melatonin has been researched along with Cognition Disorders in 58 studies
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current review aims to examine melatonin therapy for both sleep disturbances and cognitive function in dementia." | 8.91 | Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials. ( Chen, SD; Dammer, EB; Li, CB; Wang, G; Wang, LL; Xu, G; Xu, J, 2015) |
| "To assess if high morning plasma melatonin concentrations were associated with delirium." | 7.85 | Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017) |
| "In this study, the relationship between the plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several intercellular interactions including inflammatory and immune responses, and early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined." | 7.81 | The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery. ( Akçalı, A; Ali Elçi, M; Deniz, H; Geyik, S; Hafız, E; Murat Geyik, A; Yiğiter, R, 2015) |
| "The content of 6-sulfatoximelatonin in daily urine and butyrylcholinesterase in blood serum was determined in the acute stage of ischemic stroke in 25 and 40 men, respectively." | 7.78 | [Secretion of melatonin and serum cholinesterase activity as biological markers of cognitive disorders in the acute stage of ischemic stroke]. ( Kulesh, AA; Shestakov, VV, 2012) |
| "Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are the most common central nervous system dysfunctions during the perioperative period." | 5.62 | Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction. ( Mu, S; Wu, A; Wu, Y, 2021) |
| "Diisononyl phthalate (DINP) is a plasticizer that is frequently used as a substitute for other plasticizers whose use is prohibited in certain products." | 5.42 | Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. ( Bornehag, CG; Guo, J; Liu, C; Liu, X; Lu, Y; Ma, P; Nanberg, E; Wu, J; Wu, Y; Yan, B; Yang, X; Zhang, Y, 2015) |
| "Melatonin was effective in the memory facilitating effects only when administered in the afternoon." | 5.39 | A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease. ( He, P; Laudon, M; Ouyang, X; Tang, C; Tian, S; Yin, W; Zhou, S, 2013) |
| "Hyperhomocysteinemia was induced in female rats by administration of methionine during pregnancy at a dose of 1 g/kg body weight dissolved in drinking water." | 5.35 | Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats. ( Baydas, G; Koz, ST; Nedzvetsky, VS; Tuzcu, M, 2008) |
| "The current review aims to examine melatonin therapy for both sleep disturbances and cognitive function in dementia." | 4.91 | Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials. ( Chen, SD; Dammer, EB; Li, CB; Wang, G; Wang, LL; Xu, G; Xu, J, 2015) |
| "There is insufficient evidence to support the effectiveness of melatonin in managing the cognitive and non-cognitive sequelae of dementia." | 4.83 | Melatonin for cognitive impairment. ( Duncan, V; Forbes, DA; Jansen, SL; Morgan, DG, 2006) |
| "To assess if high morning plasma melatonin concentrations were associated with delirium." | 3.85 | Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. ( de Rooij, SE; Kema, IP; Scholtens, RM; van Faassen, M; van Kempen, MF; van Munster, BC, 2017) |
| "In this study, the relationship between the plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several intercellular interactions including inflammatory and immune responses, and early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined." | 3.81 | The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery. ( Akçalı, A; Ali Elçi, M; Deniz, H; Geyik, S; Hafız, E; Murat Geyik, A; Yiğiter, R, 2015) |
| "To study disturbances of sleep and circadian rhythms in patients with cardiovascular diseases taking into account the level of melatonin secretion and to optimize a complex approach to their treatment." | 3.81 | [Sleep disorders and circadian rhythms in diseases of the cardiovascular system]. ( Eneeva, MA; Kamchatnov, PR; Kostenko, EV; Petrova, LV, 2015) |
| "To study melatonin secretion and its correlations with poststroke cognitive, emotional impairment and sleep quality in the acute period of stroke and to assess treatment efficacy of melaxen." | 3.80 | [Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen]. ( Kulesh, AA; Shestakov, VV, 2014) |
| "The content of 6-sulfatoximelatonin in daily urine and butyrylcholinesterase in blood serum was determined in the acute stage of ischemic stroke in 25 and 40 men, respectively." | 3.78 | [Secretion of melatonin and serum cholinesterase activity as biological markers of cognitive disorders in the acute stage of ischemic stroke]. ( Kulesh, AA; Shestakov, VV, 2012) |
| "Fourteen middle-aged individuals diagnosed with schizophrenia underwent continuous wrist actimetry monitoring in real-life settings for 3 weeks, and collected saliva samples to determine the onset of endogenous melatonin secretion as a circadian phase marker." | 3.77 | Sleep-wake cycles and cognitive functioning in schizophrenia. ( Bromundt, V; Cajochen, C; Georgiev-Kill, A; Köster, M; Opwis, K; Stoppe, G; Wirz-Justice, A, 2011) |
| "In multiple sclerosis (MS), several neuroimmunomodulatory effectors are known, including melatonin." | 3.72 | The influence of immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis. ( Faustmann, PM; Haase, CG; Tinnefeld, M, 2004) |
| " This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies." | 2.53 | Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions. ( Fu, W; Liu, J; Wang, Y, 2016) |
| "Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases." | 2.50 | Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014) |
| "Delirium is a serious neuropsychiatric syndrome of acute onset that occurs in approximately one in five general hospital patients and is associated with serious adverse outcomes that include loss of adaptive function, persistent cognitive problems and increased mortality." | 2.49 | Delirium: a disturbance of circadian integrity? ( Adamis, D; Dunne, C; Fitzgerald, JM; Meagher, DJ; O'Regan, N; Timmons, S; Trzepacz, PT, 2013) |
| "Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are the most common central nervous system dysfunctions during the perioperative period." | 1.62 | Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction. ( Mu, S; Wu, A; Wu, Y, 2021) |
| "Melatonin pretreatment were conducted before anesthesia for 7 Days." | 1.43 | Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice. ( Chu, S; Cui, Y; Gu, X; Ma, Z; Qian, Y; Song, J; Xia, T, 2016) |
| "Among shift work disorder patients, insomnia is linked to functional and cognitive impairments." | 1.42 | Insomnia in shift work disorder relates to occupational and neurophysiological impairment. ( Belcher, R; Gumenyuk, V; Roth, T, 2015) |
| "Diisononyl phthalate (DINP) is a plasticizer that is frequently used as a substitute for other plasticizers whose use is prohibited in certain products." | 1.42 | Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. ( Bornehag, CG; Guo, J; Liu, C; Liu, X; Lu, Y; Ma, P; Nanberg, E; Wu, J; Wu, Y; Yan, B; Yang, X; Zhang, Y, 2015) |
| "Melatonin is a hormone with well-known chronobiotic and hypnotic effects." | 1.40 | Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014) |
| "Melatonin was effective in the memory facilitating effects only when administered in the afternoon." | 1.39 | A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease. ( He, P; Laudon, M; Ouyang, X; Tang, C; Tian, S; Yin, W; Zhou, S, 2013) |
| "Melatonin is an important modulator of nervous system functioning and important neural antioxidant." | 1.39 | Melatonin attenuates cognitive dysfunction and reduces neural oxidative stress induced by phosphamidon. ( Bhattacharya, SK; Chalawadi Hanumantappa, MK; Khanna, N; Mehta, AK; Rathor, N; Sharma, AK, 2013) |
| "Melatonin is an endogenous hormone with neuroprotective effects." | 1.39 | Melatonin attenuates isoflurane-induced acute memory impairments in aged rats. ( Chui, D; Guo, X; Li, Z; Liu, Y; Ni, C; Qian, M; Tang, Y; Tian, X; Zhou, Y, 2013) |
| "Melatonin (15 mg/kg) was administered to the rats via intraperitoneal injection." | 1.39 | Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. ( Liang, XY; Liu, FE; Zhang, HF; Zhang, HQ; Zhang, L; Zhang, T, 2013) |
| "Melatonin is a potent antioxidant known to reverse free-radical mediated injury in the brain." | 1.37 | Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats. ( Hartman, R; Lekic, T; Manaenko, A; Rolland, W; Tang, J; Virbel, K; Zhang, JH, 2011) |
| "Hyperhomocysteinemia was induced in female rats by administration of methionine during pregnancy at a dose of 1 g/kg body weight dissolved in drinking water." | 1.35 | Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats. ( Baydas, G; Koz, ST; Nedzvetsky, VS; Tuzcu, M, 2008) |
| " Performance testing and subjective evaluations occurred prior to dosing and following forced awakening at 15:00, 2 h after dosing." | 1.34 | Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep. ( Cardenas, R; Eddy, DR; Fischer, J; Hickey, PA; Storm, WF; Welch, CB, 2007) |
| "Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist." | 1.34 | Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study. ( Brusco, LI; Cardinali, DP; Furio, AM, 2007) |
| "Melatonin is an endogenously generated potent antioxidant." | 1.32 | Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats. ( Cheng, Y; Feng, Z; Zhang, JT, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (6.90) | 18.2507 |
| 2000's | 16 (27.59) | 29.6817 |
| 2010's | 35 (60.34) | 24.3611 |
| 2020's | 3 (5.17) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, S | 1 |
| Wu, Y | 3 |
| Wu, A | 2 |
| Kraiwattanapirom, N | 1 |
| Komlao, P | 1 |
| Harnpramukkul, A | 1 |
| Promyo, K | 1 |
| Ngampramuan, S | 1 |
| Chetsawang, B | 2 |
| Sumsuzzman, DM | 1 |
| Choi, J | 1 |
| Jin, Y | 1 |
| Hong, Y | 1 |
| Rajput, P | 1 |
| Jangra, A | 1 |
| Kwatra, M | 1 |
| Mishra, A | 1 |
| Lahkar, M | 1 |
| Scholtens, RM | 1 |
| van Munster, BC | 1 |
| van Faassen, M | 1 |
| van Kempen, MF | 1 |
| Kema, IP | 1 |
| de Rooij, SE | 1 |
| Gong, YH | 1 |
| Hua, N | 1 |
| Zang, X | 1 |
| Huang, T | 1 |
| He, L | 1 |
| Manousakis, JE | 1 |
| Scovelle, AJ | 1 |
| Rajaratnam, SMW | 1 |
| Naismith, SL | 1 |
| Anderson, C | 1 |
| Liu, Y | 1 |
| Ni, C | 1 |
| Tang, Y | 1 |
| Tian, X | 1 |
| Zhou, Y | 1 |
| Qian, M | 1 |
| Li, Z | 1 |
| Chui, D | 1 |
| Guo, X | 1 |
| He, P | 1 |
| Ouyang, X | 1 |
| Zhou, S | 1 |
| Yin, W | 1 |
| Tang, C | 1 |
| Laudon, M | 1 |
| Tian, S | 1 |
| Fitzgerald, JM | 1 |
| Adamis, D | 1 |
| Trzepacz, PT | 1 |
| O'Regan, N | 1 |
| Timmons, S | 1 |
| Dunne, C | 1 |
| Meagher, DJ | 1 |
| Zhang, L | 1 |
| Zhang, HQ | 1 |
| Liang, XY | 1 |
| Zhang, HF | 1 |
| Zhang, T | 1 |
| Liu, FE | 1 |
| Sarlak, G | 1 |
| Jenwitheesuk, A | 1 |
| Govitrapong, P | 1 |
| Miano, S | 1 |
| Peraita-Adrados, R | 1 |
| O'Neill, B | 1 |
| Gardani, M | 1 |
| Findlay, G | 1 |
| Whyte, T | 1 |
| Cullen, T | 1 |
| Wang, J | 1 |
| Yue, Y | 1 |
| Mehta, KD | 1 |
| Mehta, AK | 2 |
| Halder, S | 1 |
| Khanna, N | 2 |
| Tripathi, AK | 1 |
| Sharma, KK | 1 |
| Kulesh, AA | 2 |
| Shestakov, VV | 2 |
| Burkhalter, H | 1 |
| Wirz-Justice, A | 2 |
| Denhaerynck, K | 1 |
| Fehr, T | 1 |
| Steiger, J | 1 |
| Venzin, RM | 1 |
| Cajochen, C | 2 |
| Weaver, TE | 1 |
| De Geest, S | 1 |
| Hansen, MV | 1 |
| Xu, J | 1 |
| Wang, LL | 1 |
| Dammer, EB | 1 |
| Li, CB | 1 |
| Xu, G | 1 |
| Chen, SD | 1 |
| Wang, G | 1 |
| Belcher, R | 1 |
| Gumenyuk, V | 1 |
| Roth, T | 1 |
| Wang, Y | 1 |
| Fu, W | 1 |
| Liu, J | 1 |
| Lucke-Wold, BP | 1 |
| Smith, KE | 1 |
| Nguyen, L | 1 |
| Turner, RC | 1 |
| Logsdon, AF | 1 |
| Jackson, GJ | 1 |
| Huber, JD | 1 |
| Rosen, CL | 1 |
| Miller, DB | 1 |
| Geyik, S | 1 |
| Yiğiter, R | 1 |
| Akçalı, A | 1 |
| Deniz, H | 1 |
| Murat Geyik, A | 1 |
| Ali Elçi, M | 1 |
| Hafız, E | 1 |
| Targum, SD | 1 |
| Wedel, PC | 1 |
| Fava, M | 1 |
| Kostenko, EV | 1 |
| Petrova, LV | 1 |
| Eneeva, MA | 1 |
| Kamchatnov, PR | 1 |
| Ma, P | 1 |
| Liu, X | 1 |
| Wu, J | 1 |
| Yan, B | 1 |
| Zhang, Y | 1 |
| Lu, Y | 1 |
| Liu, C | 1 |
| Guo, J | 1 |
| Nanberg, E | 1 |
| Bornehag, CG | 1 |
| Yang, X | 2 |
| Xia, T | 1 |
| Cui, Y | 1 |
| Chu, S | 1 |
| Song, J | 1 |
| Qian, Y | 1 |
| Ma, Z | 1 |
| Gu, X | 1 |
| Mei, Y | 1 |
| Duan, C | 1 |
| Li, X | 1 |
| Zhao, Y | 1 |
| Cao, F | 1 |
| Shang, S | 1 |
| Ding, S | 1 |
| Yue, X | 1 |
| Gao, G | 1 |
| Yang, H | 1 |
| Shen, L | 1 |
| Feng, X | 1 |
| Jia, J | 1 |
| Tong, Z | 1 |
| Olcese, JM | 1 |
| Cao, C | 1 |
| Mori, T | 1 |
| Mamcarz, MB | 1 |
| Maxwell, A | 1 |
| Runfeldt, MJ | 1 |
| Wang, L | 1 |
| Zhang, C | 1 |
| Lin, X | 1 |
| Zhang, G | 2 |
| Arendash, GW | 1 |
| Turner, PL | 1 |
| Van Someren, EJ | 2 |
| Mainster, MA | 1 |
| Arushanian, EB | 1 |
| Gögenur, I | 1 |
| Bromundt, V | 1 |
| Köster, M | 1 |
| Georgiev-Kill, A | 1 |
| Opwis, K | 1 |
| Stoppe, G | 1 |
| Ferber, SG | 1 |
| Als, H | 1 |
| McAnulty, G | 1 |
| Peretz, H | 1 |
| Zisapel, N | 1 |
| Lekic, T | 1 |
| Manaenko, A | 1 |
| Rolland, W | 1 |
| Virbel, K | 1 |
| Hartman, R | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Sharma, AK | 1 |
| Rathor, N | 1 |
| Chalawadi Hanumantappa, MK | 1 |
| Bhattacharya, SK | 1 |
| Vogel, M | 1 |
| Braungardt, T | 1 |
| Meyer, W | 1 |
| Schneider, W | 1 |
| Alpini, D | 1 |
| Cesarani, A | 1 |
| Fraschini, F | 1 |
| Kohen-Raz, R | 1 |
| Capobianco, S | 1 |
| Cornelio, F | 1 |
| Feng, Z | 1 |
| Cheng, Y | 1 |
| Zhang, JT | 1 |
| Haase, CG | 1 |
| Tinnefeld, M | 1 |
| Faustmann, PM | 1 |
| Yun, AJ | 1 |
| Bazar, KA | 1 |
| Lee, PY | 1 |
| Serrano, C | 1 |
| García-Borreguero, D | 1 |
| Crowley, SJ | 1 |
| Lee, C | 1 |
| Tseng, CY | 1 |
| Fogg, LF | 1 |
| Eastman, CI | 1 |
| Jansen, SL | 1 |
| Forbes, DA | 1 |
| Duncan, V | 1 |
| Morgan, DG | 1 |
| Chen, F | 1 |
| Lemonnier, E | 1 |
| Lazartigues, A | 1 |
| Planche, P | 1 |
| Storm, WF | 1 |
| Eddy, DR | 1 |
| Welch, CB | 1 |
| Hickey, PA | 1 |
| Fischer, J | 1 |
| Cardenas, R | 1 |
| Van der Heijden, KB | 1 |
| Smits, MG | 1 |
| Ridderinkhof, KR | 1 |
| Gunning, WB | 1 |
| Shen, Y | 1 |
| Liu, L | 1 |
| Xu, S | 1 |
| Furio, AM | 1 |
| Brusco, LI | 1 |
| Cardinali, DP | 1 |
| Luo, AL | 2 |
| Yin, YQ | 1 |
| Guo, XY | 1 |
| Li, LH | 1 |
| Huang, YG | 1 |
| Baydas, G | 1 |
| Koz, ST | 1 |
| Tuzcu, M | 1 |
| Nedzvetsky, VS | 1 |
| Sandyk, R | 2 |
| Sternon, J | 1 |
| Jean-Louis, G | 1 |
| von Gizycki, H | 1 |
| Zizi, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Daily Light Intervention in Renal Transplant Recipients Having a Sleep-Wake Dysregulation[NCT01256983] | Early Phase 1 | 30 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054] | 50 participants (Anticipated) | Observational | 2017-03-15 | Enrolling by invitation | |||
| The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599] | Phase 2 | 86 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702] | 35 participants (Anticipated) | Observational | 2017-03-29 | Enrolling by invitation | |||
| A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia[NCT03066518] | Phase 4 | 40 participants (Actual) | Interventional | 2016-01-15 | Completed | ||
| Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609] | 60 participants (Anticipated) | Interventional | 2023-12-08 | Recruiting | |||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The mean bedtime assessed by actimetry of each 3 week period (day 21, 42, 63 ) was used as outcome to be compared with the control group.~Bedtime is expressed in time (hours and minutes)" (NCT01256983)
Timeframe: Mean Bedtimes over 21 days for each period
| Intervention | Hours (Mean) | |
|---|---|---|
| Getup time | Bedtime | |
| Light Box | 7.44 | 22.98 |
| No Intervention | 7.24 | 22.48 |
Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days
| Intervention | days (Median) |
|---|---|
| Morphine | 7 |
| Levobupivacaine | 7 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | mg/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 57.8 | 98.1 | 95 | 54.6 |
| Morphine | 57.2 | 106.2 | 118.5 | 66.9 |
"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery
| Intervention | score on a scale (Median) | |||||
|---|---|---|---|---|---|---|
| Before surgery | 24 h after surgery | 48 h after surgery | 72 h after surgery | 96 h after surgery | 120 h after surgery | |
| Levobupivacaine | 22 | 22 | 21 | 21 | 21 | 22 |
| Morphine | 21 | 20 | 20 | 20 | 20 | 20 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | g/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 4.5 | 4.7 | 5.2 | 5 |
| Morphine | 5.5 | 5.3 | 5.7 | 5.4 |
"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge
| Intervention | score on a scale (Median) | ||||||
|---|---|---|---|---|---|---|---|
| 3,6,9,12,15,18,21 and 24h after surgery | 27,30,33,36,39,42,45 and 48h after surgery | 51,54,57,60,63,66,69 and 72h after surgery | 4. postoperative day (every 8 hours) | 5. postoperative day (every 8 hours) | 6. postoperative day (every 8 hours) | Day of discharge | |
| Levobupivacaine | 0.6 | 0.5 | 0.5 | 0.3 | 0 | 0 | 0 |
| Morphine | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.3 | 1 |
Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery
| Intervention | pg/ml (Median) | ||
|---|---|---|---|
| Before surgery | 24h after surgery | 72h after surgery | |
| Levobupivacaine | 26.6 | 97.7 | 30.5 |
| Morphine | 27.2 | 104 | 50 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
14 reviews available for melatonin and Cognition Disorders
| Article | Year |
|---|---|
Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Alzheimer Disease; Cognition Disorders; Humans; Melatonin; Randomized Controlled Trials as To | 2021 |
Delirium: a disturbance of circadian integrity?
Topics: Ataxia; Chronobiology Disorders; Cognition Disorders; Delirium; Humans; Melatonin; Models, Biologica | 2013 |
Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration.
Topics: Aged; Aging; Animals; Apoptosis; Cognition Disorders; Humans; Melatonin; Nerve Degeneration; Neural | 2013 |
Pediatric insomnia: clinical, diagnosis, and treatment.
Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di | 2014 |
Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.
Topics: Alzheimer Disease; Central Nervous System Depressants; Cognition; Cognition Disorders; Dementia; Dem | 2015 |
Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions.
Topics: Adult; Antioxidants; Brain; Cerebral Palsy; Child; Cognition Disorders; Depression; Developmental Di | 2016 |
Sleep disruption and the sequelae associated with traumatic brain injury.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain Injuries; Cogniti | 2015 |
[A hormonal drug melatonin in the treatment of cognitive function disorders in parkinsonism].
Topics: Cognition Disorders; Corpus Striatum; Dementia; Humans; Melatonin; Neuroprotective Agents; Nootropic | 2010 |
Postoperative circadian disturbances.
Topics: Body Temperature Regulation; Central Nervous System Depressants; Chronobiology Disorders; Cognition | 2010 |
The effects of shift work on physical and mental health.
Topics: Adaptation, Physiological; Adaptation, Psychological; Cardiovascular Diseases; Circadian Rhythm; Cog | 2012 |
Fluctuations in cognition and alertness in Parkinson's disease and dementia.
Topics: Awareness; Central Nervous System Stimulants; Cholinesterase Inhibitors; Cognition Disorders; Dement | 2004 |
Melatonin for cognitive impairment.
Topics: Antioxidants; Cognition Disorders; Dementia; Humans; Melatonin; Randomized Controlled Trials as Topi | 2006 |
Weak electromagnetic fields reverse visuospatial hemi-inattention in Parkinson's disease.
Topics: Aged; Brain; Cognition Disorders; Electromagnetic Phenomena; Functional Laterality; Humans; Male; Me | 1995 |
Magnetic fields in the therapy of parkinsonism.
Topics: Aged; Brain; Brain Diseases; Cognition Disorders; Dopamine; Electromagnetic Fields; Female; Function | 1992 |
4 trials available for melatonin and Cognition Disorders
| Article | Year |
|---|---|
The effect of bright light therapy on sleep and circadian rhythms in renal transplant recipients: a pilot randomized, multicentre wait-list controlled trial.
Topics: Adult; Body Mass Index; Circadian Rhythm; Cognition; Cognition Disorders; Female; Humans; Kidney Fai | 2015 |
Changes in cognitive symptoms after a buspirone-melatonin combination treatment for Major Depressive Disorder.
Topics: Acute Disease; Antioxidants; Buspirone; Cognition Disorders; Depressive Disorder, Major; Double-Blin | 2015 |
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Chronic Disease; Cir | 2007 |
Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment.
Topics: Affect; Aged; Circadian Rhythm; Cognition; Cognition Disorders; Cross-Over Studies; Double-Blind Met | 1998 |
40 other studies available for melatonin and Cognition Disorders
| Article | Year |
|---|---|
Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction.
Topics: Cognition Disorders; Delirium; Humans; Incidence; Melatonin; Postoperative Cognitive Complications | 2021 |
The neuroprotective role of melatonin against methamphetamine toxicity-induced neurotransmission dysregulation and cognitive deficits in rats.
Topics: Animals; Attention; Blotting, Western; Cognition; Cognition Disorders; Corpus Striatum; Hippocampus; | 2021 |
Alcohol aggravates stress-induced cognitive deficits and hippocampal neurotoxicity: Protective effect of melatonin.
Topics: Acetylcholinesterase; Alcohol Drinking; Animals; Cognition; Cognition Disorders; Ethanol; Gene Expre | 2017 |
Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Circadian Rhythm; Cognition Disorders; Delirium; Fe | 2017 |
Melatonin ameliorates Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Cognition Disorders; | 2018 |
Advanced Circadian Timing and Sleep Fragmentation Differentially Impact on Memory Complaint Subtype in Subjective Cognitive Decline.
Topics: Aged; Chronobiology Disorders; Cognition Disorders; Female; Humans; Male; Melatonin; Memory Disorder | 2018 |
Melatonin attenuates isoflurane-induced acute memory impairments in aged rats.
Topics: Animals; Cognition Disorders; Hippocampus; Isoflurane; Male; Maze Learning; Melatonin; Memory; Memor | 2013 |
A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Cognition Disorders; Indoles; M | 2013 |
Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII.
Topics: Animals; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protei | 2013 |
Challenging behaviour and sleep cycle disorder following brain injury: a preliminary response to agomelatine treatment.
Topics: Acetamides; Brain Injuries; Cognition Disorders; Humans; Hypnotics and Sedatives; Male; Melatonin; M | 2014 |
Do fluctuations in endogenous melatonin levels predict the occurrence of postoperative cognitive dysfunction (POCD)?
Topics: Aged; Aged, 80 and over; China; Cognition Disorders; Female; Humans; Incidence; Male; Melatonin; Mid | 2014 |
Protective effect of melatonin on propoxur-induced impairment of memory and oxidative stress in rats.
Topics: Animals; Brain; Catalase; Cognition; Cognition Disorders; Glutathione; Male; Malondialdehyde; Melato | 2014 |
[Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen].
Topics: Adult; Aged; Anxiety; Cognition; Cognition Disorders; Emotions; Female; Humans; Male; Melatonin; Mid | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Chronobiology, cognitive function and depressive symptoms in surgical patients.
Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep | 2014 |
Insomnia in shift work disorder relates to occupational and neurophysiological impairment.
Topics: Adult; Brain; Cognition Disorders; Efficiency; Evoked Potentials; Female; Humans; Male; Melatonin; S | 2015 |
The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery.
Topics: Circadian Rhythm; Cognition Disorders; Coronary Artery Bypass; Female; Humans; Inflammation; Interce | 2015 |
[Sleep disorders and circadian rhythms in diseases of the cardiovascular system].
Topics: Aged; Cardiovascular Diseases; Circadian Rhythm; Cognition Disorders; Female; Humans; Male; Melatoni | 2015 |
Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin.
Topics: Animals; Anxiety; Brain; Caspase 3; Cognition Disorders; Drug Evaluation, Preclinical; Glial Fibrill | 2015 |
Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice.
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Isoflurane; Male; Melaton | 2016 |
Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.
Topics: Adult; Animals; Brain; Cognition; Cognition Disorders; Formaldehyde; Hippocampus; Humans; Male; Mela | 2016 |
Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Ca | 2009 |
The role of environmental light in sleep and health: effects of ocular aging and cataract surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cataract Extraction; Child; Circadian | 2010 |
Sleep-wake cycles and cognitive functioning in schizophrenia.
Topics: Actigraphy; Adult; Circadian Rhythm; Cognition Disorders; Female; Humans; Male; Melatonin; Middle Ag | 2011 |
Melatonin and mental capacities in newborn infants.
Topics: Analysis of Variance; Autonomic Nervous System; Child Development; Cognition Disorders; Developmenta | 2011 |
Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Atrophy; Cerebral Cortex; Cognition D | 2011 |
Melatonin attenuates cognitive dysfunction and reduces neural oxidative stress induced by phosphamidon.
Topics: Animals; Brain; Cognition; Cognition Disorders; Drug Interactions; Male; Malondialdehyde; Melatonin; | 2013 |
[Secretion of melatonin and serum cholinesterase activity as biological markers of cognitive disorders in the acute stage of ischemic stroke].
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Butyrylcholinesterase; Cognition Disorders; Humans; Male | 2012 |
Aging and vestibular system: specific tests and role of melatonin in cognitive involvement.
Topics: Accidental Falls; Aged; Aged, 80 and over; Aging; Cerebellum; Chronobiology Disorders; Cognition Dis | 2004 |
Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats.
Topics: Alzheimer Disease; Animals; Apoptosis; Choline O-Acetyltransferase; Cognition Disorders; Disease Mod | 2004 |
The influence of immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis.
Topics: Adult; Cognition Disorders; Depressive Disorder; Disability Evaluation; Evoked Potentials, Visual; F | 2004 |
Pineal attrition, loss of cognitive plasticity, and onset of puberty during the teen years: is it a modern maladaptation exposed by evolutionary displacement?
Topics: Adolescent; Adult; Aging; Cognition; Cognition Disorders; Gene Expression Regulation, Developmental; | 2004 |
Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.
Topics: Adolescent; Adult; Arousal; Body Temperature; Circadian Rhythm; Cognition Disorders; Disorders of Ex | 2004 |
Sleep problems and information processing, a "disconnection effect" in autism?
Topics: Autistic Disorder; Brain; Cognition; Cognition Disorders; Humans; Information Storage and Retrieval; | 2006 |
Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep.
Topics: Adjuvants, Immunologic; Adult; Circadian Rhythm; Clinical Trials as Topic; Cognition; Cognition Diso | 2007 |
Suppressive effects of melatonin on amyloid-beta-induced glial activation in rat hippocampus.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Complement C1q; Hippocampus; Humans; Interleuki | 2007 |
Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Central Nervous System Depressants; Cognition Disorders; | 2007 |
Circadian rhythm: a new clue for neuropsychological dysfunction after cardiac surgery.
Topics: Cardiac Surgical Procedures; Circadian Rhythm; Cognition Disorders; Humans; Hydrocortisone; Melatoni | 2007 |
Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting.
Topics: Cardiopulmonary Bypass; Circadian Rhythm; Cognition Disorders; Coronary Artery Bypass; Humans; Hydro | 2007 |
Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cognition Disorders; Female; Hyperhomocysteinemia; Male | 2008 |
[Melatonin, methadone, tacrine, vitamin K antagonists and low-molecular-weight heparin].
Topics: Aged; Anticoagulants; Cholinesterase Inhibitors; Circadian Rhythm; Cognition Disorders; Heroin Depen | 1996 |