melatonin has been researched along with Cell Transformation, Neoplastic in 34 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evidence suggests that genomic instability is responsible for cancer incidence after exposure to carcinogenic agents, and increases the risk of secondary cancers following treatment with radiotherapy or chemotherapy." | 2.61 | Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment. ( Farhood, B; Goradel, NH; Khanlarkhani, N; Mortezaee, K; Najafi, M; Sahebkar, A, 2019) |
| "Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of the circadian rhythm." | 2.58 | Melatonin and Cancer Hallmarks. ( Talib, WH, 2018) |
| "While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer, this is changing quickly with many cancer types having been shown to be susceptible to inhibition by melatonin." | 2.55 | Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. ( Acuna-Castroviejo, D; Qin, L; Reiter, RJ; Rosales-Corral, SA; Tan, DX; Xu, K; Yang, SF, 2017) |
| "Melatonin has revealed itself to be a pleiotropic and multitasking molecule." | 2.48 | Role of melatonin in cancer treatment. ( Arias-Santiago, S; Cutando, A; DE Diego, RG; DE Vicente, J; López-Valverde, A, 2012) |
| "Of particular relevance to breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol." | 2.45 | Circulating melatonin and the risk of breast and endometrial cancer in women. ( Schernhammer, ES; Viswanathan, AN, 2009) |
| "Some human and murine in vitro cancer cell lines are inhibited by physiological concentrations of melatonin, but the majority of the tested cell lines is resistant to melatonin or can be inhibited at pharmacological doses only." | 2.40 | [Significance of melatonin in malignant diseases]. ( Bartsch, C; Bartsch, H, 1997) |
| "Melatonin is a well-known natural hormone, which shows a potential anticancer effect in many human cancers." | 1.91 | Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis. ( Deng, Z; Fang, Y; Ju, L; Liu, W; Qian, K; Shan, D; Shen, D; Wang, G; Wang, X; Xiao, Y; Yu, M; Zhang, Y; Zhou, F, 2023) |
| "Melatonin has been known to be a chemopreventive agent since its levels inversely correlate with the risk of developing cancer." | 1.39 | Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation. ( Blandino, G; Cambria, MA; Grasso, G; Marani, M; Mori, F; Muti, P; Santoro, R; Strano, S, 2013) |
| "Treatment with melatonin prevented premature aging and tumorigenesis in rodents." | 1.38 | Light-at-night-induced circadian disruption, cancer and aging. ( Anisimov, VN; Panchenko, AV; Popovich, IG; Vinogradova, IA; Zabezhinski, MA, 2012) |
| "Melatonin treatment supressed MDA and catalase levels in blood serum but not in tumor tissue." | 1.34 | [Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice]. ( Anisimov, VN; Plotnikova, NA; Vesnushkin, GM, 2007) |
| "Melatonin or epitalon treatment was followed by longer mean and maximum survival in the 10% of the last survivors among SAMP-1." | 1.33 | [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)]. ( Anisimov, VN; Iashin, AI; Khavinson, VKh; Popovich, IG; Rozenfel'd, SV; Semenchenko, AV; Zabezhinskiĭ, MA, 2005) |
| "Isoproterenol (10(-6) M) was applied for 20 min after 2." | 1.32 | Long term inhibition by estradiol or progesterone of melatonin secretion after administration of a mammary carcinogen, the dimethyl benz(a)anthracene, in Sprague-Dawley female rat; inhibitory effect of Melatonin on mammary carcinogenesis. ( De Jonage-Canonico, MB; Kerdelhué, B; Lenoir, V; Martin, A; Scholler, R, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 13 (38.24) | 29.6817 |
| 2010's | 12 (35.29) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, D | 1 |
| Deng, Z | 1 |
| Liu, W | 1 |
| Zhou, F | 1 |
| Fang, Y | 1 |
| Shan, D | 1 |
| Wang, G | 1 |
| Qian, K | 1 |
| Yu, M | 1 |
| Zhang, Y | 1 |
| Ju, L | 1 |
| Xiao, Y | 1 |
| Wang, X | 1 |
| Reiter, RJ | 2 |
| Rosales-Corral, SA | 1 |
| Tan, DX | 1 |
| Acuna-Castroviejo, D | 1 |
| Qin, L | 1 |
| Yang, SF | 1 |
| Xu, K | 1 |
| Talib, WH | 1 |
| Farhood, B | 1 |
| Goradel, NH | 1 |
| Mortezaee, K | 1 |
| Khanlarkhani, N | 1 |
| Najafi, M | 1 |
| Sahebkar, A | 1 |
| Mirza-Aghazadeh-Attari, M | 1 |
| Mohammadzadeh, A | 1 |
| Adib, A | 1 |
| Darband, SG | 1 |
| Sadighparvar, S | 1 |
| Mihanfar, A | 1 |
| Majidinia, M | 1 |
| Yousefi, B | 1 |
| Sanchez-Barcelo, EJ | 1 |
| Mediavilla, MD | 1 |
| Vriend, J | 1 |
| Gaikwad, NW | 1 |
| Yang, L | 1 |
| Rogan, EG | 1 |
| Cavalieri, EL | 1 |
| Viswanathan, AN | 1 |
| Schernhammer, ES | 1 |
| Blask, DE | 3 |
| Siegfried, JM | 1 |
| Iamshanov, VA | 1 |
| Gamaleĭ, IA | 1 |
| Kirpichnikova, KM | 1 |
| Filatova, NA | 1 |
| Man'cheva, TA | 1 |
| Demidov, DV | 1 |
| Plotnikova, NA | 2 |
| Kharitonova, TV | 1 |
| Pashkevich, IV | 1 |
| Anisimov, VN | 5 |
| Cutando, A | 1 |
| López-Valverde, A | 1 |
| Arias-Santiago, S | 1 |
| DE Vicente, J | 1 |
| DE Diego, RG | 1 |
| Vinogradova, IA | 1 |
| Panchenko, AV | 1 |
| Popovich, IG | 3 |
| Zabezhinski, MA | 1 |
| Santoro, R | 1 |
| Mori, F | 1 |
| Marani, M | 1 |
| Grasso, G | 1 |
| Cambria, MA | 1 |
| Blandino, G | 1 |
| Muti, P | 1 |
| Strano, S | 1 |
| Dauchy, RT | 1 |
| Sauer, LA | 1 |
| Krause, JA | 1 |
| Brainard, GC | 1 |
| De Jonage-Canonico, MB | 2 |
| Lenoir, V | 2 |
| Martin, A | 2 |
| Scholler, R | 2 |
| Kerdelhué, B | 2 |
| Zabezhinskiĭ, MA | 1 |
| Rozenfel'd, SV | 1 |
| Khavinson, VKh | 1 |
| Semenchenko, AV | 1 |
| Iashin, AI | 1 |
| Perrin, MH | 1 |
| Sahar, S | 1 |
| Sassone-Corsi, P | 1 |
| Vesnushkin, GM | 1 |
| Subramanian, P | 1 |
| Mirunalini, S | 1 |
| Dakshayani, KB | 1 |
| Pandi-Perumal, SR | 1 |
| Trakht, I | 1 |
| Cardinali, DP | 1 |
| Mhatre, MC | 1 |
| Shah, PN | 1 |
| Juneja, HS | 1 |
| Bartsch, C | 1 |
| Bartsch, H | 1 |
| Jones, MP | 1 |
| Melan, MA | 1 |
| Witt-Enderby, PA | 1 |
| Cieśla, W | 1 |
| Gurney, JG | 1 |
| van Wijngaarden, E | 1 |
| Buswell, RS | 1 |
| Conti, A | 1 |
| Haran-Ghera, N | 1 |
| Maestroni, GJ | 1 |
| Hill, SM | 1 |
| Orstead, KM | 1 |
| Massa, JS | 1 |
| Ebels, I | 1 |
| Balemans, MG | 1 |
14 reviews available for melatonin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, | 2017 |
Melatonin and Cancer Hallmarks.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Disease Pr | 2018 |
Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Cell Transformation, Neoplast | 2019 |
Melatonin-mediated regulation of autophagy: Making sense of double-edged sword in cancer.
Topics: Animals; Autophagy; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Melatonin; Neoplasms; S | 2019 |
Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Cell Transformation, Neoplastic; COP9 Signalosome Comple | 2016 |
Circulating melatonin and the risk of breast and endometrial cancer in women.
Topics: Aromatase; Breast Neoplasms; Carcinoma; Case-Control Studies; Cell Transformation, Neoplastic; Circa | 2009 |
Melatonin, sleep disturbance and cancer risk.
Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Circadian Rhythm; Dietary Fats; Female; | 2009 |
Role of melatonin in cancer treatment.
Topics: Age Factors; Cell Transformation, Neoplastic; Clinical Trials as Topic; Humans; Melatonin; Neoplasms | 2012 |
[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].
Topics: Aging, Premature; Animals; Biomarkers; Carbon; Cell Transformation, Neoplastic; Melatonin; Mice; Neo | 2004 |
Circadian clock and breast cancer: a molecular link.
Topics: Acetylation; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Bre | 2007 |
[Epiphysis (pineal gland) and tumorous growth].
Topics: Adjuvants, Immunologic; Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Cell Transformatio | 1980 |
[Significance of melatonin in malignant diseases].
Topics: Animals; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Humans; Melatonin; Neopl | 1997 |
Extremely low frequency electromagnetic fields (EMF) and brain cancer in adults and children: review and comment.
Topics: Adult; Brain Neoplasms; Calcium; Cell Transformation, Neoplastic; Child; Cluster Analysis; Cocarcino | 1999 |
Physiological aspects of pineal functions in mammals.
Topics: Acetylserotonin O-Methyltransferase; Animals; Biopterins; Cell Transformation, Neoplastic; Female; g | 1986 |
20 other studies available for melatonin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; DNA-Binding Proteins; Glycolysis; Humans; Melato | 2023 |
Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones.
Topics: Absorption; Cell Transformation, Neoplastic; Estradiol; Estrogens; Humans; Melatonin; Models, Chemic | 2009 |
Early changes in pulmonary gene expression following tobacco exposure shed light on the role of estrogen metabolism in lung carcinogenesis.
Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Cell Transformation, Neoplastic; Ci | 2010 |
[Role of polymeric nitric oxide in oncopathology].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Electromagnetic Fields; Humans; Melatonin; Ne | 2010 |
[Effect of melatonin on the functional properties of transformed cells].
Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neopla | 2011 |
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Transformation, Neoplastic; Female; Lipid Peroxidation; | 2011 |
Light-at-night-induced circadian disruption, cancer and aging.
Topics: Age Factors; Aging; Animals; Anticarcinogenic Agents; Blindness; Cell Transformation, Neoplastic; Ci | 2012 |
Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA Damage; HCT116 C | 2013 |
Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression.
Topics: Animals; Antioxidants; Antithrombins; Breast Neoplasms; Cell Transformation, Neoplastic; Circadian R | 2003 |
Long term inhibition by estradiol or progesterone of melatonin secretion after administration of a mammary carcinogen, the dimethyl benz(a)anthracene, in Sprague-Dawley female rat; inhibitory effect of Melatonin on mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenergic beta-Agonists; Animals; Antioxidants; Carcinogens; Carc | 2003 |
[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
Topics: Aging; Animals; Cell Transformation, Neoplastic; Female; Life Expectancy; Melatonin; Mice; Oligopept | 2005 |
Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague-Dawley rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Antioxidants; Carcinogens; Cell Transform | 2005 |
[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice].
Topics: Animals; Antioxidants; Benzo(a)pyrene; Catalase; Cell Transformation, Neoplastic; Female; Malondiald | 2007 |
Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Transfor | 2007 |
Effect of varying photoperiods on mammary morphology, DNA synthesis, and hormone profile in female rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromocriptine; Cell Transformation, Neoplastic; Darkness; | 1984 |
Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Count; Cell Division; Cell Transformation, Neoplastic; Colfo | 2000 |
Can melatonin regulate the expression of prohormone convertase 1 and 2 genes via monomeric and dimeric forms of RZR/ROR nuclear receptor, and can melatonin influence the processes of embryogenesis or carcinogenesis by disturbing the proportion of cAMP and
Topics: Apoptosis; Aspartic Acid Endopeptidases; Cell Transformation, Neoplastic; Cyclic AMP; Cyclic GMP; Di | 2001 |
Letter: The pineal and neoplasia.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Leukemia, Experimental; Melatonin; Mice; Mice, | 1975 |
Role of pineal melatonin and melatonin-induced-immuno-opioids in murine leukemogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Female; Leukemia, Experimental; Melatonin; Mice; Mice, Inb | 1992 |
Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7,12-dimethylbenzanthracene-(DMBA)-induced mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cell Transformation, Neoplastic; Female; Foo | 1986 |