other Studies

36 other studies available for melatonin and Delirium

ArticleYear
Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction.
    Annals of palliative medicine, 2021, Volume: 10, Issue:9

    Topics: Cognition Disorders; Delirium; Humans; Incidence; Melatonin; Postoperative Cognitive Complications

2021
Melatonin Administration Patterns for Pediatric Inpatients in a Tertiary Children's Hospital.
    Hospital pediatrics, 2021, Volume: 11, Issue:11

    Topics: Adult; Child; Delirium; Humans; Inpatients; Intensive Care Units; Melatonin; Retrospective Studies;

2021
Melatonin in ICU delirium: shining light on the hormone of darkness.
    Intensive care medicine, 2022, Volume: 48, Issue:4

    Topics: Darkness; Delirium; Humans; Intensive Care Units; Melatonin

2022
Melatonin for the prevention of postoperative delirium in older adults: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 09-23, Volume: 12, Issue:9

    Topics: Aged; Delirium; Humans; Incidence; Melatonin; Meta-Analysis as Topic; Review Literature as Topic; Sy

2022
[Sundowning of the elderly person].
    Revue medicale suisse, 2023, Sep-20, Volume: 19, Issue:842

    Topics: Aged; Circadian Rhythm; Delirium; Diagnosis, Differential; Existentialism; Humans; Melatonin

2023
Assessment of melatonergics in prevention of delirium in critically ill patients: A protocol for systematic review and meta-analysis.
    Medicine, 2020, Volume: 99, Issue:2

    Topics: Critical Illness; Delirium; Humans; Intensive Care Units; Length of Stay; Melatonin; Meta-Analysis a

2020
Relation of serum melatonin levels to postoperative delirium in older patients undergoing major abdominal surgery.
    The Journal of international medical research, 2020, Volume: 48, Issue:3

    Topics: Abdomen; Age Factors; Aged; Biomarkers; Critical Care; Delirium; Female; Humans; Male; Melatonin; Po

2020
Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients?
    Sleep medicine, 2020, Volume: 70

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Delirium, sleep, COVID-19 and melatonin.
    Sleep medicine, 2020, Volume: 75

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Reply to 'Delirium, sleep, COVID-19 and melatonin'.
    Sleep medicine, 2020, Volume: 75

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial.
    BMJ open, 2021, 02-12, Volume: 11, Issue:2

    Topics: Aged; Anesthesia, Conduction; Circadian Rhythm; Delirium; Hip Fractures; Humans; Melatonin; Postoper

2021
Delirium REduction after administration of melatonin in acute ischemic stroke (DREAMS): A propensity score-matched analysis.
    European journal of neurology, 2021, Volume: 28, Issue:6

    Topics: Brain Ischemia; Delirium; Humans; Ischemic Stroke; Melatonin; Propensity Score; Prospective Studies;

2021
Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon.
    The Annals of pharmacotherapy, 2021, Volume: 55, Issue:11

    Topics: Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Indenes; Intensive Care Units; Melatoni

2021
Pediatric COVID-19 Delirium: Case Report of 2 Adolescents.
    WMJ : official publication of the State Medical Society of Wisconsin, 2021, Volume: 120, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Antipsychotic Agents; COVID-19; Delirium; Drug The

2021
Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
    Mechanisms of ageing and development, 2017, Volume: 167

    Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Circadian Rhythm; Cognition Disorders; Delirium; Fe

2017
Role of Ramelteon in Reduction of As-Needed Antipsychotics in Elderly Patients with Delirium in a General Hospital Setting.
    Clinical drug investigation, 2017, Volume: 37, Issue:12

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Female; Hospitals, General; Humans; Inciden

2017
Delirium associated with only one dose of zopiclone in an older adult.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2018, Volume: 18, Issue:4

    Topics: Aged, 80 and over; Antioxidants; Azabicyclo Compounds; Delirium; Female; Humans; Hypnotics and Sedat

2018
Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality.
    Mayo Clinic proceedings, 2018, Volume: 93, Issue:12

    Topics: Aged; Antipsychotic Agents; Delirium; Female; Hospital Mortality; Humans; Intensive Care Units; Kapl

2018
Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium.
    Pharmacotherapy, 2019, Volume: 39, Issue:3

    Topics: Adult; Aged; Cohort Studies; Critical Illness; Delirium; Female; Humans; Intensive Care Units; Lengt

2019
Melatonin for sundown syndrome and delirium in dementia: is it effective?
    Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:6

    Topics: Aged, 80 and over; Alzheimer Disease; Central Nervous System Depressants; Delirium; Dose-Response Re

2013
Effectiveness of melatonin for sundown syndrome and delirium.
    Journal of the American Geriatrics Society, 2014, Volume: 62, Issue:2

    Topics: Alzheimer Disease; Delirium; Humans; Male; Melatonin

2014
[Research of 24-hour dynamic sleep monitoring and melatonin changes in patients with delirium in intensive care unit].
    Zhonghua wei zhong bing ji jiu yi xue, 2014, Volume: 26, Issue:10

    Topics: Biomedical Research; Case-Control Studies; Delirium; Humans; Intensive Care Units; Melatonin; Polyso

2014
The diurnal profile of melatonin during delirium in elderly patients--preliminary results.
    Experimental gerontology, 2015, Volume: 72

    Topics: Aged; Aged, 80 and over; Circadian Rhythm; Comorbidity; Delirium; Female; Hospitalization; Hospitals

2015
Melatonin Supplementation to Prevent Delirium in Hospitalized Elderly Patients.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2016, Volume: 69, Issue:6

    Topics: Aged; Central Nervous System Depressants; Delirium; Geriatric Assessment; Hospitalization; Humans; I

2016
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol.
    Systematic reviews, 2016, 11-24, Volume: 5, Issue:1

    Topics: Critical Care; Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Melatonin; Research Desi

2016
Pharmacological interventions for delirium in intensive care patients: a protocol for an overview of reviews.
    Systematic reviews, 2016, 12-07, Volume: 5, Issue:1

    Topics: Critical Care; Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Melatonin; Meta-Analysis

2016
Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Aged; Aged, 80 and over; Circadian Rhythm; Delirium; Female; Hip Fractures; Humans; Male; Melatonin;

2016
Melatonin and postoperative delirium: a possible link?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2010, Volume: 57, Issue:8

    Topics: Alcohol Withdrawal Delirium; Anesthesia Recovery Period; Delayed-Action Preparations; Delirium; Huma

2010
[Delirium, insomnia in hospitalization and ramelteon].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:5

    Topics: Delirium; Hospitalization; Humans; Indenes; Melatonin; Sleep Initiation and Maintenance Disorders

2012
Marked improvement in delirium with ramelteon: five case reports.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2012, Volume: 12, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Circadian Rhythm; Delirium; Female; Humans; Indenes; Mal

2012
Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium.
    Journal of critical care, 2013, Volume: 28, Issue:3

    Topics: Aged; APACHE; Chi-Square Distribution; Comorbidity; Critical Illness; Delirium; Female; Humans; Inte

2013
The relation between the clinical subtypes of delirium and the urinary level of 6-SMT.
    The Journal of neuropsychiatry and clinical neurosciences, 2003,Summer, Volume: 15, Issue:3

    Topics: Aged; Aged, 80 and over; Comorbidity; Delirium; Female; Geriatric Assessment; Humans; International

2003
Postoperative delirium: the tryptophan dyregulation model.
    Medical hypotheses, 2004, Volume: 63, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Brain; Delirium; Humans; Melatonin; Models, Neurological; Postoperat

2004
Postoperative delirium, plasma melatonin, and light.
    Medical hypotheses, 2001, Volume: 56, Issue:3

    Topics: Circadian Rhythm; Delirium; Humans; Light; Melatonin; Postoperative Complications

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Melatonin for treatment and prevention of postoperative delirium.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:2

    Topics: Aged; Delirium; Humans; Male; Melatonin; Middle Aged; Postoperative Complications

2002