melatonin has been researched along with Cholestasis in 27 studies
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the anti‑cholestatic effect of melatonin (MT) against α‑naphthyl isothiocyanate (ANIT)‑induced liver injury in rats and screened for potential biomarkers of cholestasis." | 7.88 | Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses. ( Deng, H; Deng, X; Li, Y; Shi, S; Sun, L; Wang, D; Xu, Z; Yu, H; Zeng, B; Zheng, Z; Zhong, X, 2018) |
| "Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury." | 7.85 | Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017) |
| " The aim of this study was to investigate the protective effects in rat maternal and fetal livers as also the placenta of melatonin or silymarin against the oxidative stress and apoptosis induced by maternal obstructive cholestasis during the last third of pregnancy (OCP)." | 7.74 | Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. ( Castaño, B; Gonzalez-Buitrago, JM; Marin, JJ; Perez, MJ, 2007) |
| " In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis." | 7.72 | Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 7.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "Cholestasis is a devastating liver condition which is increasing in prevalence worldwide; however, its underlying pathogenic mechanisms remain to be fully elucidated." | 5.51 | Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats. ( Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X, 2019) |
| "Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis." | 5.48 | Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018) |
| "Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes." | 3.91 | Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. ( Alpini, G; Ceci, L; Chen, L; Fabris, L; Francis, H; Gaudio, E; Glaser, S; Huang, Q; Invernizzi, P; Kyritsi, K; Liangpunsakul, S; Meng, F; O'Brien, A; Onori, P; Sybenga, A; Venter, J; Wu, C; Wu, N; Xie, L; Zawieja, D; Zhou, T, 2019) |
| "The present study investigated the anti‑cholestatic effect of melatonin (MT) against α‑naphthyl isothiocyanate (ANIT)‑induced liver injury in rats and screened for potential biomarkers of cholestasis." | 3.88 | Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses. ( Deng, H; Deng, X; Li, Y; Shi, S; Sun, L; Wang, D; Xu, Z; Yu, H; Zeng, B; Zheng, Z; Zhong, X, 2018) |
| "Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury." | 3.85 | Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017) |
| " The aim of this study was to investigate the protective effects in rat maternal and fetal livers as also the placenta of melatonin or silymarin against the oxidative stress and apoptosis induced by maternal obstructive cholestasis during the last third of pregnancy (OCP)." | 3.74 | Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. ( Castaño, B; Gonzalez-Buitrago, JM; Marin, JJ; Perez, MJ, 2007) |
| " Melatonin, even at low dose, is an efficient agent in reducing negative parameters of cholestasis." | 3.73 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. ( Emre, MH; Esrefoglu, M; Gül, M; Polat, A; Selimoglu, MA, 2005) |
| "The preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate (ANIT)-induced acute liver injury with cholestasis was examined in rats treated once with the hepatotoxin [75 mg/kg body weight (BW), i." | 3.72 | Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats. ( Kishikawa, T; Kongo, M; Ohta, Y, 2003) |
| " In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis." | 3.72 | Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis. ( Briceño, J; Bujalance, I; Caballero, R; Cruz, A; Gallardo, JI; Marchal, T; Montilla, P; Muntané, J; Navarrete, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2004) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 3.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "The aims of the present study were first to compare the effects of melatonin and vitamin E on the cholestasis syndrome and their protective effect on liver injury, and second, to evaluate the activity of antioxidant enzymes after treatment with these antioxidant drugs." | 3.71 | Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats. ( Cruz, A; Gascon, F; Gómez, M; Montilla, P; Muñoz, MC; Padillo, FJ; Pera, C; Túnez, I, 2001) |
| "The protective effect of melatonin against alpha-naphthylisothiocyanate (ANIT)-induced liver injury with cholestasis was examined in rats injected once with the toxicant (75 mg/kg body weight (BW))." | 3.70 | Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats. ( Harada, N; Ishiguro, I; Kongo, M; Ohta, Y; Sasaki, E, 2000) |
| "Melatonin reduces biliary damage and liver fibrosis in cholestatic models by interaction with melatonin receptors 1A (MT1) and 1B (MT2)." | 1.72 | Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury. ( Alpini, G; Baiocchi, L; Carpino, G; Ceci, L; Chen, L; Ekser, B; Franchitto, A; Francis, H; Gaudio, E; Glaser, S; Kennedy, L; Kyritsi, K; Mancinelli, R; Meadows, V; Onori, P; Sato, K; Wu, N; Zhou, T, 2022) |
| "Cholestasis is a devastating liver condition which is increasing in prevalence worldwide; however, its underlying pathogenic mechanisms remain to be fully elucidated." | 1.51 | Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats. ( Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X, 2019) |
| "Melatonin has pleiotropic properties such as suppressive effects on serum level of autotaxin which relieves itching of atopic dermatitis." | 1.48 | Is melatonin effective for pruritus caused by liver disease? ( Esmaeili, A; Namazi, S, 2018) |
| "Melatonin-treated BDL rats received daily melatonin 100 mg/kg/day via intraperitoneal injection." | 1.40 | Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats. ( Aktas, C; Erboga, M; Kanter, M; Mete, R; Oran, M, 2014) |
| "Treatment with melatonin decreased lipid peroxide synthesis, and permitted a recovery of both reduced glutathione and scavenger enzyme activity." | 1.32 | Effect of melatonin on cholestatic oxidative stress under constant light exposure. ( Briceño, J; Cruz, A; Granados, J; Montilla, P; Muñoz, MC; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2003) |
| "Treatment with melatonin decreased the renal lipid peroxidation, and both the reduced glutathione as well as the scavenger enzyme activity recovered." | 1.31 | Melatonin protects against renal oxidative stress after obstructive jaundice in rats. ( Cruz, A; Granados, J; Montilla, P; Muñoz, C; Padillo, FJ; Pera-Madrazo, C; Túnez, I, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (55.56) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, N | 4 |
| Carpino, G | 4 |
| Ceci, L | 3 |
| Baiocchi, L | 2 |
| Francis, H | 6 |
| Kennedy, L | 3 |
| Zhou, T | 4 |
| Chen, L | 3 |
| Sato, K | 1 |
| Kyritsi, K | 4 |
| Meadows, V | 1 |
| Ekser, B | 2 |
| Franchitto, A | 5 |
| Mancinelli, R | 5 |
| Onori, P | 6 |
| Gaudio, E | 6 |
| Glaser, S | 8 |
| Alpini, G | 8 |
| Owen, T | 1 |
| Kundu, D | 1 |
| Sybenga, A | 2 |
| Isidan, A | 1 |
| McMillin, M | 1 |
| DeMorrow, S | 4 |
| Venter, J | 5 |
| Grant, S | 1 |
| Giang, T | 1 |
| Greene, JF | 1 |
| Jefferson, B | 1 |
| Meng, F | 6 |
| Ehrlich, L | 1 |
| Scrushy, M | 1 |
| Lairmore, TC | 1 |
| Yu, H | 2 |
| Li, Y | 2 |
| Xu, Z | 2 |
| Wang, D | 2 |
| Shi, S | 2 |
| Deng, H | 2 |
| Zeng, B | 2 |
| Zheng, Z | 1 |
| Sun, L | 1 |
| Deng, X | 2 |
| Zhong, X | 2 |
| Esmaeili, A | 1 |
| Namazi, S | 1 |
| Shi, X | 1 |
| Wang, Y | 1 |
| O'Brien, A | 1 |
| Xie, L | 1 |
| Wu, C | 1 |
| Fabris, L | 1 |
| Invernizzi, P | 1 |
| Zawieja, D | 1 |
| Liangpunsakul, S | 1 |
| Huang, Q | 1 |
| Han, Y | 3 |
| Ray, D | 1 |
| Greene, J | 1 |
| Renzi, A | 3 |
| Fuentes-Broto, L | 1 |
| Martínez-Ballarín, E | 1 |
| Miana-Mena, J | 1 |
| Berzosa, C | 1 |
| Piedrafita, E | 1 |
| Cebrián, I | 1 |
| Reiter, RJ | 2 |
| García, JJ | 1 |
| White, M | 2 |
| Alvaro, D | 1 |
| Ueno, Y | 2 |
| Dusio, G | 1 |
| Jensen, KJ | 1 |
| Greene, JJ | 1 |
| Aktas, C | 1 |
| Kanter, M | 1 |
| Erboga, M | 1 |
| Mete, R | 1 |
| Oran, M | 1 |
| Ohta, Y | 4 |
| Kongo, M | 3 |
| Kishikawa, T | 2 |
| Bülbüller, N | 1 |
| Akkuş, MA | 1 |
| Cetinkaya, Z | 1 |
| Ilhan, YS | 1 |
| Ozercan, I | 1 |
| Kirkil, C | 1 |
| Doğru, O | 1 |
| Cruz, A | 4 |
| Padillo, FJ | 4 |
| Granados, J | 2 |
| Túnez, I | 4 |
| Muñoz, MC | 2 |
| Briceño, J | 2 |
| Pera-Madrazo, C | 3 |
| Montilla, P | 4 |
| Navarrete, C | 1 |
| Bujalance, I | 1 |
| Gallardo, JI | 1 |
| Marchal, T | 1 |
| Caballero, R | 1 |
| Muntané, J | 1 |
| Barlas, A | 1 |
| Cevik, H | 1 |
| Arbak, S | 1 |
| Bangir, D | 1 |
| Sener, G | 1 |
| Yeğen, C | 1 |
| Yeğen, BC | 1 |
| Esrefoglu, M | 1 |
| Gül, M | 1 |
| Emre, MH | 2 |
| Polat, A | 2 |
| Selimoglu, MA | 1 |
| Kongo-Nishimura, M | 1 |
| Imai, Y | 1 |
| Kitagawa, A | 1 |
| Perez, MJ | 1 |
| Castaño, B | 1 |
| Gonzalez-Buitrago, JM | 1 |
| Marin, JJ | 1 |
| Sasaki, E | 1 |
| Ishiguro, I | 1 |
| Harada, N | 1 |
| Tan, DX | 1 |
| Karbownik, M | 1 |
| Muñoz, C | 1 |
| Gascon, F | 1 |
| Gómez, M | 1 |
| Pera, C | 1 |
1 review available for melatonin and Cholestasis
| Article | Year |
|---|---|
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.
Topics: Animals; Arginine Vasopressin; Biliary Tract; Cell Proliferation; Cholangitis; Cholestasis; Epitheli | 2018 |
1 trial available for melatonin and Cholestasis
| Article | Year |
|---|---|
Effects of melatonin and lactulose on the liver and kidneys in rats with obstructive jaundice.
Topics: Analysis of Variance; Animals; Cholestasis; Cholesterol; Kidney Diseases; Lactulose; Liver; Liver Di | 2002 |
25 other studies available for melatonin and Cholestasis
| Article | Year |
|---|---|
Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.
Topics: Animals; Cholestasis; Liver Cirrhosis; Melatonin; Mice; Mice, Knockout; Receptor, Melatonin, MT1; Re | 2022 |
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
Topics: Animals; Cholangitis, Sclerosing; Cholestasis; Disease Models, Animal; Drinking Water; Glutathione; | 2022 |
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.
Topics: Animals; Bile Ducts; Cell Proliferation; Central Nervous System Depressants; Cholestasis; Disease Mo | 2017 |
Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses.
Topics: Animals; Antioxidants; Biomarkers; Cholestasis; Liver; Male; Melatonin; Metabolic Networks and Pathw | 2018 |
Is melatonin effective for pruritus caused by liver disease?
Topics: Animals; Cholestasis; Dermatitis, Atopic; Humans; Liver Diseases; Lysophospholipids; Melatonin; Mice | 2018 |
Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; | 2019 |
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Bile Ducts, Intrahepatic; Cell Line; Cell Proliferation | 2019 |
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
Topics: Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Bile Acids and Salts; Bile | 2014 |
Lipid and protein oxidation in hepatic homogenates and cell membranes exposed to bile acids.
Topics: Animals; Antioxidants; Bile Acids and Salts; Cell Membrane; Cholestasis; Humans; Lipid Peroxidation; | 2009 |
Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.
Topics: Animals; ARNTL Transcription Factors; Bicarbonates; Bile Ducts; Cell Proliferation; Cholestasis; CLO | 2011 |
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats.
Topics: Animals; Anion Transport Proteins; Antioxidants; Antiporters; Apoptosis; Arylalkylamine N-Acetyltran | 2013 |
Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats.
Topics: Animals; Apoptosis; Cell Proliferation; Cholestasis; Common Bile Duct; Fibrosis; Glutathione; Hepato | 2014 |
Melatonin exerts a therapeutic effect on cholestatic liver injury in rats with bile duct ligation.
Topics: Animals; Bile Ducts; Cholestasis; Lipid Peroxidation; Liver; Male; Melatonin; Rats; Rats, Wistar; Th | 2003 |
Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Catalase; Cholestasis; Dose-Response Relationship, | 2003 |
Effect of melatonin on cholestatic oxidative stress under constant light exposure.
Topics: Animals; Cholestasis; Glutathione; Light; Male; Malondialdehyde; Melatonin; Oxidative Stress; Rats; | 2003 |
Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis.
Topics: Animals; Antioxidants; Cell Death; Cholestasis; Disease Models, Animal; Hepatocytes; Jaundice, Obstr | 2004 |
Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils.
Topics: Animals; Antioxidants; Bile Ducts; Cholestasis; Female; Glutathione; Inflammation; Kidney; Liver; Lu | 2004 |
Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats.
Topics: Animals; Antioxidants; Cholestasis; Cholestasis, Extrahepatic; Common Bile Duct; Dose-Response Relat | 2005 |
Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats.
Topics: Animals; Aspirin; Bile Ducts; Catalase; Cholestasis; Disease Models, Animal; Glutathione Peroxidase; | 2006 |
Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cholesterol; Male; Melatonin; Rats; Rats, Wistar | 2007 |
Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio.
Topics: Animals; Apoptosis; Body Weight; Cholestasis; Female; Glutathione; Lipid Peroxidation; Liver; Melato | 2007 |
Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Asparta | 2000 |
Cholelithiasis, oxidative stress and melatonin.
Topics: Animals; Antioxidants; Cholelithiasis; Cholestasis; Guinea Pigs; Humans; Melatonin; Oxidative Stress | 2001 |
Melatonin protects against renal oxidative stress after obstructive jaundice in rats.
Topics: Animals; Antioxidants; Cholestasis; Disease Models, Animal; Kidney Function Tests; Male; Melatonin; | 2001 |
Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats.
Topics: Animals; Antioxidants; Bile Ducts, Extrahepatic; Cholestasis; Ligation; Lipid Peroxidation; Liver; M | 2001 |