melatonin has been researched along with Deficiency, Mental in 32 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity." | 9.14 | Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. ( Braam, W; Curfs, LM; Didden, R; Korzilius, H; Maas, AP; Smits, MG, 2010) |
| "Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use." | 8.84 | Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007) |
| "7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response." | 7.81 | Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. ( Ayyash, HF; Cortese, S; Morton, R; Preece, P, 2015) |
| "Our data indicate a disturbed circadian rhythm in melatonin and document the disturbed sleep pattern in Smith-Magenis syndrome." | 7.70 | Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome. ( Glaze, D; Kashork, CD; Lupski, JR; Park, SS; Potocki, L; Reiter, RJ; Shaffer, LG; Tan, DX, 2000) |
| "Melatonin treatment improves some aspects of chronic sleep disturbance in individuals with ID." | 6.73 | Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. ( Braam, W; Curfs, L; Didden, R; Smits, M, 2008) |
| "Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime." | 6.71 | Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004) |
| "Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11." | 6.43 | Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. ( De Leersnyder, H, 2006) |
| "Treatment with melatonin demonstrated efficacy, suggesting that, at least in a subgroup of patients, the endogenous melatonin level may not be sufficient to adequately set the sleep-wake cycles." | 5.37 | Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. ( Botros, HG; Bourgeron, T; Briault, S; Chelly, J; de Brouwer, A; Delorme, R; Dumaine, A; Jamain, S; Kalscheuer, V; Lacombe, D; Laumonnier, F; Launay, JM; Leboyer, M; Moreno, S; Pagan, C; Poirier, K; Raynaud, M; Tzschach, A; van Bon, BW; Van Esch, H; Willemsen, MH, 2011) |
| "Mental retardation is constant; there are major behavioral disturbances and severe sleep disorders." | 5.32 | [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. ( Bresson, JL; Claustrat, B; de Blois, MC; De Leersnyder, H; Munnich, A; Sidi, D, 2003) |
| "Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity." | 5.14 | Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. ( Braam, W; Curfs, LM; Didden, R; Korzilius, H; Maas, AP; Smits, MG, 2010) |
| "Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use." | 4.84 | Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007) |
| " This article focuses on the following specific neurologic diseases: nocturnal frontal lobe epilepsy and abnormal motor behaviors of epileptic origin, evaluating differential diagnosis with parasomnias; achondroplasia, confirming the crucial role of craniofacial deformity in determining sleep-disordered breathing; neuromuscular diseases, mainly Duchenne's muscular dystrophy and myotonic dystrophy; cerebral palsy, evaluating either the features of sleep architecture and the importance of the respiratory problems associated; headaches, confirming the strict relationships with sleep in terms of neurochemical and neurobehavioral substrates; and finally a review on the effectiveness of melatonin for sleep problems in children with neurologic syndromes and mental retardation, blindness, and epilepsy." | 4.81 | Sleep disorders in children with neurologic diseases. ( Bruni, O; Zucconi, M, 2001) |
| "7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response." | 3.81 | Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. ( Ayyash, HF; Cortese, S; Morton, R; Preece, P, 2015) |
| "In this study, we determined melatonin clearance in two female (aged 61 and 6 years) and one male (aged 3 years) patients who had chronic insomnia, late melatonin onset and mild ID, and whose sleep quality worsened a few weeks after initial good response to melatonin treatment, suggesting melatonin tolerance." | 3.76 | Loss of response to melatonin treatment is associated with slow melatonin metabolism. ( Braam, W; Curfs, LM; Didden, R; Keijzer, H; Smits, MG; van Geijlswijk, I, 2010) |
| "Our data indicate a disturbed circadian rhythm in melatonin and document the disturbed sleep pattern in Smith-Magenis syndrome." | 3.70 | Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome. ( Glaze, D; Kashork, CD; Lupski, JR; Park, SS; Potocki, L; Reiter, RJ; Shaffer, LG; Tan, DX, 2000) |
| "Melatonin treatment improves some aspects of chronic sleep disturbance in individuals with ID." | 2.73 | Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. ( Braam, W; Curfs, L; Didden, R; Smits, M, 2008) |
| "Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime." | 2.71 | Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004) |
| "Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11." | 2.43 | Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. ( De Leersnyder, H, 2006) |
| "Treatment with melatonin demonstrated efficacy, suggesting that, at least in a subgroup of patients, the endogenous melatonin level may not be sufficient to adequately set the sleep-wake cycles." | 1.37 | Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. ( Botros, HG; Bourgeron, T; Briault, S; Chelly, J; de Brouwer, A; Delorme, R; Dumaine, A; Jamain, S; Kalscheuer, V; Lacombe, D; Laumonnier, F; Launay, JM; Leboyer, M; Moreno, S; Pagan, C; Poirier, K; Raynaud, M; Tzschach, A; van Bon, BW; Van Esch, H; Willemsen, MH, 2011) |
| "Mental retardation is constant; there are major behavioral disturbances and severe sleep disorders." | 1.32 | [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. ( Bresson, JL; Claustrat, B; de Blois, MC; De Leersnyder, H; Munnich, A; Sidi, D, 2003) |
| "Melatonin treatment increased nighttime sleep from 5." | 1.31 | Melatonin improves sleep-wake patterns in psychomotor retarded children. ( Etzioni, A; Lavie, P; Peled, N; Pillar, G; Ravid, S; Shahar, E, 2000) |
| "Melatonin is a well-tolerated, safe, relatively inexpensive, and effective drug, with minimal side effects, for the treatment of severe circadian rhythm sleep disorder in handicapped children." | 1.31 | Melatonin for the treatment of handicapped children with severe sleep disorders. ( Jan, MM, 2000) |
| "A 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24." | 1.28 | Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy. ( Blennow, G; Palm, L; Wetterberg, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 18 (56.25) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Won, J | 1 |
| Jin, Y | 1 |
| Choi, J | 1 |
| Park, S | 1 |
| Lee, TH | 1 |
| Lee, SR | 1 |
| Chang, KT | 1 |
| Hong, Y | 1 |
| Benabou, M | 1 |
| Rolland, T | 1 |
| Leblond, CS | 1 |
| Millot, GA | 1 |
| Huguet, G | 1 |
| Delorme, R | 2 |
| Leboyer, M | 2 |
| Pagan, C | 2 |
| Callebert, J | 1 |
| Maronde, E | 1 |
| Bourgeron, T | 2 |
| Albrecht, M | 1 |
| Zitta, K | 1 |
| Groenendaal, F | 1 |
| van Bel, F | 1 |
| Peeters-Scholte, C | 1 |
| Ayyash, HF | 1 |
| Preece, P | 1 |
| Morton, R | 1 |
| Cortese, S | 1 |
| McAdams, RM | 1 |
| Juul, SE | 1 |
| Hamers, PC | 1 |
| Evenhuis, HM | 1 |
| Hermans, H | 1 |
| Braam, W | 4 |
| Smits, MG | 3 |
| Didden, R | 4 |
| Korzilius, H | 2 |
| Van Geijlswijk, IM | 1 |
| Curfs, LM | 3 |
| Boudreau, EA | 1 |
| Johnson, KP | 1 |
| Jackman, AR | 1 |
| Blancato, J | 1 |
| Huizing, M | 1 |
| Bendavid, C | 1 |
| Jones, M | 1 |
| Chandrasekharappa, SC | 1 |
| Lewy, AJ | 1 |
| Smith, AC | 1 |
| Magenis, RE | 1 |
| Maas, AP | 1 |
| van Geijlswijk, I | 1 |
| Keijzer, H | 1 |
| Botros, HG | 1 |
| Poirier, K | 1 |
| Dumaine, A | 1 |
| Jamain, S | 1 |
| Moreno, S | 1 |
| de Brouwer, A | 1 |
| Van Esch, H | 1 |
| Launay, JM | 1 |
| Tzschach, A | 1 |
| Kalscheuer, V | 1 |
| Lacombe, D | 1 |
| Briault, S | 1 |
| Laumonnier, F | 1 |
| Raynaud, M | 1 |
| van Bon, BW | 1 |
| Willemsen, MH | 1 |
| Chelly, J | 1 |
| Niederhofer, H | 1 |
| Staffen, W | 1 |
| Mair, A | 1 |
| Pittschieler, K | 1 |
| Cornélissen, G | 1 |
| Halberg, F | 1 |
| Tarquini, R | 1 |
| Perfetto, F | 1 |
| Salti, R | 1 |
| Laffi, G | 1 |
| Otsuka, K | 1 |
| De Leersnyder, H | 2 |
| de Blois, MC | 1 |
| Bresson, JL | 1 |
| Sidi, D | 1 |
| Claustrat, B | 1 |
| Munnich, A | 1 |
| Coppola, G | 1 |
| Iervolino, G | 1 |
| Mastrosimone, M | 1 |
| La Torre, G | 1 |
| Ruiu, F | 1 |
| Pascotto, A | 1 |
| Wheeler, B | 1 |
| Taylor, B | 1 |
| Simonsen, K | 1 |
| Reith, DM | 1 |
| Sajith, SG | 1 |
| Clarke, D | 1 |
| Bersani, G | 1 |
| Russo, D | 1 |
| Limpido, L | 1 |
| Marconi, D | 1 |
| Laakso, ML | 1 |
| Lindblom, N | 1 |
| Leinonen, L | 1 |
| Kaski, M | 1 |
| Smits, M | 1 |
| Curfs, L | 1 |
| Dodd, A | 1 |
| Hare, DJ | 1 |
| Arshad, P | 1 |
| Ito, J | 1 |
| Saijo, H | 1 |
| Tanaka, H | 1 |
| Tasaki, T | 1 |
| Chou, K | 1 |
| Camfield, P | 1 |
| Gordon, K | 1 |
| Dooley, J | 1 |
| Camfield, C | 1 |
| Lancioni, GE | 1 |
| O'Reilly, MF | 1 |
| Basili, G | 1 |
| Potocki, L | 1 |
| Glaze, D | 1 |
| Tan, DX | 1 |
| Park, SS | 1 |
| Kashork, CD | 1 |
| Shaffer, LG | 1 |
| Reiter, RJ | 1 |
| Lupski, JR | 1 |
| Pillar, G | 1 |
| Shahar, E | 1 |
| Peled, N | 1 |
| Ravid, S | 1 |
| Lavie, P | 1 |
| Etzioni, A | 1 |
| Jan, MM | 1 |
| Akaboshi, S | 1 |
| Inoue, Y | 1 |
| Kubota, N | 1 |
| Takeshita, K | 1 |
| Zucconi, M | 1 |
| Bruni, O | 1 |
| Palm, L | 1 |
| Blennow, G | 1 |
| Wetterberg, L | 1 |
| Woolley, DW | 1 |
| Van der Hoeven, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth[NCT03897101] | 150 participants (Anticipated) | Observational [Patient Registry] | 2019-03-01 | Recruiting | |||
| Use of Melatonin for Neuroprotection in Term Infants With Hypoxic-ischaemic Encephalopathy[NCT03806816] | 100 participants (Anticipated) | Interventional | 2018-12-13 | Recruiting | |||
| Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD).[NCT01033565] | Phase 4 | 1 participants (Actual) | Interventional | 2010-03-04 | Terminated (stopped due to Unsuccessful in recruiting appropriate subjects.) | ||
| Melatonin Levels in Sleep-disordered Smith-Magenis Syndrome: a Pilot Study[NCT00691574] | 5 participants (Actual) | Interventional | 1998-09-30 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080] | 58 participants (Actual) | Observational | 2007-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assigns numerical score indicating level of improvement compared to baseline. Scale is rated from 1-7: 1= very much improved; 2= much improved; 3= minimally improved; 4= no change; 5= minimally worse; 6= much worse; 7= very much worse. (NCT01033565)
Timeframe: 2 weeks
| Intervention | units on a scale (Number) |
|---|---|
| Natrol | 2 |
8 reviews available for melatonin and Deficiency, Mental
| Article | Year |
|---|---|
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation | 2017 |
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythr | 2019 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2009 |
Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment.
Topics: Abnormalities, Multiple; Circadian Rhythm; Humans; Intellectual Disability; Melatonin; Sleep Wake Di | 2006 |
Melatonin and sleep disorders associated with intellectual disability: a clinical review.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Dr | 2007 |
Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps.
Topics: Adolescent; Adult; Behavior Therapy; Child; Chronotherapy; Developmental Disabilities; Female; Human | 1999 |
Sleep disorders in children with neurologic diseases.
Topics: Anticonvulsants; Blindness; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Headache; Hu | 2001 |
7 trials available for melatonin and Deficiency, Mental
| Article | Year |
|---|---|
A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression: Study protocol and obstacle management.
Topics: Actigraphy; Adult; Circadian Rhythm; Depression; Depressive Disorder, Major; Hair; Humans; Hydrocort | 2017 |
Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Circadian Rhythm; Female; Humans; Intel | 2010 |
Brief report: melatonin facilitates sleep in individuals with mental retardation and insomnia.
Topics: Administration, Oral; Adolescent; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admini | 2003 |
Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Cros | 2004 |
Melatonin treatment in Smith Magenis syndrome.
Topics: Antioxidants; Chronobiology Disorders; Double-Blind Method; Humans; Intellectual Disability; Melaton | 2005 |
Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Child; Child, Preschool; Chronic Diseas | 2008 |
Melatonin appears ineffective in children with intellectual deficits and fragmented sleep: six "N of 1" trials.
Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Intellectual Disability; M | 1996 |
17 other studies available for melatonin and Deficiency, Mental
| Article | Year |
|---|---|
Heritability of the melatonin synthesis variability in autism spectrum disorders.
Topics: Adolescent; Adult; Arylalkylamine N-Acetyltransferase; Autism Spectrum Disorder; Child; Endophenotyp | 2017 |
Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study.
Topics: Analysis of Variance; Central Nervous System Depressants; Child; Child, Preschool; Dose-Response Rel | 2015 |
Review of disrupted sleep patterns in Smith-Magenis syndrome and normal melatonin secretion in a patient with an atypical interstitial 17p11.2 deletion.
Topics: Abnormalities, Multiple; Chromosome Deletion; Chromosomes, Human, Pair 17; Female; Humans; Intellect | 2009 |
Loss of response to melatonin treatment is associated with slow melatonin metabolism.
Topics: Child; Child, Preschool; Drug Tolerance; Female; Humans; Intellectual Disability; Male; Melatonin; M | 2010 |
Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.
Topics: Acetylserotonin O-Methyltransferase; Case-Control Studies; Genetic Testing; Humans; Intellectual Dis | 2011 |
Point and interval estimations of circadian melatonin ecphasia in Smith-Magenis syndrome.
Topics: Adolescent; Adult; Child; Chromosome Deletion; Chromosomes, Human, Pair 17; Congenital Abnormalities | 2003 |
[Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome].
Topics: Abnormalities, Multiple; Adolescent; Adrenergic beta-Antagonists; Child; Child, Preschool; Chromosom | 2003 |
Mood disorder in a patient with Smith-Magenis syndrome: a case report.
Topics: Adult; Chromosomes, Human, Pair 17; Craniofacial Abnormalities; Female; Gene Deletion; Humans; Intel | 2007 |
Endogenous melatonin predicts efficacy of exogenous melatonin in consolidation of fragmented wrist-activity rhythm of adult patients with developmental brain disorders: a double-blind, placebo-controlled, crossover study.
Topics: Adult; Circadian Rhythm; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; | 2007 |
The use of melatonin to treat sleep disorder in adults with intellectual disabilities in community settings - the evaluation of three cases using actigraphy.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hu | 2008 |
[Melatonin treatment for sleep-wake disorder--an experience for a severely mental retarded patient with blindness].
Topics: Administration, Oral; Blindness; Child; Circadian Rhythm; Humans; Intellectual Disability; Male; Mel | 1995 |
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 17; Ci | 2000 |
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 17; Ci | 2000 |
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 17; Ci | 2000 |
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 17; Ci | 2000 |
Melatonin improves sleep-wake patterns in psychomotor retarded children.
Topics: Adolescent; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Intellectual Disability; Male | 2000 |
Melatonin for the treatment of handicapped children with severe sleep disorders.
Topics: Child; Child, Preschool; Circadian Rhythm; Disabled Children; Drug Administration Schedule; Female; | 2000 |
Case of a mentally retarded child with non-24 hour sleep-wake syndrome caused by deficiency of melatonin secretion.
Topics: Administration, Oral; Child, Preschool; Humans; Hydrocortisone; Intellectual Disability; Male; Melat | 2000 |
Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy.
Topics: Blindness; Child; Circadian Rhythm; Humans; Hydrocortisone; Intellectual Disability; Male; Melatonin | 1991 |
Serotonin deficiency in infancy as a cause of a mental defect in experimental phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Chlorpromazine; Electroshock; Female; Humans; In Vit | 1965 |