Page last updated: 2024-10-19

melatonin and Cholestasis

melatonin has been researched along with Cholestasis in 27 studies

Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).

Research Excerpts

ExcerptRelevanceReference
"The present study investigated the anti‑cholestatic effect of melatonin (MT) against α‑naphthyl isothiocyanate (ANIT)‑induced liver injury in rats and screened for potential biomarkers of cholestasis."7.88Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses. ( Deng, H; Deng, X; Li, Y; Shi, S; Sun, L; Wang, D; Xu, Z; Yu, H; Zeng, B; Zheng, Z; Zhong, X, 2018)
"Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury."7.85Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017)
" The aim of this study was to investigate the protective effects in rat maternal and fetal livers as also the placenta of melatonin or silymarin against the oxidative stress and apoptosis induced by maternal obstructive cholestasis during the last third of pregnancy (OCP)."7.74Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. ( Castaño, B; Gonzalez-Buitrago, JM; Marin, JJ; Perez, MJ, 2007)
" In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis."7.72Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004)
" We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury."7.72Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004)
"Cholestasis is a devastating liver condition which is increasing in prevalence worldwide; however, its underlying pathogenic mechanisms remain to be fully elucidated."5.51Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats. ( Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X, 2019)
"Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis."5.48Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018)
"Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes."3.91Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. ( Alpini, G; Ceci, L; Chen, L; Fabris, L; Francis, H; Gaudio, E; Glaser, S; Huang, Q; Invernizzi, P; Kyritsi, K; Liangpunsakul, S; Meng, F; O'Brien, A; Onori, P; Sybenga, A; Venter, J; Wu, C; Wu, N; Xie, L; Zawieja, D; Zhou, T, 2019)
"The present study investigated the anti‑cholestatic effect of melatonin (MT) against α‑naphthyl isothiocyanate (ANIT)‑induced liver injury in rats and screened for potential biomarkers of cholestasis."3.88Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses. ( Deng, H; Deng, X; Li, Y; Shi, S; Sun, L; Wang, D; Xu, Z; Yu, H; Zeng, B; Zheng, Z; Zhong, X, 2018)
"Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury."3.85Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017)
" The aim of this study was to investigate the protective effects in rat maternal and fetal livers as also the placenta of melatonin or silymarin against the oxidative stress and apoptosis induced by maternal obstructive cholestasis during the last third of pregnancy (OCP)."3.74Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. ( Castaño, B; Gonzalez-Buitrago, JM; Marin, JJ; Perez, MJ, 2007)
" Melatonin, even at low dose, is an efficient agent in reducing negative parameters of cholestasis."3.73Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. ( Emre, MH; Esrefoglu, M; Gül, M; Polat, A; Selimoglu, MA, 2005)
"The preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate (ANIT)-induced acute liver injury with cholestasis was examined in rats treated once with the hepatotoxin [75 mg/kg body weight (BW), i."3.72Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats. ( Kishikawa, T; Kongo, M; Ohta, Y, 2003)
" In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis."3.72Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004)
" We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury."3.72Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004)
"The aims of the present study were first to compare the effects of melatonin and vitamin E on the cholestasis syndrome and their protective effect on liver injury, and second, to evaluate the activity of antioxidant enzymes after treatment with these antioxidant drugs."3.71Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats. ( Cruz, A; Gascon, F; Gómez, M; Montilla, P; Muñoz, MC; Padillo, FJ; Pera, C; Túnez, I, 2001)
"The protective effect of melatonin against alpha-naphthylisothiocyanate (ANIT)-induced liver injury with cholestasis was examined in rats injected once with the toxicant (75 mg/kg body weight (BW))."3.70Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats. ( Harada, N; Ishiguro, I; Kongo, M; Ohta, Y; Sasaki, E, 2000)
"Melatonin reduces biliary damage and liver fibrosis in cholestatic models by interaction with melatonin receptors 1A (MT1) and 1B (MT2)."1.72Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury. ( Alpini, G; Baiocchi, L; Carpino, G; Ceci, L; Chen, L; Ekser, B; Franchitto, A; Francis, H; Gaudio, E; Glaser, S; Kennedy, L; Kyritsi, K; Mancinelli, R; Meadows, V; Onori, P; Sato, K; Wu, N; Zhou, T, 2022)
"Cholestasis is a devastating liver condition which is increasing in prevalence worldwide; however, its underlying pathogenic mechanisms remain to be fully elucidated."1.51Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats. ( Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X, 2019)
"Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis."1.48Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018)
"Melatonin-treated BDL rats received daily melatonin 100 mg/kg/day via intraperitoneal injection."1.40Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats. ( Aktas, C; Erboga, M; Kanter, M; Mete, R; Oran, M, 2014)
"Treatment with melatonin decreased lipid peroxide synthesis, and permitted a recovery of both reduced glutathione and scavenger enzyme activity."1.32Effect of melatonin on cholestatic oxidative stress under constant light exposure. ( Briceño, J; Cruz, A; Granados, J; Montilla, P; Muñoz, MC; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2003)
"Treatment with melatonin decreased the renal lipid peroxidation, and both the reduced glutathione as well as the scavenger enzyme activity recovered."1.31Melatonin protects against renal oxidative stress after obstructive jaundice in rats. ( Cruz, A; Granados, J; Montilla, P; Muñoz, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2001)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (55.56)29.6817
2010's10 (37.04)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Wu, N4
Carpino, G4
Ceci, L3
Baiocchi, L2
Francis, H6
Kennedy, L3
Zhou, T4
Chen, L3
Sato, K1
Kyritsi, K4
Meadows, V1
Ekser, B2
Franchitto, A5
Mancinelli, R5
Onori, P6
Gaudio, E6
Glaser, S8
Alpini, G8
Owen, T1
Kundu, D1
Sybenga, A2
Isidan, A1
McMillin, M1
DeMorrow, S4
Venter, J5
Grant, S1
Giang, T1
Greene, JF1
Jefferson, B1
Meng, F6
Ehrlich, L1
Scrushy, M1
Lairmore, TC1
Yu, H2
Li, Y2
Xu, Z2
Wang, D2
Shi, S2
Deng, H2
Zeng, B2
Zheng, Z1
Sun, L1
Deng, X2
Zhong, X2
Esmaeili, A1
Namazi, S1
Shi, X1
Wang, Y1
O'Brien, A1
Xie, L1
Wu, C1
Fabris, L1
Invernizzi, P1
Zawieja, D1
Liangpunsakul, S1
Huang, Q1
Han, Y3
Ray, D1
Greene, J1
Renzi, A3
Fuentes-Broto, L1
Martínez-Ballarín, E1
Miana-Mena, J1
Berzosa, C1
Piedrafita, E1
Cebrián, I1
Reiter, RJ2
García, JJ1
White, M2
Alvaro, D1
Ueno, Y2
Dusio, G1
Jensen, KJ1
Greene, JJ1
Aktas, C1
Kanter, M1
Erboga, M1
Mete, R1
Oran, M1
Ohta, Y4
Kongo, M3
Kishikawa, T2
Bülbüller, N1
Akkuş, MA1
Cetinkaya, Z1
Ilhan, YS1
Ozercan, I1
Kirkil, C1
Doğru, O1
Cruz, A4
Padillo, FJ4
Granados, J2
Túnez, I4
Muñoz, MC2
Briceño, J2
Pera-Madrazo, C3
Montilla, P4
Navarrete, C1
Bujalance, I1
Gallardo, JI1
Marchal, T1
Caballero, R1
Muntané, J1
Barlas, A1
Cevik, H1
Arbak, S1
Bangir, D1
Sener, G1
Yeğen, C1
Yeğen, BC1
Esrefoglu, M1
Gül, M1
Emre, MH2
Polat, A2
Selimoglu, MA1
Kongo-Nishimura, M1
Imai, Y1
Kitagawa, A1
Perez, MJ1
Castaño, B1
Gonzalez-Buitrago, JM1
Marin, JJ1
Sasaki, E1
Ishiguro, I1
Harada, N1
Tan, DX1
Karbownik, M1
Muñoz, C1
Gascon, F1
Gómez, M1
Pera, C1

Reviews

1 review available for melatonin and Cholestasis

ArticleYear
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.
    Clinics and research in hepatology and gastroenterology, 2018, Volume: 42, Issue:4

    Topics: Animals; Arginine Vasopressin; Biliary Tract; Cell Proliferation; Cholangitis; Cholestasis; Epitheli

2018

Trials

1 trial available for melatonin and Cholestasis

ArticleYear
Effects of melatonin and lactulose on the liver and kidneys in rats with obstructive jaundice.
    Pediatric surgery international, 2002, Volume: 18, Issue:8

    Topics: Analysis of Variance; Animals; Cholestasis; Cholesterol; Kidney Diseases; Lactulose; Liver; Liver Di

2002

Other Studies

25 other studies available for melatonin and Cholestasis

ArticleYear
Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.
    Hepatology (Baltimore, Md.), 2022, Volume: 75, Issue:4

    Topics: Animals; Cholestasis; Liver Cirrhosis; Melatonin; Mice; Mice, Knockout; Receptor, Melatonin, MT1; Re

2022
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
    Cellular and molecular gastroenterology and hepatology, 2022, Volume: 14, Issue:4

    Topics: Animals; Cholangitis, Sclerosing; Cholestasis; Disease Models, Animal; Drinking Water; Glutathione;

2022
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2017, Nov-01, Volume: 313, Issue:5

    Topics: Animals; Bile Ducts; Cell Proliferation; Central Nervous System Depressants; Cholestasis; Disease Mo

2017
Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses.
    International journal of molecular medicine, 2018, Volume: 42, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Cholestasis; Liver; Male; Melatonin; Metabolic Networks and Pathw

2018
Is melatonin effective for pruritus caused by liver disease?
    Medical hypotheses, 2018, Volume: 121

    Topics: Animals; Cholestasis; Dermatitis, Atopic; Humans; Liver Diseases; Lysophospholipids; Melatonin; Mice

2018
Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases;

2019
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
    Biochimica et biophysica acta. Molecular basis of disease, 2019, 06-01, Volume: 1865, Issue:6

    Topics: Animals; Arylalkylamine N-Acetyltransferase; Bile Ducts, Intrahepatic; Cell Line; Cell Proliferation

2019
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Nov-01, Volume: 307, Issue:9

    Topics: Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Bile Acids and Salts; Bile

2014
Lipid and protein oxidation in hepatic homogenates and cell membranes exposed to bile acids.
    Free radical research, 2009, Volume: 43, Issue:11

    Topics: Animals; Antioxidants; Bile Acids and Salts; Cell Membrane; Cholestasis; Humans; Lipid Peroxidation;

2009
Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 301, Issue:4

    Topics: Animals; ARNTL Transcription Factors; Bicarbonates; Bile Ducts; Cell Proliferation; Cholestasis; CLO

2011
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:3

    Topics: Animals; Anion Transport Proteins; Antioxidants; Antiporters; Apoptosis; Arylalkylamine N-Acetyltran

2013
Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats.
    Toxicology and industrial health, 2014, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Cell Proliferation; Cholestasis; Common Bile Duct; Fibrosis; Glutathione; Hepato

2014
Melatonin exerts a therapeutic effect on cholestatic liver injury in rats with bile duct ligation.
    Journal of pineal research, 2003, Volume: 34, Issue:2

    Topics: Animals; Bile Ducts; Cholestasis; Lipid Peroxidation; Liver; Male; Melatonin; Rats; Rats, Wistar; Th

2003
Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats.
    Journal of pineal research, 2003, Volume: 34, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Catalase; Cholestasis; Dose-Response Relationship,

2003
Effect of melatonin on cholestatic oxidative stress under constant light exposure.
    Cell biochemistry and function, 2003, Volume: 21, Issue:4

    Topics: Animals; Cholestasis; Glutathione; Light; Male; Malondialdehyde; Melatonin; Oxidative Stress; Rats;

2003
Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis.
    Free radical research, 2004, Volume: 38, Issue:7

    Topics: Animals; Antioxidants; Cell Death; Cholestasis; Disease Models, Animal; Hepatocytes; Jaundice, Obstr

2004
Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils.
    Journal of pineal research, 2004, Volume: 37, Issue:4

    Topics: Animals; Antioxidants; Bile Ducts; Cholestasis; Female; Glutathione; Inflammation; Kidney; Liver; Lu

2004
Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats.
    World journal of gastroenterology, 2005, Apr-07, Volume: 11, Issue:13

    Topics: Animals; Antioxidants; Cholestasis; Cholestasis, Extrahepatic; Common Bile Duct; Dose-Response Relat

2005
Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats.
    Journal of gastroenterology, 2006, Volume: 41, Issue:5

    Topics: Animals; Aspirin; Bile Ducts; Catalase; Cholestasis; Disease Models, Animal; Glutathione Peroxidase;

2006
Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment.
    Journal of pineal research, 2007, Volume: 42, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cholesterol; Male; Melatonin; Rats; Rats, Wistar

2007
Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio.
    Journal of pineal research, 2007, Volume: 43, Issue:2

    Topics: Animals; Apoptosis; Body Weight; Cholestasis; Female; Glutathione; Lipid Peroxidation; Liver; Melato

2007
Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats.
    Journal of pineal research, 2000, Volume: 29, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Asparta

2000
Cholelithiasis, oxidative stress and melatonin.
    Journal of pineal research, 2001, Volume: 30, Issue:2

    Topics: Animals; Antioxidants; Cholelithiasis; Cholestasis; Guinea Pigs; Humans; Melatonin; Oxidative Stress

2001
Melatonin protects against renal oxidative stress after obstructive jaundice in rats.
    European journal of pharmacology, 2001, Aug-10, Volume: 425, Issue:2

    Topics: Animals; Antioxidants; Cholestasis; Disease Models, Animal; Kidney Function Tests; Male; Melatonin;

2001
Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats.
    Journal of pineal research, 2001, Volume: 31, Issue:2

    Topics: Animals; Antioxidants; Bile Ducts, Extrahepatic; Cholestasis; Ligation; Lipid Peroxidation; Liver; M

2001