melatonin has been researched along with Critical Illness in 46 studies
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was no significant difference in the average proportion of delirium-free assessments per patient between the melatonin and placebo groups (79." | 9.51 | Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial. ( Anstey, M; Chapman, A; Ford, A; Hawkins, D; Ho, KM; Kelty, E; Litton, E; Martinez, FE; McCaffrey, J; Murray, K; Myers, E; Rashid, A; Regli, A; van Haren, FMP; Wibrow, B; Wyer, S, 2022) |
| "Sepsis is defined as a dysregulated host response to infection, and high-dose melatonin has been proposed as a treatment due to its antioxidant and anti-inflammatory properties." | 9.51 | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis. ( Allen, L; Colin, PJ; Galley, HF; Galt, SP; Webster, NR, 2022) |
| "To compare the effect of prophylactic administration of melatonin, ramelteon, or no melatonin receptor agonist on the development of delirium in the intensive care unit (ICU)." | 8.02 | Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon. ( DeGrado, JR; Dube, KM; Lupi, KE; Romero, N, 2021) |
| "The development of ICU delirium was significantly lower in the melatonin group compared with that in the control group." | 7.91 | Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. ( Barnett, M; Baumgartner, L; Gross, K; Lai, J; Lam, K; Morris, A; Thompson, A, 2019) |
| "Delta melatonin concentration at 1 hour after the operation has a significant independent association with risk of postoperative delirium." | 7.79 | Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium. ( Egi, M; Kanazawa, T; Morimatsu, H; Morita, K; Toda, Y; Yoshitaka, S, 2013) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 7.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| "Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes." | 6.84 | Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study. ( Azad, A; Bernard, F; Burry, L; Detsky, M; Fan, E; Foster, J; Guenette, M; Mehta, S; Rose, L; Scales, D; Williamson, D, 2017) |
| "Intensive care delirium is a well-recognized complication in critically ill patients." | 6.48 | Potential use of melatonin in sleep and delirium in the critically ill. ( Bellapart, J; Boots, R, 2012) |
| "Improvements in encephalopathy and medical stabilization did not rapidly normalize rhythms." | 5.56 | Factors Disrupting Melatonin Secretion Rhythms During Critical Illness. ( Abbott, SM; Eed, J; Gendy, M; Liotta, EM; Lizza, BD; Maas, MB; Naidech, AM; Reid, KJ; Zee, PC, 2020) |
| " There was no significant difference in the average proportion of delirium-free assessments per patient between the melatonin and placebo groups (79." | 5.51 | Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial. ( Anstey, M; Chapman, A; Ford, A; Hawkins, D; Ho, KM; Kelty, E; Litton, E; Martinez, FE; McCaffrey, J; Murray, K; Myers, E; Rashid, A; Regli, A; van Haren, FMP; Wibrow, B; Wyer, S, 2022) |
| "Sepsis is defined as a dysregulated host response to infection, and high-dose melatonin has been proposed as a treatment due to its antioxidant and anti-inflammatory properties." | 5.51 | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis. ( Allen, L; Colin, PJ; Galley, HF; Galt, SP; Webster, NR, 2022) |
| "Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal." | 5.43 | Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol. ( Burry, LD; Cheung, A; Chimunda, T; Choong, K; Duffett, M; Foster, J; Guenette, M; Menon, K; Rose, L; Thabane, L, 2016) |
| "Thirteen patients in the recovery phase of critical illness were randomised to receive enteral melatonin or placebo." | 5.22 | Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients. ( Appadurai, V; Bellapart, J; Boots, RJ; Nuñez-Nuñez, M; Roberts, JA; Wallis, SC, 2016) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "To compare the effect of prophylactic administration of melatonin, ramelteon, or no melatonin receptor agonist on the development of delirium in the intensive care unit (ICU)." | 4.02 | Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon. ( DeGrado, JR; Dube, KM; Lupi, KE; Romero, N, 2021) |
| "Total daily and diurnal variation of 6-sulfatoxymelatonin excretion is heterogeneously maintained early in pediatric critical illness." | 3.96 | Total Daily Production and Periodicity of Melatonin Metabolite in Critically Ill Children. ( Foster, JR; Fraser, DD; Miller, MR; Seabrook, JA; Tijssen, JA, 2020) |
| "The development of ICU delirium was significantly lower in the melatonin group compared with that in the control group." | 3.91 | Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. ( Barnett, M; Baumgartner, L; Gross, K; Lai, J; Lam, K; Morris, A; Thompson, A, 2019) |
| "Delta melatonin concentration at 1 hour after the operation has a significant independent association with risk of postoperative delirium." | 3.79 | Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium. ( Egi, M; Kanazawa, T; Morimatsu, H; Morita, K; Toda, Y; Yoshitaka, S, 2013) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 3.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| " μE-TD presented a delayed time-to-peak blood concentration (4 hours), a lower bioavailability (AUC: 3142 [1344-14573] pg/mL*hours) and reached pharmacological peak concentration (388 [132-1583] pg/mL)." | 2.90 | Different routes and formulations of melatonin in critically ill patients. A pharmacokinetic randomized study. ( Chiumello, D; Coppola, S; Finati, E; Froio, S; Gasco, P; Iapichino, G; Manca, D; Mistraletti, G; Moro Salihovic, B; Paroni, R; Reiter, RJ; Savoca, A; Umbrello, M, 2019) |
| "Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes." | 2.84 | Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study. ( Azad, A; Bernard, F; Burry, L; Detsky, M; Fan, E; Foster, J; Guenette, M; Mehta, S; Rose, L; Scales, D; Williamson, D, 2017) |
| "Melatonin treated patients received lower amount of enteral hydroxyzine." | 2.80 | Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial. ( Cerri, B; D'Agostino, A; Formenti, P; Fraschini, F; Iapichino, G; Mantovani, ES; Miori, S; Mistraletti, G; Morabito, A; Reiter, RJ; Sabbatini, G; Salini, S; Spanu, P; Taverna, M; Umbrello, M, 2015) |
| "Sleep deprivation is common in critically ill patients in intensive care units (ICU)." | 2.79 | Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial. ( Cheng, J; Huang, H; Jiang, L; Shen, L; Xi, X; Zhang, G; Zhu, B, 2014) |
| "Melatonin use was associated with a 1-hour increase in nocturnal sleep (SEI difference = 0." | 2.73 | Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial. ( Bourne, RS; Mills, GH; Minelli, C, 2008) |
| "Intensive care delirium is a well-recognized complication in critically ill patients." | 2.48 | Potential use of melatonin in sleep and delirium in the critically ill. ( Bellapart, J; Boots, R, 2012) |
| "Melatonin is an endogenous hormone exerting multiple biological effects, mainly in regulating diurnal rhythms, also in inflammatory process and immune response." | 1.56 | Assessment of melatonergics in prevention of delirium in critically ill patients: A protocol for systematic review and meta-analysis. ( Du, B; Huang, H; Jiang, Z; Li, W; Ren, C; Wang, Y; Xi, X; Yao, Y; Zhang, L; Zhu, Y, 2020) |
| "Improvements in encephalopathy and medical stabilization did not rapidly normalize rhythms." | 1.56 | Factors Disrupting Melatonin Secretion Rhythms During Critical Illness. ( Abbott, SM; Eed, J; Gendy, M; Liotta, EM; Lizza, BD; Maas, MB; Naidech, AM; Reid, KJ; Zee, PC, 2020) |
| "Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal." | 1.43 | Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol. ( Burry, LD; Cheung, A; Chimunda, T; Choong, K; Duffett, M; Foster, J; Guenette, M; Menon, K; Rose, L; Thabane, L, 2016) |
| "Delirium has been associated with morbidity and mortality including more ventilator days, longer ICU stay, increased long-term mortality and cognitive impairment." | 1.43 | Pharmacological interventions for delirium in intensive care patients: a protocol for an overview of reviews. ( Barbateskovic, M; Jakobsen, JC; Larsen, LK; Oxenbøll-Collet, M; Perner, A; Wetterslev, J, 2016) |
| " Despite the critical illness, the oral bioavailability was satisfactory: serum levels after oral administration showed basically unchanged intestinal absorption, while disappearance rate was slower than reported elsewhere in healthy volunteers." | 1.36 | Pharmacokinetics of orally administered melatonin in critically ill patients. ( DeMartini, G; Dozio, E; Esposti, R; Figini, MA; Fraschini, F; Iapichino, G; Magni, P; Mistraletti, G; Reiter, RJ; Rezzani, R; Ruscica, M; Sabbatini, G; Taverna, M; Umbrello, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (10.87) | 29.6817 |
| 2010's | 25 (54.35) | 24.3611 |
| 2020's | 16 (34.78) | 2.80 |
| Authors | Studies |
|---|---|
| Kanova, M | 1 |
| Kohout, P | 1 |
| Wibrow, B | 1 |
| Martinez, FE | 1 |
| Myers, E | 1 |
| Chapman, A | 1 |
| Litton, E | 1 |
| Ho, KM | 1 |
| Regli, A | 1 |
| Hawkins, D | 1 |
| Ford, A | 1 |
| van Haren, FMP | 1 |
| Wyer, S | 1 |
| McCaffrey, J | 1 |
| Rashid, A | 1 |
| Kelty, E | 1 |
| Murray, K | 1 |
| Anstey, M | 1 |
| Peña-Mercado, E | 1 |
| Garcia-Lorenzana, M | 1 |
| Huerta-Yepez, S | 1 |
| Cruz-Ledesma, A | 1 |
| Beltran-Vargas, NE | 1 |
| Galley, HF | 1 |
| Allen, L | 1 |
| Colin, PJ | 1 |
| Galt, SP | 1 |
| Webster, NR | 1 |
| Yan, W | 1 |
| Li, C | 1 |
| Song, X | 1 |
| Zhou, W | 1 |
| Chen, Z | 1 |
| Melone, MA | 1 |
| Becker, TC | 1 |
| Wendt, LH | 1 |
| Ten Eyck, P | 1 |
| Patel, SB | 1 |
| Poston, J | 2 |
| Pohlman, AS | 2 |
| Pohlman, M | 2 |
| Miller, A | 2 |
| Nedeltcheva, A | 2 |
| Hall, JB | 2 |
| Van Cauter, E | 2 |
| Zabner, J | 1 |
| Gehlbach, BK | 2 |
| Supinski, GS | 1 |
| Schroder, EA | 1 |
| Callahan, LA | 1 |
| Diaz, E | 1 |
| Diaz, I | 1 |
| Del Busto, C | 1 |
| Escudero, D | 1 |
| Pérez, S | 1 |
| Zhu, Y | 1 |
| Jiang, Z | 1 |
| Huang, H | 2 |
| Wang, Y | 1 |
| Zhang, L | 1 |
| Ren, C | 1 |
| Yao, Y | 1 |
| Li, W | 1 |
| Du, B | 1 |
| Xi, X | 2 |
| Maas, MB | 2 |
| Lizza, BD | 2 |
| Kim, M | 1 |
| Abbott, SM | 2 |
| Gendy, M | 2 |
| Reid, KJ | 2 |
| Zee, PC | 2 |
| Liotta, EM | 1 |
| Eed, J | 1 |
| Naidech, AM | 1 |
| Soltani, F | 1 |
| Salari, A | 1 |
| Javaherforooshzadeh, F | 1 |
| Nassajjian, N | 1 |
| Kalantari, F | 1 |
| Foster, JR | 1 |
| Tijssen, JA | 1 |
| Miller, MR | 1 |
| Seabrook, JA | 1 |
| Fraser, DD | 1 |
| Schieveld, JNM | 1 |
| Strik, JJMH | 1 |
| Romero, N | 1 |
| Dube, KM | 1 |
| Lupi, KE | 1 |
| DeGrado, JR | 1 |
| Burry, L | 1 |
| Scales, D | 1 |
| Williamson, D | 1 |
| Foster, J | 2 |
| Mehta, S | 1 |
| Guenette, M | 2 |
| Fan, E | 1 |
| Detsky, M | 1 |
| Azad, A | 1 |
| Bernard, F | 1 |
| Rose, L | 2 |
| Mistraletti, G | 6 |
| Paroni, R | 2 |
| Umbrello, M | 6 |
| D'Amato, L | 1 |
| Sabbatini, G | 3 |
| Taverna, M | 4 |
| Formenti, P | 4 |
| Finati, E | 2 |
| Favero, G | 1 |
| Bonomini, F | 1 |
| Rezzani, R | 2 |
| Reiter, RJ | 5 |
| Iapichino, G | 6 |
| Wesselink, E | 1 |
| Koekkoek, WAC | 1 |
| Grefte, S | 1 |
| Witkamp, RF | 1 |
| van Zanten, ARH | 1 |
| Salini, S | 2 |
| Cadringher, P | 2 |
| Chiumello, D | 2 |
| Villa, C | 1 |
| Russo, R | 1 |
| Francesconi, S | 1 |
| Valdambrini, F | 1 |
| Bellani, G | 1 |
| Palo, A | 1 |
| Riccardi, F | 1 |
| Ferretti, E | 1 |
| Festa, M | 1 |
| Gado, AM | 1 |
| Pinna, C | 1 |
| Barbiero, A | 1 |
| Ferrari, PA | 1 |
| Baumgartner, L | 1 |
| Lam, K | 1 |
| Lai, J | 1 |
| Barnett, M | 1 |
| Thompson, A | 1 |
| Gross, K | 1 |
| Morris, A | 1 |
| Moro Salihovic, B | 1 |
| Coppola, S | 1 |
| Froio, S | 1 |
| Gasco, P | 1 |
| Savoca, A | 1 |
| Manca, D | 1 |
| Mantovani, ES | 2 |
| Cerri, B | 2 |
| Corbella, D | 1 |
| Anania, S | 1 |
| Andrighi, E | 1 |
| Barello, S | 1 |
| Di Carlo, A | 1 |
| Martinetti, F | 1 |
| Spanu, P | 2 |
| Jiang, L | 1 |
| Shen, L | 1 |
| Zhang, G | 1 |
| Zhu, B | 1 |
| Cheng, J | 1 |
| Miori, S | 1 |
| D'Agostino, A | 1 |
| Morabito, A | 1 |
| Fraschini, F | 2 |
| Mo, Y | 1 |
| Scheer, CE | 1 |
| Abdallah, GT | 1 |
| Billings, ME | 1 |
| Watson, NF | 1 |
| Madrid-Navarro, CJ | 1 |
| Sanchez-Galvez, R | 1 |
| Martinez-Nicolas, A | 1 |
| Marina, R | 1 |
| Garcia, JA | 1 |
| Madrid, JA | 1 |
| Rol, MA | 1 |
| Bellapart, J | 2 |
| Roberts, JA | 1 |
| Appadurai, V | 1 |
| Wallis, SC | 1 |
| Nuñez-Nuñez, M | 1 |
| Boots, RJ | 1 |
| Morandi, A | 1 |
| Brummel, NE | 1 |
| Pandharipande, P | 1 |
| Burry, LD | 1 |
| Thabane, L | 1 |
| Choong, K | 1 |
| Menon, K | 1 |
| Duffett, M | 1 |
| Cheung, A | 1 |
| Chimunda, T | 1 |
| Barbateskovic, M | 1 |
| Larsen, LK | 1 |
| Oxenbøll-Collet, M | 1 |
| Jakobsen, JC | 1 |
| Perner, A | 1 |
| Wetterslev, J | 1 |
| Korompeli, A | 1 |
| Muurlink, O | 1 |
| Kavrochorianou, N | 1 |
| Katsoulas, T | 1 |
| Fildissis, G | 1 |
| Baltopoulos, G | 1 |
| Figini, MA | 1 |
| Magni, P | 1 |
| Ruscica, M | 1 |
| Dozio, E | 1 |
| Esposti, R | 1 |
| DeMartini, G | 1 |
| Castro, R | 1 |
| Angus, DC | 1 |
| Rosengart, MR | 1 |
| Verceles, AC | 1 |
| Silhan, L | 1 |
| Terrin, M | 1 |
| Netzer, G | 1 |
| Shanholtz, C | 1 |
| Scharf, SM | 1 |
| Boyko, Y | 1 |
| Ording, H | 1 |
| Jennum, P | 1 |
| Boots, R | 1 |
| Chapotot, F | 1 |
| Leproult, R | 1 |
| Whitmore, H | 1 |
| Jacobsen, JH | 1 |
| Marseglia, L | 1 |
| Aversa, S | 1 |
| Barberi, I | 1 |
| Salpietro, CD | 1 |
| Cusumano, E | 1 |
| Speciale, A | 1 |
| Saija, A | 1 |
| Romeo, C | 1 |
| Trimarchi, G | 1 |
| Gitto, E | 1 |
| Yoshitaka, S | 1 |
| Egi, M | 1 |
| Morimatsu, H | 1 |
| Kanazawa, T | 1 |
| Toda, Y | 1 |
| Morita, K | 1 |
| Olofsson, K | 1 |
| Alling, C | 1 |
| Lundberg, D | 1 |
| Malmros, C | 1 |
| Bourne, RS | 2 |
| Mills, GH | 2 |
| Paul, T | 1 |
| Lemmer, B | 1 |
| Perras, B | 1 |
| Meier, M | 1 |
| Dodt, C | 1 |
| Minelli, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DELIRE-ICU: A Randomised Controlled Feasibility Trial of Melatonin vs Placebo in the Treatment of Delirium in the Intensive Care Unit[NCT05713877] | Phase 2 | 30 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | ||
| Feasibility of Melatonin for Prevention of Delirium in Critically Ill Patients: a Multi-centre, Randomized, Placebo-controlled Study.[NCT02615340] | Phase 2 | 69 participants (Anticipated) | Interventional | 2017-10-12 | Recruiting | ||
| Multicentric, Single Blind, Randomized Controlled Trial on Enteral Sedation Versus Intravenous Sedation in Critically Ill High-risk ICU Patients[NCT01360346] | Phase 3 | 300 participants (Anticipated) | Interventional | 2012-01-31 | Recruiting | ||
| Exogenous Melatonin in Intensive Care Unit Chronodisruption: Randomized Controled Trial[NCT03708341] | Phase 3 | 98 participants (Anticipated) | Interventional | 2018-11-15 | Recruiting | ||
| Impact of Low-dose Dexmedetomidine on Outcomes of Elderly Admitted to ICU After Noncardiac Surgery: a Randomized Controlled Trial[NCT04204798] | 1,410 participants (Anticipated) | Interventional | 2020-08-28 | Recruiting | |||
| Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study[NCT05307003] | 60 participants (Anticipated) | Observational | 2023-04-01 | Recruiting | |||
| Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)[NCT05085808] | Phase 4 | 30 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT03624595] | 502 participants (Anticipated) | Interventional | 2019-04-16 | Active, not recruiting | |||
| Melatonin Use in the Intensive Care Elderly Population[NCT03013790] | Phase 4 | 600 participants (Anticipated) | Interventional | 2016-12-31 | Recruiting | ||
| The Impact of Ramelteon on Sleep and Delirium in Patients Who Undergo Pulmonary Thromboendarterectomy (PTE) Surgery[NCT02691013] | 120 participants (Actual) | Interventional | 2016-02-29 | Active, not recruiting | |||
| Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Restore Resilience in Critically Ill Children[NCT04695392] | 56 participants (Actual) | Interventional | 2017-09-05 | Completed | |||
| Impact of Low-Dose Dexmedetomidine on Sleep Quality in Mechanical Ventilation Patients After Surgery in Intensive Care Unit: a Pilot Randomized, Double-Blind, Placebo-Controlled Trial[NCT03335527] | Phase 4 | 80 participants (Actual) | Interventional | 2017-11-17 | Completed | ||
| Association of Plasma Melatonin Levels With Delirium After Sevoflurane Anesthesia[NCT01570881] | 33 participants (Actual) | Observational | 2010-04-30 | Completed | |||
| The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172] | Phase 2 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| The Effect of Two Different General Anesthesia Regimes on Postoperative Sleep Quality[NCT02061514] | 80 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measured twice daily during the ICU stay using the Confusions Assessment Method instrument. (NCT02691013)
Timeframe: Twice daily for up to 10 days
| Intervention | hours (Median) |
|---|---|
| Placebo | 16 |
| Ramelteon | 24 |
(NCT02691013)
Timeframe: Duration of hospital admission
| Intervention | days (Median) |
|---|---|
| Placebo | 12 |
| Ramelteon | 12 |
(NCT02691013)
Timeframe: Duration of hospital admission
| Intervention | days (Median) |
|---|---|
| Placebo | 4 |
| Ramelteon | 4 |
Measured twice daily over the course of the ICU stay using the Confusion Assessment Method instrument (NCT02691013)
Timeframe: Twice daily for up to 10 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 22 |
| Ramelteon | 19 |
13 reviews available for melatonin and Critical Illness
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.
Topics: Adult; Critical Care; Critical Illness; Humans; Intensive Care Units; Length of Stay; Melatonin | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Mitochondria and Critical Illness.
Topics: Acute Lung Injury; Alarmins; Antioxidants; Cesium; Critical Illness; DNA, Mitochondrial; Humans; Mel | 2020 |
Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence.
Topics: Adenosine Triphosphate; Animals; Convalescence; Critical Illness; Electron Transport Chain Complex P | 2019 |
Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients.
Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Indenes; Inte | 2016 |
Circadian dysrhythmias in the intensive care unit.
Topics: Central Nervous System Depressants; Chronobiology Disorders; Critical Illness; Humans; Intensive Car | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Circadian disruption of ICU patients: A review of pathways, expression, and interventions.
Topics: Chronobiology Disorders; Circadian Rhythm; Clinical Alarms; Critical Care; Critical Illness; Humans; | 2017 |
The effect of light on critical illness.
Topics: Circadian Rhythm; Critical Illness; Humans; Lighting; Melatonin; Sunlight | 2011 |
Sleep disturbances in critically ill patients in ICU: how much do we know?
Topics: Adult; Aged; Critical Care; Critical Illness; Drug-Related Side Effects and Adverse Reactions; Femal | 2012 |
Potential use of melatonin in sleep and delirium in the critically ill.
Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car | 2012 |
Potential use of melatonin in sleep and delirium in the critically ill.
Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car | 2012 |
Potential use of melatonin in sleep and delirium in the critically ill.
Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car | 2012 |
Potential use of melatonin in sleep and delirium in the critically ill.
Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Intensive Car | 2012 |
Melatonin: possible implications for the postoperative and critically ill patient.
Topics: Critical Illness; Humans; Intensive Care Units; Melatonin; Postoperative Care; United Kingdom | 2006 |
Melatonin: possible implications for the postoperative and critically ill patient.
Topics: Critical Illness; Humans; Intensive Care Units; Melatonin; Postoperative Care; United Kingdom | 2006 |
Melatonin: possible implications for the postoperative and critically ill patient.
Topics: Critical Illness; Humans; Intensive Care Units; Melatonin; Postoperative Care; United Kingdom | 2006 |
Melatonin: possible implications for the postoperative and critically ill patient.
Topics: Critical Illness; Humans; Intensive Care Units; Melatonin; Postoperative Care; United Kingdom | 2006 |
15 trials available for melatonin and Critical Illness
| Article | Year |
|---|---|
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial.
Topics: Australia; Critical Care; Critical Illness; Delirium; Double-Blind Method; Humans; Intensive Care Un | 2022 |
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis.
Topics: Antioxidants; Critical Illness; Humans; Melatonin; Sepsis | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic intracranial hemorrhage patients: a randomized controlled trial.
Topics: Critical Illness; Humans; Hypnotics and Sedatives; Intensive Care Units; Intracranial Hemorrhage, Tr | 2022 |
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum | 2017 |
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum | 2017 |
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum | 2017 |
Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Critical Illness; Delirium; Female; Hum | 2017 |
Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Circadian Rhythm; Critical Illness; Cytochromes c; Dou | 2017 |
Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial.
Topics: Aged; Anesthesia; Antipruritics; Central Nervous System Depressants; Critical Illness; Deep Sedation | 2019 |
Different routes and formulations of melatonin in critically ill patients. A pharmacokinetic randomized study.
Topics: Aged; Aged, 80 and over; Colloids; Critical Illness; Female; Humans; Intensive Care Units; Male; Mel | 2019 |
Enteral vs. intravenous ICU sedation management: study protocol for a randomized controlled trial.
Topics: Administration, Oral; Anesthetics, Intravenous; Clinical Protocols; Computer-Assisted Instruction; C | 2013 |
Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial.
Topics: Administration, Oral; Biomarkers; China; Circadian Rhythm; Clinical Protocols; Critical Illness; Dou | 2014 |
Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial.
Topics: Aged; Conscious Sedation; Critical Care; Critical Illness; Double-Blind Method; Female; Humans; Hydr | 2015 |
Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients.
Topics: Administration, Oral; Adult; Aged; Central Nervous System Depressants; Critical Illness; Humans; Mel | 2016 |
High endogenous melatonin levels in critically ill children: a pilot study.
Topics: Child, Preschool; Circadian Rhythm; Critical Illness; Female; Humans; Light; Male; Melatonin; Pilot | 2013 |
Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Critical Care; Critical Illness; Drug Therapy, Combinatio | 2004 |
Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial.
Topics: Administration, Oral; Aged; Area Under Curve; Central Nervous System Depressants; Critical Illness; | 2008 |
19 other studies available for melatonin and Critical Illness
| Article | Year |
|---|---|
Effect of melatonin on electrical impedance and biomarkers of damage in a gastric ischemia/reperfusion model.
Topics: Animals; Biomarkers; Critical Illness; Electric Impedance; Gastric Mucosa; Ischemia; Male; Melatonin | 2022 |
Disruption of the circadian rhythm of melatonin: A biomarker of critical illness severity.
Topics: Biomarkers; Circadian Rhythm; Critical Illness; Humans; Melatonin; Retrospective Studies | 2023 |
Clock Genes Disruption in the Intensive Care Unit.
Topics: Circadian Rhythm; Critical Illness; Humans; Intensive Care Units; Melatonin; RNA, Messenger | 2020 |
Assessment of melatonergics in prevention of delirium in critically ill patients: A protocol for systematic review and meta-analysis.
Topics: Critical Illness; Delirium; Humans; Intensive Care Units; Length of Stay; Melatonin; Meta-Analysis a | 2020 |
Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness.
Topics: Academic Medical Centers; Actigraphy; Circadian Rhythm; Critical Care; Critical Illness; Cross-Secti | 2020 |
Factors Disrupting Melatonin Secretion Rhythms During Critical Illness.
Topics: Academic Medical Centers; Adult; Aged; Aged, 80 and over; Arousal; Brain Diseases; Cerebral Hemorrha | 2020 |
Total Daily Production and Periodicity of Melatonin Metabolite in Critically Ill Children.
Topics: Child; Circadian Rhythm; Critical Illness; Humans; Infant; Melatonin; Prospective Studies; Sepsis | 2020 |
Melatonin and Sleep Dysregulation at the PICU.
Topics: Child; Critical Illness; Humans; Intensive Care Units, Pediatric; Melatonin; Sleep | 2020 |
Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon.
Topics: Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Indenes; Intensive Care Units; Melatoni | 2021 |
Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium.
Topics: Adult; Aged; Cohort Studies; Critical Illness; Delirium; Female; Humans; Intensive Care Units; Lengt | 2019 |
Melatonin and the future of critically ill patients' outcomes.
Topics: Critical Illness; Humans; Intensive Care Units; Melatonin | 2015 |
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol.
Topics: Critical Care; Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Melatonin; Research Desi | 2016 |
Pharmacological interventions for delirium in intensive care patients: a protocol for an overview of reviews.
Topics: Critical Care; Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Melatonin; Meta-Analysis | 2016 |
Pharmacokinetics of orally administered melatonin in critically ill patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Biological Availability; Circadian Rhythm; Critical I | 2010 |
Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Circadian Rhythm; Critical Illn | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.
Topics: Administration, Intravenous; Aged; Circadian Rhythm; Critical Illness; Electrocardiography; Female; | 2012 |
Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium.
Topics: Aged; APACHE; Chi-Square Distribution; Comorbidity; Critical Illness; Delirium; Female; Humans; Inte | 2013 |
Disturbance of circadian rhythms in analgosedated intensive care unit patients with and without craniocerebral injury.
Topics: Adult; Analgesics; Blood Pressure; Body Temperature; Case-Control Studies; Circadian Rhythm; Cranioc | 2007 |
Light and darkness fail to regulate melatonin release in critically ill humans.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Darkness; Female; Germany; Humans; Intensive Care | 2007 |