melatonin has been researched along with Chemical Dependence in 15 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results from this trial will examine whether melatonin has a role in withdrawing long-term benzodiazepine administration in schizophrenia patients." | 9.15 | Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol. ( Baandrup, L; Fagerlund, B; Glenthoj, BY; Gluud, C; Hansen, JL; Jennum, P; Lublin, H; Oranje, B; Winkel, P, 2011) |
| "The results from this trial will examine whether melatonin has a role in withdrawing long-term benzodiazepine administration in schizophrenia patients." | 5.15 | Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol. ( Baandrup, L; Fagerlund, B; Glenthoj, BY; Gluud, C; Hansen, JL; Jennum, P; Lublin, H; Oranje, B; Winkel, P, 2011) |
| " We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag." | 4.88 | Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012) |
| "Methadone maintenance treatment clinic." | 2.73 | Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. ( Adelson, M; Bar-Hamburger, R; Hetzroni, T; Peles, E; Schreiber, S, 2007) |
| " They were encouraged to reduce their benzodiazepine dosage 50% during week 2, 75% during weeks 3 and 4, and to discontinue benzodiazepine therapy completely during weeks 5 and 6." | 2.69 | Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. ( Garfinkel, D; Laudon, M; Wainstein, J; Zisapel, N, 1999) |
| "Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases." | 2.50 | Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014) |
| "Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM." | 1.31 | Hypothalamic involvement in chronic migraine. ( Abucham, J; Cipolla-Neto, J; Peres, MF; Sanchez del Rio, M; Seabra, ML; Silberstein, SD; Tufik, S; Zukerman, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, S | 1 |
| Guo, X | 1 |
| Chen, Z | 1 |
| Li, S | 1 |
| Liu, XA | 1 |
| Rosenqvist, TW | 1 |
| Osler, M | 1 |
| Wium-Andersen, MK | 1 |
| Wium-Andersen, IK | 1 |
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Miano, S | 1 |
| Peraita-Adrados, R | 1 |
| Cardinali, DP | 1 |
| Golombek, DA | 1 |
| Rosenstein, RE | 1 |
| Brusco, LI | 1 |
| Vigo, DE | 1 |
| Baandrup, L | 1 |
| Fagerlund, B | 1 |
| Jennum, P | 1 |
| Lublin, H | 1 |
| Hansen, JL | 1 |
| Winkel, P | 1 |
| Gluud, C | 1 |
| Oranje, B | 1 |
| Glenthoj, BY | 1 |
| Adan, A | 1 |
| Archer, SN | 1 |
| Hidalgo, MP | 1 |
| Di Milia, L | 1 |
| Natale, V | 1 |
| Randler, C | 1 |
| Postolache, TT | 1 |
| Hung, TM | 1 |
| Rosenthal, RN | 1 |
| Soriano, JJ | 1 |
| Montes, F | 1 |
| Stiller, JW | 1 |
| Peles, E | 1 |
| Hetzroni, T | 1 |
| Bar-Hamburger, R | 1 |
| Adelson, M | 1 |
| Schreiber, S | 1 |
| Hasler, BP | 1 |
| Bootzin, RR | 1 |
| Cousins, JC | 1 |
| Fridel, K | 1 |
| Wenk, GL | 1 |
| Wiley, JL | 1 |
| Dance, ME | 1 |
| Balster, RL | 1 |
| Bursztajn, HJ | 1 |
| Garfinkel, D | 1 |
| Zisapel, N | 1 |
| Wainstein, J | 1 |
| Laudon, M | 1 |
| Peres, MF | 1 |
| Sanchez del Rio, M | 1 |
| Seabra, ML | 1 |
| Tufik, S | 1 |
| Abucham, J | 1 |
| Cipolla-Neto, J | 1 |
| Silberstein, SD | 1 |
| Zukerman, E | 1 |
| Veit, I | 1 |
| Dietzel, M | 1 |
| Lesch, OM | 1 |
| Hermann, P | 1 |
| Birsak, L | 1 |
| Reschenhofer, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657] | Phase 4 | 120 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Prolonged-release Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia: a Randomized Clinical Trial[NCT01431092] | Phase 4 | 86 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398] | 71 participants (Actual) | Interventional | 2018-01-23 | Completed | |||
| [NCT00261183] | Phase 3 | 100 participants | Interventional | 2004-12-31 | Recruiting | ||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
6 reviews available for melatonin and Chemical Dependence
| Article | Year |
|---|---|
The roles of the circadian hormone melatonin in drug addiction.
Topics: Biological Clocks; Circadian Rhythm; Humans; Melatonin; Substance-Related Disorders | 2022 |
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
Pediatric insomnia: clinical, diagnosis, and treatment.
Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di | 2014 |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse.
Topics: Animals; Benzodiazepines; GABAergic Neurons; Humans; Melatonin; Sleep Initiation and Maintenance Dis | 2016 |
Circadian typology: a comprehensive review.
Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di | 2012 |
Sports chronobiology consultation: from the lab to the arena.
Topics: Altitude; Biological Clocks; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian R | 2005 |
3 trials available for melatonin and Chemical Dependence
| Article | Year |
|---|---|
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara | 2011 |
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara | 2011 |
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara | 2011 |
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara | 2011 |
Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Circad | 2007 |
Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; F | 1999 |
6 other studies available for melatonin and Chemical Dependence
| Article | Year |
|---|---|
Sedative drug-use in Denmark, 2000 to 2019: a nationwide drug utilization study.
Topics: Benzodiazepines; Denmark; Drug Prescriptions; Drug Utilization; Female; Humans; Hypnotics and Sedati | 2023 |
Circadian phase in sleep-disturbed adolescents with a history of substance abuse: a pilot study.
Topics: Adolescent; Documentation; Female; Humans; Male; Melatonin; Personality Inventory; Pilot Projects; P | 2008 |
Preclinical evaluation of the reinforcing and discriminative stimulus effects of agomelatine (S-20098), a melatonin agonist.
Topics: Acetamides; Animals; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationshi | 1998 |
Melatonin therapy: from benzodiazepine-dependent insomnia to authenticity and autonomy.
Topics: Anti-Anxiety Agents; Benzodiazepines; Freedom; Humans; Melatonin; Memory; Sleep; Sleep Initiation an | 1999 |
Hypothalamic involvement in chronic migraine.
Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Chronobiology Disorders; Circadian Rhythm; Co | 2001 |
[Circadian neuroendocrinologic profile in patients with multiple drug abuse].
Topics: Adult; Alcoholism; Circadian Rhythm; Female; Gonadotropins, Pituitary; Hormones; Humans; Hydrocortis | 1986 |