melatonin has been researched along with Colitis Gravis in 22 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions." | 6.55 | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. ( Alatorre-Jiménez, MA; Antoñanzas-Lombarte, Á; Buisac-Ramón, C; Castán-Ruiz, S; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Ochoa-Moneo, P; Reiter, RJ; Rivas-Jiménez, M; Tan, DX, 2017) |
| "The available ulcerative colitis drugs exhibit limited outcomes and adverse side effects." | 5.72 | Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats. ( Ahmed, O; Elamir, A; Farid, A, 2022) |
| "Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions." | 2.55 | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. ( Alatorre-Jiménez, MA; Antoñanzas-Lombarte, Á; Buisac-Ramón, C; Castán-Ruiz, S; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Ochoa-Moneo, P; Reiter, RJ; Rivas-Jiménez, M; Tan, DX, 2017) |
| "Melatonin has beneficial effects against UC in experimental and clinical studies because of its ability to modulate several molecular pathways of inflammation, oxidative stress, fibrosis, and cellular injury." | 2.50 | A review of the use of melatonin in ulcerative colitis: experimental evidence and new approaches. ( Jena, G; Trivedi, PP, 2014) |
| "The available ulcerative colitis drugs exhibit limited outcomes and adverse side effects." | 1.72 | Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats. ( Ahmed, O; Elamir, A; Farid, A, 2022) |
| "Melatonin has emerged as a potent anti-inflammatory agent." | 1.72 | Colon targeted chitosan-melatonin nanotherapy for preclinical Inflammatory Bowel Disease. ( Choudhury, SR; Guchhait, P; Gupta, S; Karmakar, S; Mohanbhai, SJ; Sardoiwala, MN; Sharma, SS; Shrimali, N, 2022) |
| "Melatonin treatment mitigated Oxa-induced colitis by suppressing type 2 immune response." | 1.62 | Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner. ( Cui, YY; Feng, BC; Jin, BY; Kou, GJ; Li, LX; Li, SY; Li, YQ; Liu, J; Shen, J; Yuan, X; Zhai, YJ; Zhao, ZX; Zheng, MQ; Zhou, RC; Zuo, XL, 2021) |
| "Microbial dysbiosis has long been postulated to be associated with the pathogenesis of inflammatory bowel disease (IBD)." | 1.56 | Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling. ( Cheon, JH; Kim, S; Kim, SW; Park, YS; Son, M, 2020) |
| "Melatonin IR was also seen in pancreas islets." | 1.42 | Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. ( Cunningham, JL; Hellström, PM; Söderquist, F, 2015) |
| "Melatonin treatment led to mucosal healing and reduced ulcerative colitis-induced elevated gut permeability and reduced the plasma LPS level, systemic inflammation, and genotoxicity." | 1.39 | Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms. ( Jena, GB; Trivedi, PP, 2013) |
| "Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals." | 1.37 | Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. ( Aktolga, S; Cetinkaya, A; Dorko, K; Gramignoli, R; Marongiu, F; Tahan, G; Tahan, V, 2011) |
| "Therapy of uncomplicated nonspecific ulcerative colitis with artrofoon effectively reduces the duration and number of relapses." | 1.35 | Artrofoon as alternative preparation in the treatment of uncomplicated forms of nonspecific ulcerative colitis. ( Osadchuk, AM; Osadchuk, MA, 2009) |
| "Melatonin seems to be a part of anti-inflammatory response and its high level may appease the course of UC." | 1.34 | [24-hour urinary 6-hydroxymelatonin sulfate excretion in patients with ulcerative colitis]. ( Boznańska, P; Smigielski, J; Stec-Michalska, K; Stepień, A; Szadkowski, K; Wichan, P; Wiśniewska-Jarosńska, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, ZX | 1 |
| Yuan, X | 1 |
| Cui, YY | 1 |
| Liu, J | 2 |
| Shen, J | 1 |
| Jin, BY | 1 |
| Feng, BC | 1 |
| Zhai, YJ | 1 |
| Zheng, MQ | 1 |
| Kou, GJ | 1 |
| Zhou, RC | 1 |
| Li, LX | 1 |
| Zuo, XL | 1 |
| Li, SY | 1 |
| Li, YQ | 1 |
| Ahmed, O | 1 |
| Farid, A | 1 |
| Elamir, A | 1 |
| Mohanbhai, SJ | 1 |
| Sardoiwala, MN | 1 |
| Gupta, S | 1 |
| Shrimali, N | 1 |
| Choudhury, SR | 1 |
| Sharma, SS | 1 |
| Guchhait, P | 1 |
| Karmakar, S | 1 |
| Kim, SW | 1 |
| Kim, S | 1 |
| Son, M | 1 |
| Cheon, JH | 1 |
| Park, YS | 1 |
| Chojnacki, C | 2 |
| Wiśniewska-Jarosińska, M | 2 |
| Kulig, G | 1 |
| Majsterek, I | 1 |
| Reiter, RJ | 2 |
| Chojnacki, J | 2 |
| Trivedi, PP | 2 |
| Jena, GB | 1 |
| Jena, G | 1 |
| Parekh, PJ | 1 |
| Oldfield Iv, EC | 1 |
| Challapallisri, V | 1 |
| Ware, JC | 1 |
| Johnson, DA | 1 |
| Söderquist, F | 1 |
| Hellström, PM | 1 |
| Cunningham, JL | 1 |
| Esteban-Zubero, E | 1 |
| López-Pingarrón, L | 1 |
| Alatorre-Jiménez, MA | 1 |
| Ochoa-Moneo, P | 1 |
| Buisac-Ramón, C | 1 |
| Rivas-Jiménez, M | 1 |
| Castán-Ruiz, S | 1 |
| Antoñanzas-Lombarte, Á | 1 |
| Tan, DX | 1 |
| García, JJ | 1 |
| Terry, PD | 1 |
| Villinger, F | 1 |
| Bubenik, GA | 1 |
| Sitaraman, SV | 1 |
| Osadchuk, AM | 1 |
| Osadchuk, MA | 1 |
| Tahan, G | 1 |
| Gramignoli, R | 1 |
| Marongiu, F | 1 |
| Aktolga, S | 1 |
| Cetinkaya, A | 1 |
| Tahan, V | 1 |
| Dorko, K | 1 |
| Rakhimova, OIu | 1 |
| Paĭzullaeva, ZK | 1 |
| Aleksandrov, VB | 1 |
| Swanson, GR | 1 |
| Burgess, HJ | 1 |
| Keshavarzian, A | 1 |
| Chen, M | 1 |
| Mei, Q | 1 |
| Xu, J | 1 |
| Lu, C | 1 |
| Fang, H | 1 |
| Liu, X | 1 |
| Walecka-Kapica, E | 1 |
| Klupinska, G | 1 |
| Jaworek, J | 1 |
| Mann, S | 1 |
| Jan, JE | 1 |
| Freeman, RD | 1 |
| Li, JH | 1 |
| Yu, JP | 1 |
| Yu, HG | 1 |
| Xu, XM | 1 |
| Yu, LL | 1 |
| Luo, HS | 1 |
| Boznańska, P | 1 |
| Wichan, P | 1 |
| Stepień, A | 1 |
| Wiśniewska-Jarosńska, M | 1 |
| Smigielski, J | 1 |
| Szadkowski, K | 1 |
| Stec-Michalska, K | 1 |
| Maldonado, MD | 1 |
| Calvo, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478] | Phase 2 | 3 participants (Actual) | Interventional | 2009-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for melatonin and Colitis Gravis
| Article | Year |
|---|---|
A review of the use of melatonin in ulcerative colitis: experimental evidence and new approaches.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Humans; Melatonin | 2014 |
Melatonin's role as a co-adjuvant treatment in colonic diseases: A review.
Topics: Animals; Cell Proliferation; Colitis; Colitis, Ulcerative; Colonic Diseases; Enterocolitis, Necrotiz | 2017 |
Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research.
Topics: Animals; Colitis, Ulcerative; Humans; Melatonin | 2009 |
Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
Topics: Animals; Circadian Clocks; Circadian Rhythm; Colitis, Ulcerative; Crohn Disease; Humans; Inflammator | 2011 |
1 trial available for melatonin and Colitis Gravis
| Article | Year |
|---|---|
Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; C-Reactive Protein; Colitis, Ulcerativ | 2011 |
17 other studies available for melatonin and Colitis Gravis
| Article | Year |
|---|---|
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.
Topics: Animals; Colitis, Ulcerative; Colon; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; | 2021 |
Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats.
Topics: Acetic Acid; Animals; Antioxidants; Colitis; Colitis, Ulcerative; Colon; Glutathione; Melatonin; Rat | 2022 |
Colon targeted chitosan-melatonin nanotherapy for preclinical Inflammatory Bowel Disease.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Colitis, Ulcerative; Inflammatory Bowel Diseases; Melat | 2022 |
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.
Topics: Animals; Bacteroidetes; Cell Differentiation; Colitis, Ulcerative; Dextran Sulfate; Disease Models, | 2020 |
Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis.
Topics: Acetylserotonin O-Methyltransferase; Adult; Case-Control Studies; Cell Proliferation; Colitis, Ulcer | 2013 |
Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Biomarkers; Colitis, Ulcerative; Colon; Deoxygua | 2013 |
Sleep disorders and inflammatory disease activity: chicken or the egg?
Topics: Animals; C-Reactive Protein; Circadian Rhythm; Clinical Trials as Topic; Colitis, Ulcerative; Crohn | 2015 |
Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2.
Topics: Adult; Case-Control Studies; Colitis, Ulcerative; Enterochromaffin Cells; Gastrointestinal Tract; Ge | 2015 |
Artrofoon as alternative preparation in the treatment of uncomplicated forms of nonspecific ulcerative colitis.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Colitis, Ulcerative; Female; Humans; Male; Mast Cel | 2009 |
Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis, Ulcerative; Co | 2011 |
[Neuroendocrine changes in patients with inflammatory diseases and colonic cancer].
Topics: Apoptosis; Cell Proliferation; Colitis, Ulcerative; Colonic Neoplasms; Crohn Disease; Free Radicals; | 2010 |
Detection of melatonin and homocysteine simultaneously in ulcerative colitis.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Enzyme-Linke | 2012 |
Melatonin for ulcerative colitis?
Topics: Adjuvants, Immunologic; Colitis, Ulcerative; Humans; Male; Melatonin; Middle Aged | 2003 |
Re: Mann--melatonin for ulcerative colitis?
Topics: Adjuvants, Immunologic; Child; Colitis, Ulcerative; Digestive System Diseases; Humans; Melatonin; Sl | 2003 |
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Down-Regulation; Female; I-kappa B Proteins; Inflammatio | 2005 |
[24-hour urinary 6-hydroxymelatonin sulfate excretion in patients with ulcerative colitis].
Topics: Adolescent; Adult; Colitis, Ulcerative; Colonoscopy; Enzyme-Linked Immunosorbent Assay; Female; Huma | 2007 |
Melatonin usage in ulcerative colitis: a case report.
Topics: Colitis, Ulcerative; Humans; Male; Melatonin; Middle Aged | 2008 |