melatonin has been researched along with Cerebral Infarction in 16 studies
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 9.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "To investigate the mechanism of electroacupuncture in alleviating cerebral ischemia injury in cerebral ischemia-reperfusion rats by regulating melatonin - NOD-like receptor protein 3 (NLRP3) mediated pyroptosis." | 8.31 | [Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis]. ( Chen, B; Liang, H; Liu, JJ; Luo, J; Ruan, S; Wang, F; Wang, YX; Yan, NW; Zhong, XY, 2023) |
| " Melatonin is neuroprotective against cerebral ischemia-reperfusion injury (CIRI) in non-DM, normoglycemic animals through anti-oxidant effect, anti-inflammation, and anti-apoptosis." | 8.31 | Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects. ( Cheung, RTF; Xu, Q, 2023) |
| " In this study, the neuroprotective effects of melatonin (Mel) on a rat model of cerebral ischemia/reperfusion injury (CIRI) were assessed by multi-parametric MRI combined with histopathological techniques for longitudinal monitoring of the lesion microenvironment." | 8.31 | Multi-parametric MRI assessment of melatonin regulating the polarization of microglia in rats after cerebral ischemia/reperfusion injury. ( An, L; Bi, F; Gong, P; Li, C; Li, Z; Song, X; Wang, X; Xiao, P; Yu, M; Zhang, M, 2023) |
| "Melatonin treatment significantly decreased infarct volume and cerebral apoptosis; mitigated endoplasmic reticulum stress and mitochondrial dysfunction; and inhibited CI/R injury-induced oxidative/nitrative stress and nuclear factor-κB activation, which was eradicated in RORα-deficient mice." | 5.56 | The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin. ( Ai, L; Gao, L; Gao, Y; Petersen, L; Pu, J; Qin, Z; Tong, R; Yan, Y; Zang, M; Zhao, Y; Zhong, F; Zhu, C, 2020) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 5.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 5.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "To investigate the mechanism of electroacupuncture in alleviating cerebral ischemia injury in cerebral ischemia-reperfusion rats by regulating melatonin - NOD-like receptor protein 3 (NLRP3) mediated pyroptosis." | 4.31 | [Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis]. ( Chen, B; Liang, H; Liu, JJ; Luo, J; Ruan, S; Wang, F; Wang, YX; Yan, NW; Zhong, XY, 2023) |
| " Melatonin is neuroprotective against cerebral ischemia-reperfusion injury (CIRI) in non-DM, normoglycemic animals through anti-oxidant effect, anti-inflammation, and anti-apoptosis." | 4.31 | Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects. ( Cheung, RTF; Xu, Q, 2023) |
| " In this study, the neuroprotective effects of melatonin (Mel) on a rat model of cerebral ischemia/reperfusion injury (CIRI) were assessed by multi-parametric MRI combined with histopathological techniques for longitudinal monitoring of the lesion microenvironment." | 4.31 | Multi-parametric MRI assessment of melatonin regulating the polarization of microglia in rats after cerebral ischemia/reperfusion injury. ( An, L; Bi, F; Gong, P; Li, C; Li, Z; Song, X; Wang, X; Xiao, P; Yu, M; Zhang, M, 2023) |
| "Melatonin treatment significantly decreased infarct volume and cerebral apoptosis; mitigated endoplasmic reticulum stress and mitochondrial dysfunction; and inhibited CI/R injury-induced oxidative/nitrative stress and nuclear factor-κB activation, which was eradicated in RORα-deficient mice." | 1.56 | The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin. ( Ai, L; Gao, L; Gao, Y; Petersen, L; Pu, J; Qin, Z; Tong, R; Yan, Y; Zang, M; Zhao, Y; Zhong, F; Zhu, C, 2020) |
| "Melatonin treatment improved the penumbral CBF in the wild-type mice." | 1.33 | Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. ( Cheung, RT; Huang, L; Li, G; Liu, S; Zou, LY, 2006) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 1.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, D | 1 |
| Liu, Y | 1 |
| Huang, H | 1 |
| Hu, M | 1 |
| Li, T | 1 |
| Wang, S | 1 |
| Shen, S | 1 |
| Wu, R | 1 |
| Cai, W | 1 |
| Lu, T | 1 |
| Lu, Z | 1 |
| Yan, NW | 1 |
| Ruan, S | 1 |
| Wang, F | 1 |
| Wang, YX | 1 |
| Chen, B | 1 |
| Luo, J | 1 |
| Liu, JJ | 1 |
| Liang, H | 1 |
| Zhong, XY | 1 |
| Xu, Q | 1 |
| Cheung, RTF | 1 |
| Li, Z | 1 |
| Gong, P | 1 |
| Zhang, M | 1 |
| Li, C | 1 |
| Xiao, P | 1 |
| Yu, M | 1 |
| Wang, X | 2 |
| An, L | 1 |
| Bi, F | 1 |
| Song, X | 1 |
| Zang, M | 1 |
| Zhao, Y | 1 |
| Gao, L | 1 |
| Zhong, F | 1 |
| Qin, Z | 1 |
| Tong, R | 1 |
| Ai, L | 1 |
| Petersen, L | 1 |
| Yan, Y | 1 |
| Gao, Y | 1 |
| Zhu, C | 1 |
| Pu, J | 1 |
| Yan, C | 1 |
| Zhang, B | 1 |
| Koh, PO | 1 |
| Cam, E | 1 |
| Yulug, B | 1 |
| Cengiz, N | 1 |
| Poelkin, E | 1 |
| Isýk, D | 1 |
| Bakar, M | 1 |
| Ozan, E | 1 |
| Kilic, E | 3 |
| Ulas, UH | 1 |
| Korkmaz, A | 1 |
| Karadas, O | 1 |
| Odabasi, Z | 1 |
| Reiter, RJ | 2 |
| Sunami, E | 1 |
| Usuda, K | 1 |
| Nishiyama, Y | 1 |
| Otori, T | 1 |
| Katsura, K | 1 |
| Katayama, Y | 1 |
| Kilic, U | 1 |
| Yilmaz, B | 1 |
| Yüksel, A | 1 |
| Pei, Z | 2 |
| Pang, SF | 1 |
| Cheung, RT | 3 |
| Zou, LY | 1 |
| Liu, S | 1 |
| Li, G | 1 |
| Huang, L | 1 |
| Ozdemir, YG | 1 |
| Bolay, H | 1 |
| Keleştimur, H | 1 |
| Dalkara, T | 1 |
| Borlongan, CV | 1 |
| Yamamoto, M | 1 |
| Takei, N | 1 |
| Kumazaki, M | 1 |
| Ungsuparkorn, C | 1 |
| Hida, H | 1 |
| Sanberg, PR | 1 |
| Nishino, H | 1 |
| Ho, HT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Memantine for Enhanced Stroke Recovery[NCT02144584] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2014-01-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for melatonin and Cerebral Infarction
| Article | Year |
|---|---|
A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Cerebral Infarction; Depression; | 2012 |
15 other studies available for melatonin and Cerebral Infarction
| Article | Year |
|---|---|
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Endothelial Cells; Ischemic Stroke; Melatonin; | 2023 |
[Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis].
Topics: Animals; Brain Injuries; Brain Ischemia; Caspase 1; Cerebral Infarction; Electroacupuncture; Melaton | 2023 |
Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Type 1; Hyperglycemia; Infarction, | 2023 |
Multi-parametric MRI assessment of melatonin regulating the polarization of microglia in rats after cerebral ischemia/reperfusion injury.
Topics: Amides; Animals; Brain Ischemia; Cerebral Infarction; Magnetic Resonance Imaging; Melatonin; Microgl | 2023 |
The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Cerebral Infarction; Circadian Rhythm; Disease Mod | 2020 |
Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants.
Topics: Brain; Brain Injuries; Case-Control Studies; Cerebral Infarction; Cerebral Intraventricular Hemorrha | 2019 |
Melatonin attenuates the cerebral ischemic injury via the MEK/ERK/p90RSK/bad signaling cascade.
Topics: Animals; bcl-Associated Death Protein; Brain Injuries; Brain Ischemia; Cell Death; Cerebral Infarcti | 2008 |
Melatonin: a suitable agent for depression associated with stroke?
Topics: Animals; Antioxidants; Cerebral Infarction; Depressive Disorder; Humans; Ischemic Attack, Transient; | 2008 |
Sunrise-related headache: case report.
Topics: Adult; Cerebral Infarction; Circadian Rhythm; Cysts; Headache Disorders; Humans; Hypothalamus; Magne | 2010 |
Effects of memantine and melatonin on signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia in mice.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cerebral Infarction; Corpus Striatum; Disease Models | 2013 |
Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice.
Topics: Animals; Brain; Brain Edema; Cerebral Infarction; Cerebrovascular Circulation; Cyclooxygenase 1; Dis | 2006 |
Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia.
Topics: Animals; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationshi | 1999 |
Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Cell Survival; Cerebral Infarction; Free Radical Scavengers; Gl | 2000 |
Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat.
Topics: Animals; Blood Pressure; Brain; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Rela | 2002 |