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melatonin and Colorectal Cancer

melatonin has been researched along with Colorectal Cancer in 45 studies

Research Excerpts

ExcerptRelevanceReference
" In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone."9.07A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994)
"In the current study, the underlying anti-metastatic mechanism of melatonin contained in some edible plants was explored in association with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal cancer cells."8.02Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers. ( Im, E; Kim, DH; Kim, SH; Koo, J; Lee, HJ; Oh, BS; Pak, JN; Park, JE; Park, WY; Park, Y; Shim, BS; Sim, DY, 2021)
"Preclinical evidence suggests that melatonin may affect cellular pathways involved in colorectal cancer (CRC)."8.02Use of Melatonin Is Associated With Lower Risk of Colorectal Cancer in Older Adults. ( Ji, J; Sundquist, J; Sundquist, K; Zhang, N, 2021)
"5-Fluorouracil (5-FU) has been established as the first-line chemotherapy for advanced colorectal cancer (CRC); however, acquired chemoresistance is often the cause of poor therapeutic response."7.91Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells. ( Goel, A; Sakatani, A; Sonohara, F, 2019)
"Melatonin, an endogenously secreted indoleamine hormone that is produced in the pineal gland, is known to possess antitumor effect via various mechanisms including induction of apoptosis and pro-oxidant effects in various cancer cells, including colorectal cancer (CRC)."7.88Melatonin Promotes Apoptosis of Colorectal Cancer Cells ( Kim, S; Lee, JH; Lee, SH; Yun, CW, 2018)
"Melatonin induces apoptosis in many different cancer cell lines, including colorectal cancer."7.81Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation. ( He, W; Li, WM; Lu, QN; Wei, JY; Zhou, LL, 2015)
"Circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been studied in stomach cancer (n = 89) and colorectal cancer (n = 86) patients."7.78[Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients]. ( Anisimov, VN; Arutiunian, AV; Ermachenkov, MN; Guliaev, AV; Miliutina, IuP, 2012)
"Since there is no effective second line chemotherapy in colorectal cancer resistant to fluorouracil, this study was carried out to evaluate the therapeutic activity of the pineal hormone melatonin, which has appeared to have antineoplastic activity in some experimental conditions, in patients with metastatic colorectal carcinoma who did not respond to fluorouracil."7.68A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates. ( Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G, 1990)
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally."6.66The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020)
"Colorectal cancer is one of the most common cancers among the elderly, which is also seen in the forms of hereditary syndromes occurring in younger individuals."6.66Melatonin: An important anticancer agent in colorectal cancer. ( Ghazizadeh, S; Gholamzadeh, S; Majidinia, M; Mihanfar, A; Mirza-Aghazadeh-Attari, M; Mohammadzadeh, A; Mostavafi, S; Sadighparvar, S; Yousefi, B, 2020)
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes."5.62Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021)
"Melatonin has antitumor activity via several mechanisms including its anti-proliferative and pro-apoptotic effects."5.48Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro. ( Bejarano, I; Espino, J; Pariente, JA; Pariente, R; Rodríguez, AB, 2018)
"In Asia, the incidence of colorectal cancer has been increasing gradually due to a more Westernized lifestyle."5.40Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. ( Chang, KT; Hong, Y; Lee, S; Lee, Y; Park, K; Won, J, 2014)
" In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone."5.07A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; 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Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"In the current study, the underlying anti-metastatic mechanism of melatonin contained in some edible plants was explored in association with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal cancer cells."4.02Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers. ( Im, E; Kim, DH; Kim, SH; Koo, J; Lee, HJ; Oh, BS; Pak, JN; Park, JE; Park, WY; Park, Y; Shim, BS; Sim, DY, 2021)
"Preclinical evidence suggests that melatonin may affect cellular pathways involved in colorectal cancer (CRC)."4.02Use of Melatonin Is Associated With Lower Risk of Colorectal Cancer in Older Adults. ( Ji, J; Sundquist, J; Sundquist, K; Zhang, N, 2021)
"5-Fluorouracil (5-FU) has been established as the first-line chemotherapy for advanced colorectal cancer (CRC); however, acquired chemoresistance is often the cause of poor therapeutic response."3.91Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells. ( Goel, A; Sakatani, A; Sonohara, F, 2019)
"Melatonin, an endogenously secreted indoleamine hormone that is produced in the pineal gland, is known to possess antitumor effect via various mechanisms including induction of apoptosis and pro-oxidant effects in various cancer cells, including colorectal cancer (CRC)."3.88Melatonin Promotes Apoptosis of Colorectal Cancer Cells ( Kim, S; Lee, JH; Lee, SH; Yun, CW, 2018)
"Melatonin induces apoptosis in many different cancer cell lines, including colorectal cancer."3.81Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation. ( He, W; Li, WM; Lu, QN; Wei, JY; Zhou, LL, 2015)
" In this study, we evaluated the effect of melatonin on the genotoxic activity of irinotecan in healthy human lymphocytes and a lung cancer cell line (A549) and a colorectal adenocarcinoma cell line (HT29) in vitro."3.79The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells. ( Kontek, R; Nowicka, H, 2013)
"Circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been studied in stomach cancer (n = 89) and colorectal cancer (n = 86) patients."3.78[Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients]. ( Anisimov, VN; Arutiunian, AV; Ermachenkov, MN; Guliaev, AV; Miliutina, IuP, 2012)
"Since there is no effective second line chemotherapy in colorectal cancer resistant to fluorouracil, this study was carried out to evaluate the therapeutic activity of the pineal hormone melatonin, which has appeared to have antineoplastic activity in some experimental conditions, in patients with metastatic colorectal carcinoma who did not respond to fluorouracil."3.68A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates. ( Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G, 1990)
"Melatonin was given orally at 20 mg/day in the evening for at least 2 months."2.70Anti-angiogenic activity of melatonin in advanced cancer patients. ( Bucovec, R; Conti, A; Lissoni, P; Maestroni, GJ; Malugani, F; Rovelli, F, 2001)
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally."2.66The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020)
"Colorectal cancer is one of the most common cancers among the elderly, which is also seen in the forms of hereditary syndromes occurring in younger individuals."2.66Melatonin: An important anticancer agent in colorectal cancer. ( Ghazizadeh, S; Gholamzadeh, S; Majidinia, M; Mihanfar, A; Mirza-Aghazadeh-Attari, M; Mohammadzadeh, A; Mostavafi, S; Sadighparvar, S; Yousefi, B, 2020)
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes."1.62Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021)
"Melatonin has antitumor activity via several mechanisms including its anti-proliferative and pro-apoptotic effects."1.48Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro. ( Bejarano, I; Espino, J; Pariente, JA; Pariente, R; Rodríguez, AB, 2018)
"p53 loss increases the pool of CSCs in colorectal cancer (CRC)."1.46AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. ( Carazo-Gallego, Á; Casado, J; González-Puga, C; Iñigo-Chaves, A; Jiménez-Ruiz, SM; León, J; Núñez, MI; Ríos-Arrabal, S; Ruíz-Extremera, Á; Salmerón, J, 2017)
"In Asia, the incidence of colorectal cancer has been increasing gradually due to a more Westernized lifestyle."1.40Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. ( Chang, KT; Hong, Y; Lee, S; Lee, Y; Park, K; Won, J, 2014)
"We documented 602 incident cases of colorectal cancer among 78 586 women who were followed up from 1988 through 1998."1.32Night-shift work and risk of colorectal cancer in the nurses' health study. ( Colditz, GA; Fuchs, CS; Hunter, DJ; Kawachi, I; Laden, F; Schernhammer, ES; Speizer, FE; Willett, WC, 2003)
"Since colorectal cancer should not have any daylight-related hormone dependent risk determinants, a control cohort of 12,950 women with a diagnosis of colorectal cancer in the same calendar period was studied in a similar way."1.29Does the month of diagnosis affect survival of cancer patients? ( Joensuu, H; Pukkala, E; Sankila, R; Toikkanen, S, 1993)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (8.89)18.2507
2000's9 (20.00)29.6817
2010's16 (35.56)24.3611
2020's16 (35.56)2.80

Authors

AuthorsStudies
Pan, S1
Guo, Y1
Hong, F1
Xu, P1
Zhai, Y1
Li, YC1
Chen, CH1
Chang, CL1
Chiang, JY1
Chu, CH1
Chen, HH1
Yip, HK1
Zhao, Y3
Wang, C1
Goel, A2
Erdogan, CS1
Al Hassadi, Y1
Aru, B1
Yılmaz, B1
Gemici, B1
Wu, H1
Liu, J3
Yin, Y1
Zhang, D1
Xia, P1
Zhu, G1
Iravani, S1
Eslami, P1
Dooghaie Moghadam, A1
Moazzami, B1
Mehrvar, A1
Hashemi, MR1
Mansour-Ghanaei, F1
Mansour-Ghanaei, A1
Majidzadeh-A, K1
Gil-Martín, E2
López-Muñoz, F1
Reiter, RJ3
Romero, A2
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J1
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J7
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Li, Y6
Xu, T1
Li, C2
Ji, F1
Ming, F1
Cheng, J1
Wang, Y4
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C1
Wu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C3
Lin, Y1
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y4
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Yang, K2
Zhai, C1
Yang, M1
Lao, X1
Sun, J1
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
Mathews, D1
Agnese, W1
Apple, S1
Meloncelli, S1
Divizia, M1
Germani, G1
Adefegha, SA1
Bottari, NB1
Leal, DB1
de Andrade, CM1
Schetinger, MR1
Martínez-Velasco, A1
Perez-Ortiz, AC1
Antonio-Aguirre, B1
Martínez-Villaseñor, L1
Lira-Romero, E1
Palacio-Pastrana, C1
Zenteno, JC1
Ramirez, I1
Zepeda-Palacio, C1
Mendoza-Velásquez, C1
Camacho-Ordóñez, A1
Ortiz Bibriesca, DM1
Estrada-Mena, FJ1
Martin, BL1
Thompson, LC1
Kim, YH2
Snow, SJ1
Schladweiler, MC1
Phillips, P1
Harmon, M1
King, C1
Richards, J1
George, I1
Haykal-Coates, N1
Gilmour, MI1
Kodavanti, UP1
Hazari, MS1
Farraj, AK1
Shen, Z1
Zou, Y1
Gao, K1
Lazar, S1
Wurtzel, JGT1
Ma, P1
Goldfinger, LE1
Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
Chen, J2
Xun, J1
Hu, Z1
Huang, Q2
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Guo, X1
Cao, Y1
Jia, X1
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
Wang, YF1
Cong, WL1
Liu, LP1
Li, XX1
Zhou, CL1
Chen, WM1
Wei, KL1
Tung, SY1
Shen, CH1
Chang, TS1
Yen, CW1
Hsieh, YY1
Chiu, WN1
Hu, JH1
Lu, SN1
Hung, CH1
Alakavuklar, MA1
Fuqua, C1
Luo, KL1
Underwood, RS1
Greenwald, I1
Elashiry, MM1
Elashiry, M1
Zeitoun, R1
Elsayed, R1
Tian, F1
Saber, SE1
Elashry, SH1
Tay, FR1
Cutler, CW1
O'Dowd, A1
Maciel, M1
Poole, ST1
Jobling, MG1
Rollenhagen, JE1
Woods, CM1
Sincock, SA1
McVeigh, AL1
Gregory, MJ1
Maves, RC1
Prouty, MG1
Holmes, RK1
Savarino, SJ1
Mor, MK1
Palevsky, PM1
Kaufman, JS1
Thiessen Philbrook, H1
Weisbord, SD1
Parikh, CR1
John, CM1
Phillips, NJ1
Jarvis, GA1
Zhu, Y1
Kilburn, S1
Kapoor, M1
Chaturvedi, S1
Shaw, KJ1
Chaturvedi, V1
Kong, X1
Zhang, T1
Xiao, H1
Feng, X1
Tu, H1
Feng, J1
Sabet, M1
Tarazi, Z1
Griffith, DC1
Nguyen, F1
Guan, P1
Guerrero, DT1
Kolla, V1
Naraparaju, K1
Perry, LM1
Soberman, D1
Pressly, BB1
Alferiev, IS1
Chorny, M1
Brodeur, GM1
Gao, X2
Cheng, YH1
Enten, GA1
DeSantis, AJ1
Gaponenko, V1
Majetschak, M1
Kim, DY1
Choi, MJ1
Ko, TK1
Lee, NH1
Kim, OH1
Cheon, HG1
Cai, H1
Yip, V1
Lee, MV1
Wong, S1
Saad, O1
Ma, S1
Ljumanovic, N1
Khojasteh, SC1
Kamath, AV1
Shen, BQ1
Cuypers, ML1
Chanteux, H1
Gillent, E1
Bonnaillie, P1
Saunders, K1
Beckers, C1
Delatour, C1
Dell'Aiera, S1
Ungell, AL1
Nicolaï, J1
Knapp, AK1
Chen, A1
Griffin-Nolan, RJ1
Baur, LE1
Carroll, CJW1
Gray, JE1
Hoffman, AM1
Li, X6
Post, AK1
Slette, IJ1
Collins, SL1
Luo, Y1
Smith, MD1
Temitayo, GI1
Olawande, B1
Emmanuel, YO1
Timothy, AT1
Kehinde, O1
Susan, LF1
Ezra, L1
Joseph, OO1
Lev, S1
Desmarini, D1
Liuwantara, D1
Sorrell, TC1
Hawthorne, WJ1
Djordjevic, JT1
Verso, MG1
Costantino, C1
Marrella, A1
Immordino, P1
Vitale, F1
Amodio, E1
Wang, YD1
Yao, WL1
Xin, ZM1
Han, TT1
Wang, ZG1
Chen, L1
Cai, C1
Zhang, Y4
Ba, D1
Wen, S1
Tian, Q1
Lv, W1
Cheng, G1
Li, N1
Yue, XY1
Chu, WJ1
Chen, Q1
Choi, ES1
Zhao, X3
Zhou, HD1
Sun, XF1
Sharma, S2
Chhoker, S1
Xie, C1
Ong, EWY1
Tan, ZK1
Evans, S1
Weinheimer, CJ1
Kovacs, A1
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Mann, DL1
Huang, Y1
Kong, L1
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Mendes, GC1
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Mou, LH1
Chen, JJ1
Li, ZY1
He, SG1
Reale, E1
Fustinoni, S1
Mercadante, R1
Polledri, E1
Hopf, NB1
Grant, PC1
Levy, K1
Lattimer, TA1
Depner, RM1
Kerr, CW1
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Merenda, MEZ1
Uemoto, AT1
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Barion, MRL1
Carciofi, AC1
de Paula Dorigam, JC1
Ribeiro, LB1
Vasconcellos, RS1
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Wang, Z2
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Li, XQ1
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Palaparthi, A1
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González, MA1
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Mathew, AP1
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Pan, K1
Li, Z2
Zhou, W2
Ghassemi Tabrizi, S1
Arbuznikov, AV1
Jiménez-Hoyos, CA1
Kaupp, M1
Lin, MH2
Bulman, DM1
Remucal, CK1
Chaplin, BP1
Laguerre, A1
George, LA1
Gall, ET1
Emerson, MS1
Wang, H3
Maginn, EJ1
Margulis, CJ1
Li, H2
Feng, W1
Kang, X2
Yan, S1
Chao, M1
Mo, S1
Sun, W1
Lu, Y1
Chen, C1
Stevens, DM1
Adiseshaiah, P1
Dasa, SSK1
Potter, TM1
Skoczen, SL1
Snapp, KS1
Cedrone, E1
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Rosen, EP1
Sykes, C1
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Estes, JD1
Kashuba, ADM1
Stern, ST1
Özütemiz, C1
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Rubin, NT1
Ozturk, K1
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Kraus, WE1
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Mehmood, T1
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Kim, DU1
Kim, J1
Yeter, HH1
Gonul, I1
Guz, G1
Helvaci, O1
Korucu, B1
Akcay, OF1
Derici, U1
Arinsoy, T1
Neffati, R1
Judeinstein, P1
Rault, J1
Xu, Y1
Chai, X1
Ren, T1
Yu, S1
Fu, Q2
Ye, J1
Ge, X1
Song, J1
Yang, H2
El-Baba, TJ1
Lutomski, CA1
Kantsadi, AL1
Malla, TR1
John, T1
Mikhailov, V1
Bolla, JR1
Schofield, CJ1
Zitzmann, N1
Vakonakis, I1
Robinson, CV1
Langham, MC1
Caporale, AS1
Wehrli, FW1
Parry, S1
Schwartz, N1
den Boer, RB1
Jones, KI1
Ash, S1
van Boxel, GI1
Gillies, RS1
O'Donnell, T1
Ruurda, JP1
Sgromo, B1
Silva, MA1
Maynard, ND1
Sivieri, EM1
Eichenwald, EC1
Rub, D1
Abbasi, S2
Krahnert, I1
Bolze, A1
Gibon, Y1
Fernie, AR1
Huang, L1
Wan, Y1
Dang, Z1
Yang, P1
Yang, Q1
Wu, S2
Lin, CC1
Hsu, CT1
Liu, W2
Huang, SC1
Kortz, U1
Mougharbel, AS1
Chen, TY1
Hu, CW1
Lee, JF1
Wang, CC1
Liao, YF1
Li, LJ1
Li, L1
Peng, S1
Stimming, U1
Hebbar Kannur, K1
Yaqub, TB1
Pupier, C1
Héau, C1
Cavaleiro, A1
Yamamoto, S1
Ono, A1
Matsui, J1
Hoshino, N1
Akutagawa, T1
Miyashita, T1
Mitsuishi, M1
Patel, SM1
Smith, TG1
Morton, M1
Stiers, KM1
Seravalli, J1
Mayclin, SJ1
Edwards, TE1
Tanner, JJ1
Becker, DF1
Butcher, TW1
Yang, JL1
Hartwig, JF1
Yu, MF1
Xia, ZZ1
Yao, JC1
Feng, Z1
Li, DH1
Liu, T1
Cheng, GJ1
He, DL1
Li, XH1
Huurman, R1
Schinkel, AFL1
de Jong, PL1
van Slegtenhorst, MA1
Hirsch, A1
Michels, M1
Kataja, A1
Tarvasmäki, T1
Lassus, J1
Sionis, A1
Mebazaa, A1
Pulkki, K1
Banaszewski, M1
Carubelli, V1
Hongisto, M1
Jankowska, E1
Jurkko, R1
Jäntti, T1
Kasztura, M1
Parissis, J1
Sabell, T1
Silva-Cardoso, J1
Spinar, J1
Tolppanen, H1
Harjola, VP1
Carsetti, A1
Damiani, E1
Casarotta, E1
Scorcella, C1
Domizi, R1
Gasparri, F1
Gabbanelli, V1
Pantanetti, S1
Carozza, R1
Adrario, E1
Donati, A1
Almada, E1
Pariani, A1
Rivabella Maknis, T1
Hidalgo, F1
Vena, R1
Favre, C1
Larocca, MC1
Lu, ZY1
Jiang, WD1
Wu, P1
Kuang, SY1
Tang, L1
Yang, J1
Zhou, XQ1
Feng, L1
Leal, M1
Zampini, IC1
Mercado, MI1
Moreno, MA1
Simirgiotis, MJ1
Bórquez, J1
Ponessa, G1
Isla, MI1
Saliu, IO1
Amoo, ZA1
Khan, MF1
Olaleye, MT1
Rema, V1
Akinmoladun, AC1
Khan, AU1
Rahman, AU1
Yuan, Q1
Ahmad, A1
Khan, ZUH1
Mahnashi, MH1
Alyami, BA1
Alqahtani, YS1
Ullah, S1
Wirman, AP1
Gao, M1
Deng, L1
Zhang, K1
Wang, M1
Xia, Z1
Gao, D1
Balkissou, AD1
Poka-Mayap, V1
Massongo, M1
Djenabou, A1
Endale-Mangamba, LM1
Olomo, EJ1
Boulleys-Nana, JR1
Diffo-Sonkoue, L1
Adidigue-Ndiome, R1
Alexandra, AJE1
Haman-Wabi, AB1
Adama, S1
Iddi-Faical, A1
Pefura-Yone, EW1
Zhao, Q1
Tong, W1
Ge, C1
Zhao, D1
Norbäck, D1
Li, B1
Zhao, Z1
Huang, C1
Zhang, X1
Qian, H1
Yang, X1
Sun, Y1
Sundell, J1
Deng, Q1
Kim, HJ1
Jeon, JW1
Hwang, SM1
Chu, KI1
Cha, YH1
Kwak, YD1
Choi, SD1
Aslam, M1
Kim, CG1
Zhou, J1
Yang, E1
Yang, W1
Ji, G1
Du, J1
Hao, H1
Jadid, MFS1
Aghaei, E1
Taheri, E1
Seyyedsani, N1
Chavoshi, R1
Khorrami, A1
Goleij, P1
Hajazimian, S1
Taefehshokr, S1
Isazadeh, A1
Shanehbandi, D1
Oh, BS1
Im, E1
Lee, HJ1
Sim, DY1
Park, JE1
Park, WY1
Park, Y1
Koo, J1
Pak, JN1
Kim, DH1
Shim, BS1
Kim, SH1
Kvietkauskas, M1
Zitkute, V1
Leber, B1
Strupas, K1
Stiegler, P1
Schemmer, P1
Zhang, N1
Sundquist, J1
Sundquist, K1
Ji, J1
Razi Soofiyani, S1
Ahangari, H1
Soleimanian, A1
Babaei, G1
Ghasemnejad, T1
Safavi, SE1
Eyvazi, S1
Tarhriz, V1
Chok, KC2
Koh, RY2
Ng, MG1
Ng, PY1
Chye, SM2
Zhou, R1
Park, SY1
Back, K1
Bae, WK1
Kim, KK1
Kim, H1
Casado, J2
Iñigo-Chaves, A1
Jiménez-Ruiz, SM1
Ríos-Arrabal, S1
Carazo-Gallego, Á1
González-Puga, C1
Núñez, MI1
Ruíz-Extremera, Á2
Salmerón, J2
León, J2
Pariente, R1
Bejarano, I1
Rodríguez, AB1
Pariente, JA1
Espino, J1
Bakalova, R1
Zhelev, Z1
Shibata, S1
Nikolova, B1
Aoki, I1
Higashi, T1
Yun, CW1
Kim, S1
Lee, JH1
Lee, SH1
Wang, Q1
Sun, Z1
Du, L1
Xu, C1
Yang, B1
He, N1
Ji, K1
Liu, Q1
Sakatani, A1
Sonohara, F1
Egea, J1
Shafabakhsh, R1
Davoodabadi, A1
Asemi, Z1
Ng, CH1
Ng, KY1
Mirza-Aghazadeh-Attari, M1
Mohammadzadeh, A1
Mostavafi, S1
Mihanfar, A1
Ghazizadeh, S1
Sadighparvar, S1
Gholamzadeh, S1
Majidinia, M1
Yousefi, B1
Hong, Y2
Won, J1
Lee, Y1
Lee, S1
Park, K1
Chang, KT1
Wei, JY1
Li, WM1
Zhou, LL1
Lu, QN1
He, W1
Bilski, B1
Carazo, A1
Sanjuán, L1
Maté, A1
Muñoz de Rueda, P1
de la Cueva, P1
Quiles, R1
Ruíz, S1
Kontek, R1
Nowicka, H1
Ermachenkov, MN1
Guliaev, AV1
Arutiunian, AV1
Miliutina, IuP1
Anisimov, VN2
Schernhammer, ES1
Laden, F1
Speizer, FE1
Willett, WC1
Hunter, DJ1
Kawachi, I1
Fuchs, CS1
Colditz, GA1
Muc-Wierzgon, M1
Nowakowska-Zajdel, E1
Zubelewicz, B1
Wierzgon, J1
Kokot, T1
Klakla, K1
Szkilnik, R1
Wiczkowski, A1
Lissoni, P4
Barni, S3
Tancini, G3
Ardizzoia, A2
Ricci, G1
Aldeghi, R1
Brivio, F2
Tisi, E1
Rovelli, F2
Rescaldani, R1
Sankila, R1
Joensuu, H1
Pukkala, E1
Toikkanen, S1
Zabezhinskiĭ, MA1
Popovich, IG1
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Kvetnoĭ, IM1
Kvetnaia, TV1
Popuchiev, VV1
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Mormont, MC1
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Kozlowski, A1
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Kudla, M1
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Strzelczyk, J1
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Perego, M1
Maestroni, G1
Crispino, S1
Archili, C1

Reviews

12 reviews available for melatonin and Colorectal Cancer

ArticleYear
Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota.
    Biochimica et biophysica acta. Molecular basis of disease, 2022, 01-01, Volume: 1868, Issue:1

    Topics: Apoptosis; Carcinogenesis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gastrointestinal

2022
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action.
    BioMed research international, 2019, Volume: 2019

    Topics: Apoptosis; Autophagy; Cell Proliferation; Circadian Rhythm; Colorectal Neoplasms; Gastrointestinal T

2019
The Role of Melatonin in Colorectal Cancer.
    Journal of gastrointestinal cancer, 2020, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Carcinogenesis; Colorectal Ne

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
The role of circadian genes in the pathogenesis of colorectal cancer.
    Gene, 2021, Dec-15, Volume: 804

    Topics: Brain; Circadian Clocks; Circadian Rhythm; Colorectal Neoplasms; Humans; Hypothalamus; Melatonin; Pe

2021
The emergence of melatonin in oncology: Focus on colorectal cancer.
    Medicinal research reviews, 2019, Volume: 39, Issue:6

    Topics: Animals; Colorectal Neoplasms; Disease Progression; Epigenesis, Genetic; Humans; Melatonin; Neoplast

2019
Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; Humans; Inflammation; Melatoni

2019
The potential therapeutic actions of melatonin in colorectal cancer.
    Hormone molecular biology and clinical investigation, 2019, May-29, Volume: 39, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Proliferation; Circadian Rhythm; Colorect

2019
Melatonin: An important anticancer agent in colorectal cancer.
    Journal of cellular physiology, 2020, Volume: 235, Issue:2

    Topics: Aging; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Prolife

2020
[Shift and night work--is it a cancer risk factor?].
    Medycyna pracy, 2005, Volume: 56, Issue:2

    Topics: Breast Neoplasms; Causality; Chronobiology Disorders; Circadian Rhythm; Colorectal Neoplasms; Female

2005
[Melatonin inhibits large bowel carcinogenesis induced by 1,2-dimethylhydrazine in rats: effects and possible mechanisms].
    Voprosy onkologii, 2000, Volume: 46, Issue:2

    Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Colorectal Neoplasms; DNA Repair; Free Radic

2000

Trials

4 trials available for melatonin and Colorectal Cancer

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma.
    British journal of cancer, 1994, Volume: 69, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Colorec

1994
Anti-angiogenic activity of melatonin in advanced cancer patients.
    Neuro endocrinology letters, 2001, Volume: 22, Issue:1

    Topics: Adult; Aged; Bone Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; C

2001

Other Studies

31 other studies available for melatonin and Colorectal Cancer

ArticleYear
Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms.
    International journal of biological sciences, 2021, Volume: 17, Issue:14

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Comb

2021
A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer.
    Carcinogenesis, 2022, 04-25, Volume: 43, Issue:3

    Topics: Andrographis; Animals; Autophagy; Biological Products; Colorectal Neoplasms; Humans; Melatonin

2022
Combinatorial effects of melatonin and paclitaxel differ depending on the treatment scheme in colorectal cancer in vitro.
    Life sciences, 2022, Nov-01, Volume: 308

    Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Humans; Melatonin; Paclitaxel; TOR Serine-Threoni

2022
Understanding the oncostatic actions displayed by melatonin in colorectal cancer therapy.
    Future medicinal chemistry, 2020, Volume: 12, Issue:13

    Topics: Antineoplastic Agents; Cell Proliferation; Colorectal Neoplasms; Humans; Melatonin

2020
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster.
    Molecular medicine reports, 2021, Volume: 23, Issue:3

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Colorectal Neoplasms; HCT116 Cells; HT29 Cell

2021
Melatonin increases the anticancer potential of doxorubicin in Caco-2 colorectal cancer cells.
    Environmental toxicology, 2021, Volume: 36, Issue:6

    Topics: Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Doxorubicin; Hu

2021
Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:8

    Topics: Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expre

2021
Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis.
    Nutrients, 2021, Jun-13, Volume: 13, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Glycine; Leukocyte C

2021
Use of Melatonin Is Associated With Lower Risk of Colorectal Cancer in Older Adults.
    Clinical and translational gastroenterology, 2021, 08-03, Volume: 12, Issue:8

    Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Incidence; Male; Melatonin; Middl

2021
Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells.
    Molecules (Basel, Switzerland), 2021, Aug-20, Volume: 26, Issue:16

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Caco-2 Cells; Cell Line,

2021
2-Hydroxymelatonin, a Predominant Hydroxylated Melatonin Metabolite in Plants, Shows Antitumor Activity against Human Colorectal Cancer Cells.
    Molecules (Basel, Switzerland), 2017, Mar-14, Volume: 22, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cell Survival

2017
AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
    International journal of molecular sciences, 2017, Jun-11, Volume: 18, Issue:6

    Topics: Aged; Aged, 80 and over; Arylalkylamine N-Acetyltransferase; Colorectal Neoplasms; Female; Gene Expr

2017
Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro.
    Molecular and cellular biochemistry, 2018, Volume: 440, Issue:1-2

    Topics: Adenocarcinoma; Cell Line, Tumor; Colorectal Neoplasms; Fluorouracil; Humans; Melatonin

2018
Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic"
    Anticancer research, 2017, Volume: 37, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzylidene Compounds; Camptothecin; Cell L

2017
Melatonin Promotes Apoptosis of Colorectal Cancer Cells
    Anticancer research, 2018, Volume: 38, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Humans; Melatonin;

2018
Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo.
    International journal of molecular sciences, 2018, Dec-10, Volume: 19, Issue:12

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Cycle; Cell Movement; Cell Proliferation; Colorectal Neopla

2018
Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells.
    Carcinogenesis, 2019, 05-14, Volume: 40, Issue:3

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; D

2019
Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells.
    Journal of pineal research, 2014, Volume: 56, Issue:3

    Topics: Animals; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; C

2014
Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation.
    Journal of pineal research, 2015, Volume: 58, Issue:4

    Topics: Acetylation; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Chroma

2015
Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer.
    Molecular carcinogenesis, 2012, Volume: 51, Issue:8

    Topics: Aged; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relat

2012
The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells.
    Drug and chemical toxicology, 2013, Volume: 36, Issue:3

    Topics: Adenocarcinoma; Adult; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcin

2013
[Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients].
    Advances in gerontology = Uspekhi gerontologii, 2012, Volume: 25, Issue:2

    Topics: Adult; Age Factors; Aged; Chronobiology Disorders; Circadian Rhythm; Colorectal Neoplasms; Female; H

2012
Night-shift work and risk of colorectal cancer in the nurses' health study.
    Journal of the National Cancer Institute, 2003, Jun-04, Volume: 95, Issue:11

    Topics: Adult; Aged; Bias; Case-Control Studies; Colorectal Neoplasms; Female; Health Surveys; Humans; Life

2003
Circadian fluctuations of melatonin, tumor necrosis factor-alpha and its soluble receptors in the circulation of patients with advanced gastrointestinal cancer.
    Journal of experimental & clinical cancer research : CR, 2003, Volume: 22, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Antigens, CD; Circadian Rhythm; Colorectal Neoplasms; Enzyme-Link

2003
Night shifts and colorectal cancer risk.
    Mayo Clinic health letter (English ed.), 2005, Volume: 23, Issue:5

    Topics: Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Lighting; Melatonin; Nursing; Time Factors;

2005
Does the month of diagnosis affect survival of cancer patients?
    British journal of cancer, 1993, Volume: 67, Issue:4

    Topics: Breast Neoplasms; Colorectal Neoplasms; Female; Humans; Incidence; Melatonin; Pineal Gland; Prognosi

1993
[Melatonin and serotonin in inflammatory colon diseases and colorectal neoplasms].
    Klinicheskaia meditsina, 2000, Volume: 78, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; APUD Cells; Biomarkers, Tumor; Biopsy; Colitis; Colorectal

2000
Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status.
    Chronobiology international, 2002, Volume: 19, Issue:1

    Topics: Adult; Aged; Biomarkers; Circadian Rhythm; Colorectal Neoplasms; Female; Humans; Hydrocortisone; Kar

2002
Circadian rhythm of melatonin in patients with colorectal carcinoma.
    Neuro endocrinology letters, 2002, Volume: 23, Issue:3

    Topics: Adenocarcinoma; Aged; Circadian Rhythm; Colorectal Neoplasms; Female; Humans; Male; Melatonin; Middl

2002
Neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin as a second-line treatment in metastatic colorectal carcinoma.
    Tumori, 1992, Dec-31, Volume: 78, Issue:6

    Topics: Adult; Aged; Biopterins; Carcinoma; Colorectal Neoplasms; Combined Modality Therapy; Eosinophils; Fe

1992
A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates.
    Tumori, 1990, Feb-28, Volume: 76, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance; Female; Fluorouracil; Fol

1990