melatonin has been researched along with Cognitive Decline in 54 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment." | 9.34 | Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. ( Biazús, JV; Caumo, W; Fregni, F; Palmer, ACS; Santos, V; Souza, A; Torres, ILS; Zortea, M, 2020) |
| "The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia." | 9.24 | The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017) |
| " Amelioration of cognitive dysfunction may be facilitated during benzodiazepine tapering by add-on melatonin due to its anti-inflammatory and neuroprotective properties." | 9.24 | Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. ( Baandrup, L; Fagerlund, B; Glenthoj, B, 2017) |
| " A wide array of biochemical processes underlie MDD presentations and their shift to a recurrent, neuroprogressive course, including: increased immune-inflammation, tryptophan catabolites (TRYCATs), mitochondrial dysfunction, aryl hydrocarbonn receptor activation, and oxidative and nitrosative stress (O&NS), as well as decreased sirtuins and melatonergic pathway activity." | 8.98 | Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. ( Anderson, G, 2018) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 8.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "In the acute phase of ischemic stroke 73 patients aged from 61 to 86 years and 47 patients aged 36 to 60 years underwent a comprehensive neuropsychological testing, evaluation of the concentration of 6-sulfatoximelatonin 6-sulfatoximelatonin in the night urine and brain MRI morphometry in some patients." | 7.83 | [The role of melatonin in the development of post-stroke cognitive impairment in elderly patients in comparison with middle-aged patients]. ( Drobakha, VE; Kulesh, AA; Shestakov, VV, 2016) |
| "Depression is a common chronic psychiatric illness, which is resistant to medical treatments." | 5.91 | Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. ( Fang, Y; Hao, J; He, Y; Huang, H; Li, R; Liu, X; Ran, L; Wang, M; Wang, W; Wang, X; Yao, D, 2023) |
| " Chronic use of METH is associated with cognitive impairments in both human and animal studies, but the underlying mechanism remains unclear." | 5.62 | Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus. ( Chancharoen, P; Govitrapong, P; Lwin, T; Mukda, S; Ngampramuan, S; Pinyomahakul, J; Veschsanit, N; Viwatpinyo, K; Yang, JL, 2021) |
| "Melatonin was administered i." | 5.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Melatonin has anti-inflammatory, anti-oxidative and anti-apoptotic effects against various diseases." | 5.56 | Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. ( Bai, YP; Chen, Y; Feng, JG; Jia, J; Liu, KX; Yang, B; Zhang, LY; Zhou, J, 2020) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 5.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 5.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| "Melatonin treatment significantly improved tGCI-induced cognitive impairment." | 5.48 | Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. ( Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, DW; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Lee, YL; Park, JH; Won, MH; Yan, BC, 2018) |
| "This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment." | 5.34 | Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. ( Biazús, JV; Caumo, W; Fregni, F; Palmer, ACS; Santos, V; Souza, A; Torres, ILS; Zortea, M, 2020) |
| "The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia." | 5.24 | The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017) |
| " Amelioration of cognitive dysfunction may be facilitated during benzodiazepine tapering by add-on melatonin due to its anti-inflammatory and neuroprotective properties." | 5.24 | Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. ( Baandrup, L; Fagerlund, B; Glenthoj, B, 2017) |
| " A wide array of biochemical processes underlie MDD presentations and their shift to a recurrent, neuroprogressive course, including: increased immune-inflammation, tryptophan catabolites (TRYCATs), mitochondrial dysfunction, aryl hydrocarbonn receptor activation, and oxidative and nitrosative stress (O&NS), as well as decreased sirtuins and melatonergic pathway activity." | 4.98 | Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. ( Anderson, G, 2018) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 4.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "Objective To investigate the changes of serum melatonin(MLT)and glutathione(GSH)levels in patients with Parkinson's disease(PD)and explore their relationships with disease severity,cognitive dysfunction,and sleep disorders." | 3.91 | [Correlations of Melatonin and Glutathione Levels with Oxidative Stress Mechanism in Parkinson's Disease]. ( Bai, HY; DU, M; Wei, HJ, 2019) |
| " Previous studies have identified that melatonin improves cognitive dysfunction in animal models." | 3.88 | Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus. ( Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, H; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Park, JH; Song, M; Won, MH; Yan, BC, 2018) |
| "In the acute phase of ischemic stroke 73 patients aged from 61 to 86 years and 47 patients aged 36 to 60 years underwent a comprehensive neuropsychological testing, evaluation of the concentration of 6-sulfatoximelatonin 6-sulfatoximelatonin in the night urine and brain MRI morphometry in some patients." | 3.83 | [The role of melatonin in the development of post-stroke cognitive impairment in elderly patients in comparison with middle-aged patients]. ( Drobakha, VE; Kulesh, AA; Shestakov, VV, 2016) |
| "Melatonin has multiple proposed therapeutic benefits including antioxidant properties, synchronisation of the circadian system and lowering of blood pressure." | 3.01 | Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study. ( Chapman, JL; Duffy, SL; Gordon, CJ; Grunstein, RR; Hoyos, CM; La Monica, HM; Lewis, SJG; Marshall, NS; Menczel Schrire, Z; Mowszowski, L; Naismith, SL; Phillips, CL; Saini, B, 2021) |
| " No withdrawal was observed due to the drugs' adverse effects." | 2.94 | Comparison of the efficacy and safety of melatonin and memantine in the alleviation of cognitive impairments induced by electroconvulsive therapy: A randomized clinical trial. ( Abbasinazari, M; Badri, T; Ghassab-Sahebkar, A; Keshvari, N; Qobadighadikolaei, R; Sarraf, N, 2020) |
| "BACKGROUND Alzheimer's disease (AD) is a degenerative disease that is characterized by massive neuron devastations in the hippocampus and cortex." | 2.94 | Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study. ( Geng, Y; Hu, B; Sun, H; Xu, L; Yu, H, 2020) |
| "Memantine is an uncompetitive N-methyl-d-aspartic acid receptor antagonist and is approved for the management of moderate-to-severe AD." | 2.53 | Pharmacotherpy and Alzheimer's Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach. ( Daulatzai, MA, 2016) |
| "Search terms were "Alzheimer" "mild cognitive impairment" and "melatonin"." | 2.47 | The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease. ( Brusco, LI; Cardinali, DP; Furio, AM, 2011) |
| "Treatment with melatonin during withdrawal restored METH-induced mitochondria and synaptic impairments." | 1.91 | Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal. ( Chetsawang, B; Cornish, JL; Na Nakorn, P; Ngampramuan, S; Panmanee, J; Pannengpetch, S; Polvat, T; Prasertporn, T; Suwanjang, W, 2023) |
| "Chronic sleep deprivation (CSD) model was established using the MMPM method." | 1.91 | Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation-related cognitive impairment by alleviating oxidative stress. ( Hu, Y; Yang, G; Yin, J, 2023) |
| "Depression is a common chronic psychiatric illness, which is resistant to medical treatments." | 1.91 | Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. ( Fang, Y; Hao, J; He, Y; Huang, H; Li, R; Liu, X; Ran, L; Wang, M; Wang, W; Wang, X; Yao, D, 2023) |
| "Overweight and obesity are associated with an increased risk of developing dementia and cognitive deficits." | 1.72 | Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. ( Abedi, A; Amani, M; Mansouri, S; Mohammadi, P; Salari, AA, 2022) |
| "Melatonin was administered i." | 1.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Melatonin has been well documented for its neuroprotective role through inhibiting oxidative stress against traumatic brain injury (TBI)." | 1.62 | Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. ( Cai, K; Cao, R; Chen, M; Chen, Q; Li, L; Lu, J; Sheng, L; Wang, Y; Xu, G; Zhang, W, 2021) |
| " Chronic use of METH is associated with cognitive impairments in both human and animal studies, but the underlying mechanism remains unclear." | 1.62 | Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus. ( Chancharoen, P; Govitrapong, P; Lwin, T; Mukda, S; Ngampramuan, S; Pinyomahakul, J; Veschsanit, N; Viwatpinyo, K; Yang, JL, 2021) |
| "Having a history of optic neuritis is associated with improved sleep quality and executive functions but increased daytime sleepiness." | 1.56 | Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event. ( Akbayır, E; Arsoy, E; Benbir, G; Gencer, M; Karadeniz, D; Özyurt, S; Turan, S; Türkoğlu, R; Tüzün, E; Yılmaz, V, 2020) |
| "Melatonin has anti-inflammatory, anti-oxidative and anti-apoptotic effects against various diseases." | 1.56 | Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. ( Bai, YP; Chen, Y; Feng, JG; Jia, J; Liu, KX; Yang, B; Zhang, LY; Zhou, J, 2020) |
| "As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats." | 1.56 | Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. ( Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P, 2020) |
| "Melatonin was administered daily in drinking water (4 mg/kg b." | 1.56 | Melatonin mitigates hippocampal and cognitive impairments caused by prenatal irradiation. ( Jendželovský, R; Kisková, T; Pipová Kokošová, N; Račeková, E; Šmajda, B; Štafuriková, A; Vilhanová, K, 2020) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 1.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 1.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| "Melatonin treatment significantly improved tGCI-induced cognitive impairment." | 1.48 | Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. ( Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, DW; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Lee, YL; Park, JH; Won, MH; Yan, BC, 2018) |
| "Melatonin is a potent antioxidant with anti-inflammatory and neuroprotective properties." | 1.48 | Voluntary alcohol consumption exacerbated high fat diet-induced cognitive deficits by NF-κB-calpain dependent apoptotic cell death in rat hippocampus: Ameliorative effect of melatonin. ( Choubey, P; Dwivedi, DK; Jangra, A; Kumar, D; Kwatra, M; Lahkar, M; Pandey, SN, 2018) |
| "Melatonin (MTG) plays critical roles in circadian rhythm disorders, Alzheimer's disease, and other neurological disorders." | 1.48 | Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder. ( Hahm, DH; Lee, B; Lee, H; Shim, I, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (42.59) | 24.3611 |
| 2020's | 31 (57.41) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, R | 1 |
| Li, L | 1 |
| Zhang, W | 2 |
| Lu, J | 1 |
| Wang, Y | 3 |
| Chen, Q | 1 |
| Chen, M | 2 |
| Sheng, L | 1 |
| Cai, K | 1 |
| Xu, G | 1 |
| Roy, J | 2 |
| Wong, KY | 2 |
| Aquili, L | 2 |
| Uddin, MS | 1 |
| Heng, BC | 2 |
| Tipoe, GL | 1 |
| Wong, KH | 1 |
| Fung, ML | 2 |
| Lim, LW | 2 |
| Zhong, X | 1 |
| Chen, B | 1 |
| Li, Z | 1 |
| Lin, R | 1 |
| Ruan, S | 1 |
| Wang, F | 1 |
| Liang, H | 1 |
| Tao, J | 1 |
| Mansouri, S | 1 |
| Salari, AA | 1 |
| Abedi, A | 1 |
| Mohammadi, P | 1 |
| Amani, M | 1 |
| Chunchai, T | 3 |
| Pintana, H | 3 |
| Arinno, A | 3 |
| Ongnok, B | 3 |
| Pantiya, P | 3 |
| Khuanjing, T | 3 |
| Prathumsap, N | 3 |
| Maneechote, C | 3 |
| Chattipakorn, N | 3 |
| Chattipakorn, SC | 3 |
| Hu, Y | 1 |
| Yin, J | 1 |
| Yang, G | 1 |
| Wu, J | 1 |
| Hao, Z | 1 |
| Yan, D | 1 |
| Meng, J | 1 |
| Ma, H | 1 |
| Wang, X | 2 |
| Wang, Z | 1 |
| Cao, J | 1 |
| Dong, Y | 1 |
| Chen, Y | 2 |
| Abulafia, C | 1 |
| Vidal, MF | 1 |
| Olivar, N | 1 |
| Odzak, A | 1 |
| Brusco, I | 1 |
| Guinjoan, SM | 1 |
| Cardinali, DP | 3 |
| Vigo, DE | 1 |
| Rubinstein, MR | 1 |
| Burgueño, AL | 1 |
| Quiroga, S | 1 |
| Wald, MR | 1 |
| Genaro, AM | 1 |
| Polvat, T | 1 |
| Prasertporn, T | 1 |
| Na Nakorn, P | 1 |
| Pannengpetch, S | 1 |
| Suwanjang, W | 1 |
| Panmanee, J | 1 |
| Ngampramuan, S | 2 |
| Cornish, JL | 1 |
| Chetsawang, B | 1 |
| Yao, D | 1 |
| Li, R | 1 |
| Hao, J | 1 |
| Huang, H | 1 |
| Ran, L | 1 |
| Fang, Y | 1 |
| He, Y | 1 |
| Wang, W | 1 |
| Liu, X | 1 |
| Wang, M | 1 |
| Zou, X | 1 |
| Zhang, X | 1 |
| Qiang, T | 1 |
| Hu, X | 1 |
| Zhang, L | 2 |
| Türkoğlu, R | 1 |
| Benbir, G | 1 |
| Özyurt, S | 1 |
| Arsoy, E | 1 |
| Akbayır, E | 1 |
| Turan, S | 1 |
| Karadeniz, D | 1 |
| Yılmaz, V | 1 |
| Gencer, M | 1 |
| Tüzün, E | 1 |
| De Butte, M | 1 |
| Gieseking, B | 1 |
| Hosseini, L | 1 |
| Farokhi-Sisakht, F | 1 |
| Badalzadeh, R | 1 |
| Khabbaz, A | 1 |
| Mahmoudi, J | 1 |
| Sadigh-Eteghad, S | 1 |
| Pipová Kokošová, N | 1 |
| Kisková, T | 1 |
| Vilhanová, K | 1 |
| Štafuriková, A | 1 |
| Jendželovský, R | 1 |
| Račeková, E | 1 |
| Šmajda, B | 1 |
| Sarraf, N | 1 |
| Badri, T | 1 |
| Keshvari, N | 1 |
| Ghassab-Sahebkar, A | 1 |
| Qobadighadikolaei, R | 1 |
| Abbasinazari, M | 1 |
| Sirichoat, A | 1 |
| Suwannakot, K | 1 |
| Chaisawang, P | 1 |
| Pannangrong, W | 1 |
| Aranarochana, A | 1 |
| Wigmore, P | 1 |
| Welbat, JU | 1 |
| Palmer, ACS | 1 |
| Zortea, M | 1 |
| Souza, A | 1 |
| Santos, V | 1 |
| Biazús, JV | 1 |
| Torres, ILS | 1 |
| Fregni, F | 1 |
| Caumo, W | 1 |
| Xu, L | 1 |
| Yu, H | 1 |
| Sun, H | 1 |
| Hu, B | 1 |
| Geng, Y | 1 |
| Yang, B | 1 |
| Zhang, LY | 1 |
| Bai, YP | 1 |
| Jia, J | 1 |
| Feng, JG | 1 |
| Liu, KX | 1 |
| Zhou, J | 1 |
| Lamtai, M | 1 |
| Azirar, S | 1 |
| Zghari, O | 1 |
| Ouakki, S | 1 |
| El Hessni, A | 1 |
| Mesfioui, A | 1 |
| Ouichou, A | 1 |
| Mihardja, M | 1 |
| Chan, YS | 1 |
| Lwin, T | 1 |
| Yang, JL | 1 |
| Viwatpinyo, K | 1 |
| Chancharoen, P | 1 |
| Veschsanit, N | 1 |
| Pinyomahakul, J | 1 |
| Govitrapong, P | 2 |
| Mukda, S | 1 |
| Li, J | 1 |
| Wu, G | 1 |
| Song, W | 1 |
| Liu, Y | 1 |
| Han, Z | 1 |
| Shen, Z | 1 |
| Li, Y | 1 |
| Albazal, A | 1 |
| Delshad, AA | 1 |
| Roghani, M | 1 |
| Menczel Schrire, Z | 1 |
| Phillips, CL | 1 |
| Duffy, SL | 1 |
| Marshall, NS | 1 |
| Mowszowski, L | 1 |
| La Monica, HM | 1 |
| Gordon, CJ | 1 |
| Chapman, JL | 1 |
| Saini, B | 1 |
| Lewis, SJG | 1 |
| Naismith, SL | 2 |
| Grunstein, RR | 1 |
| Hoyos, CM | 1 |
| Cui, Y | 2 |
| Yang, M | 1 |
| Ren, J | 1 |
| Lin, P | 1 |
| Cui, C | 1 |
| Song, J | 2 |
| He, Q | 1 |
| Hu, H | 1 |
| Wang, K | 1 |
| Sun, Y | 1 |
| Panmak, P | 1 |
| Nopparat, C | 1 |
| Permpoonpattana, K | 1 |
| Namyen, J | 1 |
| Nous, A | 1 |
| Wittens, MMJ | 1 |
| Vermeiren, Y | 1 |
| De Deyn, PP | 1 |
| Van Broeckhoven, C | 1 |
| Nagels, G | 1 |
| Smolders, I | 1 |
| Engelborghs, S | 1 |
| Anderson, G | 1 |
| Fan, Y | 1 |
| Yuan, L | 1 |
| Ji, M | 1 |
| Yang, J | 1 |
| Gao, D | 1 |
| Kulesh, AA | 1 |
| Drobakha, VE | 1 |
| Shestakov, VV | 1 |
| Chen, BH | 4 |
| Park, JH | 4 |
| Kim, DW | 2 |
| Park, J | 1 |
| Choi, SY | 2 |
| Kim, IH | 1 |
| Cho, JH | 3 |
| Lee, TK | 4 |
| Lee, JC | 4 |
| Lee, CH | 3 |
| Hwang, IK | 4 |
| Kim, YM | 3 |
| Yan, BC | 3 |
| Kang, IJ | 4 |
| Shin, BN | 2 |
| Lee, YL | 3 |
| Shin, MC | 2 |
| Lee, YJ | 2 |
| Jeon, YH | 2 |
| Won, MH | 4 |
| Ahn, JH | 4 |
| Shapiro, EG | 2 |
| Jones, SA | 1 |
| Escolar, ML | 2 |
| Delaney, KA | 1 |
| Mitchell, JJ | 1 |
| Hong, S | 1 |
| Song, M | 1 |
| Kim, H | 1 |
| Chu, S | 1 |
| Qian, Y | 1 |
| Li, X | 1 |
| Xu, F | 1 |
| Shao, X | 1 |
| Ma, Z | 1 |
| Xia, T | 1 |
| Gu, X | 1 |
| Lee, B | 1 |
| Shim, I | 1 |
| Lee, H | 1 |
| Hahm, DH | 1 |
| Spinedi, E | 1 |
| Dwivedi, DK | 1 |
| Kumar, D | 1 |
| Kwatra, M | 1 |
| Pandey, SN | 1 |
| Choubey, P | 1 |
| Lahkar, M | 1 |
| Jangra, A | 1 |
| Xu, J | 1 |
| Gao, H | 1 |
| Rong, S | 1 |
| Yang, W | 1 |
| Ma, C | 1 |
| Huang, Q | 1 |
| Deng, Q | 1 |
| Huang, F | 1 |
| Wei, HJ | 1 |
| DU, M | 1 |
| Bai, HY | 1 |
| Hickie, IB | 1 |
| Terpening, Z | 1 |
| Rajaratnam, SM | 1 |
| Rajaratnam, SW | 1 |
| Hodges, JR | 1 |
| Bolitho, S | 1 |
| Rogers, NL | 1 |
| Lewis, SJ | 1 |
| Sirin, FB | 1 |
| Kumbul Doğuç, D | 1 |
| Vural, H | 1 |
| Eren, I | 1 |
| Inanli, I | 1 |
| Sütçü, R | 1 |
| Delibaş, N | 1 |
| Daulatzai, MA | 1 |
| Baandrup, L | 1 |
| Fagerlund, B | 1 |
| Glenthoj, B | 1 |
| Furio, AM | 1 |
| Brusco, LI | 1 |
| Rondanelli, M | 2 |
| Opizzi, A | 1 |
| Faliva, M | 2 |
| Mozzoni, M | 1 |
| Antoniello, N | 1 |
| Cazzola, R | 2 |
| Savarè, R | 1 |
| Cerutti, R | 1 |
| Grossi, E | 1 |
| Cestaro, B | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Safety and Efficacy of Fecal Microbiota Transplantation in Patients With Chronic Insomnia Disorder[NCT05917379] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2023-07-01 | Not yet recruiting | ||
| Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950] | 104 participants (Anticipated) | Interventional | 2017-06-26 | Recruiting | |||
| A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos[NCT05030948] | 236 participants (Actual) | Interventional | 2021-08-27 | Active, not recruiting | |||
| Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)[NCT05216614] | Phase 2 | 0 participants (Actual) | Interventional | 2021-12-14 | Withdrawn (stopped due to Unable to obtain investigational product) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for melatonin and Cognitive Decline
| Article | Year |
|---|---|
Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Humans; Melatonin; Neuronal Plasticity; Sleep | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Current Understanding of the Roles of Gut-Brain Axis in the Cognitive Deficits Caused by Perinatal Stress Exposure.
Topics: Brain-Gut Axis; Cognition; Cognitive Dysfunction; Female; Gastrointestinal Microbiome; Humans; Infan | 2023 |
Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Circadian Rhythm; Cognitive Dysfunction; D | 2020 |
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition.
Topics: Cognition; Cognitive Dysfunction; Depressive Disorder, Major; DNA Repair; Humans; Inflammation; Mela | 2018 |
Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations - Neurological signs and symptoms.
Topics: Brain; Child; Child Behavior; Child Development; Child, Preschool; Cognitive Dysfunction; Congresses | 2017 |
Assessments of neurocognitive and behavioral function in the mucopolysaccharidoses.
Topics: Brain; Child; Child Behavior; Child Development; Child, Preschool; Cognitive Dysfunction; Congresses | 2017 |
Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer's Disease and Melatonin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Humans; Melatonin; | 2019 |
Pharmacotherpy and Alzheimer's Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach.
Topics: Alzheimer Disease; Animals; Benzhydryl Compounds; Cognitive Dysfunction; Humans; Melatonin; Memantin | 2016 |
The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease.
Topics: Alzheimer Disease; Circadian Rhythm; Cognitive Dysfunction; Female; Humans; Male; Melatonin; Sleep D | 2011 |
9 trials available for melatonin and Cognitive Decline
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Comparison of the efficacy and safety of melatonin and memantine in the alleviation of cognitive impairments induced by electroconvulsive therapy: A randomized clinical trial.
Topics: Adult; Aged; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Electroconvulsive Therapy | 2020 |
Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Brain-Derived Neurotrophic Factor; Breast Neoplasms; | 2020 |
Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; China; Cognitive Dysf | 2020 |
Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study.
Topics: Aged; Australia; Brain; Cognitive Dysfunction; Dietary Supplements; Double-Blind Method; Feasibility | 2021 |
The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; China; Circadian Rhythm | 2017 |
Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo.
Topics: Adult; Antioxidants; Benzodiazepines; Bipolar Disorder; Cognitive Dysfunction; Double-Blind Method; | 2017 |
Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment.
Topics: Aged, 80 and over; Attention; Body Composition; Cognition; Cognitive Dysfunction; Diet; Dietary Supp | 2012 |
Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Antioxidants; Blood Specimen Collection; Chemistry, Physical; Cognitive Dys | 2012 |
36 other studies available for melatonin and Cognitive Decline
| Article | Year |
|---|---|
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation.
Topics: Animals; Astrocytes; Brain Injuries, Traumatic; Cognitive Dysfunction; Male; Melatonin; Mice; Neurop | 2021 |
Electroacupuncture Ameliorates Cognitive Impairment Through the Inhibition of NLRP3 Inflammasome Activation by Regulating Melatonin-Mediated Mitophagy in Stroke Rats.
Topics: Animals; Brain Ischemia; Cognitive Dysfunction; Electroacupuncture; Infarction, Middle Cerebral Arte | 2022 |
Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; Diet, High-Fat; Hippoc | 2022 |
Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain.
Topics: Animals; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction; Doxorubicin; Encephalitis | 2023 |
Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain.
Topics: Animals; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction; Doxorubicin; Encephalitis | 2023 |
Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain.
Topics: Animals; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction; Doxorubicin; Encephalitis | 2023 |
Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain.
Topics: Animals; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction; Doxorubicin; Encephalitis | 2023 |
Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation-related cognitive impairment by alleviating oxidative stress.
Topics: ARNTL Transcription Factors; bcl-2-Associated X Protein; Cognitive Dysfunction; Humans; Interleukin- | 2023 |
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Halogenated Diphenyl Ethers; Hippocampus; | 2023 |
Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation.
Topics: Animals; Butyrates; Clostridiales; Cognitive Dysfunction; Gastrointestinal Microbiome; Lipopolysacch | 2023 |
An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor.
Topics: Actigraphy; Circadian Rhythm; Cognitive Dysfunction; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2023 |
Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal.
Topics: Animals; Cognitive Dysfunction; Humans; Melatonin; Methamphetamine; Mice; Proteomics; Substance With | 2023 |
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; Cognitive Dysfunction; Depression; Melatonin | 2023 |
Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognition; Cognitive Dysfunction; Hippocampus; M | 2023 |
Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event.
Topics: Adult; Biomarkers; Cognitive Dysfunction; Disease Progression; Enzyme-Linked Immunosorbent Assay; Fe | 2020 |
Efficacy of a low-dose melatonin pretreatment in protecting against the neurobehavioral consequences of chronic hypoperfusion in middle-aged female rats.
Topics: Age Factors; Animals; Behavior, Animal; Cerebrovascular Circulation; Cognitive Dysfunction; Disease | 2020 |
Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus.
Topics: Adenosine Triphosphate; Aging; Animals; Apoptosis; Cognitive Dysfunction; Drug Synergism; Hippocampu | 2019 |
Melatonin mitigates hippocampal and cognitive impairments caused by prenatal irradiation.
Topics: Animals; Cognitive Dysfunction; Female; Hippocampus; Male; Melatonin; Neurogenesis; Neurons; Pregnan | 2020 |
Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats.
Topics: Animals; Antimetabolites; Biomarkers; Cell Proliferation; Cognitive Dysfunction; Dentate Gyrus; Doub | 2020 |
Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Cognitive Dysfunction; Cytokines; Intestinal Di | 2020 |
Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat.
Topics: Animals; Antioxidants; Cadmium; Cognitive Dysfunction; Female; Hippocampus; Lipid Peroxidation; Male | 2021 |
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System Stimulants; Cognitive Dysfunction; Hippoca | 2021 |
Prophylactic Melatonin Treatment Ameliorated Propofol-Induced Cognitive Dysfunction in Aged Rats.
Topics: Age Factors; Animals; Behavior, Animal; Cells, Cultured; Cognitive Dysfunction; Hippocampus; Male; M | 2021 |
Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation.
Topics: Acetylcholinesterase; Animals; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Diabetes Mel | 2021 |
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Inflammat | 2021 |
Melatonin protects against methamphetamine-induced Alzheimer's disease-like pathological changes in rat hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Central Nervous System Stimulants; | 2021 |
Serum Daytime Melatonin Levels Reflect Cerebrospinal Fluid Melatonin Levels in Alzheimer's Disease but Are Not Correlated with Cognitive Decline.
Topics: Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; | 2021 |
[The role of melatonin in the development of post-stroke cognitive impairment in elderly patients in comparison with middle-aged patients].
Topics: Age Factors; Aged; Aged, 80 and over; Cognition; Cognitive Dysfunction; Female; Hippocampus; Humans; | 2016 |
Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia.
Topics: Amnesia; Animals; Choline O-Acetyltransferase; Cognition; Cognitive Dysfunction; Disease Models, Ani | 2018 |
Effects of Scopolamine and Melatonin Cotreatment on Cognition, Neuronal Damage, and Neurogenesis in the Mouse Dentate Gyrus.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cognition; Cognitive Dysfunction; Dentate Gyrus; | 2018 |
Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; Demyelin | 2018 |
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Body Temperature; Circadian Rhythm; CLOCK Proteins; Cogniti | 2018 |
Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder.
Topics: Animals; Anti-Inflammatory Agents; Cognition; Cognitive Dysfunction; Cyclic AMP Response Element-Bin | 2018 |
Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cell Death; Cognitive Dysfuncti | 2018 |
Voluntary alcohol consumption exacerbated high fat diet-induced cognitive deficits by NF-κB-calpain dependent apoptotic cell death in rat hippocampus: Ameliorative effect of melatonin.
Topics: Acetylcholinesterase; Alcohol Drinking; Animals; Apoptosis; Calpain; Caspase 3; Cognitive Dysfunctio | 2018 |
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet.
Topics: Aging; Animals; Cholinergic Neurons; Cognitive Dysfunction; Dietary Fats; Female; Hippocampus; Insul | 2019 |
[Correlations of Melatonin and Glutathione Levels with Oxidative Stress Mechanism in Parkinson's Disease].
Topics: Case-Control Studies; Cognitive Dysfunction; Glutathione; Humans; Melatonin; Oxidative Stress; Parki | 2019 |
Circadian misalignment and sleep disruption in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Biomarkers; Circadian Rhythm; Cognitive Dysfunction; Female; Humans; Male; | 2014 |
Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Cognitive Dysfunction; | 2015 |