melatonin has been researched along with Cephalgia Syndromes in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is increasing evidence that headache disorders are connected with melatonin secretion and pineal function." | 8.83 | Potential therapeutic use of melatonin in migraine and other headache disorders. ( Cavalheiro, EA; Masruha, MR; Moreira-Filho, CA; Peres, MF; Zukerman, E, 2006) |
| "Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment." | 6.43 | Melatonin, the pineal gland and their implications for headache disorders. ( Peres, MF, 2005) |
| "Melatonin intervention has no significant influence on well-being, sleepiness, sleep quality, pain intensity after 1 and 3 hours, headache, depression, and dizziness for laparoscopic cholecystectomy." | 5.01 | The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. ( Wang, Y; Xu, H; Yang, J; Zhang, J, 2019) |
| "There is increasing evidence that headache disorders are connected with melatonin secretion and pineal function." | 4.83 | Potential therapeutic use of melatonin in migraine and other headache disorders. ( Cavalheiro, EA; Masruha, MR; Moreira-Filho, CA; Peres, MF; Zukerman, E, 2006) |
| "Models of sleep physiology and insomnia are discussed, along with the potential implications for the chronification of migraine and tension-type headache." | 2.48 | Chronic headaches and insomnia: working toward a biobehavioral model. ( Ong, JC; Park, M, 2012) |
| "Melatonin is believed to be a significant element in migraine and in other headache disorders, which has implications for treatment." | 2.46 | Headache endocrinological aspects. ( Prieto Peres, MF; Valença, MM, 2010) |
| "Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment." | 2.43 | Melatonin, the pineal gland and their implications for headache disorders. ( Peres, MF, 2005) |
| "Several theories attempt to explain migraine etiology." | 2.41 | The therapeutic potential of melatonin in migraines and other headache types. ( Gagnier, JJ, 2001) |
| "Frequent and recurrent migraine headaches can, over time, pose the additional risks of stroke, brain damage, heart failure and attention deficit." | 1.33 | A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients. ( Eli, R; Fasciano, JA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Wang, Y | 1 |
| Xu, H | 1 |
| Yang, J | 1 |
| Rozen, TD | 2 |
| Beams, JL | 1 |
| Ulas, UH | 1 |
| Korkmaz, A | 1 |
| Karadas, O | 1 |
| Odabasi, Z | 1 |
| Reiter, RJ | 1 |
| Prieto Peres, MF | 1 |
| Valença, MM | 1 |
| Ong, JC | 1 |
| Park, M | 1 |
| Peres, MF | 3 |
| Eli, R | 1 |
| Fasciano, JA | 1 |
| Masruha, MR | 1 |
| Zukerman, E | 1 |
| Moreira-Filho, CA | 1 |
| Cavalheiro, EA | 1 |
| Stiles, MA | 1 |
| Oshinsky, M | 1 |
| Gagnier, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches[NCT00391755] | Phase 4 | 4 participants (Actual) | Interventional | 2006-10-31 | Terminated (stopped due to Failure to recruit necessary number of patients.) | ||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
6 reviews available for melatonin and Cephalgia Syndromes
| Article | Year |
|---|---|
The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
Topics: Central Nervous System Depressants; Cholecystectomy, Laparoscopic; Depression; Dizziness; Headache D | 2019 |
Headache endocrinological aspects.
Topics: Animals; Circadian Rhythm; Headache; Headache Disorders; Headache Disorders, Primary; Humans; Melato | 2010 |
Chronic headaches and insomnia: working toward a biobehavioral model.
Topics: Actigraphy; Adaptation, Psychological; Caffeine; Chronobiology Phenomena; Comorbidity; Headache Diso | 2012 |
Melatonin, the pineal gland and their implications for headache disorders.
Topics: Circadian Rhythm; Headache Disorders; Humans; Melatonin; Pineal Gland; Randomized Controlled Trials | 2005 |
Potential therapeutic use of melatonin in migraine and other headache disorders.
Topics: Animals; Headache Disorders; Humans; Melatonin; Migraine Disorders | 2006 |
The therapeutic potential of melatonin in migraines and other headache types.
Topics: Female; Headache Disorders; Humans; Male; Melatonin; Migraine Disorders; Pineal Gland | 2001 |
4 other studies available for melatonin and Cephalgia Syndromes
| Article | Year |
|---|---|
A case of post-traumatic LASH syndrome responsive to indomethacin and melatonin (a man with a unique triad of indomethacin-responsive trigeminal autonomic cephalalgias).
Topics: Accidents, Traffic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressan | 2015 |
Sunrise-related headache: case report.
Topics: Adult; Cerebral Infarction; Circadian Rhythm; Cysts; Headache Disorders; Humans; Hypothalamus; Magne | 2010 |
A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients.
Topics: Antioxidants; Headache Disorders; Humans; Hydrocortisone; Melatonin; Migraine Disorders; Moclobemide | 2006 |
Remitting form of hemicrania continua with seasonal pattern.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Headache Disorders; Humans; Indomethacin; Melatonin | 2001 |