melatonin has been researched along with Degenerative Disc Disease in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " N-acetyl-5-methoxytryptamine (melatonin) is a natural hormone secreted by the pineal gland which has been shown to participate in several physiological and pathological progresses, such as aging, anti-inflammation, anti-apoptosis and autophagy regulation." | 7.91 | Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. ( Chen, Z; Han, Y; He, F; Qian, L; Su, Q; Tan, J; Yan, M; Zhang, Q; Zhang, Y, 2019) |
| "Intervertebral disc degeneration (IDD) is a complicated disease in patients." | 5.51 | Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition. ( Chen, J; Chen, X; Chen, Y; Shi, H; Wang, J; Wang, X; Wu, Y; Xiao, J; Xu, D; Zhang, Z; Zheng, Z, 2019) |
| "This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF-κB signaling pathway." | 3.96 | Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc. ( Chen, F; Li, Z; Liu, H; Pei, Y; Wang, J; Wang, X; Zhang, J; Zheng, Z, 2020) |
| " N-acetyl-5-methoxytryptamine (melatonin) is a natural hormone secreted by the pineal gland which has been shown to participate in several physiological and pathological progresses, such as aging, anti-inflammation, anti-apoptosis and autophagy regulation." | 3.91 | Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. ( Chen, Z; Han, Y; He, F; Qian, L; Su, Q; Tan, J; Yan, M; Zhang, Q; Zhang, Y, 2019) |
| "Melatonin is reportedly associated with intervertebral disc degeneration (IDD)." | 3.91 | Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway. ( Chen, T; Gao, W; Jin, H; Lin, J; Nisar, M; Tian, N; Wang, C; Wang, Q; Wang, X; Wu, Y; Xu, T; Zhang, X; Zhang, Z; Zheng, G; Zhou, Y, 2019) |
| "Melatonin is a pleiotropic indole hormone secreted by the pineal gland and plays an important role in resisting various degenerative diseases." | 2.72 | The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review. ( Cheng, Z; Wang, J; Xiang, Q; Zhang, Y, 2021) |
| "Intervertebral disc degeneration (IDD) is a complicated disease in patients." | 1.51 | Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition. ( Chen, J; Chen, X; Chen, Y; Shi, H; Wang, J; Wang, X; Wu, Y; Xiao, J; Xu, D; Zhang, Z; Zheng, Z, 2019) |
| "Melatonin treatment significantly inhibited NP cell proliferation in dose-dependent manner." | 1.46 | Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway. ( Chan, MTV; Chen, C; Li, X; Li, Z; Shen, J; Wu, WKK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hemati, K | 1 |
| Pourhanifeh, MH | 1 |
| Fatemi, I | 1 |
| Hosseinzadeh, A | 1 |
| Mehrzadi, S | 1 |
| Dou, X | 1 |
| Ma, Y | 2 |
| Luo, Q | 1 |
| Song, C | 1 |
| Liu, M | 1 |
| Liu, X | 3 |
| Jia, D | 1 |
| Li, S | 1 |
| Zhang, Y | 2 |
| He, F | 1 |
| Chen, Z | 1 |
| Su, Q | 1 |
| Yan, M | 1 |
| Zhang, Q | 1 |
| Tan, J | 1 |
| Qian, L | 1 |
| Han, Y | 1 |
| Ge, J | 1 |
| Zhou, Q | 1 |
| Niu, J | 1 |
| Wang, Y | 1 |
| Yan, Q | 1 |
| Wu, C | 1 |
| Qian, J | 1 |
| Yang, H | 1 |
| Zou, J | 1 |
| Chen, F | 1 |
| Liu, H | 1 |
| Wang, X | 3 |
| Li, Z | 2 |
| Zhang, J | 1 |
| Pei, Y | 1 |
| Zheng, Z | 2 |
| Wang, J | 3 |
| Cheng, Z | 1 |
| Xiang, Q | 1 |
| Li, X | 1 |
| Chen, C | 1 |
| Chan, MTV | 1 |
| Wu, WKK | 1 |
| Shen, J | 1 |
| Zhang, Z | 2 |
| Lin, J | 1 |
| Tian, N | 1 |
| Wu, Y | 2 |
| Zhou, Y | 1 |
| Wang, C | 1 |
| Wang, Q | 1 |
| Jin, H | 1 |
| Chen, T | 1 |
| Nisar, M | 1 |
| Zheng, G | 1 |
| Xu, T | 1 |
| Gao, W | 1 |
| Zhang, X | 1 |
| Chen, Y | 1 |
| Shi, H | 1 |
| Chen, J | 1 |
| Chen, X | 1 |
| Xu, D | 1 |
| Xiao, J | 1 |
| Hai, B | 1 |
| Pan, X | 1 |
| Yong, L | 1 |
| Liang, C | 1 |
| He, G | 1 |
| Yang, C | 1 |
| Zhu, B | 1 |
1 review available for melatonin and Degenerative Disc Disease
| Article | Year |
|---|---|
The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review.
Topics: Aged; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Melatonin; Nucleus Pulposus | 2021 |
9 other studies available for melatonin and Degenerative Disc Disease
| Article | Year |
|---|---|
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy.
Topics: Apoptosis; Autophagy; Humans; Inflammation; Intervertebral Disc; Intervertebral Disc Degeneration; M | 2022 |
Therapeutic potential of melatonin in the intervertebral disc degeneration through inhibiting the ferroptosis of nucleus pulpous cells.
Topics: Culture Media, Conditioned; Ferroptosis; Humans; Intervertebral Disc Degeneration; Iron; Iron Overlo | 2023 |
Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.
Topics: Animals; Extracellular Matrix; Female; Humans; Inflammation; Interleukin-1beta; Intervertebral Disc | 2019 |
Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Collagen Type II; Disease Models, Animal; Humans; Inte | 2019 |
Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc.
Topics: Adolescent; Adult; Aged; Animals; Annulus Fibrosus; Antioxidants; Autophagy; Disease Models, Animal; | 2020 |
Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway.
Topics: Aggrecans; Cell Proliferation; Collagen Type II; Extracellular Matrix; Humans; Intervertebral Disc D | 2017 |
Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway.
Topics: Animals; Apoptosis; Autophagy; Calcinosis; Carbazoles; Cells, Cultured; Chondrocytes; Disease Models | 2019 |
Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Intervertebral Disc Degeneration; Male; Melatonin | 2019 |
Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway.
Topics: Annulus Fibrosus; Antioxidants; Apoptosis; Autophagy-Related Protein 7; Cell Proliferation; Cells, C | 2019 |