melatonin has been researched along with Chronic Disease in 96 studies
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of short- and long-term administration of melatonin on central brain-derived neurotrophic factor (BDNF) levels in rats with acute and chronic inflammatory pain." | 9.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity." | 9.14 | Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. ( Braam, W; Curfs, LM; Didden, R; Korzilius, H; Maas, AP; Smits, MG, 2010) |
| "The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study." | 9.07 | The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. ( Brown, GM; Cleghorn, JM; MacFarlane, JG; Streiner, DL, 1991) |
| " Since there is a direct relationship between chronic inflammation and many emerging disorders like cancer, oral diseases, kidney diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of this review is to describe the use and role of melatonin, a hormone secreted by the pineal gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant." | 8.91 | Evaluating the Oxidative Stress in Inflammation: Role of Melatonin. ( Calpena, AC; Clares, B; Sánchez, A, 2015) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 7.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| "Preclinical studies have shown that melatonin exercised antidepressant-like and anxiolyticlike effects in animal models of anxiety." | 7.83 | Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2016) |
| "Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function." | 7.83 | Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016) |
| "To study the effect of melatonin, a potent antioxidant both in vitro and in vivo, on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease (CLD)." | 7.75 | [Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease]. ( Fu, JH; Pan, L; Xu, W; Xue, XD, 2009) |
| "The current study was conducted to investigate the relationship between melatonin and chronic anovulation." | 7.72 | Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome. ( Baracat, EC; Prata Lima, MF; Simões, MJ, 2004) |
| "The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes." | 7.67 | Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986) |
| "Melatonin treatment improves some aspects of chronic sleep disturbance in individuals with ID." | 6.73 | Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. ( Braam, W; Curfs, L; Didden, R; Smits, M, 2008) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 6.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 5.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "Melatonin treatment significantly mitigated the increased expression of NADPH oxidase, pro-inflammatory mediators, and adhesion molecules." | 5.39 | Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Kravtsov, GM; Lau, CF; Poon, AM; Tipoe, GL, 2013) |
| "Chagas' disease is a severe health problem in Latin America, causing approximately 50 000 deaths a year, with approximately 18 million infected people." | 5.37 | Melatonin in Chagas' disease. Possible therapeutic value. ( Alvarez, CB; Cardinali, DP, 2011) |
| "Melatonin (MT) is an ubiquitous molecule, representing one of the phylogenetically oldest signaling mechanisms." | 5.35 | Tryptophan free diet delays healing of chronic gastric ulcers in rat. ( Brzozowski, T; Burnat, G; Konturek, PC; Konturek, SJ; Zopf, Y, 2008) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 5.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "Melatonin was estimated by RIA in samples taken at 24." | 5.26 | Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight. ( Arendt, J; Crow, TJ; Ferrier, IN; Johnstone, EC, 1982) |
| "To evaluate the effect of short- and long-term administration of melatonin on central brain-derived neurotrophic factor (BDNF) levels in rats with acute and chronic inflammatory pain." | 5.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication." | 5.19 | Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2014) |
| "Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity." | 5.14 | Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. ( Braam, W; Curfs, LM; Didden, R; Korzilius, H; Maas, AP; Smits, MG, 2010) |
| "To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia." | 5.14 | Safety and subjective sleep effects of ramelteon administration in adults and older adults with chronic primary insomnia: a 1-year, open-label study. ( Richardson, GS; Wang-Weigand, S; Zammit, G; Zhang, J, 2009) |
| "Using a double-blind, placebo-controlled, crossover study, we evaluated the efficacy of 10 mg/d of melatonin for 6 weeks in 22 patients with schizophrenia and TD." | 5.09 | Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. ( Barak, Y; Elizur, A; Laudon, M; Shalman, I; Shamir, E; Tarrasch, R; Weizman, R; Zisapel, N, 2001) |
| "The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study." | 5.07 | The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. ( Brown, GM; Cleghorn, JM; MacFarlane, JG; Streiner, DL, 1991) |
| " Since there is a direct relationship between chronic inflammation and many emerging disorders like cancer, oral diseases, kidney diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of this review is to describe the use and role of melatonin, a hormone secreted by the pineal gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant." | 4.91 | Evaluating the Oxidative Stress in Inflammation: Role of Melatonin. ( Calpena, AC; Clares, B; Sánchez, A, 2015) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
| "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats." | 3.91 | Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2019) |
| "Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function." | 3.83 | Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016) |
| "Preclinical studies have shown that melatonin exercised antidepressant-like and anxiolyticlike effects in animal models of anxiety." | 3.83 | Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2016) |
| " Melatonin has protective effects against cerebral ischemia/reperfusion injury." | 3.75 | Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats. ( Barut, F; Ozacmak, HS; Ozacmak, VH, 2009) |
| "Previous study has shown that administration of melatonin into the anterior cingulate cortex contralateral to peripheral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats." | 3.75 | A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. ( Chou, CW; Hernstadt, H; Lim, G; Ma, Y; Mao, J; Rusanescu, G; Sung, B; Tian, Y; Wang, S; Zhang, L, 2009) |
| "To study the effect of melatonin, a potent antioxidant both in vitro and in vivo, on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease (CLD)." | 3.75 | [Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease]. ( Fu, JH; Pan, L; Xu, W; Xue, XD, 2009) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| "The current study was conducted to investigate the relationship between melatonin and chronic anovulation." | 3.72 | Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome. ( Baracat, EC; Prata Lima, MF; Simões, MJ, 2004) |
| "Clinicoendoscopic morphological and morphofunctional studies in 50 patients with chronic cholecystitis and 50 patients with chronic biliary pancreatitis have demonstrated that morphometric analysis of the antral stomach endocrine cells secreting melatonin, neurotensin and somatostatin can be used in addition to standard laboratory and device methods for differentiation chronic biliary pancreatitis with biliary pathology." | 3.71 | [Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis]. ( Balashov, VI; Kvetnoĭ, IM; Lipatova, TE; Osadchuk, MA, 2001) |
| " One measurable variable of the ageing process may be melatonin, known to decrease with age and to be lower in patients with coronary heart disease than in normal individuals." | 3.69 | Premature ageing: the link between psychosocial risk factors and disease. ( Nilsson, PM, 1996) |
| "A haloperidol-treated patient with chronic schizophrenia had a near-arrhythmic circadian rest-activity cycle, whereas rhythms of 6-sulphatoxy-melatonin and core body temperature were of normal amplitude and phase-advanced." | 3.69 | A schizophrenic patient with an arrhythmic circadian rest-activity cycle. ( Cajochen, C; Nussbaum, P; Wirz-Justice, A, 1997) |
| "The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes." | 3.67 | Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986) |
| "Melatonin treatment improves some aspects of chronic sleep disturbance in individuals with ID." | 2.73 | Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. ( Braam, W; Curfs, L; Didden, R; Smits, M, 2008) |
| " There were no differences in the number or type of adverse events between any active treatment and placebo group." | 2.72 | An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia. ( Erman, M; Sainati, S; Seiden, D; Zammit, G; Zhang, J, 2006) |
| "Melatonin was well tolerated by the newborns." | 2.71 | Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin. ( Amodio, A; Barberi, I; Buonocore, G; Cordaro, V; Cuzzocrea, E; Gitto, E; Reiter, RJ; Romeo, C; Sabatino, G; Trimarchi, G, 2004) |
| "Melatonin treatment also significantly advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes." | 2.71 | Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. ( Coenen, AM; Kerkhof, GA; Meijer, AM; Smits, MG; van der Heijden, K; van Stel, HF, 2003) |
| "The periodicity of cluster headache suggests involvement of the suprachiasmatic nucleus of the hypothalamus, the biological clock." | 2.70 | Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. ( Aubé, M; Dobson, CF; Hamel, E; Magnoux, E; Pringsheim, T, 2002) |
| "Melatonin has been shown as a specific antioxidant reducing oxidative damage in both lipid and aqueous cell environments." | 2.47 | New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin. ( García-Mauriño, S; Illanes, M; Motilva, V; Talero, E, 2011) |
| "Benign cysts of the gland have been related to headache, although the mechanism of production of this assumed clinical manifestation has not been clearly determined, due to the lack of large prospective studies." | 2.46 | Some questions provoked by a chronic headache (with mixed migraine and cluster headache features) in a woman with a pineal cyst. Answers from a literature review. ( Jiménez-Martínez, MC; Molina-Martínez, FJ; Vives-Pastor, B, 2010) |
| "Melatonin is a methoxyindole synthesized and secreted principally by the pineal gland at night under normal environmental conditions." | 2.43 | The basic physiology and pathophysiology of melatonin. ( Brun, J; Chazot, G; Claustrat, B, 2005) |
| "Pain is a multi-dimensional process involving the physical, emotional and perceptual integration of noxious information." | 2.42 | Pain in the brain: are hormones to blame? ( Blackburn-Munro, G; Blackburn-Munro, R, 2003) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 2.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 1.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "Melatonin, which promotes the metabolism of many reactive oxygen species (ROS), has antioxidant and neuroprotective properties." | 1.43 | Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation. ( Alhashimi, FH; Alzoubi, KH; Bani Salama, FM; Khabour, OF; Mayyas, FA; Mhaidat, NM, 2016) |
| "Melatonin treatment significantly mitigated the increased expression of NADPH oxidase, pro-inflammatory mediators, and adhesion molecules." | 1.39 | Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Kravtsov, GM; Lau, CF; Poon, AM; Tipoe, GL, 2013) |
| "Melatonin was dispensed in the highest annual amount of all hypnotic drugs; accounting up to a median of 360 defined daily doses in 9-13 year old boys." | 1.38 | Hypnotic drug use among 0-17 year olds during 2004-2011: a nationwide prescription database study. ( Bratlid, T; Furu, K; Handal, M; Hartz, I; Skurtveit, S, 2012) |
| "The etiology of Chagas' disease, caused by a protozoan parasite Trypanosoma cruzi, has been the focus of considerable discussion, although chronic phase still remains not fully understood." | 1.37 | Melatonin and zinc treatment: distinctive modulation of cytokine production in chronic experimental Trypanosoma cruzi infection. ( Abrahão, AA; Brazão, V; Caetano, LC; Del Vecchio Filipin, M; do Prado, JC; Santello, FH; Toldo, MP, 2011) |
| "Chagas' disease is a severe health problem in Latin America, causing approximately 50 000 deaths a year, with approximately 18 million infected people." | 1.37 | Melatonin in Chagas' disease. Possible therapeutic value. ( Alvarez, CB; Cardinali, DP, 2011) |
| "CCI significantly caused thermal hyperalgesia, cold allodynia and oxidative damage." | 1.37 | Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats. ( Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S, 2011) |
| "Melatonin (MT) is an ubiquitous molecule, representing one of the phylogenetically oldest signaling mechanisms." | 1.35 | Tryptophan free diet delays healing of chronic gastric ulcers in rat. ( Brzozowski, T; Burnat, G; Konturek, PC; Konturek, SJ; Zopf, Y, 2008) |
| "In melatonin and vitamin C-treated groups, eNOS immunoreactivity was diffuse and the intensity of reaction was (+++) in subepicardial region." | 1.35 | Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. ( Akkuş, D; Narin, F; Ozdamar, S; Sönmez, MF, 2009) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 1.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
| "Melatonin treatment improved all scales except the scale "role due to emotional problems." | 1.31 | Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. ( Coenen, AM; Kerkhof, GA; Laurant, MW; Nagtegaal, JE; Smits, MG; van der Meer, YG, 2000) |
| "Melatonin is a promising treatment alternative for serious sleep problems in blind children." | 1.31 | [Melatonin treatment of a blind child with serious sleep disorders]. ( Loge, JH; Ramstad, K, 2002) |
| " We found that the antioxidant melatonin (500 microg/kg bw) prevents cell death as well as the damage induced by chronic administration of MPTP measured as number of nigral cells, tyrosine hydroxylase levels, and several ultra-structural features." | 1.31 | Protective effect of melatonin in a chronic experimental model of Parkinson's disease. ( Antolín, I; del Brío, Mde L; Herrera, F; Martín, V; Mayo, JC; Rodríguez, C; Sainz, RM, 2002) |
| "Chronic migraine (CM), previously called transformed migraine, is a frequent headache disorder that affects 2%-3% of the general population." | 1.31 | Hypothalamic involvement in chronic migraine. ( Abucham, J; Cipolla-Neto, J; Peres, MF; Sanchez del Rio, M; Seabra, ML; Silberstein, SD; Tufik, S; Zukerman, E, 2001) |
| "Melatonin was estimated by RIA in samples taken at 24." | 1.26 | Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight. ( Arendt, J; Crow, TJ; Ferrier, IN; Johnstone, EC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.21) | 18.7374 |
| 1990's | 15 (15.63) | 18.2507 |
| 2000's | 36 (37.50) | 29.6817 |
| 2010's | 34 (35.42) | 24.3611 |
| 2020's | 6 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Wei, M | 1 |
| Sun, N | 1 |
| Wang, H | 4 |
| Fan, H | 1 |
| Can, A | 1 |
| Tuzer, OC | 1 |
| Petrova, A | 1 |
| Kondratiuk, V | 1 |
| Karpenko, O | 1 |
| Ostashevska, T | 1 |
| Krasiuk, E | 1 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 1 |
| Zhang, J | 3 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Wang, J | 7 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Li, Y | 6 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 2 |
| Cheng, J | 2 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Chen, K | 2 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 2 |
| Chen, Y | 4 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Liu, C | 3 |
| Lin, Y | 1 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 1 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Huang, W | 1 |
| Li, T | 1 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Yang, Y | 3 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 2 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
| Ge, JB | 1 |
| Milheiro, SA | 1 |
| Gonçalves, J | 1 |
| Lopes, RMRM | 1 |
| Madureira, M | 1 |
| Lobo, L | 1 |
| Lopes, A | 1 |
| Nogueira, F | 1 |
| Fontinha, D | 1 |
| Prudêncio, M | 1 |
| M Piedade, MF | 1 |
| Pinto, SN | 1 |
| Florindo, PR | 1 |
| Moreira, R | 1 |
| Castillo-Lora, J | 1 |
| Delley, MF | 1 |
| Laga, SM | 1 |
| Mayer, JM | 1 |
| Sutjarit, N | 1 |
| Thongon, N | 1 |
| Weerachayaphorn, J | 1 |
| Piyachaturawat, P | 1 |
| Suksamrarn, A | 1 |
| Suksen, K | 1 |
| Papachristou, DJ | 1 |
| Blair, HC | 1 |
| Hu, Y | 1 |
| Shen, P | 1 |
| Zeng, N | 1 |
| Wang, L | 3 |
| Yan, D | 1 |
| Cui, L | 1 |
| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 2 |
| Ye, W | 1 |
| Guo, P | 1 |
| Rahimi, S | 1 |
| Singh, MP | 1 |
| Gupta, J | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Shoji, Y | 1 |
| Fujitaka, Y | 1 |
| Shimoda, K | 1 |
| Matsumoto, KI | 1 |
| Fukuhara, K | 1 |
| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
| Berry, JD | 1 |
| Bedlack, R | 1 |
| Mathews, D | 1 |
| Agnese, W | 1 |
| Apple, S | 1 |
| Meloncelli, S | 1 |
| Divizia, M | 1 |
| Germani, G | 1 |
| Adefegha, SA | 1 |
| Bottari, NB | 1 |
| Leal, DB | 1 |
| de Andrade, CM | 1 |
| Schetinger, MR | 1 |
| Martínez-Velasco, A | 1 |
| Perez-Ortiz, AC | 1 |
| Antonio-Aguirre, B | 1 |
| Martínez-Villaseñor, L | 1 |
| Lira-Romero, E | 1 |
| Palacio-Pastrana, C | 1 |
| Zenteno, JC | 1 |
| Ramirez, I | 1 |
| Zepeda-Palacio, C | 1 |
| Mendoza-Velásquez, C | 1 |
| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps[NCT05095961] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-03-31 | Withdrawn (stopped due to Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.) | ||
| A Phase 3, Open-label, Fixed-dose Study to Determine the Safety of Long-term Administration of TAK-375 in Subjects With Chronic Insomnia[NCT00671086] | Phase 3 | 1,213 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504] | Phase 4 | 25 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | g (Mean) |
|---|---|
| Ramelteon | 3934.86 |
| Placebo (Sugar Pill) | 5120.92 |
A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | HOMA score (Mean) |
|---|---|
| Ramelteon | 2.4 |
| Placebo (Sugar Pill) | 2.36 |
A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | cm (Mean) |
|---|---|
| Ramelteon | 106.09 |
| Placebo (Sugar Pill) | 108.37 |
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
18 reviews available for melatonin and Chronic Disease
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Chronic Disea | 2021 |
Sleep and liver disease: a bidirectional relationship.
Topics: Body Temperature Regulation; Case-Control Studies; Chronic Disease; Cost of Illness; Disease Progres | 2021 |
Anti-inflammatory effects of Melatonin: A mechanistic review.
Topics: Animals; Anti-Inflammatory Agents; Cardiovascular System; Chronic Disease; Clinical Trials as Topic; | 2019 |
Treatment strategies for complex behavioral insomnia in children with neurodevelopmental disorders.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2013 |
Evaluating the Oxidative Stress in Inflammation: Role of Melatonin.
Topics: Animals; Chronic Disease; Humans; Inflammation; Melatonin; Neoplasms; Oral Health; Oxidative Stress | 2015 |
Some questions provoked by a chronic headache (with mixed migraine and cluster headache features) in a woman with a pineal cyst. Answers from a literature review.
Topics: Chronic Disease; Cluster Headache; Cysts; Female; Humans; Melatonin; Middle Aged; Migraine Disorders | 2010 |
New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin.
Topics: Animals; Autophagy; Chronic Disease; Colonic Neoplasms; Humans; Inflammatory Bowel Diseases; Melaton | 2011 |
Sleep and circadian rhythm dysregulation in schizophrenia.
Topics: Antipsychotic Agents; Chronic Disease; Circadian Rhythm; Humans; Melatonin; Schizophrenia; Schizophr | 2013 |
Is melatonin likely to help children with neurodevelopmental disability and chronic severe sleep problems?
Topics: Child, Preschool; Chronic Disease; Developmental Disabilities; Female; Humans; Learning Disabilities | 2002 |
Pain in the brain: are hormones to blame?
Topics: Adrenal Glands; Affect; Animals; Brain; Chronic Disease; Female; Growth Hormone; Hormones; Humans; H | 2003 |
The basic physiology and pathophysiology of melatonin.
Topics: Adaptation, Physiological; Chronic Disease; Circadian Rhythm; Humans; Melatonin; Photoperiod; Sleep; | 2005 |
Treating chronobiological components of chronic insomnia.
Topics: Behavior Therapy; Biological Clocks; Body Temperature; Chronic Disease; Chronotherapy; Circadian Rhy | 2007 |
Use of melatonin in the treatment of paediatric sleep disorders.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Disabled Persons; | 1996 |
Pharmacological actions of melatonin in acute and chronic inflammation.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Inflammation; Melatonin; Oxidants; Oxidative Stress | 2002 |
Successful treatment of multiple sclerosis with magnetic fields.
Topics: Brain; Brain Diseases; Chronic Disease; Demyelinating Diseases; Electromagnetic Fields; Female; Huma | 1992 |
[The most frequent hormonal disorders found in chronic hepatopathy].
Topics: Adrenocorticotropic Hormone; Brain; Calcifediol; Calcium; Chronic Disease; Estradiol; Estrogens; Fem | 1985 |
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese | 1971 |
14 trials available for melatonin and Chronic Disease
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study.
Topics: Adult; Arterial Pressure; Chronic Disease; Clonidine; Endoscopy; Female; Heart Rate; Hemodynamics; H | 2014 |
Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain.
Topics: Analysis of Variance; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Central Nervous Syst | 2015 |
Safety and subjective sleep effects of ramelteon administration in adults and older adults with chronic primary insomnia: a 1-year, open-label study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Indenes; | 2009 |
Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Circadian Rhythm; Female; Humans; Intel | 2010 |
Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study.
Topics: Adjuvants, Immunologic; Adolescent; Aged; Analgesics; Chronic Disease; Circadian Rhythm; Cluster Hea | 2002 |
Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.
Topics: Antioxidants; Child; Chronic Disease; Double-Blind Method; Female; Health Status; Humans; Male; Mela | 2003 |
Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin.
Topics: Antioxidants; Chronic Disease; Cytokines; Humans; Infant, Newborn; Infant, Premature; Lung Diseases; | 2004 |
An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia.
Topics: Adolescent; Adult; Chronic Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Bli | 2006 |
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Chronic Disease; Cir | 2007 |
Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Aged; Central Nervous System Depressants; Child; Child, Preschool; Chronic Diseas | 2008 |
The treatment of sleep disorders with melatonin.
Topics: Adolescent; Blindness; Child; Child, Preschool; Chronic Disease; Circadian Rhythm; Disabled Persons; | 1994 |
Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Antipsychotic Agents; Chronic Disease; Corpus Striatum | 2001 |
The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Circadian Rhythm; Double-Blind Method; Female; H | 1991 |
65 other studies available for melatonin and Chronic Disease
| Article | Year |
|---|---|
Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis.
Topics: ADAM17 Protein; Animals; Apoptosis; Chronic Disease; Cytokines; Hippocampus; Melatonin; Neuroinflamm | 2022 |
The evaluation of melatonin levels in chronic spontaneous urticaria: A case control study.
Topics: Adult; Case-Control Studies; Chronic Disease; Chronic Urticaria; Female; Humans; Melatonin; Quality | 2023 |
THE EFFECTIVENESS OF MELATONIN IN THE COMPLEX TREATMENT OF HYPERTENSION IN PATIENTS WITH STAGE 5 CHRONIC KIDNEY DISEASE.
Topics: Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Centra | 2020 |
Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats.
Topics: Animals; Antioxidants; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Inflammation; Lung; Melato | 2017 |
Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.
Topics: Adrenal Glands; Animals; Catecholamines; Chronic Disease; Depression; Disease Models, Animal; Gene E | 2019 |
Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cell Adhesion Molecules; Chronic Disease; Endothelium, Vascu | 2013 |
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice.
Topics: Animals; Behavior, Animal; Chronic Disease; Circadian Rhythm; Circadian Rhythm Signaling Peptides an | 2014 |
Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Chronic Disease; Cytokines; Gene Expression R | 2015 |
Immunomodulatory properties and anti-apoptotic effects of zinc and melatonin in an experimental model of chronic Chagas disease.
Topics: Animals; Antigens, CD; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Separ | 2015 |
Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation.
Topics: Animals; Biomarkers; Chronic Disease; Hippocampus; Male; Maze Learning; Melatonin; Memory; Memory Di | 2016 |
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Cardiotonic Agents; Cell Line; Chro | 2015 |
Time-dependent miR-16 serum fluctuations together with reciprocal changes in the expression level of miR-16 in mesocortical circuit contribute to stress resilient phenotype in chronic mild stress - An animal model of depression.
Topics: Anhedonia; Animals; Biomarkers; Chronic Disease; Corticosterone; Depressive Disorder; Dietary Sucros | 2016 |
Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia.
Topics: Animals; Antioxidants; Atherosclerosis; Cholesterol, Dietary; Chronic Disease; Disease Models, Anima | 2016 |
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.
Topics: Aging; Animals; Antioxidants; Cell Proliferation; Chronic Disease; Cytokines; Drugs, Chinese Herbal; | 2016 |
Gestational Chronodisruption Impairs Circadian Physiology in Rat Male Offspring, Increasing the Risk of Chronic Disease.
Topics: Aldosterone; Animals; Blood Pressure; Body Temperature; Chronic Disease; Circadian Rhythm; CLOCK Pro | 2016 |
Exogenous daytime melatonin modulates response of adolescent mice in a repeated unpredictable stress paradigm.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Antioxidants; Behavior, Animal; Biomarkers; Brain; Chroni | 2017 |
Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment.
Topics: Animals; Anxiety; Chronic Disease; Dopamine; Gene Expression Regulation, Enzymologic; Grooming; Hipp | 2016 |
Tryptophan free diet delays healing of chronic gastric ulcers in rat.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Chronic Disease; Cyclooxygenase 2; Diet; Gastric Muco | 2008 |
Interaction of chronic sleep restriction and circadian system in humans.
Topics: Adult; Chronic Disease; Female; Humans; Male; Melatonin; Sleep Deprivation; Sleep Disorders, Circadi | 2008 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia.
Topics: Affect; Attention Deficit Disorder with Hyperactivity; Central Nervous System Depressants; Chi-Squar | 2009 |
Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats.
Topics: Animals; Brain Ischemia; Chronic Disease; Female; Glutathione; Hippocampus; Histocytochemistry; HSP7 | 2009 |
A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats.
Topics: Analysis of Variance; Animals; Chronic Disease; Dextromethorphan; Dose-Response Relationship, Drug; | 2009 |
[Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease].
Topics: Animals; Animals, Newborn; Antioxidants; Chronic Disease; Female; Hyperoxia; Lung; Lung Diseases; Ma | 2009 |
Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats.
Topics: Alcohol-Induced Disorders; Animals; Antioxidants; Ascorbic Acid; Catalase; Central Nervous System De | 2009 |
Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study).
Topics: Aged; Body Temperature; Chronic Disease; Circadian Rhythm; Female; Humans; Hydrocortisone; Kidney; K | 2010 |
[An increased sensitivity of the mitochondrial permeability transition pore to calcium in the heart of rats with chronic deficiency of nigrostriatal dopamine].
Topics: Animals; Calcium; Chronic Disease; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hear | 2009 |
Headaches and pineal cysts.
Topics: Adult; Central Nervous System Cysts; Chronic Disease; Disease Progression; Gonadal Steroid Hormones; | 2010 |
Complementary and alternative medicine used by children in military pediatric clinics.
Topics: Adult; Age Factors; Ambulatory Care Facilities; Caregivers; Child; Child Care; Chronic Disease; Comp | 2011 |
[Sleep disorder and pain: the good hypnotic].
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Behavior Therapy | 2011 |
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyp | 2011 |
Melatonin and zinc treatment: distinctive modulation of cytokine production in chronic experimental Trypanosoma cruzi infection.
Topics: Animals; Antigens, CD; Cell Count; Cell Proliferation; Chagas Disease; Chronic Disease; Concanavalin | 2011 |
Melatonin in Chagas' disease. Possible therapeutic value.
Topics: Animals; Antioxidants; Central Nervous System Depressants; Chagas Cardiomyopathy; Chagas Disease; Ch | 2011 |
Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: protection by melatonin and cranberry flavonoids.
Topics: Acute Disease; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; | 2012 |
Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin.
Topics: Animals; Antioxidants; Blotting, Western; Chronic Disease; Extracellular Signal-Regulated MAP Kinase | 2012 |
Hypnotic drug use among 0-17 year olds during 2004-2011: a nationwide prescription database study.
Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Databases, Factual; Drug Prescriptions; Drug U | 2012 |
Effect of melatonin on chronic bladder-ischaemia-associated changes in rat bladder function.
Topics: Animals; Chronic Disease; Ischemia; Male; Melatonin; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2013 |
Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome.
Topics: Animals; Anovulation; Chronic Disease; Female; Light; Melatonin; Ovariectomy; Ovary; Pineal Gland; P | 2004 |
Role of melatonin in reducing water avoidance stress-induced degeneration of the liver.
Topics: Acute Disease; Animals; Avoidance Learning; Chronic Disease; Free Radical Scavengers; Glutathione; L | 2005 |
[Influence of melatonin, serotonin and gastrin on streaming of chronic gastritis at elderly patients].
Topics: Aged; Apoptosis; Chronic Disease; Disease Progression; Enterochromaffin Cells; Gastric Mucosa; Gastr | 2005 |
[Prescriptions for insomnia].
Topics: Chronic Disease; Drug Stability; Humans; Hypnotics and Sedatives; Melatonin; Nonprescription Drugs; | 2005 |
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats.
Topics: Animals; Biomarkers; Chronic Disease; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; G | 2006 |
Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?
Topics: Chronic Disease; Circadian Rhythm; Female; Humans; Kidney Diseases; Male; Melatonin; Middle Aged; Ne | 2006 |
Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery.
Topics: Animals; Chronic Disease; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Melatonin; | 2008 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight.
Topics: Adult; Aged; Body Weight; Chronic Disease; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; S | 1982 |
Melatonin for treatment of chronic refractory sarcoidosis.
Topics: Adult; Chronic Disease; Dyspnea; Female; Humans; Lung Diseases; Melatonin; Middle Aged; Sarcoidosis; | 1995 |
Seasonal variation in the dexamethasone suppression test: a longitudinal study in chronic schizophrenics and in healthy subjects.
Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dexamethasone; F | 1994 |
Rapid normalization of visual evoked potentials by picoTesla range magnetic fields in chronic progressive multiple sclerosis.
Topics: Brain; Chronic Disease; Evoked Potentials, Visual; Humans; Magnetic Resonance Imaging; Magnetics; Me | 1994 |
Improvement by picoTesla range magnetic fields of perceptual-motor performance and visual memory in a patient with chronic progressive multiple sclerosis.
Topics: Chronic Disease; Electromagnetic Fields; Humans; Male; Melatonin; Memory; Middle Aged; Multiple Scle | 1994 |
Melatonin treatment of chronic sleep disorders.
Topics: Administration, Oral; Chronic Disease; Humans; Melatonin; Sleep Wake Disorders; Treatment Outcome; W | 1995 |
[Melatonin excretion in patients with depression under the action of light of increased intensity].
Topics: Adolescent; Adult; Bipolar Disorder; Chronic Disease; Depressive Disorder, Major; Female; Fluorometr | 1995 |
Melatonin secretion during fluvoxamine treatment in medicated chronic schizophrenic patients: evidence for the development of tolerance to selective serotonin re-uptake inhibitor.
Topics: Adult; Biomarkers; Chronic Disease; Dose-Response Relationship, Drug; Drug Tolerance; Female; Fluvox | 1996 |
Premature ageing: the link between psychosocial risk factors and disease.
Topics: Aging; Chronic Disease; Coronary Disease; Health Status; Humans; Life Style; Melatonin; Models, Theo | 1996 |
A schizophrenic patient with an arrhythmic circadian rest-activity cycle.
Topics: Adult; Antipsychotic Agents; Bed Rest; Body Temperature; Catatonia; Chronic Disease; Circadian Rhyth | 1997 |
Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep-wake rhythm disorders.
Topics: Adult; Chronic Disease; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; Radioimmunoassay; Sl | 1998 |
Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chronic Disease; Female; Follow-Up | 2000 |
The effects of melatonin on the behavioural disturbances induced by chronic mild stress in C3H/He mice.
Topics: Animals; Antioxidants; Behavior, Animal; Chronic Disease; Exploratory Behavior; Fluoxetine; Male; Me | 1999 |
Melatonin replacement therapy in a child with a pineal tumor.
Topics: Adolescent; Brain Neoplasms; Child; Chronic Disease; Dose-Response Relationship, Drug; Female; Hormo | 2001 |
[Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis].
Topics: Chronic Disease; Common Bile Duct Diseases; Diagnosis, Differential; Gastric Mucosa; Humans; Melaton | 2001 |
Hypothalamic involvement in chronic migraine.
Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Chronobiology Disorders; Circadian Rhythm; Co | 2001 |
[Melatonin treatment of a blind child with serious sleep disorders].
Topics: Blindness; Child, Preschool; Chronic Disease; Developmental Disabilities; Humans; Male; Melatonin; P | 2002 |
Protective effect of melatonin in a chronic experimental model of Parkinson's disease.
Topics: Animals; Axons; Cell Death; Chronic Disease; Disease Models, Animal; DNA Fragmentation; Dose-Respons | 2002 |
[Disordered melatonin metabolism in chronic circulatory insufficiency].
Topics: Aged; Arrhythmias, Cardiac; Cardiovascular Diseases; Chronic Disease; Coronary Disease; Humans; Hype | 1978 |
Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin.
Topics: Adult; Chronic Disease; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydrocortisone; Hydr | 1986 |