Page last updated: 2024-10-19

melatonin and Daytime Sleepiness

melatonin has been researched along with Daytime Sleepiness in 41 studies

Research Excerpts

ExcerptRelevanceReference
"To determine the relationship between the timing and amplitude of the 24-hour melatonin rhythm, a marker of endogenous circadian rhythmicity, with self-reported sleep quality, the severity of daytime sleepiness, and disease metrics."7.80Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. ( Marconi, A; Noble, C; Peng, J; Rademaker, AW; Reid, KJ; Simuni, T; Turek, FW; Videnovic, A; Zadikoff, C; Zee, PC, 2014)
"To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality."7.80Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014)
" Because hypothalamic lesions may explain daytime sleepiness in craniopharyngioma patients, salivary melatonin and cortisol concentrations were examined in severely obese (BMI>or=4SD) and non severely obese (BMI<4SD) craniopharyngioma patients (n=79), patients with hypothalamic pilocytic astrocytoma (n=19), and control subjects (n=30)."7.73Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. ( Emser, A; Faldum, A; Gebhardt, U; Handwerker, G; Kolb, R; Müller, HL; Sörensen, N, 2006)
"Melatonin treatment significantly improved subjective sleep quality, as compared with placebo (p = 0."6.71Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. ( Campos, FL; da Silva-Júnior, FP; de Bruin, PF; de Bruin, VM, 2004)
"To determine the relationship between the timing and amplitude of the 24-hour melatonin rhythm, a marker of endogenous circadian rhythmicity, with self-reported sleep quality, the severity of daytime sleepiness, and disease metrics."3.80Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. ( Marconi, A; Noble, C; Peng, J; Rademaker, AW; Reid, KJ; Simuni, T; Turek, FW; Videnovic, A; Zadikoff, C; Zee, PC, 2014)
"To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality."3.80Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014)
" Because hypothalamic lesions may explain daytime sleepiness in craniopharyngioma patients, salivary melatonin and cortisol concentrations were examined in severely obese (BMI>or=4SD) and non severely obese (BMI<4SD) craniopharyngioma patients (n=79), patients with hypothalamic pilocytic astrocytoma (n=19), and control subjects (n=30)."3.73Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. ( Emser, A; Faldum, A; Gebhardt, U; Handwerker, G; Kolb, R; Müller, HL; Sörensen, N, 2006)
"The outcomes showed decreased daytime sleepiness, lessened sleep onset latency, diminished night-time awakenings, increased total sleep period and improved daytime attention in the melatonin-treated group; (4) Conclusions: Exogenously administered melatonin is effective in shift worker health personnel that are suffering from sleep disorders, and given its low adverse effects and tolerability, it might be recommended."2.82The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. ( Cantón-Manzano, C; Carriedo-Diez, B; Sanz-Valero, J; Tosoratto-Venturi, JL; Wanden-Berghe, C, 2022)
"Melatonin treatment significantly improved subjective sleep quality, as compared with placebo (p = 0."2.71Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. ( Campos, FL; da Silva-Júnior, FP; de Bruin, PF; de Bruin, VM, 2004)
"Six patients improved after sleep deprivation (> or =50% reduction on SIGH-SAD(22) score)."2.71Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates. ( Danilenko, KV; Putilov, AA, 2005)
"While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions."2.61Sleep Disorders. ( K Pavlova, M; Latreille, V, 2019)
"Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment."2.44A clinical approach to circadian rhythm sleep disorders. ( Barion, A; Zee, PC, 2007)
"Circadian rhythm sleep disorders are perhaps the most often overlooked conditions in the differential diagnosis of these symptoms."2.44Diagnosis of circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D; Menna-Barreto, L, 2008)
"We also characterized mood states, daytime sleepiness, and sleep quality by questionnaires."1.91Sleep impairment and altered pattern of circadian biomarkers during a long-term Antarctic summer camp. ( Arantes, RME; Borges, L; Gonçalves, DAP; Hatanaka, E; Heller, D; Marques, AL; Mendes, TT; Moraes, MM; Núñez-Espinosa, C; Soares, DD; Wanner, SP, 2023)
"To characterize and compare insomnia symptoms within two common phenotypes of Shift Work Disorder."1.42Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder. ( Belcher, R; Drake, CL; Gumenyuk, V; Roth, T, 2015)
"Before treatment, the patient had mild hypersomnia with long sleep time (704 min), ultradian sleep-wake rhythm (sleep occurred every 11."1.36Sleep and rhythm consequences of a genetically induced loss of serotonin. ( Arnulf, I; Boniol, C; Clot, F; Decaix, C; Leu-Semenescu, S; Levy, R; Moussa, F; Roze, E; Touitou, Y; Vidailhet, M, 2010)
"Disturbed sleep and/or hypersomnia are direct consequences of shift work and therefore described as shift work disorder."1.36[Burden and health effects of shift work]. ( Heitmann, J, 2010)
"Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent."1.32Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003)
"Recurrent hypersomnia is characterized by recurring episodes of hypersomnia of 18 h or more per day lasting from several days to several weeks."1.32Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia. ( Hamada, A; Joudoi, T; Kawatani, J; Miike, T; Ohmura, T; Tomoda, A; Tonooka, S, 2003)
"Rapid eye movement sleep deprivation had no impact on circulating L-PGDS levels."1.32Prostaglandin D synthase (beta-trace) in healthy human sleep. ( Brunner, E; Cohrs, S; Eggert, S; Hajak, G; Jordan, W; Rodenbeck, A; Rüther, E; Tumani, H, 2004)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.44)18.7374
1990's4 (9.76)18.2507
2000's20 (48.78)29.6817
2010's12 (29.27)24.3611
2020's4 (9.76)2.80

Authors

AuthorsStudies
Ammar, N1
Attarian, H1
Wilson, A1
Carriedo-Diez, B1
Tosoratto-Venturi, JL1
Cantón-Manzano, C1
Wanden-Berghe, C1
Sanz-Valero, J1
Moraes, MM1
Marques, AL1
Borges, L1
Hatanaka, E1
Heller, D1
Núñez-Espinosa, C1
Gonçalves, DAP1
Soares, DD1
Wanner, SP1
Mendes, TT1
Arantes, RME1
Kennert, BA1
Harshorne, TS1
Kanouse, S1
Johnson, C1
K Pavlova, M1
Latreille, V1
Videnovic, A2
Noble, C1
Reid, KJ1
Peng, J1
Turek, FW1
Marconi, A1
Rademaker, AW1
Simuni, T1
Zadikoff, C1
Zee, PC3
Pickering, L1
Jennum, P1
Gammeltoft, S1
Poulsgaard, L1
Feldt-Rasmussen, U1
Klose, M1
Duclos, C1
Dumont, M1
Wiseman-Hakes, C1
Arbour, C1
Mongrain, V1
Gaudreault, PO1
Khoury, S1
Lavigne, G1
Desautels, A1
Gosselin, N1
Boivin, DB1
Boudreau, P1
Gumenyuk, V1
Belcher, R1
Drake, CL1
Roth, T1
Fifel, K1
DeBoer, T1
Breen, DP1
Barker, RA1
Gagné, AM1
Bouchard, G1
Tremblay, P1
Sasseville, A1
Hébert, M1
Leu-Semenescu, S1
Arnulf, I1
Decaix, C1
Moussa, F1
Clot, F1
Boniol, C1
Touitou, Y1
Levy, R1
Vidailhet, M1
Roze, E1
Heitmann, J1
Kuźniar, TJ1
Kovačević-Ristanović, R1
Nierodzik, CL1
Smith, LC1
Carskadon, MA2
Acebo, C2
Olejniczak, PW1
Fisch, BJ1
Stores, G1
Tomoda, A1
Joudoi, T1
Kawatani, J1
Ohmura, T1
Hamada, A1
Tonooka, S1
Miike, T1
Phipps-Nelson, J1
Redman, JR1
Dijk, DJ1
Rajaratnam, SM1
Lowden, A2
Akerstedt, T2
Wibom, R1
Campos, FL1
da Silva-Júnior, FP1
de Bruin, VM1
de Bruin, PF1
Peres, MF1
Zukerman, E1
da Cunha Tanuri, F1
Moreira, FR1
Cipolla-Neto, J1
Jordan, W1
Tumani, H1
Cohrs, S1
Eggert, S1
Rodenbeck, A1
Brunner, E1
Rüther, E1
Hajak, G1
Crowley, SJ1
Lee, C1
Tseng, CY1
Fogg, LF1
Eastman, CI1
Danilenko, KV1
Putilov, AA1
Rüger, M1
Gordijn, MC1
Beersma, DG1
de Vries, B1
Daan, S1
Dagan, Y1
Ayalon, L1
Lockley, SW1
Evans, EE1
Scheer, FA1
Brainard, GC1
Czeisler, CA1
Aeschbach, D1
Müller, HL1
Handwerker, G1
Gebhardt, U1
Faldum, A1
Emser, A1
Kolb, R1
Sörensen, N1
Bjorvatn, B1
Stangenes, K1
Oyane, N1
Forberg, K1
Holsten, F1
Barion, A1
Lu, B1
Martinez, D1
Lenz, Mdo C1
Menna-Barreto, L1
Uchimura, N1
Sakurai, S1
Sakamoto, T1
Kotorii, T1
Nakamura, J1
Maeda, Y1
Tsuchiyama, Y1
Nakazawa, Y1
Lehmann, ED1
Cockerell, OC1
Rudge, P1
Partonen, T1
Vakkuri, O1
Lamberg-Allardt, C1
Lonnqvist, J1
Wolfson, AR1
Tzischinsky, O1
Seifer, R1
Yang, CM1
Spielman, AJ1
D'Ambrosio, P1
Serizawa, S1
Nunes, J1
Birnbaum, J1
Thompson, C1
Obrecht, R1
Franey, C1
Arendt, J1
Checkley, SA1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of the Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep: a Double-blind Randomized Controlled Trial[NCT05899972]50 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Feasibility Study of Adjunctive Bright Light Therapy (BLT) for Amelioration of Fatigue in Chinese Cancer Patients Admitted to a Palliative Care Unit[NCT04525924]42 participants (Anticipated)Interventional2020-08-01Recruiting
Effects of Bright Light Treatment on Daytime Sleepiness and Nocturnal Sleep in Patients With Parkinson's Disease[NCT01338649]27 participants (Actual)Interventional2007-11-30Completed
A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches[NCT00391755]Phase 44 participants (Actual)Interventional2006-10-31Terminated (stopped due to Failure to recruit necessary number of patients.)
Melatonin for Migraine Prevention (The MMP-study): A Randomized, Double-blind, Cross-over, Placebo-controlled Study of Melatonin in Prophylactic Treatment of Migraine[NCT00849511]Phase 248 participants (Actual)Interventional2009-02-28Completed
"Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316]Phase 231 participants (Actual)Interventional2015-05-31Completed
Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609]60 participants (Anticipated)Interventional2023-12-08Recruiting
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars[NCT01169233]25 participants (Actual)Interventional2008-08-31Completed
Regulating Mood and Suicidal Ideation With Morning Light Exposure Treatment[NCT05616819]480 participants (Anticipated)Interventional2023-03-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in the Epworth Sleepiness Scale (ESS) Scores Comparing the Bright Light Exposure With Dim-red Light Exposure.

ESS score range is 0-24; lower ESS scores indicate less daytime sleepiness; higher ESS scores indicate more severe sleepiness ESS will be taken and compared at screening and week 4 visits between the bright light exposure and dim-red light exposure groups. (NCT01338649)
Timeframe: baseline and 4 weeks

Interventionscore (Mean)
Bright White4.46
Dim Red Light1.77

Headache Diary Compliance Rate

Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study

InterventionParticipants (Count of Participants)
Melatonin11
Placebo10

Medication Adherence as Measured by Number of Openings Per Participant

eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"

InterventionMean Number of Openings (Mean)
Melatonin39
Placebo60

Number of Migraine/Migrainous Days Per 28 Day Period

Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment

Interventiondays (Mean)
Melatonin3.6
Placebo4.9

Number of Minutes to Sleep Onset

Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks

Interventionminutes (Mean)
Melatonin15.2
Placebo17.2

Reviews

8 reviews available for melatonin and Daytime Sleepiness

ArticleYear
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
    International journal of environmental research and public health, 2022, 08-17, Volume: 19, Issue:16

    Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sleep Disorder

2022
Sleep Disorders.
    The American journal of medicine, 2019, Volume: 132, Issue:3

    Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Chronobiology Disorders; Cogn

2019
Sleep and wake disturbances following traumatic brain injury.
    Pathologie-biologie, 2014, Volume: 62, Issue:5

    Topics: Blast Injuries; Brain Damage, Chronic; Brain Injuries; Chronobiology Disorders; Cognitive Behavioral

2014
Impacts of shift work on sleep and circadian rhythms.
    Pathologie-biologie, 2014, Volume: 62, Issue:5

    Topics: Accidents; Arousal; Automobile Driving; Cardiovascular Diseases; Circadian Rhythm; Circadian Rhythm

2014
[When a season means depression].
    Medecine sciences : M/S, 2010, Volume: 26, Issue:1

    Topics: Affect; Brain Chemistry; Catecholamines; Circadian Rhythm; Disorders of Excessive Somnolence; Foreca

2010
Medication for sleep-wake disorders.
    Archives of disease in childhood, 2003, Volume: 88, Issue:10

    Topics: Child; Disorders of Excessive Somnolence; Humans; Melatonin; Parasomnias; Sleep Disorders, Intrinsic

2003
A clinical approach to circadian rhythm sleep disorders.
    Sleep medicine, 2007, Volume: 8, Issue:6

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Health Knowledge, Attitudes, Practice; Humans;

2007
Diagnosis of circadian rhythm sleep disorders.
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2008, Volume: 34, Issue:3

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Phototherapy; Polysomnograph

2008

Trials

5 trials available for melatonin and Daytime Sleepiness

ArticleYear
Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance.
    Sleep, 2003, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Arousal; Circadian Rhythm; Disorders of Excessive Somnolence; Electroencephalogra

2003
Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance.
    Sleep, 2003, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Arousal; Circadian Rhythm; Disorders of Excessive Somnolence; Electroencephalogra

2003
Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance.
    Sleep, 2003, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Arousal; Circadian Rhythm; Disorders of Excessive Somnolence; Electroencephalogra

2003
Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance.
    Sleep, 2003, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Arousal; Circadian Rhythm; Disorders of Excessive Somnolence; Electroencephalogra

2003
Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study.
    American journal of respiratory and critical care medicine, 2004, Nov-01, Volume: 170, Issue:9

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Asthma; Disorders of Excessive Somnol

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin, 3 mg, is effective for migraine prevention.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Alopecia; Analgesics; Disorders of Excessive Somnolence; Female; Humans; Libido; Male; Melato

2004
Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Affect; Case-Control Studies; Disorders of Excessive Somnolence; Double-Blind Met

2005
Subjective and objective measures of adaptation and readaptation to night work on an oil rig in the North Sea.
    Sleep, 2006, Volume: 29, Issue:6

    Topics: Adaptation, Physiological; Adult; Antioxidants; Cross-Over Studies; Disorders of Excessive Somnolenc

2006

Other Studies

28 other studies available for melatonin and Daytime Sleepiness

ArticleYear
Daytime sleepiness and circadian rhythm disturbance due to pineal and pontine damage.
    Sleep medicine, 2022, Volume: 89

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Pineal Gland; Pons

2022
Sleep impairment and altered pattern of circadian biomarkers during a long-term Antarctic summer camp.
    Scientific reports, 2023, 09-25, Volume: 13, Issue:1

    Topics: Antarctic Regions; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sl

2023
Parent survey of sleep problems among children with CHARGE syndrome.
    Research in developmental disabilities, 2020, Volume: 101

    Topics: Adolescent; Anxiety; Central Nervous System Depressants; CHARGE Syndrome; Child; Child, Preschool; C

2020
Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease.
    JAMA neurology, 2014, Volume: 71, Issue:4

    Topics: Aged; Biomarkers; Circadian Rhythm; Cohort Studies; Cross-Sectional Studies; Disorders of Excessive

2014
Sleep-wake and melatonin pattern in craniopharyngioma patients.
    European journal of endocrinology, 2014, Volume: 170, Issue:6

    Topics: Adolescent; Adult; Aged; Circadian Rhythm; Craniopharyngioma; Cross-Sectional Studies; Disorders of

2014
Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder.
    Sleep, 2015, Jan-01, Volume: 38, Issue:1

    Topics: Alleles; Attention; Brain; Case-Control Studies; Circadian Rhythm; Disorders of Excessive Somnolence

2015
The central clock in patients with Parkinson disease.
    JAMA neurology, 2014, Volume: 71, Issue:11

    Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male;

2014
The central clock in patients with Parkinson disease--reply.
    JAMA neurology, 2014, Volume: 71, Issue:11

    Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male;

2014
Sleep and rhythm consequences of a genetically induced loss of serotonin.
    Sleep, 2010, Volume: 33, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Antidepressive Agents, Second-Generation; Consa

2010
[Burden and health effects of shift work].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2010, Volume: 45, Issue:10

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Germany; Health; Humans; Melatonin; Occupationa

2010
Free-running (non-entrained to 24-h period) circadian sleep disorder in a patient with obstructive sleep apnea, delayed sleep phase tendency, and lack of social interaction.
    Sleep & breathing = Schlaf & Atmung, 2012, Volume: 16, Issue:2

    Topics: Arousal; Circadian Rhythm; Comorbidity; Continuous Positive Airway Pressure; Disorders of Excessive

2012
Regulation of sleepiness in adolescents: update, insights, and speculation.
    Sleep, 2002, Sep-15, Volume: 25, Issue:6

    Topics: Adolescent; Circadian Rhythm; Disorders of Excessive Somnolence; History, 20th Century; Homeostasis;

2002
Sleep disorders.
    The Medical clinics of North America, 2003, Volume: 87, Issue:4

    Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord

2003
Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia.
    Chronobiology international, 2003, Volume: 20, Issue:5

    Topics: Adolescent; Body Temperature; Circadian Rhythm; Disorders of Excessive Somnolence; Gene Expression;

2003
Suppression of sleepiness and melatonin by bright light exposure during breaks in night work.
    Journal of sleep research, 2004, Volume: 13, Issue:1

    Topics: Adaptation, Physiological; Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Employment; F

2004
Prostaglandin D synthase (beta-trace) in healthy human sleep.
    Sleep, 2004, Aug-01, Volume: 27, Issue:5

    Topics: Adult; Circadian Rhythm; Cross-Over Studies; Disorders of Excessive Somnolence; Female; Humans; Intr

2004
Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.
    Sleep, 2004, Sep-15, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Arousal; Body Temperature; Circadian Rhythm; Cognition Disorders; Disorders of Ex

2004
Weak relationships between suppression of melatonin and suppression of sleepiness/fatigue in response to light exposure.
    Journal of sleep research, 2005, Volume: 14, Issue:3

    Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Fatigue; Female; Humans; Light; Male; Me

2005
Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:12

    Topics: Adolescent; Depressive Disorder; Diagnostic Errors; Disorders of Excessive Somnolence; Humans; Learn

2005
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness.
    Cancer causes & control : CCC, 2006, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Astrocytoma; Child; Child, Preschool; Circadian Rhythm; Craniopharyngioma; Disord

2006
New-onset insomnia in a middle-aged woman.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2007, Feb-15, Volume: 3, Issue:1

    Topics: Antioxidants; Chronobiology Disorders; Disorders of Excessive Somnolence; Female; Humans; Melatonin;

2007
Polysomnography and chronobiologic study on periodic hypersomnia.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adolescent; Body Temperature Regulation; Circadian Rhythm; Disorders of Excessive Somnolence; Female

1993
Somnolence associated with melatonin deficiency after pinealectomy.
    Lancet (London, England), 1996, Feb-03, Volume: 347, Issue:8997

    Topics: Adult; Disorders of Excessive Somnolence; Female; Humans; Melatonin; Pineal Gland; Pregnancy; Puerpe

1996
Effects of bright light on sleepiness, melatonin, and 25-hydroxyvitamin D(3) in winter seasonal affective disorder.
    Biological psychiatry, 1996, May-15, Volume: 39, Issue:10

    Topics: Adult; Disorders of Excessive Somnolence; Female; Humans; Light; Melatonin; Middle Aged; Saliva; Sea

1996
Adolescent sleep patterns, circadian timing, and sleepiness at a transition to early school days.
    Sleep, 1998, Dec-15, Volume: 21, Issue:8

    Topics: Adolescent; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male; Melatonin; Sl

1998
A single dose of melatonin prevents the phase delay associated with a delayed weekend sleep pattern.
    Sleep, 2001, May-01, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Affect; Arousal; Circadian Rhythm; Cognition; Disorders of Excessive Somnolence;

2001
Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 147

    Topics: Adolescent; Circadian Rhythm; Disorders of Excessive Somnolence; Feeding and Eating Disorders; Femal

1985